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Rebecca Hahn

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https://www.readbyqxmd.com/read/29029153/modeling-the-environmental-suitability-for-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-diptera-culicidae-in-the-contiguous-united-states
#1
Tammi L Johnson, Ubydul Haque, Andrew J Monaghan, Lars Eisen, Micah B Hahn, Mary H Hayden, Harry M Savage, Janet McAllister, John-Paul Mutebi, Rebecca J Eisen
The mosquitoes Aedes (Stegomyia) aegypti (L.)(Diptera:Culicidae) and Ae. (Stegomyia) albopictus (Skuse) (Diptera:Culicidae) transmit dengue, chikungunya, and Zika viruses and represent a growing public health threat in parts of the United States where they are established. To complement existing mosquito presence records based on discontinuous, non-systematic surveillance efforts, we developed county-scale environmental suitability maps for both species using maximum entropy modeling to fit climatic variables to county presence records from 1960-2016 in the contiguous United States...
September 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29020232/staging-classification-of-aortic-stenosis-based-on-the-extent-of-cardiac-damage
#2
Philippe Généreux, Philippe Pibarot, Björn Redfors, Michael J Mack, Raj R Makkar, Wael A Jaber, Lars G Svensson, Samir Kapadia, E Murat Tuzcu, Vinod H Thourani, Vasilis Babaliaros, Howard C Herrmann, Wilson Y Szeto, David J Cohen, Brian R Lindman, Thomas McAndrew, Maria C Alu, Pamela S Douglas, Rebecca T Hahn, Susheel K Kodali, Craig R Smith, D Craig Miller, John G Webb, Martin B Leon
Aims: In patients with aortic stenosis (AS), risk stratification for aortic valve replacement (AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to evaluate the prognostic impact of a newly-defined staging classification characterizing the extent of extravalvular (extra-aortic valve) cardiac damage among patients with severe AS undergoing AVR. Methods and results: Patients with severe AS from the PARTNER 2 trials were pooled and classified according to the presence or absence of cardiac damage as detected by echocardiography prior to AVR: no extravalvular cardiac damage (Stage 0), left ventricular damage (Stage 1), left atrial or mitral valve damage (Stage 2), pulmonary vasculature or tricuspid valve damage (Stage 3), or right ventricular damage (Stage 4)...
July 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019612/unveiling-transthyretin-cardiac-amyloidosis-and-its-predictors-among-elderly-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#3
Adam Castaño, David L Narotsky, Nadira Hamid, Omar K Khalique, Rachelle Morgenstern, Albert DeLuca, Jonah Rubin, Codruta Chiuzan, Tamim Nazif, Torsten Vahl, Isaac George, Susheel Kodali, Martin B Leon, Rebecca Hahn, Sabahat Bokhari, Mathew S Maurer
Aims: Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients with severe symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) and determine the prevalence and phenotype of ATTR-CA non-invasively. Methods and results: We performed technetium-99m pyrophosphate (99mTc-PYP) cardiac scintigraphy prospectively on patients who underwent TAVR, to screen for ATTR-CA...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28982563/the-international-multicenter-trivalve%C3%A2-registry-which-patients-are-undergoing-transcatheter-tricuspid-repair
#4
Maurizio Taramasso, Rebecca T Hahn, Hannes Alessandrini, Azeem Latib, Adrian Attinger-Toller, Daniel Braun, Eric Brochet, Kim A Connelly, Paolo Denti, Florian Deuschl, Andrea Englmaier, Neil Fam, Christian Frerker, Joerg Hausleiter, Jean-Michel Juliard, Ryan Kaple, Felix Kreidel, Karl Heinz Kuck, Shingo Kuwata, Marco Ancona, Margarita Malasa, Tamim Nazif, Georg Nickenig, Fabian Nietlispach, Alberto Pozzoli, Ulrich Schäfer, Joachim Schofer, Robert Schueler, Gilbert Tang, Alec Vahanian, John G Webb, Ermela Yzeiraj, Francesco Maisano, Martin B Leon
OBJECTIVES: This study sought to develop a large, international registry to evaluate the diffusion of these approaches and investigate patient characteristics and initial clinical results. BACKGROUND: Several transcatheter tricuspid valve therapies are emerging as therapeutic options for patients with severe symptomatic tricuspid regurgitation (TR), generally a high-risk surgical population. METHODS: The TriValve (Transcatheter Tricuspid Valve Therapies) registry included 106 high-risk patients (76 ± 9 years of age; 60...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28977455/the-need-for-a-new-tricuspid-regurgitation-grading-scheme
#5
Rebecca T Hahn, Jose L Zamorano
No abstract text is available yet for this article.
July 13, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28973520/longitudinal-hemodynamics-of-transcatheter-and-surgical-aortic-valves-in-the-partner-trial
#6
Pamela S Douglas, Martin B Leon, Michael J Mack, Lars G Svensson, John G Webb, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, D Craig Miller, Samir Kapadia, Howard C Herrmann, Susheel K Kodali, Raj R Makkar, Vinod H Thourani, Stamatios Lerakis, Ashley M Lowry, Jeevanantham Rajeswaran, Matthew T Finn, Maria C Alu, Craig R Smith, Eugene H Blackstone
Importance: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective: To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Setting, and Participants: In this study, we analyzed core laboratory-generated data from echocardiograms of all patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1 Trial with successful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2, 3, 4, and 5 years postimplantation...
September 27, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28973091/association-of-paravalvular-regurgitation-with-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-valve
#7
Philippe Pibarot, Rebecca T Hahn, Neil J Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar K Khalique, Federico M Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Maria Alu, Howard Herrmann, Raj Makkar, Michael Mack, Richard Smalling, Martin Leon, Vinod H Thourani, Susheel Kodali
Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves. Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve. Design, Setting, and Participants: Prespecified analysis of PVR in the Placement of Aortic Transcatheter Valves (PARTNER) II SAPIEN 3 trial, conducted between October 1, 2013, and September 3, 2014...
September 27, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28874014/updated-reported-distribution-of-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-diptera-culicidae-in-the-united-states-1995-2016
#8
Micah B Hahn, Lars Eisen, Janet McAllister, Harry M Savage, John-Paul Mutebi, Rebecca J Eisen
Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) are potential vectors of Zika, dengue, and chikungunya viruses in the United States. A Zika virus outbreak in Florida in the summer of 2016, driven by Ae. aegypti and resulting in > 200 locally acquired cases of human illness, underscored the need for up-to-date information on the geographic distribution of Ae. aegypti and Ae. albopictus in the United States. In early 2016, we conducted a survey and literature review to compile county records for presence of Ae...
September 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28874013/response-the-geographic-distribution-of-ixodes-scapularis-acari-ixodidae-revisited-the-importance-of-assumptions-about-error-balance
#9
Micah B Hahn, Catherine S Jarnevich, Andrew J Monaghan, Rebecca J Eisen
No abstract text is available yet for this article.
September 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28751491/pediatric-chronic-critical-illness-reducing-excess-hospitalizations
#10
Renee D Boss, Erin P Williams, Carrie M Henderson, Rebecca R Seltzer, Miriam C Shapiro, Emily Hahn, Nancy Hutton
OBJECTIVES: The past 2 decades have seen an expanding pediatric population that is chronically critically ill: children with repeated and prolonged hospitalizations and ongoing dependence on technologies to sustain vital functions. Although illness complexity prompts many hospitalizations, our goal with this study was to explore modifiable patient, family, and health system contributions to excess hospital days for children with chronic critical illness (CCI). METHODS: Semistructured interviews were conducted with 51 stakeholders known for their CCI expertise...
July 27, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28734891/ct-defined-prosthesis-patient-mismatch-downgrades-frequency-and-severity-and%C3%A2-demonstrates-no-association-with-adverse-outcomes-after-tavr
#11
John Mooney, Stephanie L Sellers, Phillip Blanke, Philippe Pibarot, Rebecca T Hahn, Danny Dvir, Pamela S Douglas, Neil J Weissman, Susheel K Kodali, Vinod H Thourani, Hasan Jilaihawi, Omar Khalique, Craig R Smith, Shaw Hua Kueh, Mickael Ohana, Romi Grover, Christopher Naoum, Aaron Crowley, Wael A Jaber, Maria C Alu, Rupa Parvataneni, Michael Mack, John G Webb, Martin B Leon, Jonathon A Leipsic
OBJECTIVES: This study sought to determine if indexed effective orifice area (EOAi), using left ventricular outflow tract measured from computed tomography (EOAiCT), reclassified prosthesis-patient mismatch (PPM) compared with conventional echocardiogram-defined measurements (EOAiTTE). BACKGROUND: PPM does not predict mortality following transcatheter aortic valve replacement (TAVR). However, it is unknown if the EOAiCT of the left ventricular outflow tract improves risk stratification...
July 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28706866/current-transcatheter-devices-to-treat-functional-tricuspid-regurgitation-with-discussion-of-issues-relevant-to-clinical-trial-design
#12
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) has seen increased attention in recent times as relationships with clinically-relevant outcomes have come to light. Despite the association of increased mortality with significant TR, the disease remains under-recognized and thus relatively untreated. In addition, the disease itself has not been extensively studied and the interactions between annular dilatation, right heart disease and pulmonary hypertension are poorly understood. However, the high mortality and recurrence rate with current surgical replacement or repair techniques is well recognised, opening the door to transcatheter therapies for functional TR...
May 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28701528/blood-pressure-and-arterial-load-after-transcatheter-aortic-valve-replacement-for-aortic-stenosis
#13
MULTICENTER STUDY
Brian R Lindman, Catherine M Otto, Pamela S Douglas, Rebecca T Hahn, Sammy Elmariah, Neil J Weissman, William J Stewart, Girma M Ayele, Feifan Zhang, Alan Zajarias, Hersh S Maniar, Hasan Jilaihawi, Eugene Blackstone, Khaja M Chinnakondepalli, E Murat Tuzcu, Martin B Leon, Philippe Pibarot
BACKGROUND: After aortic valve replacement, left ventricular afterload is often characterized by the residual valve obstruction. Our objective was to determine whether higher systemic arterial afterload-as reflected in blood pressure, pulsatile and resistive load-is associated with adverse clinical outcomes after transcatheter aortic valve replacement (TAVR). METHODS AND RESULTS: Total, pulsatile, and resistive arterial load were measured in 2141 patients with severe aortic stenosis treated with TAVR in the PARTNER I trial (Placement of Aortic Transcatheter Valve) who had systolic blood pressure (SBP) and an echocardiogram obtained 30 days after TAVR...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28608869/an-ecoregion-based-approach-to-protecting-half-the-terrestrial-realm
#14
COMMENT
Eric Dinerstein, David Olson, Anup Joshi, Carly Vynne, Neil D Burgess, Eric Wikramanayake, Nathan Hahn, Suzanne Palminteri, Prashant Hedao, Reed Noss, Matt Hansen, Harvey Locke, Erle C Ellis, Benjamin Jones, Charles Victor Barber, Randy Hayes, Cyril Kormos, Vance Martin, Eileen Crist, Wes Sechrest, Lori Price, Jonathan E M Baillie, Don Weeden, Kierán Suckling, Crystal Davis, Nigel Sizer, Rebecca Moore, David Thau, Tanya Birch, Peter Potapov, Svetlana Turubanova, Alexandra Tyukavina, Nadia de Souza, Lilian Pintea, José C Brito, Othman A Llewellyn, Anthony G Miller, Annette Patzelt, Shahina A Ghazanfar, Jonathan Timberlake, Heinz Klöser, Yara Shennan-Farpón, Roeland Kindt, Jens-Peter Barnekow Lillesø, Paulo van Breugel, Lars Graudal, Maianna Voge, Khalaf F Al-Shammari, Muhammad Saleem
We assess progress toward the protection of 50% of the terrestrial biosphere to address the species-extinction crisis and conserve a global ecological heritage for future generations. Using a map of Earth's 846 terrestrial ecoregions, we show that 98 ecoregions (12%) exceed Half Protected; 313 ecoregions (37%) fall short of Half Protected but have sufficient unaltered habitat remaining to reach the target; and 207 ecoregions (24%) are in peril, where an average of only 4% of natural habitat remains. We propose a Global Deal for Nature-a companion to the Paris Climate Deal-to promote increased habitat protection and restoration, national- and ecoregion-scale conservation strategies, and the empowerment of indigenous peoples to protect their sovereign lands...
June 1, 2017: Bioscience
https://www.readbyqxmd.com/read/28557480/patient-reported-outcome-measures-in-huntington-disease-quality-of-life-in-neurological-disorders-neuro-qol-social-functioning-measures
#15
Noelle E Carlozzi, Elizabeth A Hahn, Siera M Goodnight, Anna L Kratz, Jane S Paulsen, Julie C Stout, Samuel Frank, Jennifer A Miner, David Cella, Richard C Gershon, Stephen G Schilling, Rebecca E Ready
Social functioning is an essential but poorly understood component of health-related quality of life (HRQOL) for people with Huntington disease (HD). We report on the psychometric properties of 2 Neuro-QoL patient-reported outcome measures to assess social functioning in HD. Persons with prodromal (n = 198) or manifest HD (n = 195 early and n = 117 late) completed Neuro-QoL Ability to Participate in Social Roles and Activities, and Satisfaction with Social Roles and Activities. Items from 2 generic HRQOL patient-reported outcome measures were used to create a social functioning composite score; items from the Unified Huntington's Disease Rating Scale and Problem Behaviors Assessment Scale were used to create a clinician-rated composite score of social function...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28556412/patient-reported-outcomes-in-huntington-s-disease-quality-of-life-in-neurological-disorders-neuro-qol-and-huntington-s-disease-health-related-quality-of-life-hdqlife-physical-function-measures
#16
Noelle E Carlozzi, Rebecca E Ready, Samuel Frank, David Cella, Elizabeth A Hahn, Siera M Goodnight, Stephen G Schilling, Nicholas R Boileau, Praveen Dayalu
BACKGROUND: There is a need for patient-reported outcome measures that capture the impact that motor impairments have on health-related quality of life in individuals with Huntington's disease. OBJECTIVES: The objectives of this study were to establish the reliability and validity of new physical functioning patient-reported outcome measures in Huntington's disease. METHODS: A total of 510 individuals with Huntington's disease completed 2 Quality of Life in Neurological Disorders (Lower Extremity Function and Upper Extremity Function) and 3 Huntington's Disease Health-Related Quality of Life (Chorea, Speech Difficulties, and Swallowing Difficulties) measures...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28494976/prognostic-implications-of-moderate-aortic%C3%A2-stenosis-in-patients-with-left%C3%A2-ventricular-systolic%C3%A2-dysfunction
#17
MULTICENTER STUDY
Lennart van Gils, Marie-Annick Clavel, E Mara Vollema, Rebecca T Hahn, Ernest Spitzer, Victoria Delgado, Tamim Nazif, Peter P De Jaegere, Marcel L Geleijnse, Ori Ben-Yehuda, Jeroen J Bax, Martin B Leon, Philippe Pibarot, Nicolas M Van Mieghem
BACKGROUND: Left ventricular (LV) systolic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexist. Afterload reduction is the mainstay of pharmacological treatment of heart failure (HF). Aortic valve replacement (AVR) is only formally indicated for symptomatic severe AS. OBJECTIVES: This study sought to determine the clinical outcome of patients with concomitant moderate AS and LV systolic dysfunction. METHODS: Echocardiographic and clinical data of patients with moderate AS and LV systolic dysfunction between 2010 and 2015 from 4 large academic institutions were retrospectively analyzed...
May 16, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28487320/aortic-valve-annular-sizing-intraoperative-assessment-versus-preoperative-multidetector-computed-tomography
#18
COMPARATIVE STUDY
Isaac George, Laura C Guglielmetti, Nicolas Bettinger, Andrew Moss, Catherine Wang, Nathan Kheysin, Rebecca Hahn, Susheel Kodali, Martin Leon, Vinayak Bapat, Michael A Borger, Mathew Williams, Craig Smith, Omar K Khalique
BACKGROUND: Appropriate valve sizing is critical in aortic valve replacement. We hypothesized that direct intraoperative valve sizing results in smaller aortic annular diameters compared with sizing based on systolic-phase multidetector computerized tomographic (MDCT) imaging. METHODS AND RESULTS: We retrospectively analyzed 78 patients undergoing surgical aortic valve replacement for severe aortic stenosis between 2012 and 2014 at our institution. Preoperative MDCT measurements of the aortic annulus served as basis for assignment to a theoretical surgical valve size, which was then (1) compared to the implanted valve size and (2) to a theoretical transcatheter aortic valve replacement valve size...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28470996/impact-of-small-prosthesis-size-on-transcatheter-or-surgical-aortic-valve-replacement-outcomes
#19
Michael Salna, Omar K Khalique, Codruta Chiuzan, Paul Kurlansky, Michael A Borger, Rebecca T Hahn, Martin B Leon, Craig R Smith, Susheel K Kodali, Isaac George
OBJECTIVES: Determine the comparative impact of small prosthesis size on transcatheter and surgical aortic valve replacement (SAVR) outcomes. BACKGROUND: Patients with small aortic annuli tend to have worse postoperative outcomes and hemodynamics. We sought to describe surgical outcomes in patients with very small aortic annuli and then compare early hemodynamic and clinical outcomes in patients undergoing surgical or transcatheter aortic valve replacement (TAVR) with the smallest available valves to assist in optimal prosthesis selection for this challenging patient population...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28457950/practical-determination-of-aortic-valve-calcium-volume-score-on-contrast-enhanced-computed-tomography-prior-to-transcatheter-aortic-valve-replacement-and-impact-on-paravalvular-regurgitation-elucidating-optimal-threshold-cutoffs
#20
Nicolas Bettinger, Omar K Khalique, Joseph M Krepp, Nadira B Hamid, David J Bae, Todd C Pulerwitz, Ming Liao, Rebecca T Hahn, Torsten P Vahl, Tamim M Nazif, Isaac George, Martin B Leon, Andrew J Einstein, Susheel K Kodali
BACKGROUND: The threshold for the optimal computed tomography (CT) number in Hounsfield Units (HU) to quantify aortic valvular calcium on contrast-enhanced scans has not been standardized. Our aim was to find the most accurate threshold to predict paravalvular regurgitation (PVR) after transcatheter aortic valve replacement (TAVR). METHODS: 104 patients who underwent TAVR with the CoreValve prosthesis were studied retrospectively. Luminal attenuation (LA) in HU was measured at the level of the aortic annulus...
July 2017: Journal of Cardiovascular Computed Tomography
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