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https://www.readbyqxmd.com/read/29240803/bone-edema-on-magnetic-resonance-imaging-is-highly-associated-with-low-bone-mineral-density-in-patients-with-ankylosing-spondylitis
#1
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29240213/minimally-invasive-treatment-of-an-ankylosed-severely-discolored-and-intruded-central-incisor-with-a-masking-ceramic-veneer-a-clinical-report
#2
Anja Liebermann, Daniel Edelhoff, Otto Prandtner, Reza Saeidi Pour
Dental therapy of traumatically ankylosed maxillary anterior teeth with an additional slight root resorption represents a great challenge for the restorative team and requires intensive planning and communication between patient, dentist, orthodontist, periodontist, and dental technician. The inhibition of vertical growth often makes dental intervention indispensable. Porcelain laminate veneers have been successfully used for more than two decades, mainly on anterior teeth, and was the minimally invasive treatment option for the present case report...
January 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29238018/-regulation-of-bone-by-il-17-producing-t-cells
#3
Kazuo Okamoto
  Bone is a component of the skeletal-locomotor system but also functions as an immunological organ that harbors hematopoietic stem and progenitor cells. Since the immune and skeletal systems are closely related through a number of shared regulatory molecules including cytokines and receptors, bone can be affected in various immune disorders. Rheumatoid arthritis is a typical disease in which the immune system affects the bone metabolism. The enhanced activity of osteoclasts by the activation of Th17 cells causes the joint destruction in rheumatoid arthritis...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29230494/association-of-polymorphisms-in-tnf-and-grn-genes-with-ankylosing-spondylitis-in-a-chinese-han-population
#4
Naiwen Hu, Yazhou Cui, Qingrui Yang, Liya Wang, Xinglin Yang, Hongzhi Xu
The aim of this study is to investigate the association of the polymorphisms in tumor necrosis factor (TNF) and granulin (GRN) with ankylosing spondylitis (AS) in a Chinese Han population. Five single nucleotide polymorphisms (SNPs) covering TNF and six SNPs covering GRN were investigated in 861 Chinese Han AS patients and 864 healthy controls. For rs1799964, the C allele was linked to reduced risk of AS (p < 0.0001, OR = 0.60, 95% CI = 0.50-0.71). The carriers of the C/C homozygote showed a significantly lower risk of AS compared with the TT homozygote and the C/T heterozygote under the recessive model (p < 0...
December 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29228588/interleukin-17a-promoted-msc2-polarization-related-with-new-bone-formation-of-ankylosing-spondylitis
#5
Tao He, Yan Huang, Chen Zhang, Denghui Liu, Chao Cheng, Weidong Xu, Xiaoling Zhang
It's still unknown how over-hyperplasia of tissue such like new bone formation (NBF) developed in ankylosing spondylitis (AS). We found low level of IL-17A promoted TLR4+MSC1 polarization with suppressed osteogenic differentiation through JAK2/STAT3 pathway, while high level of IL-17A promoted TLR3+MSC2 polarization with enhanced osteogenic differentiation through WNT10b/RUNX2 pathway. Furthermore, both proteoglycan-induced spondylitis (PGISp) mouse model and AS patients without NBF showed MSC1 polarization, up-regulated JAK2/STAT3 pathway and high level of IL-17A (peripherally, but not locally), but those with NBF showed MSC2 polarization, up-regulated WNT10b/RUNX2 pathway and high expression of IL-17A at local site...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227352/epidemiology-of-axial-spondyloarthritis-an-update
#6
Runsheng Wang, Michael M Ward
PURPOSE OF REVIEW: To provide an update of the prevalence and incidence of axial spondyloarthritis in the general population and in patients with spondyloarthritis-related conditions, environmental risk factors for ankylosing spondylitis, progression from nonradiographic axial spondyloarthritis to ankylosing spondylitis, mortality, and risks for cardiovascular events in patients with ankylosing spondylitis. RECENT FINDINGS: Increasingly, administrative healthcare data have been used to study disease frequency and outcomes...
December 8, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29222625/using-patient-feedback-to-optimize-the-design-of-a-certolizumab-pegol-electromechanical-self-injection-device-insights-from-human-factors-studies
#7
Barbara Domańska, Oliver Stumpp, Steven Poon, Serkan Oray, Irina Mountian, Clovis Pichon
INTRODUCTION: We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP). METHODS: Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or Crohn's disease participated in 11 formative HFS to optimize the e-Device design through intended user feedback; nine studies involved simulated injections...
December 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29217947/coexistence-of-peripheral-spondyloarthritis-and-familial-adenomatous-polyposis-a-rare-case-report-with-treatment-contradictions-and-review-of-the-literature
#8
Berna Urkmez, Muge Kepekci, Sevde Ozer Posul, Aylin Rezvani
Background: The coexistence of familial adenomatous polyposis and spondyloarthritis is rarely defined in literature. The primary aim of this presentation is to report a development of peripheral arthritis in 3 years following colon surgery with the diagnosis of familial adenomatous polyposis (FAP). The secondary aim is to discuss the challenge of in treatment of refractory arthritis, which needs to be treated with biologics. However, it is not yet known well about their safety on patients who have risks for cancer development...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29216909/which-measuring-site-in-ankylosing-spondylitis-is-best-to-detect-bone-loss-and-what-predicts-the-decline-results-from-a-5-year-prospective-study
#9
Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T Jacobsson, Helena Forsblad-d'Elia
BACKGROUND: Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine anterior-posterior (AP) projection may be difficult to interpret due to the ligamentous calcifications, and the lateral projection might be a better measuring site. Our objectives were to investigate BMD changes after 5 years at different measuring sites in patients with AS and to evaluate disease-related variables and medications as predictors for BMD changes...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29213122/spondyloarthropathies-tnf-inhibitors-and-structural-damage-in-ankylosing-spondylitis
#10
Atul Deodhar
No abstract text is available yet for this article.
December 7, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29212085/the-impact-of-anti-tnf-therapy-on-cd4-and-cd8-cell-subsets-in-ankylosing-spondylitis
#11
Sonja Dulic, Zsofia Vasarhelyi, Anna Bajnok, Balazs Szalay, Gergely Toldi, Laszlo Kovacs, Attila Balog
OBJECTIVES: Ankylosing spondylitis (AS) is a chronic, progressive immune-mediated inflammatory disease, driven primarily by Th1 and Th17 cells. Anti-TNF therapies are successfully used in AS to achieve and maintain remission. However, their influence on the composition of T-cell subsets is not clear. We aimed to characterize the changes in the T-cell repertoire after a long-term anti-TNF treatment in AS patients. METHODS: Twenty-two AS patients under long-term anti-TNF therapy were evaluated (15 anti-TNF responders and 7 nonresponders)...
December 6, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29210147/drug-exposure-and-the-risk-of-multiple-sclerosis-a-systematic-review
#12
REVIEW
Heather Y Yong, Kyla A McKay, Cole G J Daley, Helen Tremlett
BACKGROUND: Several environmental and lifestyle factors have been associated with multiple sclerosis (MS) risk, including some pharmacological treatments. We systematically reviewed the literature on prescription drug exposure and MS risk. METHODS: Six databases were searched for original observational studies reporting drug exposure and MS risk published before 2017. RESULTS: Thirteen articles fulfilled inclusion criteria. Exposure to neither amiloride nor valproic acid was associated with MS (adjusted hazard ratio (adj...
December 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29207750/validity-of-simplified-ankylosing-spondylitis-disease-activity-scores-sasdas-in-indian-ankylosing-spondylitis-patients
#13
Nagma Bansal, Lalit Duggal, Neeraj Jain
Introduction: Ankylosing Spondylitis Disease Activity Score (ASDAS) is a complex score for monitoring disease activity in Ankylosing Spondylitis (AS). Aim: To develop a simplified version of the ASDAS. Materials and Methods: Consenting 254 AS patients (modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria) were recruited. Sociodemographic data and disease characteristics such as Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and AS Quality of Life (ASQoL), Erythrocyte Sedimentation Rate (ESR), and C-Reactive Protein (CRP) were collected...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207654/genetic-variations-in-light-are-associated-with-susceptibility-to-ankylosing-spondylitis-in-a-chinese-han-population
#14
Bin Yang, Junlong Zhang, Lixin Li, Xiaojun Lyu, Wei Wei, Zhuochun Huang, Bei Cai, Lanlan Wang
Ankylosing spondylitis (AS) is a common chronic autoimmune disease characterized by inflammation of axial skeleton and has strong genetic susceptibility. Single nucleotide polymorphisms (SNPs) have been found playing an important role in the development of AS. This study intends to explore whether the susceptibility to AS is associated with rs2171513 C>T, rs1077667 G>A in LIGHT (lymphotoxin, expressed on T lymphocytes) and rs12609318 A>G in B and T lymphocyte attenuator (BTLA) in a Chinese Han population...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207198/mechanism-of-triptolide-in-treating-ankylosing-spondylitis-through-the-anti%C3%A2-ossification-effect-of-the-bmp-smad-signaling-pathway
#15
Guilong Wang, Jing Cai, Jinshan Zhang, Cuiyun Li
The present study aimed to examine the mechanism of triptolide in the treatment of ankylosing spondylitis (AS) through the anti‑ossification effect of bone morphogenetic protein (BMP)/small mothers against decapentaplegic (Smad) pathway. Male rats were randomly divided into five groups: Normal rat group; model group; triptolide low dose group (10 mg/kg); triptolide middle dose group (20 mg/kg); triptolide high dose group (40 mg/kg). The spinal joint capsules of each group of rats were collected to perform primary cell culture to determine the levels of cell proliferation...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204490/lumbar-chance-fracture-after-direct-anterior-total-hip-arthroplasty
#16
Michael Pitta, Corey J Wallach, Colleen Bauk, William G Hamilton
This report describes a patient with ankylosing spondylitis (AS) who underwent total hip arthroplasty (THA) by the direct anterior approach and sustained a L4-5 extension fracture dislocation with neural deficits. A magnetic resonance imaging revealed an epidural hematoma at the site of the fracture causing critical stenosis. The patient was taken to the operating room for a L3-S1 posterior decompression with L2-pelvis posterior spinal fusion. AS and diffuse idiopathic skeletal hyperostosis create a stiff spine that predisposes to fractures because of the larger moment arms experienced than normal spines...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29202535/-the-safety-and-efficacy-of-golimumab-in-treatment-of-25-patients-with-active-ankylosing-spondylitis
#17
H Ma, F Sun, Y M Zhang, H Zhang, J Zhu, X H Deng, J L Zhang, F Huang
Objective: To evaluate the efficacy and safety of golimumab in patients with active ankylosing spondylitis (AS). Methods: This was a randomized, double-blind, placebo-controlled trial. The subjects were randomized to receive either golimumab 50mg subcutaneously or placebo every 4 weeks. Patients in both groups received golimumab 50mg from week 24 to week 48. The primary endpoint was the proportion of at least 20% improvement in the Assessment of Spondyloarthritis International Society (ASAS20) at week 14. The secondary endpoints included at least 40% improvement in the Assessment of Spondyloarthritis International Society (ASAS40), ASAS partial-remission, Bath AS functional index, Bath AS disease activity index, Bath AS metrology index, enthesitis index and Jenkins sleep evaluation questionnaire...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29201209/correlation-of-the-expression-of-mir-146a-in-peripheral-blood-mononuclear-cells-of-patients-with-ankylosing-spondylitis-and-inflammatory-factors
#18
Chengjun Wei, Hongxia Zhang, Chenghong Wei, Youyan Mao
We investigated the expression of miR-146a in peripheral blood mononuclear cell (PBMC) of patients with ankylosing spondylitis (AS) and its correlation with inflammatory factors to explore the clinical significance. In total 45 patients with AS were selected at the Weifang People's Hospital from June, 2014 to January, 2016. At the same time, 30 healthy volunteers were also selected to serve as control group. Expression level of miR-146a in PBMC cells of patients in each group was detected by quantitative real-time-polymerase chain reaction (qRT-PCR)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200482/computer-simulation-of-two-level-pedicle-subtraction-osteotomy-for-severe-thoracolumbar-kyphosis-in-ankylosing-spondylitis
#19
Ning Zhang, Hao Li, Zheng-Kuan Xu, Wei-Shan Chen, Qi-Xin Chen, Fang-Cai Li
Background: Advanced ankylosing spondylitis is often associated with thoracolumbar kyphosis, resulting in an abnormal spinopelvic balance and pelvic morphology. Different osteotomy techniques have been used to correct AS deformities, unfortunnaly, not all AS patients can gain spinal sagittal balance and good horizontal vision after osteotomy. Materials and Methods: Fourteen consecutive AS patients with severe thoracolumbar kyphosis who were treated with two-level PSO were studied retrospectively...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29200018/the-diagnostic-and-prognostic-role-of-interleukin-12b-and-interleukin-6r-gene-polymorphism-in-patients-with-ankylosing-spondylitis
#20
Wen-Feng Ruan, Jiang-Tao Xie, Qi Jin, Wen-Da Wang, An-Song Ping
OBJECTIVES: Interleukin 23 (IL-23) pathway and IL-1 cluster genes play prominent role in the etiopathology of ankylosing spondylitis (AS). The aim of this study was to investigate the diagnostic and prognostic role of 5 single-nucleotide polymorphisms related to IL-23 pathway and IL-1 cluster genes in AS patients. METHODS: Four hundred thirty-one patients with AS and 206 age- and sex-matched healthy controls were recruited in this prospective cohort study. Five potential single-nucleotide polymorphisms (IL-23R [rs11209026], IL-12B [rs6871626], TYK2 [rs6511701], IL-6R [rs4129267], and IL-1R2 [rs2192752]) related to IL-23 pathway and IL-1 cluster genes by analyzing previous studies were genotyped...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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