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https://www.readbyqxmd.com/read/28214267/a-japanese-male-with-a-novel-ano5-mutation-with-minimal-muscle-weakness-and-muscle-pain-till-his-late-fifties
#1
Masato Kadoya, Katsuhisa Ogata, Mikiya Suzuki, Yutaka Honma, Kazunari Momma, Kana Yatabe, Takuhisa Tamura, Kenichi Kaida, Naomasa Miyata, Ichizo Nishino, Ikuya Nonaka, Mitsuru Kawai
Limb girdle muscular dystrophy type 2L (LGMD2L) is an adult-onset slowly progressive muscular dystrophy associated with anoctamin 5 (ANO5) gene mutation, mainly reported from Northern and Central Europe. We report the case of a Japanese male patient with a novel homozygous mutation of c.2394dup, p.Arg799Thrfs in ANO5 gene, the second patient in the Asian population. He had had marked elevation of creatine kinase (CK) level for more than 10 years with minimal muscular symptoms consisting of muscle stiffness and occasional cramps, preceding the onset of proximal limb weakness...
January 18, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28205467/a-rare-type-of-upper-extremity-injury-penetrating-injuries-caused-by-blunt-edged-items
#2
Hakan Şirinoğlu, Furkan Certel, Nebil Yeşïloğlu, Gökhan Temïz, Kübra Ece Kalafatlar, Murat Sarici, Özhan Çelebïler
BACKGROUND: Penetrating upper extremity injury is a common encountered cause of significant loss of labor force and it is generally caused by sharp items. This article presents five rare cases of penetrating hand and forearm injury caused by blunt-edged items in conjunction with a detailed discussion of the mechanism and management of the injury. METHODS: Five patients with a mean age of 37.6 were treated for upper extremity trauma caused by "blunt-edged items" such as corrugated iron fence, garden wires, iron stick or iron safety fence between 2009 to 2014...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28203021/-comparision-for-clinical-efficiency-of-continuous-adductor-canal-block-and-femoral-nerve-block-in-total-knee-arthroplasty
#3
M W Zhao, N Wang, L Zeng, M Li, Z K Zhao, H Zhang, H Tian
OBJECTIVE: To compare the pain control efficiency of continuous adductor canal block (ACB) and femoral nerve block (FNB) in total knee arthroplasty. METHODS: From April to September 2016, patients with severe knee osteoarthritis undergoing primary unilateral total knee arthroplasty (TKA) were prospectively observed, and all the patients were randomized received ultrasound-guided continuous ACB or FNB after surgery. Numeric pain rating scales(NPRS)pain scores in rest and activity 2, 6, 12, 24 and 48 h after surgery were collected, and the preoperative and postoperative quadriceps strength at 24 and 48 h were analyzed...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28198913/body-composition-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#4
Ivi Ribeiro Back, Sonia Silva Marcon, Natalia Moreno Gaino, Daniela Salate Biagioni Vulcano, Mariana de Souza Dorna, Ligia Yukie Sassaki
BACKGROUND: The nutritional status of individuals with inflammatory bowel diseases is directly related to the severity of the disease and is associated with poor prognosis and the deterioration of immune competence. OBJECTIVE: To assess the nutritional status and the body composition of outpatients with inflammatory bowel diseases. METHODS: A cross-sectional study was conducted with clinical and nutritional assessment of patients with Crohn's disease and ulcerative colitis...
February 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28186656/phenotype-and-genotype-specific-structural-alterations-in-spasmodic-dysphonia
#5
Serena Bianchi, Giovanni Battistella, Hailey Huddleston, Rebecca Scharf, Lazar Fleysher, Anna F Rumbach, Steven J Frucht, Andrew Blitzer, Laurie J Ozelius, Kristina Simonyan
BACKGROUND: Spasmodic dysphonia is a focal dystonia characterized by involuntary spasms in the laryngeal muscles that occur selectively during speaking. Although hereditary trends have been reported in up to 16% of patients, the causative etiology of spasmodic dysphonia is unclear, and the influences of various phenotypes and genotypes on disorder pathophysiology are poorly understood. In this study, we examined structural alterations in cortical gray matter and white matter integrity in relationship to different phenotypes and putative genotypes of spasmodic dysphonia to elucidate the structural component of its complex pathophysiology...
February 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28183279/three-dimensional-comparison-of-intramuscular-fat-content-between-young-and-old-adults
#6
Akito Yoshiko, Maya Hioki, Nana Kanehira, Kiyoshi Shimaoka, Teruhiko Koike, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima
BACKGROUND: Fat infiltration within skeletal muscle is known as intramuscular fat (IMF), which increases with aging. Studies have assessed IMF content, using the mid-thigh as a representative location. However, three-dimensional IMF distribution is not well understood. The aim of this study was to compare the IMF content in young and old adults by assessing its distribution along the length of the thigh. METHODS: Consecutive transaxial images of the right thighs in 15 young (age, 21...
February 10, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28137416/effect-of-obturator-nerve-block-during-transurethral-resection-of-lateral-bladder-wall-tumors-on-the-presence-of-detrusor-muscle-in-tumor-specimens-and-recurrence-of-the-disease
#7
Guven Erbay, Fethi Akyol, Mehmet Karabakan, Bulent Celebi, Ercument Keskin, Erkan Hirik
We investigated the effect of spinal anesthesia combined with obturator nerve block (ONB) during the transurethral resection of lateral bladder wall tumors (TUR-BT) on the presence of detrusor muscle tissue in tumor specimens and on tumor recurrence. TUR-BT was performed on 96 patients with a lateral bladder wall tumor under spinal anesthesia in our clinic between January 2011 and December 2015. The patients were divided into two groups: 49 patients only received spinal anesthesia and 47 patients received spinal anesthesia combined with ONB...
February 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28137401/secondary-hyperalgesia-occurs-regardless-of-unilateral-or-bilateral-knee-osteoarthritis-involvement-in-individuals-with-mild-or-moderate-level
#8
Vanessa Martins Pereira Silva Moreira, Saulo Delfino Barboza, Juliana Borges Oliveira, Janser Moura Pereira, Valdeci Carlos Dionisio
BACKGROUND: Secondary hyperalgesia in individuals with less severe levels of knee osteoarthritis remains unclear. The objective of this study was to measure the pressure pain threshold of individuals with mild or moderate knee osteoarthritis and compare with no osteoarthritis. METHODS: Ten healthy controls and 30 individuals with mild or moderate knee osteoarthritis divided into two groups (unilateral and bilateral involvement) were included. Dermatomes in lumbar levels (L1, L2, L3, L4 and L5) and sacral level (S1 and S2), myotomes (vastus medialis, vastus lateralis, rectus femoris, adductor longus, tibialis anterior, peroneus longus, iliacus, quadratus lumborum, and popliteus muscles), and sclerotomes in lumbar levels (L1-L2, L2-L3, L3-L4, L4-L5 supraspinous ligaments), over the L5-S1 and S1-S2 sacral areas, pes anserinus bursae, and at the patellar tendon pressure pain threshold were assessed and compared between individuals with and without knee osteoarthritis...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28119095/unilateral-vocal-fold-adductor-paralysis-after-tracheal-intubation
#9
Takao Goto, Takaharu Nito, Rumi Ueha, Akihito Yamauchi, Taku Sato, Tatsuya Yamasoba
Vocal fold immobility is a relatively rare complication that can occur after tracheal intubation. Differential diagnoses include a rare clinical entity called unilateral vocal fold adductor paralysis in which only branches entering the thyroarytenoid and lateral cricoarytenoid muscles of the recurrent laryngeal nerve become paralyzed. Computed tomography and laryngeal electromyography are required to distinguish this condition from others such as cricoarytenoid dislocation/subluxation. Here, we describe two patients who developed vocal fold adductor paralysis after intubation...
January 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28116876/intratissue-percutaneous-electolysis-epi%C3%A2-combined-with-active-physical-therapy-for-the-treatment-of-adductor-longus-enthesopathy-related-groin-pain-a-randomised-trial
#10
Carlos Moreno, Gabriele Mattiussi, Francisco Javier Núñez, Giovanni Messina, Enrico Rejc
BACKGROUND: Adductor Longus Enthesopathy-related Groin Pain (ALErGP) is the most common cause of groin pain in soccer players. The aim of this study was to evaluate the therapeutic utility of Intratissue Percutaneous Electrolysis (EPI®) technique in combination with an Active Physical Therapy (APT) program to treat ALErGP. METHODS: Twenty-four non-professional male soccer players diagnosed with ALErGP were included in this study and randomly divided into two groups...
January 23, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28113401/an-emg-to-force-processing-approach-for-estimating-in-vivo-hip-muscle-forces-in-normal-human-walking
#11
Ross A Bogey, Lee A Barnes
The force of a single muscle is not directly measurable without invasive methods. Yet invasive techniques are not appropriate for clinical use, thus a non-invasive technique that combined the electromyographic (EMG) signal and a neuromuscular model was developed to determine in vivo active muscle forces at the hip. The EMG-to-force processing (EFP) model included active and passive moment components, and the net EFP moment was compared with the hip moment obtained with standard inverse dynamics techniques ("gold standard")...
October 12, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28079176/adductor-canal-block-versus-femoral-nerve-block-for-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#12
Duan Wang, Yang Yang, Qi Li, Shen-Li Tang, Wei-Nan Zeng, Jin Xu, Tian-Hang Xie, Fu-Xing Pei, Liu Yang, Ling-Li Li, Zong-Ke Zhou
Femoral nerve blocks (FNB) can provide effective pain relief but result in quadriceps weakness with increased risk of falls following total knee arthroplasty (TKA). Adductor canal block (ACB) is a relatively new alternative providing pure sensory blockade with minimal effect on quadriceps strength. The meta-analysis was designed to evaluate whether ACB exhibited better outcomes with respect to quadriceps strength, pain control, ambulation ability, and complications. PubMed, Embase, Web of Science, Wan Fang, China National Knowledge Internet (CNKI) and the Cochrane Database were searched for RCTs comparing ACB with FNB after TKAs...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072900/efficacy-of-adductor-canal-blockade-compared-to-multimodal-peri-articular-analgesia-following-total-knee-arthroplasty
#13
Chukwuweike U Gwam, Jaydev B Mistry, Priya Jha, Anton Khlopas, Melbin Thomas, Morad Chughtai, Michael A Mont, Ronald E Delanois
INTRODUCTION: Postoperative pain after total knee arthroplasty (TKA) can be an impediment to patient recovery. Many commonly used pain control modalities are effective, but are also associated with adverse effects. Other modalities, such as adductor canal blocks (ACB) and multimodal periarticular analgesia (MPA), have gained popularity due to their efficacy and high safety profile. However, to the best of our knowledge, there are no published studies indicating if a therapeutic advantage exists between the two pain control modalities...
January 10, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28066748/the-use-of-platelet-rich-plasma-to-augment-conservative-and-surgical-treatment-of-hip-and-pelvic-disorders
#14
REVIEW
Matthew J Kraeutler, Tigran Garabekyan, Omer Mei-Dan
BACKGROUND: In recent years, platelet-rich plasma (PRP) has gained popularity within the orthopaedic community as a treatment modality to enhance tissue healing. PURPOSE: This review aims to concisely present the current indications for PRP injections in the treatment of hip and pelvic pathologies and to describe some novel applications for PRP which have not yet been reported in the literature. METHODS: We reviewed the literature on the non-operative and operative indications for PRP in the treatment of hip and pelvic pathologies...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28063774/does-addition-of-multimodal-periarticular-analgesia-to-adductor-canal-block-improve-lengths-of-stay-pain-discharge-status-and-opioid-use-after-total-knee-arthroplasty
#15
Chukwuweike U Gwam, Jaydev B Mistry, Anton Khlopas, Morad Chughtai, Melbin Thomas, Michael A Mont, Ronald E Delanois
BACKGROUND: Postoperative pain after total knee arthroplasty (TKA) can be burdensome. Multiple methods of pain control have been used, including adductor canal block (ACB) and multimodal periarticular analgesia (MPA). These two techniques have been studied have proven to be efficacious separately. The purpose of this study was to compare: (1) lengths of stay (LOS), (2) pain level, (3) discharge status, and (4) opioid use in TKA patients who received ACB alone vs patients who received ACB and MPA...
December 14, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28042081/two-short-peptidoglycan-recognition-proteins-from-crassostrea-gigas-with-similar-structure-exhibited-different-pamp-binding-activity
#16
Chuanyan Yang, Lingling Wang, Zhihao Jia, Qilin Yi, Qingsong Xu, Weilin Wang, Changhao Gong, Conghui Liu, Linsheng Song
Peptidoglycan recognition protein (PGRP) is an essential molecule in innate immunity for both invertebrates and vertebrates, owing to its prominent ability in specifically recognizing bacterial peptidoglycan (PGN) and eliminating the invading bacteria. In the present study, the full length cDNA of two PGRP genes, CgPGRPS2 and CgPGRPS4, were cloned from oyster Crassostrea gigas. Their amino acid sequences both contained one signal peptide, one typical PGRP/amidase domain with conserved catalytic residues responsible for amidase activity (55H, 90Y, 164H, 172C in CgPGRPS2, and 98H, 133Y, 207H, 215C in CgPGRPS4), and specific PGN recognition (84R, 85W, 104R, 109V in CgPGRPS2, and 127G, 128W, 147R, 152V in CgPGRPS4), and they shared 55...
December 30, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28033291/adductor-canal-block-versus-femoral-nerve-block-combined-with-sciatic-nerve-block-as-an-anesthetic-technique-for-hindfoot-and-ankle-surgery-a-prospective-randomized-noninferiority-trial
#17
RANDOMIZED CONTROLLED TRIAL
Han Bum Joe, Ho Sik Choo, Ji Sang Yoon, Sang Eon Oh, Jae Ho Cho, Young Uk Park
BACKGROUND: A femoral nerve block (FNB) in combination with a sciatic nerve block (SNB) is commonly used for anesthesia and analgesia in patients undergoing hindfoot and ankle surgery. The effects of FNB on motor function, related fall risk, and rehabilitation are controversial. An adductor canal block (ACB) potentially spares motor fibers in the femoral nerve, but the comparative effect on hindfoot and ankle surgeries between the 2 approaches is not yet well defined. We hypothesized that compared to FNB, ACB would cause less weakness in the quadriceps and produce similar pain scores during and after the operation...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28033266/combined-adductor-canal-block-with-periarticular-infiltration-versus-periarticular-infiltration-for-analgesia-after-total-knee-arthroplasty
#18
Jinhui Ma, Fuqiang Gao, Wei Sun, Wanshou Guo, Zirong Li, Weiguo Wang
BACKGROUND: Both adductor canal block (ACB) and periarticular infiltration (PI) have been shown to reduce pain after total knee arthroplasty (TKA) without the motor blockade. However, the efficacy and safety of combined ACB with PI (ACB + PI) as compared to PI alone for analgesia after TKA remains controversial. We therefore performed a meta-analysis to compare the effects of ACB + PI with PI alone on pain controll after TKA. METHODS: PubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched to identify studies comparing ACB + PI with PI alone for TKA patients...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28025820/adductor-canal-blocks-changing-practice-patterns-and-associated-quality-profile
#19
M M Masaracchia, M D Herrick, M J Barrington, P R Hartmann, B D Sites
BACKGROUND: Femoral nerve blocks have been the gold standard approach for post-operative analgesia following total knee arthroplasty; however, the adductor canal block has recently gained popularity due to less block-induced motor weakness. The primary aim of this time-series analysis was to identify whether regional anesthesia practice changes have occurred for total knee arthroplasty. Our secondary aim was to assess for possible associated changes in safety and quality. METHODS: Using a 20-member clinical registry, we examined the practice patterns and safety around the performance of adductor canal blocks for all total knee arthroplasties between 18 July 2011 to 9 October 2015...
February 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28018077/hip-adductor-pyomyositis-from-streptococcus-mitis-in-a-four-year-old-child
#20
Metin Tolga Buldu, Raghu Raman
: The unique aspect of this case study is the unusual history, presentation, ultrasonography, MRI and blood culture results, which lead to the diagnosis and treatment of adductor pyomyositis with a rare organism in a temperate country. The patient presented with a one-day history of malaise, fever, left groin pain and inability to weight bear on the left leg. There was no history of any trauma, predisposing infections or recent travel. Plain radiograph and ultrasound of the hip was normal with no effusion...
October 2016: Journal of Clinical Orthopaedics and Trauma
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