Longpo Geng, Mingming Zhu, Dongjun Luo, Huihui Chen, Binghua Li, Yuanxiang Lao, Hongda An, Yue Wu, Yunzheng Li, Anliang Xia, Yi Shi, Zhuting Tong, Shanshan Lu, Dengqiu Xu, Xu Wang, Wenjun Zhang, Beicheng Sun, Zhu Xu
Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents as the second leading cause of cancer-related mortality. DNA damage-based radiotherapy (RT) plays a pivotal role in the treatment of HCC. Nevertheless, radioresistance remains a primary factor contributing to the failure of radiation therapy in HCC patients. In this study, we investigated the functional role of transketolase (TKT) in the repair of DNA double-strand breaks (DSBs) in HCC. Our research unveiled that TKT is involved in DSB repair, and its depletion significantly reduces both non-homologous end joining (NHEJ) and homologous recombination (HR)-mediated DSB repair...
January 12, 2024: Oncogene