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Rebecca Hahn

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https://www.readbyqxmd.com/read/28430909/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#1
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28427598/computed-tomography-based-oversizing-degrees-and-incidence-of-paravalvular-regurgitation-of-a-new-generation-transcatheter-heart-valve
#2
Philipp Blanke, Philippe Pibarot, Rebecca Hahn, Neil Weissman, Susheel Kodali, Vinod Thourani, Rupa Parvataneni, Danny Dvir, Christopher Naoum, Bjarne L Nørgaard, Pamela Douglas, Wael Jaber, Omar K Khalique, Hasan Jilaihawi, Michael Mack, Craig Smith, Martin Leon, John Webb, Jonathon Leipsic
OBJECTIVES: The aim of the study was to investigate the influence of the extent of computed tomography (CT)-based area and perimeter oversizing on the incidence and severity of paravalvular aortic regurgitation (PAR) for the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) device, using CT data and echocardiographic outcome data of the PARTNER II (Placement of AoRTic TraNscathetER Valves Trial II) SAPIEN 3 intermediate-risk cohort. BACKGROUND: Transcatheter heart valve (THV) sizing algorithms are device specific, requiring refinements for new valve designs...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28427582/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#3
REVIEW
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28385308/early-feasibility-study-of-a-transcatheter%C3%A2-tricuspid-valve-annuloplasty-scout-trial-30-day%C3%A2-results
#4
Rebecca T Hahn, Christopher U Meduri, Charles J Davidson, Scott Lim, Tamim M Nazif, Mark J Ricciardi, Vivek Rajagopal, Gorav Ailawadi, Mani A Vannan, James D Thomas, Dale Fowler, Stuart Rich, Randy Martin, Geraldine Ong, Adam Groothuis, Susheel Kodali
BACKGROUND: The SCOUT (Percutaneous Tricuspid Valve Annuloplasty System for Symptomatic Chronic Functional Tricuspid Regurgitation) trial is a prospective, single-arm, multicenter, early feasibility study of a novel transcatheter device to plicate the tricuspid annulus (TA) and reduce tricuspid regurgitation (TR). OBJECTIVES: This study tested the feasibility and safety of a novel transcatheter device and assessed its early performance and functional outcomes. METHODS: Between November 2015 and June 2016, 15 patients with New York Heart Association (NYHA) functional class ≥II and moderate or greater functional TR were enrolled...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28330659/use-of-echocardiography-for-guiding-percutaneous-tricuspid-valve-procedures
#5
Eustachio Agricola, Francesco Ancona, Stefano Stella, Isabella Rosa, Claudia Marini, Marco Spartera, Paolo Denti, Alberto Margonato, Rebecca T Hahn, Ottavio Alfieri, Antonio Colombo, Azeem Latib
No abstract text is available yet for this article.
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28314623/recommendations-for-noninvasive-evaluation-of-native-valvular-regurgitation-a-report-from-the-american-society-of-echocardiography-developed-in-collaboration-with-the-society-for-cardiovascular-magnetic-resonance
#6
William A Zoghbi, David Adams, Robert O Bonow, Maurice Enriquez-Sarano, Elyse Foster, Paul A Grayburn, Rebecca T Hahn, Yuchi Han, Judy Hung, Roberto M Lang, Stephen H Little, Dipan J Shah, Stanton Shernan, Paaladinesh Thavendiranathan, James D Thomas, Neil J Weissman
No abstract text is available yet for this article.
March 13, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28280546/chimpanzees-breed-with-genetically-dissimilar-mates
#7
Kara K Walker, Rebecca S Rudicell, Yingying Li, Beatrice H Hahn, Emily Wroblewski, Anne E Pusey
Inbreeding adversely affects fitness, whereas heterozygosity often augments it. Therefore, mechanisms to avoid inbreeding and increase genetic distance between mates should be advantageous in species where adult relatives reside together. Here we investigate mate choice for genetic dissimilarity in chimpanzees, a species in which many females avoid inbreeding through dispersal, but where promiscuous mating and sexual coercion can limit choice when related adults reside together. We take advantage of incomplete female dispersal in Gombe National Park, Tanzania to compare mate choice for genetic dissimilarity among immigrant and natal females in two communities using pairwise relatedness measures in 135 genotyped chimpanzees...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28240518/the-challenge-of-preoperative-quantification-of-functional-tricuspid-regurgitation-and-of-right-ventricle-function-what-information-is-clinically-relevant
#8
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) is the most common etiology of severe TR in the western world. The presence of functional TR, either isolated or in combination with left heart disease is associated with unfavorable natural history however surgical mortality for isolated tricuspid valve interventions remain higher than for any other single valve surgery. Determining the severity of TR remains a controversial area and will continue to evolve as new techniques for assessing this valve as well as the right ventricle, are investigated...
February 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28219920/impact-of-coronary-artery-disease-severity-assessed-with-the-syntax-score-on-outcomes-following-transcatheter-aortic-valve-replacement
#9
Jean-Michel Paradis, Jonathon M White, Philippe Généreux, Marina Urena, Darshan Doshi, Tamim Nazif, Rebecca Hahn, Isaac George, Omar Khalique, Kishore Harjai, Laura Lasalle, Benoit M Labbé, Robert DeLarochellière, Daniel Doyle, Éric Dumont, Siamak Mohammadi, Martin B Leon, Josep Rodés-Cabau, Susheel Kodali
BACKGROUND: The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. METHODS AND RESULTS: A total of 377 patients who underwent TAVR in 2 high-volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28177281/copy-number-and-gene-dependency-analysis-reveals-partial-copy-loss-of-wild-type-sf3b1-as-a-novel-cancer-vulnerability
#10
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number associated gene dependencies). The most enriched class of copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS) genes, and spliceosome components were the most prevalent...
February 8, 2017: ELife
https://www.readbyqxmd.com/read/28039322/injuries-to-the-aorta-aortic-annulus-and-left-ventricle-during-transcatheter-aortic-valve-replacement-management-and-outcomes
#11
Nathaniel B Langer, Nadira B Hamid, Tamim M Nazif, Omar K Khalique, Torsten P Vahl, Jonathon White, Juan Terre, Ramin Hastings, Diana Leung, Rebecca T Hahn, Martin Leon, Susheel Kodali, Isaac George
The experience with transcatheter aortic valve replacement is increasing worldwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not decreased. In most cases, significant injuries to the aorta, aortic valve annulus, and left ventricle require open surgical repair. However, the transcatheter aortic valve replacement patient presents a unique challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgical procedure may not be feasible or appropriate...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28017714/long-term-valve-performance-of-tavr-and-savr-a-report-from-the-partner-i-trial
#12
Melissa A Daubert, Neil J Weissman, Rebecca T Hahn, Philippe Pibarot, Rupa Parvataneni, Michael J Mack, Lars G Svensson, Deepika Gopal, Samir Kapadia, Robert J Siegel, Susheel K Kodali, Wilson Y Szeto, Raj Makkar, Martin B Leon, Pamela S Douglas
OBJECTIVES: The aim of this study was to evaluate the long-term performance of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) through longitudinal echocardiographic analysis. BACKGROUND: The long-term performance of the SAPIEN TAVR is not well-described. Therefore, we examined the hemodynamic and valvular profile of the SAPIEN TAVR over 5 years. METHODS: All patients receiving TAVR or SAVR with first post-implant (FPI) and 5-year echoes were analyzed for aortic valve (AV) peak velocity, AV mean gradient, AV area, peak left ventricular (LV) outflow tract and in-stent velocities, Doppler velocity index, aortic regurgitation (AR), LV mass index, stroke volume index, and cardiac index...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27986555/serological-approaches-for-the-diagnosis-of-schistosomiasis-a-review
#13
Rebecca Hinz, Norbert G Schwarz, Andreas Hahn, Hagen Frickmann
Schistosomiasis is a common disease in endemic areas of Sub-Saharan Africa, South America and Asia. It is rare in Europe, mainly imported from endemic countries due to travelling or human migration. Available methods for the diagnosis of schistosomiasis comprise microscopic, molecular and serological approaches, with the latter detecting antigens or antibodies associated with Schistosoma spp. infection. The serological approach is a valuable screening tool in low-endemicity settings and for travel medicine, though the interpretation of any diagnostic results requires knowledge of test characteristics and a patient's history...
December 13, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27974407/state-of-the-art-review-of-echocardiographic-imaging-in-the-evaluation-and-treatment-of-functional-tricuspid-regurgitation
#14
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) is the most common cause of severe TR in the Western world. The presence of functional TR, either isolated or in combination with left heart disease, is associated with unfavorable natural history. Surgical mortality for isolated tricuspid valve interventions remains higher than for any other single valve surgery, and surgical options for repair do not have consistent long-term durability. In addition, as more patients undergo transcatheter left valve interventions, developing transcatheter solutions for functional TR has gained greater momentum...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27970251/tct-86-early-experience-with-the-trialign-system-for-transcatheter-tricuspid-valve-repair-a-multicenter-experience
#15
Ermela Yzeiraj, Horst Sievert, Georg Nickenig, Azeem Latib, Rebecca Hahn, Joachim Schofer
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970209/tct-819-clinical-outcome-in-patients-with-heart-failure-and-moderate-aortic-stenosis
#16
Lennart van Gils, Marie-Annick Clavel, Mara Vollema, Victoria Delgado, Tamim Nazif, Ernest Spitzer, Rebecca Hahn, Jeroen Bax, Martin Leon, Philippe Pibarot, Nicolas Van Mieghem
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970151/tct-77-association-of-residual-mitral-regurgitation-after-transcatheter-aortic-valve-replacement-with-readmission-for-acute-heart-failure-an-analysis-from-partner-1
#17
John Petersen, Eugene Blackstone, Jeevanantham Rajeswaran, David Cohen, Pamela Douglas, Rebecca Hahn, Susheel Kodali, Lars Svensson, Martin Leon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970078/tct-699-anatomic-deployment-index-a-novel-measure-of-sapien-3-transcatheter%C3%A2-heart-valve-performance
#18
Rebecca Hahn, Maria Alu, Jonathon Leipsic, Pamela Douglas, Wael Jaber, Neil Weissman, Omar Khalique, Philipp Blanke, Rupa Parvataneni, Susheel Kodali, Vinod Thourani, Philippe Pibarot
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970068/tct-691-sex-specific-differences-after-transcatheter-or-surgical-aortic-valve-replacement-in-intermediate-risk-patients-an-analysis-from-the-partner-2-randomized-trial
#19
Jonathan White, Darshan Doshi, Mathew Williams, Molly Szerlip, John Squiers, John Webb, Rebecca Hahn, Ajay Kirtane, Claire Litherland, David Cohen, E Murat Tuzcu, Wilson Szeto, Alan Zajarias, S Chris Malaisrie, Maria Alu, Craig Smith, Martin Leon, Michael Mack, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970058/tct-679-diabetes-and-clinical-outcomes-in-intermediate-risk-patients-randomized-to-transcatheter-versus-surgical-aortic-valve-replacement-an-analysis-of-the-partner-2a-trial
#20
Brian Lindman, Yigal Abramowitz, Philippe Pibarot, Nishath Quader, Hersh Maniar, Alan Zajarias, Suzanne Arnold, Rebecca Hahn, Sammy Elmariah, Rakesh Suri, Torsten Vahl, Lars Svensson, Vinod Thourani, Claire Litherland, Maria Alu, Martin Leon, Raj Makkar
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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