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Cardiac cobalt

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https://www.readbyqxmd.com/read/27852654/cobalt-cardiomyopathy-a-critical-reappraisal-in-light-of-a-recent-resurgence
#1
Milton Packer
Cobalt can cause a distinctive, rapidly progressive and reversible depression of cardiac systolic function, which is readily distinguished from other causes of cardiomyopathy. Patients present with the subacute onset of severe heart failure, which is accompanied by hypotension and cyanosis, pericardial effusion, low voltage on the electrocardiogram, marked elevation of serum enzymes, and lactic acidosis. They typically have a history of lethargy, anorexia, and weight loss in the months preceding the illness and exhibit other evidence of cobalt's effects on the body (eg, polycythemia and goiter)...
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27816606/surr9c84a-protects-and-recovers-human-cardiomyocytes-from-hypoxia-induced-apoptosis
#2
Ajay Ashok, Jagat Rakesh Kanwar, Uma Maheswari Krishnan, Rupinder Kaur Kanwar
Survivin, as an anti-apoptotic protein and a cell cycle regulator, is recently gaining importance for its regenerative potential in salvaging injured hypoxic cells of vital organs such as heart. Different strategies are being employed to upregulate survivin expression in dying hypoxic cardiomyocytes. We investigated the cardioprotective potential of a cell permeable survivin mutant protein SurR9C84A, for the management of hypoxia mediated cardiomyocyte apoptosis, in a novel and clinically relevant model employing primary human cardiomyocytes (HCM)...
November 2, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27808439/hippocampal-subareas-arranged-in-the-dorsal-ventral-axis-modulate-cardiac-baroreflex-function-in-a-site-dependent-manner-in-rats
#3
Nilson Carlos Ferreira-Junior, Davi Campos Lagatta, Denise Resende Fabri, Fernando Henrique Ferrari Alves, Fernando Morgan Aguiar Corrêa, Leonardo Barbosa Moraes Resstel
From a neuroanatomical point of view, we may split the hippocampal formation into the dorsal (DH) and ventral (VH) hippocampus. Although the basic intrinsic circuitry of the hippocampus seems to be maintained throughout its longitudinal axis, dorsal and ventral portions connect differently with cortical and subcortical areas and express different gene patterns, being functionally distinct. Differential stimulation of the DH or VH can evoke either an increase or a decrease in blood pressure (BP), heart rate (HR) and sympathetic activity...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#4
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
Background Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. Methods We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
October 31, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27730026/the-outcomes-of-patients-with-very-small-coronary-artery-disease-treated-with-thin-strut-cobalt-chromium-bare-metal-stents-an-observational-study
#5
Muhammad Dzafir Ismail, Wan Azman Wan Ahmad, Matthias Leschke, Matthias Waliszewski, Michael Boxberger, Imran Zainal Abidin, Ahmad Syadi Mahmood Zuhdi
BACKGROUND: Percutaneous coronary interventions (PCI) in coronary artery disease (CAD) with very small vessel diameters remains controversial and challenging. These lesions are usually more diffuse, calcified and tortuous. The usage of thin strut bare metal stents (BMS) with excellent crossing profiles in a very small caliber coronary lesions has increased the likelihood of procedural success. OBJECTIVES: This observational study assessed the 9-month clinical outcomes in an 'all-comers' population with very small caliber CAD after implantation of thin strut cobalt chromium BMS...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27698370/attenuation-of-na-k-atpase-mediated-oxidant-amplification-with-pnaktide-ameliorates-experimental-uremic-cardiomyopathy
#6
Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T Shah, Asad A Khawaja, Rebecca Martin, Tylor J Robinette, Adee El-Hamdani, Michael W Dodrill, Komal Sodhi, Christopher A Drummond, Steven T Haller, David J Kennedy, Nader G Abraham, Zijian Xie, Joseph I Shapiro
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27646556/ventrolateral-periaqueductal-grey-matter-neurotransmission-modulates-cardiac-baroreflex-activity
#7
Davi C Lagatta, Nilson C Ferreira-Junior, Milena Deolindo, Fernando M A Corrêa, Leonardo B M Resstel
Baroreflex activity is a neural mechanism responsible for short-term adjustments in blood pressure (BP). Several supramedullary areas, which send projections to the medulla, are able to control this reflex. In this context, the ventrolateral part of the periaqueductal grey matter (vlPAG), which is a mesencephalic structure, has been suggested to regulate the cardiovascular system. However, its involvement in baroreflex control has never been addressed. Therefore, our hypothesis is that the vlPAG neurotransmission is involved in baroreflex cardiac activity...
September 20, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27625684/evaluation-of-safety-and-efficacy-of-nexgen-an-ultrathin-strut-and-hybrid-cell-design-cobalt-chromium-bare-metal-stent-implanted-in-a-real-life-patient-population-the-polish-nexgen-registry
#8
Krzysztof Milewski, Paweł Gąsior, Stefan Samborski, Piotr P Buszman, Aleksandra Błachut, Adam Wojtaszczyk, Adam Młodziankowski, Artur Mendyk, Marek Król, Wojciech Wojakowski, Paweł E Buszman
INTRODUCTION: Despite the dominance of drug-eluting stents in modern interventional cardiology, there is still a niche for bare metal stents. AIM: The aim of the Polish NexGen registry was to evaluate the safety and efficacy of a new generation cobalt-chromium NexGen stent in a real life patient population. MATERIAL AND METHODS: A prospective multi-center registry was conducted in five clinical sites of American Heart of Poland. Three hundred and eighty-three patients who underwent percutaneous coronary intervention (PCI) with NexGen stent implantation were included...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27625144/performance-of-the-xlimus-sirolimus-eluting-coronary-stent-in-very-complex-lesions
#9
Carlo Briguori, Gabriella Visconti, Michael Donahue, Vito Di Palma, Francesca De Micco, Giuseppe Signoriello, Amelia Focaccio
INTRODUCTION: Stent delivery failure may occur especially when treating complex coronary artery stenosis. XLIMUS (CARDIONOVUM GmbH, Bonn, Germany) is a new sirolimus-eluting stent (SES) with the following features: 1) cobalt chromium stent platform, with low (73 μm) strut thickness, (2) biodegradable polymer, and 3) potent antiproliferative drug (Sirolimus). Preliminary data suggest that XLIMUS SES may be ideal for the treatment of complex lesions. METHODS: In this registry, we assessed the deliverability, safety, and efficacy of percutaneous coronary interventions (PCI) using the XLIMUS SES in patients undergoing elective PCI in native coronary vessels for complex de novo lesions, including severe calcification, severe tortuosity, and chronic total occlusion...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27582365/alcoholic-cardiomyopathy-the-result-of-dosage-and-individual-predisposition
#10
B Maisch
The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites...
September 2016: Herz
https://www.readbyqxmd.com/read/27561169/bioresorbable-vascular-scaffolds-for-the-treatment-of-coronary-artery-disease-what-have-we-learned-from-randomized-controlled-clinical-trials
#11
David G Rizik, James B Hermiller, Charles A Simonton, Kevin J Klassen, Dean J Kereiakes
Although current everolimus-eluting coronary stents have shown improved event-free survival within the first year following implantation compared with bare-metal stents or earlier generation drug-eluting stents, they remain associated with an ongoing risk for adverse outcomes (thrombosis, myocardial infarction, and restenosis) beyond 1 year at rates similar to those observed following bare-metal stent deployment. This ongoing very late hazard has been attributed to the permanent presence of the metal frame and/or polymer in these stents...
August 24, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27548501/protective-effects-of-kolaviron-and-gallic-acid-against-cobalt-chloride-induced-cardiorenal-dysfunction-via-suppression-of-oxidative-stress-and-activation-of-the-erk-signaling-pathway
#12
Akinleye Stephen Akinrinde, Olutayo Omobowale, Ademola Oyagbemi, Ebunoluwa Asenuga, Temitayo Ajibade
Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping in athletes and horses. We investigated the protective roles of kolaviron (KV), a bi-flavonoid of Garcinia kola, and gallic acid (GA) on cobalt chloride (CoCl2)-induced cardiorenal damage in rats. CoCl2 caused significant increases (p < 0.05) in serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase (XO), urea, creatinine, malondialdehyde, H2O2, nitric oxide, as well as C-reactive protein expression, along with significant (p < 0...
July 5, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27499948/long-term-performance-of-the-second-generation-cobalt-chromium-sirolimus-eluting-stents-in-real-world-clinical-practice-3-year-clinical-outcomes-from-the-prospective-multicenter-focus-registry
#13
Feng Zhang, Ji'e Yang, Juying Qian, Lei Ge, Jun Zhou, Junbo Ge
BACKGROUND: The short- and mid-term outcomes of the second-generation cobalt-chromium sirolimus-eluting stent (CoCr-SES) in real-world patients had been reported previously, but the long-term performance remained unclear. The objective of this analysis was to evaluate the long-term safety and efficacy of the second-generation CoCr-SES from the FOCUS registry. METHODS: The FOCUS registry (ClinicalTrials.gov Identifier: NCT00868829) enrolled all-comers eligible to receive Firebird-2 CoCr-SES...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27497359/angiographic-complexity-of-coronary-artery-disease-according-to-syntax-score-and-clinical-outcomes-after-revascularisation-with-newer-generation-drug-eluting-stents-a-substudy-of-the-bioscience-trial
#14
Anna Franzone, Masanori Taniwaki, Fabio Rigamonti, Dik Heg, Raffaele Piccolo, Marco Roffi, David Tüller, Olivier Muller, Andre Vuilliomenet, Stéphane Cook, Daniel Weilenmann, Christoph Kaiser, Peiman Jamshidi, Peter Jüni, Stephan Windecker, Thomas Pilgrim
AIMS: We sought to assess the performance of drug-eluting stents combining an ultrathin cobalt-chromium platform with a biodegradable polymer across categories of increasing SYNTAX score (SS). METHODS AND RESULTS: Patients included in the BIOSCIENCE trial and randomly allocated to treatment with biodegradable polymer sirolimus-eluting stents (BP-SES) or durable polymer everolimus-eluting stents (DP-EES) were categorised according to SS tertiles (low <8, medium 8-15, high >15)...
2016: EuroIntervention
https://www.readbyqxmd.com/read/27448538/safety-and-efficacy-of-everolimus-eluting-bioresorbable-vascular-scaffolds-versus-durable-polymer-everolimus-eluting-metallic-stents-assessed-at-1-year-follow-up-a-systematic-review-and-meta-analysis-of-studies
#15
REVIEW
Bertrand N Mukete, Liefke C van der Heijden, Kenneth Tandjung, Hassan Baydoun, Kapil Yadav, Qusai A Saleh, Carine J M Doggen, Nidal Abi Rafeh, Thierry H Le Jemtel, Clemens von Birgelen
BACKGROUND: The Absorb bioresorbable vascular scaffold (BVS) was developed to address long-term safety issues of metallic drug-eluting stents. However, it may be associated with an increased event risk during the first year. METHODS: A systematic literature search was performed (in MEDLINE/PubMed, Cochrane CENTRAL, EMBASE, and scientific meeting abstracts) to identify studies that compared BVS and cobalt-chromium durable polymer everolimus-eluting stents (EES). For randomized clinical trials and non-randomized propensity score matched studies that reported 1-year outcome data, fixed/random-effects models were used to generate pooled estimates of outcomes, presented as odds ratios (OR) with 95%-confidence intervals (CI)...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27443224/systemic-effects-of-cobalt-toxicity-after-revision-hip-replacement-can-manifest-in-intermediate-to-long-term-follow-up
#16
Nijil L Vasukutty, Tahawwar Hasnat Ahmad Minhas
INTRODUCTION: Metal toxicity from metal-on-metal hip replacements is now well documented and several large series have reported local reactions. Although less common, there are reports of similar reactions from failed ceramic liners. Systemic effects documented in literature have been grouped into cardiac, neuro-ocular and thyroid signs. METHODS AND RESULTS: We report a case of a patient who had revision for fractured ceramic liner to metal on polyethylene. Third body effect of the ceramic particles led to wear through of the poly liner and the head directly articulating with metal shell...
2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27412869/randomized-comparison-of-a-biodegradable-polymer-ultrathin-strut-sirolimus-eluting-stent-with-a-biodegradable-polymer-biolimus-eluting-stent-in-patients-treated-with-percutaneous-coronary-intervention-the-sort-out-vii-trial
#17
Lisette Okkels Jensen, Per Thayssen, Michael Maeng, Jan Ravkilde, Lars Romer Krusell, Bent Raungaard, Anders Junker, Christian Juhl Terkelsen, Karsten Tange Veien, Anton Boel Villadsen, Anne Kaltoft, Hans-Henrik Tilsted, Knud Nørregaard Hansen, Jens Aaroe, Steen Dalby Kristensen, Henrik Steen Hansen, Svend Eggert Jensen, Morten Madsen, Hans Erik Bøtker, Klára Berencsi, Jens Flensted Lassen, Evald Høj Christiansen
BACKGROUND: Coronary drug-eluting stents with biodegradable polymers have been designed to improve safety and efficacy. METHODS AND RESULTS: The Scandinavian Organization for Randomized Trials With Clinical Outcome (SORT OUT) VII trial-a large-scale registry-based randomized, multicenter, single-blind, 2-arm, noninferiority trial-compared 2 biodegradable polymer drug-eluting stents: the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent and the stainless steel biolimus-eluting Nobori stent in an all-comer patient population...
July 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27404711/unprotected-left-main-intervention-for-surgery-ineligible-patients-with-coronary-artery-disease-usefulness-of-micro-ct-images-for-stent
#18
Daisuke Sueta, Yuichiro Arima, Seiji Hokimoto, Toshifumi Mukunoki, Noriaki Tabata, Tomonori Akasaka, Takahiro Sato, Jun Otani, Hisao Ogawa
BACKGROUND: Percutaneous coronary intervention (PCI) for unprotected left main truncus (LMT) lesions is controversial. Inoperable status with advanced age, renal dysfunction, frailty, or patient request may require an unprotected left main PCI. PCI for LMT is not recommended in the typical clinical situation; however, when it is the only feasible option, the performance is not bad. We demonstrated the result of a cobalt-chromium everolimus-eluting stent (CoCr-EES) in the LMT stenting and serial changes via micro-computed tomography (μCT)...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27357441/cyclosporin-a-protects-h9c2-cells-against-chemical-hypoxia-induced-injury-via-inhibition-of-mapk-signaling-pathway
#19
Gang Wang, Jie Cui, Yifeng Guo, Yueqiang Wang, Ling Kang, Libo Liu
This study aimed to investigate the effects and molecular mechanism of cyclosporin A (CsA) on cobalt chloride (CoCl2)-induced injury in H9c2 embryonic rat cardiac cells. The results showed that CsA could protect H9c2 cells against CoCl2-induced hypoxic injury. CsA effectively improved cell viability, and decreased LDH leakage, cell apoptosis, MDA concentration, and ROS generation, and increased SOD activity, GSH production, and CAT activity in a dosedependent manner. In addition, CsA treatment blocked the CoCl2-induced increases in ROS production and mitochondrial dysfunction, including a decrease in membrane potential, cytochrome c (cyto-c) release, Bax/Bcl-2 imbalance, as well as the ratios of cl-casp-9/casp-9 and cl-casp-3/casp-3 ratios, via the inhibition of p38 and ERK MAPK signaling pathways...
July 27, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27283837/quercetin-and-vitamin-c-mitigate-cobalt-chloride-induced-hypertension-through-reduction-in-oxidative-stress-and-nuclear-factor-kappa-beta-nf-kb-expression-in-experimental-rat-model
#20
Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Racheal Asenuga, Kabirat Oluwaseun Adigun
The objective of the present work was to evaluate the toxic effects of cobalt chloride, a potent oxidative stress-inducing chemical, at 650 ppm in rats and the protective effect of quercetin and/or vitamin C against the cobalt chloride-induced toxicity. Thirty rats were randomly selected, and assigned to one of five groups: control, cobalt chloride, cobalt chloride + quercetin, cobalt chloride + vitamin C and cobalt chloride + quercetin + vitamin C. The exposure of rats to cobalt chloride led to a significant increase (p < 0...
June 10, 2016: Biological Trace Element Research
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