keyword
MENU ▼
Read by QxMD icon Read
search

ankylosing

keyword
https://www.readbyqxmd.com/read/29682062/dural-ectasia-and-cauda-equina-syndrome-a-rare-complication-of-long-standing-fusion
#1
Vrushali D Bachhav, Sumeet G Dua, Miral D Jhaveri
The clinicoradiological combination of cauda equina syndrome (CES) and dural ectasia is rare and has been described in a few of patients with ankylosing spondylitis (AS). Simultaneous occurrence of these entities in the absence of AS and in patients with long-standing spinal fusion is extremely rare. We present a case of dural ectasia and CES occurring as a long-term complication of instrumented spinal fusion and discuss the pathogenesis, imaging findings, and management options of this elusive disease process...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682039/chalkstick-fracture-a-catastrophic-injury
#2
Suryapratap Singh Tomar
Cervical spine region is known as very prone for injury because it is great mobility. Hyperflexion or hyperextension may create life-threatening injury to ankylosed cervical spine vertebra and spinal cord. The posttrauma result can range from neurological damage to the death. We present a case of a 52-year-old male patient, came to the emergency department with a history of road traffic accident induced quadriplegia and shock. The final diagnosis was chalkstick fracture of spine with complete cord transaction...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678847/diagnostic-value-of-vitamin-d-status-and-bone-turnover-markers-in-rheumatoid-arthritis-complicated-by-osteoporosis
#3
Li-Ming Tan, Ting-Ting Long, Xiao-Lin Guan, Si-Fan Wu, Wei Zheng, Hui-Ying Fu, Qiao-Hua Wang, Yi-Mei Meng, Yang Wu, Ting-Ting Zeng, Yong-Jian Tian, Jian-Lin Yu, Juan-Juan Chen, Hua Li, Li-Ping Cao
OBJECTIVE: To research the diagnostic performance of clinical potential bone turnover indexes in rheumatoid arthritis (RA) complicated with osteoporosis (OP). METHODS: This study involved 87 RA patients, 48 with OP, and 39 without OP, and 204 non-RA control patients, including those with systemic lupus erythematosus, ankylosing spondylitis, primary Sjogren's syndrome, systemic sclerosis, and healthy patients. The levels of 25-hydroxyvitamin D [25(OH)D], β-crosslaps (β-CROSSL), parathyroid hormone (PTH) were measured by electrochemiluminescence (ECLIA), and the level of bone alkaline phosphatase (BALP) was measured by lectin affinity method...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#4
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29676671/risk-factor-analysis-of-proximal-junctional-kyphosis-after-posterior-osteotomy-in-patients-with-ankylosing-spondylitis
#5
Tianhao Wang, Yongfei Zhao, Yan Liang, Haocong Zhang, Zheng Wang, Yan Wang
OBJECTIVE The aim of this paper was to analyze the incidence and risk factors of proximal junctional kyphosis (PJK) in patients with ankylosing spondylitis (AS) who underwent pedicle subtraction osteotomy. METHODS The records of 83 patients with AS and thoracolumbar kyphosis who underwent surgery at the authors' institution between 2007 and 2013 were reviewed. The patients were divided into 2 groups based on the presence or absence of PJK. The radiographic measurements, including proximal junctional angle (PJA), sagittal parameters, and pelvic parameters of these 2 groups, were compared at different time points: before surgery and 2 weeks, 12 months, and 2 years after surgery...
April 20, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29676028/treatment-of-ankylosing-spondylitis-with-co-amoxiclav
#6
Mesut Öğrendik
This article presents the efficacy of co-amoxiclav in two patients with ankylosing spondylitis. Both patients were administered oral co-amoxiclav for 7 days. The primary efficacy variable was the ankylosing spondylitis activity index. Secondary outcome measures were the ankylosing spondylitis functional index and spinal mobility. We detected a marked improvement in all symptoms and physical examination parameters. Co-amoxiclav has been shown to be effective against ankylosing spondylitis. This article is protected by copyright...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29675891/association-of-the-hla-b27-antigen-and-the-ctla4-gene-ct60-rs3087243-polymorphism-with-ankylosing-spondylitis-in-algerian-population-a-case-control-study
#7
C A Dahmani, A Benzaoui, H Amroun, F Mecabih, F Z Sediki, F Zemani-Fodil, M Fodil, W Boughrara, B Mecheti, N Attal, N Mehtar, E Petit-Teixeira, A Boudjema
Ankylosing spondylitis (AS) is a complex inflammatory disease that represents a major health problem both in Algeria and worldwide. Several lines of evidence support that genetic risk factors play a role in AS etiology and the CTLA4 gene has attracted a considerable attention. In this study, we were interested in evaluating the HLA-B27 frequency and in exploring the CTLA4 gene in a sample of the North African population. The dataset of the current study is composed of 81 patients with AS and 123 healthy controls...
April 19, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29672807/imaging-to-differentiate-the-various-forms-of-seronegative-arthritis
#8
Iris Eshed, Kay-Geert A Hermann, Anna Zejden, Iwona Sudoł-Szopińska
Spondyloarthritis (SpA) is a group of diseases characterized by back pain, spinal inflammation, human leukocyte antigen-B27 positivity, and peripheral findings such as dactylitis, enthesitis, and uveitis. It includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated SpA. The role of imaging in the diagnosis, management, and follow-up of patients with SpA has become dramatically more important with the introduction of new therapies such as tumor necrosis factor-α inhibitors...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29670761/improvements-in-workplace-and-household-productivity-with-certolizumab-pegol-treatment-in-axial-spondyloarthritis-results-to-week-96-of-a-phase-iii-study
#9
Désirée van der Heijde, Jürgen Braun, Martin Rudwaleit, Oana Purcaru, Arthur F Kavanaugh
Objectives: To evaluate the effect of certolizumab pegol (CZP) on work and household productivity, and on participation in family, social and leisure activities in patients with axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-) axSpA. Methods: RAPID-axSpA (NCT01087762) was a phase III, double-blind, placebo-controlled trial to week (Wk) 24, dose-blind to Wk48 and open-label to Wk204. A total of 325 patients were randomised 1:1:1 to placebo, CZP 200 mg Q2W or CZP 400 mg Q4W...
2018: RMD Open
https://www.readbyqxmd.com/read/29670461/role-of-interleukin-il-17-in-the-pathogenesis-and-targeted-therapies-in-spondyloarthropathies
#10
REVIEW
I-Tsu Chyuan, Ji-Yih Chen
Spondyloarthropathy (SpA) is a unique type of joint inflammation characterized by coexisting erosive bone damage and pathological new bone formation. Previous genetic association studies have demonstrated that several cytokine pathways play a critical role in the pathogenesis of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and other types of SpA. In addition to several well-known proinflammatory cytokines, recent studies suggest that IL-17 plays a pivotal role in the pathogenesis of SpA. Further evidence from human and animal studies have defined that IL-17 and IL-17-producing cells contribute to tissue inflammation, autoimmunity, and host defense, leading to the following pathologic events associated with SpA...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29669197/complications-of-total-hip-arthroplasty-in-patients-with-ankylosing-spondylitis
#11
Michael M Ward
BACKGROUND: To compare the risks of complications of primary total hip arthroplasty (THA) between patients with ankylosing spondylitis (AS) and those without AS. METHODS: In this population-based study, we examined U.S. Medicare beneficiaries (< 75 years old) with AS and a comparison group without AS who had primary THA in 1999 - 2013. Complications were based on the 2013 Centers for Medicare & Medicaid Services THA Complication Measure, which included myocardial infarction, pneumonia, and sepsis within 7 days; surgical site bleeding, pulmonary embolus, or venous thrombosis within 30 days; and mechanical complications or local infection within 90 days...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668128/tuberculosis-associated-with-tumor-necrosis-factor-%C3%AE-antagonists-case-description-and-analysis-of-reported-cases-in-colombia
#12
Leandro Galvis, Ángel Y Sánchez, Leonardo F Jurado, Martha I Murcia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667099/analysis-of-relapse-rates-and-risk-factors-of-tapering-or-stopping-pharmacologic-therapies-in-axial-spondyloarthritis-patients-with-sustained-remission
#13
Xiaochan Chen, Ting Zhang, Wenwen Wang, Jing Xue
The objectives of this study are to evaluate whether tapering or stopping strategies of pharmacologic therapies are efficacious for maintaining remission in patients with axial spondyloarthritis (axSPA) and to analyze the risk factors of disease relapse. Patients diagnosed as axSPA with ankylosing spondylitis disease activity score based on C reactive protein (ASDAS-CRP) ≤2.0 for at least 3 months were randomized into three groups: continuing non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs) (group 1), tapering NSAIDs and DMARDs by 50% (group 2), or discontinuing NSAIDs and DMARDs (group3) after 6 months of tapering...
April 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29667098/treatment-patterns-among-patients-with-rheumatic-disease-rheumatoid-arthritis-ra-ankylosing-spondylitis-as-psoriatic-arthritis-psa-and-undifferentiated-arthritis-una-treated-with-subcutaneous-tnf-inhibitors
#14
Kathleen Tymms, Geoff Littlejohn, Hedley Griffiths, Julien de Jager, Paul Bird, Fred Joshua, Peter Nash, Malcolm Handel, Hamish McManus, Belinda E Butcher, Peter Youssef
The aim was to describe the real-world treatment persistence of subcutaneous TNF inhibitors (TNFi) for patients with inflammatory rheumatic disease newly initiating treatment with biologic disease-modifying antirheumatic drugs (bDMARD). This was a retrospective cohort study that extracted data for new users of TNFi between 1 August 2010 and 31 August 2016 from the Australian Optimising Patient outcome in Australian RheumatoLogy (OPAL) registry. Patients were 1:1 propensity-score matched with golimumab based on their age, sex, year of index, C-reactive protein level, baseline treatment combination and disease...
April 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29667047/investigation-of-the-mechanism-of-therapeutic-protein-drug-interaction-between-methotrexate-and-golimumab-an-anti-tnf%C3%AE-monoclonal-antibody
#15
Weirong Wang, Jocelyn Leu, Rebecca Watson, Zhenhua Xu, Honghui Zhou
A prominent example of human therapeutic protein-drug interaction (TP-DI) is between methotrexate (MTX) and anti-TNFα mAbs. One plausible mechanism for this TP-DI is through the pharmacodynamic effect of MTX on immunogenicity. However, there is no definitive evidence to substantiate this mechanism, and other competing hypotheses, such as MTX suppressing FcγRI expression thereby affecting mAb PK, have also been proposed. In order to understand this mechanism, a cynomolgus monkey study was conducted using golimumab as a model compound...
April 17, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29666980/epidemiology-of-uveitis-in-a-us-population-based-study
#16
Marta Mora González, Marissé Masís Solano, Travis C Porco, Catherine E Oldenburg, Nisha R Acharya, Shan C Lin, Matilda F Chan
BACKGROUND: The purpose of this study is to assess the relationship between self-reported uveitis and purported demographic and clinical risk factors, using an American adult population extracted from the National Health and Nutrition Examination Survey (NHANES) for the years 2009 and 2010. This is a cross-sectional, population-based study using a sample of 5106 subjects between 20 and 69 years old. The main outcome for our study was the self-report of a diagnosis of uveitis. The demographic analysis included age, gender, and ethnicity...
April 17, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29666723/a-challenging-case-of-severe-ulcerative-colitis-following-the-initiation-of-secukinumab-for-ankylosing-spondylitis
#17
Dean Ehrlich, Nimah Jamaluddin, Joseph Pisegna, David Padua
Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29666651/relative-risk-chart-score-for-the-assessment-of-the-cardiovascular-risk-in-young-patients-with-ankylosing-spondylitis
#18
Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata Arnaiz, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez, Miguel A González-Gay
Objective: To determine if the use of the relative risk (RR) chart score may help to identify young ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease. Methods: 73 AS patients younger than 50 years were assessed. CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) and the RR chart score. C-reactive protein (CRP) value at disease diagnosis and carotid ultrasound data were also analyzed...
2018: International Journal of Rheumatology
https://www.readbyqxmd.com/read/29665824/inflammatory-back-pain-in-psoriatic-arthritis-is-significantly-more-responsive-to-corticosteroids-compared-to-back-pain-in-ankylosing-spondylitis-a-prospective-open-labelled-controlled-pilot-study
#19
Muhammad Haroon, Muddassar Ahmad, Muhammad Nouman Baig, Olivia Mason, John Rice, Oliver FitzGerald
BACKGROUND: The efficacy of corticosteroids in patients with psoriatic arthritis (PsA) and inflammatory back pain has not been studied to date. In this controlled trial, we aimed to investigate the comparative performance of corticosteroids in patients with active axial-PsA (AxPsA) versus those with active ankylosing spondylitis (AS). METHODS: Patients with AxPsA and AS (naïve to biologic therapies), who not only had clinically active disease, but also had bone marrow oedema on magnetic resonance imaging of the sacroiliac joints, were recruited...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29663162/functional-defects-of-treg-cells-new-targets-in-rheumatic-diseases-including-ankylosing-spondylitis
#20
REVIEW
Jinlin Miao, Ping Zhu
PURPOSE OF REVIEW: This study aims to review the advances of Treg cell biology, the functional defects of Treg cells, and the potential strategies for the experimental, preclinical or clinical application of Treg cell therapy in the context of autoimmune/immune-mediated rheumatic diseases. RECENT FINDINGS: CD4+ CD25+ regulatory T (Treg) cells are a phenotypically and functionally heterogeneous subset of lymphocytes that prevent a variety of autoimmune diseases. As in many autoimmune diseases, the functional defects of Treg cells are supposed to play relevant roles in the pathogenesis and development of systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and other autoimmune/immune-mediated rheumatic diseases...
April 16, 2018: Current Rheumatology Reports
keyword
keyword
37230
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"