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https://www.readbyqxmd.com/read/29334602/high-dose-metformin-plus-temozolomide-shows-increased-anti-tumor-effects-in-glioblastoma-in-vitro-and-in-vivo-compared-with-monotherapy
#1
Jung Eun Lee, Ji Hee Lim, Yong Kil Hong, Seung Ho Yang
Purpose: The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo. Materials and Methods: We investigated the efficacy of combined treatment with TMZ and metformin using cell viability and apoptosis assays. A GBM orthotopic mice model was established by inoculation of 5x105 U87 cells and treated with metformin, TMZ, and the combination for 4 weeks. Western blotting and immunofluorescence of tumor specimens were analyzed to investigate AMP-activated protein kinase (AMPK) and AKT pathway...
January 10, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29331496/maternal-betaine-supplementation-attenuates-glucocorticoid-induced-hepatic-lipid-accumulation-through-epigenetic-modification-in-adult-offspring-rats
#2
Nannan Zhao, Shu Yang, Yimin Jia, Bo Sun, Bin He, Ruqian Zhao
There are lots of reports about alleviation of NAFLD by dietary supplements of betaine. However, it remains unclear whether maternal betaine supplementation can also ameliorate NAFLD in offspring. Hence, twenty pregnant rats were fed with a basal diet with or without betaine (1%), and then the female offspring rats were raised at 3 months of age followed by 3 weeks of physiological saline or dexamethasone in a dose of 0.1 mg/kg body mass every day via intraperitoneal injection. In this study, maternal betaine supplementation significantly (P<...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331414/inhibition-of-fasn-and-er%C3%AE-signalling-during-hyperglycaemia-induced-matrix-specific-emt-promotes-breast-cancer-cell-invasion-via-a-caveolin-1-dependent-mechanism
#3
H A Zielinska, J M P Holly, A Bahl, C M Perks
Since disturbed metabolic conditions such as obesity and diabetes can be critical determinants of breast cancer progression and therapeutic failure, we aimed to determine the mechanism responsible for their pro-oncogenic effects. Using non-invasive, epithelial-like ERα-positive MCF-7 and T47D human breast cancer cells we found that hyperglycaemia induced epithelial to mesenchymal transition (EMT), a key programme responsible for the development of metastatic disease. This was demonstrated by loss of the epithelial marker E-cadherin together with increases in mesenchymal markers such as vimentin, fibronectin and the transcription factor SLUG, together with an enhancement of cell growth and invasion...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29321577/8u-a-pro-apoptosis-cell-cycle-arrest-compound-suppresses-invasion-and-metastasis-through-hsp90%C3%AE-downregulating-and-pi3k-akt-inactivation-in-hepatocellular-carcinoma-cells
#4
Ning Wang, Shaopeng Chen, Bin Zhang, Shangfu Li, Feng Jin, Dan Gao, Hongxia Liu, Yuyang Jiang
8u, an acridine derivative, has been proved effective anti-hepatocarcinoma effect, while the underlying mechanism remains unclear. Here, metabolomics and proteomics approaches were applied to study its anti-cancer mechanism and explore its effect on HepG2 cells' invasion and metastasis abilities. The results showed that 8u significantly suppressed HepG2 cells migration and enhanced cell-to-cell junctions. The inhibition effect of 8u on invasion and metastasis disappeared after HSP90α gene silencing, and was reversed after HSP90α overexpression...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314446/effects-of-an-immune-stimulant-inactivated-mycobacterium-phlei-on-the-growth-performance-as-well-as-meat-quality-of-fattening-pigs
#5
Jin-Feng Zhong, Wei-Gao Wu, Aseyinjan Tastan, Xiao-Qing Zhang, Bin Wang, Xiao-Peng Tang, Re-Jun Fang
Inactivated mycobacterium phlei (M. phlei) is well known for its immune-stimulatory functions in humans and livestock, but less information is available about the influence on meat quality of pigs when used as a feed additive. This study was designed to evaluate the effects of inactivated M. phlei on growth performance as well as meat quality of fattening pigs. A total of 240 cross-bred pigs ([Landrace × Yorkshire] × Duroc) with initial body weight of 80.14 ± 0.29 kg were randomly allocated to five treatments, each of which consisted of eight replicates with 6six pigs per replicate...
January 3, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29306075/fasn-tgf-%C3%AE-1-pd-l1-axis-contributes-to-the-development-of-resistance-to-nk-cell-cytotoxicity-of-cisplatin-resistant-lung-cancer-cells
#6
MingJing Shen, Ying Tsai, Rongying Zhu, Peter C Keng, Yongbing Chen, Yuhchyau Chen, Soo Ok Lee
Cisplatin remains the most effective therapy for non-small cell lung cancer (NSCLC). We previously have found cisplatin-resistant lung cancer cells (A549CisR and H157CisR) were more resistant to natural killer (NK) cell-mediated cytotoxicity than parental cells. We also discovered that fatty acid synthase (FASN) levels in cisplatin-resistant cells were significantly higher than parental cells. To reveal whether a link exists between the up-regulated FASN levels and higher resistance to NK cell cytotoxicity, we performed inhibition studies using a FASN inhibitor and applied the FASN knockdown approach...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29302209/histone-deacetylase-inhibition-attenuates-hepatic-steatosis-in-rats-with-experimental-cushing-s-syndrome
#7
Mina Kim, Hae-Ahm Lee, Hyun-Min Cho, Seol-Hee Kang, Eunjo Lee, In Kyeom Kim
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic hormone (ACTH; 40 ng/kg/day) to Sprague-Dawley rats by subcutaneous infusion with osmotic mini-pumps. We administered the HDACi, sodium valproate (VPA; 0...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29288662/autophagy-dysregulation-caused-by-apom-deficiency-plays-an-important-role-in-liver-lipid-metabolic-disorder
#8
Xiao Zhang, Puhong Zhang, Jialin Gao, Qiang Huang
Autophagy is thought to be a key mechanism in maintaining the balance of liver lipid metabolism. However, the relationship between apolipoprotein M (ApoM) and autophagy has not been reported, and the role of ApoM in triglyceride metabolism is still unclear. In this study, we investigated the correlation between ApoM and autophagy and liver triglyceride metabolism in ApoM-knockout animal and cellular models. First, we observed that spontaneous hepatic steatosis developed in the liver of adult ApoM-/- mice, which was presented as the accumulation of large quantities of lipid droplets in hepatocytes under electron microscopy; Oil Red O staining showed significant accumulation of triglycerides...
December 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29282029/docosahexaenoic-acid-reduces-sterol-regulatory-element-binding-protein-1-and-fatty-acid-synthase-expression-and-inhibits-cell-proliferation-by-inhibiting-pakt-signaling-in-a-human-breast-cancer-mcf-7-cell-line
#9
Li-Hsuan Huang, Hsin-Yun Chung, Hui-Min Su
BACKGROUND: Fatty acid synthase (FASN), the major enzyme in de novo fatty acid synthesis, is highly expressed in breast cancer and its expression is reduced by polyunsaturated fatty acids (PUFAs) in liver. We previously found a positive association between rat mammary tumor levels of the n-6 PUFA arachidonic acid (AA) and tumor weight. We examined the roles of the major n-3 PUFA, docosahexaenoic acid (DHA, 22:6n-3), and the major n-6 PUFA, AA, in FASN expression in, and proliferation of, human breast cancer MCF-7 cells...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29274966/fetuin-a-a-negative-acute-phase-protein-linked-to-adipose-tissue-function-in-periparturient-dairy-cows
#10
Clarissa Strieder-Barboza, Jonas de Souza, William Raphael, Adam L Lock, G Andres Contreras
Fetuin-A (FetA) is a free fatty acid transporter and an acute-phase protein that enhances cellular lipid uptake and lipogenesis. In nonruminants, FetA is involved in lipid-induced inflammation. Despite FetA importance in lipid metabolism and inflammation, its expression and dynamics in adipose tissue (AT) of dairy cows are unknown. The objectives of this study were to (1) determine serum and AT FetA dynamics over the periparturient period and in mid-lactation cows in negative energy balance (NEB) after a feed restriction protocol and (2) characterize how an inflammatory challenge affects adipocyte FetA expression...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29273553/association-between-fasn-gene-polymorphisms-ultrasound-carcass-traits-and-intramuscular-fat-in-qinchuan-cattle
#11
Sayed Haidar Abbas Raza, Linsheng Gui, Rajwali Khan, Nicola M Schreurs, Wang Xiaoyu, Sen Wu, Chugang Mei, Li Wang, Xueyao Ma, Dawei Wei, Hongfang Guo, Song Zhang, Xingping Wang, Hubdar Ali Kaleri, Linsen Zan
Fatty acid synthase (FASN) is an enzyme involved with fat deposition and fatty acid composition in cattle. This study was conducted to detect single nucleotide polymorphisms (SNPs) of the FASN gene and explore their relationships with ultrasound carcass traits in order to assess the potential use of the FASN gene for the breeding selection of Qinchuan cattle for desirable carcass traits. The frequencies of SNP g.12740C>T, g.13192T>C and g.13232C>T were identified in 525 individual Qinchuan cattle which were also assessed for backfat depth, eye muscle area and intramuscular fat by ultrasound...
December 19, 2017: Gene
https://www.readbyqxmd.com/read/29250447/electronic-northern-analysis-of-genes-and-modeling-of-gene-networks-underlying-bovine-milk-fat-production
#12
Bhaskar Ganguly, Tanuj Kumar Ambwani, Sunil Kumar Rastogi
Milk fat is one of the most important economic traits in dairy animals. Yet, the biological machinery involved in milk fat synthesis remains poorly understood. In the present study, expression profiling of 45 genes involved in lipid biosynthesis and secretion was performed using a computational approach to identify those genes that are differentially expressed in mammary tissue. Transcript abundance was observed for genes associated with nine bioprocesses, namely, fatty acid import into cells, xenobiotic and cholesterol transport, acetate and fatty acid activation and intracellular transport, fatty acid synthesis and desaturation, triacylglycerol synthesis, sphingolipid synthesis, lipid droplet formation, ketone body utilization, and regulation of transcription in mammary, skin, and muscle tissue...
2017: Genetics Research International
https://www.readbyqxmd.com/read/29237473/sexual-dimorphism-in-the-hepatic-protein-response-to-a-moderate-trans-fat-diet-in-senescence-accelerated-mice
#13
Steven A Bloomer, Kathryn E Wellen, Gregory C Henderson
BACKGROUND: Aging is characterized by increases in inflammation and oxidative stress, conditions that are exacerbated by environmental factors such as diet. In this study, we investigated the effects of a trans-fatty acid (TFA) diet on the liver in adult (25 wk) and old (60 wk) senescence-accelerated mice (SAMP8 strain) of both sexes. Our goal was to assess the effects of the diet on protein markers of inflammation and oxidative stress in the liver. METHODS: Male and female mice were placed on life-long diets containing similar amounts of total fat (17%), with differing amounts of TFA: 2% (moderate TFA group) or 0...
December 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29230177/effect-of-morinda-citrifolia-noni-enriched-diet-on-hepatic-heat-shock-protein-and-lipid-metabolism-related-genes-in-heat-stressed-broiler-chickens
#14
Joshua Flees, Hossein Rajaei-Sharifabadi, Elizabeth Greene, Lesleigh Beer, Billy M Hargis, Laura Ellestad, Tom Porter, Annie Donoghue, Walter G Bottje, Sami Dridi
Heat stress (HS) has been reported to alter fat deposition in broilers, however the underlying molecular mechanisms are not well-defined. The objectives of the current study were, therefore: (1) to determine the effects of acute (2 h) and chronic (3 weeks) HS on the expression of key molecular signatures involved in hepatic lipogenic and lipolytic programs, and (2) to assess if diet supplementation with dried Noni medicinal plant (0.2% of the diet) modulates these effects. Broilers (480 males, 1 d) were randomly assigned to 12 environmental chambers, subjected to two environmental conditions (heat stress, HS, 35°C vs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29228426/lncrna-hotair-contributes-to-the-tumorigenesis-of-nasopharyngeal-carcinoma-via-up-regulating-fasn
#15
D-D Ma, L-L Yuan, L-Q Lin
OBJECTIVE: The therapeutic options for nasopharyngeal carcinoma (NPC) treatment have been restricted mainly to radiotherapy or chemotherapy, and the clinical treatment effect remains unsatisfactory. The primary purpose of this study was to investigate the molecular mechanisms of NPC and to find effective novel therapeutic targets for NPC. PATIENTS AND METHODS: In order to analyze the expression level of lncRNA HOTAIR and FASN in human NPC clinical tissues or NPC cells, total RNA was extracted with TRIzol and the relative mRNA expression levels were detected by quantitative Real-time PCR...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29207408/joshua-p-klein-md-phd-fana-fasn-faan
#16
David M Greer
No abstract text is available yet for this article.
October 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/29197622/protective-effects-of-dioscin-against-fructose-induced-renal-damage-via-adjusting-sirt3-mediated-oxidative-stress-fibrosis-lipid-metabolism-and-inflammation
#17
Yujie Qiao, Lina Xu, Xufeng Tao, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Zeyao Tang, Xiaodong Ma, Kexin Liu, Jinyong Peng
In the present work, the effects and possible mechanisms of dioscin, one natural product from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose-induced renal injury in rats were tested. The results showed that dioscin significantly restored fructose-induced renal injury by decreasing the levels of Cr, BUN, and rehabilitating histopathological changes. In addition, dioscin markedly adjusted the levels of MDA, SOD and GSH-Px, reduced ROS level in renal tissue, and decreased the levels of TG, FFA, α-SMA and COL1A...
December 2, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29193738/cooperative-role-of-the-glp-1-receptor-and-%C3%AE-3-adrenergic-mediated-signaling-on-fat-mass-reduction-through-the-down-regulation-of-pka-akt-ampk-signaling-in-the-adipose-tissue-and-muscle-of-rats
#18
Juan Decara, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Antonia Serrano, Francisco Javier Pavón, Carlos Dieguez, Rubén Nogueiras, Fernando Rodríguez de Fonseca, Juan Suárez
AIM: To explore the cooperation of GLP-1 receptor and β3-adrenergic receptor-mediated signaling in the control of fat mass/feeding behavior by studying the effects of a combined therapy composed of the GLP-1R agonist liraglutide and the β3-AR agonist CL316243. METHODS: The study included the analysis of key mechanisms regulating lipid/cholesterol metabolism, and thermogenesis in brown (BAT) and epididymal white (eWAT) adipose tissues, abdominal muscle and liver of male rats...
November 28, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29185886/fish-oil-suppresses-body-fat-accumulation-in-zebrafish
#19
Shinichi Meguro, Takahiro Hasumura
Zebrafish is an often used model of vertebrate lipid metabolism. In this article, we examined the effects of diets rich in fish oil, a dietary fat that has been shown to have antiobesity effects in mammals, or lard on body fat accumulation in zebrafish. Adult female zebrafish were fed a high-fat diet containing 20% (w/w) fish oil or lard for 4 weeks. Fish in the fish oil diet group had less body fat accumulation compared with those in the lard diet group. In the intestine, expression of genes for the alpha (hadhaa) and beta (hadhb) subunits of the beta-oxidation enzyme hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase was significantly increased in the fish oil diet group compared with the lard diet group (p < 0...
November 29, 2017: Zebrafish
https://www.readbyqxmd.com/read/29181403/gosb-inhibits-triacylglycerol-synthesis-and-promotes-cell-survival-in-mouse-mammary-epithelial-cells
#20
Gaoxiao Xu, Saixing Duan, Jianye Hou, Zhongxin Wei, Guangwei Zhao
It has been demonstrated that the activator protein related transcription factor Finkel-Biskis-Jinkins murine osteosarcoma B (GosB) is involved in preadipocyte differentiation and triacylglycerol synthesis. However, the role of GosB in regulating the synthesis of milk fatty acid in mouse mammary glands remains unclear. This research uncovered potentially new roles of GosB in suppressing milk fatty acid synthesis. Results revealed that GosB had the highest expression in lung tissue and showed a higher expression level during nonlactation than during lactation...
2017: BioMed Research International
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