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https://www.readbyqxmd.com/read/28922455/stem-cell-mobilization-in-patients-with-dialysis-dependent-multiple-myeloma-report-of-the-polish-multiple-myeloma-group
#1
Anna Waszczuk-Gajda, Joanna Drozd-Sokołowska, Piotr Boguradzki, Jarosław Dybko, Tomasz Wróbel, Grzegorz Władysław Basak, Krzysztof Mądry, Emilian Snarski, Grzegorz Charliński, Ewa Frączak, Joanna Matuszkiewicz-Rowińska, Marian Klinger, Hanna Augustyniak-Bartosik, Magdalena Krajewska, Paweł Żebrowski, Maria Król, Elżbieta Urbanowska, Artur Jurczyszyn, Michał Taszner, Wieslaw Wiktor Jędrzejczak, Jadwiga Dwilewicz-Trojaczek
INTRODUCTION: High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) improves the outcome of patients with multiple myeloma (MM). It seems that auto-HSCT is also a feasible therapeutic option in MM dialysis-dependent (MMDD) patients. However, to perform transplantation, a sufficient number of stem cells must be collected. MATERIALS AND METHODS: Given that data on mobilization of auto-HSC efficacy and safety in dialysis-dependent patients are limited, we report data from all Polish Centers belonging to the Polish Multiple Myeloma Group...
September 18, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28922415/rewiring-monocyte-glucose-metabolism-via-c-type-lectin-signaling-protects-against-disseminated-candidiasis
#2
Jorge Domínguez-Andrés, Rob J W Arts, Rob Ter Horst, Mark S Gresnigt, Sanne P Smeekens, Jacqueline M Ratter, Ekta Lachmandas, Lily Boutens, Frank L van de Veerdonk, Leo A B Joosten, Richard A Notebaart, Carlos Ardavín, Mihai G Netea
Monocytes are innate immune cells that play a pivotal role in antifungal immunity, but little is known regarding the cellular metabolic events that regulate their function during infection. Using complementary transcriptomic and immunological studies in human primary monocytes, we show that activation of monocytes by Candida albicans yeast and hyphae was accompanied by metabolic rewiring induced through C-type lectin-signaling pathways. We describe that the innate immune responses against Candida yeast are energy-demanding processes that lead to the mobilization of intracellular metabolite pools and require induction of glucose metabolism, oxidative phosphorylation and glutaminolysis, while responses to hyphae primarily rely on glycolysis...
September 18, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28922132/design-of-secure-and-lightweight-authentication-protocol-for-wearable-devices-environment
#3
Ashok Kumar Das, Mohammad Wazid, Neeraj Kumar, Muhammad Khurram Khan, Kim-Kwang Raymond Choo, YoungHo Park
Wearable devices are used in various applications to collect information including step information, sleeping cycles, workout statistics, and health related information. Due to the nature and richness of the data collected by such devices, it is important to ensure the security of the collected data. This paper presents a new lightweight authentication scheme suitable for wearable device deployment. The scheme allows a user to mutually authenticate his/her wearable device(s) and the mobile terminal (e.g., Android and iOS device) and establish a session key among these devices (worn and carried by the same user) for secure communication between the wearable device and the mobile terminal...
September 18, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28918874/the-outcome-of-intracapsular-hip-fracture-fixation-using-the-targon-femoral-neck-tfn-locking-plate-system-or-cannulated-cancellous-screws-a-comparative-study-involving-2004-patients
#4
Zeiad Alshameeri, Mohamed Elbashir, Martyn J Parker
AIM: This study compares the outcome of intracapsular hip fracture fixation using the Targon Femoral Neck (TFN) locking plate system with the standard fixation using cannulated cancellous screws (CCS). PATIENTS AND METHOD: Analyses of a prospectively collected data of all patients treated for intracapsular hip fractures using the TFN system and CCS at our department over a period of 28 years. Baseline characteristics and specific outcome measures where compared...
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28915431/ethical-implications-of-location-and-accelerometer-measurement-in-health-research-studies-with-mobile-sensing-devices
#5
Daniel Fuller, Martine Shareck, Kevin Stanley
Quantification of individual behaviours using mobile sensing devices, including physical activity and spatial location, is a rapidly growing field in both academic research and the corporate world. In this case study, we summarize the literature examining the ethical aspects of mobile sensing and argue that a robust discussion about the ethical implications of mobile sensing for research purposes has not occurred sufficiently in the literature. Based on our literature summary and guided by basic ethical principles set out in Canadian, US, and International Ethics documents we propose four areas where further discussion should occur: consent, privacy and confidentiality, mitigating risk, and consideration of vulnerable populations...
September 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28914720/effects-of-corrective-exercise-for-thoracic-hyperkyphosis-on-posture-balance-and-well-being-in-older-women-a-double-blind-group-matched-design
#6
Hyun-Jeong Jang, Lynne C Hughes, Duck-Won Oh, Suhn-Yeop Kim
BACKGROUND AND PURPOSE: The purpose of this study was to identify the effects of a corrective exercise for thoracic hyperkyphosis on posture, balance, and well-being in Korean community-dwelling older women. METHODS: Fifty women 65 years of age and older, recruited from 2 senior centers, participated in this study. Participants were assigned to either the experimental group (EG) or the control group (CG) on the basis of convenience of location, and 22 in each were analyzed...
September 13, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28912114/understanding-the-natural-progression-of-spina-bifida-prospective-study
#7
Judy Thibadeau, Matthew R Reeder, Jennifer Andrews, Katherine Ong, Marcia L Feldkamp, Sydney Rice, Ann Alriksson-Schmidt
BACKGROUND: Spina bifida (SB) is monitored through birth defects surveillance across the United States and in most developed countries. Although much is known about the management of SB and its many comorbid conditions in affected individuals, there are few systematic, longitudinal studies on population-based cohorts of children or adults. The natural history of SB across the life course of persons with this condition is not well documented. Earlier identification of comorbidities and secondary conditions could allow for earlier intervention that might enhance the developmental trajectory for children with SB...
September 14, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28904728/evaluation-of-the-acute-flaccid-paralysis-afp-surveillance-system-gokwe-north-district-zimbabwe-2015-a-descriptive-cross-sectional-study
#8
Annamercy Makoni, Milton Chemhuru, Notion Gombe, Gerald Shambira, Tsitsi Juru, Donewell Bangure, Mufuta Tshimanga
INTRODUCTION: AFP surveillance was adopted globally as a key strategy for monitoring the progress of the polio eradication initiative. Gokwe North district with an estimated 119 655 children <15 years detected 2 cases, 4 cases and 1 case of AFP in 2012, 2013 and 2014 respectively against a target of 5 cases per year. We therefore set out to evaluate the system and find out why it was failing to detect at least 5 cases per year. METHODS: A descriptive cross sectional study was carried out...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28901247/effect-on-morphology-osmotic-fragility-and-electro-kinetic-potential-of-erythrocytes-in-hypertension
#9
Swati Sanjay Gaikwad, J G Avari
BACKGROUND: Hypertension is a common health problem concerning a large proportion of population and a leading global risk factor for the burden of cardiovascular disease (CVD). The purpose of this study was to assess the efficacy of the erythrocyte zeta potential as a potential additional indicator for cardiovascular disorder risk so that patients with this can be more rapidly identified and treated. METHODS: In the present study, blood samples were collected in 5% dextrose solution from patients suffering from hypertension and healthy volunteers (Not taken any medication)...
September 11, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28900737/the-benefit-of-the-systematic-revision-of-the-acetabular-implant-in-favor-of-a-dual-mobility-articulation-during-the-treatment-of-periprosthetic-fractures-of-the-femur-a-49-cases-prospective-comparative-study
#10
A Perrin, M Saab, S Putman, K Benad, E Drumez, C Chantelot
INTRODUCTION: The SOFCOT symposium (2005) on periprosthetic fractures of the femur (PFFs) highlighted a high rate of dislocation (15.6% at 6 months) after change of prosthesis. So far, no study has ever proved the benefit of dual-mobility articulation during PFFs revisions. We conducted a comparative study on two prospective cohorts in order to (1) assess the influence of systematic acetabular revision in favor of a double mobility on dislocation rate (2) and in order to evaluate the rate of morbidity associated with this extra surgical procedure...
September 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28899374/determinants-of-internal-migrant-health-and-the-healthy-migrant-effect-in-south-india-a-mixed-methods-study
#11
Warren Dodd, Sally Humphries, Kirit Patel, Shannon Majowicz, Matthew Little, Cate Dewey
BACKGROUND: Internal labour migration is an important and necessary livelihood strategy for millions of individuals and households in India. However, the precarious position of migrant workers within Indian society may have consequences for the health of these individuals. Previous research on the connections between health and labour mobility within India have primarily focused on the negative health outcomes associated with this practice. Thus, there is a need to better identify the determinants of internal migrant health and how these determinants shape migrant health outcomes...
September 12, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28898529/the-design-development-and-evaluation-of-a-qualitative-data-collection-application-for-pregnant-women
#12
Hazel Keedle, Virginia Schmied, Elaine Burns, Hannah Dahlen
PURPOSE: This article explores the development and evaluation of a smartphone mobile software application (app) to collect qualitative data. The app was specifically designed to capture real-time qualitative data from women planning a vaginal birth after caesarean delivery. This article outlines the design and development of the app to include funding, ethics, and the recruitment of an app developer, as well as the evaluation of using the app by seven participants. ORGANIZING CONSTRUCT: Data collection methods used in qualitative research include interviews and focus groups (either online, face-to-face, or by phone), participant diaries, or observations of interactions...
September 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28895029/chemical-characteristics-of-soluble-aerosols-over-the-central-himalayas-insights-into-spatiotemporal-variations-and-sources
#13
Lekhendra Tripathee, Shichang Kang, Dipesh Rupakheti, Zhiyuan Cong, Qianggong Zhang, Jie Huang
In order to investigate the spatial and temporal variations of aerosols and its soluble chemical compositions of the data gap zone in the central Himalayan region, aerosol samples were collected at four sites. The sampling location were characterized by four different categories, such as urban (Bode), semi-urban site in the northern Indo-Gangetic Plain (Lumbini), rural (Dhunche), and semiarid rural (Jomsom). A total of 230 aerosol samples were collected from four representative sites for a yearlong period and analyzed for water-soluble inorganic ions (WSIIs)...
September 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28894746/behavioral-health-characteristics-of-a-technology-enabled-sample-of-alzheimer-s-caregivers-with-high-caregiver-burden
#14
Ian Coffman, Helaine E Resnick, Corinna E Lathan
BACKGROUND: Caregivers of persons with dementia/Alzheimer's disease (AD) experience considerable physical and psychological burdens associated with their caregiving role. Although mobile technologies have the potential to deliver caregiver supports, it is necessary to demonstrate that caregivers in need of these supports are technology-enabled, that they can be identified and accessed, and that they experience the same unfavorable mental health outcomes characteristic of the broader caregiving population...
2017: MHealth
https://www.readbyqxmd.com/read/28893710/user-preferences-for-mobile-health-interventions-a-survey-among-intermittent-claudication-patients-and-their-physical-therapists
#15
Marijn Ml van den Houten, Steffie Spruijt, Hugo Jp Fokkenrood, Marc Rm Scheltinga, Joep Aw Teijink
OBJECTIVES: Smartphone apps provide novel ways of triggering lifestyle-change by coupling objective measurements of health behavior with tailored feedback. Little is known about end-user preferences regarding the content of mobile health (mHealth) interventions. The aim of this study was to assess smartphone use and preferences regarding app-content among intermittent claudication patients and their treating physical therapists. METHODS: A cross-sectional survey was sent via an internal email system to 1514 physical therapists specialized in treating patients with intermittent claudication...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28893264/maximizing-research-study-effectiveness-in-malaria-elimination-settings-a-mixed-methods-study-to-capture-the-experiences-of-field-based-staff
#16
Sara E Canavati, Cesia E Quintero, Britt Haller, Dysoley Lek, Sovann Yok, Jack S Richards, Maxine Anne Whittaker
BACKGROUND: In a drug-resistant, malaria elimination setting like Western Cambodia, field research is essential for the development of novel anti-malarial regimens and the public health solutions necessary to monitor the spread of resistance and eliminate infection. Such field studies often face a variety of similar implementation challenges, but these are rarely captured in a systematic way or used to optimize future study designs that might overcome similar challenges. Field-based research staff often have extensive experience and can provide valuable insight regarding these issues, but their perspectives and experiences are rarely documented and seldom integrated into future research protocols...
September 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28893012/pattern-of-self-prescribed-analgesic-use-in-a-rural-area-of-delhi-exploring-the-potential-role-of-internet
#17
Anjali Kochhar, Tanya Gupta
INTRODUCTION: Analgesics are the most common self prescribed drugs. Although considered to be relatively safe, side effects are often seen when these drugs are used for prolonged period, in high doses or used where contraindicated. Majority of the consumers are not aware of the side effects. These days ample amount of information is available on web, it is important to explore its role in educating the population regarding the safe use of self prescribed analgesics. AIM: To explore pattern of analgesic use, to identify population at risk of developing side effects related to analgesic use, awareness of side effects and potential role of internet to bring awareness about safe use of self prescribed analgesic drugs in a rural area of Delhi...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28885942/motivations-for-weight-loss-among-active-duty-military-personnel
#18
Courtney Maclin-Akinyemi, Rebecca A Krukowski, Mehmet Kocak, G Wayne Talcott, Alexis Beauvais, Robert C Klesges
INTRODUCTION: Rates of overweight and obesity among Active Duty Military Personnel remain high despite fitness test requirements, negative consequences of fitness test failure, and emphasis on weight and appearance standards. Specific motivating factors for weight loss influence weight loss program interest and often differ by gender, race, ethnicity, or age. This study investigates the weight loss motivations endorsed by a diverse population of Active Duty Military Personnel initiating a behavioral weight loss study, to inform the development of future recruitment efforts and program development...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885560/a-novel-energy-efficient-approach-for-human-activity-recognition
#19
Lingxiang Zheng, Dihong Wu, Xiaoyang Ruan, Shaolin Weng, Ao Peng, Biyu Tang, Hai Lu, Haibin Shi, Huiru Zheng
In this paper, we propose a novel energy-efficient approach for mobile activity recognition system (ARS) to detect human activities. The proposed energy-efficient ARS, using low sampling rates, can achieve high recognition accuracy and low energy consumption. A novel classifier that integrates hierarchical support vector machine and context-based classification (HSVMCC) is presented to achieve a high accuracy of activity recognition when the sampling rate is less than the activity frequency, i.e., the Nyquist sampling theorem is not satisfied...
September 8, 2017: Sensors
https://www.readbyqxmd.com/read/28884875/successful-collection-of-peripheral-blood-stem-cells-upon-vide-chemomobilization-in-sarcoma-patients
#20
Katharina Kriegsmann, Christoph Heilig, Martin Cremer, Philipp Novotny, Mark Kriegsmann, Thomas Bruckner, Carsten Müller-Tidow, Gerlinde Egerer, Patrick Wuchter
OBJECTIVES: In patients with Ewing sarcoma and some distinct subgroups of soft tissue sarcoma (STS), a quantitatively sufficient autologous peripheral blood stem cell (PBSC) collection for stem cell support might facilitate treatment continuation, dose-intensification and high-dose chemotherapy. Here we provide a detailed evaluation of PBSC collection upon vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) chemomobilization. METHODS: Mobilization and collection parameters of 42 sarcoma patients (Ewing sarcoma n=35, other STS n=7) were analyzed retrospectively...
September 8, 2017: European Journal of Haematology
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