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https://www.readbyqxmd.com/read/28438231/health-technology-assessment-in-evaluation-of-pharmaceuticals-in-the-czech-republic
#1
Lenka Vostalová, Jana Mazelová, Jiří Samek, Milan Vocelka
OBJECTIVES: In the Czech Republic, the health technology assessment (HTA) approaches have been implemented in evaluation of medicinal products since 2008. The aim of this study was to provide an overview of the implementation of HTA and different levels thereof in the evaluation process conducted by the State Institute for Drug Control (SUKL) and to describe the impact of HTA on the entrance of new medicinal entities into out-patient healthcare system including highly innovative and orphan drugs...
April 25, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28435485/impact-of-health-policy-changes-on-emergency-medicine-in-maryland-stratified-by-socioeconomic-status
#2
Laura Pimentel, David Anderson, Bruce Golden, Edward Wasil, Fermin Barrueto, Jon M Hirshon
INTRODUCTION: On January 1, 2014, the financing and delivery of healthcare in the state of Maryland (MD) profoundly changed. The insurance provisions of the Patient Protection and Affordable Care Act (ACA) began implementation and a major revision of MD's Medicare waiver ushered in a Global Budget Revenue (GBR) structure for hospital reimbursement. Our objective was to analyze the impact of these policy changes on emergency department (ED) utilization, hospitalization practices, insurance profiles, and professional revenue...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28429251/air-water-co2-and-ch4-fluxes-along-a-river-reservoir-continuum-case-study-in-the-pengxi-river-a-tributary-of-the-yangtze-river-in-the-three-gorges-reservoir-china
#3
Yang Huang, Lindsey M W Yasarer, Zhe Li, Belinda S M Sturm, Zengyu Zhang, Jinsong Guo, Yu Shen
Water surface greenhouse gas (GHG) emissions in freshwater reservoirs are closely related to limnological processes in the water column. Affected by both reservoir operation and seasonal changes, variations in the hydro-morphological conditions in the river-reservoir continuum will create distinctive patterns in water surface GHG emissions. A one-year field survey was carried out in the Pengxi River-reservoir continuum, a part of the Three Gorges Reservoir (TGR) immediately after the TGR reached its maximum water level...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28427846/vaccines-are-different-a-systematic-review-of-budget-impact-analyses-of-vaccines
#4
REVIEW
Priscilla Magalhaes Loze, Luciana Bertholim Nasciben, Ana Marli Christovam Sartori, Alexander Itria, Hillegonda Maria Dutilh Novaes, Patrícia Coelho de Soárez
INTRODUCTION: Several countries require manufacturers to present a budget impact analysis (BIA), together with a cost-effectiveness analysis, to support national funding requests. However, guidelines for conducting BIA of vaccines are scarce. OBJECTIVES: To analyze the methodological approaches used in published budget impact analysis (BIA) of vaccines, discussing specific methodological issues related to vaccines. MATERIAL AND METHODS: This systematic review of the literature on BIA of vaccines was carried out in accordance with the Centre for Reviews and Dissemination - CRD guidelines...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28418263/systematic-bias-in-predictions-of-new-drugs-budget-impact-analysis-of-a-sample-of-recent-us-drug-launches
#5
Michael S Broder, Jenelle M Zambrano, Jackie Lee, Richard S Marken
OBJECTIVE: Expectations about the budget impact of new drug launches may affect payer behavior and ultimately consumer costs. Therefore, we evaluated the accuracy of pre-launch US budget impact estimates for a sample of new drugs. METHODS: We searched for publicly available budget impact estimates made pre-launch for drugs approved in the US from 1(st) September 2010 to 1(st) September 2015 and compared them to actual sales. Accuracy was calculated as the ratio of pre-launch estimate to actual sales...
April 18, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28413923/knowledge-of-healthy-foods-does-not-translate-to-healthy-snack-consumption-among-exercise-science-undergraduates
#6
Laura H McArthur, Antonette Valentino, Donald Holbert
This cross-sectional survey study compared the on- and off-campus snack choices and related correlates of convenience samples of exercise science (ES) ( n = 165, M = 45%, F = 55%) and non-exercise science (NES) ( n =160, M = 43%, F = 57%) undergraduates. The hypothesis posed was that knowledge of healthy foods will not translate to healthier snack consumption by the ES students, and that the snack choices and related correlates of ES and NES students will be similar. Data were collected using self-administered questionnaires completed in classrooms (ES sample) and at high-traffic locations on-campus (NES sample)...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28408097/crisis-in-the-health-sector-impact-on-nurses-working-conditions
#7
Alberto Granero-Lázaro, Josep M Blanch-Ribas, Juan Francisco Roldán-Merino, Jordi Torralbas-Ortega, Ana María Escayola-Maranges
In a context of economic crisis and policies to reduce the public deficit, the budgets of the Catalan Health Institute (CHI) were cut by 15.33% between 2010 and 2014. OBJECTIVE: To assess the perceived impact on nurses' work conditions of measures to contain health spending. METHOD: The study design was descriptive and transversal. A sample of 1,760 nurses from the province of Barcelona answered a questionnaire on the perceived impact of health spending containment measures implemented in their workplace during the early years of the crisis...
April 10, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28399974/evaluation-of-the-tuberculosis-infection-control-training-center-tajikistan-2014-2015
#8
C Scott, J Mangan, Z Tillova, P A Jensen, S Ahmedov, J Ismoilova, A Trusov
SETTING: Training center on tuberculosis (TB) infection control (IC) for health care workers in the Central Asian Republics region. OBJECTIVE: To assess the effects of TB IC training courses conducted at the Tuberculosis Infection Control Training Center in Machiton, Tajikistan. DESIGN: Participants who participated in training (n = 89) during the first year of operation (April 2014-February 2015) were invited to participate in a post-training interview...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28397647/can-science-feed-on-a-crisis-expectations-the-pine-institute-and-the-decline-of-the-french-resin-industry
#9
Marcin Krasnodębski
Argument While science and economy are undoubtedly interwoven, the nature of their relationship is often reduced to a positive correlation between economic and scientific prosperity. It seems that the modern scholarship focusing on "success stories" tends to neglect counterintuitive examples such as the impact of economic crises on research. We argue that economic difficulties, under certain circumstances, may also lead to the prosperous development of scientific institutions. This paper focuses on a particular organism, the Pine Institute in Bordeaux in France...
March 2017: Science in Context
https://www.readbyqxmd.com/read/28397080/the-rituximab-biosimilar-ct-p10-in-rheumatology-and-cancer-a-budget-impact-analysis-in-28-european-countries
#10
László Gulácsi, Valentin Brodszky, Petra Baji, Fanni Rencz, Márta Péntek
INTRODUCTION: New biosimilars of monoclonal antibodies are anticipated to bring significant cost savings and increase access to treatment. The rituximab biosimilar CT-P10 has recently been approved in Europe in all indications held by reference rituximab (RTX), including rheumatoid arthritis, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia. We analyzed the budgetary impact of the introduction of CT-P10 into the European Union (EU) for use in patients with rheumatoid arthritis and cancer diagnoses, using a budget impact analysis model...
April 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28393869/enhanced-methane-emissions-from-tropical-wetlands-during-the-2011-la-ni%C3%A3-a
#11
Sudhanshu Pandey, Sander Houweling, Maarten Krol, Ilse Aben, Guillaume Monteil, Narcisa Nechita-Banda, Edward J Dlugokencky, Rob Detmers, Otto Hasekamp, Xiyan Xu, William J Riley, Benjamin Poulter, Zhen Zhang, Kyle C McDonald, James W C White, Philippe Bousquet, Thomas Röckmann
Year-to-year variations in the atmospheric methane (CH4) growth rate show significant correlation with climatic drivers. The second half of 2010 and the first half of 2011 experienced the strongest La Niña since the early 1980s, when global surface networks started monitoring atmospheric CH4 mole fractions. We use these surface measurements, retrievals of column-averaged CH4 mole fractions from GOSAT, new wetland inundation estimates, and atmospheric δ(13)C-CH4 measurements to estimate the impact of this strong La Niña on the global atmospheric CH4 budget...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393687/biosimilars-for-the-management-of-inflammatory-bowel-diseases-economic-considerations
#12
Laszlo Gulacsi, Marta Pentek, Fanni Rencz, Valentin Brodszky, Petra Baji, Zsuzsanna Vegh, Krisztina B Gecse, Silvio Danese, Laurent Peyrin-Biroulet, Peter L Lakatos
Biological drugs revolutionized the treatment of inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. However, not all clinically eligible patients have access to biologicals, due to significant costs and budget impact. Biosimilars are highly comparable to their originator product in terms of clinical efficacy and safety. Biosimilars are priced 15-75% lower than their reference product, which makes them a less costly alternative and is expected to offer better patients access to biologicals...
April 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28388648/trends-in-medicines-procurement-by-the-brazilian-federal-government-from-2006-to-2013
#13
Tatiana Chama Borges Luz, Claudia Garcia Serpa Osorio-de-Castro, Rachel Magarinos-Torres, Bjorn Wettermark
The costs of medicines pose a growing burden on healthcare systems worldwide. A comprehensive understanding of current procurement processes provides strong support for the development of effective policies. This study examined Brazilian Federal Government pharmaceutical procurement data provided by the Integrated System for the Administration of General Services (SIASG) database, from 2006 to 2013. Medicine purchases were aggregated by volume and expenditure for each year. Data on expenditure were adjusted for inflation using the Extended National Consumer Price Index (IPCA) for December 31, 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28387336/using-energy-budgets-to-combine-ecology-and-toxicology-in-a-mammalian-sentinel-species
#14
Jean-Pierre W Desforges, Christian Sonne, Rune Dietz
Process-driven modelling approaches can resolve many of the shortcomings of traditional descriptive and non-mechanistic toxicology. We developed a simple dynamic energy budget (DEB) model for the mink (Mustela vison), a sentinel species in mammalian toxicology, which coupled animal physiology, ecology and toxicology, in order to mechanistically investigate the accumulation and adverse effects of lifelong dietary exposure to persistent environmental toxicants, most notably polychlorinated biphenyls (PCBs). Our novel mammalian DEB model accurately predicted, based on energy allocations to the interconnected metabolic processes of growth, development, maintenance and reproduction, lifelong patterns in mink growth, reproductive performance and dietary accumulation of PCBs as reported in the literature...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386886/quantitative-study-on-nitrogen-deposition-and-canopy-retention-in-mediterranean-evergreen-forests
#15
Anna Avila, Laura Aguillaume, Sheila Izquieta-Rojano, Héctor García-Gómez, David Elustondo, Jesús Miguel Santamaría, Rocío Alonso
To assess the impact of nitrogen (N) pollutants on forest ecosystems, the role of the interactions in the canopy needs to be understood. A great number of studies have addressed this issue in heavily N-polluted regions in north and central Europe. Much less information is available for the Iberian Peninsula, and yet this region is home to mountain forests and alpine grasslands that may be at risk due to excessive N deposition. To establish the basis for ecology-based policies, there is a need to better understand the forest response to this atmospheric impact...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28380059/impact-of-the-spatial-resolution-of-satellite-remote-sensing-sensors-in-the-quantification-of-total-suspended-sediment-concentration-a-case-study-in-turbid-waters-of-northern-western-australia
#16
Passang Dorji, Peter Fearns
The impact of anthropogenic activities on coastal waters is a cause of concern because such activities add to the total suspended sediment (TSS) budget of the coastal waters, which have negative impacts on the coastal ecosystem. Satellite remote sensing provides a powerful tool in monitoring TSS concentration at high spatiotemporal resolution, but coastal managers should be mindful that the satellite-derived TSS concentrations are dependent on the satellite sensor's radiometric properties, atmospheric correction approaches, the spatial resolution and the limitations of specific TSS algorithms...
2017: PloS One
https://www.readbyqxmd.com/read/28378734/-pharmacoeconomic-aspects-of-macitentan-in-the-therapy-of-pulmonary-arterial-hypertension
#17
O M Moiseeva, A V Rudakova
AIM: To provide a pharmacoeconomic estimate of macitentan versus bosentan in therapy for pulmonary arterial hypertension (PAH). SUBJECT AND METHODS: An analysis was carried out on the basis of a social perspective for patients, whose mean age was 50 years. A budget impact analysis was performed without discounting; with the time horizon of the study being 5 years. Assessing the cost- effectiveness of endothelin receptor antagonists used a Markov model based on the meta-analysis of clinical trials...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28370293/a-framework-for-predicting-impacts-on-ecosystem-services-from-sub-organismal-responses-to-chemicals
#18
REVIEW
Valery E Forbes, Chris J Salice, Bjorn Birnir, Randy J F Bruins, Peter Calow, Virginie Ducrot, Nika Galic, Kristina Garber, Bret C Harvey, Henriette Jager, Andrew Kanarek, Robert Pastorok, Steve F Railsback, Richard Rebarber, Pernille Thorbek
Protection of ecosystem services is increasingly emphasized as a risk-assessment goal, but there are wide gaps between current ecological risk-assessment endpoints and potential effects on services provided by ecosystems. The authors present a framework that links common ecotoxicological endpoints to chemical impacts on populations and communities and the ecosystem services that they provide. This framework builds on considerable advances in mechanistic effects models designed to span multiple levels of biological organization and account for various types of biological interactions and feedbacks...
April 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28363186/a-model-to-evaluate-the-costs-and-clinical-effectiveness-of-human-papilloma-virus-screening-compared-with-annual-papanicolaou-cytology-in-germany
#19
Karl Ulrich Petry, Cordula Barth, Jürgen Wasem, Anja Neumann
OBJECTIVES: We modelled human papilloma virus (HPV) primary screening scenarios compared with Pap cytology to evaluate clinical effectiveness and projected annual costs in Germany. STUDY DESIGN: A Markov cohort model was built to compare the budget impact of annual Pap cytology with different 5-yearly HPV screening scenarios: (1) a positive HPV test followed by Pap cytology; (2) a positive HPV test followed by p16/Ki-67 dual-stained cytology; (3) a positive HPV test followed by colposcopy if HPV-16/18-positive or p16/Ki-67 dual-stained cytology if positive for other subtypes; (4) co-testing with HPV and Pap...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28361278/cost-effectiveness-of-gastroprotection-with-proton-pump-inhibitors-in-older-low-dose-acetylsalicylic-acid-users-in-the-netherlands
#20
Sek Hung Chau, Reinier L Sluiter, Wietske Kievit, Michel Wensing, Martina Teichert, Jacqueline G Hugtenburg
PURPOSE: The present study aimed to assess the cost effectiveness of concomitant proton pump inhibitor (PPI) treatment in low-dose acetylsalicylic acid (LDASA) users at risk of upper gastrointestinal (UGI) adverse effects as compared with no PPI co-medication with attention to the age-dependent influence of PPI-induced adverse effects. METHODS: We used a Markov model to compare the strategy of PPI co-medication with no PPI co-medication in older LDASA users at risk of UGI adverse effects...
March 30, 2017: Drugs & Aging
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