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https://www.readbyqxmd.com/read/28544036/stereospecific-winding-of-polycyclic-aromatic-hydrocarbons-into-trinacria-propellers
#1
Dario Mosca, Antoine Stopin, Nicola Demitri, Johan Wouters, Davide Bonifazi
The stereospecific trimerization of enantiomerically-pure binaphthols with hexakis(bromomethyl)benzene gives access in one step to enantiomerically-pure molecular propellers, in which three binaphthyl rings are held together through dioxecine rings. X-Ray diffraction analysis revealed that three out the six naphthyl moieties are folded in a (EF)3-type arrangement held by three intramolecular C-H…π interactions. This slips outward the three remaining naphthyl rings in a blade-like fashion, just like in three-folded propeller components...
May 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28541793/inhibition-of-secreted-aspartyl-proteinase-activity-in-biofilms-of-candida-species-by-mycogenic-silver-nanoparticles
#2
Sabahat Hamid, Shama Zainab, Rani Faryal, Naeem Ali, Iqra Sharafat
Candida species are pleomorphic, commensal fungi associated with candidiasis. The extracellular hydrolytic-secreted aspartyl proteinases are recognized as chief agents for pathogenesis of Candida species, involved in the degradation of proteins and adhesion during biofilm formation. This study aimed at exploring inhibitory effect of mycogenic silver nanoparticles (Ag NPs) against C. albicans and non-albicans' biofilm growth and aspartyl proteinase enzyme activity in-vitro. Biofilm forming, drug-resistant clinical isolates of C...
May 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28541489/respiratory-effects-and-systemic-stress-response-following-acute-acrolein-inhalation-in-rats
#3
Samantha J Snow, Marie A McGee, Andres Henriquez, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Urmila P Kodavanti
Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically-impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a non-obese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4h/day for 1 or 2 days...
May 24, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28541048/monoanionic-bis-pyrazolyl-methylborate-ph3b-ch-3-5-ch3-2pz-2-as-a-supporting-ligand-for-copper-i-ethylene-cis-2-butene-and-carbonyl-complexes
#4
Shawn G Ridlen, Naveen V Kulkarni, H V Rasika Dias
The monoanionic bidentate ligand [(Ph3B)CH(3,5-(CH3)2Pz)2)](-) has been prepared from lithium bis(pyrazolyl)methanide and triphenylborane. This useful new ligand is closely related to the well-established bis(pyrazolyl)borate and bis(pyrazolyl)methane ligands but has key differences to both analogues as well. The ethylene, cis-2-butene, and carbon monoxide adducts [(Ph3B)CH(3,5-(CH3)2Pz)2]Cu(L) (where L = C2H4, cis-CH3HC═CHCH3, and CO) have been prepared from [(Ph3B)CH(3,5-(CH3)2Pz)2)]Li(THF), copper(I) triflate, and the corresponding coligand...
May 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28541029/homochiral-mof-as-circular-dichroism-sensor-for-enantioselective-recognition-on-nature-and-chirality-of-unmodified-amino-acids
#5
Yan-Wu Zhao, Yan Wang, Xian-Ming Zhang
Self-assembly of zinc salt with rationally designed chiral ligand, (1R,2R)-2-(pyridine-4-yl carbamoyl) cyclohexanecarboxylic acid (RR-PCCH) generated 2D homochiral metal-organic framework [Zn(RR-PCCHC)2] (HMOF-1) that is composed of DNA-like right-handed double-helix structure. HMOF-1 shows high solvent and thermal stability and is also stable in neutral, weak acidic and weak basic aqueous solution. Emulsified HMOF-1 shows strong inherent circular dichroism (CD) signal in aqueous solution, which can show regular intensity change by induction of amino acids...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540659/neuroprotective-benefits-of-aerobic-exercise-and-organoselenium-dietary-supplementation-in-hippocampus-of-old-rats
#6
José L Cechella, Marlon R Leite, Simone Pinton, Gilson Zeni, Cristina W Nogueira
The progressive decline of neurological functions, such as learning and memory, is an unavoidable consequence of aging. Our previous work suggested that the combination of physical exercise and a diet supplemented with diphenyl diselenide improves age-related memory decline in rats. The present study investigated the effects of physical exercise and a diet supplemented with diphenyl diselenide on the levels of proteins involved in the hippocampal neuroprotection to figure out the mechanisms related to the beneficial effects of this intervention in aged rats...
May 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28540178/scanometry-as-microplate-reader-for-high-throughput-method-based-on-dpph-dry-reagent-for-antioxidant-assay
#7
Mochammad Amrun Hidayat, Aulia Fitri, Bambang Kuswandi
The stable chromogenic radical 1,1'-diphenyl-2-picrylhydrazyl (DPPH) solution was immobilized on the microwell plate as dry reagent to construct a simple antioxidant sensor. Then, a regular flatbed scanner was used as microplate reader to obtain analytical parameters for antioxidant assay using one-shot optical sensors as scanometry technique. Variables affecting the acquisition of the images were optimized and the analytical parameters are obtained from an area of the sensing zone inside microwell using the average luminosity of the sensing zone captured as the mean of red, green, and blue (RGB) value using ImageJ(®) program...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539964/preclinical-and-clinical-studies-demonstrate-that-the-proprietary-herbal-extract-da-5512-effectively-stimulates-hair-growth-and-promotes-hair-health
#8
Jae Young Yu, Biki Gupta, Hyoung Geun Park, Miwon Son, Joon-Ho Jun, Chul Soon Yong, Jeong Ah Kim, Jong Oh Kim
The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p < 0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28539748/rapid-development-and-validation-of-improved-reversed-phase-high-performance-liquid-chromatography-method-for-the-quantification-of-mangiferin-a-polyphenol-xanthone-glycoside-in-mangifera-indica
#9
P Naveen, H B Lingaraju, K Shyam Prasad
Mangiferin, a polyphenolic xanthone glycoside from Mangifera indica, is used as traditional medicine for the treatment of numerous diseases. The present study was aimed to develop and validate a reversed-phase high-performance liquid chromatography (RP-HPLC) method for the quantification of mangiferin from the bark extract of M. indica. RP-HPLC analysis was performed by isocratic elution with a low-pressure gradient using 0.1% formic acid: acetonitrile (87:13) as a mobile phase with a flow rate of 1.5 ml/min...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28538762/papillary-muscle-free-strain-in-patients-with-severe-degenerative-and-functional-mitral-regurgitation
#10
Alev Kılıcgedik, Gokhan Kahveci, Ahmet Seyfeddin Gurbuz, Can Yucel Karabay, Ahmet Guler, Suleyman Cagan Efe, Soe Moe Aung, Ugur Arslantas, Serdar Demir, Ibrahim Akin Izgi, Cevat Kirma
Fundamento: The role of papillary muscle function in severe mitral regurgitation with preserved and reduced left ventricular ejection fraction and the method of choice to evaluate PM have still been the subjects of controversy. Objectives: To evaluate and compare papillary muscle function in and between patients with severe degenerative and functional mitral regurgitation by using the free strain method. Methods: 64 patients with severe mitral regurgitation - 39 patients with degenerative mitral regurgitation (DMR group) and 25 patients with severe functional mitral regurgitation (FMR group) - and 30 control subjects (control group) were included in the study...
April 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28538686/amorphous-in-ga-zn-o-powder-with-high-gas-selectivity-towards-wide-range-concentration-of-c%C3%A2-h%C3%A2-oh
#11
Hongxiang Chen, Wei Jiang, Lianfeng Zhu, Youwei Yao
Amorphous indium gallium zinc oxide (a-IGZO) powder was prepared by typical solution-based process and post-annealing process. The sample was used as sensor for detecting C₂H₅OH, H₂, and CO. Gas-sensing performance was found to be highly sensitive to C₂H₅OH gas in a wide range of concentration (0.5-1250 ppm) with the response of 2.0 towards 0.5 ppm and 89.2 towards 1250 ppm. Obvious difference of response towards C₂H₅OH, H₂, and CO was found that the response e.g., was 33.20, 6.64, and 2.84 respectively at the concentration of 200 ppm...
May 24, 2017: Sensors
https://www.readbyqxmd.com/read/28537393/paramagnetic-properties-of-a-crystalline-iron-sulfur-protein-by-magic-angle-spinning-nmr-spectroscopy
#12
Andrea Bertarello, Tobias Schubeis, Carmelo Fuccio, Enrico Ravera, Marco Fragai, Giacomo Parigi, Lyndon Emsley, Guido Pintacuda, Claudio Luchinat
We present the first solid-state NMR study of an iron-sulfur protein. The combined use of very fast (60 kHz) magic-angle spinning and tailored radiofrequency irradiation schemes allows the detection and the assignment of most of the (1)H and (13)C resonances of the oxidized high-potential iron-sulfur protein I from Ectothiorhodospira halophila (EhHiPIP I), including those in residues coordinating the Fe4S4 cluster. For these residues, contact shifts as large as 100 and 400 ppm for (1)H and (13)C resonances, respectively, were observed, which represent the most shifted solid-state NMR signals ever measured in metalloproteins...
May 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28537079/green-water-dispersible-photoluminescent-on-off-on-probe-for-selective-detection-of-fluoride-ions
#13
Pallavi Singhal, Bal Govind Vats, Sanjay Kumar Jha, Suman Neogy
Considering the high toxicity and widespread availability of fluoride ion in different environmental matrices, it is imperative to design a probe for its detection. In view of this a selective fluorescent on-off-on probe based on carbon quantum dots (CQDs) and Eu3+ has been designed. We have synthesized water soluble carboxylic acid functionalized CQDs and monitored its interaction with Eu3+. On addition of Eu3+ ions luminescence quenching in CQDs emission was observed (switch-off). We investigate the reason for this luminescence quenching using time resolved emission and high resolution transmission electron microscopy (HRTEM) studies and observed that both electron transfer from CQDs to Eu3+ and aggregation of CQDs are responsible for luminescence quenching...
May 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28536912/multivariate-statistical-and-gis-based-approaches-for-toxic-metals-in-tropical-mangrove-ecosystem-southeast-coast-of-india
#14
Rajendran Rajaram, Arumugam Ganeshkumar, Shanmugam Vinothkumar, Sethu Rameshkumar
The heavy metal concentrations in water and sediment samples were investigated in the tropical Muthupet mangrove ecosystem, southeast coast of India. The results demonstrated that, ranges of metals in water comprise of Cd-0.05 to 3.72; Cu-0.5 to 4.43; Pb-6.31 to 17.87; Zn-0.0 to12.91 ppm and sediment comprises of Cd-0.06 to 0.57; Cu-4.46 to 20.59; Pb-2.90 to 21.35; Zn-4.41 to 39.18 ppm. In all the three sites, heavy metals in sediment exhibited significant higher concentrations compared to water, except Cd...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28536911/hydrological-connectivity-and-burkholderia-pseudomallei-prevalence-in-wetland-environments-investigating-rice-farming-community-s-risk-of-exposure-to-melioidosis-in-north-east-thailand
#15
C Joon Chuah, Esther K H Tan, Rasana W Sermswan, Alan D Ziegler
In our analysis of 136 water samples from wetland environments (rice paddies, natural wetland sites, man-made water bodies) in rural areas of North-East Thailand, Burkholderia pseudomallei was most prevalent in rice paddies (15 of the 30 positive sites). The high prevalence in the water of rice fields is indicative of the inherent vulnerability of farmers in rural agricultural areas in this area of Thailand and likely other locations in the tropics. Nearly all B. pseudomallei-positive sites were found within the vicinity of a large wetland associated with the Chi River, in the month of July 2014...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28535863/evaluation-of-anthelmintic-resistance-and-exhaust-air-dust-pcr-as-a-diagnostic-tool-in-mice-enzootically-infected-with-aspiculuris-tetraptera
#16
Pratibha Kapoor, Yumiko O Hayes, Leslie T Jarrell, Dwight A Bellinger, Rhiannon D Thomas, Gregory W Lawson, Jaclyn D Arkema, Craig A Fletcher, Judith N Nielsen
The entry of infectious agents in rodent colonies occurs despite robust sentinel monitoring programs, strict quarantine measures, and stringent biosecurity practices. In light of several outbreaks with Aspiculuris tetraptera in our facilities, we investigated the presence of anthelmintic resistance and the use of exhaust air dust (EAD) PCR for early detection of A. tetraptera infection. To determine anthelmintic resistance, C57BL/6, DBA/2, and NCr nude mice were experimentally inoculated with embryonated A...
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28535065/silica-polymerization-from-supersaturated-dilute-aqueous-solutions-in-the-presence-of-alkaline-earth-salts
#17
Marina Kley, Andreas Kempter, Volodymyr Boyko, Klaus Huber
The early stages of silica polymerization in aqueous solution proceeds according to a mechanism based on three steps: nucleation, particle growth and agglomeration of the particles. Application of time-resolved static and dynamic light scattering as a powerful in-situ technique in combination with spectrophotometric analysis of the monomer consumption based on the molybdenum blue method was carried out to further investigate this 3-step process. Experiments were carried out at four different initial silicic acid contents covering a range between 350 ppm and 750 ppm in the presence of either 10 mM NaCl or 5 mM of a mixture of CaCl2 and MgCl2...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28534679/laser-induced-photofragmentation-fluorescence-imaging-of-alkali-compounds-in-flames
#18
Tomas Leffler, Christian Brackmann, Marcus Aldén, Zhongshan Li
Laser-induced photofragmentation fluorescence has been investigated for the imaging of alkali compounds in premixed laminar methane-air flames. An ArF excimer laser, providing pulses of wavelength 193 nm, was used to photodissociate KCl, KOH, and NaCl molecules in the post-flame region and fluorescence from the excited atomic alkali fragment was detected. Fluorescence emission spectra showed distinct lines of the alkali atoms allowing for efficient background filtering. Temperature data from Rayleigh scattering measurements together with simulations of potassium chemistry presented in literature allowed for conclusions on the relative contributions of potassium species KOH and KCl to the detected signal...
June 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28534100/dose-dependent-differential-effects-of-in-vivo-exposure-of-cadmium-on-myometrial-activity-in-rats-involvement-of-vdcc-and-ca-2-mimicking-pathways
#19
Vivek K Saroj, Udayraj P Nakade, Abhishek Sharma, Soumen Choudhury, Sunil W Hajare, Satish K Garg
Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca(2+) levels in blood and uterus were measured by atomic absorption spectroscopy while isometric tension in myometrial strips was measured using data acquisition system-based physiograph. Dose-dependent increase in levels of cadmium was observed in both blood and uterus while calcium was increased only in the uterus as compared to those in control...
May 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28533327/serum-amyloid-a-an-ozone-induced-circulating-factor-with-potentially-important-functions-in-the-lung-brain-axis
#20
Michelle A Erickson, Joseph Jude, Hengjiang Zhao, Elizabeth M Rhea, Therese S Salameh, William Jester, Shelley Pu, Jenna Harrowitz, Ngan Nguyen, William A Banks, Reynold A Panettieri, Kelly L Jordan-Sciutto
Accumulating evidence suggests that O3 exposure may contribute to CNS dysfunction. Here, we posit that inflammatory and acute-phase proteins in the circulation increase after O3 exposure and systemically convey signals of O3 exposure to the CNS. To model acute O3 exposure, female Balb/c mice were exposed to 3 ppm O3 or forced air for 2 h and were studied after 6 or 24 h. Of 23 cytokines and chemokines, only KC/CXCL1 was increased in blood 6 h after O3 exposure. The acute-phase protein serum amyloid A (A-SAA) was significantly increased by 24 h, whereas C-reactive protein was unchanged...
May 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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