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https://www.readbyqxmd.com/read/29791486/involvement-of-the-renin-angiotensin-system-in-the-progression-of-severe-hand-foot-and-mouth-disease
#1
Chao Zhang, Shuaiyin Chen, Guangyuan Zhou, Yuefei Jin, Rongguang Zhang, Haiyan Yang, Yuanlin Xi, Jingchao Ren, Guangcai Duan
BACKGROUND: Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD...
2018: PloS One
https://www.readbyqxmd.com/read/29764555/-role-of-noninvasive-mechanical-ventilation-in-patients-with-severe-avian-influenza-a-h7n9-complicated-with-acute-respiratory-distress-syndrome
#2
Haili Luo, Shaohong Wang, Feng Shen, Tongmei Yuan, Xianguo Pan, Jingtao Liu, Ling Yao, Juncheng Wu, Xuemei Long
Human infection with avian influenza A (H7N9) is an acute contagious respiratory disease. Acute respiratory distress syndrome (ARDS) is a common complication in patients with severe avian influenza A (H7N9), for whom mechanical ventilation (MV) is an important supportive method. A patient, suffered from severe avian influenza A (H7N9) and complicated with ARDS, was admitted to the Second Affiliated Hospital of Guizhou Medical University in January 2017. With very intensive care for oxygenation, respiration and consciousness, and monitoring, she was successfully cured by comprehensive managements, among which noninvasive mechanical ventilation (NIV) was the major respiratory support method...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764421/computational-analysis-of-the-receptor-binding-specificity-of-novel-influenza-a-h7n9-viruses
#3
Xinrui Zhou, Jie Zheng, Fransiskus Xaverius Ivan, Rui Yin, Shoba Ranganathan, Vincent T K Chow, Chee-Keong Kwoh
BACKGROUND: Influenza viruses are undergoing continuous and rapid evolution. The fatal influenza A/H7N9 has drawn attention since the first wave of infections in March 2013, and raised more grave concerns with its increased potential to spread among humans. Experimental studies have revealed several host and virulence markers, indicating differential host binding preferences which can help estimate the potential of causing a pandemic. Here we systematically investigate the sequence pattern and structural characteristics of novel influenza A/H7N9 using computational approaches...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29760700/bacillus-calmette-gu%C3%A3-rin-induced-trained-immunity-is-not-protective-for-experimental-influenza-a-anhui-1-2013-h7n9-infection-in-mice
#4
Charlotte L C J de Bree, Renoud J Marijnissen, Junda M Kel, Sietske K Rosendahl Huber, Peter Aaby, Christine Stabell Benn, Marcel V W Wijnands, Dimitri A Diavatopoulos, Reinout van Crevel, Leo A B Joosten, Mihai G Netea, John Dulos
Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adaptations to humans in the viral genome could potentially lead to an influenza pandemic, which may have severe consequences due to the absence of pre-existent immunity to this strain at population level. Currently there is no influenza A (H7N9) vaccine available. Therefore, in case of a pandemic outbreak, alternative preventive approaches are needed, ideally even independent of the type of influenza virus outbreak...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29748572/publisher-correction-sudden-emergence-of-human-infections-with-h7n9-avian-influenza-a-virus-in-hubei-province-central-china
#5
Jiafa Liu, Junqiang Xu, Linlin Liu, Xiaoman Wei, Yi Song, Bin Fang, Xiao Yu, Xiang Li, Guojun Ye, Yingying Du, Mingyue Chen, Weifeng Shi, Di Liu, Edward C Holmes, Jie Cui
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743603/unexpected-infection-outcomes-of-china-origin-h7n9-low-pathogenicity-avian-influenza-virus-in-turkeys
#6
Marek J Slomka, Amanda H Seekings, Sahar Mahmood, Saumya Thomas, Anita Puranik, Samantha Watson, Alexander M P Byrne, Daniel Hicks, Alejandro Nunez, Ian H Brown, Sharon M Brookes
The China-origin H7N9 low pathogenicity avian influenza virus (LPAIV) emerged as a zoonotic threat in 2013 where it continues to circulate in live poultry markets. Absence of overt clinical signs in poultry is a typical LPAIV infection outcome, and has contributed to its insidious maintenance in China. This study is the first description of H7N9 LPAIV (A/Anhui/1/13) infection in turkeys, with efficient transmission to two additional rounds of introduced contact turkeys which all became infected during cohousing...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738825/the-fifth-influenza-a-h7n9-epidemic-a-family-cluster-of-infection-in-suzhou-city-of-china-2016
#7
Jiajia Wang, Nan Su, Zefeng Dong, Cheng Liu, Pengwei Cui, Jian-An Huang, Cheng Chen, Yehan Zhu, Liling Chen
OBJECTIVE: Influenza A(H7N9) virus is known for its high pathogenicity in human. A family cluster of influenza A(H7N9) virus infection was identified in Suzhou, China. This study aimed to investigate the possibility of human-to-human transmission of the virus and examine the virologic features of this family cluster. METHODS: The clinical and epidemiologic data of two patients in the family cluster of influenza A(H7N9) virus infection were collected. Viral RNA in samples derived from the two patients, their close contacts, and the environments with likely influenza A(H7N9) virus transmission were tested by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay...
May 5, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29737282/emerging-pathogens-influenza-h7n9
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/29734613/independent-and-interactive-effects-of-ambient-temperature-and-absolute-humidity-on-the-risks-of-avian-influenza-a-h7n9-infection-in-china
#9
Tao Liu, Min Kang, Bing Zhang, Jianpeng Xiao, Hualiang Lin, Yongqian Zhao, Zhao Huang, Xiaojie Wang, Yonghui Zhang, Jianfeng He, Wenjun Ma
The emergence of avian influenza A(H7N9) virus poses a pandemic threat to human beings. It was proposed that meteorological factors might be important environmental factors favoring the occurrence of H7N9 infection, but evidence is still inadequate. In this study, we aimed to investigate the independent and interactive effects of ambient temperature (TM) and absolute humidity (AH) on H7N9 infection risks in China. The individual information of all reported H7N9 cases and daily meteorological data in five provinces/municipality (Zhejiang, Jiangsu, Shanghai, Fujian, and Guangdong) in China during 2013-2016 were collected...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29732752/avian-influenza-viruses-aivs-h9n2-are-in-the-course-of-reassorting-into-novel-aivs
#10
Hui-Ping Chang, Li Peng, Liang Chen, Lu-Fang Jiang, Zhi-Jie Zhang, Cheng-Long Xiong, Gen-Ming Zhao, Yue Chen, Qing-Wu Jiang
In 2013, two episodes of influenza emerged in China and caused worldwide concern. A new H7N9 avian influenza virus (AIV) first appeared in China on February 19, 2013. By August 31, 2013, the virus had spread to ten provinces and two metropolitan cities. Of 134 patients with H7N9 influenza, 45 died. From then on, epidemics emerged sporadically in China and resulted in several victims. On November 30, 2013, a 73-year-old woman presented with an influenza-like illness. She developed multiple organ failure and died 9 d after the onset of disease...
May 2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29729298/development-and-evaluation-of-a-real-time-rt-pcr-assay-for-detection-of-a-novel-avian-influenza-a-h5n6-virus
#11
Rusheng Zhang, Dong Yao, Jingfang Chen, Wen Ye, Xinhua Ou, Tianmu Chen, Biancheng Sun
As of Aug 25, 2017, 17 incidences of human infection and 6 deaths due to the novel H5N6 virus have been reported in China. Genetic analysis of the viral genome revealed that this reassortant virus is highly pathogenic to poultry, and that the virus has a risk of transmission to humans. Accordingly, the development of a rapid, sensitive, and specific molecular diagnostic assay is critical for public health. In this study, a real-time reverse-transcription PCR (RT-PCR) assay was developed to specifically detect the novel H5N6 virus, with primer pairs targeting the hemagglutinin and neuraminidase gene sequences of this virus...
May 2, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29709980/on-case-fatality-rate-h7n9-influenza-resurgence-in-china-in-2017
#12
Hiroshi Yoshikura
No abstract text is available yet for this article.
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29706970/h7n9-avian-influenza-virus-is-efficiently-transmissible-and-induces-an-antibody-response-in-chickens
#13
Peirong Jiao, Yafen Song, Jianni Huang, Chengwei Xiang, Jin Cui, Siyu Wu, Nannan Qu, Nianchen Wang, Guowen Ouyang, Ming Liao
H7N9 viruses pose a threat to human health and they are no less harmful to the poultry industry than the H5N1 avian influenza viruses. However, the pathogenesis, transmissibility, and the host immune response of the H7N9 virus in chickens and mice remain unclear. In this study, we found that H7N9 viruses replicated in multiple organs of the chicken and viral shedding persisted up to 30 days postinoculation (DPI). The viruses were efficiently transmitted between chickens through direct contact. Notably, chickens infected with H7N9 had high antibody levels throughout the entire observation period and their antibody response lasted for 30 DPI...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29691394/replication-and-pathogenic-potential-of-influenza-a-virus-subtypes-h3-h7-and-h15-from-free-range-ducks-in-bangladesh-in-mammals
#14
Rabeh El-Shesheny, Mohammed M Feeroz, Scott Krauss, Peter Vogel, Pamela McKenzie, Richard J Webby, Robert G Webster
Surveillance of wild aquatic birds and free-range domestic ducks in the Tanguar Haor wetlands in Bangladesh has identified influenza virus subtypes H3N6, H7N1, H7N5, H7N9, and H15N9. Molecular characterization of these viruses indicates their contribution to the genesis of new genotypes of H5N1 influenza viruses from clade 2.3.2.1a that are dominant in poultry markets in Bangladesh as well as to the genesis of the highly pathogenic H5N8 virus currently causing disease outbreaks in domestic poultry in Europe and the Middle East...
April 25, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29688498/dynamic-variation-and-reversion-in-the-signature-amino-acids-of-h7n9-virus-during-human-infection
#15
Xiaohui Zou, Qiang Guo, Wei Zhang, Hui Chen, Wei Bai, Binghuai Lu, Wang Zhang, Yanyan Fan, Chao Liu, Yeming Wang, Fei Zhou, Bin Cao
Background: Signature amino acids of H7N9 influenza virus play critical roles in human adaption and pathogenesis, but their dynamic variation is unknown during disease development. Methods: We sequentially collected respiratory samples from H7N9 patients at different timepoints and applied next-generation sequencing (NGS) to the whole genome of the H7N9 virus to investigate the variation at signature sites. Results: A total of 11 patients were involved and from whom 29 samples were successfully sequenced, including samples from multiple timepoints in 9 patients...
April 24, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29681998/global-dynamics-of-an-avian-influenza-a-h7n9-epidemic-model-with-latent-period-and-nonlinear-recovery-rate
#16
Rui Mu, Youping Yang
An SEIR type of compartmental model with nonlinear incidence and recovery rates was formulated to study the combined impacts of psychological effect and available resources of public health system especially the number of hospital beds on the transmission and control of A(H7N9) virus. Global stability of the disease-free and endemic equilibria is determined by the basic reproduction number as a threshold parameter and is obtained by constructing Lyapunov function and second additive compound matrix. The results obtained reveal that psychological effect and available resources do not change the stability of the steady states but can indeed diminish the peak and the final sizes of the infected...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29670587/influenza-viral-vectors-expressing-two-kinds-of-ha-proteins-as-bivalent-vaccine-against-highly-pathogenic-avian-influenza-viruses-of-clade-2-3-4-4-h5-and-h7n9
#17
Jinping Li, Guangyu Hou, Yan Wang, Suchun Wang, Cheng Peng, Xiaohui Yu, Wenming Jiang
The H5 and H7N9 subtypes of highly pathogenic avian influenza viruses (HPAIVs) in China pose a serious challenge to public health and the poultry industry. In this study, a replication competent recombinant influenza A virus of the Í5N1 subtype expressing the H7 HA1 protein from a tri-cistronic NS segment was constructed. A heterologous dimerization domain was used to combine with the truncated NS1 protein of 73 amino acids to increase protein stability. H7 HA1, nuclear export protein coding region, and the truncated NS1 were fused in-frame into a single open reading frame via 2A self-cleaving peptides...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29669294/a-gene-constellation-in-avian-influenza-a-h7n9-viruses-may-have-facilitated-the-fifth-wave-outbreak-in-china
#18
Wenfei Zhu, Jie Dong, Ye Zhang, Lei Yang, Xiyan Li, Tao Chen, Xiang Zhao, Hejiang Wei, Hong Bo, Xiaoxu Zeng, Weijuan Huang, Zi Li, Jing Tang, Jianfang Zhou, Rongbao Gao, Li Xin, Jing Yang, Shumei Zou, Wenbing Chen, Jia Liu, Yuelong Shu, Dayan Wang
The 2016-2017 epidemic of influenza A (H7N9) virus in China prompted concern that a genetic change may underlie increased virulence. Based on an evolutionary analysis of H7N9 viruses from all five outbreak waves, we find that additional subclades of the H7 and N9 genes have emerged. Our analysis indicates that H7N9 viruses inherited NP genes from co-circulating H7N9 instead of H9N2 viruses. Genotypic diversity among H7N9 viruses increased following wave I, peaked during wave III, and rapidly deceased thereafter with minimal diversity in wave V, suggesting that the viruses entered a relatively stable evolutionary stage...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29648602/factors-associated-with-prolonged-viral-shedding-in-patients-with-avian-influenza-a-h7n9-virus-infection
#19
Yeming Wang, Qiang Guo, Zheng Yan, Daming Zhou, Wei Zhang, Shujun Zhou, Yu-Ping Li, Jing Yuan, Timothy M Uyeki, Xinghua Shen, Wenjuan Wu, Hui Zhao, Yun-Fu Wu, Jia Shang, Zhengguang He, Yi Yang, Hongsheng Zhao, Yongqing Hong, Zehua Zhang, Min Wu, Tiemin Wei, Xilong Deng, Yijun Deng, Li-Hua Cai, Weihua Lu, Hongmei Shu, Lin Zhang, Hong Luo, Y Ing Zhou, Heng Weng, Keyi Song, Li Yao, Mingguang Jiang, Boliang Zhao, Ruibin Chi, Boqi Guo, Lin Fu, Long Yu, Haiyan Min, Pu Chen, Shuifang Chen, Liang Hong, Wei Mao, Xiaoping Huang, Lijun Gu, Hui Li, Chen Wang, Bin Cao
Background: Data are limited on the impact of neuraminidase inhibitor (NAI) treatment on avian influenza A(H7N9) virus RNA shedding. Methods: In this multicenter, retrospective study, data were collected from adults hospitalized with A(H7N9) infection during 2013-2017 in China. We compared clinical features and A(H7N9) shedding among patients with different NAI doses and combination therapies and evaluated factors associated with A(H7N9) shedding, using Cox proportional hazards regression...
April 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29628293/social-media-and-outbreaks-of-emerging-infectious-diseases-a-systematic-review-of-literature
#20
REVIEW
Lu Tang, Bijie Bie, Sung-Eun Park, Degui Zhi
BACKGROUND: The public often turn to social media for information during emerging infectious diseases (EIDs) outbreaks. This study identified the major approaches and assessed the rigors in published research articles on EIDs and social media. METHODS: We searched 5 databases for published journal articles on EIDs and social media. We then evaluated these articles in terms of EIDs studied, social media examined, theoretical frameworks, methodologic approaches, and research findings...
April 5, 2018: American Journal of Infection Control
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