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https://www.readbyqxmd.com/read/29356403/do-sex-reversal-procedures-differentially-affect-agonistic-behaviors-and-sex-steroid-levels-depending-on-the-sexual-genotype-in-nile-tilapia
#1
Vincent Gennotte, Balagizi Akonkwa, Charles Mélard, Mathieu Denoël, Charlotte A Cornil, Carole Rougeot
In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioral and physiological traits. Compared to natural XX females and XY males, XY and YY females and XX males expressed higher level of aggressiveness that could be related to higher levels of 17β-estradiol and 11-ketotestosterone, respectively. Our results suggest that the presence of a Y chromosome increases aggressiveness in females. However, since the same relationship between aggressiveness and the Y chromosome is not observed in males, we can hypothesize that the differences in aggressiveness are not directly dependent on the genotype but on the sex reversal procedures applied on young fry during their sexual differentiation to produce these breeders...
April 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29355667/wound-healing-in-the-eye-therapeutic-prospects
#2
Mohammed Ziaei, Carol Greene, Colin R Green
In order to maintain a smooth optical surface the corneal epithelium has to continuously renew itself so as to maintain its function as a barrier to fluctuating external surroundings and various environmental insults. After trauma, the cornea typically re-epithelializes promptly thereby minimizing the risk of infection, opacification or perforation. A persistent epithelial defect (PED) is usually referred to as a non-healing epithelial lesion after approximately two weeks of treatment with standard therapies to no avail...
January 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29355551/baseline-and-serial-brain-natriuretic-peptide-level-predicts-5-year-overall-survival-in-patients-with-pulmonary-arterial-hypertension-data-from-the-reveal-registry
#3
Robert P Frantz, Harrison W Farber, David B Badesch, C Greg Elliott, Adaani E Frost, Michael D McGoon, Carol Zhao, David R Mink, Mona Selej, Raymond L Benza
BACKGROUND: Plasma brain natriuretic peptide (BNP) level is a prognostic biomarker in pulmonary arterial hypertension (PAH). Its impact on long-term overall survival (OS) was investigated in REVEAL, a 5-year observational, multicenter, United States registry of patients with PAH. METHODS: Patients were aged ≥18 years, met right heart catheterization criteria at rest, had WHO Group I PAH, and BNP measurement at enrollment. Optimal BNP threshold was obtained via receiver operating characteristic curve analysis...
January 16, 2018: Chest
https://www.readbyqxmd.com/read/29355550/research-in-extracorporeal-life-support-a-call-to-action
#4
Daniel Brodie, Vincent Jean-Louis, Laurent J Brochard, Alain Combes, Niall D Ferguson, Carol L Hodgson, John G Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S Slutsky, V Marco Ranieri
No abstract text is available yet for this article.
January 17, 2018: Chest
https://www.readbyqxmd.com/read/29355391/updated-molecular-testing-guideline-for-the-selection-of-lung-cancer-patients-for-treatment-with-targeted-tyrosine-kinase-inhibitors-guideline-from-the-college-of-american-pathologists-the-international-association-for-the-study-of-lung-cancer-and-the-association
#5
Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, Murry W Wynes, Yasushi Yatabe
CONTEXT: - In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology to set standards for the molecular analysis of lung cancers to guide treatment decisions with targeted inhibitors. New evidence has prompted an evaluation of additional laboratory technologies, targetable genes, patient populations, and tumor types for testing. OBJECTIVE: - To systematically review and update the 2013 guideline to affirm its validity; to assess the evidence of new genetic discoveries, technologies, and therapies; and to issue an evidence-based update...
January 22, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29355128/the-effect-of-load-on-biomechanics-of-the-back-and-upper-limb-in-a-bench-to-shoulder-lift-during-the-workhab-functional-capacity-evaluation
#6
Nathanael West, Suzanne J Snodgrass, Carole James
BACKGROUND: Limited literature exists investigating biomechanical changes during a Functional Capacity Evaluation (FCE). OBJECTIVE: To determine change in joint angle measurement between minimum load to safe maximum load in the bench to shoulder lift of the WorkHab FCE. METHODS: Dartfish ProSuite was used to analyse bench to shoulder lift video from 28 subjects. Measurements of joint angle at lumbar spine, thoracic spine, elbow and shoulder at four points in the ascending and descending lift phases (0/3, 1/3, 2/3, 3/3) in the minimum load and safe maximum lift were collected...
January 18, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29355120/task-rotation-in-an-underground-coal-mine-a-pilot-study
#7
Olivia F Jones, Carole L James
BACKGROUND: Task rotation is used to decrease the risk of workplace injuries and improve work satisfaction. OBJECTIVE: To investigate the feasibility, benefits and challenges of implementing a task rotation schedule within an underground coalmine in NSW, Australia. METHODS: A mixed method case control pilot study with the development and implementation of a task rotation schedule for 6 months with two work crews. A questionnaire including The Nordic Musculoskeletal Questionnaire, The Need for Recovery after Work Scale, and The Australian WHOQOL- BREF Australian Edition was used to survey workers at baseline, 3 and 6 months...
January 18, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29355045/cardio-oncology-an-evolving-hybrid-subspecialty
#8
Carol Chen-Scarabelli, William G Hundley, Tiziano M Scarabelli
No abstract text is available yet for this article.
January 22, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29355027/leisure-time-physical-activity-subjective-age-and-self-rated-memory-in-middle-aged-and-older-adults
#9
Yen T Chen, Carole K Holahan, Charles J Holahan, Xiaoyin Li
Memory concerns are common in middle-aged and older adults. This study investigated the relation of leisure-time physical activity to self-rated memory and the possible mediating role of subjective age in this relationship in middle-aged and older adults. Cross-sectional analyses were conducted with a sample of 1,608 middle-aged and older adults from the second wave of the National Survey of Midlife Development in the United States (MIDUS2). In a path analysis conducted with Mplus, a higher level of leisure-time physical activity was associated with a more positive appraisal of memory compared to others of one's age; younger subjective age partially mediated this relationship...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29353512/social-disadvantage-severe-child-abuse-and-biological-profiles-in-adulthood
#10
Chioun Lee, Christopher L Coe, Carol D Ryff
Guided by the stress process model and the life course perspective, we hypothesize: (1) that childhood abuse is concentrated, in terms of type and intensity, among socially disadvantaged individuals, and (2) that experiencing serious abuse contributes to poor biological profiles in multiple body systems in adulthood. Data came from the Biomarker subsample of Midlife in the United States (2004-2006). We used latent class analysis to identify distinct profiles of childhood abuse, each reflecting a combination of type and severity...
September 2017: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29353445/hypermethylation-of-nf-%C3%AE%C2%BAb-activating-protein-like-nkapl-promoter-in-hepatocellular-carcinoma-suppresses-its-expression-and-predicts-a-poor-prognosis
#11
Patrick Kwok Shing Ng, Carol Po Ying Lau, Emily Kai Yee Lam, Sheila Sai Kam Li, Vivian Wai Yan Lui, Winnie Yeo, Yuen Keng Ng, Paul Bo San Lai, Stephen Kwok Wing Tsui
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate partially due to frequent recurrence and no efficient therapy. Promoter hypermethylation of tumor suppressor genes has been demonstrated as one of the molecular mechanisms contributing to tumorigenesis and progression in HCC. This study aims to investigate regulation of NKAPL expression by promoter methylation and its clinical relevance as a biomarker for HCC. METHODS: We measured mRNA expression of NKAPL in 5 HCC cell lines and a cohort of 62 pairs of primary HCC tumor and their adjacent non-cancer liver tissues...
January 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29353183/automatic-bad-channel-detection-in-intracranial-electroencephalographic-recordings-using-ensemble-machine-learning
#12
Viateur Tuyisenge, Lena Trebaul, Manik Bhattacharjee, Blandine Chanteloup-Forêt, Carole Saubat-Guigui, Ioana Mîndruţă, Sylvain Rheims, Louis Maillard, Philippe Kahane, Delphine Taussig, Olivier David
OBJECTIVE: Intracranial electroencephalographic (iEEG) recordings contain "bad channels", which show non-neuronal signals. Here, we developed a new method that automatically detects iEEG bad channels using machine learning of seven signal features. METHODS: The features quantified signals' variance, spatial-temporal correlation and nonlinear properties. Because the number of bad channels is usually much lower than the number of good channels, we implemented an ensemble bagging classifier known to be optimal in terms of stability and predictive accuracy for datasets with imbalanced class distributions...
December 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29353127/physical-comorbidities-increase-the-risk-of-psychiatric-comorbidity-in-immune-mediated-inflammatory-disease
#13
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We tested the association between physical comorbidity and incident depression, anxiety disorder and bipolar disorder in three immune-mediated inflammatory diseases (IMID): inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) versus age-, sex- and geographically-matched controls. METHODS: Using population-based administrative data we identified 6119 persons with IBD, 3514 persons with MS, 10,206 persons with RA and 97,727 matched controls...
January 11, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29353109/shortened-duration-tacrolimus-after-nonmyeloablative-hla-haploidentical-bmt
#14
Yvette L Kasamon, Ephraim J Fuchs, Marianna Zahurak, Gary L Rosner, Heather J Symons, Douglas E Gladstone, Carol Ann Huff, Lode J Swinnen, Robert A Brodsky, William H Matsui, Ivan Borrello, Satish Shanbhag, Kenneth R Cooke, Richard F Ambinder, Leo Luznik, Javier Bolaños-Meade, Richard J Jones
With posttransplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis, nonmyeloablative HLA-haploidentical (NMA haplo) and HLA-matched blood or marrow transplantation (BMT) have comparable outcomes. Early discontinuation of immunosuppression may reduce relapse, as well as improve immune reconstitution, but may increase GVHD. We conducted a prospective trial of NMA haplo BMT for patients with hematologic malignancies (median age, 61), evaluating the safety of early discontinuation of tacrolimus...
January 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29352849/impact-of-vasculitis-on-employment-and-income
#15
Lillian Barra, Renée L Borchin, Cristina Burroughs, George C Casey, Carol A McAlear, Antoine G Sreih, Kalen Young, Peter A Merkel, Christian Pagnoux
OBJECTIVES: Work disability associated with rheumatic diseases accounts for a substantial financial burden. However, few studies have investigated disability among patients with vasculitis. The purpose of this study was to examine the impact of vasculitis on patient employment and income. METHODS: Patients enrolled in the Vasculitis Clinical Research Consortium (VCRC) Patient Contact Registry, living in the USA or Canada, and followed for >1 year post-diagnosis, participated in an online survey-based study...
January 10, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352569/patient-navigation-reduces-time-to-care-for-patients-with-breast-symptoms-and-abnormal-screening-mammograms
#16
Elaine McKevitt, Carol Dingee, Rebecca Warburton, Jin-Si Pao, Carl J Brown, Christine Wilson, Urve Kuusk
INTRODUCTION: Concern has been raised about delays for patients presenting with breast symptoms in Canada. Our objective was to determine if our Rapid Access Breast Clinic (RABC) improved care for patients presenting with breast symptoms compared to the traditional system (TS). METHODS: A retrospective chart review tabulated demographic, surgical, pathology and radiologic information. Wait times to care were determined for patients presenting with symptomatic and screen detected breast problems...
January 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29352295/correction-stakeholders-views-and-experiences-of-care-and-interventions-for-addressing-frailty-and-pre-frailty-a-meta-synthesis-of-qualitative-evidence
#17
Barbara D'Avanzo, Rachel Shaw, Silvia Riva, Joao Apostolo, Elzbieta Bobrowicz-Campos, Donata Kurpas, Maria Bujnowska-Fedak, Carol Holland
[This corrects the article DOI: 10.1371/journal.pone.0180127.].
2018: PloS One
https://www.readbyqxmd.com/read/29351445/impact-of-hiv-infection-on-alpha-1-antitrypsin-in-the-lung
#18
Sarah E Stephenson, Carole L Wilson, Kristina Crothers, Engi F Attia, Cherry Wongtrakool, Irina Petrache, Lynn M Schnapp
BACKGROUND: Emphysema is one of the most common lung diseases in HIV+ individuals. The pathogenesis of HIV-associated emphysema remains unclear; however, radiographic distribution and earlier age of presentation of emphysema in the lungs of HIV+ patients are similar to deficiency of alpha-1 antitrypsin (A1AT), a key elastase inhibitor in the lung. Reduced levels of circulating A1AT have been detected in HIV+ patients, suggesting a potential mechanism for emphysema development. In the present study, we asked if A1AT levels and activity in the bronchoalveolar lavage fluid (BALF) differ in patients with and without HIV and emphysema...
December 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29351294/a-had-family-phosphatase-csp-6-regulates-the-circadian-output-pathway-in-neurospora-crassa
#19
Xiaoying Zhou, Bin Wang, Jillian M Emerson, Carol S Ringelberg, Scott A Gerber, Jennifer J Loros, Jay C Dunlap
Circadian clocks are ubiquitous in eukaryotic organisms where they are used to anticipate regularly occurring diurnal and seasonal environmental changes. Nevertheless, little is known regarding pathways connecting the core clock to its output pathways. Here, we report that the HAD family phosphatase CSP-6 is required for overt circadian clock output but not for the core oscillation. The loss of function Δcsp-6 deletion mutant is overtly arrhythmic on race tubes under free running conditions; however, reporter assays confirm that the FREQUENCY-WHITE COLLAR COMPLEX core circadian oscillator is functional, indicating a discrete block between oscillator and output...
January 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29351200/comparing-nutrient-removal-from-membrane-filtered-and-unfiltered-domestic-wastewater-using-chlorella-vulgaris
#20
Elyssia Mayhead, Alla Silkina, Carole A Llewellyn, Claudio Fuentes-Grünewald
The nutrient removal efficiency of Chlorella vulgaris cultivated in domestic wastewater was investigated, along with the potential to use membrane filtration as a pre-treatment tool during the wastewater treatment process. Chlorella vulgaris was batch cultivated for 12 days in a bubble column system with two different wastewater treatments. Maximum uptake of 94.18% ammonium (NH₄-N) and 97.69% ortho-phosphate (PO₄-P) occurred in 0.2 μm membrane filtered primary wastewater. Membrane filtration enhanced the nutrient uptake performance of C...
January 19, 2018: Biology
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