keyword
https://read.qxmd.com/read/38533305/the-primary-prevention-of-pancreatic-fistula-using-a-vascularised-rectus-abdominis-muscle-flap-a-porcine-model
#1
JOURNAL ARTICLE
A W J Wong, N H S Sim, J H Kam, R Rajarethinam, B K Tan, A Y H Tan
BACKGROUND: A pancreatic fistula is one of the most devastating complications following a Whipple's procedure. Fistula rates remain high despite various modifications to surgical techniques. We propose the use of a vascularised muscle flap in the primary prevention of pancreatic fistulas. METHOD: A distal pancreatectomy was performed on 5 pigs in our porcine model. A pancreaticojejunal (PJ) anastomotic leak was simulated. The pigs were divided into treatment (4 pigs) and control groups (1 pig)...
June 2024: JPRAS Open
https://read.qxmd.com/read/38533126/innate-immune-response-of-rainbow-trout-erythrocytes-to-spinycterins-expressing-a-downsized-viral-fragment-of-viral-haemorrhagic-septicaemia-virus
#2
JOURNAL ARTICLE
S Puente-Marin, D Cazorla, V Chico, J Coll, M Ortega-Villaizan
Recent studies have reported on the importance of RBCs in fish responses to viral infections and DNA vaccines. Surface-displaying recombinant bacterins (spinycterins) are a safe and adaptable prototype for viral vaccination of fish and represent an alternative method of aquaculture prophylaxis, since have been reported to enhance fish immune response. We evaluated the innate immune response of rainbow trout ( Oncorhynchus mykiss ) red blood cells (RBCs), head kidney, and spleen to spinycterins expressing a fragment of the glycoprotein G of viral haemorrhagic septicemia virus (VHSV), one of the most devastating world-wide diseases in farmed salmonids...
April 15, 2023: Aquaculture
https://read.qxmd.com/read/38532494/epidemiological-characterization-and-risk-assessment-of-rabbit-haemorrhagic-disease-virus-2-rhdv2-b-gi-2-in-the-world
#3
JOURNAL ARTICLE
Zhuo Sun, Qi An, Yuepeng Li, Xiang Gao, Hongbin Wang
A novel variant of rabbit haemorrhagic disease virus, designated RHDV2/b/GI.2, was first discovered in France in 2010. Subsequently, RHDV2 rapidly spread to Africa, North America, Australia, and Asia. RHDV2 outbreaks have resulted in significant economic losses in the global rabbit industry and disrupted the balance of natural ecosystems. Our study investigated the seasonal characteristics of RHDV2 outbreaks using seasonal indices. RHDV2 is prone to causing significant outbreaks within domestic and wild rabbit populations during the spring season and is more likely to induce outbreaks within wild rabbit populations during late autumn in the Southern Hemisphere...
March 26, 2024: Veterinary Research
https://read.qxmd.com/read/38532199/occurrence-and-characterization-of-proteus-mirabilis-from-infected-farmed-african-catfish-in-ogun-state-nigeria
#4
JOURNAL ARTICLE
Olayinka Remilekun Anifowose, Gbolahanmi Akinola Oladosu, Oladipo Olufemi Omotosho
BACKGROUND: Bacterial pathogens are the causative agents of some of the most serious disease problems in cultured fish causing mortalities and severe economic losses. This study was conducted to determine the occurrence and characterization of Proteus mirabilis from infected farmed African catfish in Ogun State, Nigeria. METHODOLOGY: The bacteria were isolated from diseased farmed African catfish (Clarias gariepinus, n=128) with clinical signs of skin haemorrhages, ulceration, and ascites purposively sampled from farms within three senatorial districts namely Ogun East (OE; n=76), Ogun Central (OC; n=30) and Ogun West (OW; n=22) in Ogun State...
March 26, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38531550/blood-pressure-trends-following-birth-in-infants-born-under-25-weeks-gestational-age-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Emma Persad, Björn Brindefalk, Alexander Rakow
OBJECTIVE: The aim of our study was to describe postnatal blood pressure (BP) trends and evaluate relevant dynamics and outcomes for a subgroup of extremely preterm (EPT) infants. DESIGN: Retrospective observational cohort study. SETTING: Patients admitted to Karolinska University Hospital Stockholm. PATIENTS: EPT infants born between 22+0 and 24+6 weeks' gestational age (GA) undergoing invasive, continuous BP monitoring through an umbilical arterial catheter...
March 25, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38528572/characteristics-of-traumatic-major-haemorrhage-in-a-tertiary-trauma-center
#6
JOURNAL ARTICLE
Pieter van Wyk, Marcus Wannberg, Anna Gustafsson, Jane Yan, Agneta Wikman, Louis Riddez, Carl-Magnus Wahlgren
BACKGROUND: Major traumatic haemorrhage is potentially preventable with rapid haemorrhage control and improved resuscitation techniques. Although advances in prehospital trauma management, haemorrhage is still associated with high mortality. The aim of this study was to use a recent pragmatic transfusion-based definition of major bleeding to characterize patients at risk of major bleeding and associated outcomes in this cohort after trauma. METHODS: This was a retrospective cohort study including all trauma patients (n = 7020) admitted to a tertiary trauma center from January 2015 to June 2020...
March 25, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38525740/risk-factors-analysis-for-90-day-mortality-of-adult-patients-with-mild-traumatic-brain-injury-in-an-italian-emergency-department
#7
JOURNAL ARTICLE
Daniele Orso, Giulia Furlanis, Alice Romanelli, Federica Gheller, Marzia Tecchiolli, Franco Cominotto
Purpose : The most prominent risk factors for mortality after mild traumatic brain injury (TBI) have not been established. This study aimed to establish risk factors related to 90-day mortality after a traumatic event. Methods : A retrospective cohort study on adult patients entering the Emergency Department of the University Hospital of Trieste for mild TBI from 1 January 2020 to 31 December 2020 was conducted. Results : The final population was 1221 patients (median age of 78 years). The 90-day mortality rate was 7% (90 patients)...
February 23, 2024: Geriatrics
https://read.qxmd.com/read/38525703/recurrent-intracerebral-haematomas-due-to-amyloid-angyopathy-after-lyodura-transplantation-in-childhood
#8
Maša Fabjan, Ana Jurečič, Miha Jerala, Janja Pretnar Oblak, Senta Frol
The number of published cases of presumed iatrogenic cerebral amyloid angiopathy (iCAA) due to the transmission of amyloid β during neurosurgery is slowly rising. One of the potential ways of transmission is through a cadaveric dura mater graft (LYODURA) exposure during neurosurgery. This is a case of a 46-year-old female patient with no chronic conditions who presented with recurrent intracerebral haemorrhages (ICHs) without underlying vessel pathology. Four decades prior, the patient had a neurosurgical procedure with documented LYODURA transplantation...
March 4, 2024: Neurology International
https://read.qxmd.com/read/38525626/implementing-e-motive-for-detection-and-treatment-of-postpartum-haemorrhage-in-south-africa
#9
JOURNAL ARTICLE
M Singata-Madliki, S Fawcus, N Moran, E Arends, E Muller, S Mandondo, G J Hofmeyr
Postpartum haemorrhage is the leading cause of preventable maternal mortality in South Africa. In a significant breakthrough in the management of PPH, the E-MOTIVE trial found that a multifaceted health service intervention reduced severe PPH after vaginal delivery by 60% in 78 hospitals in Nigeria, Kenya, Tanzania and SA. The E-MOTIVE approach comprises objective blood loss measurement monitored every 15 minutes during the first hour after delivery to detect PPH early and trigger a bundle of first-line treatments, including massaging the uterus, oxytocin infusion, tranexamic acid infusion, intravenous crystalloid fluids, examination for the cause, emptying the bladder and, if necessary, escalation of care...
December 4, 2023: South African Medical Journal
https://read.qxmd.com/read/38525460/bilateral-vision-loss-at-high-altitude-a-diagnostic-dilemma
#10
Radhika Gupta, Apoorva Shukla, Blessy Mathew
A young male patient of 22 years inducted at 11,000 feet altitude presented with a sudden onset bilateral diminution of vision associated with easy fatiguability and generalised weakness. Fundus examination revealed preretinal haemorrhages and Roth spots both eyes, owing to which differential diagnosis of high altitude retinopathy (HAR) and haematological disorders was considered. On systemic examination, he had pallor with massive splenomegaly. Haematological investigation revealed high total leucocyte count (TLC) 2...
2024: Medical Journal, Armed Forces India
https://read.qxmd.com/read/38525228/serological-characterisation-of-lagovirus-virus-like-particles-originating-from-native-and-mutated-vp60-of-rabbit-haemorrhagic-disease-virus-2-and-european-brown-hare-syndrome-virus
#11
JOURNAL ARTICLE
Martyna Krejmer-Rąbalska, Marta Peplińska, Bogusław Szewczyk, Andrzej Fitzner
INTRODUCTION: Since lagoviruses cannot be cultivated in vitro , using expression systems is an alternative and promising way of producing diagnostic viral antigens. It opens up their use as active immunogens for vaccine production. MATERIAL AND METHODS: Virus-like particles (VLPs) were produced in a baculovirus expression system in Spodoptera frugiperda 9 (Sf9) insect cells based on wild-type and mutated variants of the virus capsid VP60 protein from a Polish strain of European brown hare syndrome virus (EBHSV) and wild-type and mutated versions of this protein from a Polish strain of rabbit haemorrhagic disease virus 2 (RHDV2)...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38523352/comparative-proteome-analysis-revealed-potential-biomarkers-and-the-underlying-immune-mechanisms-in-vibrio-resistant-hybrid-grouper-epinephelus-fuscoguttatus-%C3%A2-%C3%A2-%C3%A3-%C3%A2-epinephelus-lanceolatus-%C3%A2
#12
JOURNAL ARTICLE
Nurhikmah Abu Aziz, Annie Christianus, Wan Mohd Syazwan Wan Solahudin, Intan Safinar Ismail, Chen-Fei Low
Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non-haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio-resistant and Vibrio-susceptible grouper. Samples were analysed using high-throughput LC-MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up-regulated in the resistant group compared to the control and the susceptible groups...
March 24, 2024: Journal of Fish Diseases
https://read.qxmd.com/read/38521836/associations-between-lipid-abnormalities-and-diabetic-retinopathy-across-a-large-united-states-national-database
#13
JOURNAL ARTICLE
Hejin Jeong, Christopher M Maatouk, Matthew W Russell, Rishi P Singh
BACKGROUND/OBJECTIVES: While dyslipidaemia has been suggested as a potential risk factor for diabetic retinopathy (DR), previous studies have reported conflicting findings. This study aimed to better characterize the relationship between abnormal serum levels of various lipid markers and the risk of the development and progression of DR. SUBJECTS/METHODS: This retrospective cohort study utilized a United States national database of electronic medical records. Adults with a history of type 2 diabetes mellitus without type 1 diabetes mellitus were divided into cohorts based on the presence of abnormal serum levels of various lipid markers...
March 23, 2024: Eye
https://read.qxmd.com/read/38521514/pyomyoma-after-caesarean-section-a-rare-entity
#14
JOURNAL ARTICLE
Sujata Siwatch, Rashmi Bagga, Tulika Singh, Gaurav Khastgir
Pyomyoma, a rare complication of a myoma undergoing infarction and subsequent infection, may be a diagnostic challenge in patients with unexplained puerperal fever. A woman in her 30s presented with fever and foul-smelling discharge per vaginum, 6 months after her first caesarean section (CS). She underwent an elective CS for symptomatic placenta praevia at 34 weeks of gestation. Intra-operatively, post-partum haemorrhage was managed with uterotonics and blood transfusions. However, 2 weeks later, she developed a high-grade fever that was non-responsive to parenteral antibiotics...
March 22, 2024: BMJ Case Reports
https://read.qxmd.com/read/38521407/clinical-and-biological-factors-associated-with-red-blood-cell-transfusion-during-severe-postpartum-haemorrhage-a-single-center-retrospective-cohort-study
#15
JOURNAL ARTICLE
Lauren Cravassac, Rayan Hamadmad, Simon Crequit, Redel Diane, Yakhou Leila, Verton Caroline, Bassam Haddad, Edouard Lecarpentier
INTRODUCTION: red blood cell (RBC) transfusions are of utmost importance in the management of severe post-partum haemorrhage. Although the recommendations for blood transfusion protocols are regularly issued, there are significant differences in management depending on the context and the medical teams involved. OBJECTIVE: to determine during the first 24 hours, the clinical and biological factors associated with the decision for RBC transfusion during severe PPH (≥1000 mL) for vaginal and caesarean deliveries...
March 21, 2024: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/38519911/the-effect-of-pregnancy-on-renal-angiomyolipoma-a-world-of-knowledge-to-gain-specifically-in-women-with-tsc
#16
JOURNAL ARTICLE
Marlou W Kluiving, Evelien F H I Peeters, Titia A Lely, Niek van Oorschot, Wendela L de Ranitz-Greven
BACKGROUND: Women are counseled preconceptionally about the potential risks of rAML progression and chance of complications during and due to pregnancy. However, a systematic search investigating the evidence on which this advice is based does not exist. The aim of this systematic review is to determine the effect of pregnancy on renal angiomyolipoma (rAML) size and risk of haemorrhage in patients with tuberous sclerosis complex (TSC). METHODS: We searched PubMed, EMBASE, Medline and ClinicalTrials...
March 22, 2024: BMC Nephrology
https://read.qxmd.com/read/38519847/intrarectal-formalin-treatment-for-haemorrhagic-radiation-induced-proctopathy-efficacy-and-safety
#17
JOURNAL ARTICLE
Darina Kohoutova, Ana Wilson, Caroline Gee, Ramy Elhusseiny, Linda Wanders, David Cunningham
AIM: Pelvic radiotherapy is limited by dose-dependent toxicity to surrounding organs. The aim of this prospective study was to evaluate the efficacy and safety of intrarectal formalin treatment for radiotherapy-induced haemorrhagic proctopathy (RHP) at the Royal Marsden Hospital. METHOD: Adult patients were enrolled. Haemoglobin was evaluated before and after formalin treatment. Antiplatelet and/or anticoagulation treatment and administration of transfusion were recorded...
March 22, 2024: Colorectal Disease
https://read.qxmd.com/read/38519843/evaluation-of-the-immune-response-of-layer-chickens-to-newcastle-disease-virus-vaccines-using-the-new-vaccination-regimens
#18
JOURNAL ARTICLE
Abel Sorsa Geletu, Dereje Tulu Robi
BACKGROUND: The study aimed to evaluate the immunological response of layer chickens to live Newcastle disease virus vaccine using a newly developed vaccine schedule administered via the ocular route, as well as assess the persistence of passive antibodies in layer chickens and the effectiveness of protection against strains of the virus. METHODS: A total of 140-day-old Lohmann Brown chicks were randomly divided into seven groups, 20 chicks each. Groups 1-3 received a single eye instillation of the vaccine at ages 5, 26 and 54 days, respectively, whereas groups 4-6 received a double eye instillation...
May 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38518844/comparative-efficacy-and-safety-of-mitral-valve-repair-versus-mitral-valve-replacement-in-improving-clinical-outcomes-in-patients-with-rhematic-heart-disease-a-high-value-care-systematic-review-and-meta-analysis
#19
REVIEW
Farah Yasmin, Abdul Moeed, Hala Najeeb, Muhammad Umar, Shizra Jawed, Abdul Raafe Atif, Muhammad Sohaib Asghar, M Chadi Alraies
Rheumatic Heart Disease (RHD) remains a leading cause of cardiovascular death (CVD) globally. Mitral Valve repair (MVP) and mitral valve replacement (MVR) are the two most commonly and successfully used techniques to treat the disease. MVP is associated with reduced post-operative complications compared to MVR; however, it carries the risk of valvular fibrosis and scarring. Given the lack of recommendations, inconsistent findings, and paucity of pathophysiological evidence at present, we aimed to conduct a meta-analysis and systematically review the available literature to determine the efficacy and safety of MVP compared to MVR in improving clinical outcomes among patients with RHD...
March 20, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38517643/impact-of-healthcare-associated-infections-within-7-days-of-acute-stroke-on-health-outcomes-and-risk-of-care-dependency-a-multi-centre-registry-based-cohort-study
#20
JOURNAL ARTICLE
David Fluck, Christopher H Fry, Jonathan Robin, Brendan Affley, Puneet Kakar, Pankaj Sharma, Thang S Han
Healthcare-associated infections (HCAIs) in patients admitted with acute conditions remain a major challenge to healthcare services. Here, we assessed the impact of HCAIs acquired within 7-days of acute stroke on indicators of care-quality outcomes and dependency. Data were prospectively collected (2014-2016) from the Sentinel Stroke National Audit Programme for 3309 patients (mean age = 76.2 yr, SD = 13.5) admitted to four UK hyperacute stroke units (HASU). Associations between variables were assessed by multivariable logistic regression (odds ratios, 95% confidence intervals), adjusted for age, sex, co-morbidities, pre-stroke disability, swallow screening, stroke type and severity...
March 22, 2024: Internal and Emergency Medicine
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