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https://www.readbyqxmd.com/read/28940847/genetic-mapping-using-1-4m-snp-array-refined-loci-for-fatty-acid-composition-traits-in-chinese-erhualian-and-bamaxiang-pigs
#1
J Zhang, Y Zhang, H Gong, L Cui, T Huang, H Ai, J Ren, L Huang, B Yang
Chinese indigenous pigs display marked genetic and phenotypic differences compared with western commercial pigs. In this study, we tested the association between 660K SNPs and longissimus muscle fatty acid composition traits in Chinese Erhualian (n = 331) and Bamaxiang (n = 315) pigs based on a customized 1.4 million SNP array. We identified a total of 64 significant associations for 20 fatty acid composition traits at the p-value threshold of 1 × 10(-6) among which 42 associations in low linkage disequilibrium (r(2 ) < ...
September 20, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28935932/cannabidiol-attenuates-alcohol-induced-liver-steatosis-metabolic-dysregulation-inflammation-and-neutrophil-mediated-injury
#2
Yuping Wang, Partha Mukhopadhyay, Zongxian Cao, Hua Wang, Dechun Feng, György Haskó, Raphael Mechoulam, Bin Gao, Pal Pacher
Cannabidiol (CBD) is a non-psychoactive component of marijuana, which has anti-inflammatory effects. It has also been approved by FDA for various orphan diseases for exploratory trials. Herein, we investigated the effects of CBD on liver injury induced by chronic plus binge alcohol feeding in mice. CBD or vehicle was administered daily throughout the alcohol feeding study. At the conclusion of the feeding protocol, serums samples, livers or isolated neutrophils were utilized for molecular biology, biochemistry and pathology analysis...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922023/fatty-acid-synthase-fasn-as-a-therapeutic-target-in-breast-cancer
#3
Javier A Menendez, Ruth Lupu
Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a model to explain how FASN is intertwined with various signaling networks to cell-autonomously regulate breast cancer initiation and progression, FASN has received considerable attention as a therapeutic target. However, despite the ever-growing evidence demonstrating the involvement of FASN as part of the cancer-associated metabolic reprogramming, translation of the basic science-discovery aspects of FASN blockade to the clinical arena remains a challenge...
September 18, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28888611/comparison-of-mammary-lipid-metabolism-in-dairy-cows-and-goats-fed-diets-supplemented-with-starch-plant-oil-or-fish-oil
#4
L Bernard, P G Toral, Y Chilliard
A direct comparison of cow and goat performance and milk fatty acid (FA) responses to diets known to induce milk fat depression in the bovine has suggested interspecies differences in rumen and mammary lipid metabolism. Thus, this study was conducted to infer some potential mechanisms responsible for the differences in mammary lipogenesis due to diet and ruminant species. To meet this objective, 12 cows and 15 goats were fed a basal diet (control), a similar diet supplemented with 2.2% fish oil (FO), or a diet containing 5...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28874144/circadian-disruption-promotes-tumor-growth-by-anabolic-host-metabolism-experimental-evidence-in-a-rat-model
#5
Natalí N Guerrero-Vargas, Raful Navarro-Espíndola, Mara A Guzmán-Ruíz, María Del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M Buijs, Carolina Escobar
BACKGROUND: Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy metabolism, immune dysfunction and cancer. We hypothesized that constant light (LL) in rats may facilitate tumor growth via disrupted metabolism and increased inflammatory response in the host, inducing a propitious microenvironment for tumor cells. METHODS: Male Wistar rats were exposed to LL or a regular light-dark cycle (LD) for 5 weeks...
September 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28871635/fatty-acid-synthase-as-a-potential-therapeutic-target-in-feline-oral-squamous-cell-carcinoma
#6
J Z Walz, J Saha, A Arora, A Khammanivong, M G O'Sullivan, E B Dickerson
Oral squamous cell carcinoma (OSCC) is an aggressive and treatment-resistant malignancy in both feline and human patients. Recent work has demonstrated aberrant expression of fatty acid synthase (FASN) and an increased capacity for lipogenesis in human OSCC and other cancers. In human OSCC, inhibition of FASN decreased cell viability and growth in vitro, and diminished tumour growth and metastasis in murine preclinical models. This study aimed to characterize FASN as a therapeutic target in feline OSCC. Immunohistochemistry revealed high FASN expression in primary feline OSCC tumours, and FASN expression was detected in OSCC cell lines (3 feline and 3 human) by immunoblotting and quantitative real-time-polymerase chain reaction (qRT-PCR)...
September 4, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28869259/anti-hyperlipidemic-effect-of-rice-bran-polysaccharide-and-its-potential-mechanism-in-high-fat-diet-mice
#7
Ying Nie, Feijun Luo, Long Wang, Tao Yang, Limin Shi, Xinhua Li, Junjun Shen, Wei Xu, Ting Guo, Qinlu Lin
Hyperlipidemia occurs very often in modern society along with a high calorie intake and is regarded as one of the greatest risk factors for the prevalence of cardiac vascular disease (CVD). In this study, we investigated the anti-hyperlipidemic effect of the rice bran polysaccharides (RBP) and its mechanism in a high fat diet animal model. 60 ICR mice were randomly divided into 3 groups, which included Control, HFD (high fat diet) and HFD + RBP, and each group included 20 mice. The control group was fed with a standard diet while the other two groups were fed with HFD...
September 4, 2017: Food & Function
https://www.readbyqxmd.com/read/28867816/dairy-product-consumption-interacts-with-glucokinase-gck-gene-polymorphisms-associated-with-insulin-resistance
#8
Marine S Da Silva, Dominic Chartrand, Marie-Claude Vohl, Olivier Barbier, Iwona Rudkowska
Dairy product intake and a person's genetic background have been reported to be associated with the risk of type 2 diabetes (T2D). The objective of this study was to examine the interaction between dairy products and genes related to T2D on glucose-insulin homeostasis parameters. A validated food frequency questionnaire, fasting blood samples, and glucokinase (GCK) genotypes were analyzed in 210 healthy participants. An interaction between rs1799884 in GCK and dairy intake on the homeostasis model assessment of insulin resistance was identified...
August 30, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28866102/liver-steatosis-in-hypothalamic-obese-rats-improves-after-duodeno-jejunal-bypass-by-reduction-in-de-novo-lipogenesis-pathway
#9
Gabriela Moreira Soares, Kathia Regina Cantelli, Sandra Lucinei Balbo, Rosane Aparecida Ribeiro, Ana Claudia Paiva Alegre-Maller, Helena Cristina Barbosa-Sampaio, Antonio Carlos Boschero, Allan Cezar Faria Araújo, Maria Lúcia Bonfleur
AIMS: Hypothalamic obesity is a severe condition without any effective therapy. Bariatric operations appear as an alternative treatment, but the effects of this procedure are controversial. We, herein, investigated the effects of duodeno-jejunal bypass (DJB) surgery upon the lipid profile and expression of genes and proteins, involved in the regulation of hepatic lipid metabolism, in hypothalamic obese (HyO) rats. METHODS: During the first 5days of life, male newborn Wistar rats received subcutaneous injections of monosodium glutamate [4g/kg body weight, HyO group] or saline (control, CTL group)...
August 30, 2017: Life Sciences
https://www.readbyqxmd.com/read/28866046/formaldehyde-alters-triglyceride-synthesis-and-very-low-density-lipoprotein-secretion-in-a-time-dependent-manner
#10
Jianying Bai, Pan Wang, Yanfei Liu, Yan Zhang, Yaofu Li, Zhen He, Lifang Hou, Ruifeng Liang
Formaldehyde is a common indoor air pollutant that is toxic to the liver. This study aimed to investigate the effects of formaldehyde on triglyceride metabolism in human hepatocellular carcinoma cells (HepG2). Cell viability was detected using a MTT (3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide) assay. Following treatment with different concentrations of formaldehyde for 24 and 48h, the intra and extra-hepatocellular triglyceride (TG) content was determined using a chemical-enzymatic method; Western blotting was used to detect the levels of fatty acid synthesis and VLDL-related proteins...
August 30, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28853872/oryzanol-modifies-high-fat-dietary-hfd-induced-obesity-expression-profile-and-inflammation-response-of-hepatic-tissues-in-mice
#11
Long Wang, Qinlu Lin, Tao Yang, Ying Liang, Yi Luo, Ying Nie, Junjun Shen, Xiangjin Fu, Yiping Tang, Feijun Luo
Hyperlipidemia occurs very often in modern society along with high calorie intake and it is one of the greatest risk factors caused multiple diseases. In the study, we investigated the anti-hyperlipidemic effect of oryzanol and its molecular mechanism in high fat diet (HFD) mouse model. 60 ICR mice were randomly divided into 3 groups, which include control group, HFD group and HFD+Ory group, and each group has 20 mice. The HFD+Ory group was additionally fed with 100 mg/kg of oryzanol by intragastric administration...
August 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28852047/tca-cycle-rewiring-fosters-metabolic-adaptation-to-oxygen-restriction-in-skeletal-muscle-from-rodents-and-humans
#12
Daniele Capitanio, Chiara Fania, Enrica Torretta, Agnese Viganò, Manuela Moriggi, Valentina Bravatà, Anna Caretti, Denny Z H Levett, Michael P W Grocott, Michele Samaja, Paolo Cerretelli, Cecilia Gelfi
In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to be able to react to changes in substrates and O2 delivery by tuning its metabolism. The present study provides a comprehensive overview of skeletal muscle metabolic adaptation to hypoxia in mice and in human subjects exposed for 7/9 and 19 days to high altitude levels. The investigation was carried out combining proteomics, qRT-PCR mRNA transcripts analysis, and enzyme activities assessment in rodents, and protein detection by antigen antibody reactions in humans and rodents...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837883/environmental-exposure-to-a-major-urban-wastewater-effluent-effects-on-the-energy-metabolism-of-northern-pike
#13
Julie Reinling, Magali Houde, Jonathan Verreault
Municipal wastewater effluents (MWWEs) consist of dynamic and complex mixtures of chemical and biological compounds that can alter the health of exposed aquatic organisms. Disturbance of energy metabolism has been reported in fish exposed to MWWEs. However, there is a scarcity of knowledge on the physiological events leading to perturbation of energy balance and thyroid regulation, and associated lipid metabolism. The objective of the present study was to use a set of biomarkers, from gene transcription to body condition, to investigate the effects of a chronic environmental exposure to a major primary MWWE on fatty acid metabolism and thyroid hormone levels in northern pike (Esox lucius) collected from the St...
August 4, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28835435/mir-15b-negatively-correlates-with-lipid-metabolism-in-mammary-epithelial-cells
#14
Meiqiang Chu, Yong Zhao, Shuai Yu, Yanan Hao, Pengfei Zhang, Yanni Feng, Hongfu Zhang, Dongxue Ma, Jing Liu, Ming Cheng, Lan Li, Wei Shen, Hongfang Cao, Qiang Li, Lingjiang Min
Mammary epithelial cells are regulated by steroid hormones, growth factors, and even microRNAs. MiR-15b has been found to regulate lipid metabolism in adipocytes; however its effects on lipid metabolism in mammary epithelial cells, the cells of lipid synthesis and secretion, are as yet unknown. The main purpose of this investigation was to explore the effect of miR-15b on lipid metabolism in mammary epithelial cells, along with the underlying mechanisms. MiR-15b was overexpressed or inhibited by miRNA mimics or inhibitors; subsequently lipid formation in mammary epithelial cells, and proteins related to lipid metabolism, were investigated...
August 23, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28833137/tert-ezh2-network-regulates-lipid-metabolism-and-dna-damage-responses-in-glioblastoma
#15
Fahim Ahmad, Shruti Patrick, Touseef Sheikh, Vikas Sharma, Pankaj Pathak, Prit Benny Malgulwar, Anupam Kumar, Shanker Datt Joshi, Chitra Sarkar, Ellora Sen
Elevated expression of enhancer of zeste homolog 2 (EZH2) - a histone H3K27 methyltransferase was observed in gliomas harboring telomerase reverse transcriptase (TERT) promoter mutations. Given the known involvement of TERT and EZH2 in glioma progression, the co-relation between the two and subsequently its involvement in metabolic programming was investigated. Inhibition of hTERT either pharmacologically or through genetic manipulation not only decreased EZH2 expression, but also (i) abrogated FASN levels, (ii) decreased de novo fatty acid accumulation, and (iii) increased Ataxia-telangiectasia mutated (ATM) phosphorylation levels...
August 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28827398/network-analyses-identify-liver-specific-targets-for-treating-liver-diseases
#16
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Boren, Adil Mardinoglu
We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co-expression networks (CNs) for 46 human tissues and liver cancer to explore the functional relationships between genes and examined the overlap between functional and physical interactions. Since increased de novo lipogenesis is a characteristic of nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC), we investigated the liver-specific genes co-expressed with fatty acid synthase (FASN)...
August 21, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28819221/functional-validation-of-gpihbp1-and-identification-of-a-functional-mutation-in-gpihbp1-for-milk-fat-traits-in-dairy-cattle
#17
Jie Yang, Xuan Liu, Dan Wang, Chao Ning, Haifei Wang, Qin Zhang, Li Jiang
In a previous genome-wide association study (GWAS) on milk production traits in a Chinese Holstein population, we revealed that GPIHBP1 is a novel promising candidate gene for milk fat content traits. In this study, we performed over-expression and RNAi experiments on GPIHBP1 in bovine primary mammary epithelial cells. The results showed that the expression of several important milk fat-related genes (LPL, CD36, VLDLR, ACACA and FASN) increased or decreased when the expression of GPIHBP1 was up- or down-regulated...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818460/the-design-and-synthesis-of-a-novel-compound-of-berberine-and-baicalein-that-inhibits-the-efficacy-of-lipid-accumulation-in-3t3-l1-adipocytes
#18
Mengjiao Hao, Zhuoji Guan, Yan Li, Lixian Liu, Xiao Yuan, Ying Gao, Weimin Li
The combination of berberine and baicalein may have a better therapeutic effect against disease. To explore the combined effect of baicalein and berberine in the treatment of obesity, we designed and synthesized a hybrid compound, and its biological activities were evaluated in 3T3-L1 adipocytes. The structures of the berberine-baicalein (BBS) compounds were confirmed by (1)H NMR, (13)C NMR, ultraviolet spectroscopy and high resolution mass spectrometry (HRMS). The present study showed that the IC50 values of the inhibitory effects of baicalein, berberine and BBS against 3T3-L1 cells were 29...
August 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28816006/cd38-deficiency-suppresses-adipogenesis-and-lipogenesis-in-adipose-tissues-through-activating-sirt1-ppar%C3%AE-signaling-pathway
#19
Ling-Fang Wang, Lian-Jie Miao, Xiao-Nv Wang, Cong-Cong Huang, Yi-Song Qian, Xuan Huang, Xiao-Lei Wang, Wan-Zhu Jin, Guang-Ju Ji, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin
It has been recently reported that CD38 was highly expressed in adipose tissues from obese people and CD38-deficient mice were resistant to high-fat diet (HFD)-induced obesity. However, the role of CD38 in the regulation of adipogenesis and lipogenesis is unknown. In this study, to explore the roles of CD38 in adipogenesis and lipogenesis in vivo and in vitro, obesity models were generated with male CD38(-/-) and WT mice fed with HFD. The adipocyte differentiations were induced with MEFs from WT and CD38(-/-) mice, 3T3-L1 and C3H10T1/2 cells in vitro...
August 16, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28811332/de-novo-lipid-synthesis-facilitates-gemcitabine-resistance-through-endoplasmic-reticulum-stress-in-pancreatic-cancer
#20
Saber Tadros, Surendra K Shukla, Ryan J King, Venugopal Gunda, Enza Vernucci, Jaime Abrego, Nina CHaika, Fang Yu, Audrey J Lazenby, Lyudmyla Berim, Jean L Grem, Aaron Sasson, Pankaj K Singh
Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single agent therapy for pancreatic cancer. While the prognosis in pancreatic cancer remains grim in part due to poor response to therapy, previous attempts at identifying and targeting the resistance mechanisms have not been very successful. By leveraging TCGA dataset, we identified lipid metabolism as the metabolic pathway that most significantly correlated with poor gemcitabine response in pancreatic cancer patients...
August 15, 2017: Cancer Research
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