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https://www.readbyqxmd.com/read/29339942/a-new-hat-for-librarians-providing-redcap-support-to-establish-the-library-as-a-central-data-hub
#1
Kevin Read, Fred Willie Zametkin LaPolla
Background: REDCap, an electronic data capture tool, supports good research data management, but many researchers lack familiarity with the tool. While a REDCap administrator provided technical support and a clinical data management support unit provided study design support, a service gap existed. Case Presentation: Librarians with REDCap expertise sought to increase and improve usage through outreach, workshops, and consultations. In collaboration with a REDCap administrator and the director of the clinical data management support unit, the role of the library was established in providing REDCap training and consultations...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29339936/satellite-stories-capturing-professional-experiences-of-academic-health-sciences-librarians-working-in-delocalized-health-sciences-programs
#2
Jackie Phinney, Amanda Rose Horsman
Objective: Health sciences training programs have progressively expanded onto satellite campuses, allowing students the opportunity to learn in communities away from an academic institution's main campus. This expansion has encouraged a new role for librarians to assume, in that a subset of health sciences librarians identify as "satellite librarians" who are permanently located at a distance from the main campus. Due to the unique nature of this role and lack of existing data on the topic, the authors investigated the experiences and perceptions of this unique group of information professionals...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29339135/quantitative-monitoring-the-anti-solvent-crystallization-and-storage-process-for-nandrolone-by-near-infrared-spectroscopy
#3
Xia Zeng, Xinnuo Xiong, Hongqin Yang, Bin Tang, Qiaohong Du, Quan Hou, Zili Suo, Hui Li
A novel hydrate (SH2O) of nandrolone (NT) was prepared by anti-solvent methods. The crystallization processes with two schemes (A and B) were monitored by in-line near-infrared (NIR) spectroscopy. The amounts of SH2O in powder samples obtained by the anti-solvent crystallization and storage process were quantified by NIR combined with chemometrics methods. In-line NIR spectra from 4500 to 8000 cm-1 were chosen to capture physicochemical changes during the whole crystallization process. The combination of the principal component (PCA) results with offline characterization (scanning electron microscopy, powder x-ray diffraction, NIR) data showed that both schemes yielded high purity SH2O products, but the crystallization speed of Scheme B was significantly accelerated...
January 12, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29336549/top-down-hydrogen-deuterium-exchange-analysis-of-protein-structures-using-ultraviolet-photodissociation-uvpd
#4
Nicholas I Brodie, Romain Huguet, Terry Zhang, Rosa Viner, Vlad Zabrouskov, Jingxi Pan, Evgeniy V Petrotchenko, Christoph H Borchers
Top-down hydrogen-deuterium exchange (HDX) analysis using electron capture or transfer dissociation Fourier transform mass spectrometry is a powerful method for the analysis of secondary structure of proteins in solution. The resolution of the method is a function of the extensive fragmentation of backbone bonds in the proteins. While fragmentation is usually extensive near the N- and C-termini, electron capture (ECD) or electron transfer dissociation (ETD) fragmentation methods sometimes lack good coverage of certain regions of the protein - most often in the middle of the sequence...
January 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29335236/tanzania-health-information-technology-t-hit-system-pilot-test-of-a-tablet-based-system-to-improve-prevention-of-mother-to-child-transmission-of-hiv
#5
Sheana Bull, Deborah Sk Thomas, Elias C Nyanza, Sospatro E Ngallaba
BACKGROUND: The prevention of mother-to-child transmission (PMTCT) of HIV requires innovative solutions. Although routine monitoring is effective in some areas, standardized and easy-to-scale solutions to identify and monitor pregnant women, test them for HIV, and treat them and their children is still lacking. Mobile health (mHealth) offers opportunities for surveillance and reporting in rural areas of low- and middle-income countries. OBJECTIVE: The aim of this study was to document the preliminary impacts of the Tanzania Health Information Technology (T-HIT) system mHealth intervention aimed at health workers for PMTCT care delivery and capacity building in a rural area of Tanzania...
January 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29334983/an-individually-tailored-family-centered-intervention-for-pediatric-obesity-in-primary-care-study-protocol-of-a-randomized-type-ii-hybrid-effectiveness-implementation-trial-raising-healthy-children-study
#6
Justin D Smith, Cady Berkel, Neil Jordan, David C Atkins, Shrikanth S Narayanan, Carlos Gallo, Kevin J Grimm, Thomas J Dishion, Anne M Mauricio, Jenna Rudo-Stern, Mariah K Meachum, Emily Winslow, Meg M Bruening
BACKGROUND: Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the possibility of developing cardiometabolic risk factors. Family-based behavioral interventions are an underutilized, evidence-based approach that have been found to significantly prevent excess weight gain and obesity in children and adolescents. Poor program availability, low participation rates, and non-adherence are noted barriers to positive outcomes...
January 15, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29334912/estimating-the-total-prevalence-and-incidence-of-end-stage-kidney-disease-among-aboriginal-and-non-aboriginal-populations-in-the-northern-territory-of-australia-using-multiple-data-sources
#7
Lin Li, Steven Guthridge, Shu Qin Li, Yuejen Zhao, Paul Lawton, Alan Cass
BACKGROUND: Most estimates for End Stage Kidney Disease (ESKD) prevalence and incidence are based on renal replacement therapy (RRT) registers. However, not all people with ESKD will commence RRT and estimates based only on RRT registry data will underestimate the true burden of ESKD in the community. This study estimates the total number of Northern Territory (NT) residents with ESKD including: those receiving RRT, those diagnosed but not receiving RRT and an estimate of "undiagnosed" cases...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29331425/low-picomolar-label-free-procalcitonin-analytical-detection-with-an-electrolyte-gated-organic-field-effect-transistor-based-electronic-immunosensor
#8
Preethi Seshadri, Kyriaki Manoli, Nicole Schneiderhan-Marra, Uwe Anthes, Piotr Wierzchowiec, Klaus Bonrad, Cinzia Di Franco, Luisa Torsi
Herein a label-free immunosensor based on electrolyte-gated organic field-effect transistor (EGOFET) was developed for the detection of procalcitonin (PCT), a sepsis marker. Antibodies specific to PCT were immobilized on the poly-3-hexylthiophene (P3HT) organic semiconductor surface through direct physical adsorption followed by a post-treatment with bovine serum albumin (BSA) which served as the blocking agent to prevent non-specific adsorption. Antibodies together with BSA (forming the whole biorecognition layer) served to selectively capture the procalcitonin target analyte...
December 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29326334/clinical-and-inflammatory-phenotyping-by-breathomics-in-chronic-airway-diseases-irrespective-of-the-diagnostic-label
#9
Rianne de Vries, Yennece W F Dagelet, Pien Spoor, Erik Snoey, Patrick M C Jak, Paul Brinkman, Erica Dijkers, Simon K Bootsma, Fred Elskamp, Frans H C de Jongh, Eric G Haarman, Johannes C C M In 't Veen, Anke-Hilse Maitland-van der Zee, Peter J Sterk
Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set.This was a multicentre cross-sectional study in which exhaled breath from asthma and COPD patients (n=435; training n=321 and validation n=114) was analysed using eNose technology...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29304390/the-cutting-edge-micro-ct-for-quantitative-toolmark-analysis-of-sharp-force-trauma-to-bone
#10
D G Norman, D G Watson, B Burnett, P M Fenne, M A Williams
Toolmark analysis involves examining marks created on an object to identify the likely tool responsible for creating those marks (e.g., a knife). Although a potentially powerful forensic tool, knife mark analysis is still in its infancy and the validation of imaging techniques as well as quantitative approaches is ongoing. This study builds on previous work by simulating real-world stabbings experimentally and statistically exploring quantitative toolmark properties, such as cut mark angle captured by micro-CT imaging, to predict the knife responsible...
December 30, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29303256/high-precision-measurement-of-n2o-concentration-in-ice-cores
#11
Yeongjun Ryu, Jinho Ahn, Ji-Woong Yang
Atmospheric nitrous oxide (N2O) is a greenhouse gas and ozone-depleting substance whose emissions are substantially perturbed by current human activities. Although air trapped in polar ice cores can provide direct information about N2O evolution, analytical precision was not previously sufficient for high temporal resolution studies. In this work, we present a highly improved analytical technique with which to study N2O concentrations in ancient-air-trapped ice cores. We adopt a melt-refreezing method to extract air and use a gas chromatography-electron capture detector (GC-ECD) to determine N2O concentrations...
January 5, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29291418/interrater-reliability-in-interpretation-of-neuropathic-pediatric-urodynamic-tracings-an-expanded-multi-center-study
#12
Anne G Dudley, Mark C Adams, John W Brock, Douglass B Clayton, David B Joseph, Chester J Koh, Paul A Merguerian, John C Pope, Jonathan C Routh, John C Thomas, Duong D Tu, M Chad Wallis, John S Wiener, Elizabeth B Yerkes, Chelsea J Lauderdale, Chevis N Shannon, Stacy T Tanaka
INTRODUCTION: and Objectives: Urodynamics often guide treatment of neuropathic bladder and are reported as objective data points in multi-institutional trials. Urodynamic interpretation, however, can be variable. In a pilot study, pediatric urologists interpreting videourodynamics (VUDS) showed only moderate agreement despite similar training and practice patterns. We hypothesized the pilot study variability would be replicated in a multi-institutional study. METHODS: We developed an anonymous electronic survey that contained twenty scenarios, each with a brief patient history, one urodynamic tracing and fluoroscopic image...
December 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29289189/an-ultrafast-programmable-electrical-tester-for-enabling-time-resolved-sub-nanosecond-switching-dynamics-and-programming-of-nanoscale-memory-devices
#13
Krishna Dayal Shukla, Nishant Saxena, Anbarasu Manivannan
Recent advancements in commercialization of high-speed non-volatile electronic memories including phase change memory (PCM) have shown potential not only for advanced data storage but also for novel computing concepts. However, an in-depth understanding on ultrafast electrical switching dynamics is a key challenge for defining the ultimate speed of nanoscale memory devices that demands for an unconventional electrical setup, specifically capable of handling extremely fast electrical pulses. In the present work, an ultrafast programmable electrical tester (PET) setup has been developed exceptionally for unravelling time-resolved electrical switching dynamics and programming characteristics of nanoscale memory devices at the picosecond (ps) time scale...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29288521/indigenous-cultural-competence-a-dental-faculty-curriculum-review
#14
C Forsyth, M Irving, M Tennant, S Short, J Gilroy
BACKGROUND: Indigenous Australians have more than double the rate of poor oral health than their non-Indigenous counterparts. Cultural competence of dental and oral health practitioners is fundamental to health care and quality of life in addressing health disparities in minority cultural groups in Australia. Higher education curricula reviews have identified the need for institutions to incorporate Indigenous culture and knowledge more widely into the curricula to improve educational outcomes for Indigenous Australians and to increase cultural competence for all students...
December 30, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29283893/out-of-system-care-and-recording-of-patient-characteristics-critical-for-comparative-effectiveness-research
#15
Kueiyu Joshua Lin, Robert J Glynn, Daniel E Singer, Shawn N Murphy, Joyce Lii, Sebastian Schneeweiss
BACKGROUND: It is unclear how out-of-system care or electronic health record (EHR) discontinuity (i.e., receiving care outside of an EHR system) may affect validity of comparative effectiveness research using these data. We aimed to compare the misclassification of key variables in patients with high vs. low EHR-continuity. METHODS: The study cohort comprised patients aged ≥65 identified in electronic health records from two US provider networks linked with Medicare insurance claims data from 2007-2014...
December 26, 2017: Epidemiology
https://www.readbyqxmd.com/read/29274616/integrating-social-justice-concerns-into-economic-evaluation-for-healthcare-and-public-health-a-systematic-review
#16
Vadim Dukhanin, Alexandra Searle, Alice Zwerling, David W Dowdy, Holly A Taylor, Maria W Merritt
Social justice is the moral imperative to avoid and remediate unfair distributions of societal disadvantage. In priority setting in healthcare and public health, social justice reaches beyond fairness in the distribution of health outcomes and economic impacts to encompass fairness in the distribution of policy impacts upon other dimensions of well-being. There is an emerging awareness of the need for economic evaluation to integrate all such concerns. We performed a systematic review (1) to describe methodological solutions suitable for integrating social justice concerns into economic evaluation, and (2) to describe the challenges that those solutions face...
December 14, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29274073/investigation-of-the-use-of-a-family-health-history-application-in-genetic-counseling
#17
Meghan L Tipsword, Peter S White, Christine G Spaeth, Richard F Ittenbach, Melanie F Myers
The paper-based pedigree is the current standard for family health history (FHH) documentation in genetic counseling. Several tools for electronic capture of family health data have been developed to improve re-use and accessibility, data quality and standardization, ease of updating, and integration with electronic medical records. One such tool, the tablet-based Proband application, provides a flexible approach to data capture in dynamic and diverse clinical settings. This study compared Proband FHH collection to paper-based methods and investigated the usability of Proband in a clinical setting...
December 22, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29232325/utility-of-electronic-medical-records-in-community-rheumatology-practice-for-assessing-quality-of-care-indicators-for-gout-a-feasibility-study
#18
Augusto Estrada, Nicole W Tsao, Alyssa Howren, John M Esdaile, Kamran Shojania, Mary A De Vera
OBJECTIVES: With comprehensive capture of information on patient encounters, electronic medical records (EMRs) may have utility for assessing adherence to quality indicators (QIs) in gout. Our objectives were to translate 10 previously established gout QIs into relevant EMR data and evaluate and describe the feasibility of using EMRs to assess gout QIs. METHODS: Using EMRs from 3 community rheumatology practices in Vancouver, British Columbia, Canada, we identified gout patients seen between January 1, 2012, and December 31, 2013...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29230493/the-limitations-of-some-european-healthcare-databases-for-monitoring-the-effectiveness-of-pregnancy-prevention-programmes-as-risk-minimisation-measures
#19
R A Charlton, V Bettoli, H J Bos, A Engeland, E Garne, R Gini, A V Hansen, L T W de Jong-van den Berg, S Jordan, K Klungsøyr, A J Neville, A Pierini, A Puccini, M Sinclair, D Thayer, H Dolk
PURPOSE: Pregnancy prevention programmes (PPPs) exist for some medicines known to be highly teratogenic. It is increasingly recognised that the impact of these risk minimisation measures requires periodic evaluation. This study aimed to assess the extent to which some of the data needed to monitor the effectiveness of PPPs may be present in European healthcare databases. METHODS: An inventory was completed for databases contributing to EUROmediCAT capturing pregnancy and prescription data in Denmark, Norway, the Netherlands, Italy (Tuscany/Emilia Romagna), Wales and the rest of the UK, to determine the extent of data collected that could be used to evaluate the impact of PPPs...
December 11, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29229988/dietary-habits-and-cooking-methods-could-reduce-avoidable-exposure-to-pcbs-in-maternal-and-cord-sera
#20
Weiwei Jin, Masae Otake, Akifumi Eguchi, Kenichi Sakurai, Hiroko Nakaoka, Masahiro Watanabe, Emiko Todaka, Chisato Mori
Polychlorinated biphenyls (PCBs), like other persistent organic pollutants, are accumulating throughout the food chain and pose health threats to humans, especially children and foetuses. There is no protocol for reducing the contamination levels of the PCBs in humans. This study identified food items and cooking methods that reduce serum PCB levels by analysing data collected from the Chiba Study of Mother and Child Health. The sample size was 194 subjects. Serum PCB levels were measured using gas chromatography-electron capture negative ionization quadrupole mass spectrometry...
December 11, 2017: Scientific Reports
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