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https://www.readbyqxmd.com/read/28576627/comparison-of-everolimus-and-biolimus-eluting-coronary-stents-with-everolimus-eluting-bioresorbable-vascular-scaffolds-two-year-clinical-outcomes-of-the-everbio-ii-trial
#1
Diego Arroyo, Gregoire Gendre, Sara Schukraft, Zacharenia Kallinikou, Olivier Müller, Gérard Baeriswyl, Jean-Christophe Stauffer, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
BACKGROUND: Data from randomized controlled trials have shown that the ABSORB BVS is non-inferior to Cobalt Chromium everolimus-eluting stents at 2years. METHODS & RESULTS: The EVERBIO II trial (Comparison of Everolimus- and Biolimus-Eluting Coronary Stents with Everolimus-Eluting Bioresorbable Vascular Scaffold) is a single-center, assessor-blind, randomized controlled trial enrolling 240 patients with an allocation ration of 1:1:1 conducted at University and Hospital Fribourg, Switzerland...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28435089/cobalt-chloride-induces-rhoa-rock-activation-and-remodeling-effect-in-h9c2-cardiomyoblasts-involvement-of-pi3k-akt-and-mapk-pathways
#2
Cheng-I Cheng, Yueh-Hong Lee, Po-Han Chen, Yu-Chun Lin, Ming-Huei Chou, Ying-Hsien Kao
Chronic heart failure is a serious complication of myocardial infarction, one of the major causes of death worldwide that often leads to adverse cardiac hypertrophy and poor prognosis. Hypoxia-induced cardiac tissue remodeling is considered an important underlying etiology. This study aimed to delineate the signaling profiles of RhoA/ROCK, PI3K/Akt, and MAPK and their involvement in regulation of remodeling events in cultured H9c2 cardiomyoblast cells. In addition to its growth-suppressive effect, the hypoxia-mimetic chemical, cobalt chloride (CoCl2) significantly induced RhoA kinase activation as revealed by increased MBS phosphorylation and ROCK1/2 expression in H9c2 cells...
August 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28385356/the-promus-premier-everolimus-eluting-platinum-chromium-stent-with-durable-polymer-evaluated-in-a-real-world-all-comer-population-in-rotterdam-cardiology-hospital-the-p-search-registry
#3
Miguel E Lemmert, Nicolas M van Mieghem, Robert-Jan van Geuns, Roberto Diletti, Rutger J van Bommel, Ron T van Domburg, Peter P de Jaegere, Evelyn Regar, Felix Zijlstra, Eric Boersma, Joost Daemen
BACKGROUND: A new-generation everolimus eluting platinum-chromium stent (EePCS), offering improved radial strength, radiopacity and conformability compared to everolimus-eluting cobalt-chromium stents (EeCCS), was evaluated with regard to safety and efficacy in an all-comer cohort. METHODS: A total of 1000 consecutive all-comer patients (including acute coronary syndrome, multivessel disease, calcified lesions) treated with an EePCS (Promus Premier™, Boston Scientific, Natick, Massachusetts) from May 2013 to October 2014 were compared to 1000 consecutive patients treated with an EeCCS (Xience Prime™, Abbott Vascular, Santa Clara, California) from April 2012 to May 2013...
March 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28279316/the-remedee-oct-study-an-evaluation-of-the-bioengineered-combo-dual-therapy-cd34-antibody-covered-sirolimus-eluting-coronary-stent-compared-with-a-cobalt-chromium-everolimus-eluting-stent-in-patients-with-acute-coronary-syndromes-insights-from-optical-coherence
#4
Milosz Jaguszewski, Romila Aloysius, Wei Wang, Hiram G Bezerra, Jonathan Hill, Robbert J De Winter, Pasi P Karjalainen, Stefan Verheye, William Wijns, Thomas F Lüscher, Michael Joner, Marco Costa, Ulf Landmesser
OBJECTIVES: The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. BACKGROUND: CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cell-capturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the vascular response are needed...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28259939/the-role-of-zfp580-a-novel-zinc-finger-protein-in-tgf-mediated-cytoprotection-against-chemical-hypoxia%C3%A2-induced-apoptosis-in-h9c2-cardiac-myocytes
#5
Shi-Yun Mao, Xiang-Yan Meng, Zhong-Wei Xu, Wen-Cheng Zhang, Xiao-Han Jin, Xi Chen, Xin Zhou, Yu-Ming Li, Rui-Cheng Xu
Zing finger protein 580 (ZFP580) is a novel Cys2-His2 zinc-finger transcription factor that has an anti-apoptotic role in myocardial cells. It is involved in the endothelial transforming growth factor‑β1 (TGF‑β1) signal transduction pathway as a mothers against decapentaplegic homolog (Smad)2 binding partner. The aim of the present study was to determine the involvement of ZFP580 in TGF‑β1‑mediated cytoprotection against chemical hypoxia‑induced apoptosis, using H9c2 cardiac myocytes. Hypoxia was chemically induced in H9c2 myocardial cells by exposure to cobalt chloride (CoCl2)...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28114618/five-year-outcome-after-implantation-of-zotarolimus-and-everolimus-eluting-stents-in-randomized-trial-participants-and-nonenrolled-eligible-patients-a-secondary-analysis-of-a-randomized-clinical-trial
#6
Clemens von Birgelen, Liefke C van der Heijden, Mounir W Z Basalus, Marlies M Kok, Hanim Sen, Hans W Louwerenburg, K Gert van Houwelingen, Martin G Stoel, Frits H A F de Man, Gerard C M Linssen, Kenneth Tandjung, Carine J M Doggen, Job van der Palen, Marije M Löwik
Importance: Long-term follow-up after a clinical trial of 2 often-used, newer-generation drug-eluting stents (DESs) in a broad patient population is of interest. Comprehensive long-term outcome of eligible nonenrolled patients has never been reported. Objective: To assess 5-year safety and efficacy of 2 newer-generation DESs in randomized participants with non-ST-elevation acute coronary syndromes or stable angina and to evaluate long-term outcomes of nonenrolled eligible patients treated with the same DESs...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28112473/efficacy-and-safety-of-a-biodegradable-polymer-cobalt-chromium-sirolimus-eluting-stent-excel2-in-treating-de-novo-coronary-artery-disease-a-pooled-analysis-of-the-credit-ii-and-credit-iii-trials
#7
Geng Wang, Heyang Wang, Bo Xu, Yuejin Yang, Zhiming Yang, Hui Li, Zheng Zhang, Haichang Wang, Lixia Yang, Yaling Han
BACKGROUND: The safety and efficacy of the second-generation biodegradable polymer Cobalt-Chromium sirolimus-eluting stent (EXCEL2) in daily clinical practice remains unknown. Additionally, to meet the China Food and Drug Administration requirements, we conducted an objective performance criterion study from the CREDIT II and CREDIT III trials. METHODS: CREDIT II was a randomized trial comparing the EXCEL2 versus EXCEL stent in patients with up to 2 de novo coronary lesions...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28067198/outcomes-of-patients-treated-with-durable-polymer-platinum-chromium-everolimus-eluting-stents-a-meta-analysis-of-randomized-trials
#8
Salvatore Cassese, Gjin Ndrepepa, Robert A Byrne, Sebastian Kufner, Erion Xhepa, Antoinette de Waha, Tobias Rheude, Roisin Colleran, Daniele Giacoppo, Yukinori Harada, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati
AIMS: The durable-polymer platinum-chromium everolimus-eluting stent (PtCr-EES) is a new- generation drug-eluting stent (DES) with a platinum-enriched metallic platform developed to improve the percutaneous treatment of patients with coronary artery disease. We sought to investigate the performance of durable-polymer PtCr-EES versus other new-generation DES. METHODS AND RESULTS: We undertook a meta-analysis of trials, in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to durable-polymer PtCr-EES versus other new-generation DES (other DES)...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28047209/su-c-brc-01-a-monte-carlo-study-of-out-of-field-doses-from-cobalt-60-teletherapy-units-intended-for-historical-correlations-of-dose-to-normal-tissue
#9
H Petroccia, E Olguin, W Culberson, B Bednarz, N Mendenhall, W Bolch
PURPOSE: Innovations in radiotherapy treatments, such as dynamic IMRT, VMAT, and SBRT/SRS, result in larger proportions of low-dose regions where normal tissues are exposed to low doses levels. Low doses of radiation have been linked to secondary cancers and cardiac toxicities. The AAPM TG Committee No.158 entitled, 'Measurements and Calculations of Doses outside the Treatment Volume from External-Beam Radiation Therapy', has been formed to review the dosimetry of non-target and out-of-field exposures using experimental and computational approaches...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27993758/first-in-man-six-month-results-of-a-surface-modified-coronary-stent-system-in-native-coronary-stenosis
#10
Pannipa Suwannasom, Yohei Sotomi, Roberto Corti, David J Kurz, Marco Roffi, Clemens von Birgelen, Stefano Buzzi, Arik Zucker, Jouke Dijkstra, Joanna J Wykrzykowska, Robbert J de Winter, Stephan Windecker, Yoshinobu Onuma, Patrick W Serruys, Joost Daemen, Lorenz Räber
AIMS: In preclinical studies, a bare metal cobalt-chromium stent with an active surface oxide layer modification (BMSmod) has been shown to inhibit neointimal hyperplasia effectively. We sought to assess both the clinical safety and feasibility of the BMSmod. METHODS AND RESULTS: In this prospective, non-randomised, first-in-man multicentre study, a total of 31 patients with de novo coronary lesions, reference lumen diameters of 2.5-3.5 mm and lesion length ≤16 mm, were enrolled...
April 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/27852654/cobalt-cardiomyopathy-a-critical-reappraisal-in-light-of-a-recent-resurgence
#11
REVIEW
Milton Packer
Cobalt can cause a distinctive, rapidly progressive and reversible depression of cardiac systolic function, which is readily distinguished from other causes of cardiomyopathy. Patients present with the subacute onset of severe heart failure, which is accompanied by hypotension and cyanosis, pericardial effusion, low voltage on the electrocardiogram, marked elevation of serum enzymes, and lactic acidosis. They typically have a history of lethargy, anorexia, and weight loss in the months preceding the illness and exhibit other evidence of cobalt's effects on the body (eg, polycythemia and goiter)...
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27816606/surr9c84a-protects-and-recovers-human-cardiomyocytes-from-hypoxia-induced-apoptosis
#12
Ajay Ashok, Jagat Rakesh Kanwar, Uma Maheswari Krishnan, Rupinder Kaur Kanwar
Survivin, as an anti-apoptotic protein and a cell cycle regulator, is recently gaining importance for its regenerative potential in salvaging injured hypoxic cells of vital organs such as heart. Different strategies are being employed to upregulate survivin expression in dying hypoxic cardiomyocytes. We investigated the cardioprotective potential of a cell permeable survivin mutant protein SurR9C84A, for the management of hypoxia mediated cardiomyocyte apoptosis, in a novel and clinically relevant model employing primary human cardiomyocytes (HCM)...
January 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/27808439/hippocampal-subareas-arranged-in-the-dorsoventral-axis-modulate-cardiac-baroreflex-function-in-a-site-dependent-manner-in-rats
#13
Nilson Carlos Ferreira-Junior, Davi Campos Lagatta, Denise Resende Fabri, Fernando Henrique Ferrari Alves, Fernando Morgan Aguiar Corrêa, Leonardo Barbosa Moraes Resstel
What is the central question of this study? Classically, areas of the brainstem are involved in the cardiac baroreceptor reflex. However, forebrain areas, such as the hippocampus, may also modulate the cardiac baroreflex function. What is the main finding and its importance? According to the hippocampal subarea recruited dorsoventrally, the baroreflex function can be either facilitated or inhibited. These results are according to the new topographical division proposed for the hippocampus, i.e. it can be divided into functionally and anatomically different regions along its dorsoventral axis...
January 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/27797291/everolimus-eluting-stents-or-bypass-surgery-for-left-main-coronary-artery-disease
#14
RANDOMIZED CONTROLLED TRIAL
Gregg W Stone, Joseph F Sabik, Patrick W Serruys, Charles A Simonton, Philippe Généreux, John Puskas, David E Kandzari, Marie-Claude Morice, Nicholas Lembo, W Morris Brown, David P Taggart, Adrian Banning, Béla Merkely, Ferenc Horkay, Piet W Boonstra, Ad J van Boven, Imre Ungi, Gabor Bogáts, Samer Mansour, Nicolas Noiseux, Manel Sabaté, José Pomar, Mark Hickey, Anthony Gershlick, Pawel Buszman, Andrzej Bochenek, Erick Schampaert, Pierre Pagé, Ovidiu Dressler, Ioanna Kosmidou, Roxana Mehran, Stuart J Pocock, A Pieter Kappetein
BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients)...
December 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27730026/the-outcomes-of-patients-with-very-small-coronary-artery-disease-treated-with-thin-strut-cobalt-chromium-bare-metal-stents-an-observational-study
#15
Muhammad Dzafir Ismail, Wan Azman Wan Ahmad, Matthias Leschke, Matthias Waliszewski, Michael Boxberger, Imran Zainal Abidin, Ahmad Syadi Mahmood Zuhdi
BACKGROUND: Percutaneous coronary interventions (PCI) in coronary artery disease (CAD) with very small vessel diameters remains controversial and challenging. These lesions are usually more diffuse, calcified and tortuous. The usage of thin strut bare metal stents (BMS) with excellent crossing profiles in a very small caliber coronary lesions has increased the likelihood of procedural success. OBJECTIVES: This observational study assessed the 9-month clinical outcomes in an 'all-comers' population with very small caliber CAD after implantation of thin strut cobalt chromium BMS...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27698370/attenuation-of-na-k-atpase-mediated-oxidant-amplification-with-pnaktide-ameliorates-experimental-uremic-cardiomyopathy
#16
Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T Shah, Asad A Khawaja, Rebecca Martin, Tylor J Robinette, Adee El-Hamdani, Michael W Dodrill, Komal Sodhi, Christopher A Drummond, Steven T Haller, David J Kennedy, Nader G Abraham, Zijian Xie, Joseph I Shapiro
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27646556/ventrolateral-periaqueductal-grey-matter-neurotransmission-modulates-cardiac-baroreflex-activity
#17
Davi C Lagatta, Nilson C Ferreira-Junior, Milena Deolindo, Fernando M A Corrêa, Leonardo B M Resstel
Baroreflex activity is a neural mechanism responsible for short-term adjustments in blood pressure (BP). Several supramedullary areas, which send projections to the medulla, are able to control this reflex. In this context, the ventrolateral part of the periaqueductal grey matter (vlPAG), which is a mesencephalic structure, has been suggested to regulate the cardiovascular system. However, its involvement in baroreflex control has never been addressed. Therefore, our hypothesis is that the vlPAG neurotransmission is involved in baroreflex cardiac activity...
December 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27625684/evaluation-of-safety-and-efficacy-of-nexgen-an-ultrathin-strut-and-hybrid-cell-design-cobalt-chromium-bare-metal-stent-implanted-in-a-real-life-patient-population-the-polish-nexgen-registry
#18
Krzysztof Milewski, Paweł Gąsior, Stefan Samborski, Piotr P Buszman, Aleksandra Błachut, Adam Wojtaszczyk, Adam Młodziankowski, Artur Mendyk, Marek Król, Wojciech Wojakowski, Paweł E Buszman
INTRODUCTION: Despite the dominance of drug-eluting stents in modern interventional cardiology, there is still a niche for bare metal stents. AIM: The aim of the Polish NexGen registry was to evaluate the safety and efficacy of a new generation cobalt-chromium NexGen stent in a real life patient population. MATERIAL AND METHODS: A prospective multi-center registry was conducted in five clinical sites of American Heart of Poland. Three hundred and eighty-three patients who underwent percutaneous coronary intervention (PCI) with NexGen stent implantation were included...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27625144/performance-of-the-xlimus-sirolimus-eluting-coronary-stent-in-very-complex-lesions
#19
Carlo Briguori, Gabriella Visconti, Michael Donahue, Vito Di Palma, Francesca De Micco, Giuseppe Signoriello, Amelia Focaccio
INTRODUCTION: Stent delivery failure may occur especially when treating complex coronary artery stenosis. XLIMUS (CARDIONOVUM GmbH, Bonn, Germany) is a new sirolimus-eluting stent (SES) with the following features: 1) cobalt chromium stent platform, with low (73 μm) strut thickness, (2) biodegradable polymer, and 3) potent antiproliferative drug (Sirolimus). Preliminary data suggest that XLIMUS SES may be ideal for the treatment of complex lesions. METHODS: In this registry, we assessed the deliverability, safety, and efficacy of percutaneous coronary interventions (PCI) using the XLIMUS SES in patients undergoing elective PCI in native coronary vessels for complex de novo lesions, including severe calcification, severe tortuosity, and chronic total occlusion...
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27582365/alcoholic-cardiomyopathy-the-result-of-dosage-and-individual-predisposition
#20
B Maisch
The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites...
September 2016: Herz
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