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https://www.readbyqxmd.com/read/28930815/variability-in-usual-care-mechanical-ventilation-for-pediatric-acute-respiratory-distress-syndrome-time-for-a-decision-support-protocol
#1
Christopher J L Newth, Katherine A Sward, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Richard Holubkov, Allan Doctor, J Michael Dean, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: Although pediatric intensivists philosophically embrace lung protective ventilation for acute lung injury and acute respiratory distress syndrome, we hypothesized that ventilator management varies. We assessed ventilator management by evaluating changes to ventilator settings in response to blood gases, pulse oximetry, or end-tidal CO2. We also assessed the potential impact that a pediatric mechanical ventilation protocol adapted from National Heart Lung and Blood Institute acute respiratory distress syndrome network protocols could have on reducing variability by comparing actual changes in ventilator settings to those recommended by the protocol...
September 19, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28929899/nutrition-as-a-component-of-dementia-risk-reduction-strategies
#2
Carol E Greenwood, Matthew D Parrott
According to the Alzheimer Society of Canada, within the next generation, Canada will experience a more than doubling of individuals living with dementia and a potentially economically crippling 10-fold increase in costs to Canadians. Up to 50% of cases with dementia can be attributed to seven modifiable, predominantly vascular and/or lifestyle-associated, risk factors. Multi-modal dementia risk reduction strategies, targeting diet, exercise, mental stimulation, and vascular risk monitoring, are likely to be the most successful...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929490/histological-subtypes-of-ovarian-cancer-associated-with-parity-and-breastfeeding-in-the-prospective-million-women-study
#3
Kezia Gaitskell, Jane Green, Kirstin Pirie, Isobel Barnes, Carol Hermon, Gillian K Reeves, Valerie Beral
Ovarian cancer risk is known to be reduced amongst women who have had children, but reported associations with breastfeeding are varied. Few studies have had sufficient power to explore reliably these associations by tumour histotype. In a prospective study of 1.1 million UK women, 8719 developed ovarian cancer during follow-up. Cox regression yielded adjusted relative risks (RRs) overall and by tumour histotype amongst women with different childbearing patterns. Nulliparous women had a 24% greater ovarian cancer risk than women with one child, with significant heterogeneity by histotype (p=0...
September 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28929291/evaluation-of-an-advance-care-planning-web-based-resource-applicability-for-cancer-treatment-patients
#4
Martha A Cresswell, Carole A Robinson, Gillian Fyles, Joan L Bottorff, Rebecca Sudore
PURPOSE: The purpose of this study was to explore the acceptability, applicability, and understandability of a promising advance care planning (ACP) web-based resource for use with oncology patients, and determine whether revisions to the website would be necessary before implementation into oncology care. The resource is called PREPARE ( www.prepareforyourcare.org ) and it had not been tested for use within oncology, but had previously been shown to influence the readiness of older, community-dwelling adults to engage in ACP behaviors...
September 19, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28929082/endocrine-therapy-of-estrogen-receptor-positive-breast-cancer-cells-early-differential-effects-on-stem-cell-markers
#5
Euphemia Y Leung, Marjan E Askarian-Amiri, Debina Sarkar, Carole Ferraro-Peyret, Wayne R Joseph, Graeme J Finlay, Bruce C Baguley
INTRODUCTION: Endocrine therapy of breast cancer, which either deprives cancer tissue of estrogen or prevents estrogen pathway signaling, is the most common treatment after surgery and radiotherapy. We have previously shown for the estrogen-responsive MCF-7 cell line that exposure to tamoxifen, or deprivation of estrogen, leads initially to inhibition of cell proliferation, followed after several months by the emergence of resistant sub-lines that are phenotypically different from the parental line...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28928963/recent-advances-in-understanding-the-roles-of-whole-genome-duplications-in-evolution
#6
REVIEW
Carol MacKintosh, David E K Ferrier
Ancient whole-genome duplications (WGDs)- paleopolyploidy events-are key to solving Darwin's 'abominable mystery' of how flowering plants evolved and radiated into a rich variety of species. The vertebrates also emerged from their invertebrate ancestors via two WGDs, and genomes of diverse gymnosperm trees, unicellular eukaryotes, invertebrates, fishes, amphibians and even a rodent carry evidence of lineage-specific WGDs. Modern polyploidy is common in eukaryotes, and it can be induced, enabling mechanisms and short-term cost-benefit assessments of polyploidy to be studied experimentally...
2017: F1000Research
https://www.readbyqxmd.com/read/28928140/selenoprotein-t-is-a-novel-ost-subunit-that-regulates-upr-signaling-and-hormone-secretion
#7
Abdallah Hamieh, Dorthe Cartier, Houssni Abid, André Calas, Carole Burel, Christine Bucharles, Cedric Jehan, Luca Grumolato, Marc Landry, Patrice Lerouge, Youssef Anouar, Isabelle Lihrmann
Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production in endocrine cells. Using immunofluorescence and TEM immunogold approaches, we find that SelT is expressed at the endoplasmic reticulum membrane in all hormone-producing pituitary cell types. SelT knockdown in corticotrope cells promotes unfolded protein response (UPR) and ER stress and lowers endoplasmic reticulum-associated protein degradation (ERAD) and hormone production...
September 19, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28927750/the-challenge-of-the-application-of-omics-technologies-in-chemicals-risk-assessment-background-and-outlook
#8
Ursula G Sauer, Lize Deferme, Laura Gribaldo, Jörg Hackermüller, Tewes Tralau, Ben van Ravenzwaay, Carole Yauk, Alan Poole, Weida Tong, Timothy W Gant
This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that 'omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard assessment. While they are used within weight-of-evidence approaches to investigate substances' modes-of-action, consistent approaches for the generation, processing and interpretation of 'omics data are not applied. To date, no 'omics technology has been standardised or validated. Best practices for performing 'omics studies for regulatory purposes (e...
September 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28927533/from-sperm-to-offspring-assessing-the-heritable-genetic-consequences-of-paternal-smoking-and-potential-public-health-impacts
#9
REVIEW
Marc A Beal, Carole L Yauk, Francesco Marchetti
Individuals who smoke generally do so with the knowledge of potential consequences to their own health. What is rarely considered are the effects of smoking on their future children. The objective of this work was to review the scientific literature on the effects of paternal smoking on sperm and assess the consequences to offspring. A literature search identified over 200 studies with relevant data in humans and animal models. The available data were reviewed to assess the weight of evidence that tobacco smoke is a human germ cell mutagen and estimate effect sizes...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28926636/the-expected-and-unexpected-benefits-of-dispensing-the-exact-number-of-pills
#10
Carole Treibich, Sabine Lescher, Luis Sagaon-Teyssier, Bruno Ventelou
BACKGROUND: From November 2014 to November 2015, an experiment in French community pharmacies replaced traditional pre-packed boxes by per-unit dispensing of pills in the exact numbers prescribed, for 14 antibiotics. METHODS: A cluster randomised control trial was carried out in 100 pharmacies. 75 pharmacies counted out the medication by units (experimental group), the other 25 providing the treatment in the existing pharmaceutical company boxes (control group)...
2017: PloS One
https://www.readbyqxmd.com/read/28926488/potential-acceptability-of-a-pediatric-ventilator-management-computer-protocol
#11
Katherine A Sward, Christopher J L Newth, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Allan Doctor, J Michael Dean, Richard Holobkov, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: To examine issues regarding the granularity (size/scale) and potential acceptability of recommendations in a ventilator management protocol for children with pediatric acute respiratory distress syndrome. DESIGN: Survey/questionnaire. SETTING: The eight PICUs in the Collaborative Pediatric Critical Care Research Network. PARTICIPANTS: One hundred twenty-two physicians (attendings and fellows). INTERVENTIONS: None...
September 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28926416/blood-pressure-variability-and-cognitive-function-among-older-african-americans-introducing-a-new-blood-pressure-variability-measure
#12
Siny Tsang, Scott A Sperling, Moon Ho Park, Ira M Helenius, Ishan C Williams, Carol Manning
BACKGROUND: Although blood pressure (BP) variability has been reported to be associated with cognitive impairment, whether this relationship affects African Americans has been unclear. We sought correlations between systolic and diastolic BP variability and cognitive function in community-dwelling older African Americans, and introduced a new BP variability measure that can be applied to BP data collected in clinical practice. METHODS: We assessed cognitive function in 94 cognitively normal older African Americans using the Mini-Mental State Examination (MMSE) and the Computer Assessment of Mild Cognitive Impairment (CAMCI)...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28926414/exploration-of-quantitative-sensory-testing-in-latent-trigger-points-and-referred-pain-areas
#13
Silvia Ambite-Quesada, José L Arías-Buría, Carol A Courtney, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate somato-sensory nerve fibre function by applying different quantitative sensory testing including thermal, mechanical and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area. METHODS: A total of 20 subjects with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contra-lateral mirror areas...
September 15, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28926401/the-missing-27
#14
Adam Akullian, Anna Bershteyn, Britta Jewell, Maya Petersen, Carol S Camlin
No abstract text is available yet for this article.
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28926304/substance-use-in-youth-with-borderline-personality-disorder
#15
Franco Scalzo, Carol A Hulbert, Jennifer K Betts, Sue M Cotton, Andrew M Chanen
Co-occurring substance misuse and borderline personality disorder (BPD) in adults is associated with more severe dysfunction and poorer prognosis than BPD alone. However, it is unknown to what extent substance use in youth with BPD is normative for this age group or pathological. This study compared substance use in 117 help-seeking youth (aged 15-25 years) with their first presentation for treatment of BPD, with an epidemiological general population sample and with healthy, age- and gender-matched controls...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28926185/abstracts
#16
Robin S Cronin, Carol Chelimo, Edwin A Mitchell, Kara Okesene-Gafa, John Thompson, Rennae S Taylor, B Lynne Hutchison, Lesley M E McCowan
No abstract text is available yet for this article.
September 19, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28925348/identification-with-terrorist-attack-victims-association-with-television-viewing-and-prior-life-threat
#17
Holly B Herberman Mash, Carol S Fullerton, K Nikki Benevides, Robert J Ursano
OBJECTIVE: A series of sniper attacks in the Washington, DC, area left 10 people dead and 3 wounded. We developed and tested a model that examined the unique and interdependent relationships of sniper-related television viewing, prior life-threatening events, and parental status to identification with attack victims. METHODS: Participants were 1238 residents of the DC area (aged 18-90 years, mean=41.7 years; 51% female; 68% white) who completed an online survey that assessed identification with sniper attack victims, amount of television viewing, and prior life-threatening events...
September 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28925342/a-study-of-selected-ethnic-affiliations-in-the-development-of-post-traumatic-stress-disorder-and-other-psychopathology-after-a-terrorist-bombing-in-nairobi-kenya
#18
Carol S North, Tatiana Dvorkina, Samuel Thielman, Betty Pfefferbaum, Pushpa Narayanan, David E Pollio
OBJECTIVES: Despite the frequency of disasters in Africa, almost nothing is known about ethnic affiliations in relation to psychopathology after such incidents. This study examined the mental health outcomes of members of 7 major ethnic groups exposed to the 1998 terrorist bombing of the US Embassy in Nairobi, Kenya. METHODS: Approximately 8 to 10 months after the disaster, 229 civilian employees, 99 locally engaged staff workers of the US State Department and the US Agency for International Development, and 64 workers of the Kenyan Red Cross Society (total N=392) were assessed with the Diagnostic Interview Schedule for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)...
September 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28925085/-18-f-fdg-pet-ct-as-adjunctive-diagnostic-modalities-in-canine-fever-of-unknown-origin
#19
Megan Grobman, Leah Cohn, Stephanie Knapp, Jeffrey N Bryan, Carol Reinero
Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) F-FDG-PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe (18) F-FDG-PET or (18) F-FDG-PET/CT findings in a group of dogs with fever of unknown origin...
September 18, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28923966/amazon-plant-diversity-revealed-by-a-taxonomically-verified-species-list
#20
Domingos Cardoso, Tiina Särkinen, Sara Alexander, André M Amorim, Volker Bittrich, Marcela Celis, Douglas C Daly, Pedro Fiaschi, Vicki A Funk, Leandro L Giacomin, Renato Goldenberg, Gustavo Heiden, João Iganci, Carol L Kelloff, Sandra Knapp, Haroldo Cavalcante de Lima, Anderson F P Machado, Rubens Manoel Dos Santos, Renato Mello-Silva, Fabián A Michelangeli, John Mitchell, Peter Moonlight, Pedro Luís Rodrigues de Moraes, Scott A Mori, Teonildes Sacramento Nunes, Terry D Pennington, José Rubens Pirani, Ghillean T Prance, Luciano Paganucci de Queiroz, Alessandro Rapini, Ricarda Riina, Carlos Alberto Vargas Rincon, Nádia Roque, Gustavo Shimizu, Marcos Sobral, João Renato Stehmann, Warren D Stevens, Charlotte M Taylor, Marcelo Trovó, Cássio van den Berg, Henk van der Werff, Pedro Lage Viana, Charles E Zartman, Rafaela Campostrini Forzza
Recent debates on the number of plant species in the vast lowland rain forests of the Amazon have been based largely on model estimates, neglecting published checklists based on verified voucher data. Here we collate taxonomically verified checklists to present a list of seed plant species from lowland Amazon rain forests. Our list comprises 14,003 species, of which 6,727 are trees. These figures are similar to estimates derived from nonparametric ecological models, but they contrast strongly with predictions of much higher tree diversity derived from parametric models...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
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