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functional constipation

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https://www.readbyqxmd.com/read/28230565/outcomes-of-transvaginal-high-uterosacral-ligaments-suspension-over-500-patient-single-center-study
#1
Rodolfo Milani, Matteo Frigerio, Alice Cola, Carlo Beretta, Federico Spelzini, Stefano Manodoro
BACKGROUND: Uterosacral ligament (USL) suspension is a safe and effective procedure in terms of anatomical, functional, and subjective outcomes for primary surgical treatment of prolapse. OBJECTIVES: There has been a renewed interest toward native tissue prolapse repair by vaginal route because of low cost and lack of mesh-related complications. Uterosacral ligaments are considered safe, effective, and durable as suspending structures for primary surgical repair of the apical compartment...
February 23, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28226332/responsible-safe-and-effective-prescription-of-opioids-for-chronic-non-cancer-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#2
Laxmaiah Manchikanti, Adam M Kaye, Nebojsa Nick Knezevic, Heath McAnally, Konstantin Slavin, Andrea M Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S Grider, Alan D Kaye, Kavita N Manchikanti, Harold Cordner, Christopher G Gharibo, Michael E Harned, Sheri L Albers, Sairam Atluri, Steve M Aydin, Sanjay Bakshi, Robert L Barkin, Ramsin M Benyamin, Mark V Boswell, Ricardo M Buenaventura, Aaron K Calodney, David L Cedeno, Sukdeb Datta, Timothy R Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm Ii, Rafael Justiz, Dhanalakshmi Koyyalagunta, Yogesh Malla, Annu Navani, Kent H Nouri, Ramarao Pasupuleti, Nalini Sehgal, Sanford M Silverman, Thomas T Simopoulos, Vijay Singh, Daneshvari R Solanki, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Arthur Watanabe, Joshua A Hirsch
BACKGROUND: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28216670/intraluminal-pressure-patterns-in-the-human-colon-assessed-by-high-resolution-manometry
#3
Ji-Hong Chen, Yuanjie Yu, Zixian Yang, Wen-Zhen Yu, Wu Lan Chen, Hui Yu, Marie Jeong-Min Kim, Min Huang, Shiyun Tan, Hesheng Luo, Jianfeng Chen, Jiande D Z Chen, Jan D Huizinga
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215390/osteopathic-management-of-chronic-constipation-in-women-patients-results-of-a-pilot-study
#4
Aurélie Belvaux, Michel Bouchoucha, Robert Benamouzig
BACKGROUND AND AIMS: Constipation is a common problem in western countries. The aim of this pilot study was to determine the effectiveness of osteopathic manipulative treatment (OMT) for the treatment of constipated women with functional constipation (FC) or defeation disorders (DD). METHODS: Twenty-one constipated females referred to a tertiary center were recruited. A course of OMT, weekly for four weeks, was given. Clinical questionnaire, Bristol stool form scale and patients' subjective perception of constipation, bloating and abdominal pain, were recorded...
February 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28213593/randomised-double-blind-parallel-group-placebo-controlled-study-to-evaluate-the-analgesic-efficacy-and-safety-of-vvz-149-injections-for-postoperative-pain-following-laparoscopic-colorectal-surgery
#5
Srdjan S Nedeljkovic, Darin J Correll, Xiaodong Bao, Natacha Zamor, Jose L Zeballos, Yi Zhang, Mark J Young, Johanna Ledley, Jessica Sorace, Kristen Eng, Carlyle P Hamsher, Rajivan Maniam, Jonathan W Chin, Becky Tsui, Sunyoung Cho, Doo H Lee
INTRODUCTION: In spite of advances in understanding and technology, postoperative pain remains poorly treated for a significant number of patients. In colorectal surgery, the need for developing novel analgesics is especially important. Patients after bowel surgery are assessed for rapid return of bowel function and opioids worsen ileus, nausea and constipation. We describe a prospective, double-blind, parallel group, placebo-controlled randomised controlled trial testing the hypothesis that a novel analgesic drug, VVZ -149, is safe and effective in improving pain compared with providing opioid analgesia alone among adults undergoing laparoscopic colorectal surgery...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28203450/the-effect-of-probiotic-yogurt-on-constipation-in-pregnant-women-a-randomized-controlled-clinical-trial
#6
Mojgan Mirghafourvand, Aziz Homayouni Rad, Sakineh Mohammad Alizadeh Charandabi, Zahra Fardiazar, Kolsoum Shokri
BACKGROUND: Probiotics can alter the colonic microbiota and might improve bowel function. OBJECTIVES: The aim of this study was to evaluate the effect of the consumption of yogurt, enriched with Bifidobacterium and Lactobacillus 4.8 × 10(10) (CFU) on the symptoms of constipated pregnant women. MATERIALS AND METHODS: This triple-blind randomized controlled trial was conducted on 60 constipated pregnant women who were diagnosed by the ROME III criteria in Tabriz, Iran from December 2014 to July 2015...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28194667/three-dimensional-anorectal-manometry-enhances-diagnostic-gain-by-detecting-sphincter-defects-and-puborectalis-pressure
#7
Shreya Raja, Francis C Okeke, Ellen M Stein, Sameer Dhalla, Monica Nandwani, Kristle L Lynch, C Prakash Gyawali, John O Clarke
BACKGROUND: Constipation and fecal incontinence (FI) are common and are often evaluated with anorectal manometry. Three-dimensional high-resolution anorectal manometry (HRAM) is a promising technology; however, implementation has been limited by lack of metrics and unclear clinical utility. AIM: To investigate the diagnostic utility of 3D HRAM compared to 2D HRAM. METHODS: Three-dimensional HRAM studies performed from April 2012 to October 2013 were identified and re-interpreted by two blinded investigators examining 3D function...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28192733/prospective-long-term-results-complications-and-risk-factors-in-pelvic-organ-prolapse-treatment-with-vaginal-mesh
#8
Inés M Laso-García, Miguel A Rodríguez-Cabello, Miguel A Jiménez-Cidre, Andrea Orosa-Andrada, David Carracedo-Calvo, Luis López-Fando, Francisco J Burgos-Revilla
OBJECTIVE: To assess the long-term results and complications of pelvic organ prolapse treatment with transvaginal mesh. STUDY DESIGN: Prospective observational study of 75 women who underwent surgery between 2005 and 2008 by the same surgeon. 44 patients (58,7%) underwent concomitant treatment of stress urinary incontinence. Anatomical criterion for failure was prolapse grade >I in any compartment. Analysis of functional features consisted of an assessment of urinary, sexual, and defecation symptoms, and pelvic pain...
February 6, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28192648/mapping-of-brain-activations-to-rectal-balloon-distension-stimuli-in-male-patients-with-irritable-bowel-syndrome-using-functional-magnetic-resonance-imaging
#9
Anupam Guleria, Arun Karyampudi, Rajan Singh, Chunni L Khetrapal, Abhai Verma, Uday C Ghoshal, Dinesh Kumar
Background/Aims: Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among male. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared...
February 14, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28185025/constipation-pathophysiology-and-current-therapeutic-approaches
#10
Amol Sharma, Satish Rao
Chronic constipation is a common, persistent condition affecting many patients worldwide, presenting significant economic burden and resulting in substantial healthcare utilization. In addition to infrequent bowel movements, the definition of constipation includes excessive straining, a sense of incomplete evacuation, failed or lengthy attempts to defecate, use of digital manoeuvres for evacuation of stool, abdominal bloating, and hard consistency of stools. After excluding secondary causes of constipation, chronic idiopathic or primary constipation can be classified as functional defecation disorder, slow-transit constipation (STC), and constipation-predominant irritable bowel syndrome (IBS-C)...
February 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28177993/effects-of-hysterectomy-on-pelvic-floor-disorders-a-longitudinal-study
#11
Akin Firat Kocaay, Derya Oztuna, Filiz Akin Su, Atilla Halil Elhan, Mehmet Ayhan Kuzu
BACKGROUND: Hysterectomy might adversely affect pelvic floor functions and result in many different symptoms, such as urinary and anal incontinence, obstructed defecation, and constipation. OBJECTIVE: The aim of this prospective study was to evaluate the influence of hysterectomy on pelvic floor disorders. DESIGN: This was a prospective and longitudinal study. SETTINGS: The study was conducted at the Ankara University Department of Surgery and the Dr Zekai Tahir Burak Women's Health Research and Education Hospital between September 2008 and March 2011...
March 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28177172/a-single-center-prospective-double-blind-sham-controlled-randomized-study-of-the-effect-of-a-vibrating-capsule-on-colonic-transit-in-patients-with-chronic-constipation
#12
A D Nelson, M Camilleri, A Acosta, A Boldingh, I Busciglio, D Burton, M Ryks, A R Zinsmeister
BACKGROUND: In an open-label study of 26 patients with IBS-C and chronic constipation, treatment with a vibrating (VIBRANT) capsule twice a week for 7.5 weeks resulted in 88.5% responders. Effects on colonic transit are unclear. We aimed to compare effects of VIBRANT and sham capsule treatment on colonic transit in patients with functional constipation. METHODS: Patients with functional constipation (Rome III criteria) were randomized to VIBRANT or sham capsule treatment for 8 weeks and underwent scintigraphic colonic transit measurements during week 8...
February 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28176047/gastrointestinal-physiology-and-function
#13
Beverley Greenwood-Van Meerveld, Anthony C Johnson, David Grundy
The gastrointestinal (GI) system is responsible for the digestion and absorption of ingested food and liquids. Due to the complexity of the GI tract and the substantial volume of material that could be covered under the scope of GI physiology, this chapter briefly reviews the overall function of the GI tract, and discusses the major factors affecting GI physiology and function, including the intestinal microbiota, chronic stress, inflammation, and aging with a focus on the neural regulation of the GI tract and an emphasis on basic brain-gut interactions that serve to modulate the GI tract...
February 8, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28175941/-health-related-quality-of-life-after-mechanical-ventilation-in-the-intensive-care-unit
#14
D Schädler, L Kaiser, B Malchow, T Becher, G Elke, I Frerichs, T Küchler, N Weiler
BACKGROUND: It is unknown whether health related quality of life measured in German patients one year after mechanical ventilation in the intensive care unit is impaired or not. OBJECTIVES: The aim of this study was to assess health related quality of life one year after inclusion into a randomized controlled trial for weaning from mechanical ventilation with the help of a questionnaire that has never been used in critically ill patients and to investigate whether health related quality of life scores differ between the study population and a general German population...
February 7, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28169931/bowel-function-and-quality-of-life-after-transanal-endorectal-pull-through-for-hirschsprung-disease-controlled-outcomes-up-to-adulthood
#15
Malla I Neuvonen, Kristiina Kyrklund, Risto J Rintala, Mikko P Pakarinen
OBJECTIVE: The aim of this study was to define controlled outcomes up to adulthood for bowel function and quality of life (QoL) after transanal endorectal pull-through (TEPT) for Hirschsprung disease (HD). SUMMARY OF BACKGROUND DATA: Although TEPT is the surgical standard for HD, controlled long-term follow-up studies evaluating bowel function and QoL are lacking. METHODS: Patients aged ≥4 years operated for HD with TEPT between 1987 and 2011 answered detailed questionnaires on bowel function and QoL [Pediatric Quality of Life Inventory (PedsQL, age <18 yrs) or Gastrointestinal Quality of Life Index (GIQLI) and SF-36]...
March 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28160607/overlap-between-irritable-bowel-syndrome-and-functional-dyspepsia-including-subtype-analyses
#16
Yoon Jin Choi, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Yong Sung Kim, Dong Ho Lee, Hyun Chae Jung
BACKGROUND AND AIM: Coexistent gastrointestinal symptom profiles and prevalence or associated factors for the overlap between each functional dyspepsia (FD) and irritable bowel syndrome (IBS) group remain unclear. Thus, the aim of the present study was to evaluate the clinicodemographic features of FD, IBS, and IBS-FD overlap and assess the risk factors thereof, including subtype and genetic polymorphisms for IBS-FD. METHODS: Consecutive patients were enrolled from the outpatient Gastroenterology clinics of Bundang Seoul National University Hospitals in Korea...
February 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28157109/objective-colonic-dysfunction-is-far-more-prevalent-than-subjective-constipation-in-parkinson-s-disease-a-colon-transit-and-volume-study
#17
Karoline Knudsen, Tatyana D Fedorova, Anne C Bekker, Peter Iversen, Karen Østergaard, Klaus Krogh, Per Borghammer
BACKGROUND: Gastrointestinal function has received increased interest in the context of Parkinson's disease (PD). Constipation is among the most frequent non-motor symptoms, but our understanding of the underlying pathology is limited. Subjective constipation correlates poorly with objective markers. OBJECTIVE: The aims were to evaluate colonic transit time and volume in PD and to correlate these measures with subjective symptoms and gastric emptying. METHODS: Thirty-two PD patients and 26 controls were included...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28157108/the-prevalence-of-constipation-and-irritable-bowel-syndrome-in-parkinson-s-disease-patients-according-to-rome-iii-diagnostic-criteria
#18
Takayasu Mishima, Jiro Fukae, Shinsuke Fujioka, Kotoe Inoue, Yoshio Tsuboi
BACKGROUND: Gastrointestinal symptoms are one of the most common non-motor features of Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk of developing PD; however, the prevalence of IBS in PD patients has not been fully evaluated. Rome III criteria are widely assessed with a questionnaire to determine functional gastrointestinal disorders. OBJECTIVE: We assessed the prevalence of constipation and IBS in PD patients in our cohort using Rome III criteria...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28156639/determining-priority-symptoms-of-women-with-recurrent-ovarian-cancers-a-gynecologic-oncology-group-study
#19
Lari B Wenzel, Sandra Ward, Susan M Sereika, Robert P Edwards, Michael Spring, Catherine M Bender, Richard T Penson, Teresa Hagan
: 101 Background: The purpose of this study is to recommend a core set of priority symptoms to be assessed in research and clinical settings for women with recurrent ovarian cancers. METHODS: We used baseline data of 497 women with recurrent ovarian, fallopian, or primary peritoneal cancer participating in a symptom management randomized clinical trial (GOG-0259) to identify a core index of patient-reported priority symptoms. We used the Symptom Representation Questionnaire to assess priority rankings of 28 symptoms based on four criteria: (1) symptom prevalence, (2) patient-reported symptom severity, (3) percentage of women identifying each symptom as one of top three symptoms "I would like to get better control over", and (4) the association between symptom severity and functional wellbeing as measured by the Functional Assessment of Cancer Therapy - Ovarian...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28144215/functional-disorders-slow-transit-constipation
#20
REVIEW
John Tillou, Vitaliy Poylin
Constipation is a very common complaint, with slow-transit constipation (STC) accounting for a significant proportion of cases. Old age, female gender, psychiatric illness, and history of sexual abuse are all associated with STC. The exact cause of STC remains elusive; however, multiple immune and cellular changes have been demonstrated. Diagnosis requires evidence of slowed colonic transit which may be achieved via numerous modalities. While a variety of medical therapies exist, these are often met with limited success and a minority of patients ultimately require operative intervention...
February 2017: Clinics in Colon and Rectal Surgery
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