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https://www.readbyqxmd.com/read/28239999/glioblastoma-multiforme-a-review-of-its-epidemiology-and-pathogenesis-through-clinical-presentation-and-treatment
#1
Farina Hanif, Kanza Muzaffar, Kahkashan Perveen, Saima M Malhi, Shabana U Simjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. Despite advances in treatment modalities it remains largely incurable. The objective of our review is to provide a holistic picture of GBM epidemiology, etiology, pathogenesis, clinical findings and treatment. A literature search was conducted for GBM at PubMed and Google Scholar, with relevant key words like glioblastoma multiforme, pathogenesis, signs and symptoms, treatment etc., and papers published until 2015 were reviewed...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239886/fibrocartilaginous-mesenchymoma-of-bone-a-single-institution-experience-with-molecular-investigations-and-a-review-of-the-literature
#2
M Gambarotti, A Righi, D Vanel, S Cocchi, S Benini, F M Elli, G Mantovani, P Ruggieri, S Boriani, D Donati, M Sbaraglia, A P Dei Tos, P Picci
AIMS: Fibrocartilaginous mesenchymoma is a rare intraosseous lesion with a total of 25 cases described in the literature. This study describes the clinical, radiological, and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, dedifferentiated chondrosarcoma, and low-grade osteosarcoma...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28239663/radiographic-indices-for-lumbar-developmental-spinal-stenosis
#3
Jason Pui Yin Cheung, Karen Ka Man Ng, Prudence Wing Hang Cheung, Dino Samartzis, Kenneth Man Chee Cheung
BACKGROUND: Patients with developmental spinal stenosis (DSS) are susceptible to developing symptomatic stenosis due to pre-existing narrowed spinal canals. DSS has been previously defined by MRI via the axial anteroposterior (AP) bony spinal canal diameter. However, MRI is hardly a cost-efficient tool for screening patients. X-rays are superior due to its availability and cost, but currently, there is no definition of DSS based on plain radiographs. Thus, the aim of this study is to develop radiographic indices for diagnosing DSS...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28239593/ectopic-esthesioneuroblastoma-of-the-sphenoclivus-a-rare-entity
#4
Farah Dayana Zahedi, Balwant Singh Gendeh, Salina Husain, Ramesh Kumar, Thean Yean Kew
Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management, We report a rare case of ectopic esthesioneuroblastoma of the sphenoclivus with the presentation of intermittent unilateral epistaxis, intermittent intractable headache without anosmia. Nasal endoscopy findings showed a pulsatile mass at the anterior face of the sphenoid sinus with extension posteriorly towards the clivus region and occupying the floor of the sphenoid sinus...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239585/imaging-in-juvenile-nasopharyngeal-angiofibroma-clinical-significance-of-ramharan-and-chopstick-sign
#5
Trichy Narayanan Janakiram, Shilpee Bhatia Sharma, Udaya Chanukya Samavedam, Onkar Deshmukh, Bavaharan Rajalingam
Imaging plays an important role in the diagnosis, staging and prognosis of JNA. Certain radiological changes as seen on CECT were observed to be consistent in our case series. This study analysed preoperative and postoperative CECT of large series of JNA patients to evaluate the sites and pattern of spread of tumor. We evaluated the clinical significance of pterygoid wedge in preoperative and postoperative imaging and thus elucidating two new radiological signs. Retrospective analysis of the pre operative and post operative imaging data of 242 patients with JNA...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239520/association-of-vitamin-d-status-and-clinical-and-radiological-outcomes-in-a-treated-ms-population-in-poland
#6
Sławomir Wawrzyniak, Emilia Mikołajewska, Ewelina Kuczko-Piekarska, Anna Niezgodzińska-Maciejek, Aleksander Goch
BACKGROUND: Vitamin D influences the immune system significantly. Previous studies have found that vitamin D deficiency in adolescence can play a significant role in increasing the risk of developing autoimmune diseases including multiple sclerosis. The aim of this study was to investigate the relationship between the vitamin D status in serum and clinical and radiological outcomes in a treated population in Poland. METHODS: Inclusion criteria met 83 adult patients aged 20-61 years with diagnosis of relapsing-remitting multiple sclerosis, who underwent immunomodulatory treatment which lasted at least 12 months...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239500/a-pediatric-tumor-found-frequently-in-the-adult-population-a-case-of-anaplastic-astroblastoma-in-an-elderly-patient-and-review-of-the-literature
#7
Christopher Payne, Ali Batouli, Kristen Stabingas, Dunbar Alcindor, Khaled Abdel Aziz, Cunfeng Pu, Elizabeth Tyler-Kabara, Robert Williams, Alexander Yu
Astroblastomas are rare, potentially curable primary brain tumors which can be difficult to diagnose. We present the case of astroblastoma in a 73-year-old male, an atypical age for this tumor, more classically found in pediatric and young adult populations. Through our case and review of the literature, we note that this tumor is frequently reported in adult populations and the presentation of this tumor in the elderly is well described. This tumor is an important consideration in the differential diagnosis when managing both pediatric and adult patients of any age who present with the imaging findings characteristic of this rare tumor...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28239455/the-underlying-mechanism-of-prodromal-pd-insights-from-the-parasympathetic-nervous-system-and-the-olfactory-system
#8
REVIEW
Shu-Ying Liu, Piu Chan, A Jon Stoessl
Neurodegeneration of Parkinson's disease (PD) starts in an insidious manner, 30-50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, during which the disease pathology has started but is insufficient to result in clinical manifestations, offers a valuable window for disease-modifying therapies. The most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of neurons...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28238701/deep-brain-stimulation-of-the-subcallosal-cingulate-for-treatment-refractory-anorexia-nervosa-1-year-follow-up-of-an-open-label-trial
#9
Nir Lipsman, Eileen Lam, Matthew Volpini, Kalam Sutandar, Richelle Twose, Peter Giacobbe, Devin J Sodums, Gwenn S Smith, D Blake Woodside, Andres M Lozano
BACKGROUND: Anorexia nervosa is a life-threatening illness. Brain circuits believed to drive anorexia nervosa symptoms can be accessed with surgical techniques such as deep brain stimulation (DBS). Initial results suggest that DBS of the subcallosal cingulate is safe and associated with improvements in mood and anxiety. Here, we investigated the safety, clinical, and neuroimaging outcomes of DBS of the subcallosal cingulate in a group of patients during 12 months of active stimulation...
February 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28238666/clinical-impact-of-second-opinion-musculoskeletal-subspecialty-interpretations-during-a-multidisciplinary-orthopedic-oncology-conference
#10
Aleksandr Rozenberg, Barry E Kenneally, John A Abraham, Kristin Strogus, Johannes B Roedl, William B Morrison, Adam C Zoga
PURPOSE: To analyze the impact on clinical management when musculoskeletal radiologists render second-opinion consultations during multidisciplinary orthopedic oncology conference. METHODS: A PACS database was searched for secondary interpretations on outside MRI studies reviewed during a multidisciplinary orthopedic oncology conference from January 2014 to December 2016. Reports were compared with the original interpretations, when available. Reports were categorized using a 7-point scale: I (no discrepancy), II (undetected clinically insignificant abnormality), III (clinically insignificant difference in interpretation), IV (difference in imaging follow-up recommendation), V (equivocal initial interpretation with subsequent definitive subspecialty interpretation), VI (clinically significant difference in interpretation), VII (failure to detect a clinically significant abnormality)...
February 23, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28238562/evaluation-of-maxillary-sinus-after-le-fort-i-osteotomy-using-various-fixation-materials
#11
Koichiro Ueki, Kunio Yoshizawa, Akinori Moroi, Asami Hotta, Takamitsu Tsutsui, Kenichi Fukaya, Ryota Hiraide, Akihiro Takayama, Tatsuya Tsunoda, Yuki Saito, Ran Iguchi, Akihiko Kosaka, Hiroumi Ikawa
PURPOSE: The purpose of this study was to evaluate maxillary sinus and predict the factors affecting the postoperative sinus condition after Le Fort I osteotomy using various fixation materials. MATERIALS AND METHODS: The study subjects consisted of 71 patients (21 male and 50 female, 142 sides) who underwent Le Fort I osteotomy with sagittal split ramus osteotomy. The maxillary sinus bony area and the inside air area were measured in the coronal plane across the mesial aspect of the first molar perpendicular to the Frankfurt horizontal plane of a computed tomography (CT) image preoperatively and at 1 week and 1 year after surgery...
January 31, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28238560/diagnostic-and-therapeutic-modalities-for-287-malignant-and-benign-salivary-tumors-a-cohort-study
#12
Yair Israel, Adi Rachmiel, Gil Ziv, Rafael Nagler
BACKGROUND: Salivary gland tumors (SGT's), 3-10% of head/neck tumors, exhibit a striking range of morphological diversity. This minimally symptomatic disease can be challenging to diagnose, and therapeutic policy is still controversial. METHODS: We compared benign and malignant cohorts according to diagnostic modality utilized and therapeutic modality administered over 20 years in a single medical center. RESULTS: Of 287 cases, 216 had benign tumors and 71 had malignant tumors...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28238497/structured-clinical-decision-aids-are-seldom-compared-with-subjective-physician-judgment-and-are-seldom-superior
#13
David L Schriger, Joshua W Elder, Richelle J Cooper
STUDY OBJECTIVE: We determine how often studies that evaluate the performance of an aid for decisionmaking, be it a simple laboratory or imaging test or a complex multielement decision instrument, compare the aid's performance to independent, unaided physician judgment. METHODS: This was a cross-sectional survey of all Original Research and Brief Research Report articles in Annals of Emergency Medicine from 1998 to 2015. We included all articles that evaluated the performance of an aid for decisionmaking in assisting a physician with a decision about testing, treatment, diagnosis, or disposition...
February 23, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28238385/distributive-shock-in-the-emergency-department-sepsis-anaphylaxis-or-capillary-leak-syndrome
#14
Cansu Alyeşil, Nurettin Özgür Doğan, İbrahim Ulaş Özturan, Seda Güney
BACKGROUND: Distributive shock is a hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage. Although the most common etiology is septic shock, anaphylactic and other etiologies should be considered. CASE REPORT: We report the case of a 30-year-old female who presented to the emergency department with nonspecific symptoms and hypotension after a viral upper respiratory infection...
February 18, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28238226/dual-energy-ct-in-gout-a-review-of-current-concepts-and-applications
#15
REVIEW
Hong Chou, Teck Yew Chin, Wilfred C G Peh
Dual-energy computed tomography (DECT) is a relatively recent development in the imaging of gouty arthritis. Its availability and usage have become increasingly widespread in recent years. DECT is a non-invasive method for the visualisation, characterisation and quantification of monosodium urate crystal deposits which aids the clinician in the early diagnosis, treatment and follow-up of this condition. This article aims to give an up to date review and summary of existing literature on the role and accuracy of DECT in the imaging of gout...
February 26, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#16
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28237925/hep-2-specimen-image-segmentation-and-classification-using-very-deep-fully-convolutional-network
#17
Yuexiang Li, Linlin Shen, Shiqi Yu
Reliable identification of Human Epithelial-2 (HEp-2) cell patterns can facilitate the diagnosis of systemic autoimmune diseases. However, traditional approach requires experienced experts to manually recognize the cell patterns, which suffers from the inter-observer variability. In this paper, an automatic pattern recognition system using fully convolutional network (FCN) was proposed to simultaneously address the segmentation and classification problem of HEp-2 specimen images. The proposed system transforms the residual network (ResNet) to fully convolutional residual network (FCRN) enabling the network to perform semantic segmentation task...
February 22, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28237773/review-of-post-ischemic-stroke-imaging-and-its-clinical-relevance
#18
Leonard L L Yeo, Benjamin Y Q Tan, Tommy Andersson
In this day and age, multiple imaging modalities are available to the stroke physician in the post-treatment phase.The practical challenge for physicians who treat stroke is to evaluate the pros and cons of each technique and select the best choice for the situation. The choice of imaging modality remains contentious at best and varies among different institutions and centres. This is no simple task an there are many factors to consider, including the differential diagnosis which need to be evaluated, the availability and reliability of the imaging technique and time and expertise required to perform and interpret the scanning...
February 14, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28237771/-primary-intramedullary-melanoma-case-report-and-literature-review
#19
Yislenz Narváez-Martínez, Napoleón de la Ossa, Raquel López-Martos, Carlos Cohn-Reinoso, Marina Castellví-Juan, Secundino Martin-Ferrer
A dark pigmented intramedullary mass is very rarely encountered in daily practice, and poses a diagnostic challenge. Several entities have to be considered, including melanin-containing tumours (melanotic ependymoma and melanotic schwannoma) and melanocyte-containing tumours (melanocytoma, primary melanoma and melanoma metastases). The case is presented of a 47 year-old male with a pigmented intramedullary tumour located at T7-T8 level. Magnetic resonance images (MRI) revealed a tumour with hyperintensity on T1 and hypointensity on T2...
February 22, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28237644/surgery-for-pancreatic-neoplasms-how-accurate-are-our-surgical-indications
#20
David Jérémie Birnbaum, Sébastien Gaujoux, Julie Berbis, Safi Dokmak, Pascal Hammel, Marie Pierre Vullierme, Philippe Lévy, Alain Sauvanet
BACKGROUND: Accurate preoperative diagnosis is critical for the determination of appropriate surgical indications. The aim of this study was to assess the accuracy of preoperative diagnosis and indications for operative therapy for presumed pancreatic neoplasms. METHODS: From 2005 to 2013, 851 patients underwent pancreatectomies for presumed pancreatic neoplasms. A formal preoperative diagnosis was established during a multidisciplinary tumor board and compared to the final pathologic examination...
February 22, 2017: Surgery
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