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https://www.readbyqxmd.com/read/29676708/-urticaria-multiforme-difficult-to-distinguish-from-other-skin-conditions
#1
L Zijp, P M J H Kemperman, G W den Tusscher
BACKGROUND: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children. CASE DESCRIPTION: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. CONCLUSION: The diagnosis of urticaria multiforme can be made on the basis of the clinical picture. Treatment is symptomatic and in most cases this condition resolves spontaneously within two weeks...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676526/crimean-congo-haemorrhagic-fever-virus-past-present-and-future-insights-for-animal-modelling-and-medical-countermeasures
#2
REVIEW
E J Mendoza, B Warner, D Safronetz, C Ranadheera
Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral zoonosis with a case-fatality rate ranging from 9% to 50% in humans. Although a licensed vaccine to prevent infection by the CCHF virus (CCHFV) exists, its ability to induce neutralizing antibodies is limited and its efficacy against CCHFV remains undetermined. In addition, controlling CCHF infections by eradication of the tick reservoir has been ineffective, both economically and logistically, and the treatment options for CCHF remain limited...
April 20, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29676052/rapamycin-protects-against-early-brain-injury-independent-of-cerebral-blood-flow-changes-in-a-mouse-model-of-subarachnoid-haemorrhage
#3
Kazumasu Sasaki, Shuzo Yamamoto, Tatsushi Mutoh, Yoshiharu Tsuru, Yasuyuki Taki, Ryuta Kawashima
We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). The ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < ...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29675969/exercise-induced-pulmonary-haemorrhage-in-thoroughbred-racehorses-a-longitudinal-study
#4
E J Crispe, C J Secombe, D I Perera, A A Manderson, B A Turlach, G D Lester
BACKGROUND: Exercise induced pulmonary haemorrhage (EIPH) is considered a progressive disease based on histopathology, but it is unknown if tracheobronchoscopic EIPH severity worsens over time. OBJECTIVES: The aim of this study was to examine tracheobronchoscopic EIPH changes over time in a population of Thoroughbred racehorses. A secondary aim was to identify factors that affect changes in tracheobronchoscopic EIPH severity between observations. STUDY DESIGN: Prospective, longitudinal, observational cross-sectional study...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29675941/anticoagulation-in-the-management-of-neonatal-cerebral-sinovenous-thrombosis-a-systematic-review-and-meta-analysis
#5
REVIEW
Thomas Rossor, Tomoki Arichi, Sanjay Bhate, Anthony R Hart, Rahul Raman Singh
AIM: To determine whether anticoagulation therapy (ACT) in the treatment of neonatal cerebral sinovenous thrombosis (CSVT) improves outcomes, in the presence or absence of pre-existing intracerebral haemorrhage (ICH). METHOD: We searched CENTRAL, MEDLINE, Embase, CINAHL, the Web of Science, and clinical trial databases. We considered data from retrospective and prospective cohort studies, case series, and randomized controlled studies evaluating outcomes of CSVT treated with anticoagulation or no anticoagulation...
April 19, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29675658/iodine-concentration-a-new-important-characteristic-of-the-spot-sign-that-predicts-haematoma-expansion
#6
Fan Fu, Shengjun Sun, Liping Liu, Jianying Li, Yaping Su, Yingying Li
OBJECTIVES: The computed tomography angiography (CTA) spot sign is a validated predictor of haematoma expansion (HE) in spontaneous intracerebral haemorrhage (SICH). We investigated whether defining the iodine concentration (IC) inside the spot sign and the haematoma on Gemstone spectral imaging (GSI) would improve its sensitivity and specificity for predicting HE. METHODS: From 2014 to 2016, we prospectively enrolled 65 SICH patients who underwent single-phase spectral CTA within 6 h...
April 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29675259/successful-neoadjuvant-peptide-receptor-radionuclide-therapy-for-an-inoperable-pancreatic-neuroendocrine-tumour
#7
Tiago Nunes da Silva, M L F van Velthuysen, Casper H J van Eijck, Jaap J Teunissen, J Hofland, Wouter W de Herder
Non-functional pancreatic neuroendocrine tumours (NETs) can present with advanced local or distant (metastatic) disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT) using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29674403/unexpected-case-of-pneumomediastinum-and-subcutaneous-emphysema-primary-or-secondary-aetiology
#8
Amanda J L Cheng, Timothy J Sadler
A 77-year-old man was admitted with a relapse of antineutrophil cytoplasmic antibody-positive vasculitis with pulmonary involvement and acute kidney injury. There was a background of pulmonary fibrosis (non-specific interstitial pneumonia type pattern) and superadded pulmonary haemorrhage, acute pulmonary oedema and sepsis. The patient was intubated for 4 days and remained dependent on high flow oxygen and continuous positive airway pressure after extubation. A chest radiograph performed 2 weeks after extubation demonstrated unexpected, extensive pneumomediastinum and subcutaneous emphysema...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674371/automation-of-ct-based-haemorrhagic-stroke-assessment-for-improved-clinical-outcomes-study-protocol-and-design
#9
Betty Chinda, George Medvedev, William Siu, Martin Ester, Ali Arab, Tao Gu, Sylvain Moreno, Ryan C N D'Arcy, Xiaowei Song
INTRODUCTION: Haemorrhagic stroke is of significant healthcare concern due to its association with high mortality and lasting impact on the survivors' quality of life. Treatment decisions and clinical outcomes depend strongly on the size, spread and location of the haematoma. Non-contrast CT (NCCT) is the primary neuroimaging modality for haematoma assessment in haemorrhagic stroke diagnosis. Current procedures do not allow convenient NCCT-based haemorrhage volume calculation in clinical settings, while research-based approaches are yet to be tested for clinical utility; there is a demonstrated need for developing effective solutions...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674368/effectiveness-of-the-facility-based-maternal-near-miss-case-reviews-in-improving-maternal-and-newborn-quality-of-care-in-low-income-and-middle-income-countries-a-systematic-review
#10
Marzia Lazzerini, Sonia Richardson, Valentina Ciardelli, Anna Erenbourg
OBJECTIVES: The maternal near-miss case review (NMCR) has been promoted by WHO as an approach to improve quality of care (QoC) at facility level. This systematic review synthesises evidence on the effectiveness of the NMCR on QoC and maternal and perinatal health outcomes in low-income and middle-income countries (LMICs). METHODS: Studies were searched for in six electronic databases (MEDLINE, Index Medicus, Web of Science, the Cochrane library, Embase, LILACS), with no language restrictions...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674196/clinical-and-imaging-profile-of-patients-with-new-onset-seizures-a-presumptive-diagnosis-of-eclampsia-a-prospective-observational-study
#11
Vandana Bojja, Anish Keepanasseril, Pradeep P Nair, V C Sunitha
OBJECTIVE: To study the clinical and imaging profile of patients with new-onset seizures with a presumptive diagnosis of eclampsia. METHODS: This was a cross-sectional study, conducted in a tertiary teaching hospital, on pregnant women presenting with new onset seizures with presumptive diagnosis of eclampsia excluding those with pre-existing neurological conditions. Demographic details, medical and obstetric examination findings were noted. All women underwent neuroimaging within 5 days of onset seizures...
February 25, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674053/chimeric-dna-lna-based-biosensor-for-the-rapid-detection-of-african-swine-fever-virus
#12
Massimo Biagetti, Massimiliano Cuccioloni, Laura Bonfili, Valentina Cecarini, Carla Sebastiani, Ludovica Curcio, Monica Giammarioli, Gian Mario De Mia, Anna Maria Eleuteri, Mauro Angeletti
African swine fever (ASF) virus is a DNA virus responsible for a severe haemorrhagic fever in pigs, which (still in the absence of vaccination strategies) results in high mortality rates. Herein, we present a biosensor-based method for the detection of ASF viral DNA in the blood of pigs. The biosensor exploits a single-strand DNA probe with locked nucleic acid nucleotides (LNA) substitutions as the complementary recognition element for the conserved region of vp72 gene of ASF virus. The biosensor was calibrated using qPCR-quantified ASF viral DNA extracted from the blood of pigs experimentally infected with the virulent Italian isolate 49/08, genotype I...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673921/bicyclist-s-vulva-diagnostic-and-therapeutic-aspects
#13
A Grouin, S Rouquette, M Saïdani, S Henno, V Lavoué, J Levêque
The authors report a case of a rare vulvar condition in a young cyclist, known as bicyclist's vulva. The diagnosis was based on the clinical context (intensive cycling training with repeated saddle sores, responsible for painless unilateral swelling of the labium majus to a significant size and functional discomfort). Imaging examinations were used to characterise the lesion and its relationship with the pelvic organs. The lesion was composed of connective tissue, poorly demarcated and heavily collagenised without necrotic or haemorrhagic areas...
April 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29673086/fatal-leptospirosis-in-free-ranging-eurasian-beavers-castor-fiber-l-switzerland
#14
N Marreros, S Zürcher-Giovannini, F C Origgi, Z Djelouadji, J Wimmershoff, M Pewsner, E Akdesir, M Batista Linhares, A Kodjo, M-P Ryser-Degiorgis
Leptospirosis was first diagnosed in free-ranging Eurasian beavers (Castor fiber L.) in Switzerland in 2010. Pathologic, serologic, molecular and epidemiologic analyses were carried out on 13 animals submitted for necropsy from 2010 through 2014. Typical lesions included alveolar haemorrhages in the lungs, tubular degeneration and interstitial nephritis in the kidneys. Microscopic agglutination test results were positive for serogroups Icterohaemorrhagiae, Australis, Autumnalis and Sejroe. Molecular analysis identified four distinct profiles belonging to serovar Icterohaemorrhagiae or Copenhageni...
April 19, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#15
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29672696/infant-abuse-diagnosis-associated-with-abusive-head-trauma-criteria-incidence-increase-due-to-overdiagnosis
#16
Ulf Högberg, Erik Lampa, Göran Högberg, Peter Aspelin, Fredrik Serenius, Ingemar Thiblin
Background: The hypothesis of this study is that the diagnosis of infant abuse is associated with criteria for shaken baby syndrome (SBS)/abusive head trauma (AHT), and that that changes in incidence of abuse diagnosis in infants may be due to increased awareness of SBS/AHT criteria. Methods: This was a population-based register study. Setting: Register study using the Swedish Patient Register, Medical Birth Register, and Cause of Death Register. The diagnosis of infant abuse was based on the International Classification of Diseases, 9th and 10th revision...
April 17, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29669856/the-luna-aneurysm-embolisation-system-for-intracranial-aneurysm-treatment-short-term-mid-term-and-long-term-clinical-and-angiographic-results
#17
Michel Piotin, Alessandra Biondi, Nader Sourour, Charbel Mounayer, Maciej Jaworski, Salvatore Mangiafico, Tommy Andersson, Michael Söderman, Pierre Goffette, René Anxionnat, Raphaël Blanc
BACKGROUND AND PURPOSE: Intrasaccular aneurysm flow disruption represents an emerging endovascular approach to treat intracranial aneurysms. The purpose of this study was to determine the clinical and angiographic outcomes of using the LUNA aneurysm embolisation system (AES) for treatment of intracranial aneurysms. MATERIALS AND METHODS: The LUNA AES Post-Market Clinical Follow-Up study is a prospective, multicentre, single-arm study that was designed to evaluate device safety and efficacy...
April 18, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#18
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29667909/losartan-does-not-decrease-renal-oxygenation-and-norepinephrine-effects-in-rats-after-resuscitated-haemorrhage
#19
Sofia Jönsson, Jacqueline M Melville, Mediha Becirovic-Agic, Michael Hultström
Renin-angiotensin-system blockers are thought to increase the risk of acute kidney injury after surgery and haemorrhage. We found that Losartan does not cause renal cortical hypoxia after haemorrhage in rats because of decreased renal vascular resistance, but did not evaluate resuscitation. AIM: Study Losartan´s effect on renal cortical and medullary oxygenation, and norepinephrine´s vasopressor effect in a model of resuscitated haemorrhage. METHOD: After seven days Losartan (60 mg/kg/day) or control treatment, male Wistar rats were haemorrhaged 20 % of the blood volume and resuscitated with Ringer's Acetate...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667872/detecting-european-rabbit-oryctolagus-cuniculus-disease-outbreaks-by-monitoring-digital-media
#20
David E Peacock, Tiggy L Grillo
  Digital media and digital search tools offer simple and effective means to monitor for pathogens and disease outbreaks in target organisms. Using tools such as Rich Site Summary feeds, and Google News and Google Scholar specific key word searches, international digital media were actively monitored from 2012 to 2016 for pathogens and disease outbreaks in the taxonomic order Lagomorpha, with a specific focus on the European rabbit ( Oryctolagus cuniculus). The primary objective was identifying pathogens for assessment as potential new biocontrol agents for Australia's pest populations of the European rabbit...
April 18, 2018: Journal of Wildlife Diseases
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