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https://www.readbyqxmd.com/read/29219056/in-vitro-and-in-vivo-pharmacokinetic-evaluation-of-guar-gum-eudragit%C3%A2-s100-based-colon-targeted-spheroids-of-sulfasalazine-co-administered-with-probiotics
#1
Abhinav Sharma, Bimlesh Kumar, Sachin Kumar Singh, Monica Gulati, Yogyata Vaidya, Manik Sadotra, Harish Rathee, Deepak Ghai, Adil Hussain Malik, Ankit Kumar Yadav, Peddi Maharshi, Palak Bawa, Sarvi Yadav Rajesh, Parth Sharma, Narendra Kumar Pandey, Souvik Mohant
Polysaccharide based delivery systems have been successfully used to target drugs to colon. In some recent reports, the superiority of concomitant administration of probiotics with such systems has been established. However, the pharmacokinetics of such symbiotic therapy remain unexplored hitherto. This study deciphers the pharmacokinetic parameters of guar gum based colon targeted spheroids of sulfasalazine with co-administration of probiotics in experimental rats. Thirty rats were divided into five groups using Latin square design...
December 7, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29217184/formulation-of-novel-chitosan-guargum-based-hydrogels-for-sustained-drug-release-of-paracetamol
#2
Amtul Jamil Sami, Madeeha Khalid, Tahir Jamil, Saira Aftab, Sermad Ahmad Mangat, A R Shakoori, S Iqbal
The report presents the formulation of hydrogel based on biopolymers chitosan and guar gum after cross-linking for sustained release of a commonly used orally prescribed analgesic Paracetamol. The oral ingestion of Paracetamol is associated with complications of the gastric tract and liver metabolism that can be effectually avoided by using transdermal drug delivery systems. The formulated transdermal patch was characterized by physicochemical properties including swelling, bonding pattern (using FTIR Fourier Transform Infra-Red and Scanning Electron Microscopy SEM) and antimicrobial activity...
December 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29191419/application-of-guar-gum-in-brine-clarification-and-oily-water-treatment
#3
Marcus Vinicius Gomes Paixão, Rosangela de Carvalho Balaban
The increasing amount of oil wastewater is causing serious damage to the environment. Oily water is a worrisome by-product of the oil industry due to its growing volume in mature basins and complex chemical composition. Low-cost polymers are being used as alternative materials to treat oily waters after treatment by conventional methods, oil and grease (O&G) concentration being the primary parameter for final disposal. In this respect, guar gum can be used to treat petroleum-contaminated waters, with the advantage of being a low-cost, highly-hydrophilic natural polymer...
November 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29188765/cross-linked-guar-gum-and-sodium-borate-based-microspheres-as-colon-targeted-anticancer-drug-delivery-systems-for-5-fluorouracil
#4
Tehsin Kamal, Muhammad Sarfraz, Mosab Arafat, Momir Mikov, Nisarur Rahman
The aim was to prepare cross linked polymer of 5-fluorouracil loaded microspheres containing guar gum and sodium borate for colon-targeted drug delivery systems. Micro spheres were prepared using emulsification cross linking method. The influence of drug polymer ratio, cross linker agent concentrations and cross linking timing on in vitro drug release and characteristics in terms of drug loading, entrapment efficiency and yielding percentage were investigated. The optimum drug loading, entrapment efficiency and percent yield were obtained from formulations with the lowest content of cross linker agent over 2 h of cross linking timing but with the highest drug to polymer ratio 1:11...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29174355/a-novel-inhibition-based-biosensor-using-urease-nanoconjugate-entrapped-biocomposite-membrane-for-potentiometric-glyphosate-detection
#5
Chetana Vaghela, Mohan Kulkarni, Santosh Haram, Rohini Aiyer, Meena Karve
A potentiometric biosensor based on agarose-guar gum (A-G) entrapped bio-nanoconjugate of urease with gold nanoparticles (AUNps), has been reported for the first time for glyphosate detection. The biosensor is based on inhibition of urease activity by glyphosate, which was measured by direct potentiometry using ammonium ion selective electrode covered with A-G-urease nanoconjugate membrane. TEM and FTIR analysis revealed nanoconjugate formation and its immobilization in A-G matrix respectively. The composite biopolymer employed for immobilization yields thin, transparent, flexible membrane having superior mechanical strength and stability...
November 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29153856/the-effect-of-viscous-soluble-fiber-on-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
K Khan, E Jovanovski, H V T Ho, A C R Marques, A Zurbau, S B Mejia, J L Sievenpiper, V Vuksan
AIMS: Dietary fiber intake, especially viscous soluble fiber, has been established as a means to reduce cardiometabolic risk factors. Whether this is true for blood pressure remains controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of viscous soluble fiber supplementation on blood pressure and quantify the effect of individual fibers. DATA SYNTHESIS: MEDLINE, Embase, and Cochrane databases were searched...
October 7, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29121338/efficacy-of-%C3%AE-mannanase-on-broiler-growth-performance-and-energy-utilization-in-the-presence-of-increasing-dietary-galactomannan
#7
R E Latham, M P Williams, H G Walters, B Carter, J T Lee
An experiment was conducted to investigate the impact of β-mannanase inclusion on growth performance, viscosity, and energy utilization in broilers fed diets varying in galactomannan (GM) concentrations. Treatments were arranged as a 3 (GM concentration) × 3 (β-mannanase inclusion) factorial randomized complete block design with 12 replicates of 29 male broilers per replicate for a 42-d experiment. Efforts were made to reduce the amount of soybean meal, and thus GM, in the basal diet with guar gum included at 0, 0...
November 7, 2017: Poultry Science
https://www.readbyqxmd.com/read/29120386/high-quality-unigenes-and-microsatellite-markers-from-tissue-specific-transcriptome-and-development-of-a-database-in-clusterbean-cyamopsis-tetragonoloba-l-taub
#8
Hukam C Rawal, Shrawan Kumar, Amitha Mithra S V, Amolkumar U Solanke, Deepti Nigam, Swati Saxena, Anshika Tyagi, Sureshkumar V, Neelam R Yadav, Pritam Kalia, Narendra Pratap Singh, Nagendra Kumar Singh, Tilak Raj Sharma, Kishor Gaikwad
Clusterbean (Cyamopsis tetragonoloba L. Taub), is an important industrial, vegetable and forage crop. This crop owes its commercial importance to the presence of guar gum (galactomannans) in its endosperm which is used as a lubricant in a range of industries. Despite its relevance to agriculture and industry, genomic resources available in this crop are limited. Therefore, the present study was undertaken to generate RNA-Seq based transcriptome from leaf, shoot, and flower tissues. A total of 145 million high quality Illumina reads were assembled using Trinity into 127,706 transcripts and 48,007 non-redundant high quality (HQ) unigenes...
November 9, 2017: Genes
https://www.readbyqxmd.com/read/29111067/gums-induced-microstructure-stability-in-ca-ii-alginate-beads-containing-lactase-analyzed-by-saxs
#9
Maria Victoria Traffano-Schiffo, Marta Castro-Giraldez, Pedro J Fito, Mercedes Perullini, Patricio R Santagapita
Previous works show that the addition of trehalose and gums in β-galactosidase (lactase) Ca(II)-alginate encapsulation systems improved its intrinsic stability against freezing and dehydration processes in the pristine state. However, there is no available information on the evolution in microstructure due to the constraints imposed by the operational conditions. The aim of this research is to study the time course of microstructural changes of Ca(II)-alginate matrices driven by the presence of trehalose, arabic and guar gums as excipients and to discuss how these changes influence the diffusional transport (assessed by LF-NMR) and the enzymatic activity of the encapsulated lactase...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29111056/optimization-of-tenofovir-release-from-mucoadhesive-vaginal-tablets-by-polymer-combination-to-prevent-sexual-transmission-of-hiv
#10
Fernando Notario-Pérez, Raúl Cazorla-Luna, Araceli Martín-Illana, Roberto Ruiz-Caro, Aitana Tamayo, Juan Rubio, María-Dolores Veiga
The use of sustained-release mucoadhesive vaginal tablets of antiretroviral drugs as microbicidal formulations can be an effective strategy for reducing the sexual transmission of HIV from men to women, which is a main problem particularly in low- and middle-income countries. Different polymers (hydroxypropylmethyl cellulose (HPMC), chitosan, guar gum and Eudragit(®) RS) have proven some good features for this purpose. At this work, these polymers have been combined in pairs in different proportions to enhance the advantages offered by each one individually...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29111044/structural-and-physicochemical-changes-in-guar-gum-by-alcohol-acid-treatment
#11
Dandan Li, Na Yang, Yao Zhang, Lunan Guo, Shangyuan Sang, Zhengyu Jin, Xueming Xu
The aim of this study was to evaluate the effects of alcohol-acid degradation on the structural and physicochemical characteristics of guar gum. Guar gum (50wt.%) was treated with methanol, ethanol, 2-propanol, or 1-butanol containing 1 or 2mL 36% hydrochloric acid at 75°C for 30-240min. The linear relationship between 1/Mw and time suggested that alcohol-acid degradation followed first-order kinetics with rate constants varying directly with the number of alcohol carbon atoms and acid concentration. Alcohol-acid treatment exerted no effect on the chemical and crystal structure of guar but significantly decreased shear viscosity, slightly increased solubility, mildly reduced thermostability, and dramatically darkened colour...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29110741/effect-of-fibre-additions-to-flatbread-flour-mixes-on-glucose-kinetics-a-randomised-controlled-trial
#12
Hanny M Boers, Theo H van Dijk, Harry Hiemstra, Anne-Roos Hoogenraad, David J Mela, Harry P F Peters, Roel J Vonk, Marion G Priebe
We previously found that guar gum (GG) and chickpea flour (CPF) added to flatbread wheat flour lowered postprandial blood glucose (PPG) and insulin responses dose dependently. However, rates of glucose influx cannot be determined from PPG, which integrates rates of influx, tissue disposal and hepatic glucose production. The objective was to quantify rates of glucose influx and related fluxes as contributors to changes in PPG with GG and CPF additions to wheat-based flatbreads. In a randomised cross-over design, twelve healthy males consumed each of three different 13C-enriched meals: control flatbreads (C), or C incorporating 15 % CPF with either 2 % (GG2) or 4 % (GG4) GG...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29103525/extraction-purification-and-characterization-of-galactomannan-from-fenugreek-for-industrial-utilization
#13
Farhat Rashid, Sarfraz Hussain, Zaheer Ahmed
Galactomannan, a water-soluble heteropolysaccharide was isolated and purified from seed of fenugreek locally called as Kasuri Methi. Polysaccharide was chemically characterized and its functional attributes were studied in detail. FTIR analysis divulges representative peaks of polysaccharide in region of 3324, 2914 & 1653cm(-1). Galactomannan depicted lower water holding capacity compared to guar gum. Emulsifying activity and emulsion stability of biopolymer was on higher side as compare to reference material...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29084137/kiwifruit-non-sugar-components-reduce-glycaemic-response-to-co-ingested-cereal-in-humans
#14
Suman Mishra, Haley Edwards, Duncan Hedderley, John Podd, John Monro
Kiwifruit (KF) effects on the human glycaemic response to co-ingested wheat cereal were determined. Participants (n = 20) consumed four meals in random order, all being made to 40 g of the same available carbohydrate, by adding kiwifruit sugars (KF sug; glucose, fructose, sucrose 2:2:1) to meals not containing KF. The meals were flaked wheat biscuit (WB)+KFsug, WB+KF, WB+guar gum+KFsug, WB+guar gum+KF, that was ingested after fasting overnight. Blood glucose was monitored 3 h and hunger measured at 180 min post-meal using a visual analogue scale...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29078182/tungsten-vi-based-molecular-puzzle-photoluminescent-nanoparticles-easily-covered-with-biocompatible-natural-polysaccharides-via-direct-chelation
#15
Volodymyr Lobaz, Martin Hladik, Miloš Steinhart, Aleksandra Paruzel, Peter Černoch, Jiří Pánek, Miroslav Vetrík, Daniel Jirák, Markéta Jirátová, Ognen Pop-Georgievski, Miroslav Šlouf, Sébastien Garcia-Argote, Gregory Pieters, Eric Doris, Martin Hrubý
Multimodal probes, which can be simultaneously visualized by multiple imaging modalities, enable the cellular uptake, intracellular fate, biodistribution and elimination to be tracked in organisms. In this study, we report the synthesis of crystalline WO3 and CaWO4 doped with Eu(3+) or Tb(3+) nanoparticles (size range of 10-160 nm) coated with polysaccharides, and these nanoparticles constitute a versatile easy-to-construct modular toolbox for multimodal imaging. The particles adsorb significant amounts of polysaccharides from the solution, providing biocompatibility and may serve as a platform for labeling...
October 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29056467/gold-laced-bio-macromolecules-for-theranostic-application
#16
REVIEW
Pranjali Yadav, Surya Prakash Singh, Aravind Kumar Rengan, Asifkhan Shanavas, Rohit Srivastava
Gold nanostructures are promising entities for various biomedical applications, due to their promising physical and optical properties. They can be tailored in different sizes and shapes to play vital roles for photothermal therapy, Biosensing, In vivo X-ray/CT contrast etc. Many biomacromolecules have been used for chemical reduction of ionic gold into zero-valent metallic nanoparticles of specific shape/size followed by stabilizing them for long term utilization. This review will sum up a range of biomacromolecules including Alginate, Agarose, Starch, Carragenan, Cellulose, Chitin, Chitosan, Collagen, Cyclodextrins, Chondrotin Sulfate, Dextran Sulfate, Fucoidan, Gelatin, Guar Gum and Hyaluronic Acid, whose functionalities have been explored in combination with gold nanoparticles for various biomedical applications...
October 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28967223/human-capability-in-the-perception-of-extensional-and-shear-viscosity
#17
Zhihong Lv, Jianshe Chen, Melvin Holmes
Shear and extensional deformation are two basic rheological phenomena which occur commonly in our daily life. Because of the very different nature of the two deformations, fluid materials may exhibit significant differences in their responses to shear and extensional forces. This work investigated the human perception of shear and extensional viscosity and tested the hypothesis that human have different discriminatory sensation mechanisms including scaling to the two deformations. A series of fluid samples were prepared using two common food thickeners, guar gum and sodium carboxylmethylcellulose (CMC-Na)...
October 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28962753/adsorption-of-soluble-pb-ii-by-a-photocrosslinked-polysaccharide-hybrid-a-swelling-adsorption-correlation-study
#18
Abhijit Pal, Kunal Majumder, Srijoni Sengupta, Tamalika Das, Abhijit Bandyopadhyay
A biosorbent for adsorption of soluble, inorganic Pb(II) was prepared through a photocrosslinking of a mixture of xanthan gum and guar gum at various mass ratios. The polysaccharide mixes were irradiated using UV A in presence of benzophenone. Chemical crosslinks were formed which led to a controlled swelling of the polysaccharide mix (swelling ratio <20%), referred as crosslinked hybrid in the text. The hybrids were characterized for microstructure, rheology, surface area and surface charge behavior. Interesting changes in crystallographic pattern, both in the pre and the post adsorption stages, was investigated using x-ray diffraction technique...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28946395/a-simple-approach-for-the-sonochemical-synthesis-of-fe3o4-guargum-nanocomposite-and-its-catalytic-reduction-of-p-nitroaniline
#19
Jayachandrabal Balachandramohan, Sambandam Anandan, Thirugnanasambandam Sivasankar
In this present study, a facile and green method to synthesize highly stable Fe3O4-guar gum nanocomposite using ultrasound was reported. Thermal gravimetric analysis, fourier transform infrared spectroscopy, X-ray diffractometry, field emission scanning electron microscopy, energy dispersive spectroscopy, high resolution transmission electron microscopy and X-ray photoelectron spectroscopy were used to characterize the crystal structure, size and morphology, elemental composition, metal-metal and metal-oxygen bonds of the synthesized nanocomposites...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28946243/effect-of-guar-gum-conjugation-on-functional-antioxidant-and-antimicrobial-activity-of-egg-white-lysozyme
#20
Afshan Mumtaz Hamdani, Idrees Ahmed Wani, Naseer Ahmad Bhat, Raushid Ahmad Siddiqi
This study was undertaken to analyze the effect of conjugation of egg-white lysozyme with guar gum. Lysozyme is an antimicrobial polypeptide that can be used for food preservation. Its antibacterial activity is limited to gram positive bacteria. Conjugation with polysaccharides like guar gum may broaden its activity against gram negatives. Conjugate was developed through Maillard reaction. Assays carried out included sugar estimation, SDS-PAGE, GPC, color, FT-IR, DSC, thermal stability, solubility, emulsifying, foaming and antioxidant activity...
February 1, 2018: Food Chemistry
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