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REVIEW
Martin Andreas, Haran Burri, Fabien Praz, Osama Soliman, Luigi Badano, Manuel Barreiro, João L Cavalcante, Tom de Potter, Torsten Doenst, Kai Friedrichs, Jörg Hausleiter, Nicole Karam, Susheel Kodali, Azeem Latib, Eloi Marijon, Suneet Mittal, Georg Nickenig, Aldo Rinaldi, Piotr Rudzinski, Marco Russo, Christoph Starck, Ralph Stephan von Bardeleben, Nina Wunderlich, José Luis Zamorano, Rebecca T Hahn, Francesco Maisano, Christophe Leclercq
The role of cardiac implantable electronic device (CIED)-related tricuspid regurgitation (TR) is increasingly recognized as an independent clinical entity. Hence, interventional TR treatment options continuously evolve, surgical risk assessment and peri-operative care improve the management of CIED-related TR, and the role of lead extraction is of high interest. Furthermore, novel surgical and interventional tricuspid valve treatment options are increasingly applied to patients suffering from TR associated with or related to CIEDs...
February 1, 2024: European Heart Journal
#22
REVIEW
Victoria Delgado, Nina Ajmone Marsan, Robert O Bonow, Rebecca T Hahn, Russell A Norris, Liesl Zühlke, Michael A Borger
Degenerative mitral regurgitation is a major threat to public health and affects at least 24 million people worldwide, with an estimated 0.88 million disability-adjusted life years and 34,000 deaths in 2019. Improving access to diagnostic testing and to timely curative therapies such as surgical mitral valve repair will improve the outcomes of many individuals. Imaging such as echocardiography and cardiac magnetic resonance allow accurate diagnosis and have provided new insights for a better definition of the most appropriate timing for intervention...
December 7, 2023: Nature Reviews. Disease Primers
#23
REVIEW
Vratika Agarwal, Rebecca Hahn
During the last few years, there has been a substantial shift in efforts to understand and manage secondary or functional tricuspid regurgitation (TR) given its prevalence, adverse prognostic impact, and symptom burden associated with progressive right heart failure. Understanding the pathophysiology of TR and right heart failure is crucial for determining the best treatment strategy and improving outcomes. In this article, we review the complex relationship between right heart structural and hemodynamic changes that drive the pathophysiology of secondary TR and discuss the role of multimodality imaging in the diagnosis, management, and determination of outcomes...
January 2024: Interventional Cardiology Clinics
#24
JOURNAL ARTICLE
Susheel Kodali, Rebecca T Hahn, Raj Makkar, Moody Makar, Charles J Davidson, Jyothy J Puthumana, Firas Zahr, Scott Chadderdon, Neil Fam, Geraldine Ong, Pradeep Yadav, Vinod Thourani, Mani A Vannan, William W O'Neill, Dee Dee Wang, Didier Tchétché, Nicolas Dumonteil, Laurent Bonfils, Laurent Lepage, Robert Smith, Paul A Grayburn, Rahul P Sharma, Christiane Haeffele, Vasilis Babaliaros, Patrick T Gleason, Sammy Elmariah, Ignacio Inglessis-Azuaje, Jonathan Passeri, Howard C Herrmann, Frank E Silvestry, Scott Lim, Dale Fowler, John G Webb, Robert Moss, Thomas Modine, Stephane Lafitte, Azeem Latib, Edwin Ho, Ythan Goldberg, Pinak Shah, Charles Nyman, Josep Rodés-Cabau, Elisabeth Bédard, Nicolas Brugger, Anna Sannino, Michael J Mack, Martin B Leon, Stephan Windecker
BACKGROUND AND AIMS: For patients with symptomatic, severe tricuspid regurgitation (TR), early results of transcatheter tricuspid valve (TV) intervention studies have shown significant improvements in functional status and quality of life associated with right-heart reverse remodelling. Longer-term follow-up is needed to confirm sustained improvements in these outcomes. METHODS: The prospective, single-arm, multicentre TRISCEND study enrolled 176 patients to evaluate the safety and performance of transcatheter TV replacement in patients with ≥moderate, symptomatic TR despite medical therapy...
December 7, 2023: European Heart Journal
#25
JOURNAL ARTICLE
Giulio Russo, Luigi P Badano, Marianna Adamo, Hannes Alessandrini, Martin Andreas, Daniel Braun, Kim A Connelly, Paolo Denti, Rodrigo Estevez-Loureiro, Neil Fam, Mara Gavazzoni, Rebecca T Hahn, Claudia Harr, Joerg Hausleiter, Dominique Himbert, Daniel Kalbacher, Edwin Ho, Azeem Latib, Edith Lubos, Sebastian Ludwig, Philipp Lurz, Vanessa Monivas, Georg Nickenig, Daniela Pedicino, Giovanni Pedrazzini, Alberto Pozzoli, Denise Pires Marafon, Roberta Pastorino, Fabien Praz, Joseph Rodes-Cabau, Christian Besler, Joachim Schofer, Andrea Scotti, Kerstin Piayda, Horst Sievert, Gilbert H L Tang, Holger Thiele, Florian Schlotter, Ralph Stephan von Bardeleben, John Webb, Stephan Windecker, Martin Leon, Francesco Maisano, Marco Metra, Maurizio Taramasso
BACKGROUND: Secondary or functional tricuspid regurgitation (STR) is the most common phenotype of tricuspid regurgitation (TR) with atrial STR (ASTR) and ventricular STR (VSTR) being recently identified as two distinct entities. Data on tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with STR according to phenotype (i.e. ASTR vs VSTR) are lacking. OBJECTIVES: The aim of this study was to assess characteristics and outcomes of patients with ASTR vs VSTR undergoing T-TEER...
October 31, 2023: European Journal of Heart Failure
#26
JOURNAL ARTICLE
Christina Engel Hoei-Hansen, Lene Weber, Mette Johansen, Rebecca Fabricius, Jonas Kjeldbjerg Hansen, Anne-Cathrine F Viuff, Gitte Rønde, Gitte Holst Hahn, Elsebet Østergaard, Morten Duno, Vibeke Andrée Larsen, Camilla Gøbel Madsen, Katrine Røhder, Ann-Kristin Gunnes Elvrum, Britt Laugesen, Melanie Ganz, Kathrine Skak Madsen, Maria Willerslev-Olsen, Nanette Mol Debes, Jan Christensen, Robin Christensen, Gija Rackauskaite
BACKGROUND: Early diagnosis of cerebral palsy (CP) is important to enable intervention at a time when neuroplasticity is at its highest. Current mean age at diagnosis is 13 months in Denmark. Recent research has documented that an early-diagnosis set-up can lower diagnostic age in high-risk infants. The aim of the current study is to lower diagnostic age of CP regardless of neonatal risk factors. Additionally, we want to investigate if an early intervention program added to standard care is superior to standard care alone...
October 30, 2023: BMC Pediatrics
#27
JOURNAL ARTICLE
Lyle Dershowitz, Matthew K Lawlor, Nadira Hamid, Polydoros Kampaktsis, Yuming Ning, Torsten P Vahl, Tamim Nazif, Omar Khalique, Vivian Ng, Paul Kurlansky, Martin Leon, Rebecca Hahn, Susheel Kodali, Isaac George
AIMS: Characterize the impact of residual tricuspid regurgitation (TR) on right ventricle (RV) remodeling and clinical outcomes after transcatheter tricuspid valve intervention. METHODS: We performed a single-center retrospective analysis of transcatheter tricuspid valve repair (TTVr) or replacement (TTVR) patients. The primary outcomes were longitudinal tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulmonary artery systolic pressure (PASP), and RV dimensions (RVd)...
October 27, 2023: Catheterization and Cardiovascular Interventions
#28
JOURNAL ARTICLE
Michael J Mack, Martin B Leon, Vinod H Thourani, Philippe Pibarot, Rebecca T Hahn, Philippe Genereux, Susheel K Kodali, Samir R Kapadia, David J Cohen, Stuart J Pocock, Michael Lu, Roseann White, Molly Szerlip, Julien Ternacle, S Chris Malaisrie, Howard C Herrmann, Wilson Y Szeto, Mark J Russo, Vasilis Babaliaros, Craig R Smith, Philipp Blanke, John G Webb, Raj Makkar
BACKGROUND: A previous analysis in this trial showed that among patients with severe, symptomatic aortic stenosis who were at low surgical risk, the rate of the composite end point of death, stroke, or rehospitalization at 1 year was significantly lower with transcatheter aortic-valve replacement (TAVR) than with surgical aortic-valve replacement. Longer-term outcomes are unknown. METHODS: We randomly assigned patients with severe, symptomatic aortic stenosis and low surgical risk to undergo either TAVR or surgery...
October 24, 2023: New England Journal of Medicine
#29
EDITORIAL
Catherine M Otto, Joanna Bartkowiak, Rebecca T Hahn
No abstract text is available yet for this article.
October 12, 2023: Heart
#30
Rebecca Earnest, Anne M Hahn, Nicole M Feriancek, Matthew Brandt, Renata B Filler, Zhe Zhao, Mallery I Breban, Chantal B F Vogels, Nicholas F G Chen, Robert T Koch, Abbey J Porzucek, Afeez Sodeinde, Alexa Garbiel, Claire Keanna, Hannah Litwak, Heidi R Stuber, Jamie L Cantoni, Virginia E Pitzer, Ximena A Olarte Castillo, Laura B Goodman, Craig B Wilen, Megan A Linske, Scott C Williams, Nathan D Grubaugh
Diverse mammalian species display susceptibility to and infection with SARS-CoV-2. Potential SARS-CoV-2 spillback into rodents is understudied despite their host role for numerous zoonoses and human proximity. We assessed exposure and infection among white-footed mice ( Peromyscus leucopus ) in Connecticut, USA. We observed 1% (6/540) wild-type neutralizing antibody seroprevalence among 2020-2022 residential mice with no cross-neutralization of variants. We detected no SARS-CoV-2 infections via RT-qPCR, but identified non-SARS-CoV-2 betacoronavirus infections via pan-coronavirus PCR among 1% (5/468) of residential mice...
September 27, 2023: bioRxiv
#31
Rebecca M Hurwitz, Georg Hahn
Principal components computed via PCA (principal component analysis) are traditionally used to reduce dimensionality in genomic data or to correct for population stratification. In this paper, we explore the penalized eigenvalue problem (PEP) which reformulates the computation of the first eigenvector as an optimization problem and adds an L1 penalty constraint. The contribution of our article is threefold. First, we extend PEP by applying Nesterov smoothing to the original LASSO-type L1 penalty. This allows one to compute analytical gradients which enable faster and more efficient minimization of the objective function associated with the optimization problem...
September 25, 2023: ArXiv
#32
JOURNAL ARTICLE
Irfan Zeb, Raafay Uqaily, Karthik Gonuguntla, Dipesh Ludhwani, Ahmed Abdelhaleem, Jonathon Leipsic, Rebecca T Hahn, Philippe Pibarot, Kesavan Sankaramangalam, Dhivya Kuzhandai, Yasar Sattar, Sameer Raina, Balla Sudarshan, Mohammad Kawsara, Yasmin Hamirani, Ramesh Daggubati
BACKGROUND: Aortic valve area (AVA) using CT-LVOT area (AVACT-LVOT ) <1.2 cm2 has been shown comparable to echocardiography AVA of <1.0 cm2 for severe aortic stenosis (AS). Current study evaluates how AS diagnosis will be affected when we substitute CT-LVOT with echo derived LVOT. METHODS: We retrospectively studied 367 patients who underwent cardiac CTA and echocardiogram for assessment of high- and low-gradient AS (HG-AS and LG-AS)...
October 6, 2023: Journal of Cardiovascular Computed Tomography
#33
REVIEW
Rebecca T Hahn, Matthew K Lawlor, Charles J Davidson, Vinay Badhwar, Anna Sannino, Ernest Spitzer, Philipp Lurz, Brian R Lindman, Yan Topilsky, Suzanne J Baron, Scott Chadderdon, Omar K Khalique, Gilbert H L Tang, Maurizio Taramasso, Paul A Grayburn, Luigi Badano, Jonathon Leipsic, JoAnn Lindenfeld, Stephan Windecker, Sreekanth Vemulapalli, Bjorn Redfors, Maria C Alu, David J Cohen, Josep Rodés-Cabau, Gorav Ailawadi, Michael Mack, Ori Ben-Yehuda, Martin B Leon, Jörg Hausleiter
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR...
October 24, 2023: Journal of the American College of Cardiology
#34
REVIEW
Rebecca T Hahn, Matthew K Lawlor, Charles J Davidson, Vinay Badhwar, Anna Sannino, Ernest Spitzer, Philipp Lurz, Brian R Lindman, Yan Topilsky, Suzanne J Baron, Scott Chadderdon, Omar K Khalique, Gilbert H L Tang, Maurizio Taramasso, Paul A Grayburn, Luigi Badano, Jonathon Leipsic, JoAnn Lindenfeld, Stephan Windecker, Sreekanth Vemulapalli, Bjorn Redfors, Maria C Alu, David J Cohen, Josep Rodés-Cabau, Gorav Ailawadi, Michael Mack, Ori Ben-Yehuda, Martin B Leon, Jörg Hausleiter
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR...
November 2023: Annals of Thoracic Surgery
#35
JOURNAL ARTICLE
Rebecca T Hahn, Matthew K Lawlor, Charles J Davidson, Vinay Badhwar, Anna Sannino, Ernest Spitzer, Philipp Lurz, Brian R Lindman, Yan Topilsky, Suzanne J Baron, Scott Chadderdon, Omar K Khalique, Gilbert H L Tang, Maurizio Taramasso, Paul A Grayburn, Luigi Badano, Jonathon Leipsic, JoAnn Lindenfeld, Stephan Windecker, Sreekanth Vemulapalli, Bjorn Redfors, Maria C Alu, David J Cohen, Josep Rodés-Cabau, Gorav Ailawadi, Michael Mack, Ori Ben-Yehuda, Martin B Leon, Jörg Hausleiter
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR...
November 14, 2023: European Heart Journal
#36
JOURNAL ARTICLE
Maren M Sjaastad Andreassen, Stephane Loubrie, Michelle W Tong, Lauren Fang, Tyler M Seibert, Anne M Wallace, Somaye Zare, Haydee Ojeda-Fournier, Joshua Kuperman, Michael Hahn, Neil P Jerome, Tone F Bathen, Ana E Rodríguez-Soto, Anders M Dale, Rebecca Rakow-Penner
PURPOSE: Dynamic contrast-enhanced MRI (DCE) and apparent diffusion coefficient (ADC) are currently used to evaluate treatment response of breast cancer. The purpose of the current study was to evaluate the three-component Restriction Spectrum Imaging model (RSI3C ), a recent diffusion-weighted MRI (DWI)-based tumor classification method, combined with elastic image registration, to automatically monitor breast tumor size throughout neoadjuvant therapy. EXPERIMENTAL DESIGN: Breast cancer patients ( n= 27) underwent multi-parametric 3T MRI at four time points during treatment...
2023: Frontiers in Oncology
#37
MULTICENTER STUDY
Mayra E Guerrero, Mackram F Eleid, Dee Dee Wang, Amit Pursnani, Susheel K Kodali, Isaac George, Igor Palacios, Hyde Russell, Raj R Makkar, Saibal Kar, Lowell F Satler, Vivek Rajagopal, George Dangas, Gilbert H L Tang, James M McCabe, Brian K Whisenant, Kenith Fang, Prakash Balan, Richard Smalling, Tatiana Kaptzan, Bradley Lewis, Pamela S Douglas, Rebecca T Hahn, Jeremy Thaden, Jae K Oh, Martin Leon, William O'Neill, Charanjit Rihal
BACKGROUND: The MITRAL (Mitral Implantation of Transcatheter Valves) trial is the first prospective trial to evaluate the safety and feasibility of balloon-expandable aortic transcatheter heart valves in patients with failed surgical bioprostheses or annuloplasty rings and severe mitral annular calcification treated with mitral valve-in-valve (MViV), valve-in-ring (MViR), or valve-in-mitral annular calcification (ViMAC). OBJECTIVES: The aim of this study was to evaluate 5-year outcomes among these patients...
September 25, 2023: JACC. Cardiovascular Interventions
#38
REVIEW
Mark Lebehn, Torsten Vahl, Polydoros Kampaktsis, Rebecca T Hahn
Aortic regurgitation (AR) is the third most frequent form of valvular disease and has increasing prevalence with age. This will be of increasing clinical importance with the advancing age of populations around the globe. An understanding of the various etiologies and mechanisms leading to AR requires a detailed understanding of the structure of the aortic valve and aortic root. While acute and chronic AR may share a similar etiology, their hemodynamic impact on the left ventricle (LV) and management are very different...
August 25, 2023: Journal of Cardiovascular Development and Disease
#39
REVIEW
Julia Grapsa, Fabien Praz, Paul Sorajja, Joao L Cavalcante, Marta Sitges, Maurizio Taramasso, Nicolo Piazza, David Messika-Zeitoun, Hector I Michelena, Nadira Hamid, Julien Dreyfus, Giovanni Benfari, Edgar Argulian, Alaide Chieffo, Didier Tchetche, Lawrence Rudski, Jeroen J Bax, Ralph Stephan von Bardeleben, Tiffany Patterson, Simon Redwood, Vinayak N Bapat, Georg Nickenig, Philipp Lurz, Jörg Hausleiter, Susheel Kodali, Rebecca T Hahn, Francesco Maisano, Maurice Enriquez-Sarano
Tricuspid regurgitation (TR) is a highly prevalent and heterogeneous valvular disease, independently associated with excess mortality and high morbidity in all clinical contexts. TR is profoundly undertreated by surgery and is often discovered late in patients presenting with right-sided heart failure. To address the issue of undertreatment and poor clinical outcomes without intervention, numerous structural tricuspid interventional devices have been and are in development, a challenging process due to the unique anatomic and physiological characteristics of the tricuspid valve, and warranting well-designed clinical trials...
January 2024: JACC. Cardiovascular Imaging
#40
REVIEW
Vratika Agarwal, Rebecca Hahn
During the last few years, there has been a substantial shift in efforts to understand and manage secondary or functional tricuspid regurgitation (TR) given its prevalence, adverse prognostic impact, and symptom burden associated with progressive right heart failure. Understanding the pathophysiology of TR and right heart failure is crucial for determining the best treatment strategy and improving outcomes. In this article, we review the complex relationship between right heart structural and hemodynamic changes that drive the pathophysiology of secondary TR and discuss the role of multimodality imaging in the diagnosis, management, and determination of outcomes...
October 2023: Heart Failure Clinics
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