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https://www.readbyqxmd.com/read/28789686/developing-a-cardiovascular-disease-risk-factor-annotated-corpus-of-chinese-electronic-medical-records
#1
Jia Su, Bin He, Yi Guan, Jingchi Jiang, Jinfeng Yang
BACKGROUND: Cardiovascular disease (CVD) has become the leading cause of death in China, and most of the cases can be prevented by controlling risk factors. The goal of this study was to build a corpus of CVD risk factor annotations based on Chinese electronic medical records (CEMRs). This corpus is intended to be used to develop a risk factor information extraction system that, in turn, can be applied as a foundation for the further study of the progress of risk factors and CVD. RESULTS: We designed a light annotation task to capture CVD risk factors with indicators, temporal attributes and assertions that were explicitly or implicitly displayed in the records...
August 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28780187/validation-of-a-smart-shoe-for-estimating-foot-progression-angle-during-walking-gait
#2
Haisheng Xia, Junkai Xu, Jianren Wang, Michael A Hunt, Peter B Shull
The foot progression angle is an important measurement related to knee loading, pain, and function for individuals with knee osteoarthritis, however current measurement methods require camera-based motion capture or floor-embedded force plates confining foot progression angle assessment to facilities with specialized equipment. This paper presents the validation of a customized smart shoe for estimating foot progression angle during walking. The smart shoe is composed of an electronic module with inertial and magnetometer sensing inserted into the sole of a standard walking shoe...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28771322/characterization-of-ligand-shell-for-mixed-ligand-coated-gold-nanoparticles
#3
Quy Ong, Zhi Luo, Francesco Stellacci
Gold nanoparticles owe a large number of their properties to their ligand shell. Indeed, many researchers routinely use mixtures of ligand molecules for their nanoparticles to impart complex property sets. It has been shown that the morphology of ligand shells (e.g., Janus, random, stripelike) leads to specific properties. Examples include wettability, solubility, protein nonspecific adsorption, cell penetration, catalysis, and cation-capturing abilities. Yet, it remains a great challenge to evaluate such morphologies in even the most fundamental terms such as dimension and shape...
August 3, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28766206/the-american-society-of-breast-surgeons-and-quality-payment-programs-ranking-defining-and-benchmarking-more-than-1-million-patient-quality-measure-encounters
#4
Jeffrey Landercasper, Lisa Bailey, Robert Buras, Ed Clifford, Amy C Degnim, Leila Thanasoulis, Oluwadamilola M Fayanju, Judy A Tjoe, Roshni Rao
BACKGROUND: To identify and remediate gaps in the quality of surgical care, the American Society of Breast Surgeons (ASBrS) developed surgeon-specific quality measures (QMs), built a patient registry, and nominated itself to become a Center for Medicare and Medicaid Services (CMS) Qualified Clinical Data Registry (QCDR), thereby linking surgical performance to potential reimbursement and public reporting. This report provides a summary of the program development. METHODS: Using a modified Delphi process, more than 100 measures of care quality were ranked...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28763505/impact-of-a-district-wide-health-center-strengthening-intervention-on-healthcare-utilization-in-rural-rwanda-use-of-interrupted-time-series-analysis
#5
Hari S Iyer, Lisa R Hirschhorn, Marie Paul Nisingizwe, Emmanuel Kamanzi, Peter C Drobac, Felix C Rwabukwisi, Michael R Law, Andrew Muhire, Vincent Rusanganwa, Paulin Basinga
BACKGROUND: Evaluations of health systems strengthening (HSS) interventions using observational data are rarely used for causal inference due to limited data availability. Routinely collected national data allow use of quasi-experimental designs such as interrupted time series (ITS). Rwanda has invested in a robust electronic health management information system (HMIS) that captures monthly healthcare utilization data. We used ITS to evaluate impact of an HSS intervention to improve primary health care facility readiness on health service utilization in two rural districts of Rwanda...
2017: PloS One
https://www.readbyqxmd.com/read/28757349/improved-calculations-of-electron-capture-transitions-for-decay-data-and-radionuclide-metrology
#6
X Mougeot
Electron capture properties are crucial to establish the decay schemes of numerous radionuclides. The present modelling aims at improving the theoretical estimates of these decays, which are needed when no measurement is available. Allowed and forbidden unique transitions are calculated on the basis of precise relativistic wave functions of the atomic electrons, determined in previous work. In this context, correcting for atomic effects is of high importance. The two common approaches from Bahcall and Vatai to correct for the overlap and exchange effects have been extended to every subshell in a unified formulation, with the electron occupation precisely taken into account...
July 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28756907/universal-screening-for-alcohol-misuse-in-acute-medical-admissions-is-feasible-and-identifies-patients-at-high-risk-of-liver-disease
#7
Greta Westwood, Paul Meredith, Susan Atkins, Peter Greengross, Paul E Schmidt, Richard J Aspinall
BACKGROUND & AIMS: Many people who die from alcohol related liver disease (ARLD) have a history of recurrent admissions to hospital, representing potential missed opportunities for intervention. Universal screening for alcohol misuse has been advocated but it is not known if this is achievable or effective at detecting individuals at high risk of ARLD. METHODS: We systematically screened all admissions to the Acute Medical Unit (AMU) of a large acute hospital using an electronic data capture system in real time...
July 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28755819/descriptive-epidemiology-medical-evaluation-and-outcomes-of-rock-climbing-injuries
#8
James W McDonald, A Michael Henrie, Masaru Teramoto, Edward Medina, Stuart E Willick
OBJECTIVE: To gather epidemiologic data on injury type, treatment, and recovery from rock climbing injuries. METHODS: Design: retrospective cross-sectional study. SETTING: web-based survey. PARTICIPANTS: rock climbers who sustained a climbing-related injury during the prior 24 months. Criteria for inclusion: aged ≥18 years; participation in rock climbing at least 4 times per year in the United States. INTERVENTIONS: none...
July 26, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28755259/structural-characterization-of-a-thrombin-aptamer-complex-by-high-resolution-native-top-down-mass-spectrometry
#9
Jiang Zhang, Rachel R Ogorzalek Loo, Joseph A Loo
Native mass spectrometry (MS) with electrospray ionization (ESI) has evolved as an invaluable tool for the characterization of intact native proteins and non-covalently bound protein complexes. Here we report the structural characterization by high resolution native top-down MS of human thrombin and its complex with the Bock thrombin binding aptamer (TBA), a 15-nucleotide DNA with high specificity and affinity for thrombin. Accurate mass measurements revealed that the predominant form of native human α-thrombin contains a glycosylation mass of 2205 Da, corresponding to a sialylated symmetric biantennary oligosaccharide structure without fucosylation...
July 28, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28753734/negative-ions-molecular-electron-affinity-and-orbital-structure-of-cata-condensed-polycyclic-aromatic-hydrocarbons
#10
Rustem V Khatymov, Mars V Muftakhov, Pavel V Shchukin
RATIONALE: Polycyclic aromatic hydrocarbons are molecules of ecological, astrochemical significance, and find practical applications in organic electronics, photonics and the chemical synthesis of novel materials. The utility of these molecules often implies the occurrence of their ionized forms. Studies in the gas phase of elementary processes of energy-controlled interaction of molecules with low-energy electrons shed light on the mechanisms of transient negative ion formation and evolution...
July 28, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28752472/technical-challenges-related-to-implementation-of-a-formula-one-real-time-data-acquisition-and-analysis-system-in-a-paediatric-intensive-care-unit
#11
B Rajeswari Matam, Heather Duncan
Most existing, expert monitoring systems do not provide the real time continuous analysis of the monitored physiological data that is necessary to detect transient or combined vital sign indicators nor do they provide long term storage of the data for retrospective analyses. In this paper we examine the feasibility of implementing a long term data storage system which has the ability to incorporate real-time data analytics, the system design, report the main technical issues encountered, the solutions implemented and the statistics of the data recorded...
July 27, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28748883/epidemiology-and-outcome-of-tuberculosis-in-immunocompromised-patients
#12
Abdul Massiah Metry, Issa Al Salmi, Seif Al-Abri, Faisal Al Ismaili, Yaqoub Al Mahrouqi, Alan Hola, Faissal A M Shaheen
The United States Renal Data System showed 1.2% and 1.6% incidences of tuberculosis (TB) in patients on peritoneal dialysis and hemodialysis (HD), respectively. Kidney transplant (KTX) patients have higher rates. We studied the epidemiology and outcome of TB in patients with kidney dysfunction in a tertiary care hospital in the past decade. We examined data of patients with TB with and without kidney dysfunction from 2006 to 2015 through an electronic system. Statistical analysis was completed using Stata software, Chicago, IL, USA...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28744848/systems-and-precision-medicine-approaches-to-diabetes-heterogeneity-a-big-data-perspective
#13
Enrico Capobianco
Big Data, and in particular Electronic Health Records, provide the medical community with a great opportunity to analyze multiple pathological conditions at an unprecedented depth for many complex diseases, including diabetes. How can we infer on diabetes from large heterogeneous datasets? A possible solution is provided by invoking next-generation computational methods and data analytics tools within systems medicine approaches. By deciphering the multi-faceted complexity of biological systems, the potential of emerging diagnostic tools and therapeutic functions can be ultimately revealed...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28743191/successful-utilization-of-an-electronic-pain-diary-in-a-multinational-phase-3-interventional-study-of-pediatric-sickle-cell-anemia
#14
Lori E Heath, Matthew M Heeney, Carolyn C Hoppe, Samuel Adjei, Tsiri Agbenyega, Mohamed Badr, Nicoletta Masera, Chunmei Zhou, Patricia B Brown, Joseph A Jakubowski, Carlton Dampier
BACKGROUND/AIMS: Patients with sickle cell anemia can experience recurrent pain episodes, which affect quality of life. The reported prevalence of pain is higher in studies using patient diaries than in healthcare facility utilization data. Determining Effects of Platelet Inhibition on Vaso-Occlusive Events was a multinational study that assessed the efficacy and safety of prasugrel in reducing the rate of vaso-occlusive events in children with sickle cell anemia (NCT01794000) and included an electronic patient-reported outcome diary to record pain occurrence...
July 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28742789/evaluation-of-appropriate-venous-thromboembolism-prophylaxis-in-orthopaedic-trauma-patients-with-symptom-driven-vascular-and-radiographic-studies
#15
Christopher M Domes, Anneliese M Schleyer, James M McQueen, Ronald F Pergamit, Daphne M Beingessner
OBJECTIVE: To evaluate venous thromboembolism (VTE) prophylaxis adherence and effectiveness in orthopaedic trauma patients who had vascular or radiographic studies showing deep vein thromboses (DVTs) or pulmonary emboli (PEs). DESIGN: Retrospective review SETTING:: This study was conducted at a level I trauma center that independently services a 5 state region. The medical records of patients treated surgically between July 2010 and March 2013 were interrogated using a technical tool that electronically captures thrombotic event data from vascular and radiologic imaging studies via natural language processing...
July 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28739539/medication-reviews-bridging-healthcare-medbridge-study-protocol-for-a-pragmatic-cluster-randomised-crossover-trial
#16
Thomas G H Kempen, Maria Bertilsson, Karl-Johan Lindner, Johanna Sulku, Elisabet I Nielsen, Angelica Högberg, Tomas Vikerfors, Håkan Melhus, Ulrika Gillespie
BACKGROUND: Mismanaged prescribing and use of medication among elderly puts major pressure on current healthcare systems. Performing a medication review, a structured critical examination of a patient's medications, during hospital stay with active follow-up into primary care could optimise treatment benefit and minimise harm. However, a lack of high quality evidence inhibits widespread implementation. This manuscript describes the rationale and design of a pragmatic cluster-randomised, crossover trial to fulfil this need for evidence...
July 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28735107/integrative-modelling-of-cellular-assemblies
#17
REVIEW
Agnel Praveen Joseph, Guido Polles, Frank Alber, Maya Topf
A wide variety of experimental techniques can be used for understanding the precise molecular mechanisms underlying the activities of cellular assemblies. The inherent limitations of a single experimental technique often requires integration of data from complementary approaches to gain sufficient insights into the assembly structure and function. Here, we review popular computational approaches for integrative modelling of cellular assemblies, including protein complexes and genomic assemblies. We provide recent examples of integrative models generated for such assemblies by different experimental techniques, especially including data from 3D electron microscopy (3D-EM) and chromosome conformation capture experiments, respectively...
July 20, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28722399/bias-free-chemically-diverse-test-sets-from-machine-learning
#18
Ellen T Swann, Michael Fernandez, Michelle L Coote, Amanda S Barnard
Current benchmarking methods in quantum chemistry rely on databases that are built using a chemist's intuition. It is not fully understood how diverse or representative these databases truly are. Multivariate statistical techniques like archetypal analysis and K-means clustering have previously been used to summarize large sets of nanoparticles however molecules are more diverse and not as easily characterized by descriptors. In this work, we compare three sets of descriptors based on the one-, two-, and three-dimensional structure of a molecule...
July 27, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28708848/predicting-all-cause-risk-of-30-day-hospital-readmission-using-artificial-neural-networks
#19
Mehdi Jamei, Aleksandr Nisnevich, Everett Wetchler, Sylvia Sudat, Eric Liu
Avoidable hospital readmissions not only contribute to the high costs of healthcare in the US, but also have an impact on the quality of care for patients. Large scale adoption of Electronic Health Records (EHR) has created the opportunity to proactively identify patients with high risk of hospital readmission, and apply effective interventions to mitigate that risk. To that end, in the past, numerous machine-learning models have been employed to predict the risk of 30-day hospital readmission. However, the need for an accurate and real-time predictive model, suitable for hospital setting applications still exists...
2017: PloS One
https://www.readbyqxmd.com/read/28697045/patient-characteristics-menopause-symptoms-and-care-provided-at-an-interdisciplinary-menopause-clinic-retrospective-chart-review
#20
Beate C Sydora, Nese Yuksel, Nicole L Veltri, Justin Marillier, Christoph P Sydora, Maryna Yaskina, Lori Battochio, Tami M L Shandro, Sue Ross
OBJECTIVE: The goal of this study was to describe the characteristics, menopause symptoms, and treatment progressions in women cared for at an interdisciplinary menopause clinic. METHODS: We conducted a retrospective review of patient charts from women attending a multidisciplinary menopause clinic. Data collected from the charts included patient demographics, menopause symptoms, other concurrent medical conditions, and treatment recommendations. Data were entered into Research Electronic Data Capture database and analyzed descriptively...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
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