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Alok K Mishra, Shivraj M Yabaji, Rikesh K Dubey
Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets. Strikingly, the cytokines induced by Inos also play crucial roles in providing immune resistance against Mycobacterium tuberculosis (Mtb). Inos has been licensed for several antiviral diseases; however, its efficacy against Mtb has not been tested yet...
June 2018: Medical Hypotheses
Elitsa L Pavlova, Lora S Simeonova, Galina A Gegova
Influenza pathogenesis comprises a complex cascade of impaired cellular processes resulting from the viral replication and exaggerated immune response accompanied by reactive oxygen species (ROS) burst and oxidative stress, destructing membranous structures and tissues. By classical virological and biochemical methods we compared and evaluated the therapeutic effects of 2.5mg/kg/day of the antiviral drug - oseltamivir (OS), 500mg/kg/day of the immune modulator - isoprinosine (IP) and 500mg/kg/day of the antioxidant agent ellagic acid (EA) with a focus on their combined activities in influenza H3N2 virus-infected mice...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
O Janíčková, L Ančicová, K Briestenská, J Mistríková
We demonstrated the positive effect of Isoprinosine treatment on persistent infection of Balb/c mice with murine gammaherpesvirus 68 (MHV-68). Increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing (VN) antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. The positive effect of Isoprinosine therapy vanished after 120-150 days. After this interval, we demonstrated lower numbers of leukocytes, lower levels of VN antibodies and an increased number of atypical lymphoid monocytes in the Isoprinosine-treated group...
2017: Acta Virologica
Jiří Beran, Eva Šalapová, Marian Špajdel
BACKGROUND: Inosine pranobex (Isoprinosine®) is an immunomodulatory drug approved in several countries for the treatment of viral infections. This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. Subgroup analyses evaluated the efficacy of inosine pranobex compared to placebo in otherwise healthy (without related ongoing disease) subjects that were less than 50 years of age and healthy subjects that were at least 50 years of age...
November 7, 2016: BMC Infectious Diseases
Elitsa L Pavlova, Nikolay N Zografov, Lora S Simeonova
This study compares the antioxidant capacities in vitro of several synthetic and natural compounds applied and researched for influenza treatment - oseltamivir, isoprinosine, ellagic acid, vitamin E and vitamin C. Three chemical systems are utilized for the generation of reactive oxygen species (ROS) at pH 7.4 and pH 8.5: (1) Fenton's (Fe(2+)+H2O2) for OH and -OH species (2) H2O2 (3) NADH-phenazinemethosulfat, for superoxide radicals (O2(-)). The kinetics was evaluated by lucigenin-enhanced chemiluminescence...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
A A Breusov, E V Kulchavenya, E V Brizhatyukl, P N Filimonov
The review analyzed 59 sources of domestic and foreign literature on the use of immunomodulator izoprinozin in treating patients infected with human papilloma virus, and the results of their own experience. The high prevalence of HPV and its role in the development of cervical cancer are shown, the mechanisms of HPV development and the host protection from this infection are described. The authors present approaches to the treatment of HPV-infected patients with particular attention to izoprinozin. Isoprinosine belongs to immunomodulators with antiviral activity...
September 2015: Urologii︠a︡
Martin Häusler, Ayse Aksoy, Michael Alber, Sakir Altunbasak, Aydan Angay, Oana Tarta Arsene, Dana Craiu, Hans Hartmann, Semra Hiz-Kurul, Takashi Ichiyama, Catrinel Iliescu, Bosanka Jocic-Jakubi, Rudolf Korinthenberg, Gülsen Köse, Marissa B Lukban, Mehpare Ozkan, Iliyana Patcheva, Jens Teichler, Mihaela Vintan, Ahmet Yaramis, Coskun Yarar, Uluc Yis, Deniz Yuksel, Banu Anlar
Subacute sclerosing panencephalitis (SSPE) is a chronic infection of the central nervous system caused by the measles virus (MV). Its prevalence remains high in resource poor countries and is likely to increase in the Northern Europe as vaccination rates decrease. Clinical knowledge of this devastating condition, however, is limited. We therefore conducted this multinational survey summarizing experience obtained from more than 500 patients treated by 24 physicians in seven countries. SSPE should be considered in all patients presenting with otherwise unexplained acquired neurological symptoms...
December 2015: Neuropediatrics
B A Nejmark, Ju S Kondrat'eva, V S Zologina, D V Torbik
This study evaluates the effectiveness of immunomodulating drug isoprinosine in a comprehensive treatment of genital warts in men. Most of the patients were aged 20-30 years. The combination therapy was found to have long term effectiveness. In the group of patients undergoing only destructive methods of treatment relapse after 8 month follow-up was diagnosed in 32% and in patients of the combination therapy group (destruction plus isoprinosine) - in 7% of patients. The pharmacological action of the drug (immunostimulating, antiviral) and the effectiveness of its combination with destructive therapies justify the use of inosine pranobex (isoprinosine) both in the complex therapy of genital warts and for the prevention of the disease recurrence...
March 2015: Urologii︠a︡
M E Beth Smith, Elizabeth Haney, Marian McDonagh, Miranda Pappas, Monica Daeges, Ngoc Wasson, Rongwei Fu, Heidi D Nelson
BACKGROUND: Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a debilitating multisystem condition affecting more than 1 million adults in the United States. PURPOSE: To determine benefits and harms of treatments for adults with ME/CFS and identify future research needs. DATA SOURCES: MEDLINE, PsycINFO, and Cochrane databases (January 1988 to September 2014); clinical trial registries; reference lists; and manufacturer information...
June 16, 2015: Annals of Internal Medicine
Witold Lasek, Michał Janyst, Rafał Wolny, Łukasz Zapała, Katarzyna Bocian, Nadzieja Drela
Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a) or Th2 cells (IL-4, IL-5, and IL-10) were tested in human peripheral blood lymphocyte cultures stimulated with phytohemagglutinin (PHA). Inos enhanced TNF-a secretion significantly (in short-term--24-hour, and prolonged term--72-hour cultures) and IFN-g (in 72-hour cultures)...
June 2015: Acta Pharmaceutica
Arshad Rafique, Nida Amjad, Prem Chand, Syed Sohail Zahoor Zaidi, Muhammad Suleman Rana, Khalid Ahmed, Shahnaz Ibrahim
OBJECTIVE: To determine the clinical and demographic characteristics of children diagnosed with Subacute sclerosing panencephalitis (SSPE). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital, Karachi, from January 2000 to June 2012. METHODOLOGY: A retrospective analysis was done, regarding medical charts of 43 children under the age of 16 years with a discharge diagnosis of SSPE...
August 2014: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Takashi Ohya, Yushiro Yamashita, Ikuhiko Shibuya, Munetsugu Hara, Shinichiro Nagamitsu, Hayato Kaida, Seiji Kurata, Masatoshi Ishibashi, Toyojiro Matsuishi
We describe a 15-year-old girl with subacute sclerosing panencephalitis (SSPE) in stage II who was treated with isoprinosine, intraventricular interferon alpha (IFN-α), and ribavirin for 3 years. She is alive at three years from onset and studies at school with the assistance of a special educational teacher. To assess residual brain function, serial (18)FDG-positron emission tomography (PET) was performed three times to measure cortical metabolism: at onset, a year later, and three years later. At onset, PET study revealed preserved glucose metabolism of the cerebral cortex...
July 2014: European Journal of Paediatric Neurology: EJPN
I Ia Gospodarskiĭ, K V Volynets', V V Grushko, K O Gospodarskaia
Correlation between the presence of cryoglobulinemia and delayed convalescence in patients with acute viral hepatitis B and C has been studied. It is established that cryoglobulinaemia is more frequent in patients with long-term hepatitis C virus RNA replication (and anti-HCV IgM in the blood), than in cases where anti-HCV IgM disappeared from blood serum within the first month of antiviral treatment. The results of cycloferon, amixin, and isoprinosin administration in patients with acute viral hepatitis B and C have been analyzed...
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
Sandhya Ravikumar, John Ross Crawford
We describe the clinical presentation and clinical course of subacute sclerosing panencephalitis in a 13-year-old previously healthy boy who recently immigrated to the United States from Iraq. He presented with macular retinopathy, followed by progressive myoclonus and encephalopathy. After extensive workup, a diagnosis of subacute sclerosing panencephalitis was suspected by the presence of period epileptiform discharges on electroencephalogram and confirmed by elevated measles titers in the cerebrospinal fluid...
2013: Case Reports in Neurological Medicine
Ivan S Ivanov, Nikolay T Popov, Rumyana I Moshe, Elena V Chepisheva, Ina E Geneva, Margarita V Panova, Alexander A Karparov, Tonyo I Shmilev, Rumen S Stefanov, Miroslava N Bosheva
AIM: To study the development of children with selectively treated cytomegalovirus infection. PATIENTS AND METHODS: We studied prospectively a risk group of 12 children with cytomegalovirus infection. These children were diagnosed by serological screening in the first three months after birth and are defined as congenital and perinatal infections. Thirteen infants with no serological evidence of previous or present cytomegalovirus infection at 4-12 months of age were used as controls...
October 2012: Folia Medica
R Sh Iakupova, M A Skachkova, S B Choloian, E G Karpova
The authors evaluated the clinical efficacy and safety of the antiviral and immunomodulatory drug Isoprinosine (inosine pranobex, Teva Pharmaceutical Industries, Ltd) in the treatment of bronchopulmonary diseases in children. One hundred and fifty-two children with acute respiratory diseases and an exacerbation of recurrent respiratory diseases were followed up. The use of Isoprinosine in their combined treatment showed both positive clinical changes and a better immunogram.
May 2012: Gigiena i Sanitariia
Jia Li, Jing Li, Fengxia Liang, Yaqun Hong, Song Wu, Hongtu Tang, Hua Wang
Electroacupuncture (EA) therapy has been widely accepted as a useful therapeutic technique with low or no risk in the clinical prevention of cardiac hypertrophy. However, the signaling transduction mechanism underlying this effect remains unclear. The current study investigates the effects of EA on the signaling pathways of myocardial hypertrophy (MH) in rats. Up to 40 3-month-old Sprague-Dawley (SD) rats were randomly divided into normal, model, PC6 (Neiguan), and LI4 (Hegu) groups, with ten rats in each group...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
Burak Tatli, Bariş Ekici, Meral Ozmen
Subacute sclerosing panencephalitis (SSPE) is a progressive devastating disease. Along with the slow measles virus infection, apoptotic cell death has shown to be one of the major mechanisms at the pathogenesis. Volume reduction in frontotemporal cortex has seen in patients at early stages of disease. At present, there is no effective treatment to completely cure SSPE. Oral isoprinosine and intrathecal or intraventricular alpha-interferon are anti viral therapies with limited success. Flupirtine is an anti apoptotic agent which has been used with limited success in Alzheimer disease, prion diseases and neuronal ceroid lipofuscinosis which is a inherited disease of apoptosis related genes...
December 2010: Medical Hypotheses
Jose Gutierrez, Richard S Issacson, Barbara S Koppel
Subacute sclerosing panencephalitis (SSPE) is a chronic encephalitis occurring after infection with measles virus. The prevalence of the disease varies depending on uptake of measles vaccination, with the virus disproportionally affecting regions with low vaccination rates. The physiopathology of the disease is not fully understood; however, there is evidence that it involves factors that favour humoral over cellular immune response against the virus. As a result, the virus is able to infect the neurons and to survive in a latent form for years...
October 2010: Developmental Medicine and Child Neurology
Mihaela Petrova, Dejan Jelev, Aneta Ivanova, Zahariy Krastev
Isoprinosine is a synthetic purine derivative with immunomodulatory and antiviral properties, which result from an apparent in vivo enhancement of host immune responses. To evaluate the serum levels of certain cytokines during and after isoprinosine treatment, we assigned 10 healthy volunteers to receive isoprinosine 1 g, 3 times daily, 5 consecutive days weekly. Both treatment and follow-up phase last 3 weeks. Interferon-gamma (IFN-gamma), interleukin-2 (IL-2), IL-10, and tumor necrosis factor-alpha (TNF-alpha) were measured in serum using commercial ELISA kits at baseline, 7th, 10th, 14th, 21st, 28th, 35th, and 42nd day...
April 2010: Journal of Interferon & Cytokine Research
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