Xue Xiong, Qingji Huo, Kexin Li, Changpeng Cui, Chunyi Chang, Charles Park, BonHeon Ku, Chin-Suk Hong, HeeChang Lim, Pankita H Pandya, M Reza Saadatzadeh, Khadijeh Bijangi-Vishehsaraei, Chien-Chi Lin, Melissa A Kacena, Karen E Pollok, Andy Chen, Jing Liu, William R Thompson, Xue-Lian Li, Bai-Yan Li, Hiroki Yokota
Rationale: Osteosarcoma (OS), a common malignant bone tumor, calls for the investigation of novel treatment strategies. Low-intensity vibration (LIV) presents itself as a promising option, given its potential to enhance bone health and decrease cancer susceptibility. This research delves into the effects of LIV on OS cells and mesenchymal stem cells (MSCs), with a primary focus on generating induced tumor-suppressing cells (iTSCs) and tumor-suppressive conditioned medium (CM). Methods: To ascertain the influence of vibration frequency, we employed numerical simulations and conducted experiments to determine the most effective LIV conditions...
2024: Theranostics