Motohiro Ozone, Susumu Hirota, Yu Ariyoshi, Kenichi Hayashida, Azusa Ikegami, Mitsunari Habukawa, Hayato Ohshima, Daisuke Harada, Hiroshi Hiejima, Nozomu Kotorii, Kenta Murotani, Takehiro Taninaga, Naohisa Uchimura
INTRODUCTION: For patients with chronic insomnia, conventional therapy may not always provide satisfactory efficacy and safety. Thus, switching to an alternative therapeutic agent can be explored. However, there is a lack of prospective studies evaluating the effectiveness of such changes. This prospective, non-randomized, open-label, interventional, multicenter study assessed whether Japanese patients with chronic insomnia dissatisfied with treatment could transition directly to lemborexant (LEM) from four cohorts-non-benzodiazepine sedative-hypnotic (zolpidem, zopiclone, or eszopiclone) monotherapy, dual orexin receptor antagonist (suvorexant) monotherapy, suvorexant + benzodiazepine receptor agonists (BZRAs), and melatonin receptor agonist (ramelteon) combination...
March 9, 2024: Advances in Therapy