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methylprednisolone i.v m.s

C Zecca, C G Antozzi, V Torri Clerici, M Ferrazzini, R E Mantegazza, S Rossi, C Gobbi
BACKGROUND: Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION: We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We describe the frequency and impact of prolonged lymphopenia after DMF discontinuation at two tertiary MS centres. A 36-year-old female patient with multiple sclerosis was switched to DMF after 14 years of treatment with interferon beta-1a...
December 3, 2017: Acta Neurologica Scandinavica
V Lindberg-Larsen, S R Ostrowski, M Lindberg-Larsen, M L Rovsing, P I Johansson, H Kehlet
We wished to evaluate whether inhibition of the systemic inflammatory response by a single pre-operative dose of methylprednisolone reduced markers of early endothelial damage after fast-track total knee arthroplasty. We randomly allocated 70 patients undergoing elective unilateral total knee arthroplasty (1:1) to receive either pre-operative intravenous methylprednisolone 125 mg (methylprednisolone group) or isotonic saline (control group). All procedures were performed under spinal anaesthesia without a tourniquet, using a standardised multimodal analgesic regime...
October 2017: Anaesthesia
Niels Vincent Rekers, Tanja M Flaig, Marko J K Mallat, Marijke J Spruyt-Gerritse, Malu Zandbergen, Jacqueline D H Anholts, Ingeborg M Bajema, Marian C Clahsen-van Groningen, Jianxin Yang, Johan W de Fijter, Frans H J Claas, Susanne Brakemeier, Nils Lachmann, Reinhold Kreutz, Emile de Heer, Klemens Budde, Juliane Bolbrinker, Michael Eikmans
BACKGROUND: Glucocorticoid (GC)-refractory acute rejection (AR) is a risk factor for inferior renal allograft outcome. We investigated genetic predisposition to the response to steroid treatment of acute allograft rejection. METHODS: Single nucleotide polymorphisms of genes involved in GC signaling (GR, GLCCI1) and drug metabolism and transport (CYP3A5, ABCB1, and PXR) were analyzed in kidney transplant recipients (1995-2005, Leiden cohort, n = 153) treated with methylprednisolone...
September 2017: Transplantation
M E Evangelopoulos, V Koutoulidis, E Andreadou, D S Evangelopoulos, C Kilidireas
PURPOSE: Interruption of natalizumab (NTM) treatment in multiple sclerosis (MS) patients may be followed by disease reactivation. On the other hand, patients with positive John Cunningham virus (JCV) antibodies treated with NTM over 24 months demonstrate a higher risk for developing progressive multifocal encephalopathy (PML). No established therapeutic approach is available for treating these patients to prevent disease reactivation. MATERIALS AND METHODS: Of the MS patients treated with NTM at the authors' institution, 30 were found positive for JCV abs...
December 2016: International Journal of Neuroscience
Sandip A Shah, Kamlesh M Shah, Kinnari A Patel, Asha S Anand, Shailesh S Talati, Harsha P Panchal, Apurva A Patel, Sonia K Parikh, Bhavesh B Parekh, Shilin N Shukla, Shreeniwas S Raut
Beta thalassemia major, one of the most prevalent hemoglobinopathy throughout the word, can be cured by allogenic stem cell transplantation (SCT) (Bone Marrow Transplant 36:971-975, 2005). Many patients, however, lack a suitably matched related sibling donor. Unrelated umbilical cord blood (UCB) can be used as an alternative stem cell source for these patients. This report describes SCT for nine children with beta-thalassemia major using partially HLA-matched unrelated UCB. Conditioning included oral busulfan 16 mg/kg (day -10 to -7), cyclophosphamide (Cy) 200 mg/kg (day -5 to -2), fludarabine 90 mg/kg (day -13 to -11), and antithymocyte globulin (rabbit) 7...
March 2015: Indian Journal of Hematology & Blood Transfusion
C Feltrin, C A Cooper, N Mohamad-Fauzi, Vhv Rodrigues, L H Aguiar, S Gaudencio-Neto, L T Martins, Cem Calderón, A S Morais, I S Carneiro, T M Almeida, Ing Silva, J L Rodrigues, E A Maga, J D Murray, A B Libório, L R Bertolini, M Bertolini
The presence of the zona pellucida has been perceived as a requirement for the oviductal transfer of cloned embryos at early stages of development while protecting the embryo from an immune system response. We hypothesized that steroid hormone therapy could reduce a potential cellular immune response after the transfer of zona-free cloned embryos into the oviduct of recipient female goats. In Experiment 1, seven does were used to study the systemic immunosuppressant effect of the methylprednisolone administration (for 3 days) on blood cell counts...
August 2014: Reproduction in Domestic Animals, Zuchthygiene
A Comte, W Jdid, M N Guilhaume, I Kriegel, S Piperno-Neumann, V Dieras, T Dorval, J Y Pierga, P H Cottu, L Mignot, F C Bidard
Treatment of breast cancer meningeal carcinomatosis (MC) relies on intrathecal chemotherapy. Thiotepa is one of the few drugs approved in this setting, although no large cohort has been reported. The aim of our retrospective study is to describe survival and prognostic factors of breast cancer patients treated by intrathecal thiotepa. A search in the electronic database of the Institut Curie was performed and retrieved the patients diagnosed with breast cancer MC from 2000 to 2012 and who received at least one intrathecal injection of thiotepa...
December 2013: Journal of Neuro-oncology
J P Vinicki, S Catalan Pellet, C Pappalardo, V C Cruzat, M A Spinetto, D Dubinsky, I N Tiraboschi, H A Laborde, G Nasswetter
INTRODUCTION: Infections are the leading cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Invasive fungal infections (IFI) comprise a group of diseases caused by Cryptococcus, Histoplasma, Aspergillus and Candida. Few studies of IFI have been published in patients with SLE and associated factors have not been completely defined. OBJECTIVES: The objectives of this paper are to estimate the frequency of IFI in admitted patients with SLE in our hospital, to determine the risk factors associated with IFI in our patients with SLE, and to compare IFI group with a control group (SLE without IFI)...
August 2013: Lupus
V A H Sato, I D B Marques, P T Goldenstein, L P F Carmo, L B Jorge, S M O Titan, R T Barros, V Woronik
OBJECTIVE: To evaluate clinicopathological features and treatment response in patients with lupus nephritis (LN), comparing the childhood- and late-onset forms of the disease. METHODS: We retrospectively analyzed clinical presentation, treatment and evolution in patients diagnosed with LN by renal biopsy between 1999 and 2008. Patients were grouped by age-≤18 years (n = 23); and ≥50 years (n = 13)-and were followed for the first year of treatment. RESULTS: The baseline features of the childhood- and late-onset groups, respectively, were as follows: mean age, 15 ± 2 and 54 ± 5 years; female gender, 87% and 92%; hypertension, 87% and 77%; Systemic Lupus Erythematosus Disease Activity Index, 29 ± 9 and 17 ± 7 (p = 0...
August 2012: Lupus
R Zivadinov, M G Dwyer, S Hussein, E Carl, C Kennedy, M Andrews, D Hojnacki, M Heininen-Brown, L Willis, M Cherneva, N Bergsland, B Weinstock-Guttman
OBJECTIVE: To determine the effects of intravenous natalizumab and intramuscular interferon beta-1a (IFNβ-1a) on the volume of white-matter (WM) lesions and normal appearing brain tissue (NABT) undergoing voxel-wise (VW) increases in magnetization transfer ratio (MTR) suggestive of remyelination in patients with relapsing multiple sclerosis. METHODS: This prospective, open-label, single-blinded study enrolled patients with relapsing-remitting multiple sclerosis (RRMS) and relapsing secondary progressive multiple sclerosis (RSPMS) as well as a group of age/sex-matched healthy controls (n=22)...
August 2012: Multiple Sclerosis: Clinical and Laboratory Research
S Ilia, A-M Spanaki, M Raissaki, V I Spoulou, M-D Fitrolaki, M Kanariou, G Tzanakaki, G Briassoulis
We present a unique case of life-threatening pneumococcal meningitis complicated by vasculitis in a fully vaccinated 4-year-old female with the heptavalent conjugate vaccine for Streptococcus pneumoniae (PCV7). Serotype 23F was isolated in both blood and cerebral spinal fluid (CSF) samples. Pulses of methylprednisolone were promptly initiated in addition to antibiotics leading to a good recovery. CSF studies and magnetic resonance imaging (MRI) of the brain were used for diagnosis and monitoring the response to corticoid therapy...
December 2011: Neuropediatrics
Johannes Waiser, Klemens Budde, Manuela Schütz, Lutz Liefeldt, Birgit Rudolph, Constanze Schönemann, Hans-H Neumayer, Nils Lachmann
BACKGROUND: Antibody-mediated rejection (ABMR) following kidney transplantation is associated with poor allograft survival. Conventional treatment based on plasmapheresis (PPH) and the administration of intravenous immunoglobulins (IVIG) is not satisfactory. Two compounds, more specifically targeting B cells and plasma cells, may help to improve the prognosis: rituximab, a B-cell-depleting monoclonal antibody, and bortezomib, a proteasome inhibitor causing apoptosis of plasma cells. METHODS: Starting in February 2009, we treated 10 consecutive patients with ABMR according to current Banff criteria with one cycle of bortezomib [1...
March 2012: Nephrology, Dialysis, Transplantation
Caroline M Meers, Shana Wauters, Eric Verbeken, Hans Scheers, Bart Vanaudenaerde, Geert M Verleden, Dirk Van Raemdonck
BACKGROUND: Donor lungs are susceptible to aspiration in the period before and after brain death. We hypothesized that preemptive anti-inflammatory treatment may result in better graft performance as evaluated during ex vivo lung perfusion (EVLP). METHODS: Pigs (27.4 ± 8.3kg) were divided into four groups (n = 6). Group [S] was treated with steroids (methylprednisolone 10 mg/kg), group [M] with macrolides (clarithromycin 250 mg), and group [P] with placebo (saline)...
September 2011: Journal of Surgical Research
D V Sidnev, A G Sanadze, S I Dedaev, M Iu Karganov, I B Alchinova
We studied anti-acetylcholine receptor antibodies (ARAb) in 25 patients with myasthenia gravis before and after the immunosuppressive drug (steroid) therapy and in 22 patients before and after thymectomy. The clinical effect after the treatment was correlated with the reduction of ARAb levels by more than 20% in 62% of patients. The ARAb levels did not change, or even increased, in 15% patients despite the improvement of their clinical state. We showed the direct correlation between the clinical improvement and the decrease of ARAb level...
2010: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Amira A Shahin, Soha M El Desouky, Hania S Zayed
The aim of this work is to describe the outcome of a series of patients with hepatitis C virus (HCV)-related vasculitis who were treated with corticosteroids and I.V. cyclophosphamide without receiving any antiviral therapy. The data of 16 patients with HCV infection and vasculitis were retrospectively analyzed for the treatment outcome in the present study. Eleven patients were females (68.8%) with a mean age of 49.6 ± 10.0 years. Nine patients (56.2%) had medium-sized vessel vasculitis (group A) and seven patients (43...
May 2011: Clinical Rheumatology
G Vannucchi, I Campi, M Bonomi, D Covelli, D Dazzi, N Currò, S Simonetta, P Bonara, L Persani, C Guastella, J Wall, P Beck-Peccoz, M Salvi
In active Graves' orbitopathy (GO), proinflammatory cytokines predominate. Circulating thyroid stimulating hormone (TSH)-receptor antibodies (TRAb) have been correlated with GO clinical activity and severity. In preliminary studies rituximab (RTX), an anti-CD 20 monoclonal antibody, has induced clinical improvement of active GO without a change in serum anti-thyroid antibodies. We have studied whether RTX in GO acts by affecting proinflammatory cytokines and thyroid and orbital-directed antibodies. Ten patients with GO were treated with RTX, administered twice intravenously (i...
September 2010: Clinical and Experimental Immunology
V I Vasil'ev, S Kh Sedyshev, S G Radenska-Lopovok, O A Logvinenko, M V Simonova, E N Aleksandrova, T N Safonova, G R Fadienko, E Iu Varlamova, E L Nasonov
The authors present their experience in diagnosing and treating interstitial nephritis with the development of chronic renal failure in a patient with generalized sarcoidosis, by involving the intrathoracic and peripheral lymph nodes, liver, spleen, subcutaneous fat, lung, as well as with the severe salivary and lachrymal gland lesions that imitate the clinical picture of Schogren's disease.
2009: Terapevticheskiĭ Arkhiv
I Ingelmo Ingelmo, F Domínguez Pérez, J M Pinto Corraliza, N Fàbregas Julià, P Rama-Maceiras, J Hernández Palazón, R Badenes Quiles, J Burgos Flores, E Hevia Sierra, H Mhaidli Hamdan, C Barrios Pitarque, G Pizá Vallespir, I Sanpera Trigueros, P Doménech Fernández, I Alvarez García de Quesada, O Riquelme García, M García Alonso, R Ramos Galea, P Gutiérrez Carbonell, P Bas Hermida, J Bagó Granell, I González Barrios, G de Blas Beorlegui, P Calvo Calleja, J Conill Ramón, V E Cortés Doñate, M M González Hidalgo, V Izura Azanza, M C Maeztu Sardiña, J Moliner Ibáñez, I Regidor Bailly-Bailliere, A Sáenz de Cabezón-Alvarez, C Santiago Fernández, S Soler Algarra
No abstract text is available yet for this article.
February 2010: Revista Española de Anestesiología y Reanimación
A Bitto, B P Burnett, F Polito, R M Levy, H Marini, V Di Stefano, N Irrera, M A Armbruster, L Minutoli, D Altavilla, F Squadrito
BACKGROUND AND PURPOSE: Glucocorticoid-induced osteoporosis (GIO) is the leading cause of secondary osteoporosis. Clinical evidence suggests a role for genistein aglycone in the treatment of post-menopausal osteopenia although proof of efficacy in comparison with currently available treatments is still lacking. To clarify this issue, we investigated the effects of genistein on bone compared with alendronate in experimental GIO. EXPERIMENTAL APPROACH: A total of 28 female Sprague-Dawley rats were used...
April 2009: British Journal of Pharmacology
P L Silva, C S N B Garcia, P A Maronas, V R Cagido, E M Negri, N R Damaceno-Rodrigues, G M Ventura, P T Bozza, W A Zin, V L Capelozzi, P Pelosi, P R M Rocco
The present study compared the effects of early short-term with prolonged low-dose corticosteroid therapy in acute lung injury (ALI). In total, 120 BALB/c mice were randomly divided into five groups. In the control group, saline was intratracheally (i.t.) instilled. In the ALI group, mice received Escherichia coli lipopolysaccharide (10 microg i.t.). ALI animals were further randomised into four subgroups to receive saline (0.1 mL i.v.) or methylprednisolone (2 mg x kg(-1) i.v.) at 6 h, 24 h or daily (for 7 days, beginning at day 1)...
March 2009: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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