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Rebecca Hahn

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https://www.readbyqxmd.com/read/28177281/copy-number-and-gene-dependency-analysis-reveals-partial-copy-loss-of-wild-type-sf3b1-as-a-novel-cancer-vulnerability
#1
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number associated gene dependencies). The most enriched class of copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS) genes, and spliceosome components were the most prevalent...
February 8, 2017: ELife
https://www.readbyqxmd.com/read/28039322/injuries-to-the-aorta-aortic-annulus-and-left-ventricle-during-transcatheter-aortic-valve-replacement-management-and-outcomes
#2
Nathaniel B Langer, Nadira B Hamid, Tamim M Nazif, Omar K Khalique, Torsten P Vahl, Jonathon White, Juan Terre, Ramin Hastings, Diana Leung, Rebecca T Hahn, Martin Leon, Susheel Kodali, Isaac George
The experience with transcatheter aortic valve replacement is increasing worldwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not decreased. In most cases, significant injuries to the aorta, aortic valve annulus, and left ventricle require open surgical repair. However, the transcatheter aortic valve replacement patient presents a unique challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgical procedure may not be feasible or appropriate...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28017714/long-term-valve-performance-of-tavr-and-savr-a-report-from-the-partner-i-trial
#3
Melissa A Daubert, Neil J Weissman, Rebecca T Hahn, Philippe Pibarot, Rupa Parvataneni, Michael J Mack, Lars G Svensson, Deepika Gopal, Samir Kapadia, Robert J Siegel, Susheel K Kodali, Wilson Y Szeto, Raj Makkar, Martin B Leon, Pamela S Douglas
OBJECTIVES: The aim of this study was to evaluate the long-term performance of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) through longitudinal echocardiographic analysis. BACKGROUND: The long-term performance of the SAPIEN TAVR is not well-described. Therefore, we examined the hemodynamic and valvular profile of the SAPIEN TAVR over 5 years. METHODS: All patients receiving TAVR or SAVR with first post-implant (FPI) and 5-year echoes were analyzed for aortic valve (AV) peak velocity, AV mean gradient, AV area, peak left ventricular (LV) outflow tract and in-stent velocities, Doppler velocity index, aortic regurgitation (AR), LV mass index, stroke volume index, and cardiac index...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27986555/serological-approaches-for-the-diagnosis-of-schistosomiasis-a-review
#4
Rebecca Hinz, Norbert G Schwarz, Andreas Hahn, Hagen Frickmann
Schistosomiasis is a common disease in endemic areas of Sub-Saharan Africa, South America and Asia. It is rare in Europe, mainly imported from endemic countries due to travelling or human migration. Available methods for the diagnosis of schistosomiasis comprise microscopic, molecular and serological approaches, with the latter detecting antigens or antibodies associated with Schistosoma spp. infection. The serological approach is a valuable screening tool in low-endemicity settings and for travel medicine, though the interpretation of any diagnostic results requires knowledge of test characteristics and a patient's history...
December 13, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27974407/state-of-the-art-review-of-echocardiographic-imaging-in-the-evaluation-and-treatment-of-functional-tricuspid-regurgitation
#5
Rebecca T Hahn
Functional or secondary tricuspid regurgitation (TR) is the most common cause of severe TR in the Western world. The presence of functional TR, either isolated or in combination with left heart disease, is associated with unfavorable natural history. Surgical mortality for isolated tricuspid valve interventions remains higher than for any other single valve surgery, and surgical options for repair do not have consistent long-term durability. In addition, as more patients undergo transcatheter left valve interventions, developing transcatheter solutions for functional TR has gained greater momentum...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27970251/tct-86-early-experience-with-the-trialign-system-for-transcatheter-tricuspid-valve-repair-a-multicenter-experience
#6
Ermela Yzeiraj, Horst Sievert, Georg Nickenig, Azeem Latib, Rebecca Hahn, Joachim Schofer
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970209/tct-819-clinical-outcome-in-patients-with-heart-failure-and-moderate-aortic-stenosis
#7
Lennart van Gils, Marie-Annick Clavel, Mara Vollema, Victoria Delgado, Tamim Nazif, Ernest Spitzer, Rebecca Hahn, Jeroen Bax, Martin Leon, Philippe Pibarot, Nicolas Van Mieghem
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970151/tct-77-association-of-residual-mitral-regurgitation-after-transcatheter-aortic-valve-replacement-with-readmission-for-acute-heart-failure-an-analysis-from-partner-1
#8
John Petersen, Eugene Blackstone, Jeevanantham Rajeswaran, David Cohen, Pamela Douglas, Rebecca Hahn, Susheel Kodali, Lars Svensson, Martin Leon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970078/tct-699-anatomic-deployment-index-a-novel-measure-of-sapien-3-transcatheter%C3%A2-heart-valve-performance
#9
Rebecca Hahn, Maria Alu, Jonathon Leipsic, Pamela Douglas, Wael Jaber, Neil Weissman, Omar Khalique, Philipp Blanke, Rupa Parvataneni, Susheel Kodali, Vinod Thourani, Philippe Pibarot
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970068/tct-691-sex-specific-differences-after-transcatheter-or-surgical-aortic-valve-replacement-in-intermediate-risk-patients-an-analysis-from-the-partner-2-randomized-trial
#10
Jonathan White, Darshan Doshi, Mathew Williams, Molly Szerlip, John Squiers, John Webb, Rebecca Hahn, Ajay Kirtane, Claire Litherland, David Cohen, E Murat Tuzcu, Wilson Szeto, Alan Zajarias, S Chris Malaisrie, Maria Alu, Craig Smith, Martin Leon, Michael Mack, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970058/tct-679-diabetes-and-clinical-outcomes-in-intermediate-risk-patients-randomized-to-transcatheter-versus-surgical-aortic-valve-replacement-an-analysis-of-the-partner-2a-trial
#11
Brian Lindman, Yigal Abramowitz, Philippe Pibarot, Nishath Quader, Hersh Maniar, Alan Zajarias, Suzanne Arnold, Rebecca Hahn, Sammy Elmariah, Rakesh Suri, Torsten Vahl, Lars Svensson, Vinod Thourani, Claire Litherland, Maria Alu, Martin Leon, Raj Makkar
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970050/tct-674-sex-specific-outcomes-of-tavr-with-the-sapien-3-valve-insights-from-the-partner-2-s3-high-risk-and-intermediate-risk-cohorts
#12
Molly Szerlip, Sarah Gualano, John Squiers, Jonathon White, Darshan Doshi, Isaac George, Nicolas Vazquez, John Michael Dimaio, Raj Makkar, Mathew Williams, Howard Herrmann, Lars Svensson, John Webb, Rebecca Hahn, Ajay Kirtane, Vasilis Babaliaros, Vinod Thourani, Maria Alu, Susheel Kodali, Martin Leon, Michael Mack
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970039/tct-665-association-of-paravalvular-leak-after-transcatheter-aortic-valve-replacement-with-readmission-for-acute-heart-failure-an-analysis-from%C3%A2-partner-1
#13
John Petersen, Eugene Blackstone, Jeevanantham Rajeswaran, David Cohen, Pamela Douglas, Rebecca Hahn, Susheel Kodali, Lars Svensson, Martin Leon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970030/tct-654-risk-of-readmission-for-acute-heart-failure-subsequent-readmission-and-mortality-following-transcatheter-aortic-valve-replacement-an-analysis-from-partner-1
#14
John Petersen, Eugene Blackstone, Jeevanantham Rajeswaran, David Cohen, Pamela Douglas, Rebecca Hahn, Susheel Kodali, Lars Svensson, Martin Leon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969743/tct-38-paravalvular-regurgitation-regression-and-impact-on-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-transcatheter-valve
#15
Philippe Pibarot, Rebecca Hahn, Neil Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar Khalique, Federico Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Howard Herrmann, Martin Leon, Vinod Thourani, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27939049/impact-of-methodologic-differences-in-three-dimensional-echocardiographic-measurements-of-the-aortic-annulus-compared-with-computed-tomographic-angiography-before-transcatheter-aortic-valve-replacement
#16
Omar K Khalique, Nadira B Hamid, Jonathon M White, David J Bae, Susheel K Kodali, Tamim M Nazif, Torsten P Vahl, Jean-Michel Paradis, Isaac George, Martin B Leon, Rebecca T Hahn
BACKGROUND: Three-dimensional (3D) echocardiographic (3DE) imaging is an alternative to multi-detector row computed tomography (MDCT) for aortic annular measurement before transcatheter aortic valve replacement (TAVR). A commonly used direct planimetry from a reconstructed short-axis view has not been compared with semiautomated 3DE methods. Typically accepted optimal cutoffs for percent prosthesis-area oversizing of the balloon-expandable SAPIEN or SAPIEN XT valve to native annular size are approximately 5% to 15%...
December 6, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27914503/rationale-and-design-of-the-transcatheter-aortic-valve-replacement-to-unload-the-left-ventricle-in-patients-with-advanced-heart-failure-tavr-unload-trial
#17
Ernest Spitzer, Nicolas M Van Mieghem, Philippe Pibarot, Rebecca T Hahn, Susheel Kodali, Mathew S Maurer, Tamim M Nazif, Josep Rodés-Cabau, Jean-Michel Paradis, Arie-Pieter Kappetein, Ori Ben-Yehuda, Gerrit-Anne van Es, Faouzi Kallel, William N Anderson, Jan Tijssen, Martin B Leon
BACKGROUND: Coexistence of moderate aortic stenosis (AS) in patients with heart failure (HF) with reduced ejection fraction is not uncommon. Moderate AS increases afterload, whereas pharmacologic reduction of afterload is a pillar of contemporary HF management. HYPOTHESIS: Unloading the left ventricle by reducing the transaortic gradient with transfemoral transcatheter aortic valve replacement (TAVR) may improve clinical outcomes in patients with moderate AS and HF with reduced ejection fraction...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27727246/data-from-a-pre-publication-independent-replication-initiative-examining-ten-moral-judgement-effects
#18
MULTICENTER STUDY
Warren Tierney, Martin Schweinsberg, Jennifer Jordan, Deanna M Kennedy, Israr Qureshi, S Amy Sommer, Nico Thornley, Nikhil Madan, Michelangelo Vianello, Eli Awtrey, Luke Lei Zhu, Daniel Diermeier, Justin E Heinze, Malavika Srinivasan, David Tannenbaum, Eliza Bivolaru, Jason Dana, Clintin P Davis-Stober, Christilene du Plessis, Quentin F Gronau, Andrew C Hafenbrack, Eko Yi Liao, Alexander Ly, Maarten Marsman, Toshio Murase, Michael Schaerer, Christina M Tworek, Eric-Jan Wagenmakers, Lynn Wong, Tabitha Anderson, Christopher W Bauman, Wendy L Bedwell, Victoria Brescoll, Andrew Canavan, Jesse J Chandler, Erik Cheries, Sapna Cheryan, Felix Cheung, Andrei Cimpian, Mark A Clark, Diana Cordon, Fiery Cushman, Peter H Ditto, Alice Amell, Sarah E Frick, Monica Gamez-Djokic, Rebecca Hofstein Grady, Jesse Graham, Jun Gu, Adam Hahn, Brittany E Hanson, Nicole J Hartwich, Kristie Hein, Yoel Inbar, Lily Jiang, Tehlyr Kellogg, Nicole Legate, Timo P Luoma, Heidi Maibeucher, Peter Meindl, Jennifer Miles, Alexandra Mislin, Daniel C Molden, Matt Motyl, George Newman, Hoai Huong Ngo, Harvey Packham, P Scott Ramsay, Jennifer L Ray, Aaron M Sackett, Anne-Laure Sellier, Tatiana Sokolova, Walter Sowden, Daniel Storage, Xiaomin Sun, Jay J Van Bavel, Anthony N Washburn, Cong Wei, Erik Wetter, Carlos T Wilson, Sophie-Charlotte Darroux, Eric Luis Uhlmann
We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27671968/sexual-satisfaction-and-the-importance-of-sexual-health-to-quality-of-life-throughout-the-life-course-of-u-s-adults
#19
Kathryn E Flynn, Li Lin, Deborah Watkins Bruner, Jill M Cyranowski, Elizabeth A Hahn, Diana D Jeffery, Jennifer Barsky Reese, Bryce B Reeve, Rebecca A Shelby, Kevin P Weinfurt
INTRODUCTION: Discussions about sexual health are uncommon in clinical encounters, despite the sexual dysfunction associated with many common health conditions. Understanding of the importance of sexual health and sexual satisfaction in U.S. adults is limited. AIM: To provide epidemiologic data on the importance of sexual health for quality of life and people's satisfaction with their sex lives and to examine how each is associated with demographic and health factors...
November 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27663933/palliative-radiation-therapy-for-bone-metastases-update-of-an-astro-evidence-based-guideline
#20
Stephen Lutz, Tracy Balboni, Joshua Jones, Simon Lo, Joshua Petit, Shayna E Rich, Rebecca Wong, Carol Hahn
PURPOSE: The purpose is to provide an update the Bone Metastases Guideline published in 2011 based on evidence complemented by expert opinion. The update will discuss new high-quality literature for the 8 key questions from the original guideline and implications for practice. METHODS AND MATERIALS: A systematic PubMed search from the last date included in the original Guideline yielded 414 relevant articles. Ultimately, 20 randomized controlled trials, 32 prospective nonrandomized studies, and 4 meta-analyses/pooled analyses were selected and abstracted into evidence tables...
January 2017: Practical Radiation Oncology
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