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Arnaud Machelart, Abir Khadrawi, Aurore Demars, Kevin Willemart, Carl De Trez, Jean-Jacques Letesson, Eric Muraille
The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209(+) MZ macrophages (MZMs) and the CD169(+) marginal metallophilic macrophages (MMMs). Acute systemic infection strongly impacts MZ populations and the location of T and B lymphocytes. This phenomenon has been linked to reduced chemokine secretion by stromal cells. Brucella spp. are the causative agent of brucellosis, a widespread zoonotic disease. Here, we used B...
August 14, 2017: Infection and Immunity
Banafsheh Soltani, Morteza Asghari
Polyurethane (PU)-ZnO mixed matrix membranes (MMM) were fabricated and characterized for gas separation. A thermogravimetric analysis (TGA), a scanning electron microscope (SEM) test and an atomic-force microscopy (AFM) revealed that the physical properties and thermal stability of the membranes were improved through filler loading. Hydrogen Bonding Index, obtained from the Fourier transform infrared spectroscopy (FTIR), demonstrate that the degree of phase separation in PU-ZnO 0.5 wt % MMM was more than the neat PU, while in PU-ZnO 1...
August 11, 2017: Membranes
Gunnar Jeschke
Structural characterization of proteins and their complexes may require integration of restraints from various experimental techniques. MMM is a Matlab-based open-source modelling toolbox for this purpose with a particular emphasis on distance distribution restraints obtained from electron paramagnetic resonance experiments on spin-labelled proteins and nucleic acids and their combination with atomistic structures of domains or whole protomers, small-angle scattering data, secondary structure information, homology information, and elastic network models...
August 11, 2017: Protein Science: a Publication of the Protein Society
Yasin Orooji, Feng Liang, Amir Razmjou, Sha Li, Mohammad Reza Mofid, Quan Liu, Kecheng Guan, ZhengKun Liu, Wanqin Jin
Flux and antifouling properties of mixed matrix membranes (MMM) are yet to attain satisfactory status. The aim of this study is to find a method for mitigating the biofouling of polyethersulfone (PES) ultrafiltration membranes via blending of thermoexfoliated vermiculite (VMT). Flow cytometry analysis shows that the behaviors of Bacillus subtilis 168 as a gram-positive bacterium and Escherichia coli DH5 alpha as a gram-negative bacterium were different. Hence, cell property is a suspected contributory factor in biofilm formation...
August 10, 2017: ACS Applied Materials & Interfaces
Silvia Capucci, Edmund G Wee, Torben Schiffner, Celia C LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J Klasse, Rogier W Sanders, John P Moore, Tomáš Hanke
Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. First, we showed that approximately two-thirds and one-third of the trimers secreted from the ChAdOx1...
2017: PloS One
Changchang Zou, Qianqian Li, Yinying Hua, Bihang Zhou, Jingui Duan, Wanqin Jin
Covalent organic framework (COF) membranes used to selective removal of CO2 was believed as an efficient and low-cost solution to energy and environmental sustainability. In this study, the amide modified COF nanosheet cluster with 2D structure was facilely prepared through solid reaction, exhibiting good adsorption-based CO2 selectivity (223 at 273K and 90 at 298K) towards N2. Remarkably, the mixed matrix membrane (MMM) that consist of less amount of COF filler (1wt%) shows promising CO2/N2 gas selectivity (64)...
August 9, 2017: ACS Applied Materials & Interfaces
Loreto Troncoso, María Celeste Gardey, María Teresa Fernández-Díaz, José Antonio Alonso
In the aim to stabilize novel three-dimensional perovskite oxides based upon SrCoO3-δ, we have designed and prepared SrCo1-xRexO3-δ phases (x = 0.05 and 0.10), successfully avoiding the competitive hexagonal 2H polytypes. Their performance as cathode materials in intermediate-temperature solid oxide fuel cells (IT-SOFC) has been investigated. The characterization of these oxides included X-ray (XRD) and in situ temperature-dependent neutron powder diffraction (NPD) experiments for x = 0.10. At room temperature, SrCo1-xRexO3-δ perovskites are defined in the P4/mmm space group, which corresponds to a subtle tetragonal perovskite superstructure with unit-cell parameters a = b ≈ ao, c = 2ao (ao = 3...
August 24, 2016: Materials
Hyeon-Gyu Choi, Moon Son, Heechul Choi
Thin-film composite mixed matrix membrane (TFC MMM) with functionalized carbon nanotube (fCNT) blended in polyethersulfone (PES) support layer was synthesized via interfacial polymerization and phase inversion. This membrane was firstly tested in lab-scale integrating seawater desalination and wastewater reclamation forward osmosis (FO) process. Water flux of TFC MMM was increased by 72% compared to that of TFC membrane due to enhanced hydrophilicity. Although TFC MMM showed lower water flux than TFC commercial membrane, enhanced reverse salt flux selectivity (RSFS) of TFC MMM was observed compared to TFC membrane (15% higher) and TFC commercial membrane (4% higher), representing membrane permselectivity...
October 2017: Chemosphere
Lisa M Clancy, Amy L Cooper, Gareth W Griffith, Roger D Santer
Same-sex sexual behaviour occurs across diverse animal taxa, but adaptive explanations can be difficult to determine. Here we investigate male-male mounting (MMM) behaviour in female-deprived desert locust males infected with the entomopathogenic fungus Metarhizium acridum. Over a four-week period, infected locusts performed more MMM behaviours than healthy controls. Among infected locusts, the probability of MMM, and the duration of time spent MMM, significantly increased with the mounting locust's proximity to death...
July 18, 2017: Scientific Reports
Torben Lund Skovhus, Richard B Eckert, Edgar Rodrigues
Microbiologically influenced corrosion (MIC) is the terminology applied where the actions of microorganisms influence the corrosion process. In literature, terms such as microbial corrosion, biocorrosion, microbially influenced/induced corrosion, and biodegradation are often applied. MIC research in the oil and gas industry has seen a revolution over the past decade, with the introduction of molecular microbiological methods: (MMM) as well as new industry standards and procedures of sampling biofilm and corrosion products from the process system...
July 4, 2017: Journal of Biotechnology
Yang Wang, Qi Wang, Yuan Li, Ying Chen, Jiari Shao, Nwankpa Nick, Chunyan Li, Jiuqing Xin
Mycoplasma mycoides subsp.mycoides (Mmm) is a pathogen that causes pneumonia, otitis media, and arthritis in young calves. Its pathogenesis is attributed in part to excessive immune responses. Mmm-derived lipid-associated membrane proteins (LAMPs) are potent inducers of the host innate immune system; however, interactions between Mmm-derived LAMPs as pathogenic agents, toll-like receptors (TLRs), and the signaling pathways responsible for activating inflammation and nuclear factor (NF)-κB have not been fully elucidated...
June 28, 2017: Scientific Reports
John V Seeley, Nicolaas E Schimmel, Stacy K Seeley
A fluidic device called the multi-mode modulator (MMM) has been developed for use as a comprehensive two-dimensional gas chromatography (GC x GC) modulator. The MMM can be employed in a wide range of capacities including as a traditional heart-cutting device, a low duty cycle GC x GC modulator, and a full transfer GC x GC modulator. The MMM is capable of producing narrow component pulses (widths <50ms) while operating at flows compatible with high resolution chromatography. The sample path of modulated components is confined to the interior of a joining capillary...
June 13, 2017: Journal of Chromatography. A
Yanchao Wang, Sheng Wang, Yunwei Zhang, Jian Lv, Yue Chen, Weitao Zheng, Yanming Ma
It has been widely believed that SrO2, a typical alkaline earth metal peroxide, should adopt the tetrahedral CaC2-type structure (space group I4/mmm) at ambient pressure. Here we report a monoclinic structure (space group C2c), as predicted from first-principles swarm structure searching simulations, is energetically more favorable than the CaC2-type structure at ambient pressure and low temperature, while the I4/mmm structure is only stable at high pressure (>20 GPa) or elevated temperature conditions. A key difference between these structures is the distinct orientation of peroxide ions...
June 9, 2017: Inorganic Chemistry
Lu-Lu Liu, Hui-Juan Sun, C Z Wang, Wen-Cai Lu
In this work, the crystal structures of YH3 and YH4 at high pressure (100-250 GPa) have been explored using a genetic algorithm combined with first-principles calculations. New structures of YH3 with space group symmetries of P21/m and I4/mmm were predicted. The electronic structures and the phonon dispersion properties of various YH3 and YH4 structures at different temperatures and pressures were investigated. Among YH3 phases, the P21/m structure of YH3 was found to have a relatively high superconducting transformation temperature T c of 19 K at 120 GPa, which is reduced to 9 K at 200 GPa...
August 16, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Rupan Preet Kaur, Ravinder Singh Sawhney, Derick Engles
The transport properties of beryllium doped anthracene molecular junction are investigated using density functional non-equillibrium Green's function method. The equilibrium conductance of anthracene Metal-molecule-Metal (MmM) junction increases by approximately 77% by adding beryllium impurity to it. The electronic transport characteristics under both zero bias as well as finite bias are explored of such molecular junction. We observe novel attributes such as molecular rectification and NDR behavior for the molecular junction under consideration...
May 26, 2017: Journal of Molecular Graphics & Modelling
Željka Pezer, Amanda G Chung, Robert C Karn, Christina M Laukaitis
The Androgen-binding protein (Abp) gene region of the mouse genome contains 64 genes, some encoding pheromones that influence assortative mating between mice from different subspecies. Using CNVnator and quantitative PCR, we explored copy number variation in this gene family in natural populations of Mus musculus domesticus (Mmd) and M. m. musculus (Mmm), two subspecies of house mice that form a narrow hybrid zone in Central Europe. We found that copy number variation in the center of the Abp gene region is very common in wild Mmd, primarily representing the presence/absence of the final duplications described for the mouse genome...
May 29, 2017: Genome Biology and Evolution
Chun Hai Wang, Brendan J Kennedy, André L Menezes de Oliveira, Julia Polt, Kevin Steven Knight
In this work we synthesized BaTaO2N and SrTaO2N using a two-step high-temperature solid-state reaction method and analysed the structural distortions, relative to the ideal cubic perovskite structure, according to group theory. From a complete distortion analysis/refinement using high-resolution neutron diffraction data in the temperature range 8 to 613 K, we identified tetragonal structures for BaTaO2N [P4/mmm (No. 123)] and SrTaO2N [I4/mcm (No. 140)]. In contrast to an anion-disordered cubic perovskite (Pm \overline{3}m No...
June 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Gnu Nam, Woongjin Choi, Junsu Lee, Seong-Ji Lim, Hongil Jo, Kang Min Ok, Kyunghan Ahn, Tae-Soo You
The Zintl phase solid-solution Ca11-xYbxSb10-yGez (0 ≤ x ≤ 9; 0 ≤ y ≤ 3; 0 ≤ z ≤ 3) system with the cationic/anionic multisubstitution has been synthesized by molten Sn metal flux and arc-melting methods. The crystal structure of the nine title compounds were characterized by both powder and single-crystal X-ray diffractions and adopted the Ho11Ge10-type structure with the tetragonal space group I4/mmm (Z = 4, Pearson Code tI84). The overall isotypic structure of the nine title compounds can be illustrated as an assembly of three different types of cationic polyhedra sharing faces with their neighboring polyhedra and the three-dimensional cage-shaped anionic frameworks consisting of the dumbbell-shaped Sb2 units and the square-shaped Sb4 or (Sb/Ge)4 units...
May 30, 2017: Inorganic Chemistry
M Gutiérrez, M López-González, F Sánchez, A Douhal
Light harvesting is a natural phenomenon that scientists try to mimic in artificial systems. Having this in mind, attention has been focused on using new smart-materials for photonics. Herein, we report on the photobehaviour of a Zr-NDC MOF (NDC = dimethyl 2,6-naphthalenedicarboxylate) and its composite material, Coumarin153@Zr-NDC, embedded within a polymeric membrane of poly[bisphenol A carbonate-co-4,4'-(3,3,5-trimethylcyclohexylidene)diphenol carbonate] (PC). For the mixed matrix membrane (MMM) Zr-NDC/PC, we observed interparticle excimer-like formation, taking place in times shorter than 15 ps and giving rise to a red-shifted broad emission band...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
Nudrat Tasneem, Edgar A Samaniego, Connie Pieper, Enrique C Leira, Harold P Adams, David Hasan, Santiago Ortega-Gutierrez
Neurocritical care patients are at risk of developing secondary brain injury from inflammation, ischemia, and edema that follows the primary insult. Recognizing clinical deterioration due to secondary injury is frequently challenging in comatose patients. Multimodality monitoring (MMM) encompasses various tools to monitor cerebral metabolism, perfusion, and oxygenation aimed at detecting these changes to help modify therapies before irreversible injury sets in. These tools include intracranial pressure (ICP) monitors, transcranial Doppler (TCD), Hemedex™ (thermal diffusion probe used to measure regional cerebral blood flow), microdialysis catheter (used to measure cerebral metabolism), Licox™ (probe used to measure regional brain tissue oxygen tension), and continuous electroencephalography...
2017: Critical Care Research and Practice
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