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Rebecca Hahn

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https://www.readbyqxmd.com/read/28751491/pediatric-chronic-critical-illness-reducing-excess-hospitalizations
#1
Renee D Boss, Erin P Williams, Carrie M Henderson, Rebecca R Seltzer, Miriam C Shapiro, Emily Hahn, Nancy Hutton
OBJECTIVES: The past 2 decades have seen an expanding pediatric population that is chronically critically ill: children with repeated and prolonged hospitalizations and ongoing dependence on technologies to sustain vital functions. Although illness complexity prompts many hospitalizations, our goal with this study was to explore modifiable patient, family, and health system contributions to excess hospital days for children with chronic critical illness (CCI). METHODS: Semistructured interviews were conducted with 51 stakeholders known for their CCI expertise...
July 27, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28734891/ct-defined-prosthesis-patient-mismatch-downgrades-frequency-and-severity-and%C3%A2-demonstrates-no-association-with-adverse-outcomes-after-tavr
#2
John Mooney, Stephanie L Sellers, Phillip Blanke, Philippe Pibarot, Rebecca T Hahn, Danny Dvir, Pamela S Douglas, Neil J Weissman, Susheel K Kodali, Vinod H Thourani, Hasan Jilaihawi, Omar Khalique, Craig R Smith, Shaw Hua Kueh, Mickael Ohana, Romi Grover, Christopher Naoum, Aaron Crowley, Wael A Jaber, Maria C Alu, Rupa Parvataneni, Michael Mack, John G Webb, Martin B Leon, Jonathon A Leipsic
OBJECTIVES: This study sought to determine if indexed effective orifice area (EOAi), using left ventricular outflow tract measured from computed tomography (EOAiCT), reclassified prosthesis-patient mismatch (PPM) compared with conventional echocardiogram-defined measurements (EOAiTTE). BACKGROUND: PPM does not predict mortality following transcatheter aortic valve replacement (TAVR). However, it is unknown if the EOAiCT of the left ventricular outflow tract improves risk stratification...
July 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28706866/current-transcatheter-devices-to-treat-functional-tricuspid-regurgitation-with-discussion-of-issues-relevant-to-clinical-trial-design
#3
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) has seen increased attention in recent times as relationships with clinically-relevant outcomes have come to light. Despite the association of increased mortality with significant TR, the disease remains under-recognized and thus relatively untreated. In addition, the disease itself has not been extensively studied and the interactions between annular dilatation, right heart disease and pulmonary hypertension are poorly understood. However, the high mortality and recurrence rate with current surgical replacement or repair techniques is well recognised, opening the door to transcatheter therapies for functional TR...
May 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28701528/blood-pressure-and-arterial-load-after-transcatheter-aortic-valve-replacement-for-aortic-stenosis
#4
MULTICENTER STUDY
Brian R Lindman, Catherine M Otto, Pamela S Douglas, Rebecca T Hahn, Sammy Elmariah, Neil J Weissman, William J Stewart, Girma M Ayele, Feifan Zhang, Alan Zajarias, Hersh S Maniar, Hasan Jilaihawi, Eugene Blackstone, Khaja M Chinnakondepalli, E Murat Tuzcu, Martin B Leon, Philippe Pibarot
BACKGROUND: After aortic valve replacement, left ventricular afterload is often characterized by the residual valve obstruction. Our objective was to determine whether higher systemic arterial afterload-as reflected in blood pressure, pulsatile and resistive load-is associated with adverse clinical outcomes after transcatheter aortic valve replacement (TAVR). METHODS AND RESULTS: Total, pulsatile, and resistive arterial load were measured in 2141 patients with severe aortic stenosis treated with TAVR in the PARTNER I trial (Placement of Aortic Transcatheter Valve) who had systolic blood pressure (SBP) and an echocardiogram obtained 30 days after TAVR...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28608869/an-ecoregion-based-approach-to-protecting-half-the-terrestrial-realm
#5
COMMENT
Eric Dinerstein, David Olson, Anup Joshi, Carly Vynne, Neil D Burgess, Eric Wikramanayake, Nathan Hahn, Suzanne Palminteri, Prashant Hedao, Reed Noss, Matt Hansen, Harvey Locke, Erle C Ellis, Benjamin Jones, Charles Victor Barber, Randy Hayes, Cyril Kormos, Vance Martin, Eileen Crist, Wes Sechrest, Lori Price, Jonathan E M Baillie, Don Weeden, Kierán Suckling, Crystal Davis, Nigel Sizer, Rebecca Moore, David Thau, Tanya Birch, Peter Potapov, Svetlana Turubanova, Alexandra Tyukavina, Nadia de Souza, Lilian Pintea, José C Brito, Othman A Llewellyn, Anthony G Miller, Annette Patzelt, Shahina A Ghazanfar, Jonathan Timberlake, Heinz Klöser, Yara Shennan-Farpón, Roeland Kindt, Jens-Peter Barnekow Lillesø, Paulo van Breugel, Lars Graudal, Maianna Voge, Khalaf F Al-Shammari, Muhammad Saleem
We assess progress toward the protection of 50% of the terrestrial biosphere to address the species-extinction crisis and conserve a global ecological heritage for future generations. Using a map of Earth's 846 terrestrial ecoregions, we show that 98 ecoregions (12%) exceed Half Protected; 313 ecoregions (37%) fall short of Half Protected but have sufficient unaltered habitat remaining to reach the target; and 207 ecoregions (24%) are in peril, where an average of only 4% of natural habitat remains. We propose a Global Deal for Nature-a companion to the Paris Climate Deal-to promote increased habitat protection and restoration, national- and ecoregion-scale conservation strategies, and the empowerment of indigenous peoples to protect their sovereign lands...
June 1, 2017: Bioscience
https://www.readbyqxmd.com/read/28557480/patient-reported-outcome-measures-in-huntington-disease-quality-of-life-in-neurological-disorders-neuro-qol-social-functioning-measures
#6
Noelle E Carlozzi, Elizabeth A Hahn, Siera M Goodnight, Anna L Kratz, Jane S Paulsen, Julie C Stout, Samuel Frank, Jennifer A Miner, David Cella, Richard C Gershon, Stephen G Schilling, Rebecca E Ready
Social functioning is an essential but poorly understood component of health-related quality of life (HRQOL) for people with Huntington disease (HD). We report on the psychometric properties of 2 Neuro-QoL patient-reported outcome measures to assess social functioning in HD. Persons with prodromal (n = 198) or manifest HD (n = 195 early and n = 117 late) completed Neuro-QoL Ability to Participate in Social Roles and Activities, and Satisfaction with Social Roles and Activities. Items from 2 generic HRQOL patient-reported outcome measures were used to create a social functioning composite score; items from the Unified Huntington's Disease Rating Scale and Problem Behaviors Assessment Scale were used to create a clinician-rated composite score of social function...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28556412/patient-reported-outcomes-in-huntington-s-disease-quality-of-life-in-neurological-disorders-neuro-qol-and-huntington-s-disease-health-related-quality-of-life-hdqlife-physical-function-measures
#7
Noelle E Carlozzi, Rebecca E Ready, Samuel Frank, David Cella, Elizabeth A Hahn, Siera M Goodnight, Stephen G Schilling, Nicholas R Boileau, Praveen Dayalu
BACKGROUND: There is a need for patient-reported outcome measures that capture the impact that motor impairments have on health-related quality of life in individuals with Huntington's disease. OBJECTIVES: The objectives of this study were to establish the reliability and validity of new physical functioning patient-reported outcome measures in Huntington's disease. METHODS: A total of 510 individuals with Huntington's disease completed 2 Quality of Life in Neurological Disorders (Lower Extremity Function and Upper Extremity Function) and 3 Huntington's Disease Health-Related Quality of Life (Chorea, Speech Difficulties, and Swallowing Difficulties) measures...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28494976/prognostic-implications-of-moderate-aortic%C3%A2-stenosis-in-patients-with-left%C3%A2-ventricular-systolic%C3%A2-dysfunction
#8
MULTICENTER STUDY
Lennart van Gils, Marie-Annick Clavel, E Mara Vollema, Rebecca T Hahn, Ernest Spitzer, Victoria Delgado, Tamim Nazif, Peter P De Jaegere, Marcel L Geleijnse, Ori Ben-Yehuda, Jeroen J Bax, Martin B Leon, Philippe Pibarot, Nicolas M Van Mieghem
BACKGROUND: Left ventricular (LV) systolic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexist. Afterload reduction is the mainstay of pharmacological treatment of heart failure (HF). Aortic valve replacement (AVR) is only formally indicated for symptomatic severe AS. OBJECTIVES: This study sought to determine the clinical outcome of patients with concomitant moderate AS and LV systolic dysfunction. METHODS: Echocardiographic and clinical data of patients with moderate AS and LV systolic dysfunction between 2010 and 2015 from 4 large academic institutions were retrospectively analyzed...
May 16, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28487320/aortic-valve-annular-sizing-intraoperative-assessment-versus-preoperative-multidetector-computed-tomography
#9
COMPARATIVE STUDY
Isaac George, Laura C Guglielmetti, Nicolas Bettinger, Andrew Moss, Catherine Wang, Nathan Kheysin, Rebecca Hahn, Susheel Kodali, Martin Leon, Vinayak Bapat, Michael A Borger, Mathew Williams, Craig Smith, Omar K Khalique
BACKGROUND: Appropriate valve sizing is critical in aortic valve replacement. We hypothesized that direct intraoperative valve sizing results in smaller aortic annular diameters compared with sizing based on systolic-phase multidetector computerized tomographic (MDCT) imaging. METHODS AND RESULTS: We retrospectively analyzed 78 patients undergoing surgical aortic valve replacement for severe aortic stenosis between 2012 and 2014 at our institution. Preoperative MDCT measurements of the aortic annulus served as basis for assignment to a theoretical surgical valve size, which was then (1) compared to the implanted valve size and (2) to a theoretical transcatheter aortic valve replacement valve size...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28470996/impact-of-small-prosthesis-size-on-transcatheter-or-surgical-aortic-valve-replacement-outcomes
#10
Michael Salna, Omar K Khalique, Codruta Chiuzan, Paul Kurlansky, Michael A Borger, Rebecca T Hahn, Martin B Leon, Craig R Smith, Susheel K Kodali, Isaac George
OBJECTIVES: Determine the comparative impact of small prosthesis size on transcatheter and surgical aortic valve replacement (SAVR) outcomes. BACKGROUND: Patients with small aortic annuli tend to have worse postoperative outcomes and hemodynamics. We sought to describe surgical outcomes in patients with very small aortic annuli and then compare early hemodynamic and clinical outcomes in patients undergoing surgical or transcatheter aortic valve replacement (TAVR) with the smallest available valves to assist in optimal prosthesis selection for this challenging patient population...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28457950/practical-determination-of-aortic-valve-calcium-volume-score-on-contrast-enhanced-computed-tomography-prior-to-transcatheter-aortic-valve-replacement-and-impact-on-paravalvular-regurgitation-elucidating-optimal-threshold-cutoffs
#11
Nicolas Bettinger, Omar K Khalique, Joseph M Krepp, Nadira B Hamid, David J Bae, Todd C Pulerwitz, Ming Liao, Rebecca T Hahn, Torsten P Vahl, Tamim M Nazif, Isaac George, Martin B Leon, Andrew J Einstein, Susheel K Kodali
BACKGROUND: The threshold for the optimal computed tomography (CT) number in Hounsfield Units (HU) to quantify aortic valvular calcium on contrast-enhanced scans has not been standardized. Our aim was to find the most accurate threshold to predict paravalvular regurgitation (PVR) after transcatheter aortic valve replacement (TAVR). METHODS: 104 patients who underwent TAVR with the CoreValve prosthesis were studied retrospectively. Luminal attenuation (LA) in HU was measured at the level of the aortic annulus...
July 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28430909/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#12
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28427598/computed-tomography-based-oversizing-degrees-and-incidence-of-paravalvular-regurgitation-of-a-new-generation-transcatheter-heart-valve
#13
Philipp Blanke, Philippe Pibarot, Rebecca Hahn, Neil Weissman, Susheel Kodali, Vinod Thourani, Rupa Parvataneni, Danny Dvir, Christopher Naoum, Bjarne L Nørgaard, Pamela Douglas, Wael Jaber, Omar K Khalique, Hasan Jilaihawi, Michael Mack, Craig Smith, Martin Leon, John Webb, Jonathon Leipsic
OBJECTIVES: The aim of the study was to investigate the influence of the extent of computed tomography (CT)-based area and perimeter oversizing on the incidence and severity of paravalvular aortic regurgitation (PAR) for the Edwards SAPIEN 3 (Edwards Lifesciences, Irvine, California) device, using CT data and echocardiographic outcome data of the PARTNER II (Placement of AoRTic TraNscathetER Valves Trial II) SAPIEN 3 intermediate-risk cohort. BACKGROUND: Transcatheter heart valve (THV) sizing algorithms are device specific, requiring refinements for new valve designs...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28427582/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#14
REVIEW
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28385308/early-feasibility-study-of-a-transcatheter%C3%A2-tricuspid-valve-annuloplasty-scout-trial-30-day%C3%A2-results
#15
Rebecca T Hahn, Christopher U Meduri, Charles J Davidson, Scott Lim, Tamim M Nazif, Mark J Ricciardi, Vivek Rajagopal, Gorav Ailawadi, Mani A Vannan, James D Thomas, Dale Fowler, Stuart Rich, Randy Martin, Geraldine Ong, Adam Groothuis, Susheel Kodali
BACKGROUND: The SCOUT (Percutaneous Tricuspid Valve Annuloplasty System for Symptomatic Chronic Functional Tricuspid Regurgitation) trial is a prospective, single-arm, multicenter, early feasibility study of a novel transcatheter device to plicate the tricuspid annulus (TA) and reduce tricuspid regurgitation (TR). OBJECTIVES: This study tested the feasibility and safety of a novel transcatheter device and assessed its early performance and functional outcomes. METHODS: Between November 2015 and June 2016, 15 patients with New York Heart Association (NYHA) functional class ≥II and moderate or greater functional TR were enrolled...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28330659/use-of-echocardiography-for-guiding-percutaneous-tricuspid-valve-procedures
#16
Eustachio Agricola, Francesco Ancona, Stefano Stella, Isabella Rosa, Claudia Marini, Marco Spartera, Paolo Denti, Alberto Margonato, Rebecca T Hahn, Ottavio Alfieri, Antonio Colombo, Azeem Latib
No abstract text is available yet for this article.
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28314623/recommendations-for-noninvasive-evaluation-of-native-valvular-regurgitation-a-report-from-the-american-society-of-echocardiography-developed-in-collaboration-with-the-society-for-cardiovascular-magnetic-resonance
#17
William A Zoghbi, David Adams, Robert O Bonow, Maurice Enriquez-Sarano, Elyse Foster, Paul A Grayburn, Rebecca T Hahn, Yuchi Han, Judy Hung, Roberto M Lang, Stephen H Little, Dipan J Shah, Stanton Shernan, Paaladinesh Thavendiranathan, James D Thomas, Neil J Weissman
No abstract text is available yet for this article.
April 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28280546/chimpanzees-breed-with-genetically-dissimilar-mates
#18
Kara K Walker, Rebecca S Rudicell, Yingying Li, Beatrice H Hahn, Emily Wroblewski, Anne E Pusey
Inbreeding adversely affects fitness, whereas heterozygosity often augments it. Therefore, mechanisms to avoid inbreeding and increase genetic distance between mates should be advantageous in species where adult relatives reside together. Here we investigate mate choice for genetic dissimilarity in chimpanzees, a species in which many females avoid inbreeding through dispersal, but where promiscuous mating and sexual coercion can limit choice when related adults reside together. We take advantage of incomplete female dispersal in Gombe National Park, Tanzania to compare mate choice for genetic dissimilarity among immigrant and natal females in two communities using pairwise relatedness measures in 135 genotyped chimpanzees...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28240518/the-challenge-of-preoperative-quantification-of-functional-tricuspid-regurgitation-and-of-right-ventricle-function-what-information-is-clinically-relevant
#19
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) is the most common etiology of severe TR in the western world. The presence of functional TR, either isolated or in combination with left heart disease is associated with unfavorable natural history however surgical mortality for isolated tricuspid valve interventions remain higher than for any other single valve surgery. Determining the severity of TR remains a controversial area and will continue to evolve as new techniques for assessing this valve as well as the right ventricle, are investigated...
February 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28219920/impact-of-coronary-artery-disease-severity-assessed-with-the-syntax-score-on-outcomes-following-transcatheter-aortic-valve-replacement
#20
Jean-Michel Paradis, Jonathon M White, Philippe Généreux, Marina Urena, Darshan Doshi, Tamim Nazif, Rebecca Hahn, Isaac George, Omar Khalique, Kishore Harjai, Laura Lasalle, Benoit M Labbé, Robert DeLarochellière, Daniel Doyle, Éric Dumont, Siamak Mohammadi, Martin B Leon, Josep Rodés-Cabau, Susheel Kodali
BACKGROUND: The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. METHODS AND RESULTS: A total of 377 patients who underwent TAVR in 2 high-volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis...
February 20, 2017: Journal of the American Heart Association
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