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https://www.readbyqxmd.com/read/28917852/bio-responsive-alginate-keratin-composite-nanogels-with-enhanced-drug-loading-efficiency-for-cancer-therapy
#1
Zhe Sun, Zeng Yi, Huaiying Zhang, Xiaomin Ma, Wen Su, Xiaoyu Sun, Xudong Li
This article presents a novel dual-stimuli responsive nanogel prepared from human hair keratin and alginate through simple crosslinking method. Keratin offer the crosslinking structure and bio-responsive ability and alginate ameliorated properties of nanogels including particle size, stability and drug loading capacity. The resultant keratin-alginate nanogels (KSA-NGs) could function as promising vectors for doxorubicin hydrochloride (DOX) with a super-high drug-loading rate of 52.9% (w/w) and dual-stimuli responsive behavior to GSH and trypsin...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917151/a-novel-self-nanoemulsifying-formulation-for-sunitinib-evaluation-of-anticancer-efficacy
#2
R Nazari-Vanani, N Azarpira, H Heli, K Karimian, N Sattarahmady
Breast cancer is the top cancer and a main cause of death among women. The incidence of this cancer is increasing in the world. Sunitinib maleate is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that inhibits tumor cell proliferation and angiogenesis, and has been administrated as an anticancer drug. Self-nanoemulsifying drug delivery system (SNEDDS) is an isotopic mixture of an oil, a surfactant and usually a co-surfactant, which can spontaneously form fine oil-in-water nanoemulsion in aqueous media...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28916966/evaluation-of-in-vitro-efficacy-of-docetaxel-loaded-calcium-carbonate-aragonite-nanoparticles-dtx-caco3np-on-4t1-mouse-breast-cancer-cell-line
#3
Nahidah Ibrahim Hammadi, Yusuf Abba, Mohd Noor Mohd Hezmee, Intan Shameha Abdul Razak, Aminu Umar Kura, Zuki Abu Bakar Zakaria
Cockle shell-derived calcium carbonate nanoparticles have shown promising potentials as slow drug-releasing compounds in cancer chemotherapy. In this study, we evaluated the in vitro efficacy of docetaxel (DTX)-loaded CaCO3NP on 4T1 cell line. This was achieved by evaluating the following: cytotoxicity using MTT assay, fluorescence imaging, apoptosis with Annexin V assay, cell cycle analysis, scanning (SEM) and transmission electron microscopy (TEM), and scratch assay. Based on the results, DTX-CaCO3NP with a DTX concentration of 0...
September 15, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28911087/an-antisense-oligonucleotide-targeting-tgf-%C3%AE-2-inhibits-lung-metastasis-and-induces-cd86-expression-in-tumor-associated-macrophages
#4
I Huber-Ruano, C Raventós, I Cuartas, C Sánchez-Jaro, A Arias, J L Parra, K Wosikowski, M Janicot, J Seoane
Background: The transforming growth factor (TGF)-β pathway is a well-described inducer of immunosuppression and can act as an oncogenic factor in advanced tumors. Several preclinical and clinical studies show that the TGF-β pathway can be considered a promising molecular target for cancer therapy. The human genome has three TGF-β isoforms and not much is known about the oncogenic response to each of the isoforms. Here, we studied the antitumor response to ISTH0047, a recently developed locked nucleic acid-modified antisense oligonucleotide targeting TGF-β2...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28900317/evaluation-of-cytotoxicity-effects-of-oleo-gum-resin-and-its-essential-oil-of-ferula-assa-foetida-and-ferulic-acid-on-4t1-breast-cancer-cells
#5
Seyyed Majid Bagheri, Amir Abdian Asl, Ali Shams, Seyyed Ali Mirghanizadeh-Bafghi, Zeynab Hafizibarjin
BACKGROUND: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. AIM: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28895057/triterpenoid-saponins-from-clinopodium-chinense-benth-o-kuntze-and-their-biological-activity
#6
Yin-Di Zhu, Jing-Yi Hong, Feng-Da Bao, Na Xing, Ling-Tian Wang, Zhong-Hao Sun, Yun Luo, Hai Jiang, Xu-Dong Xu, Nai-Liang Zhu, Hai-Feng Wu, Gui-Bo Sun, Jun-Shan Yang
Four new ursane-type triterpenoid saponins, clinopoursaponins A-D (1-4), six new oleanane-type triterpenoid saponins, clinopodiside VII-XII (5-10), as well as eight known triterpene analogues (11-18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D ((1)H and (13)C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1-18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1...
September 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28892021/near-infrared-triggered-photodynamic-therapy-toward-breast-cancer-cells-using-dendrimer-functionalized-upconversion-nanoparticles
#7
Bing-Yen Wang, Ming-Liang Liao, Guan-Ci Hong, Wen-Wei Chang, Chih-Chien Chu
Water-soluble upconversion nanoparticles (UCNPs) that exhibit significant ultraviolet, blue, and red emissions under 980-nm laser excitation were successfully synthesized for performing near infrared (NIR)-triggered photodynamic therapy (PDT). The lanthanide-doped UCNPs bearing oleate ligands were first exchanged by citrates to generate polyanionic surfaces and then sequentially encapsulated with NH₂-terminated poly(amido amine) (PAMAM) dendrimers (G4) and chlorine6 (Ce6) using a layer-by-layer (LBL) absorption strategy...
September 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28890195/gk-1-peptide-reduces-tumor-growth-decreases-metastatic-burden-and-increases-survival-in-a-murine-breast-cancer-model
#8
D Torres-García, A Pérez-Torres, K Manoutcharian, U Orbe, R Servín-Blanco, G Fragoso, E Sciutto
GK-1 is a parasite-derived peptide adjuvant of 18 amino acid-length that enhances T-cell function and increases survival in B16-F10 melanoma tumor-bearing mice. This study was designed to evaluate in vivo the antitumor efficacy of GK-1 on 4T1 mouse mammary carcinoma. BALB/c mice with palpable primary tumors were weekly intravenously injected three times with saline solution or three different concentrations (10, 50, or 100μg per mouse) of GK-1. GK-1 significantly increased lifespan (p<0.0001) and reduced the primary tumor weight (p=0...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28886271/microrna-signature-in-the-chemoprevention-of-functionally-enriched-stem-and-progenitor-pools-fespp-by-active-hexose-correlated-compound-ahcc
#9
Émilie A Graham, Jean-François Mallet, Majed Jambi, Hiroshi Nishioka, Kohei Homma, Chantal Matar
PURPOSE: Many breast cancer patients use natural compounds in their battle against breast cancer. Active Hexose Correlated Compound (AHCC®) is a cultured mushroom mycelium extract shown to favorably modulate the immune system and alleviate cancer burden. Cancer Stem cells (CSCs) are a subset of highly tumorigenic cancer cells that are thought to be responsible for recurrence. CSCs can be epigenetically regulated by microRNAs (miRNAs). We hypothesized that AHCC may influence CSCs by modulating tumor-suppressor or oncogenic miRNAs...
September 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28881584/dimerization-of-egfr-and-her2-induces-breast-cancer-cell-motility-through-stat1-dependent-acta2-induction
#10
Myeongjin Jeon, Daeun You, Soo Youn Bae, Seok Won Kim, Seok Jin Nam, Hyeon Ho Kim, Sangmin Kim, Jeong Eon Lee
The dimerization of EGFR and HER2 is associated with poor prognosis such as induction of tumor growth and cell invasion compared to when EGFR remains as a homodimer. However, the mechanism for events after dimerization in breast cancer models is not clear. We found that expressions of alpha-smooth muscle actin (ACTA2) and signal transducer and activator of transcription 1 (STAT1) significantly increased with transient or stable overexpression of HER2 in EGFR-positive breast cancer cells. ACTA2 and STAT1 expression was also increased in HER2-positive breast cancer patients...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879687/recombinant-synthesis-of-hybrid-lipid-peptide-polymer-fusions-that-self-assemble-and-encapsulate-hydrophobic-drugs
#11
Kelli M Luginbuhl, Davoud Mozhdehi, Michael Dzuricky, Parisa Yousefpour, Fred C Huang, Nicholas R Mayne, Kristen Buehne, Ashutosh Chilkoti
Inspired by biohybrid molecules that are synthesized in Nature through post-translational modification (PTM), we have exploited a eukaryotic PTM to recombinantly synthesize lipid-polypeptide hybrid materials. By co-expressing yeast N-myristoyltransferase with an elastin-like polypeptide (ELP) fused to a short recognition sequence in E. coli, we show robust and high yield modification of the ELP with myristic acid. The ELP's reversible phase behavior is retained upon myristoylation and can be tuned to span a 30-60 °C...
September 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28878282/a-novel-benzocoumarin-stilbene-hybrid-as-a-dna-ligase-i-inhibitor-with-in-vitro-and-in-vivo-anti-tumor-activity-in-breast-cancer-models
#12
Mohd Kamil Hussain, Deependra Kumar Singh, Akhilesh Singh, Mohd Asad, Mohd Imran Ansari, Mohammad Shameem, Shagun Krishna, Guru R Valicherla, Vishal Makadia, Sanjeev Meena, Amit Laxmikant Deshmukh, Jiaur R Gayen, Mohammad Imran Siddiqi, Dipak Datta, Kanchan Hajela, Dibyendu Banerjee
Existing cancer therapies are often associated with drug resistance and toxicity, which results in poor prognosis and recurrence of cancer. This necessitates the identification and development of novel therapeutics against existing as well as novel cellular targets. In this study, a novel class of Benzocoumarin-Stilbene hybrid molecules were synthesized and evaluated for their antiproliferative activity against various cancer cell lines followed by in vivo antitumor activity in a mouse model of cancer. The most promising molecule among the series, i...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878134/prevention-of-breast-cancer-skeletal-metastases-with-parathyroid-hormone
#13
Srilatha Swami, Joshua Johnson, Lance A Bettinson, Takaharu Kimura, Hui Zhu, Megan A Albertelli, Rachelle W Johnson, Joy Y Wu
Advanced breast cancer is frequently associated with skeletal metastases and accelerated bone loss. Recombinant parathyroid hormone [teriparatide, PTH(1-34)] is the first anabolic agent approved in the US for treatment of osteoporosis. While signaling through the PTH receptor in the osteoblast lineage regulates bone marrow hematopoietic niches, the effects of anabolic PTH on the skeletal metastatic niche are unknown. Here, we demonstrate, using orthotopic and intratibial models of 4T1 murine and MDA-MB-231 human breast cancer tumors, that anabolic PTH decreases both tumor engraftment and the incidence of spontaneous skeletal metastasis in mice...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28878029/interleukin-4-receptor-targeted-pro-apoptotic-peptide-blocks-tumor-growth-and-metastasis-by-enhancing-anti-tumor-immunity
#14
Sri Murugan Poongkavithai Vadevoo, Jung-Eun Kim, Gowri Rangaswamy Gunassekaran, Hyun-Kyung Jung, Lianhua Chi, Dong Eon Kim, Seung-Hyo Lee, Sin-Hyeog Im, Byungheon Lee
Cellular crosstalk between tumors and M2-polarized tumor-associated macrophages (TAMs) favors tumor progression. Upregulation of interleukin 4 receptor (IL4R) is observed in diverse tumors and TAMs. We tested whether an IL4R-targeted pro-apoptotic peptide could inhibit tumor progression. The IL4R-binding peptide (IL4RPep-1) preferentially bound to IL4R-expressing tumor cells and M2-polarized macrophages both in vitro and in 4T1 breast tumors in vivo. To selectively kill IL4R-expressing cells, we designed an IL4R-targeted pro-apoptotic peptide, IL4RPep-1-K, by adding the pro-apoptotic peptide (KLAKLAK)2 to the end of IL4RPep-1...
September 6, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28874822/carbon-dots-as1411-aptamer-nanoconjugate-for-ultrasensitive-spectrofluorometric-detection-of-cancer-cells
#15
Hasan Motaghi, Masoud Ayatollahi Mehrgardi, Philippe Bouvet
In the present study, a sensitive and selective signal-on method for aptamer based spectrofluorometric detection of cancer cells is introduced. AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells. Nucleolin, is overexpressed on the surface of cancer cells. Mouse breast 4T1, human breast MCF7, and human cervical HeLa cancer cells were selected as target cells, while human foreskin fibroblast cells HFFF-PI6 served as control cells...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874690/a-single-neonatal-administration-of-bisphenol-a-induces-higher-tumour-weight-associated-to-changes-in-tumour-microenvironment-in-the-adulthood
#16
Margarita Isabel Palacios-Arreola, Karen Elizabeth Nava-Castro, Víctor Hugo Del Río-Araiza, Nashla Yazmín Pérez-Sánchez, Jorge Morales-Montor
BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874076/multimodal-fluorescence-and-bioluminescence-imaging-reveals-transfection-potential-of-intratracheally-administered-polyplexes-for-breast-cancer-lung-metastases
#17
Antonia Geyer, Alexander Taschauer, Fatih Alioglu, Martina Anton, Julia Maier, Elisabeth Drothler, Manuela Simlinger, Sümeyye Yavuz, Haider Sami, Manfred Ogris
Local delivery of anticancer agents or gene therapeutics to lung tumors can circumvent side effects or accumulation in non-target organs, but accessibility via the alveolar side of blood-air barrier remains challenging. Polyplexes based on plasmid and linear polyethylenimine (LPEI) transfect healthy lung tissue when applied intravenously in the mouse, but direct delivery into the lungs results in low transfection of lung tissue. Nevertheless, LPEI could offer the potential to selectively transfect lung tumors, if accessible by the alveolar side...
September 6, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28873304/multifunctional-bacteria-driven-microswimmers-for-targeted-active-drug-delivery
#18
Byung-Wook Park, Jiang Zhuang, Oncay Yasa, Metin Sitti
In this study, high-performance, multifunctional bacteria-driven microswimmers are introduced using a new design and fabrication method for targeted drug delivery applications. These microswimmers are made of mostly single Escherichia coli bacterium attached to the surface of drug-loaded polyelectrolyte multilayer (PEM) microparticles with embedded magnetic nanoparticles. The PEM drug carriers are 1 μm in diameter, and are intentionally fabricated with a more viscoelastic material than the particles previously studied in the literature...
September 5, 2017: ACS Nano
https://www.readbyqxmd.com/read/28872973/splenectomy-induced-leukocytosis-promotes-intratumoral-accumulation-of-myeloid-derived-suppressor-cells-angiogenesis-and-metastasis
#19
Murat Sevmis, Digdem Yoyen-Ermis, Cisel Aydin, Elif Bilgic, Petek Korkusuz, Aysegul Uner, Erhan Hamaloglu, Gunes Esendagli, Derya Karakoc
BACKGROUND: Enlargement of the spleen is commonly observed in animal models of cancer. Here, in a breast cancer model, it was aimed to determine the effect of splenectomy on circulating and tumor-infiltrating myeloid-derived suppressor cells (MDSCs), tumor angiogenesis, and metastasis. METHODS: Mice were inoculated with 4T1 breast cancer cells and underwent splenectomy or sham laparotomy. Tumor growth and survival of animals were followed. Macroscopic and histopathological analyses were performed to determine splenomegaly and metastasis...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28872058/nanoparticles-target-early-stage-breast-cancer-metastasis-in-vivo
#20
Evgeniya Goldman, Assaf Zinger, Dana da Silva, Zvi Yaari, Ashima Kajal, Dikla Vardi-Oknin, Mor Goldfeder, Josh Schroeder, Janna Shainsky Roitman, Dov Hershkovitz, Avi Schroeder
Despite advances in cancer therapy, treating cancer after it has metastasized remains an unmet clinical challenge. In this study we demonstrate that 100-nm liposomes target triple-negative murine breast-cancer metastases post intravenous administration. Metastatic breast cancer was induced in BALB/c-mice either experimentally, by a tail vein injection of 4T1 cells, or spontaneously, after implanting a primary tumor xenograft. To track their biodistribution in vivo the liposomes were labeled with multi-modal diagnostic agents, including indocyanine green and rhodamine for whole-animal fluorescent imaging, gadolinium for magnetic resonance imaging, and europium for a quantitative biodistribution analysis...
September 5, 2017: Nanotechnology
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