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guar gum

Jianfang Li, Chunjuan Wang, Die Hu, Fengjiao Yuan, Xueqing Li, Shihan Tang, Minchen Wu
A family 27 carbohydrate-binding module of a Thermotoga maritima β-mannanase (TmCBM27) was chosen from the carbohydrate-active enzyme database by computer-aided design, possessing the lowest binding free energy with mannopentaose. To improve the enzymatic properties of a glycoside hydrolase family 5 β-mannanase from Aspergillus usamii (AuMan5A), two fusion β-mannanases, AuMan5A-F-M and AuMan5A-R-M, were designed by fusing a TmCBM27 into its C-terminus linked with a flexible peptide F (GGGGS)3 and rigid peptide R (EAAAK)3...
October 20, 2016: Journal of Bioscience and Bioengineering
Do Young Kim, Chung Wook Chung, Han-Young Cho, Young Ha Rhee, Dong-Ha Shin, Kwang-Hee Son, Ho-Yong Park
OBJECTIVES: To evaluate the biocatalytic characteristics of a new endo-β-1,4-D-mannan-degrading enzyme (ManP) from Paenibacillus sp. strain HY-8, a gut bacterium of the longicorn beetle Moechotypa diphysis. RESULTS: Purified ManP (32 kDa) with an N-terminal amino acid sequence of APSFAVGADFSYVPG displayed the greatest degree of biocatalytic activity toward locust bean gum (LBG) at 55 °C and pH 7.0. The enzyme degraded LBG, guar gum, ivory nut mannan, and mannooligosaccharides (M2-M5), but did not exhibit any hydrolytic activity against structurally unrelated substrates...
October 6, 2016: Biotechnology Letters
Chengquan Tan, Hongkui Wei, Xichen Zhao, Chuanhui Xu, Yuanfei Zhou, Jian Peng
To understand whether soluble fiber (SF) with high water-binding capacity (WBC), swelling capacity (SC) and fermentability reduces food intake and whether it does so by promoting satiety or satiation or both, we investigated the effects of different SFs with these properties on the food intake in rats. Thirty-two male Sprague-Dawley rats were randomized to four equal groups and fed the control diet or diet containing 2% konjac flour (KF), pregelatinized waxy maize starch (PWMS) plus guar gum (PG), and PWMS starch plus xanthan gum (PX) for three weeks, with the measured values of SF, WBC, and SC in the four diets following the order of PG > KF > PX > control...
October 2, 2016: Nutrients
Cristina Eslava-Zomeño, Amparo Quiles, Isabel Hernando
The fat in a sponge cake formulation was partially replaced (0%, 30%, 50%, and 70%) with OptiSol™5300.This natural functional ingredient derived from flax seeds, rich in fiber and alpha-linoleic acid, provides a natural substitute for guar and xanthan gums, avoiding E-numbers on labels. The structure and some physicochemical properties of the formulations were examined, sensory analysis was conducted and changes in starch digestibility due to adding this ingredient were determined. Increasing quantities of OptiSol™5300 gave harder cakes, with less weight loss during baking, without affecting the final cake height...
October 2016: Journal of Food Science
Debparna Datta, Gottfried Pohlentz, Mona Schulte, Mathias Kaiser, Francisco M Goycoolea, Johannes Müthing, Michael Mormann, Musti J Swamy
An α-D-galactose specific lectin belonging to the family of jacalin-related lectins (JRL) has been purified by affinity chromatography on cross-linked guar-gum. Mass spectrometric data revealed that the protein harbors two chains like all the members of galactose-specific jacalin-related lectins (gJRL). De novo sequencing of proteolytic peptides demonstrated that the heavier chain consists of 133 amino acids and the lighter chain comprises of 21 or 24 amino acids. The heavier chain contains one N-glycosylation site (Asn47) occupied with either pauci-mannose type [GlcNAc2(Fuc)Man3(Xyl)] or complex type [GlcNAc2(Fuc)Man3(Xyl)GlcNAc(Fuc)Gal] N-glycans...
November 1, 2016: Archives of Biochemistry and Biophysics
Violet Kasabri, Entisar K Al-Hallaq, Yasser K Bustanji, Khalid K Abdul-Razzak, Ismail F Abaza, Fatma U Afifi
CONTEXT: Adiantum capillus-veneris L. (Adiantaceae) hypocholesterolemic activity is therapeutically praised. OBJECTIVES: Pharmacological modulation of pancreatic triacylglycerol lipase (PL) and α-amylase/α-glucosidase by A. capillus-veneris are evaluated. MATERIALS AND METHODS: Using positive controls (acarbose, orlistat, guar gum, atorvastatin, glipizide and metformin) as appropriate, crude aqueous extracts (AEs) of A. capillus-veneris aerial parts were tested via a combination of in vitro enzymatic (0...
September 23, 2016: Pharmaceutical Biology
Vegesna Naga Sravan Kumar Varma, Hosakote Gurumalappa Shivakumar, Veerna Balamuralidhara, Manne Navya, Umme Hani
The aim of the research work was to chemically modify guargum (GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-polymer. The effect of GG and acryl amide (AAm) on grafting was studied. Esomeprazole magnesium (ESO) loaded pH sensitive NPs were prepared by nano-emulsification polymer crosslinking method and characterized...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Umme Hani, H G Shivakumar, Riyaz Ali M Osmani, Atul Srivastava, Naga Sravan Kumar Varma
The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesive polymers like xanthan gum, guar gum and HPMC. Curcumin tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion, In-vitro release and antifungal activity...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Anjum Nawab, Feroz Alam, Muhammad Abdul Haq, Abid Hasnain
The effects of different concentrations of guar and xanthan gums on functional properties of mango kernel starch (MKS) were studied. Both guar and xanthan gum enhanced the water absorption of MKS. The addition of xanthan gum appeared to reduce the SP (swelling power) and solubility at higher temperatures while guar gum significantly enhanced the SP as well as solubility of MKS. The addition of both gums produced a reinforcing effect on peak viscosity of MKS as compared to control. Pasting temperature of MKS was higher than that of starch modified by gums indicating ease of gelatinization...
September 5, 2016: International Journal of Biological Macromolecules
Tran Van Hung, Takuya Suzuki
BACKGROUND: Dietary fiber (DF) and its fermentation metabolites play an important role in establishing and maintaining intestinal health. OBJECTIVE: This study investigated the effects of fermentable DF, guar gum (GG), and partially hydrolyzed GG (PHGG) on the epithelial tight junction (TJ) barrier and inflammation in a murine model of dextran sodium sulfate (DSS)-induced colitis. METHODS: In Expt. 1, male, 7-wk-old BALB/c mice weighing ∼21 g were fed diets with 0%, 5%, and 10% GG for 12 d and administered distilled water with 2% DSS for 7 d beginning 5 d after the start of feeding...
October 2016: Journal of Nutrition
Tomohisa Takagi, Yuji Naito, Yasuki Higashimura, Chihiro Ushiroda, Katsura Mizushima, Yuji Ohashi, Zenta Yasukawa, Makoto Ozeki, Makoto Tokunaga, Tsutomu Okubo, Kazuhiro Katada, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Yoshito Itoh, Toshikazu Yoshikawa
Partially hydrolysed guar gum (PHGG), a water-soluble dietary fibre produced by the controlled partial enzymatic hydrolysis of guar gum beans, has various physiological roles. This study aimed to elucidate the beneficial effects of PHGG on colonic mucosal damage in a murine 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Acute colitis was induced in male C57BL/6 mice with TNBS after 2 weeks of pre-feeding with PHGG (5 %). The colonic mucosal inflammation was evaluated using macroscopic damage scores, and neutrophil infiltration was assessed by measuring tissue-associated myeloperoxidase (MPO) activity in the colonic mucosa...
October 2016: British Journal of Nutrition
Justin Carlson, Trevor Gould, Joanne Slavin
BACKGROUND: Prebiotic dietary fibers resist digestion in the upper gastrointestinal tract and allow for stimulation of bacteria in the distal intestine and colon. Stimulation of bacteria among different individuals varies greatly, depending on a wide range of variables. OBJECTIVE: To determine the range of differences in response between individuals, a preclinical in vitro fermentation was conducted with six fecal donors. The primary objective was to compare the fecal microbiota of six individuals at baseline, 12 h and 24 h post-exposure to partially hydrolyzed guar gum (PHGG)...
August 30, 2016: Anaerobe
Deepak Mudgil, Sheweta Barak, B S Khatkar
Partially hydrolyzed guar gum was prepared using enzymatic hydrolysis of native guar gum that can be utilized as soluble fiber source. The effect of partially hydrolyzed guar gum (PHGG) on pasting, thermo-mechanical and rheological properties of wheat flour was investigated using rapid visco-analyzer, Mixolab and Microdoughlab. Wheat flour was replaced with 1-5g PHGG per 100g of wheat flour on weight basis. PHGG addition decreased the peak, trough, breakdown, setback and final viscosity of wheat flour. Water absorption and amylase activity of wheat dough were increased whereas starch gelatinization and protein weakening of wheat dough were reduced as a result of PHGG addition to wheat flour...
August 24, 2016: International Journal of Biological Macromolecules
Piyali Jana, Tapas Mitra, Thirupathi Kumara Raja Selvaraj, A Gnanamani, P P Kundu
Present study describes the synthesis of carboxymethyl guar gum (CMGG) from the native guar gum (GG) and the prepared CMGG is grafted with ethylenediamine (EDA) to form aminated CMGG. Then, fish scale collagen and aminated CMGG are cross-linked by ceftazidime drug through non- covalent ionic interaction. The resultant cross-linked film is subjected to the analysis of (1)HNMR, ATR-FTIR, TGA, SEM and XRD. The TNBS results revealed that 45% of interaction between EDA and CMGG and 90-95% of Ceftazidime is released from aminated CMGG-Ceftazidime-Collagen (ACCC) film after 96h of incubation at physiological pH...
November 20, 2016: Carbohydrate Polymers
Daniel Szopinski, Gerrit A Luinstra
The industrial relevant nonlinear viscoelastic properties of aqueous carboxymethyl hydroxypropyl guar gum (CMHPG) and non-ionic hydroxypropyl guar gum (HPG) solutions between semi-dilute and concentrated solution state were investigated by large amplitude oscillatory shear flow (LAOS). Aqueous CMHPG and HPG solutions enter the nonlinear flow regime at deformations γ0>100%. The nonlinear stress waveforms were analyzed by FT-rheology and orthogonal stress decomposition along the MITlaos framework. A rheological fingerprint is generated (Pipkin space) showing that the guar gum derivative solutions undergo a shear-thinning at high strains, which is preceded by a thickening above a minimum strain rate at intermediate strains...
November 20, 2016: Carbohydrate Polymers
Morris Gordon, John K MacDonald, Claire E Parker, Anthony K Akobeng, Adrian G Thomas
BACKGROUND: Constipation within childhood is an extremely common problem. Despite the widespread use of osmotic and stimulant laxatives by health professionals to manage constipation in children, there has been a long standing paucity of high quality evidence to support this practice. OBJECTIVES: We set out to evaluate the efficacy and safety of osmotic and stimulant laxatives used to treat functional childhood constipation. SEARCH METHODS: We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane IBD Group Specialized Trials Register from inception to 10 March 2016...
2016: Cochrane Database of Systematic Reviews
Judith Piermaría, Carlos Bengoechea, Analía Graciela Abraham, Antonio Guerrero
Kefiran is a neutral polysaccharide constituted by glucose and galactose produced by Lactobacillus kefiranofaciens. It is included into kefir grains and has several health promoting properties. In the present work, shear and extensional properties of different kefiran aqueous dispersions (0.5, 1 and 2% wt.) were assessed and compared to other neutral gums commonly used in food, cosmetic and pharmaceutics industries (methylcellulose, locust bean gum and guar gum). Kefiran showed shear flow characteristics similar to that displayed by other representative neutral gums, although it always yielded lower viscosities at a given concentration...
November 5, 2016: Carbohydrate Polymers
Raquel Santos, Diana Gomes, Hermes Macedo, Diogo Barros, Catarina Tibério, Ana Salomé Veiga, Luís Tavares, Miguel Castanho, Manuela Oliveira
Diabetic patients frequently develop diabetic foot ulcer (DFU), particularly vulnerable to Staphylococcus aureus opportunistic infections. It is urgent to find new treatments for bacterial infections. The antimicrobial peptide (AMP) nisin is a potential candidate, mainly due to its broad spectrum of action against pathogens. Considering that AMP can be degraded or inactivated before reaching their target at therapeutic concentrations, it is mandatory to establish effective AMP delivery systems, being the natural polysaccharide guar gum one of the most promising...
August 5, 2016: Journal of Medical Microbiology
John Bradley Morris, Ming Li Wang
Dry guar (Cyamopsis tetragonoloba L. Taub) seeds are primarily used to extract galactomannan gum for oil fracking, however, the immature pods are used as a vegetable in India and sold in ethnic grocery stores in the Atlanta, Georgia area. Nineteen guar genotypes were grown in the field at Griffin, GA, USA for two years (2010-2011). Since the determination of flavonoid concentration would add value to the guar accessions for use as a functional food vegetable, immature guar pods were evaluated for flavonoid concentration...
August 2, 2016: Journal of Dietary Supplements
Md Lutful Amin, Tajnin Ahmed, Md Abdul Mannan
PURPOSE: The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS: Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release modifier. Carbopol was used for increasing the bead strength. The microspheres were characterized by scanning electron microscopy and evaluated by means of drug entrapment efficiency, in vitro buoyancy, and swelling studies...
June 2016: Advanced Pharmaceutical Bulletin
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