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https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#1
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27908257/ginkgo-biloba-as-an-alternative-medicine-in-the-treatment-of-anxiety-in-dementia-and-other-psychiatric-disorders
#2
Sandeep Kumar Singh, George E Barreto, Gjumrakch Aliev, Valentina Echeverria
BACKGROUND: Mental disorders are the most common health problems in the worldwide population. Current medicines against these conditions have undesired side effects or limited effectiveness. These disadvantageous pharmacological and therapeutic characteristics provoke a low adherence to treatment in an important percentage of patients with mental disorders. Since ancient times, ethnically different groups have been using plants extracts as medicines for the treatment of mental conditions including dementia, depression and anxiety disorders...
December 1, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27896487/natural-compounds-as-occult-ototoxins-ginkgo-biloba-flavonoids-moderately-damage-lateral-line-hair-cells
#3
Sarah Neveux, Nicole K Smith, Anna Roche, Bruce E Blough, Wimal Pathmasiri, Allison B Coffin
Several drugs, including aminoglycosides and platinum-based chemotherapy agents, are well known for their ototoxic properties. However, FDA-approved drugs are not routinely tested for ototoxicity, so their potential to affect hearing often goes unrecognized. This issue is further compounded for natural products, where there is a lack of FDA oversight and the manufacturer is solely responsible for ensuring the safety of their products. Natural products such as herbal supplements are easily accessible and commonly used in the practice of traditional eastern and alternative medicine...
November 28, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27852128/antagonistic-effects-of-gingko-biloba-and-sophora-japonica-on-cerebral-vasoconstriction-in-response-to-histamine-5-hydroxytryptamine-u46619-and-bradykinin
#4
Ha Thi Thanh Nguyen, Hai Thanh Nguyen, Md Zahorul Islam, Takeshi Obi, Pitchaya Pothinuch, Thanh Van Nguyen, Tuong Manh Nguyen, Cuong Van Dao, Mitsuya Shiraishi, Atsushi Miyamoto
The aim of this study was to evaluate, for the first time, the antagonistic effects of Gingko biloba leaf (GB) and Sophora japonica L. flower bud (SJ) extracts on cerebral vasoconstriction in response to KCl, extracellular Ca[Formula: see text], histamine, 5-hydroxytryptamine (5-HT), 9,11-dideoxy-9[Formula: see text],11[Formula: see text]-methanoepoxy prostaglandin (PG) F[Formula: see text](U46619) and bradykinin (BK), in order to explain their traditional application for diseases associated with cerebral vasospasm...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27659250/a-review-of-three-commonly-used-herbs-which-enhance-memory-and-new-evidences-which-show-their-combination-could-improve-memory-in-young-animals
#5
Fei Hong, Liju Wang, Sharon L Wu, Hong Chai Tang, Maria Sm Wai, David Tai Wai Yew
This review looks into the herbs gingko biloba, polygala tenuifolia, and lycii fructus for their widely studied neuroprotective properties. Effects of the interaction between the herbs are studied by behavior tests to evaluate memory, and examination of signal transduction enzyme, major neurotransmitters, cell death and antioxidation. For 6-month treated mice, behavior showed shorter escape latency in the water maze and faster arrival time in a consolidated memory task. Immunochemistry showed evident increase in superoxide dismutase (SOD) activities in the prefrontal cortex, which implies protection against harmful free radicals during aging...
September 19, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27416687/hyperbaric-oxygen-therapy-in-tinnitus-with-normal-hearing-in-association-with-combined-treatment
#6
Richard Holy, Pavol Prazenica, Eva Stolarikova, Petr Dosel, Petra Fundova, Daniel Kovar, Jaromir Astl
Tinnitus is a phantom perception of sound in the absence of overt acoustic stimulation. The focus of our attention is a combined therapy of tinnitus. In this prospective study (2013-2014) we evaluated the data of normal-hearing patients with tinnitus treated with various treatment modalities. In Group 1 we evaluated the data of 84 patients/124 ears after six weeks of treatment with betahistine dihydrochloride (72 mg). In Group 2, we evaluated the data of 36 patients/ 55 ears unimproved from Group 1 who were then treated for six weeks with hyperbaric oxygen (HBO₂) therapy combined with gingko biloba extract (120 mg)...
May 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/27081765/adverse-effects-of-herbal-or-dietary-supplements-in-g6pd-deficiency-a-systematic-review
#7
Shaun Wen Huey Lee, Nai Ming Lai, Nathorn Chaiyakunapruk, David Weng Kwai Chong
AIM: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals. METHODS: We searched fourteen electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals...
April 15, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27027912/influence-of-some-plant-extracts-on-the-transdermal-absorption-and-penetration-of-marker-penetrants
#8
Faqir Muhammad, June Wiley, Jim E Riviere
CONTEXT: Plant extracts are commonly used in a number of cosmetics and topical pharmaceuticals. The effects on such extracts on the subsequent dermal absorption and penetration of other cosmetic ingredients needs to be evaluated. OBJECTIVE: This study demonstrates the effect of some natural extracts routinely found in cosmetics on the dermal absorption and penetration of marker penetrants. METHODS: Aqueous ethanolic extracts of Gingko biloba, Lavendula angustifolia, Rosmarinus officinale, Mentha piperita, Matricaria recutita, Persea Americana, Avena sativa, Zingiber officinale were prepared...
March 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/26908182/effects-of-gingko-biloba-extract-egb-761-on-vascular-smooth-muscle-cell-calcification-induced-by-%C3%AE-glycerophosphate
#9
En-Gang Li, Jun Tian, Zhong-Hua Xu
OBJECTIVE: To investigate the effects of Gingko biloba extract (EGb 761) on calcification induced by β-glycerophosphate in rat aortic vascular smooth muscle cells. METHODS: Rat aortic vascular smooth muscle cells were cultured with various concentrations of EGb 761 and β-glycerophosphate for 7 days. Calcium content in the cells, alkaline phosphatase activity, cell protein content, NF-κB activation, and reactive oxygen species production were assayed, respectively...
2016: Renal Failure
https://www.readbyqxmd.com/read/26867200/dha-supplementation-alone-or-in-combination-with-other-nutrients-does-not-modulate-cerebral-hemodynamics-or-cognitive-function-in-healthy-older-adults
#10
RANDOMIZED CONTROLLED TRIAL
Philippa A Jackson, Joanne S Forster, J Gordon Bell, James R Dick, Irene Younger, David O Kennedy
A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B₉ and B₁₂) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50-70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial...
February 9, 2016: Nutrients
https://www.readbyqxmd.com/read/26708230/evaluation-of-embryotoxicity-for-major-components-of-herbal-extracts-using-the-chick-embryonic-heart-micromass-and-mouse-d3-embryonic-stem-cell-systems
#11
Omar J Mohammed, Muhammad Liaque Latif, Margaret K Pratten
Herbal remedies are often used during the early stages of pregnancy, being considered 'harmless' and 'natural'. There are insufficient data regarding their potential embryotoxicity. The main components of selected herbs, including 6-gingerol from ginger, Ginkgolide A and Ginkgolide B from gingko biloba and Ginsenoside Rg1 from ginseng, have been investigated using chick embryonic heart micromass and Mouse D3 embryonic stem cells. The potential effects were evaluated via alteration in contractility, cell viability, and cell protein content...
January 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/26563011/efficacy-of-medical-therapy-in-the-prevention-of-residual-dizziness-after-successful-repositioning-maneuvers-for-benign-paroxysmal-positional-vertigo-bppv
#12
RANDOMIZED CONTROLLED TRIAL
B Acar, R M Karasen, Y Buran
OBJECTIVES: The aim of this study was to investigate the efficacy of trimetazidine, betahistine, and ginkgo biloba extract in the treatment of residual dizziness after successful repositioning maneuvers for benign paroxysmal positional vertigo. METHODOLOGY: This was a randomized controlled clinical trial. Complete clinical data were analyzed from 100 patients (27 men and 73 women; mean age 52.16 ± 13.2 years, range 11-80 years) with BPPV who underwent succcessful repositioning maneuvers and then received betahistine, trimetazidine, gingko biloba extract, or no medication (n = 25 for each group) for 1 week...
2015: B-ENT
https://www.readbyqxmd.com/read/26510143/your-questions-about-complementary-medicines-answered-gingko-biloba
#13
Sanne Kreijkamp-Kaspers, Treasure McGuire, Suzanne Bedford, Peter Loadsman, Marie Pirotta, Geraldine Moses, Mieke L van Driel
This is the fourth article in a series providing evidence-based answers to common questions about complementary medicines from consumers and healthcare professionals.
August 2015: Australian Family Physician
https://www.readbyqxmd.com/read/26455874/beneficial-effects-of-egb761-and-vitamin-e-on-haloperidol-induced-vacuous-chewing-movements-in-rats-possible-involvement-of-s100b-mechanisms
#14
COMPARATIVE STUDY
Hui Mei An, Yun Long Tan, Jing Shi, Zhi Ren Wang, Jia Li, Yue Chan Wang, Meng Han Lv, Dong Feng Zhou, Jair C Soares, Thoams R Kosten, Fu De Yang, Xiang Yang Zhang
Tardive dyskinesia (TD) is a serious side effect induced by the long-term administration of typical antipsychotics. The pathophysiology of TD remains unclear, but experimental evidence suggests that neurodegeneration caused by free radicals may play an important role in TD development. S100B is considered a potential biomarker of structural neural and glial damage. This study investigated S100B expression in TD-related brain regions and assessed the effect of antioxidants Gingko biloba leaf extract (EGb761) and vitamin E (VE) on S100B in TD rats...
January 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26417854/pentoxifylline-for-intermittent-claudication
#15
REVIEW
Kareem Salhiyyah, Rachel Forster, Eshan Senanayake, Mohammed Abdel-Hadi, Andrew Booth, Jonathan A Michaels
BACKGROUND: Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility and promoting microcirculatory flow and tissue oxygen concentration. Many studies have evaluated the efficacy of pentoxifylline in treating individuals with PAD, but results of these studies are variable. This is an update of a review first published in 2012...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26330310/the-spatial-distribution-of-fossil-fuel-co2-traced-by-%C3%AE-14-c-in-the-leaves-of-gingko-ginkgo-biloba-l-in-beijing-city-china
#16
Zhenchuan Niu, Weijian Zhou, Xiaoshan Zhang, Sen Wang, Dongxia Zhang, Xuefeng Lu, Peng Cheng, Shugang Wu, Xiaohu Xiong, Hua Du, Yunchong Fu
Atmospheric fossil fuel CO2 (CO2ff ) information is an important reference for local government to formulate energy-saving and emission reduction in China. The CO2ff spatial distribution in Beijing City was traced by Δ(14)C in the leaves of gingko (Ginkgo biloba L.) from late March to September in 2009. The Δ(14)C values were in the range of -35.2 ± 2.8∼15.5 ± 3.2 ‰ (average 3.4 ± 11.8 ‰), with high values found at suburban sites (average 12.8 ± 3.1 ‰) and low values at road sites (average -8...
January 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26188295/peg-based-ultrasound-assisted-enzymatic-extraction-of-polysaccharides-from-ginkgo-biloba-leaves
#17
Lijin Zhang, Shanshan Guo, Maoshan Wang, Lei He
In this study, one kind of environmentally friendly solvents named polyethylene glycol (PEG) was developed for the ultrasound-assisted enzymatic extraction (UAEE) of polysaccharides from Gingko biloba leaves (GBLP). Box-Behnken design (BBD) was used to optimize the UAEE conditions of GBLP. Results showed that the optimal extraction conditions were: a pH of 4.34, an extraction temperature of 51.88 °C and an extraction time of 37.13 min. Under these optimal extraction conditions, the GBLP yield was 7.29±0.21%, which was well in agreement with the value predicted by the mathematical model...
September 2015: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/25878948/a-molecular-docking-study-of-phytochemical-estrogen-mimics-from-dietary-herbal-supplements
#18
Chelsea N Powers, William N Setzer
PURPOSE: The purpose of this study is to use a molecular docking approach to identify potential estrogen mimics or anti-estrogens in phytochemicals found in popular dietary herbal supplements. METHODS: In this study, 568 phytochemicals found in 17 of the most popular herbal supplements sold in the United States were built and docked with two isoforms of the estrogen receptor, ERα and ERβ (a total of 27 different protein crystal structures). RESULTS: The docking results revealed six strongly docking compounds in Echinacea, three from milk thistle (Silybum marianum), three from Gingko biloba, one from Sambucus nigra, none from maca (Lepidium meyenii), five from chaste tree (Vitex agnus-castus), two from fenugreek (Trigonella foenum-graecum), and two from Rhodiola rosea...
2015: In Silico Pharmacology
https://www.readbyqxmd.com/read/25747340/maximizing-clinical-cohort-size-using-free-text-queries
#19
Adi V Gundlapalli, Doug Redd, Bryan Smith Gibson, Marjorie Carter, Chris Korhonen, Jonathan Nebeker, Matthew H Samore, Qing Zeng-Treitler
BACKGROUND: Cohort identification is important in both population health management and research. In this project we sought to assess the use of text queries for cohort identification. Specifically we sought to determine the incremental value of unstructured data queries when added to structured queries for the purpose of patient cohort identification. METHODS: Three cohort identification tasks were evaluated: identification of individuals taking gingko biloba and warfarin simultaneously (Gingko/Warfarin), individuals who were overweight, and individuals with uncontrolled diabetes (UCD)...
May 2015: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/25597699/effect-of-single-dose-ginkgo-biloba-and-panax-ginseng-on-driving-performance
#20
RANDOMIZED CONTROLLED TRIAL
Gregory S LaSala, Rita G McKeever, Urvi Patel, Jolene Okaneku, David Vearrier, Michael I Greenberg
CONTEXT: Panax ginseng and Gingko biloba are commonly used herbal supplements in the United States that have been reported to increase alertness and cognitive function. OBJECTIVE: The objective of this study was to investigate the effects of these specific herbals on driving performance. MATERIALS AND METHODS: 30 volunteers were tested using the STISIM3® Driving Simulator (Systems Technology Inc., Hawthorne, CA, USA) in this double-blind, placebo-controlled study...
February 2015: Clinical Toxicology
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