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https://www.readbyqxmd.com/read/28527734/singlet-oxygen-responsive-micelles-for-enhanced-photodynamic-therapy
#1
Xiaodan Li, Min Gao, Keting Xin, Ling Zhang, Dan Ding, Deling Kong, Zheng Wang, Yang Shi, Fabian Kiessling, Twan Lammers, Jianjun Cheng, Yanjun Zhao
Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen ((1)O2). We report a (1)O2-responsive micellar nanoplatform subject to considerable size-expansion upon light triggering to facilitate on-demand release of photosensitizers. Imidazole, a well-known (1)O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible Zn(2+) and encapsulate the photosensitizer chlorin e6 (Ce6)...
May 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28526557/the-frog-skin-host-defense-peptide-frenatin-2-1s-enhances-recruitment-activation-and-tumoricidal-capacity-of-nk-cells
#2
Jelena M Pantic, Ivan P Jovanovic, Gordana D Radosavljevic, Nevena M Gajovic, Nebojsa N Arsenijevic, J Michael Conlon, Miodrag L Lukic
Frog skin is a source of peptides with various biological properties. Frenatin 2.1S, derived from norepinephrine-stimulated skin secretions of the Orinoco lime tree frog Sphaenorhynchus lacteus, exhibits immunostimulatory effects as demonstrated by the promotion of proinflammatory phenotypes of mononuclear cells in mouse peritoneal cavity and spleen. The aim of this study was to identify the populations of host cells sensitive to the action of frenatin 2.1S in vivo and to study its effects on their functional antitumor capacity...
May 16, 2017: Peptides
https://www.readbyqxmd.com/read/28522586/antitumor-synergism-and-enhanced-survival-with-a-tumor-vasculature-targeted-enzyme-prodrug-system-rapamycin-and-cyclophosphamide
#3
John J Krais, Needa Virani, Partick H McKernan, Quang Nguyen, Kar-Ming Fung, Vassilios I Sikavitsas, Carla D Kurkjian, Roger G Harrison
Mutant cystathionine gamma-lyase was targeted to phosphatidylserine exposed on tumor vasculature through fusion with annexin A1 or annexin A5.  Cystathionine gamma-lyase E58N, R118L, and E338N mutations impart non-native methionine gamma-lyase activity, resulting in tumor-localized generation of highly toxic methylselenol upon systemic administration of non-toxic selenomethionine.  The described therapeutic system circumvents systemic toxicity issues using a novel drug delivery/generation approach and avoids the administration of non-native proteins and/or DNA required with other enzyme prodrug systems...
May 18, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28515087/fxyd5-dysadherin-may-mediate-metastatic-progression-through-regulation-of-the-%C3%AE-na-k-atpase-subunit-in-4t1-mouse-breast-cancer-model
#4
Irina Lubarski-Gotliv, Kuntal Dey, Yuri Kuznetsov, Vecheslav Kalchenco, Carol Asher, Haim Garty
FXYD5 is a Na(+)-K(+)-ATPase regulator, expressed in a variety of normal epithelia. In parallel, it has been found to be associated with several types of cancer and effect lethal outcome by promoting metastasis. However, the molecular mechanism underlying FXYD5 mediated invasion, was has not yet been identified. In this study, using in vivo 4T1 murine breast cancer model, we found that FXYD5 specific shRNA significantly inhibited lung cancer metastasis, without having a substantial effect on primary tumor growth...
May 17, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28513132/%C3%AE-amylase-and-redox-responsive-nanoparticles-for-tumor-targeted-drug-delivery
#5
Yihui Li, Hang Hu, Qing Zhou, Yanxiao Ao, Chen Xiao, Jiangling Wan, Ying Wan, Huibi Xu, Zifu Li, Xiangliang Yang
Paclitaxel (PTX) is an effective antineoplastic agent and shows potent anti-tumor activity against wide spectrum of cancers. Yet, the wide clinical use of paclitaxel (PTX) is limited by its poor aqueous solubility and side effects associated with current therapeutic formulation. To tackle these obstacles, we, for the first time, report an α-amylase- and redox- responsive nanoparticles based on hydroxyethyl starch (HES) for tumor targeted delivery of PTX. PTX is conjugated onto HES by redox-sensitive disulfide bond to form HES-SS-PTX, which is confirmed with NMR, HPLC-MS, and FT-IR...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28511875/visible-light-switched-cytosol-release-of-sirna-by-amphiphilic-fullerene-derivative-to-enhance-rnai-efficacy-in-vitro-and-in-vivo
#6
Jing Wang, Lifei Xie, Tao Wang, Fengxin Wu, Jie Meng, Jian Liu, Haiyan Xu
Cationic macromolecules are attractive for use as small interfering RNA (siRNA) carriers due to their performance in non-immunological reactions, customization during synthesis, and low costs compared to viral carriers. However, their low transfection efficiency substantially hinders their application in both clinical practices and academic research, which is mostly attributable to the low capacity of siRNA/cationic macromolecule complexes to escape lysosomes. To address this challenge, we designed an amphiphilic fullerene derivative (C60-Dex-NH2) for efficient and controllable siRNA delivery...
May 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28508635/polydopamine-coated-manganese-carbonate-nanoparticles-for-amplified-magnetic-resonance-imaging-guided-photothermal-therapy
#7
Youxing Cheng, Shupeng Zhang, Ning Kang, Jianpan Huang, Xiaolin Lv, Kai Wen, Shefang Ye, Zhiwei Chen, Xi Zhou, Lei Ren
This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28507941/in-vitro-cytotoxicity-effects-of-197-au-pamamg4-and-198-au-pamamg4-nanocomposites-against-mcf7-and-4t1-breast-cancer-cell-lines
#8
Simin Janitabar-Darzi, Reza Rezaei, Kamal Yavari
Purpose: Study on gold based therapeutic agents for cancer cells deracination has become under scrutiny in recent years owing to effective treatments are not available for rapidly progressive cancers. The aim of present study was to examine efficiency of radioactive (198)Au/PAMAMG4 and non-radioactive (197)Au/PAMAMG4 nancomposites against 4T1 and MCF7 breast cancer cell lines. Methods: The PAMAMG4 dendrimer was treated with the gold anions and then, the mixture was chemically reduced by NaBH4. Prepared (197)Au/PAMAMG4 was bombarded by thermal neutrons in the Tehran Research Reactor to (198)Au/PAMAMG4 be produced...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28505136/gubenyiliu-ii-inhibits-breast-tumor-growth-and-metastasis-associated-with-decreased-heparanase-expression-and-phosphorylation-of-erk-and-akt-pathways
#9
Yi Zhang, Gan-Lin Zhang, Xu Sun, Ke-Xin Cao, Ya-Wen Shang, Mu-Xin Gong, Cong Ma, Nan Nan, Jin-Ping Li, Ming-Wei Yu, Guo-Wang Yang, Xiao-Min Wang
Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibitory effects on tumor growth and metastasis in the murine breast cancer model. Additionally, GYII suppressed the proliferation of 4T1 and MCF-7 cells in a dose-dependent manner. A better inhibitory effect on 4T1 cell proliferation and migration was found in the decomposed recipes (DR) of GYII...
May 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28504970/osteoclast-proton-pump-regulator-atp6v1c1-enhances-breast-cancer-growth-by-activating-the-mtorc1-pathway-and-bone-metastasis-by-increasing-v-atpase-activity
#10
Matthew McConnell, Shengmei Feng, Wei Chen, Guochun Zhu, Dejun Shen, Selvarangan Ponnazhagan, Lianfu Deng, Yi-Ping Li
It is known that V-ATPases (vacuolar H+-ATPase) are involved in breast cancer growth and metastasis. Part of this action is similar to their role in osteoclasts, where they're involved in extracellular acidification and matrix destruction; however, the roles of their subunits in cancer cell proliferation, signaling, and other pro-tumor actions are not well established. Analysis of TCGA data shows that V-ATPase subunit Atp6v1c1 is overexpressed or amplified in 34% of human breast cancer cases, with a 2-fold decrease in survival at 12 years...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28504877/illuminating-superoxide-anion-and-ph-enhancements-in-apoptosis-of-breast-cancer-cells-induced-by-mitochondrial-hyperfusion-using-a-new-two-photon-fluorescence-probe
#11
Wen Zhang, Xin Wang, Ping Li, Haibin Xiao, Wei Zhang, Hui Wang, Bo Tang
Mitochondrial morphology regulated by fusion and fission processes determines mitochondrial function and cell fate. Some studies showed hyperfused mitochondria could induce apoptosis in cancer cells, but the relevant molecular mechanisms remain elusive. Superoxide (O2•-) and pH play vital roles in mitochondrial dysfunction and apoptosis. Therefore, it is worthwhile to explore if there is an intimate relationship between mitochondrial hyperfusion and simultaneous changes in O2•- and pH levels, which will be helpful to uncover relevant detailed mechanism...
May 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28504251/programmable-co-delivery-of-the-immune-checkpoint-inhibitor-nlg919-and-chemotherapeutic-doxorubicin-via-a-redox-responsive-immunostimulatory-polymeric-prodrug-carrier
#12
Jing-Jing Sun, Yi-Chao Chen, Yi-Xian Huang, Wen-Chen Zhao, Yan-Hua Liu, Raman Venkataramanan, Bin-Feng Lu, Song Li
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 prodrug polymers were self-assembled into nano-sized micelles that served as a carrier to load DOX (DOX/PSSN10 micelles)...
May 8, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28504249/treating-breast-cancer-metastasis-with-cabazitaxel-loaded-polymeric-micelles
#13
Tao Zhong, Bin He, Hai-Qiang Cao, Tao Tan, Hai-Yan Hu, Ya-Ping Li, Zhi-Wen Zhang
Cancer metastasis is the primary cause of high mortality in breast cancer patients. In this study, we loaded an anti-cancer drug, cabazitaxel (CTX), into polymeric micelles (CTX-loaded polymeric micelles, PCMs), and explored their therapeutic efficacy in breast cancer metastasis. The characteristics of PCMs were investigated, and their anti-metastatic efficacy was assessed using in vitro and in vivo evaluations. PCMs had an average diameter of 50.13±11.96 nm with a CTX encapsulation efficiency of 97.02%±0...
May 1, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28501705/doxorubicin-delivered-by-a-redox-responsive-dasatinib-containing-polymeric-prodrug-carrier-for-combination-therapy
#14
Jingjing Sun, Yanhua Liu, Yichao Chen, Wenchen Zhao, Qianyu Zhai, Sanjay Rathod, Yixian Huang, Suoqin Tang, Yong Tae Kwon, Christian Fernandez, Raman Venkataramanan, Song Li
Two novel prodrug polymers POEG-b-PSSDas (redox-sensitive) and POEG-b-PCCDas (redox-insensitive), which consist of poly(oligo(ethylene glycol) methacrylate) (POEG) hydrophilic blocks and dasatinib (DAS, an oncogenic tyrosine kinases inhibitor) conjugated hydrophobic blocks, were designed as dual-functional carriers for codelivery with doxorubicin (DOX). Both carriers retained antitumor activity of DAS and could form mixed micelles with DOX. Compared to POEG-b-PCCDas micelles, incorporation of disulfide linkage into POEG-b-PSSDas micelles facilitated efficient cleavage of DAS from prodrug micelles in tumor cells/tissues, leading to a higher level of anti-tumor activity in vitro and in vivo...
May 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28501502/urtica-dioica-extract-inhibits-proliferation-and-induces-apoptosis-and-related-gene-expression-of-breast-cancer-cells-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Ali Mohammadi, Behzad Mansoori, Pooneh Chokhachi Baradaran, Vahid Khaze, Mahyar Aghapour, Mehrdad Farhadi, Behzad Baradaran
INTRODUCTION: Currently, because the prevalence of breast cancer and its consequent mortality has increased enormously in the female population, a number of studies have been designed to identify natural products with special antitumor properties. The main purpose of the present study was to determine the effect of Urtica dioica on triggering apoptosis and diminishing growth, size, and weight of the tumor in an allograft model of BALB/c mice. MATERIALS AND METHODS: In the present study, a BALB/c mouse model of breast cancer (4T1) was used...
April 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28499884/inhibition-of-ubiquitin-specific-protease-34-usp34-induces-epithelial-mesenchymal-transition-and-promotes-stemness-in-mammary-epithelial-cells
#16
Eunhye Oh, Ji Young Kim, Daeil Sung, Youngkwan Cho, Nahyun Lee, Hyunsook An, Yoon-Jae Kim, Tae-Min Cho, Jae Hong Seo
Ubiquitin-specific protease 34 (USP34) is a deubiquitinating enzyme that regulates Axin stability and plays a critical role in Wnt/β-catenin signaling. We sought to investigate the role of USP34 on epithelial-mesenchymal (EMT) induction and its effects on mammary epithelial stem cells. USP34 expression levels were relatively lower in MDA-MB-231 and 4T1 mesenchymal-like cells when compared to epithelial-like cells. Inhibition of USP34 in NMuMG cells induced EMT, as evidenced by the upregulation of EMT markers including N-cadherin, phospho-Smad3, Snail and active-β-catenin, as well as the downregulation of Axin 1 and E-cadherin...
May 10, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28498481/comparison-of-three-different-methods-for-the-detection-of-circulating-tumor-cells-in-mice-with-lung-metastasis
#17
Weifeng Xu, Bing Wu, Lengxi Fu, Junying Chen, Zeng Wang, Fei Huang, Jinrong Chen, Mei Zhang, Zhenhuan Zhang, Jingan Lin, Ruilong Lan, Ruiqing Chen, Wei Chen, Long Chen, Jinsheng Hong, Weijian Zhang, Yuxiong Ding, Paul Okunieff, Jianhua Lin, Lurong Zhang
Circulating tumor cells (CTCs) represent the key step of cancer cell dissemination. The alteration of CTCs correlates with the treatment outcome and prognosis. To enrich and identify CTCs from billions of blood cells renders a very challenging task, which triggers development of several methods, including lysis of RBC plus negative or positive enrichment using antibodies, and filter membrane or spiral microfluidics to capture CTCs. To compare the advantages of different enrichment methods for CTCs, we utilized the 4T1 breast cancer cells transfected with both green fluorescent protein (GFP) and luciferase to trace CTCs in the experimental lung metastasis model...
May 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28497361/design-and-characterization-of-lisinopril-loaded-superparamagnetic-nanoparticles-as-a-new-contrast-agent-for-in-vitro-in-vivo-mri-imaging-diagnose-the-tumors-and-drug-delivery-system
#18
Sajjad Abbasi Pour, Hamid Reza Shaterian
Superparamagnetic γ-Fe2O3@SiO2@lisinopril (MNPs-Lisinopril) nanoparticles are T2 and T2* negative contrast agents for magnetic resonance imaging. In this work, we report the preparation of lisinopril-coated MNPs for the first time as new T2 and T2* negative contrast agent for in vitro and in vivo MRI imaging and demonstrate the potential it simultaneously for drug delivery system, diagnose the tumors and MRI contrast agent. Measurements on the relaxivities (r1, r2 and r2*) of the MNPs-Lisinopril were determined in deionized water (in vitro)...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28492237/proline-metabolism-supports-metastasis-formation-and-could-be-inhibited-to-selectively-target-metastasizing-cancer-cells
#19
Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F Orth, Catherine Verfaillie, Thomas G P Grünewald, Sarah-Maria Fendt
Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However, how metabolism supports this adaptation of cancer cells is poorly defined. We use 2D versus 3D cultivation to induce a shift in the cellular phenotype of breast cancer cells. We discover that proline catabolism via proline dehydrogenase (Prodh) supports growth of breast cancer cells in 3D culture. Subsequently, we link proline catabolism to in vivo metastasis formation...
May 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28482548/innovative-superparamagnetic-iron-oxide-nanoparticles-coated-with-silica-and-conjugated-with-linoleic-acid-effect-on-tumor-cell-growth-and-viability
#20
Giuliana Muzio, Marta Miola, Sara Ferraris, Marina Maggiora, Elisa Bertone, Maria Paola Puccinelli, Marina Ricci, Ester Borroni, Rosa Angela Canuto, Enrica Verné, Antonia Follenzi
One of the goals for the development of more effective cancer therapies with reduced toxic side effects is the optimization of innovative treatments to selectively kill tumor cells. The use of nanovectors loaded with targeted therapeutic payloads is one of the most investigated strategies. In this paper superparamagnetic iron oxide nanoparticles (SPIONs) coated by a silica shell or uncoated, were functionalized with single-layer and bi-layer conjugated linoleic acid (CLA). Silica was used to protect the magnetic core from oxidation, improve the stability of SPIONs and tailor their surface reactivity...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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