Ryan J Keenan, Heather Daykin, Jeremy Metha, Linda Cornthwaite-Duncan, David K Wright, Kyra Clarke, Sara Oberrauch, Maddison Brian, Sarah Stephenson, Cameron J Nowell, Giancarlo Allocca, Kevin J Barnham, Daniel Hoyer, Laura H Jacobson
BACKGROUND AND PURPOSE: Tau pathology contributes to a bidirectional relationship between sleep disruption and neurodegenerative disease. Tau transgenic rTg4510 mice model tauopathy symptoms including sleep/wake disturbances, which manifest as marked hyperarousal. This phenotype can be prevented by early transgene suppression, however, whether hyperarousal can be rescued after its onset is unknown. EXPERIMENTAL APPROACH: Three chronic (8-week) experiments were conducted with wild-type and rTg4510 mice after the age of onset of hyperarousal (4...
August 8, 2023: British Journal of Pharmacology