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https://www.readbyqxmd.com/read/29776525/ability-to-monitor-driving-under-the-influence-of-marijuana-among-non-fatal-motor-vehicle-crashes-an-evaluation-of-the-colorado-electronic-accident-reporting-system
#1
Alexis B Peterson, Erin K Sauber-Schatz, Karin A Mack
INTRODUCTION: As more states legalize medical/recreational marijuana use, it is important to determine if state motor-vehicle surveillance systems can effectively monitor and track driving under the influence (DUI) of marijuana. This study assessed Colorado's Department of Revenue motor-vehicle crash data system, Electronic Accident Reporting System (EARS), to monitor non-fatal crashes involving driving under the influence (DUI) of marijuana. METHODS: Centers for Disease Control and Prevention guidelines on surveillance system evaluation were used to assess EARS' usefulness, flexibility, timeliness, simplicity, acceptability, and data quality...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29770910/creation-and-implementation-of-an-environmental-scan-to-assess-cancer-genetics-services-at-three-oncology-care-settings
#2
Erica M Bednar, Michael T Walsh, Ellen Baker, Kimberly I Muse, Holly D Oakley, Rebekah C Krukenberg, Cara S Dresbold, Sandra B Jenkinson, Amanda L Eppolito, Kelly B Teed, Molly H Klein, Nichole A Morman, Elizabeth C Bowdish, Pauline Russ, Emaline E Wise, Julia N Cooper, Michael W Method, John W Henson, Andrew V Grainger, Banu K Arun, Karen H Lu
An environmental scan (ES) is an efficient mixed-methods approach to collect and interpret relevant data for strategic planning and project design. To date, the ES has not been used nor evaluated in the clinical cancer genetics setting. We created and implemented an ES to inform the design of a quality improvement (QI) project to increase the rates of adherence to national guidelines for cancer genetic counseling and genetic testing at three unique oncology care settings (OCS). The ES collected qualitative and quantitative data from reviews of internal processes, past QI efforts, the literature, and each OCS...
May 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29770093/canada-s-pandemic-influenza-preparedness-surveillance-strategy
#3
B Henry
The Canadian Pandemic Influenza Preparedness: Planning Guidance for the Health Sector (CPIP) is a guidance document that outlines key health sector preparedness activities designed to ensure Canada is ready to respond to the next influenza pandemic. This article outlines Canada's pandemic influenza surveillance strategy as described in the CPIP Surveillance Annex . The strategy builds on the surveillance activities used for seasonal influenza and incorporates lessons learned from the 2009 H1N1 pandemic, including improved information sharing, improved electronic links among federal, provincial and territorial (FPT) partners and improved surveillance for Indigenous communities...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29766224/stable-and-enriched-cenarchaeum-symbiosum-and-uncultured-betaproteobacteria-hf1-in-the-microbiome-of-the-mediterranean-sponge-haliclona-fulva-demospongiae-haplosclerida
#4
Erika García-Bonilla, Pedro F B Brandão, Thierry Pérez, Howard Junca
Sponges harbor characteristic microbiomes derived from symbiotic relationships shaping their lifestyle and survival. Haliclona fulva is encrusting marine sponge species dwelling in coralligenous accretions or semidark caves of the Mediterranean Sea and the near Atlantic Ocean. In this work, we characterized the abundance and core microbial community composition found in specimens of H. fulva by means of electron microscopy and 16S amplicon Illumina sequencing. We provide evidence of its low microbial abundance (LMA) nature...
May 15, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29764476/traumatic-brain-injury-in-uganda-exploring-the-use-of-a-hospital-based-registry-for-measuring-burden-and-outcomes
#5
Amber Mehmood, Nukhba Zia, Connie Hoe, Olive Kobusingye, Hussein Ssenyojo, Adnan A Hyder
OBJECTIVE: Lack of data on traumatic brain injuries (TBI) hinders the appreciation of the true magnitude of the TBI burden. This paper describes a scientific approach for hospital based systematic data collection in a low-income country. The registry is based on the evaluation framework for injury surveillance systems which comprises a four-step approach: (1) identifying characteristics that assess a surveillance system, (2) review of the identified variables based on adopted specific, measurable, assignable, realistic, and time-related criteria, (3) assessment of the proposed variables and system characteristics by an expert panel, and (4) development and application of a rating system...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29762887/the-underreporting-of-medication-errors-a-retrospective-and-comparative-root-cause-analysis-in-an-acute-mental-health-unit-over-a-3-year-period
#6
Maeve Morrison, Vicki Cope, Melanie Murray
Medication errors remain a commonly reported clinical incident in health care as highlighted by the World Health Organization's focus to reduce medication-related harm. This retrospective quantitative analysis examined medication errors reported by staff using an electronic Clinical Incident Management System (CIMS) during a 3-year period from April 2014 to April 2017 at a metropolitan mental health ward in Western Australia. The aim of the project was to identify types of medication errors and the context in which they occur and to consider recourse so that medication errors can be reduced...
May 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29760941/hip-fracture-in-the-elderly-multidisciplinary-rehabilitation-femur-feasibility-study-testing-the-use-of-routinely-collected-data-for-future-health-economic-evaluations
#7
Nefyn H Williams, Kevin Mawdesley, Jessica L Roberts, Nafees Ud Din, Nicola Totton, Joanna M Charles, Zoe Hoare, Rhiannon T Edwards
Background: Health economic evaluations rely on the accurate measurement of health service resource use in order to calculate costs. These are usually measured with patient completed questionnaires using instruments such as the Client Service Receipt Inventory (CSRI). These rely on participants' recall and can be burdensome to complete. Health service activity data are routinely captured by electronic databases.The aim was to test methods for obtaining these data and compare with those data collected using the CSRI, within a feasibility study of an enhanced rehabilitation intervention following hip fracture (Fracture in the Elderly Multidisciplinary Rehabilitation: FEMuR)...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29756218/tyrosine-absorption-spectroscopy-backbone-protonation-effects-on-the-side-chain-electronic-properties
#8
Sara Del Galdo, Giordano Mancini, Isabella Daidone, Laura Zanetti Polzi, Andrea Amadei, Vincenzo Barone
The UV-vis spectrum of Tyrosine and its response to different backbone protonation states have been studied by applying the Perturbed Matrix Method (PMM) in conjunction with molecular dynamics (MD) simulations. Herein, we theoretically reproduce the UV-vis absorption spectrum of aqueous solution of Tyrosine in its zwitterionic, anionic and cationic forms, as well as of aqua-p-Cresol (i.e., the moiety that constitutes the side chain portion of Tyrosine). To achieve a better accuracy in the MD sampling, the Tyrosine Force Field (FF) parameters were derived de novo via quantum mechanical calculations...
May 14, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29754648/the-cvad-registry-for-percutaneous-temporary-hemodynamic-support-a-prospective-registry-of-impella-mechanical-circulatory-support-use-in-high-risk-pci-cardiogenic-shock-and-decompensated-heart-failure
#9
George W Vetrovec, Mark Anderson, Theodore Schreiber, Jeffrey Popma, William Lombardi, Brijeshwar Maini, Jacob Eifer Moller, Andreas Schäfer, Simon R Dixon, Shelley Hall, E Magnus Ohman, Catalin Mindrescu, Jeffrey Moses, William O'Neill
Management of patients requiring temporary, mechanical hemodynamic support during high- risk percutaneous coronary intervention (PCI) or in cardiogenic shock is rapidly evolving. With the availability of the Impella 2.5, CP, 5.0, LD, and RP percutaneous mechanical circulatory support devices, there is a need for continued surveillance of outcomes. Three factors underline the importance of a registry for these populations. First, large randomized trials of hemodynamic support, involving cardiogenic shock, are challenging to conduct...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29750566/advanced-age-results-in-a-diminished-endothelial-glycocalyx
#10
Daniel R Machin, Samuel I Bloom, Robert A Campbell, Tam T T Phuong, Phillip Ellis Gates, Lisa A Lesniewski, Matthew T Rondina, Anthony John Donato
Age-related microvascular dysfunction is well characterized in rodents and humans, but little is known about the properties of the microvascular endothelial glycocalyx in advanced age. We examined the glycocalyx in microvessels of young and old C57BL6 mice (young: 6.1{plus minus}0.1 vs old: 24.6{plus minus}0.2 mo) using intravital microscopy and transmission electron microscopy, and in human participants (young: 27{plus minus}1 vs old: 61{plus minus}2 yr) using intravital microscopy. Glycocalyx thickness in mesenteric and skeletal muscle microvessels was 51-54% lower in old, compared to young mice...
May 11, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29749918/operative-and-consultative-proportions-of-neurosurgical-disease-worldwide-estimation-from-the-surgeon-perspective
#11
Michael C Dewan, Abbas Rattani, Ronnie E Baticulon, Serena Faruque, Walter D Johnson, Robert J Dempsey, Michael M Haglund, Blake C Alkire, Kee B Park, Benjamin C Warf, Mark G Shrime
OBJECTIVE The global magnitude of neurosurgical disease is unknown. The authors sought to estimate the surgical and consultative proportion of diseases commonly encountered by neurosurgeons, as well as surgeon case volume and perceived workload. METHODS An electronic survey was sent to 193 neurosurgeons previously identified via a global surgeon mapping initiative. The survey consisted of three sections aimed at quantifying surgical incidence of neurological disease, consultation incidence, and surgeon demographic data...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29733723/real-world-evidence-in-support-of-precision-medicine-clinico-genomic-cancer-data-as-a-case-study
#12
Vineeta Agarwala, Sean Khozin, Gaurav Singal, Claire O'Connell, Deborah Kuk, Gerald Li, Anala Gossai, Vincent Miller, Amy P Abernethy
The majority of US adult cancer patients today are diagnosed and treated outside the context of any clinical trial (that is, in the real world). Although these patients are not part of a research study, their clinical data are still recorded. Indeed, data captured in electronic health records form an ever-growing, rich digital repository of longitudinal patient experiences, treatments, and outcomes. Likewise, genomic data from tumor molecular profiling are increasingly guiding oncology care. Linking real-world clinical and genomic data, as well as information from other co-occurring data sets, could create study populations that provide generalizable evidence for precision medicine interventions...
May 2018: Health Affairs
https://www.readbyqxmd.com/read/29732166/secondary-use-of-electronic-medical-records-for-clinical-research-challenges-and-opportunities
#13
Wen-Wai Yim, Amanda J Wheeler, Catherine Curtin, Todd H Wagner, Tina Hernandez-Boussard
With increasingly ubiquitous electronic medical record (EMR) implementation accelerated by the adoption of the HITECH Act, there is much interest in the secondary use of collected data to improve outcomes and promote personalized medicine. A plethora of research has emerged using EMRs to investigate clinical research questions and assess variations in both treatments and outcomes. However, whether because of genuine complexities of modeling disease physiology or because of practical problems regarding data capture, data accuracy, and data completeness, the state of current EMR research is challenging and gives rise to concerns regarding study accuracy and reproducibility...
March 2018: Convergent Science Physical Oncology
https://www.readbyqxmd.com/read/29727463/chlamydia-exploits-filopodial-capture-and-a-macropinocytosis-like-pathway-for-host-cell-entry
#14
Charlotte Ford, Andrea Nans, Emmanuel Boucrot, Richard D Hayward
Pathogens hijack host endocytic pathways to force their own entry into eukaryotic target cells. Many bacteria either exploit receptor-mediated zippering or inject virulence proteins directly to trigger membrane reorganisation and cytoskeletal rearrangements. By contrast, extracellular C. trachomatis elementary bodies (EBs) apparently employ facets of both the zipper and trigger mechanisms and are only ~400 nm in diameter. Our cryo-electron tomography of C. trachomatis entry revealed an unexpectedly diverse array of host structures in association with invading EBs, suggesting internalisation may progress by multiple, potentially redundant routes or several sequential events within a single pathway...
May 4, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29725648/nephcure-accelerating-cures-institute-a-multidisciplinary-consortium-to-improve-care-for-nephrotic-syndrome
#15
Debbie S Gipson, David T Selewski, Susan F Massengill, Mary Margaret Modes, Hailey Desmond, Lauren Lee, Elaine Kamil, Matthew R Elliott, Sharon G Adler, Gia Oh, Richard A Lafayette, Patrick E Gipson, Aditi Sinha, Arvind Bagga, Anne Pesenson, Cheryl Courtlandt, Cathie Spino, Richard Eikstadt, Renée Pitter, Samara Attalla, Anne Waldo, Richard Winneker, Noelle E Carlozzi, Jonathan P Troost, Irving Smokler, Mark Stone
Introduction: NephCure Accelerating Cures Institute (NACI) is a collaborative organization sponsored by NephCure Kidney International and the University of Michigan. The Institute is composed of 7 cores designed to improve treatment options and outcomes for patients with glomerular disease: Clinical Trials Network, Data Warehouse, Patient-Reported Outcomes (PRO) and Endpoints Consortium, Clinical Trials Consulting Team, Quality Initiatives, Education and Engagement, and Data Coordinating Center...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29720153/identifying-diabetes-cases-from-administrative-data-a-population-based-validation-study
#16
Lorraine L Lipscombe, Jeremiah Hwee, Lauren Webster, Baiju R Shah, Gillian L Booth, Karen Tu
BACKGROUND: Health care data allow for the study and surveillance of chronic diseases such as diabetes. The objective of this study was to identify and validate optimal algorithms for diabetes cases within health care administrative databases for different research purposes, populations, and data sources. METHODS: We linked health care administrative databases from Ontario, Canada to a reference standard of primary care electronic medical records (EMRs). We then identified and calculated the performance characteristics of multiple adult diabetes case definitions, using combinations of data sources and time windows...
May 2, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29717911/epidemiology-of-trauma-related-infections-among-a-combat-casualty-cohort-after-initial-hospitalization-the-trauma-infectious-disease-outcomes-study
#17
David R Tribble, Margot R Krauss, Clinton K Murray, Tyler E Warkentien, Bradley A Lloyd, Anuradha Ganesan, Lauren Greenberg, Jiahong Xu, Ping Li, M Leigh Carson, William Bradley, Amy C Weintrob
BACKGROUND: The Trauma Infectious Disease Outcomes Study (TIDOS) cohort follows military personnel with deployment-related injuries in order to evaluate short- and long-term infectious complications. High rates of infectious complications have been observed in more than 30% of injured patients during initial hospitalization. We present data on infectious complications related to combat trauma after the initial period of hospitalization. PATIENTS AND METHODS: Data related to patient care for military personnel injured during combat operations between June 2009 and May 2012 were collected...
May 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29714600/baseline-assessment-of-the-evolving-2017-eclinical-landscape
#18
Michael Wilkinson, Richard Young, Beth Harper, Brittany Machion, Ken Getz
The volume and diversity of data collected to support each clinical study has increased dramatically in response to the rising scope and complexity of global drug development programs. The Tufts Center for the Study of Drug Development conducted an online survey of 257 unique global companies-77% drug development sponsors and 23% contract service providers-to assess clinical data management practices and experiences. Study results indicate that companies are using an average of 6 different applications to support each clinical study and that companies are collecting a range of data types including that from case report forms, lab procedures, pharmacokinetics, biomarker, outcomes assessment, mobile health, and social media...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29713354/severe-eosinophilic-asthma-in-primary-care-in-canada-a-longitudinal-study-of-the-clinical-burden-and-economic-impact-based-on-linked-electronic-medical-record-data
#19
Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier, Alain Gendron
Background: Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This study characterized patients with severe asthma who could qualify for these biologics in a primary care setting. Methods: We retrospectively selected patients from July 1, 2010, to June 30, 2014, using a linked electronic medical records (EMR) database (IMS Evidence 360 EMR Canada) for > 950,000 patients in primary care in Ontario, Canada...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29710218/fertility-and-birth-outcomes-in-women-with-epilepsy-seeking-pregnancy
#20
Page B Pennell, Jacqueline A French, Cynthia L Harden, Anne Davis, Emilia Bagiella, Evie Andreopoulos, Connie Lau, Nichelle Llewellyn, Sarah Barnard, Stephanie Allien
Importance: Prior studies report lower birth rates for women with epilepsy (WWE) but have been unable to differentiate between biological and social contributions. To our knowledge, we do not have data to inform WWE seeking pregnancy if their likelihood of achieving pregnancy is biologically reduced compared with their peers. Objective: To determine if WWE without a prior diagnosis of infertility or related disorders are as likely to achieve pregnancy within 12 months as their peers without epilepsy...
April 30, 2018: JAMA Neurology
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