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https://www.readbyqxmd.com/read/28224960/-elderly-women-and-alcohol
#1
Alba Moscato
It is important to understand the reasons for alcohol abuse in elderly people and in particular women. Psychological suffering must be envisaged. This behaviour can be considered as a necessary narcissistic retreat when ageing. The mental health of these women should be taken into account when providing them with help when they want it. This involves understanding them and supporting them as they adjust to the passage of time.
January 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28224957/-medicines-and-elderly-patients-abuse-dependency-or-attraction
#2
Pascal Menecier, Laure Menecier-Ossia
Psychotropic medicines represent, after alcohol, the second class of substances most susceptible to abuse by elderly people. It can be particularly difficult for caregivers to understand such behaviour as these are prescription-only medicines. This misuse is partly a result of older people tending to trivialise and overrate pharmaceutical drugs, ignoring the potential of non-medicinal methods and psychotherapeutic treatments. The boundaries between prescribed use, overuse, self-medication, excessive use, dependency or addiction to prescription drugs are blurred in older people...
January 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28224686/addiction-research-and-theory-a-commentary-on-the-surgeon-general-s-report-on-alcohol-drugs-and-health
#3
Aldo Badiani, Kent C Berridge, Markus Heilig, David J Nutt, Terry E Robinson
The Office of the Surgeon General recently produced its first Report on the consequences of alcohol and drug abuse on health, making several very laudable policy recommendations. The Report also emphasizes the importance of adequate funding for biomedical research, which is good news for both researchers and patients. However, the Report is marred by a biased viewpoint on the psychology and neurobiology of drug addiction. We highlight here four controversial issues that were depicted as facts in the Report, thereby potentially misleading non-expert readers about the current state-of-the-art understanding of the psychology and neurobiology of drug addiction...
February 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28220762/drug-detection-in-breath-non-invasive-assessment-of-illicit-or-pharmaceutical-drugs
#4
Phillip Trefz, Svend Kamysek, Patricia Fuchs, Pritam Sukul, Jochen Schubert, Wolfram Miekisch
Breath analysis not only holds great potential for the development of new non-invasive diagnostic methods, but also for the identification and follow up of drug levels in breath. This is of interest for both, forensic and medical science. On the one hand, the detection of drugs of abuse in exhaled breath - similar to the well-known breath alcohol tests - would be highly desirable as an alternative to blood or urine analysis in situations such as police controls for drugged driving. The noninvasive detection of drugs and their metabolites is thus of great interest in forensic science, especially since marijuana is becoming legalized in certain parts of the U...
February 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28220214/the-epidemiology-of-alcohol-use-in-izmir-turkey-drinking-pattern-impairment-and-help-seeking
#5
Halis Ulaş, Tolga Binbay, Umut Kırlı, Hayriye Elbi, Köksal Alptekin
PURPOSE: There is no report on various patterns of alcohol drinking and related impairment, help-seeking in Turkey. We investigated the 12-month prevalence and correlates of drinking patterns and alcohol use disorders in the general population of Izmir-Turkey, with further analyses on role impairment and help-seeking. METHOD: A multi-stage clustered area probability sample of adult household residents in the Izmir Metropolitan Area was assessed using the Composite International Diagnostic Interview 2...
February 20, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28218795/defensive-coping-and-essential-amino-acid-markers-as-possible-predictors-for-structural-vascular-disease-in-an-african-and-caucasian-male-cohort-the-sabpa-study
#6
Marisa Möller, Leoné Malan, Martin Magnusson, Carina M C Mels, Nico T Malan
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. The Coping Strategy Indicator questionnaire identified DefS participants...
February 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28218632/clinical-case-of-the-month-group-g-streptococcal-bacteremia-secondary-to-a-burn-wound-infection
#7
Paige Deichmann, Amol Sura, Charles Sanders, Nisha Aravindakshan-Patel, Fred Lopez
A 61-year-old man presented to the emergency department with second degree burns along his right arm and hand. He reported that his knees suddenly gave out while holding a pot of soup resulting in the scalding liquid spilling over his arm. His medical history is significant for alcohol abuse, chronic obstructive pulmonary disease, atrial fibrillation, congestive heart failure with preserved ejection fraction, chronic knee instability, and degenerative joint disease of the spine.
January 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28216980/long-term-prognosis-in-patients-continuing-taking-antithrombotics-after-peptic-ulcer-bleeding
#8
Xi-Xu Wang, Bo Dong, Biao Hong, Yi-Qun Gong, Wei Wang, Jue Wang, Zhen-Yu Zhou, Wei-Jun Jiang
AIM: To investigate the long-term prognosis in peptic ulcer patients continuing taking antithrombotics after ulcer bleeding, and to determine the risk factors that influence the prognosis. METHODS: All clinical data of peptic ulcer patients treated from January 1, 2009 to January 1, 2014 were retrospectively collected and analyzed. Patients were divided into either a continuing group to continue taking antithrombotic drugs after ulcer bleeding or a discontinuing group to discontinue antithrombotic drugs...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28215999/rat-animal-models-for-screening-medications-to-treat-alcohol-use-disorders
#9
REVIEW
Richard L Bell, Sheketha R Hauser, Tiebing Liang, Youssef Sari, Antoinette Maldonado-Devincci, Zachary A Rodd
The purpose of this review is to present animal research models that can be used to screen and/or repurpose medications for the treatment of alcohol abuse and dependence. The focus will be on rats and in particular selectively bred rats. Brief introductions discuss various aspects of the clinical picture, which provide characteristics of individuals with alcohol use disorders (AUDs) to model in animals. Following this, multiple selectively bred rat lines will be described and evaluated in the context of animal models used to screen medications to treat AUDs...
February 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28215541/evaluation-of-a-combinational-use-of-serum-micrornas-as-biomarkers-for-liver-diseases
#10
Ping Xu, Anliang Guo, Junchi Xu, Jianer Yao, Hui Chen, Fengping Wang, Chuanwu Zhu
Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT...
February 16, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28214667/effects-of-prior-testing-lasting-a-full-year-in-ncanda-adolescents-contributions-from-age-sex-socioeconomic-status-ethnicity-site-family-history-of-alcohol-or-drug-abuse-and-baseline-performance
#11
Edith V Sullivan, Ty Brumback, Susan F Tapert, Devin Prouty, Rosemary Fama, Wesley K Thompson, Sandra A Brown, Kevin Cummins, Ian M Colrain, Fiona C Baker, Duncan B Clark, Tammy Chung, Michael D De Bellis, Stephen R Hooper, Bonnie J Nagel, B Nolan Nichols, Weiwei Chu, Dongjin Kwon, Kilian M Pohl, Adolf Pfefferbaum
Longitudinal study provides a robust method for tracking developmental trajectories. Yet inherent problems of retesting pose challenges in distinguishing biological developmental change from prior testing experience. We examined factors potentially influencing change scores on 16 neuropsychological test composites over 1year in 568 adolescents in the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) project. The twice-minus-once-tested method revealed that performance gain was mainly attributable to testing experience (practice) with little contribution from predicted developmental effects...
January 24, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28212849/hydrogen-sulfide-endoplasmic-reticulum-stress-and-alcohol-mediated-neurotoxicity
#12
REVIEW
Akash K George, Jyotirmaya Behera, Kimberly E Kelly, Yuankun Zhai, Neetu Tyagi
Alcohol is one of the most socially accepted addictive drugs in modern society. Its abuse affects virtually all organ systems with the central nervous system (CNS) being particularly vulnerable to excessive alcohol exposure. Alcohol exposure also causes profound damage to both the adult and developing brain. Excessive alcohol consumption induces numerous pathophysiological stress responses, one of which is the endoplasmic reticulum (ER) stress response. Potential mechanisms that trigger the alcohol induced ER stress response are either directly or indirectly related to alcohol metabolism, which include toxic levels of acetaldehyde and homocysteine, oxidative stress and abnormal epigenetic modifications...
February 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28212679/histopathological-study-of-cardiac-lesions-in-methamphetamine-poisoning-related-deaths
#13
Maryam Akhgari, Homeira Mobaraki, Afshar Etemadi-Aleagha
BACKGROUND: Methamphetamine abuse is a worldwide health concern. Methamphetamine causes health hazards in many vital organs. It can cause damage to cardiac tissue via catecholamines release. Methamphetamine related deaths are becoming one of the most important problems in Iran. The purpose of the present study was to determine cardiac pathology in methamphetamine poisoning-related deaths. METHODS: The study included 100 cases of methamphetamine poisoning-related deaths and 100 cases as control group...
February 17, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28212516/sex-disparities-in-substance-abuse-research-evaluating-23-years-of-structural-neuroimaging-studies
#14
Kimberly E Lind, Eric J Gutierrez, Dorothy J Yamamoto, Michael F Regner, Sherry A McKee, Jody Tanabe
BACKGROUND: Sex differences in brain structure and clinical course of substance use disorders underscores the need to include women in structural brain imaging studies. The NIH has supported the need for research to address sex differences. We evaluated female enrollment in substance abuse structural brain imaging research and the methods used to study sex differences in substance effects. METHODS: Structural brain imaging studies published through 2016 (n=230) were evaluated for number of participants by sex and substance use status and methods used to evaluate sex differences...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28211594/substance-dependence-among-those-without-symptoms-of-substance-abuse-in-the-world-mental-health-survey
#15
Luise Lago, Meyer D Glantz, Ronald C Kessler, Nancy A Sampson, Ali Al-Hamzawi, Silvia Florescu, Jacek Moskalewicz, Sam Murphy, Fernando Navarro-Mateu, Yolanda Torres de Galvis, Maria Carmen Viana, Miguel Xavier, Louisa Degenhardt
The World Health Organization (WHO) World Mental Health (WMH) Survey Initiative uses the Composite International Diagnostic Interview (CIDI). The first 13 surveys only assessed substance dependence among respondents with a history of substance abuse; later surveys also assessed substance dependence without symptoms of abuse. We compared results across the two sets of surveys to assess implications of the revised logic and develop an imputation model for missing values of lifetime dependence in the earlier surveys...
February 17, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28210782/toll-like-receptor-signaling-and-stages-of-addiction
#16
REVIEW
Fulton T Crews, T Jordan Walter, Leon G Coleman, Ryan P Vetreno
BACKGROUND: Athina Markou and her colleagues discovered persistent changes in adult behavior following adolescent exposure to ethanol or nicotine consistent with increased risk for developing addiction. Building on Dr. Markou's important work and that of others in the field, researchers at the Bowles Center for Alcohol Studies have found that persistent changes in behavior following adolescent stress or alcohol exposure may be linked to induction of immune signaling in brain. AIM: This study aims to illuminate the critical interrelationship of the innate immune system (e...
February 17, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28208210/heterogeneous-costs-of-alcohol-and-drug-problems-across-cities-and-counties-in-california
#17
Ted R Miller, Peter Nygaard, Andrew Gaidus, Joel W Grube, William R Ponicki, Bruce A Lawrence, Paul J Gruenewald
BACKGROUND: Estimates of economic and social costs related to alcohol and other drug (AOD) use and abuse are usually made at state and national levels. Ecological analyses demonstrate, however, that substantial variations exist in the incidence and prevalence of AOD use and problems including impaired driving, violence, and chronic disease between smaller geopolitical units like counties and cities. This study examines the ranges of these costs across counties and cities in California...
February 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28207998/benzodiazepine-and-z-drug-dependence-data-from-a-tertiary-care-center
#18
Lekhansh Shukla, Spandana Bokka, Tulika Shukla, Arun Kandasamy, Prabhat Chand, Vivek Benegal, Pratima Murthy
Objective: To examine the clinical characteristics and course of benzodiazepine and �Z-drug� dependence in patients presenting to a tertiary deaddiction center in southern India. Methods: Case files of 950 inpatients admitted between January 2007 and January 2014 who reported benzodiazepine or Z-drug use were reviewed. Patients (n = 170) with an ICD-10 diagnosis of mental and behavioral disorders due to the use of sedatives or hypnotics-dependence syndrome currently using substance (F13...
February 16, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28205146/binge-drinking-current-diagnostic-and-therapeutic-issues
#19
Benjamin Rolland, Mickaël Naassila
The concept of binge drinking (BD) refers to patterns of heavy episodic alcohol consumption, with BD primarily occurring among adolescents and young adults. Several official definitions of BD have been proposed, in particular by the World Health Organization, the National Institute on Alcoholism and Alcohol Abuse, and the Substance Abuse and Mental Health Services Administration. Nevertheless, none of these definitions address the psychosocial and medical consequences of the type of alcohol use seen in BD. In practice, BD can thus correspond to either hazardous or harmful use of alcohol (HUA), while the episodic nature of heavy drinking in BD means that it does not meet the criteria for 'alcohol dependence'...
February 15, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28202929/prohibition-of-e-cigarettes-in-the-us-are-prohibitions-where-alcohol-is-consumed-related-to-lower-alcohol-consumption
#20
Alexandra R Hershberger, Kenny A Karyadi, Melissa A Cyders
Recently, research has suggested negative consequences related to electronic cigarette (e-cig) use, including the increased risk for alcohol use and abuse. Previous work found that cigarette smoking ban legislation lowered overall smoking and alcohol use rates; however, researchers have not yet examined the potential effects of prohibiting e-cig use. The present study surveyed 617 individuals from a community-based online sample in the US (mean age = 33.33, SD = 10.50, 54.7 per cent female) who reported their smoking/e-cig use status, alcohol consumption, and the presence of e-cig prohibitions where they consume alcohol...
December 2016: Journal of Public Health Policy
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