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Rebecca Hahn

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https://www.readbyqxmd.com/read/29403655/influence-of-broth-enrichment-as-well-as-storage-and-transport-time-on-the-sensitivity-of-mrsa-surveillance-in-the-tropics
#1
Hagen Frickmann, Andreas Hahn, Norbert Georg Schwarz, Ralf Matthias Hagen, Denise Dekker, Rebecca Hinz, Volker Micheel, Benedikt Hogan, Jürgen May, Raphael Rakotozandrindrainy
Direct growth on blood and screening agar for methicillin-resistant Staphylococcus aureus (MRSA) at a tropical surveillance site was compared with broth enrichment and subsequent growth on selective MRSA agar after international sample transport. In Madagascar, 1548 swabs from an MRSA surveillance study were assessed for growth on Columbia blood agar enriched with 5% sheep blood and MRSA screening agar at the surveillance site with subsequent cold storage of the samples and shipment to Germany. In Germany, 1541 shipped samples were analyzed by non-selective broth enrichment with subsequent culture on MRSA selective agar...
December 18, 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29397928/transcatheter-aortic-valve-replacement-by-a-novel-suprasternal-approach
#2
Pablo Codner, Daniel Pugliese, Rémi Kouz, Amisha Patel, Cheng-Han Chen, Juan Terre, Kyle M Eudaley, Tamim Nazif, Torsten P Vahl, Isaac George, Omar K Khalique, Rebecca T Hahn, Martin B Leon, Susheel Kodali, Michael Borger
BACKGROUND: Transcatheter aortic valve replacement (TAVR) provides therapy for patients with severe aortic stenosis at extreme, high, or intermediate surgical risk. Transfemoral access has been the preferred access route; however, this approach is not suitable for many TAVR candidates. A suprasternal approach may allow for earlier ambulation and shorter hospital stay as compared with other, nontransfemoral approaches. METHODS: A total of 11 patients with unsuitable transfemoral access underwent suprasternal TAVR...
February 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29358344/standardized-definition-of-structural-valve-degeneration-for-surgical-and-transcatheter-bioprosthetic-aortic-valves
#3
REVIEW
Danny Dvir, Thierry Bourguignon, Catherine M Otto, Rebecca T Hahn, Raphael Rosenhek, John G Webb, Hendrik Treede, Maurice E Sarano, Ted Feldman, Harindra C Wijeysundera, Yan Topilsky, Michel Aupart, Michael J Reardon, G Burkhard Mackensen, Wilson Y Szeto, Ran Kornowski, James S Gammie, Ajit P Yoganathan, Yaron Arbel, Michael A Borger, Matheus Simonato, Mark Reisman, Raj R Makkar, Alexandre Abizaid, James M McCabe, Gry Dahle, Gabriel S Aldea, Jonathon Leipsic, Philippe Pibarot, Neil E Moat, Michael J Mack, A Pieter Kappetein, Martin B Leon
Bioprostheses are prone to structural valve degeneration, resulting in limited long-term durability. A significant challenge when comparing the durability of different types of bioprostheses is the lack of a standardized terminology for the definition of a degenerated valve. This issue becomes especially important when we try to compare the degeneration rate of surgically inserted and transcatheter bioprosthetic valves. This document, by the VIVID (Valve-in-Valve International Data), proposes practical and standardized definitions of valve degeneration and provides recommendations for the timing of clinical and imaging follow-up assessments accordingly...
January 23, 2018: Circulation
https://www.readbyqxmd.com/read/29301644/sex-specific-outcomes-of-transcatheter%C3%A2-aortic-valve-replacement-with-the-sapien-3-valve-insights-from-the-partner-ii-s3-high-risk-and-intermediate-risk-cohorts
#4
Molly Szerlip, Sarah Gualano, Elizabeth Holper, John J Squiers, Jonathon M White, Darshan Doshi, Mathew R Williams, Rebecca T Hahn, John G Webb, Lars G Svensson, Ajay J Kirtane, David J Cohen, Pamela S Douglas, Maria C Alu, Aaron Crowley, E Murat Tuzcu, Raj R Makkar, Howard C Herrmann, Vasilis Babaliaros, Vinod H Thourani, Martin B Leon, Susheel K Kodali, Michael J Mack
OBJECTIVES: The purpose of this study was to identify sex-specific outcomes of intermediate risk patients undergoing transcatheter aortic valve replacement with the SAPIEN 3 valve. BACKGROUND: A survival difference has been observed in women as compared with men in inoperable and high-risk patients receiving early-generation balloon-expandable valves for transcatheter aortic valve replacement (TAVR). Whether a sex-specific outcome difference persists with newer-generation valves and in lower-risk patients is unknown...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29275985/echocardiographic-imaging-for-transcatheter-aortic-valve-replacement
#5
REVIEW
Rebecca T Hahn, Alina Nicoara, Samir Kapadia, Lars Svensson, Randolph Martin
Transcatheter aortic valve replacement has become an accepted alternative to surgery for patients with severe, symptomatic aortic stenosis who are inoperable or are at high surgical risk. Recent trials support the use of transcatheter aortic valve replacement also in patients at intermediate risk, and ongoing trials are assessing appropriateness in other patient groups. The authors review the key anatomic features integral to the transcatheter aortic valve replacement procedure and the echocardiographic imaging required for preprocedural, intraprocedural, and postprocedural assessment...
December 21, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29260723/compare-and-contrast-tricuspid-and-mitral-valve-anatomy-interventional-perspectives-for-transcatheter-tricuspid-valve-therapies
#6
Maurizio Taramasso, Alberto Pozzoli, Cristina Basso, Gaetano Thiene, Paolo Denti, Shingo Kuwata, Fabian Nietlispach, Ottavio Alfieri, Rebecca T Hahn, Georg Nickenig, Joachim Schofer, Martin B Leon, Mark Reisman, Francesco Maisano
Moving treanscatheter valve intervention towards atrioventricular (AV) valves implies increasing complexity. Part of the knowledge that has been generated during the development of mitral devices can be transferred to the tricuspid valve (TV). A deep understanding of the peculiar anatomy of the TV and of the right heart chambers, with differences and similarities between the two AV valves is fundamental to overcome the specific challenges related to transcatheter TV therapies. The aim of this report is to explore similarities and differences between mitral and tricuspid apparatus, and their interventional implications...
December 19, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29217004/transapical-transcatheter-aortic-valve-replacement-is-associated-with-increased-cardiac-mortality-in-patients-with-left%C3%A2-ventricular-dysfunction-insights-from-the-partner-i-trial
#7
Sammy Elmariah, William F Fearon, Ignacio Inglessis, Gus J Vlahakes, Brian R Lindman, Maria C Alu, Aaron Crowley, Susheel Kodali, Martin B Leon, Lars Svensson, Philippe Pibarot, Rebecca T Hahn, Vinod H Thourani, Igor F Palacios, D Craig Miller, Pamela S Douglas, Jonathan J Passeri
OBJECTIVES: The authors sought to evaluate the impact of transapical (TA) transcatheter aortic valve replacement (TAVR) on mortality, left ventricular (LV) ejection fraction (LVEF) improvement, and functional recovery in patients with LV dysfunction. BACKGROUND: LV injury inherent to TA access for structural heart disease interventions may be particularly detrimental to the LV, functional recovery, and survival in patients with LV dysfunction. METHODS: The study included patients enrolled within the PARTNER I (Placement of Aortic Transcatheter Valves) trial that underwent transfemoral (TF) or TA TAVR...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29195857/evaluating-acarological-risk-for-exposure-to-ixodes-scapularis-and-ixodes-scapularis-borne-pathogens-in-recreational-and-residential-settings-in-washington-county-minnesota
#8
Micah B Hahn, Jenna K H Bjork, David F Neitzel, Frances M Dorr, Tessa Whitemarsh, Karen A Boegler, Christine B Graham, Tammi L Johnson, Sarah E Maes, Rebecca J Eisen
The distribution of I. scapularis, the tick vector of the bacteria that cause Lyme disease, has been expanding over the last two decades in the north-central United States in parallel with increasing incidence of human cases of Lyme disease in that region. However, assessments of residential risk for exposure to ticks are lacking from this region. Here, we measured the density of host-seeking I. scapularis nymphs in two suburban and two rural public recreational sites located in Washington County, Minnesota as well as in nearby residential properties...
November 22, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29157520/interventional-imaging-of-the-tricuspid-valve
#9
REVIEW
Francesco Ancona, Eustachio Agricola, Stefano Stella, Cristina Capogrosso, Claudia Marini, Alberto Margonato, Rebecca T Hahn
Nowadays, reasonable transcatheter tricuspid valve (TV) interventions are emerging as therapeutic options for functional tricuspid regurgitation (TR). The preprocedural planning is based on a multimodality imaging approach, which aims to (1) define the mechanisms of TR, (2) characterize TV morphology, (3) analyze the anatomic relationship between the TV apparatus and other structures, and (4) determine the size of the tricuspid annulus and vena cavae. Intraprocedural guidance is based mainly on transesophageal echocardiography (seldom transthoracic) and fluoroscopy, with the recent introduction of fusion imaging...
January 2018: Interventional cardiology clinics
https://www.readbyqxmd.com/read/29113809/mir21-drives-resistance-to-heat-shock-protein-90-inhibition-in-cholangiocarcinoma
#10
Andrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis, Luciano Cascione, Somaieh Hedayat, Rosemary Burke, Paul Clarke, Else Bosma, Michele Simbolo, Aldo Scarpa, Sijia Yu, Rebecca Cole, Elizabeth Smyth, Javier Fernández Mateos, Ruwaida Begum, Blanka Hezelova, Zakaria Eltahir, Andrew Wotherspoon, Nicos Fotiadis, Maria Antonietta Bali, Chirag Nepal, Khurum Khan, Mark Stubbs, Jens C Hahne, Pierluigi Gasparini, Vincenza Guzzardo, Carlo M Croce, Suzanne Eccles, Matteo Fassan, David Cunningham, Jesper B Andersen, Paul Workman, Nicola Valeri, Chiara Braconi
BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA21 mediates resistance of CCA cells and organoids to HSP90 inhibitors. METHODS: We performed a high-throughput screen of 484 small molecule compounds to identify those that reduced viability of 6 human CCA cell lines...
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29098284/association-of-alterations-in-main-driver-genes-with-outcomes-of-patients-with-resected-pancreatic-ductal-adenocarcinoma
#11
Zhi Rong Qian, Douglas A Rubinson, Jonathan A Nowak, Vicente Morales-Oyarvide, Richard F Dunne, Margaret M Kozak, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L Zellers, Chen Yuan, Ana Babic, Natalia Khalaf, Andrew Aguirre, Kimmie Ng, Rebecca A Miksad, Andrea J Bullock, Daniel T Chang, Jennifer F Tseng, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew Ducar, Bruce Wollison, Angelica Laing, William C Hahn, Matthew Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Brian M Wolpin
Importance: Although patients with resected pancreatic adenocarcinoma are at high risk for disease recurrence, few biomarkers are available to inform patient outcomes. Objective: To evaluate the alterations of the 4 main driver genes in pancreatic adenocarcinoma and patient outcomes after cancer resection. Design, Setting, and Participants: This study analyzed protein expression and DNA alterations for the KRAS, CDKN2A, SMAD4, and TP53 genes by immunohistochemistry and next-generation sequencing in formalin-fixed, paraffin-embedded tumors in 356 patients with resected pancreatic adenocarcinoma who were treated at the Dana-Farber/Brigham and Women's Cancer Center (October 26, 2002, to May 21, 2012), University of Rochester Medical Center (March 1, 2006, to November 1, 2013), or Stanford Cancer Institute (September 26, 1995, to May 22, 2013)...
November 2, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29083316/electromechanical-wave-imaging-and-electromechanical-wave-velocity-estimation-in-a-large-animal-model-of-myocardial-infarction
#12
Alexandre Costet, Lea Melki, Vincent Sayseng, Nadira Hamid, Koki Nakanishi, Elaine Wan, Rebecca Hahn, Shunichi Homma, Elisa E Konofagou
Echocardiography is often used in the clinic for detection and characterization of myocardial infarction. Electromechanical wave imaging (EWI) is a novel, non-invasive ultrasound based imaging technique based on time domain incremental motion and strain estimation that can evaluate changes in contractility in the heart. In this study, electromechanical activation is assessed in infarcted heart to determine whether EWI is capable of detecting and monitoring infarct formation. Additionally, methods for estimating electromechanical wave (EW) velocity are presented, and changes in the EW propagation velocity after infarct formation are studied...
October 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29075913/role-of-echocardiography-in-transcatheter-valvular-heart-disease-interventions
#13
REVIEW
Omar K Khalique, Rebecca T Hahn
PURPOSE OF REVIEW: Transcatheter valvular interventions have increased in importance and utility for surgical valve repair and replacement. Cardiac imaging is the most crucial aspect of procedural planning and guidance. Echocardiography is a widely used, portable, and dynamic imaging modality used for many of these interventions. This review will summarize the role echocardiography in structural heart valvular interventions. RECENT FINDINGS: Intraprocedural echocardiographic guidance has been a mainstay of structural heart interventions...
October 27, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/29029153/modeling-the-environmental-suitability-for-aedes-stegomyia-aegypti-and-aedes-stegomyia-albopictus-diptera-culicidae-in-the-contiguous-united-states
#14
Tammi L Johnson, Ubydul Haque, Andrew J Monaghan, Lars Eisen, Micah B Hahn, Mary H Hayden, Harry M Savage, Janet McAllister, John-Paul Mutebi, Rebecca J Eisen
The mosquitoes Aedes (Stegomyia) aegypti (L.)(Diptera:Culicidae) and Ae. (Stegomyia) albopictus (Skuse) (Diptera:Culicidae) transmit dengue, chikungunya, and Zika viruses and represent a growing public health threat in parts of the United States where they are established. To complement existing mosquito presence records based on discontinuous, non-systematic surveillance efforts, we developed county-scale environmental suitability maps for both species using maximum entropy modeling to fit climatic variables to county presence records from 1960-2016 in the contiguous United States...
November 7, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29020232/staging-classification-of-aortic-stenosis-based-on-the-extent-of-cardiac-damage
#15
Philippe Généreux, Philippe Pibarot, Björn Redfors, Michael J Mack, Raj R Makkar, Wael A Jaber, Lars G Svensson, Samir Kapadia, E Murat Tuzcu, Vinod H Thourani, Vasilis Babaliaros, Howard C Herrmann, Wilson Y Szeto, David J Cohen, Brian R Lindman, Thomas McAndrew, Maria C Alu, Pamela S Douglas, Rebecca T Hahn, Susheel K Kodali, Craig R Smith, D Craig Miller, John G Webb, Martin B Leon
Aims: In patients with aortic stenosis (AS), risk stratification for aortic valve replacement (AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to evaluate the prognostic impact of a newly-defined staging classification characterizing the extent of extravalvular (extra-aortic valve) cardiac damage among patients with severe AS undergoing AVR. Methods and results: Patients with severe AS from the PARTNER 2 trials were pooled and classified according to the presence or absence of cardiac damage as detected by echocardiography prior to AVR: no extravalvular cardiac damage (Stage 0), left ventricular damage (Stage 1), left atrial or mitral valve damage (Stage 2), pulmonary vasculature or tricuspid valve damage (Stage 3), or right ventricular damage (Stage 4)...
July 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019612/unveiling-transthyretin-cardiac-amyloidosis-and-its-predictors-among-elderly-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#16
Adam Castaño, David L Narotsky, Nadira Hamid, Omar K Khalique, Rachelle Morgenstern, Albert DeLuca, Jonah Rubin, Codruta Chiuzan, Tamim Nazif, Torsten Vahl, Isaac George, Susheel Kodali, Martin B Leon, Rebecca Hahn, Sabahat Bokhari, Mathew S Maurer
Aims: Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients with severe symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) and determine the prevalence and phenotype of ATTR-CA non-invasively. Methods and results: We performed technetium-99m pyrophosphate (99mTc-PYP) cardiac scintigraphy prospectively on patients who underwent TAVR, to screen for ATTR-CA...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28982563/the-international-multicenter-trivalve-registry-which-patients-are-undergoing-transcatheter-tricuspid-repair
#17
Maurizio Taramasso, Rebecca T Hahn, Hannes Alessandrini, Azeem Latib, Adrian Attinger-Toller, Daniel Braun, Eric Brochet, Kim A Connelly, Paolo Denti, Florian Deuschl, Andrea Englmaier, Neil Fam, Christian Frerker, Joerg Hausleiter, Jean-Michel Juliard, Ryan Kaple, Felix Kreidel, Karl Heinz Kuck, Shingo Kuwata, Marco Ancona, Margarita Malasa, Tamim Nazif, Georg Nickenig, Fabian Nietlispach, Alberto Pozzoli, Ulrich Schäfer, Joachim Schofer, Robert Schueler, Gilbert Tang, Alec Vahanian, John G Webb, Ermela Yzeiraj, Francesco Maisano, Martin B Leon
OBJECTIVES: This study sought to develop a large, international registry to evaluate the diffusion of these approaches and investigate patient characteristics and initial clinical results. BACKGROUND: Several transcatheter tricuspid valve therapies are emerging as therapeutic options for patients with severe symptomatic tricuspid regurgitation (TR), generally a high-risk surgical population. METHODS: The TriValve (Transcatheter Tricuspid Valve Therapies) registry included 106 high-risk patients (76 ± 9 years of age; 60...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28977455/the-need-for-a-new-tricuspid-regurgitation-grading-scheme
#18
Rebecca T Hahn, Jose L Zamorano
No abstract text is available yet for this article.
December 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28973520/longitudinal-hemodynamics-of-transcatheter-and-surgical-aortic-valves-in-the-partner-trial
#19
Pamela S Douglas, Martin B Leon, Michael J Mack, Lars G Svensson, John G Webb, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, D Craig Miller, Samir Kapadia, Howard C Herrmann, Susheel K Kodali, Raj R Makkar, Vinod H Thourani, Stamatios Lerakis, Ashley M Lowry, Jeevanantham Rajeswaran, Matthew T Finn, Maria C Alu, Craig R Smith, Eugene H Blackstone
Importance: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective: To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Setting, and Participants: In this study, we analyzed core laboratory-generated data from echocardiograms of all patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1 Trial with successful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2, 3, 4, and 5 years postimplantation...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28973091/association-of-paravalvular-regurgitation-with-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-valve
#20
Philippe Pibarot, Rebecca T Hahn, Neil J Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar K Khalique, Federico M Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Maria Alu, Howard Herrmann, Raj Makkar, Michael Mack, Richard Smalling, Martin Leon, Vinod H Thourani, Susheel Kodali
Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves. Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve. Design, Setting, and Participants: Prespecified analysis of PVR in the Placement of Aortic Transcatheter Valves (PARTNER) II SAPIEN 3 trial, conducted between October 1, 2013, and September 3, 2014...
November 1, 2017: JAMA Cardiology
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