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https://www.readbyqxmd.com/read/28739603/novel-in-vitro-booster-vaccination-to-rapidly-generate-antigen-specific-human-monoclonal-antibodies
#1
Irene Sanjuan Nandin, Carol Fong, Cecilia Deantonio, Juan A Torreno-Pina, Simone Pecetta, Paula Maldonado, Francesca Gasparrini, Jose Ordovas-Montanes, Samuel W Kazer, Svend Kjaer, Daryl W Borley, Usha Nair, Julia A Coleman, Daniel Lingwood, Alex K Shalek, Eric Meffre, Pascal Poignard, Dennis R Burton, Facundo D Batista
Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation of B cells into plasma cells, and robust antibody secretion after a few days of culture. We validated this strategy using cells from healthy donors to retrieve human antibodies against tetanus toxoid and influenza hemagglutinin (HA) from H1N1 and newly emergent subtypes such as H5N1 and H7N9...
July 24, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28734805/c-reactive-protein-mediating-immunopathological-lesions-a-potential-treatment-option-for-severe-influenza-a-diseases
#2
Rongbao Gao, Lijie Wang, Tian Bai, Ye Zhang, Hong Bo, Yuelong Shu
Severe influenza diseases with high mortality have been frequently reported, especially in those patients infected with avian influenza A (H5N1, H7N9 or H10N8) or during a pandemic. Respiratory distress, which is attributed to alveolar damage associated with immunopathological lesions, is the most common cause of death. There is a wealth of information on pathogenesis or treatment options. In this study, we showed that high levels of C-reactive protein (CRP) were induced and correlated with complement activation in patients infected with severe influenza A (H5N1, H7N9 or H10N8), and higher levels were induced in fatal patients than in survivors...
July 13, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28734617/epidemiology-evolution-and-pathogenesis-of-h7n9-influenza-viruses-in-five-epidemic-waves-since-2013-in-china
#3
REVIEW
Shuo Su, Min Gu, Di Liu, Jie Cui, George F Gao, Jiyong Zhou, Xiufan Liu
H7N9 influenza viruses were first isolated in 2013 and continue to cause human infections. H7N9 infections represent an ongoing public health threat that has resulted in 1344 cases with 511 deaths as of April 9, 2017. This highlights the continued threat posed by the current poultry trade and live poultry market system in China. Until now, there have been five H7N9 influenza epidemic waves in China; however, the steep increase in the number of humans infected with H7N9 viruses observed in the fifth wave, beginning in October 2016, the spread into western provinces, and the emergence of highly pathogenic (HP) H7N9 influenza outbreaks in chickens and infection in humans have caused domestic and international concern...
July 19, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28730524/genetic-characterization-of-novel-reassortant-h5n6-subtype-influenza-viruses-isolated-from-cats-in-eastern-china
#4
Xueliang Cao, Fan Yang, Haibo Wu, Lihua Xu
Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China...
July 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28718801/from-variation-of-influenza-viral-proteins-to-vaccine-development
#5
REVIEW
Wandi Zhu, Chao Wang, Bao-Zhong Wang
Recurrent influenza epidemics and occasional pandemics are one of the most important global public health concerns and are major causes of human morbidity and mortality. Influenza viruses can evolve through antigen drift and shift to overcome the barriers of human immunity, leading to host adaption and transmission. Mechanisms underlying this viral evolution are gradually being elucidated. Vaccination is an effective method for the prevention of influenza virus infection. However, the emergence of novel viruses, including the 2009 pandemic influenza A (H1N1), the avian influenza A virus (H7N9), and the highly pathogenic avian influenza A virus (HPAI H5N1), that have infected human populations frequently in recent years reveals the tremendous challenges to the current influenza vaccine strategy...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28703705/epidemiology-of-human-infections-with-highly-pathogenic-avian-influenza-a-h7n9-virus-in-guangdong-2016-to-2017
#6
Min Kang, Eric H Y Lau, Wenda Guan, Yuwei Yang, Tie Song, Benjamin J Cowling, Jie Wu, Malik Peiris, Jianfeng He, Chris Ka Pun Mok
We describe the epidemiology of highly pathogenic avian influenza (HPAI) A(H7N9) based on poultry market environmental surveillance and laboratory-confirmed human cases (n = 9) in Guangdong, China. We also compare the epidemiology between human cases of high- and low-pathogenic avian influenza A(H7N9) (n = 51) in Guangdong. Case fatality and severity were similar. Touching sick or dead poultry was the most important risk factor for HPAI A(H7N9) infections and should be highlighted for the control of future influenza A(H7N9) epidemics...
July 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28693091/-etiology-characteristics-analysis-of-the-first-input-human-infection-of-avian-influenza-h7n9-in-tianjin
#7
X Y Li, X Y Li, M Kong, W W Xu, L R Guo, M Zou, X Su, X C Dong, P H Zhou
No abstract text is available yet for this article.
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28692316/h7n9-avian-influenza-a-virus-in-china-a-short-report-on-its-circulation-drug-resistant-mutants-and-novel-antiviral-drugs
#8
Juergen A Richt, Li Zejun, Bao Danqi, Liu Qinfang
The first human H7N9 avian influenza virus case was reported in Shanghai in 2013. Shortly thereafter, this virus spread to other regions in China. Molecular analysis indicated that the H7N9 virus is a reassortant virus containing internal genes from the H9N2 virus and previously described mammalian adaption markers, which could allow the virus to adapt efficiently to a mammalian host. Fortunately, there is no evidence of sustained person-to-person spread. Most of the human H7N9 cases have a history of exposure to live poultry markets (LPMs)...
July 10, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28681576/humoral-and-cellular-immunogenicity-induced-by-avian-influenza-a-h7n9-dna-vaccine-in-mice
#9
Eun Jin Choi, Han Sol Lee, Ji Yun Noh, Joon Young Song, Hee Jin Cheong, Ok Sarah Shin, Hyojin Lee, Moonsup Jeong, Woo Joo Kim
BACKGROUND: In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the development of an effective vaccine for preventing and rapidly controlling avian influenza A (H7N9) virus is needed. In this study, we evaluated the immunogenicity of a synthetic DNA vaccine against H7 HA antigens in mice. MATERIALS AND METHODS: The synthetic consensus H7 HA DNA vaccine (25 or 50 μg) was administered to BALB/c mice at 0, 14, and 28 days by intramuscular injection followed by electroporation...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28679958/fc-functional-antibodies-in-humans-with-severe-h7n9-and-seasonal-influenza
#10
Hillary A Vanderven, Lu Liu, Fernanda Ana-Sosa-Batiz, Thi Ho Nguyen, Yanmin Wan, Bruce Wines, P Mark Hogarth, Danielle Tilmanis, Arnold Reynaldi, Matthew S Parsons, Aeron C Hurt, Miles P Davenport, Tom Kotsimbos, Allen C Cheng, Katherine Kedzierska, Xiaoyan Zhang, Jianqing Xu, Stephen J Kent
BACKGROUND: Both seasonal and novel avian influenza viruses can result in severe infections requiring hospitalization. Anti-influenza antibodies (Abs) with Fc-mediated effector functions, such as Ab-dependent cellular cytotoxicity (ADCC), are of growing interest in control of influenza but have not previously been studied during severe human infections. As such, the objective of this study was to examine Fc-mediated Ab functions in humans hospitalized with influenza infection. METHODS: Serum Ab response was studied in subjects hospitalized with either pandemic H7N9 avian influenza virus in China (n = 18) or circulating seasonal influenza viruses in Melbourne, Australia (n = 16)...
July 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28677861/a-clinical-approach-to-the-threat-of-emerging-influenza-viruses-in-the-asia-pacific-region
#11
REVIEW
David S C Hui, Nelson Lee, Paul K S Chan
Seasonal influenza epidemics and periodic pandemics are important causes of morbidity and mortality. Patients with chronic co-morbid illness, those at the extremes of age and pregnant women are at higher risks of complications requiring hospitalization, whereas young adults and obese individuals were also at increased risk during the A(H1N1) pandemic in 2009. Avian influenza A(H5N1) and A(H7N9) viruses have continued to circulate widely in some poultry populations and infect humans sporadically since 1997 and 2013, respectively...
July 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28675634/predictors-for-fatal-human-infections-with-avian-h7n9-influenza-evidence-from-4-epidemic-waves-in-jiangsu-province-eastern-china-2013-2016
#12
Wang Ma, Haodi Huang, Jian Chen, Ke Xu, Qigang Dai, Huiyan Yu, Fei Deng, Xian Qi, Shenjiao Wang, Jie Hong, Changjun Bao, Xiang Huo, Minghao Zhou
Four epidemic waves of human infection with H7N9 have been recorded in China up to 1 June 2016, including in Jiangsu Province. However, few studies have investigated the differences in patients' characteristics among the 4 epidemic waves, and the analyses of factors associated with fatal infection lacked statistical power in previous studies due to limited sample size METHODS: All laboratory-confirmed A(H7N9) patients in Jiangsu province were analysed. Patients' characteristics were compared across 4 waves and between survivors and those who died...
July 4, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28668573/safety-and-immunogenicity-of-an-inactivated-cell-culture-derived-h7n9-influenza-vaccine-in-healthy-adults-a-phase-i-ii-prospective-randomized-open-label-trial
#13
Un-In Wu, Szu-Min Hsieh, Wen-Sen Lee, Ning-Chi Wang, Hsiang-Chi Kung, Tsong-Yih Ou, Fu-Lun Chen, Te-Yu Lin, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: We conducted a phase I/II clinical trial to evaluate the safety and immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 influenza vaccine for pandemic preparedness purposes. METHODS: Between April 7, 2015 and May 27, 2016, healthy adults aged 20-60years were enrolled sequentially in phase I (n=40) and phase II (n=160) from three hospitals in Taiwan and randomized to receive 2 doses of whole-virus H7N9 vaccine (15 or 30μg hemagglutinin antigen (HA) with or without an aluminum hydroxide adjuvant) at 21-day intervals...
June 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28659900/efficacy-of-live-attenuated-h9n2-influenza-vaccine-candidates-containing-ns1-truncations-against-h9n2-avian-influenza-viruses
#14
Sujuan Chen, Yinbiao Zhu, Da Yang, Yang Yang, Shaohua Shi, Tao Qin, Daxin Peng, Xiufan Liu
H9N2 avian influenza virus is a zoonotic agent with a broad host range that can contribute genetic information to H5 or H7N9 subtype viruses, which are significant threats to both humans and birds. Thus, there is a great need for a vaccine to control H9N2 avian influenza. Three mutant viruses of an H9N2 virus A/chicken/Taixing/10/2010 (rTX-NS1-73, rTX-NS1-100, and rTX-NS1-128) were constructed with different NS1 gene truncations and confirmed by western blot analysis. The genetic stability, pathogenicity, transmissibility, and host immune responses toward these mutants were evaluated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28648014/-clinical-efficacy-observation-of-atomization-inhalation-combined-with-oral-administration-of-oseltamivir-in-4-cases-with-h7n9-avian-influenza
#15
Z Li, X Y Fu, X B Fang, J Li, T Chen, L M Qiu, J Cai, W L Wang, Z Q Pan, Y Zhang, J L Zhou
Objective: To investigate the clinical efficacy of atomization inhalation combined with oral administration of oseltamivir in treatment of human infection with H7N9 avian influenza. Methods: To analyze the clinical data of 4 patients hospitalized from Mar 6th 2017 to Apr 12th 2017 with avian influenza(H7N9) infection treated by conventional therapy(oseltamivir, 150 mg, po, Bid) plus with oseltamivir inhalation(75 mg dissolved in 20 ml N. S, Bid) and administered with antibacterial treatment, blood purification and immunomodulators...
June 27, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28637471/enhanced-humoural-and-cellular-immune-responses-to-influenza-h7n9-antigen-ha1-2-fused-with-flagellin-in-chickens
#16
Li Song, Dan Xiong, Maozhi Hu, Xilong Kang, Zhiming Pan, Xinan Jiao
BACKGROUND: Sudden increases in the number of human A (H7N9) cases reported during December and January have been observed in previous years. Most reported infection cases are due to prior exposure to live poultry or potentially contaminated environments. Low pathogenicity of influenza A (H7N9) virus in avian species complicates timely discovery of infected birds. Therefore, there is a pressing need to develop safe and effective anti-H7N9 vaccines for poultry to reduce the risk of human infection and prevent the emergence of novel mutated strains...
June 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28633457/an-ha-stem-antibody-medi8852-prevents-and-controls-disease-and-limits-transmission-of-pandemic-influenza-viruses
#17
C I Paules, S Lakdawala, J M McAuliffe, M Paskel, L Vogel, N L Kallewaard, Q Zhu, K Subbarao
Background: MEDI8852 is a novel MAb which neutralizes both group I and group II influenza A viruses (IAV) in vitro. We evaluated whether MEDI8852 was effective for prophylaxis and therapy against representative group I (H5N1) and group II (H7N9) pandemic IAV in mice and ferrets and could be used to block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control MAb R347 and oseltamivir. Results: MEDI8852 was effective for prophylaxis and treatment of H7N9 and H5N1 infection in mice, with a clear dose-dependent response and treatment with MEDI8852 24, 48 or 72 h post-infection (hpi) was superior to oseltamivir for H5N1...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28624926/limited-awareness-of-animal-influenza-prevention-and-control-among-dai-lue-smallholder-farmers-in-southwest-china
#18
Xiang Zhao, Gareth Davey
Awareness of animal influenza and its prevention and control is important for ensuring livestock health, production and welfare. In China, a country stereotyped as a major source of emerging zoonotic infectious diseases, research on the public understanding of animal influenza is limited to the Han, the main ethnic group. The present qualitative study in Southwest China investigated awareness of animal influenza among the Dai, an ethnic minority. The participants (15 men and 10 women, ages 18-83) were smallholder farmers of pigs and poultry in rural areas of Jinghong, Xishuangbanna, Yunnan Province...
June 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28617868/three-mutations-switch-h7n9-influenza-to-human-type-receptor-specificity
#19
Robert P de Vries, Wenjie Peng, Oliver C Grant, Andrew J Thompson, Xueyong Zhu, Kim M Bouwman, Alba T Torrents de la Pena, Marielle J van Breemen, Iresha N Ambepitiya Wickramasinghe, Cornelis A M de Haan, Wenli Yu, Ryan McBride, Rogier W Sanders, Robert J Woods, Monique H Verheije, Ian A Wilson, James C Paulson
The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957 (H2N2) and 1968 (H3N2) human influenza pandemic viruses. While this raised concern that the H7N9 virus was adapting to humans, the mutation was not sufficient to switch the receptor specificity of H7N9, and has not resulted in sustained transmission in humans...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28615930/prevention-of-influenza-a-h7n9-and-bacterial-infections-in-mice-using-intranasal-immunization-with-live-influenza-vaccine-and-the-group-b-streptococcus-recombinant-polypeptides
#20
Yulia A Desheva, Galina F Leontieva, Tatiana A Kramskaya, Tatiana A Smolonogina, Kornelia B Grabovskaya, Galina O Landgraf, Vadim E Karev, Alexander N Suvorov, Larisa G Rudenko
We investigate the protective effect of combined vaccination based on live attenuated influenza vaccine (LAIV) and group B streptococcus (GBS) recombinant polypeptides against potential pandemic H7N9 influenza infection followed by GBS burden. Mice were intranasally immunized using 107 50% egg infectious dose (EID50) of H7N3 LAIV, the mix of the 4 GBS peptides (group B streptococcus vaccine [GBSV]), or combined LAIV + GBSV vaccine. The LAIV raised serum hemagglutination-inhibition antibodies against H7N9 in higher titers than against H7N3...
2017: Virology: Research and Treatment
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