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https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#1
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29730659/myxedema-coma-due-to-hashimoto-thyroiditis-a-rare-but-real-presentation-of-failure-to-thrive-in-infancy
#2
Ryan A Heksch, Rohan K Henry
BACKGROUND: Hashimoto thyroiditis (HT) is uncommon in infancy, and myxedema coma (MC) is even less common. While prior reports have documented these entities separately, to our knowledge, MC in combination with HT has not been reported before in this age group. METHODS/RESULTS: A 10-month-old female presented with ptosis, lethargy, dysphagia, and failure to thrive (FTT). She developed hypotension, bradycardia, hypothermia, and apnea requiring intubation. Initial thyroid-stimulating hormone was 422 μIU/mL, and free thyroxine was < 0...
May 4, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29729156/correlations-between-lipid-metabolism-indices-in-patients-with-hypertension-and-hypothyroidism
#3
Lyubov V Olenych, Lesya I Pylypiv, Nataliya S Bek, Olena M Radchenko
OBJECTIVE: Introduction: Hypertension is a major reason behind morbidity, disability and mortality. Elevated blood pressure is a huge risk factor for cardio-vascular diseases. Almost 90% of hypertension patients have internal comorbidities, in particular hypothyroidism. For now, however, the specificities of the clinical course of hypertension in hypothyroid patients are understudied and the data on lipid metabolism in patients with primary hypothyroidism and hypertension are inconclusive...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29695647/a-case-of-tsh-secreting-pituitary-adenoma-with-cyclic-fluctuations-in-serum-tsh-levels
#4
Hideyuki Okuma, Koshi Hashimoto, Takuya Ohashi, Masatomo Mihara, Isao Minami, Hajime Izumiyama, Shigekazu Sasaki, Naoko Inoshita, Hiroshi Nishioka, Shozo Yamada, Takanobu Yoshimoto
A 29-year-old man was referred to our department due to adrenal insufficiency with the inappropriate secretion of TSH (SITSH). Magnetic resonance imaging revealed a pituitary tumor. A weak TSH response in the TRH test, elevated sex hormone binding globulin (SHBG) levels, and the absence of a family medical history of SITSH or TRβ gene mutations supported the diagnosis of TSH-secreting pituitary adenoma (TSHoma). However, complete TSH suppression and a blunted cholesterol response in the T3 suppression test as well as normal glycoprotein α-subunit (α-GSU) levels were not compatible with TSHoma...
April 26, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29682594/the-role-of-leptin-in-maintaining-plasma-glucose-during-starvation
#5
Rachel J Perry, Gerald I Shulman
For 20 years it has been known that concentrations of leptin, a hormone produced by the white adipose tissue (WAT) largely in proportion to body fat, drops precipitously with starvation, particularly in lean humans and animals. The role of leptin to suppress the thyroid and reproductive axes during a prolonged fast has been well defined; however, the impact of leptin on metabolic regulation has been incompletely understood. However emerging evidence suggests that, in starvation, hypoleptinemia increases activity of the hypothalamic-pituitary-adrenal axis, promoting WAT lipolysis, increasing hepatic acetyl-CoA concentrations, and maintaining euglycemia...
March 2018: Postdoc Journal
https://www.readbyqxmd.com/read/29663312/mortality-in-patients-with-permanent-hypoparathyroidism-after-total-thyroidectomy
#6
M Almquist, K Ivarsson, E Nordenström, A Bergenfelz
BACKGROUND: Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long-term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. METHODS: Data from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery were linked with the Swedish National Prescription Register for Pharmaceuticals and the Swedish National Inpatient Register...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29661472/news-about-the-genetics-of-congenital-primary-adrenal-insufficiency
#7
Florence Roucher-Boulez, Delphine Mallet-Motak, Véronique Tardy-Guidollet, Rita Menassa, Claire Goursaud, Ingrid Plotton, Yves Morel
Primary adrenal insufficiency (PAI) is characterized by impaired production of steroid hormones due to an adrenal cortex defect. This condition incurs a risk of acute insufficiency which may be life-threatening. Today, 80% of pediatric forms of PAI have a genetic origin but 5% have no clear genetic support. Recently discovered mutations in genes relating to oxidative stress have opened the way to research on genes unrelated to the adrenal gland. Identification of causal mutations in a gene responsible for PAI allows genetic counseling, guidance of follow-up and prevention of complications...
April 13, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29577261/clock-genes-alterations-and-endocrine-disorders
#8
REVIEW
Anna Angelousi, Eva Kassi, Narjes Nasiri-Ansari, Martin O Weickert, Harpal Randeva, Gregory Kaltsas
BACKGROUND: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock. DESIGN: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. RESULTS: Various human single nucleotide polymorphisms of BMAL1 and CLOCK genes exhibited significant associations with type 2 diabetes mellitus...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29563068/pediatric-endocrine-and-metabolic-diseases-and-proteomics
#9
Ioanna Kosteria, Christina Kanaka-Gantenbein, Athanasios K Anagnostopoulos, George P Chrousos, George Th Tsangaris
The principles of Predictive, Preventive and Personalized Medicine (PPPM) dictate the need to recognize individual susceptibility to disease in a timely fashion and to offer targeted preventive interventions and treatments. Proteomics is a state-of-the art technology- driven science aiming at expanding our understanding of the pathophysiologic mechanisms that underlie disease, but also at identifying accurate predictive, diagnostic and therapeutic biomarkers, that will eventually promote the implementation of PPPM...
March 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29549931/impairment-of-thyroid-function-in-critically-ill-patients-in-the-intensive-care-units
#10
Eashaa Kumar, Michael T McCurdy, Christian A Koch, Abdurrahman Hamadah, Tibor Fülöp, Kamel A Gharaibeh
Unexplained hypotension in the intensive care unit is commonly attributed to volume depletion, cardiorespiratory failure, sepsis, or relative adrenal insufficiency. In these acute conditions, thyroid hormone levels measured in blood, serum or plasma are often altered and solely attributed to critical illness. We report a series of 3 critically ill patients with prolonged respiratory failure, suppressed mental status and unexplained hypotension. Thyroid stimulating hormone levels ranged from normal to mildly elevated (2...
March 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29545373/hormonally-mediated-effects-of-artificial-light-at-night-on-behavior-and-fitness-linking-endocrine-mechanisms-with-function
#11
REVIEW
Jenny Q Ouyang, Scott Davies, Davide Dominoni
Alternation between day and night is a predictable environmental fluctuation that organisms use to time their activities. Since the invention of artificial lighting, this predictability has been disrupted and continues to change in a unidirectional fashion with increasing urbanization. As hormones mediate individual responses to changing environments, endocrine systems might be one of the first systems affected, as well as being the first line of defense to ameliorate any negative health impacts. In this Review, we first highlight how light can influence endocrine function in vertebrates...
March 15, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29541701/does-tsh-reliably-detect-hypothyroid-patients
#12
C Ling, Q Sun, J Khang, M Felipa Lastarria, J Strong, B Stolze, X Yu, T P Parikh, M A Waldman, K Welsh, J Jonklaas, L Masika, S J Soldin
Objectives: To evaluate the reliability of normal Thyroid Stimulating Hormone (TSH) as a thyroid function test and assess the effect of Adrenocorticotropic Hormone (ACTH) on serum TSH concentration. Design and Methods: Patients presenting to the National Institutes of Health Department of Endocrinology outpatient clinic with symptoms consistent with hypothyroidism were identified. Thyroid hormone concentrations were measured by liquid chromatography/tandem mass spectrometry and immunoassay...
2018: Annals of Thyroid Research
https://www.readbyqxmd.com/read/29518865/-clinical-characteristics-of-central-diabetes-insipidus-a-retrospective-analysis-of-230-cases
#13
J P Zhang, Q H Guo, Y M Mu, Z H Lyu, W J Gu, G Q Yang, J Du, J M Ba, J M Lu
Objective: To evaluate the clinical characteristics and etiologies of central diabetes insipidus (CDI). Methods: The clinical data of 230 patients with CDI in the Department of Endocrinology of Chinese PLA General Hospital from 2008 June to 2014 December were collected and analyzed retrospectively. Results: The three most common causes of CDI were idiopathic CDI, lymphocytic hypophysitis and intracranial germ cell tumors. Among all the CDI, the idiopathic CDI accounted for 37.48%. There were significant differences in age onset and gender distribution among the different causes of CDI...
March 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29518754/endocrine-sequelae-of-immune-checkpoint-inhibitors
#14
REVIEW
Georgia Ntali, Eva Kassi, Maria Alevizaki
Cancer immunotherapy has introduced a novel class of drugs known as immune checkpoint inhibitors (ICIs). They enhance antitumour immunity by blocking negative regulators (checkpoints) of T cell function that exist on both immune and tumour cells. ICIs targeting CTLA-4 and PD-1/PDL-1 have dramatically changed the outcome of patients with several advanced-stage malignancies but they may lead to a variety of inflammatory toxicities and autoimmune consequences. The main endocrine immune-related adverse events (IRAEs) include hypophysitis, primary thyroid dysfunction, adrenalitis and type 1 diabetes mellitus...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29517680/an-ovarian-leydig-cell-tumor-of-ultrasound-negative-in-a-postmenopausal-woman-with-hirsutism-and-hyperandrogenism-a-case-report
#15
Min Chen, Weibin Zhou, Zhe Zhang, Yuting Zou, Chengjiang Li
RATIONALE: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. PATIENT CONCERNS: A 60-year-old woman, presented with increased hair growth and androgenic alopecia and the hormonal laboratory examination showed that she had elevated serum testosterone level and normal dehydroepiandrosterone sulfate (DHEAS), androstenedione, 17- hydroxyprogesterone, cortisol and thyroid stimulating hormone (TSH)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29504346/myxedema-coma
#16
Atif Munir
Myxedema may be the first presentation of patients with undiagnosed hypothyroidism. Definitive management is with thyroid hormone but supportive measures, identification and treatment of precipitating factors in an appropriately safe environment are vital. There is no consensus about preferred thyroid hormone regimen. Corticosteroid therapy is given until adrenal insufficiency has been excluded. We present here a case of seventy-four years old woman of myxodema coma.
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29502560/over-the-counter-adrenal-support-supplements-contain-thyroid-and-steroid-based-adrenal-hormones
#17
Halis Kaan Akturk, Ana Maria Chindris, Jolaine M Hines, Ravinder J Singh, Victor J Bernet
OBJECTIVE: To assess whether dietary supplements that are herbal and/or animal-derived products, marketed for enhancing metabolism or promoting energy, "adrenal fatigue," or "adrenal support," contain thyroid or steroid hormones. METHODS: Twelve dietary adrenal support supplements were purchased. Pregnenolone, androstenedione, 17-hydroxyprogesterone, cortisol, cortisone, dehydroepiandrosterone sulfate, synthetic glucocorticoids (betamethasone, dexamethasone, fludrocortisone, megestrol acetate, methylprednisolone, prednisolone, prednisone, budesonide, and triamcinolone acetonide) levels were measured twice in samples in a blinded fashion...
March 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29498364/elevated-serum-rantes-chemokine-levels-in-autoimmune-addison-disease
#18
Marta Fichna, Magdalena Żurawek, Bartłomiej Budny, Hanna Komarowska, Elżbieta Niechciał, Piotr Fichna, Marek Ruchała
INTRODUCTION    Regulated on activation, normal T‑cell expressed and secreted chemokine (RANTES), the product of the CCL5 gene, is involved in trafficking immune cells into the inflammation site. It acts as coactivator of T cells and promotes polarization of the immune response towards the Th1 profile. In autoimmune Addison disease (AAD), the adrenal cortex is gradually destroyed by adrenal‑specific immune cell infiltration. RANTES might be implicated in autoimmune adrenal failure through recruitment and activation of the immune cells...
April 30, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29495350/the-role-of-insulin-resistance-hyperinsulinism-on-the-rising-trend-of-thyroid-and-adrenal-nodular-disease-in-the-current-environment
#19
REVIEW
Agathocles Tsatsoulis
Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules, under the influence of growth stimulatory factors. Among the main stimulatory factors are the pituitary tropic hormones, thyroid-stimulating hormone (TSH) or thyrotropin and adrenocorticotropic hormone (ACTH), which regulate the growth and function of their respective target cells, and the insulin/insulin-like growth factor system, that, through its mitogenic effects, can stimulate the proliferation of these cells...
February 26, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29478039/the-natural-history-of-autoimmune-addison-s-disease-with-a-non-classical-presentation-a-case-report-and-review-of-literature
#20
REVIEW
Jacopo Manso, Raffaele Pezzani, Riccardo Scarpa, Nicoletta Gallo, Corrado Betterle
Autoimmune Addison's disease (AAD) is the most frequent cause of adrenocortical insufficiency. The natural history of AAD usually comprises five consecutive stages with the first stage characterized by the increase of plasma renin consistent with the impairment of pars glomerulosa, which is usually the first affected layer of the adrenal cortex. We describe a 19-year-old female with Hashimoto's thyroiditis (HT) who underwent an autoantibody screening due to having the personal and family history of other autoimmune diseases in the absence of relevant clinical manifestations...
May 24, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
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