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https://www.readbyqxmd.com/read/28913330/resurgence-of-diphtheria-in-north-kerala-india-2016-laboratory-supported-case-based-surveillance-outcomes
#1
Lucky Sangal, Sudhir Joshi, Shalini Anandan, Veeraraghavan Balaji, Jaichand Johnson, Asish Satapathy, Pradeep Haldar, Ramesh Rayru, Srinath Ramamurthy, Asha Raghavan, Pankaj Bhatnagar
INTRODUCTION: As part of national program, laboratory supported vaccine preventable diseases surveillance was initiated in Kerala in 2015. Mechanisms have been strengthened for case investigation, reporting, and data management. Specimens collected and sent to state and reference laboratories for confirmation and molecular surveillance. The major objective of this study is to understand the epidemiological information generated through surveillance system and its utilization for action...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28903894/prototype-development-context-driven-dynamic-xml-ophthalmologic-data-capture-application
#2
Peggy Peissig, Kelsey M Schwei, Christopher Kadolph, Joseph Finamore, Efrain Cancel, Catherine A McCarty, Asha Okorie, Kate L Thomas, Jennifer Allen Pacheco, Jyotishman Pathak, Stephen B Ellis, Joshua C Denny, Luke V Rasmussen, Gerard Tromp, Marc S Williams, Tamara R Vrabec, Murray H Brilliant
BACKGROUND: The capture and integration of structured ophthalmologic data into electronic health records (EHRs) has historically been a challenge. However, the importance of this activity for patient care and research is critical. OBJECTIVE: The purpose of this study was to develop a prototype of a context-driven dynamic extensible markup language (XML) ophthalmologic data capture application for research and clinical care that could be easily integrated into an EHR system...
September 13, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28903869/interventions-to-reduce-non-typhoidal-salmonella-in-pigs-during-transport-to-slaughter-and-lairage-systematic-review-meta-analysis-and-research-synthesis-based-infection-models-in-support-of-assessment-of-effectiveness
#3
REVIEW
Barbara J Wilhelm, Ian Young, Sarah Cahill, Patricia Desmarchelier, Rei Nakagawa, Andrijana Rajić
A systematic review of the effectiveness of interventions to reduce Salmonella prevalence or concentration in pork was undertaken. A broad search was conducted in two electronic databases. Each citation was appraised using screening tools designed and tested a priori. Level 1 relevance screening excluded irrelevant citations; level 2 confirmed relevance and categorized. Data were then extracted, and intervention categories were descriptively summarized. Meta-analysis was performed to provide a summary estimate of treatment effect where two or more studies investigated the same intervention in comparable populations...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28900171/mechanistic-insight-into-internal-conversion-process-within-q-bands-of-chlorophyll-a
#4
Elena Meneghin, Cristina Leonardo, Andrea Volpato, Luca Bolzonello, Elisabetta Collini
The non-radiative relaxation of the excitation energy from higher energy states to the lowest energy state in chlorophylls is a crucial preliminary step for the process of photosynthesis. Despite the continuous theoretical and experimental efforts to clarify the ultrafast dynamics of this process, it still represents the object of an intense investigation because the ultrafast timescale and the congestion of the involved states makes its characterization particularly challenging. Here we exploit 2D electronic spectroscopy and recently developed data analysis tools to provide more detailed insights into the mechanism of internal conversion within the Q-bands of chlorophyll a...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893811/tethered-to-the-ehr-primary-care-physician-workload-assessment-using-ehr-event-log-data-and-time-motion-observations
#5
Brian G Arndt, John W Beasley, Michelle D Watkinson, Jonathan L Temte, Wen-Jan Tuan, Christine A Sinsky, Valerie J Gilchrist
PURPOSE: Primary care physicians spend nearly 2 hours on electronic health record (EHR) tasks per hour of direct patient care. Demand for non-face-to-face care, such as communication through a patient portal and administrative tasks, is increasing and contributing to burnout. The goal of this study was to assess time allocated by primary care physicians within the EHR as indicated by EHR user-event log data, both during clinic hours (defined as 8:00 am to 6:00 pm Monday through Friday) and outside clinic hours...
September 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28885753/study-of-gas-phase-reactions-of-no2-with-aromatic-compounds-using-proton-transfer-reaction-time-of-flight-mass-spectrometry
#6
Jianquan Li, Xubing Du, Teng Guo, Zhen Peng, Li Xu, Junguo Dong, Ping Cheng, Zhen Zhou
The study of ion chemistry involving the NO2(+) is currently the focus of considerable fundamental interest and is relevant in diverse fields ranging from mechanistic organic chemistry to atmospheric chemistry. A very intense source of NO2(+) was generated by injecting the products from the dielectric barrier discharge (DBD) of a nitrogen and oxygen mixture upstream into the drift tube of a proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS) apparatus with H3 O(+) as the reagent ion. The NO2(+) intensity is controllable and related to the DBD operation conditions and ratio of oxygen to nitrogen...
September 8, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28883178/automated-transformation-of-cdisc-odm-to-openclinica
#7
Sophia Gessner, Michael Storck, Stefan Hegselmann, Martin Dugas, Iñaki Soto-Rey
Due to the increasing use of electronic data capture systems for clinical research, the interest in saving resources by automatically generating and reusing case report forms in clinical studies is growing. OpenClinica, an open-source electronic data capture system enables the reuse of metadata in its own Excel import template, hampering the reuse of metadata defined in other standard formats. One of these standard formats is the Operational Data Model for metadata, administrative and clinical data in clinical studies...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28876686/management-of-failed-mitral-valve-replacement-the-durban-experience
#8
D Kistan, M Booysen, G Alexander, T E Madiba
BACKGROUND: Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve-related complications. METHOD: Study setting: Inkosi Albert Luthuli Central Hospital, a tertiary referral Hospital in Durban. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January 2005 and December 2014...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876670/foley-catheter-balloon-tamponade-fcbt-for-penetrating-neck-injuries-pni-at-groote-schuur-hospital-an-update
#9
M F Scriba, P H Navsaria, A J Nicol, S Edu, A Al-Sayari
BACKGROUND: A previous study from Groote Schuur Hospital (GSH) highlighted the success of FCBT (PNI). METHOD: The records of all patients with PNI requiring FCBT for a neck injury presenting to GSH within an 11-month study period were reviewed. Prospectively captured data on the Electronic Trauma Health Record Application (eTHRApp), was retrospectively analysed. Analysed data included demographics, clinical signs on admission, imaging, management and major outcomes...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876577/surgical-burden-of-disease-at-a-regional-hospital-in-south-africa
#10
O Swart, J Pape, R Duvenage
BACKGROUND: There is limited published data describing the nature of surgical admissions at a regional level in the South African context. Worcester Hospital General Surgery has introduced an electronic online database to manage its surgical services. This study uses that database to evaluate the surgical burden of disease for the Cape Winelands East and Overberg districts of the Western Cape. METHOD: Admissions data were prospectively captured from February 2012 to January 2016, then retrospectively reviewed and classified into 5 types: (1) elective surgery/investigations (ESI); (2) trauma; (3) burns; (4) non-traumatic surgical emergencies (NTSE); (5) unplanned readmission within 30 days...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874317/generalized-paroxysmal-fast-activity-in-eeg-an-unrecognized-finding-in-genetic-generalized-epilepsy
#11
Vishwanath Sagi, Inyup Kim, Amar B Bhatt, Hasan Sonmezturk, Bassel W Abou-Khalil, Amir M Arain
OBJECTIVE: To study generalized paroxysmal fast activity (GPFA) in patients with genetic generalized epilepsy (GGE). INTRODUCTION: GPFA is an electroencephalographic (EEG) finding in patients with symptomatic generalized epilepsy consisting of 15-25Hz bifrontally predominant generalized fast activity seen predominantly in sleep. Historically GPFA is linked to epileptic encephalopathy with drug resistant epilepsy and intellectual disability. However, GPFA has been rarely described as an atypical finding in patients with GGE without negative prognostic implication...
September 2, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28872109/measurements-of-soil-carbon-by-neutron-gamma-analysis-in-static-and-scanning-modes
#12
Galina Yakubova, Aleksandr Kavetskiy, Stephen A Prior, H Allen Torbert
The herein described application of the inelastic neutron scattering (INS) method for soil carbon analysis is based on the registration and analysis of gamma rays created when neutrons interact with soil elements. The main parts of the INS system are a pulsed neutron generator, NaI(Tl) gamma detectors, split electronics to separate gamma spectra due to INS and thermo-neutron capture (TNC) processes, and software for gamma spectra acquisition and data processing. This method has several advantages over other methods in that it is a non-destructive in situ method that measures the average carbon content in large soil volumes, is negligibly impacted by local sharp changes in soil carbon, and can be used in stationary or scanning modes...
August 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28866586/eventthread-visual-summarization-and-stage-analysis-of-event-sequence-data
#13
Shunan Guo, Ke Xu, Rongwen Zhao, David Gotz, Hongyuan Zha, Nan Cao
Event sequence data such as electronic health records, a person's academic records, or car service records, are ordered series of events which have occurred over a period of time. Analyzing collections of event sequences can reveal common or semantically important sequential patterns. For example, event sequence analysis might reveal frequently used care plans for treating a disease, typical publishing patterns of professors, and the patterns of service that result in a well-maintained car. It is challenging, however, to visually explore large numbers of event sequences, or sequences with large numbers of event types...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28865143/identifying-patients-with-high-data-completeness-to-improve-validity-of-comparative-effectiveness-research-in-electronic-health-records-data
#14
Kueiyu Joshua Lin, Daniel E Singer, Robert J Glynn, Shawn N Murphy, Joyce Lii, Sebastian Schneeweiss
Electronic health records (EHR)-discontinuity, i.e., having medical information recorded outside of the study EHR system, is associated with substantial information bias in EHR-based comparative effectiveness research (CER). We aimed to develop and validate a prediction model identifying patients with high EHR-continuity to reduce this bias. Based on 183,739 patients aged ≥65 in EHRs from two US provider networks linked with Medicare claims data from 2007-2014, we quantified EHR-continuity by Mean Proportion of Encounters Captured (MPEC) by the EHR system...
September 2, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28862758/fremanezumab-as-add-on-treatment-for-patients-treated-with-other-migraine-preventive-medicines
#15
Joshua M Cohen, David W Dodick, Ronghua Yang, Lawrence C Newman, Thomas Li, Ernesto Aycardi, Marcelo E Bigal
BACKGROUND: Fremanezumab (formerly TEV-48125) is a monoclonal antibody directed against calcitonin-gene-related peptide (CGRP), a validated target for migraine preventive therapy. In two previous phase 2 studies, fremanezumab administered once every 28 days for 12 weeks was found to be effective and safe as a preventive treatment for patients suffering from episodic migraine (EM) and chronic migraine (CM). OBJECTIVE: To evaluate the efficacy and safety of fremanezumab as an add-on preventive therapy in individuals with EM and CM who are on stable doses of preventive migraine medications...
September 1, 2017: Headache
https://www.readbyqxmd.com/read/28861588/efficient-genome-wide-association-in-biobanks-using-topic-modeling-identifies-multiple-novel-disease-loci
#16
Thomas H McCoy, Victor M Castro, Leslie A Snapper, Kamber L Hart, Roy H Perlis
Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that may be unreliable and fail to capture the relationship between related diagnoses. We developed an efficient means of conducting genome-wide association studies using combinations of diagnostic codes from electronic health records (EHR) for 10845 participants in a biobanking program at two large academic medical centers. Specifically, we applied latent Dirichilet allocation to fit 50 disease topics based on diagnostic codes, then conducted genome-wide common-variant association for each topic...
August 31, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28859942/a-multifaceted-intervention-to-improve-treatment-with-oral-anticoagulants-in-atrial-fibrillation-impact-af-an-international-cluster-randomised-trial
#17
Dragos Vinereanu, Renato D Lopes, M Cecilia Bahit, Denis Xavier, Jie Jiang, Hussein R Al-Khalidi, Wensheng He, Ying Xian, Andrea O Ciobanu, Deepak Y Kamath, Kathleen A Fox, Meena P Rao, Sean D Pokorney, Otavio Berwanger, Carlos Tajer, Pedro G M de Barros E Silva, Mayme L Roettig, Yong Huo, Christopher B Granger
BACKGROUND: Oral anticoagulation is underused in patients with atrial fibrillation. We assessed the impact of a multifaceted educational intervention, versus usual care, on oral anticoagulant use in patients with atrial fibrillation. METHODS: This study was a two-arm, prospective, international, cluster-randomised, controlled trial. Patients were included who had atrial fibrillation and an indication for oral anticoagulation. Clusters were randomised (1:1) to receive a quality improvement educational intervention (intervention group) or usual care (control group)...
August 25, 2017: Lancet
https://www.readbyqxmd.com/read/28857014/implementation-of-a-sensemaker%C3%A2-research-project-among-syrian-refugees-in-lebanon
#18
Nour Bakhache, Saja Michael, Sophie Roupetz, Stephanie Garbern, Harveen Bergquist, Colleen Davison, Susan Bartels
The Syrian conflict has displaced over 1.2 million Syrians into Lebanon. As a result of displacement, some Syrian families are turning to child marriage as a coping mechanism. The prevalence of early marriage has reportedly increased and the average age of marriage decreased during the crisis. The aim of the project was to understand the underlying factors contributing to child marriage among Syrian refugees in Lebanon using Cognitive Edge's SenseMaker®. This manuscript explores the process of implementing this novel research tool in a humanitarian setting...
2017: Global Health Action
https://www.readbyqxmd.com/read/28855245/the-promise-of-digital-mood-tracking-technologies-are-we-heading-on-the-right-track
#19
REVIEW
Gin S Malhi, Amber Hamilton, Grace Morris, Zola Mannie, Pritha Das, Tim Outhred
The growing understanding that mood disorders are dynamic in nature and fluctuate over variable epochs of time has compelled researchers to develop innovative methods of monitoring mood. Technological advancement now allows for the detection of minute-to-minute changes while also capturing a longitudinal perspective of an individual's illness. Traditionally, assessments of mood have been conducted by means of clinical interviews and paper surveys. However, these methods are often inaccurate due to recall bias and compliance issues, and are limited in their capacity to collect and process data over long periods of time...
August 30, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28853764/exploring-vital-sign-data-quality-in-electronic-health-records-with-focus-on-emergency-care-warning-scores
#20
Niclas Skyttberg, Rong Chen, Hans Blomqvist, Sabine Koch
BACKGROUND: Computerized clinical decision support and automation of warnings have been advocated to assist clinicians in detecting patients at risk of physiological instability. To provide reliable support such systems are dependent on high-quality vital sign data. Data quality depends on how, when and why the data is captured and/or documented. OBJECTIVES: This study aims to describe the effects on data quality of vital signs by three different types of documentation practices in five Swedish emergency hospitals, and to assess data fitness for calculating warning and triage scores...
August 30, 2017: Applied Clinical Informatics
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