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https://www.readbyqxmd.com/read/28539661/the-pb2-mutation-with-lysine-at-627-enhances-the-pathogenicity-of-avian-influenza-h7n9-virus-which-belongs-to-a-non-zoonotic-lineage
#1
Weixuan Li, Horace Hok Yeung Lee, Run Feng Li, Huachen Maria Zhu, Guan Yi, Joseph Sriyal Malik Peiris, Zi Feng Yang, Chris Ka Pun Mok
A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28537546/biological-characterisation-of-the-emerged-highly-pathogenic-avian-influenza-hpai-a-h7n9-viruses-in-humans-in-mainland-china-2016-to-2017
#2
Wenfei Zhu, Jianfang Zhou, Zi Li, Lei Yang, Xiyan Li, Weijuan Huang, Sumei Zou, Wenbing Chen, Hejiang Wei, Jing Tang, Liqi Liu, Jie Dong, Dayan Wang, Yuelong Shu
With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype...
May 11, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28532182/tackling-a-novel-lethal-virus-a-focus-on-h7n9-vaccine-development
#3
Irina Isakova-Sivak, Larisa Rudenko
Avian-origin H7N9 influenza viruses first detected in humans in China in 2013 continue to cause severe human infections with a mortality rate close to 40%. These viruses are acknowledged as the subtype most likely to cause the next influenza pandemic. Areas covered: Here we review published data on the development of H7N9 influenza vaccine candidates and their evaluation in preclinical and clinical trials identified on PubMed database with the term 'H7N9 influenza vaccine'. In addition, a search with the same term was done on ClinicalTrials...
May 22, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28524040/-a-case-of-the-severe-human-infection-by-avian-influenza-h7n9-was-rescued-successfully-by-the-sepsis-bundle
#4
Shaohong Wang, Jintao Liu, Haili Luo, Xianguo Pan, Tongmei Yuan, Xuemei Long
One confirmed diagnosis case of severe human infection by avian influenza H7N9 admitted to intensive care unit (ICU) of the Second Affiliated Hospital of Guizhou Medical University on January 12th, 2017 was reported. The patient was treated with the sepsis bundle, and recovered finally, including a series of comprehensive treatments, such as respiratory support, circulation support, antiviral, anti-inflammation, immunization enhancement, critical nursing, fluid management, nutritional support and treatment of complications...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28521760/avian-influenza-a-h7n9-risk-perception-information-trust-and-adoption-of-protective-behaviours-among-poultry-farmers-in-jiangsu-province-china
#5
Bin Cui, Qiuyan Liao, Wendy Wing Tak Lam, Zong Ping Liu, Richard Fielding
BACKGROUND: Poultry farmers are at high-risk from avian influenza A/H7N9 infection due to sustained occupational exposures to live poultry. This study examined factors associated with poultry farmers' adoption of personal protective behaviours (PPBs) based on Protection Motivation Theory (PMT). METHODS: Totally, 297 poultry farmers in three cities of Jiangsu Province, China were interviewed during November 2013-January 2014. Data on PMT constructs, perceived trustworthiness of A/H7N9 information from mass media (formal sources), friends and family (informal sources), intention to adopt and actual adoption of PPBs and respondents' demographics were collected...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28521528/prevention-and-control-of-emergent-infectious-disease-with-high-specific-antigen-sensor
#6
Hongzhe Zhang, Shanshan Zhang, Nan Liu
This study aims to evaluate the application of a new type of high specificity antigen sensor in detecting the viruses in sudden infectious diseases. Influenza A (H1N1) virus immunosensor was used for the respective determination of the six kinds of antigens of H1N1, H3N2 viral protein, HA protein of H7N9, influenza B virus, adenovirus, and EV71 virus of same dilution degree on the Screen Printed Carbon Electrode (SPCE), so as to test the specificity of the detection method. In addition, various batches of chick embryo allantoic saliva dilution simulation samples were also detected on their recovery (accuracy), repeatability (precision), and stability...
May 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28510725/ifitm3-tlr3-and-cd55-genes-snps-and-cumulative-ge-netic-risks-for-severe-outcomes-in-chinese-patients-with-h7n9-h1n1pdm09-influenza
#7
Nelson Lee, Bin Cao, Changwen Ke, Hongzhou Lu, Yunwen Hu, Ht Claudia Tam, Cw Ronald Ma, Dawei Guan, Zhaoqin Zhu, Hui Li, Lin Mulei, Rity Yk Wong, Irene Mh Yung, Tin-Nok Hung, Kirsty Kwok, Peter Horby, Sc David Hui, Cw Martin Chan, Ks Paul Chan
Background: We examined associations between SNPs (single-nucleotide-polymorphisms) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese patients. Methods: A multicenter-study was conducted on 275 adult cases of prospectively-diagnosed H7N9 and H1N1pdm09 infections. Host DNA was extracted from diagnostic respiratory samples; IFITM3 rs12252, TLR3 rs5743313, CD55 rs2564978, and TLR4 rs4986790/4986791 were targeted for genotyping by Sanger-sequencing...
May 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28500340/both-haemagglutinin-specific-antibody-and-t-cell-responses-induced-by-a-chimpanzee-adenoviral-vaccine-confer-protection-against-influenza-h7n9-viral-challenge
#8
Xiang Wang, Weihui Fu, Songhua Yuan, Xi Yang, Yufeng Song, Lulu Liu, Yudan Chi, Tao Cheng, Man Xing, Yan Zhang, Chao Zhang, Yong Yang, Caihong Zhu, Xiaoyan Zhang, Sidong Xiong, Jianqing Xu, Dongming Zhou
Since 2013, the outbreak or sporadic infection of a new reassortant H7N9 influenza virus in China has resulted in hundreds of deaths and thousands of illnesses. An H7N9 vaccine is urgently needed, as a licensed human vaccine against H7N9 influenza is currently not available. Here, we developed a recombinant adenovirus-based vaccine, AdC68-H7HA, by cloning the H7N9 haemagglutinin (HA) gene into the chimpanzee adenoviral vector AdC68. The efficacy of AdC68-H7HA was evaluated in mice as well as guinea pigs. For comparison, an H7N9 DNA vaccine based on HA was also generated and tested in mice and guinea pigs...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28485329/a-suspected-person-to-person-transmission-of-avian-influenza-a-h7n9-case-in-ward
#9
Ze-Hua Zhang, Ling-Sheng Meng, De-Hua Kong, Jun Liu, Si-Zhao Li, Chao Zhou, Juan Sun, Ren-Jie Song, Jin-Ju Wu
No abstract text is available yet for this article.
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28479181/carbohydrate-fatty-acid-monosulphate-esters-are-safe-and-effective-adjuvants-for-humoral-responses
#10
Luuk A Th Hilgers, Peter Paul L I Platenburg, Jeffrey Bajramovic, Jennifer Veth, Robert Sauerwein, Will Roeffen, Marie Pohl, Geert van Amerongen, Koert J Stittelaar, Johannes F van den Bosch
Carbohydrate fatty acid sulphate esters (CFASEs) formulated in a squalane-in-water emulsion are effective adjuvants for humoral responses to a wide range of antigens in various animal species but rise in body temperature and local reactions albeit mild or minimal hampers application in humans. In rabbits, body temperature increased 1°C one day after intramuscular (IM) injection, which returned to normal during the next day. The effect increased with increasing dose of CFASE but not with the number of injections (up to 5)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28473725/epidemiological-clinical-and-virologic-features-of-two-family-clusters-of-avian-influenza-a-h7n9-virus-infections-in-southeast-china
#11
Jianfeng Xie, Yuwei Weng, Jianming Ou, Lin Zhao, Yanhua Zhang, Jinzhang Wang, Wei Chen, Meng Huang, Wenqiong Xiu, Hongbin Chen, Yongjun Zhang, Binshan Wu, Wenxiang He, Ying Zhu, Libin You, Zhimiao Huang, Canming Zhang, Longtao Hong, Wei Wang, Kuicheng Zheng
This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28468041/-pulmonary-pathology-of-3-cases-infected-with-human-highly-pathogenic-h7n9-avian-influenza
#12
J F Liu
No abstract text is available yet for this article.
May 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28457665/preclinical-and-clinical-demonstration-of-immunogenicity-by-mrna-vaccines-against-h10n8-and-h7n9-influenza-viruses
#13
Kapil Bahl, Joe J Senn, Olga Yuzhakov, Alex Bulychev, Luis A Brito, Kimberly J Hassett, Michael E Laska, Mike Smith, Örn Almarsson, James Thompson, Amilcar Mick Ribeiro, Mike Watson, Tal Zaks, Giuseppe Ciaramella
Recently, the World Health Organization confirmed 120 new human cases of avian H7N9 influenza in China resulting in 37 deaths, highlighting the concern for a potential pandemic and the need for an effective, safe, and high-speed vaccine production platform. Production speed and scale of mRNA-based vaccines make them ideally suited to impede potential pandemic threats. Here we show that lipid nanoparticle (LNP)-formulated, modified mRNA vaccines, encoding hemagglutinin (HA) proteins of H10N8 (A/Jiangxi-Donghu/346/2013) or H7N9 (A/Anhui/1/2013), generated rapid and robust immune responses in mice, ferrets, and nonhuman primates, as measured by hemagglutination inhibition (HAI) and microneutralization (MN) assays...
April 11, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28455520/a-humanized-mouse-model-identifies-key-amino-acids-for-low-immunogenicity-of-h7n9-vaccines
#14
Yamato Wada, Arnone Nithichanon, Eri Nobusawa, Leonard Moise, William D Martin, Norio Yamamoto, Kazutaka Terahara, Haruhisa Hagiwara, Takato Odagiri, Masato Tashiro, Ganjana Lertmemongkolchai, Haruko Takeyama, Anne S De Groot, Manabu Ato, Yoshimasa Takahashi
Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains unknown due to the lack of animal models reproducing the response observed in humans. Here, we utilized a humanized mouse model to recapitulate the low immunogenicity of H7 HA...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28448630/correction-influenza-a-h5n1-and-h7n9-in-china-a-spatial-risk-analysis
#15
Chau Minh Bui, Lauren Gardner, C Raina MacIntyre, Sahotra Sarkar
[This corrects the article DOI: 10.1371/journal.pone.0174980.].
2017: PloS One
https://www.readbyqxmd.com/read/28435679/targeting-the-pro-inflammatory-factor-ccl2-mcp-1-with-bindarit-for-influenza-a-h7n9-treatment
#16
Stefan Wolf, Scott Johnson, Olivia Perwitasari, Suresh Mahalingam, Ralph A Tripp
Influenza A viruses are important human and animal pathogens. Seasonal influenza viruses cause infections every year, and occasionally zoonotic viruses emerge to cause pandemics with significantly higher morbidity and mortality rates. Three cases of laboratory confirmed human infection with avian influenza A (H7N9) virus were reported in 2013, and there have been several cases reported across South East Asia, and recently in North America. Most patients experience severe respiratory illness, with mortality rates approaching 40%...
March 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28424686/mucosal-and-systemic-immune-responses-to-influenza-h7n9-antigen-ha1-2-co-delivered-intranasally-with-flagellin-or-polyethyleneimine-in-mice-and-chickens
#17
Li Song, Dan Xiong, Hongqin Song, Lili Wu, Meihua Zhang, Xilong Kang, Zhiming Pan, Xinan Jiao
Consecutive cases of human infection with H7N9 influenza viruses since 2013 in China have prompted efforts to develop an effective treatment. Subunit vaccines introduced by intranasal administration can block an infection at its primary site; flagellin (fliC) and polyethyleneimine (PEI) have been shown to be potent adjuvants. We previously generated the hemagglutinin (HA)1-2-fliC fusion protein consisting of the globular head domain (HA1-2; amino acids 62-284) of HA fused with Salmonella typhimurium fliC. In the present study, we investigated its effectiveness of both flagellin and PEI as mucosal adjuvants for the H7N9 influenza subunit vaccine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28424051/erratum-to-population-seroprevalence-of-antibody-to-influenza-a-h7n9-virus-guangzhou-china
#18
Yong Ping Lin, Zi Feng Yang, Ying Liang, Zheng Tu Li, Helen S Bond, Huiying Chua, Ya Sha Luo, Yuan Chen, Ting Ting Chen, Wen Da Guan, Jimmy Chun Cheong Lai, Yu Lam Siu, Si Hua Pan, J S Malik Peiris, Benjamin J Cowling, Chris Ka Pun Mok
No abstract text is available yet for this article.
April 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28423682/rip3-deficiency-ameliorates-inflammatory-response-in-mice-infected-with-influenza-h7n9-virus-infection
#19
Yu-Lin Xu, Hai-Lin Tang, Hao-Ran Peng, Ping Zhao, Zhong-Tian Qi, Wen Wang
Influenza H7N9 virus infection causes an acute, highly contagious respiratory illness that triggers cell death of infected cells and airway epithelial destruction. RIP3 is a key regulator of cell death responses to a growing number of viral and microbial agents. This study aimed to investigate the role of RIP3 in inflammation of influenza H7N9 virus infection. Here, RIP3 knock out (RIP3-/-) mice and littermate wild type mice were infected intranasally with influenza H7N9 virus (A/Fujian/S03/2015) to determine the contribution of RIP3 to the inflammatory response of influenza H7N9 virus infection...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421067/c-c-motif-chemokine-ligand-2-ccl2-mediates-acute-lung-injury-induced-by-lethal-influenza-h7n9-virus
#20
Chengcai Lai, Keyu Wang, Zhongpeng Zhao, Liangyan Zhang, Hongjing Gu, Penghui Yang, Xiliang Wang
An avian-origin influenza A (H7N9) virus was a cause for concern in China in the spring of 2013. Most H7N9 infections resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that contributes to morbidity and mortality. In this study, we induced viral ALI by infecting wild-type and CCL2-deficient mice with influenza H7N9 virus. The results suggested a close association between C-C motif chemokine ligand 2 (CCL2) expressions and ALI induced by a lethal H7N9 virus strain (A/Hebei/01/2013)...
2017: Frontiers in Microbiology
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