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https://www.readbyqxmd.com/read/28543354/genotype-phenotype-relationship-in-mucopolysaccharidosis-ii-predictive-power-of-ids-variants-for-the-neuronopathic-phenotype
#1
Audrey A M Vollebregt, Marianne Hoogeveen-Westerveld, Marian A Kroos, Esmee Oussoren, Iris Plug, George J Ruijter, Ans T van der Ploeg, W W M Pim Pijnappel
AIM: Mucopolysaccharidosis type II (MPS II) is caused by variants in the iduronate-2-sulphatase gene (IDS). Patients can be either neuronopathic with intellectual disability, or non-neuronopathic. Few studies have reported on the IDS genotype-phenotype relationship and on the molecular effects involved. We addressed this in a cohort study of Dutch patients with MPS II. METHOD: Intellectual performance was assessed for school performance, behaviour, and intelligence...
May 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28542600/snp-in-human-arhgef3-promoter-is-associated-with-dnase-hypersensitivity-transcript-level-and-platelet-function-and-arhgef3-ko-mice-have-increased-mean-platelet-volume
#2
Siying Zou, Alexandra M Teixeira, Myrto Kostadima, William J Astle, Aparna Radhakrishnan, Lukas Mikolaj Simon, Lucy Truman, Jennifer S Fang, John Hwa, Ping-Xia Zhang, Pim van der Harst, Paul F Bray, Willem H Ouwehand, Mattia Frontini, Diane S Krause
Genome-wide association studies have identified a genetic variant at 3p14.3 (SNP rs1354034) that strongly associates with platelet number and mean platelet volume in humans. While originally proposed to be intronic, analysis of mRNA expression in primary human hematopoietic subpopulations reveals that this SNP is located directly upstream of the predominantly expressed ARHGEF3 isoform in megakaryocytes (MK). We found that ARHGEF3, which encodes a Rho guanine exchange factor, is dramatically upregulated during both human and murine MK maturation...
2017: PloS One
https://www.readbyqxmd.com/read/28542106/the-association-between-self-reported-low-back-pain-and-radiographic-lumbar-disc-degeneration-of-the-cohort-hip-and-cohort-knee-check-study
#3
Roxanne van den Berg, Lisa M Jongbloed, Natalia O Kuchuk, Leo D Roorda, J C M Oostveen, Bart W Koes, Edwin H G Oei, Sita M A Bierma-Zeinstra, Pim A J Luijsterburg
STUDY DESIGN: Cross-sectional study, nested in a prospective cohort (Cohort Hip and Knee, CHECK). OBJECTIVE: Low back pain (LBP) is very common and the main cause of activity limitations and work absence throughout the world. Although lumbar disc degeneration (LDD) is suggested as a cause of LBP, this association remains debatable. Therefore, this study assessed the association between the radiographic features of LDD and the presence of self-reported LBP, LBP persisting longer than three months, the perceived severity of LBP and presence of neuropathic pain...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28541273/nonlinear-mechanics-of-hybrid-polymer-networks-that-mimic-the-complex-mechanical-environment-of-cells
#4
Maarten Jaspers, Sarah L Vaessen, Pim van Schayik, Dion Voerman, Alan E Rowan, Paul H J Kouwer
The mechanical properties of cells and the extracellular environment they reside in are governed by a complex interplay of biopolymers. These biopolymers, which possess a wide range of stiffnesses, self-assemble into fibrous composite networks such as the cytoskeleton and extracellular matrix. They interact with each other both physically and chemically to create a highly responsive and adaptive mechanical environment that stiffens when stressed or strained. Here we show that hybrid networks of a synthetic mimic of biological networks and either stiff, flexible and semi-flexible components, even very low concentrations of these added components, strongly affect the network stiffness and/or its strain-responsive character...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28540648/impact-of-2015-update-to-the-beers-criteria-on-estimates-of-prevalence-and-costs-associated-with-potentially-inappropriate-use-of-antimuscarinics-for-overactive-bladder
#5
Brandon T Suehs, Cralen Davis, Daniel B Ng, Katherine Gooch
BACKGROUND: Research has demonstrated that the use of potentially inappropriate medication (PIM) is highly prevalent among older individuals and may lead to increased healthcare costs, adverse drug reactions, hospitalizations, and mortality. OBJECTIVES: The purpose of this study was to examine the impact of the 2015 updates to the Beers Criteria on estimates of prevalence and cost associated with potentially inappropriate use of antimuscarinic medications indicated for treatment of overactive bladder (OAB)...
May 24, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28540318/retromalleolar-groove-deepening-in-recurrent-peroneal-tendon-dislocation-technique-tip
#6
Pim A D van Dijk, Bryan G Vopat, Daniel Guss, Alastair Younger, Christopher W DiGiovanni
Peroneal tendon dislocations are most prevalent in the active and athletic population, so accurate diagnosis and management are essential for optimal return of function. Although many nonoperative and surgical management options have been described, the optimal treatment method continues to be debated. In this technique article, a modified retromalleolar groove-deepening technique is described for addressing all anatomic variations of the posterior distal fibula and retromalleolar groove without unduly disturbing the important anatomic facets meant for retention in this region...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28539202/detection-of-residual-head-and-neck-squamous-cell-carcinoma-after-chemo-radiotherapy-a-pilot-study-assessing-the-value-of-diffusion-weighted-magnetic-resonance-imaging-as-an-adjunct-to-pet-ct-using-18-f-fdg
#7
Daniel P Noij, Viresh A Jagesar, Pim de Graaf, Marcus C de Jong, Otto S Hoekstra, Remco de Bree, Jonas A Castelijns
OBJECTIVE: Diagnosing residual malignancy after (chemo)radiotherapy presents a diagnostic challenge because of overlapping symptoms and imaging characteristics. We assessed the added diagnostic value of diffusion-weighted imaging (DWI) to positron emission tomography combined with computed tomography (PET-CT) in patients with head and neck squamous cell carcinoma (HNSCC) with residual fluorodeoxyglucose ((18)F-FDG) uptake at the primary tumor site 3 months after (chemo)radiotherapy. STUDY DESIGN: For this retrospective study from January 2010 to June 2012, 22 cases (median patient age of 61 years; range 41-77 years) were included for analysis...
May 3, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28532439/efficacy-cost-utility-and-reach-of-an-ehealth-self-management-application-oncokompas-that-helps-cancer-survivors-to-obtain-optimal-supportive-care-study-protocol-for-a-randomised-controlled-trial
#8
Anja van der Hout, Cornelia F van Uden-Kraan, Birgit I Witte, Veerle M H Coupé, Femke Jansen, C René Leemans, Pim Cuijpers, Lonneke V van de Poll-Franse, Irma M Verdonck-de Leeuw
BACKGROUND: Cancer survivors have to deal with a wide range of physical symptoms, psychological, social and existential concerns, and lifestyle issues related to cancer and its treatment. Therefore, it is essential that they have access to optimal supportive care services. The eHealth self-management application Oncokompas was developed to support cancer survivors with where they need to turn to for advice and guidance, as well as to increase their knowledge on the availability of optimal support...
May 22, 2017: Trials
https://www.readbyqxmd.com/read/28529088/pilot-test-of-a-home-based-program-to-prevent-perceived-insufficient-milk
#9
Natsuko K Wood, Elizabeth A Sanders, Frances M Lewis, Nancy F Woods, Susan T Blackburn
PROBLEM: Although the World Health Organization and American Academy of Pediatrics recommend exclusive breastfeeding for the first six months, only 22% of U.S. mothers do so. Mothers' perceived insufficient milk (PIM) is the primary reason for breastfeeding discontinuation globally. There are two changeable causes of PIM: (1) mothers' misinterpretation of their infant's behavior, and (2) mothers' lack of confidence in their ability to breastfeed. AIM: The purpose of this study was to evaluate the short-term effect of a home-based intervention designed to prevent and/or reduce PIM...
May 18, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28526882/prediction-of-cognitive-and-motor-outcome-of-preterm-infants-based-on-automatic-quantitative-descriptors-from-neonatal-mr-brain-images
#10
Pim Moeskops, Ivana Išgum, Kristin Keunen, Nathalie H P Claessens, Ingrid C van Haastert, Floris Groenendaal, Linda S de Vries, Max A Viergever, Manon J N L Benders
This study investigates the predictive ability of automatic quantitative brain MRI descriptors for the identification of infants with low cognitive and/or motor outcome at 2-3 years chronological age. MR brain images of 173 patients were acquired at 30 weeks postmenstrual age (PMA) (n = 86) and 40 weeks PMA (n = 153) between 2008 and 2013. Eight tissue volumes and measures of cortical morphology were automatically computed. A support vector machine classifier was employed to identify infants who exhibit low cognitive and/or motor outcome (<85) at 2-3 years chronological age as assessed by the Bayley scales...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523101/design-and-synthesis-of-potent-and-selective-pim-kinase-inhibitors-by-targeting-unique-structure-of-atp-binding-pocket
#11
Hirofumi Nakano, Tsukasa Hasegawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano
In the development of kinase inhibitors, one of the major concerns is selectivity. An effective strategy to achieve high selectivity is to utilize structural differences among kinases to inform inhibitor design. Here, we set out to improve the PIM (proviral integration site for Moloney murine leukemia virus) kinase-inhibitory selectivity of our previously reported 7-azaindole derivative 2, which has promising ADMET properties, by targeting a unique bulge in the ATP-binding pocket. 6-Substituted 7-azaindoles, especially the 6-chlorinated derivatives, proved to be potent and selective PIM kinase inhibitors and appear to be promising lead compounds for future drug discovery...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28510303/cucurbit-8-uril-and-14-3-3-based-binary-bivalent-supramolecular-protein-assembly-platform-and-co-crystal-structure
#12
Pim de Vink, Jeroen Briels, Thomas Schrader, Lech Milroy, Luc Brunsveld, Christian Ottmann
Interactions between proteins frequently employ recognition sequences that engage in multivalent binding events. Dimeric 14-3-3 adapter proteins represent a prominent example, typically binding partner proteins in a phosphorylation-dependent mono- or bivalent manner. Here we describe the development of a cucurbit[8]uril (Q8)-based supramolecular system, which in conjunction with the 14-3-3 protein dimer acts as a binary and bivalent protein assembly platform. We fused the phenylalanine-glycine-glycine (FGG) tripeptide motif to the N-terminus of the 14-3-3-binding epitope of the estrogen receptor α (ERα), for selective binding to Q8...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28509727/lower-dementia-risk-with-different-classes-of-antihypertensive-medication-in-older-patients
#13
Tessa van Middelaar, Lonneke A van Vught, Eric P Moll van Charante, Lisa S M Eurelings, Suzanne A Ligthart, Jan W van Dalen, Bert Jan H van den Born, Edo Richard, Pim W A van Gool
OBJECTIVE: Use of antihypertensive medication (AHM) is potentially associated with a reduced risk of dementia. Both calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs) are suggested to have a more pronounced protective effect. We aimed to study the association between different classes of AHM and dementia in older people. METHODS: A subgroup of community-dwelling older people using AHM included in the 'Prevention of Dementia by Intensive Vascular Care' randomized controlled trial was studied...
May 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28507759/emerging-local-ablative-therapies-for-unresectable-perihilar-cholangiocarinoma-time-for-re-appraisal
#14
Pim B Olthof, Robert J Coelen, Michal Heger, Heinz-Josef Klümpen, Erik A Rauws, Thomas M van Gulik
No abstract text is available yet for this article.
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28507700/stepwise-observation-and-quantification-and-mixed-matrix-membrane-separation-of-co2-within-a-hydroxy-decorated-porous-host
#15
Christopher G Morris, Nicholas M Jacques, Harry G W Godfrey, Tamoghna Mitra, Detlev Fritsch, Zhenzhong Lu, Claire A Murray, Jonathan Potter, Tom M Cobb, Fajin Yuan, Chiu C Tang, Sihai Yang, Martin Schröder
The identification of preferred binding domains within a host structure provides important insights into the function of materials. State-of-the-art reports mostly focus on crystallographic studies of empty and single component guest-loaded host structures to determine the location of guests. However, measurements of material properties (e.g., adsorption and breakthrough of substrates) are usually performed for a wide range of pressure (guest coverage) and/or using multi-component gas mixtures. Here we report the development of a multifunctional gas dosing system for use in X-ray powder diffraction studies on Beamline I11 at Diamond Light Source...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28506569/-identifying-potentially-inappropriate-prescriptions-in-patients-over-65-years-old-using-original-beers-criteria-and-their-spanish-adaptation
#16
Josep Pastor Cano, Ana Aranda García, Juan José Gascón Cánovas, José Francisco Sánchez Ruiz, Víctor José Rausell Rausell, Mariana Tobaruela Soto
OBJECTIVE: To compare the detection of potentially inappropriate medication (PIM) using the original Beers criteria, a global reference for evaluating prescriptions in the elderly, and their Spanish version. DESIGN: Retrospective observational study LOCATION: A Primary Care area in the province of Murcia, Spain. PARTICIPANTS: A total of 7,856 subjects aged 65 and over, with at least one drug prescribed in a Primary Care Area of Spain during study period...
May 13, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28504859/anxiety-there-is-an-app-for-that-a-systematic-review-of-anxiety-apps
#17
REVIEW
Madalina Sucala, Pim Cuijpers, Frederick Muench, Roxana Cardoș, Radu Soflau, Anca Dobrean, Patriciu Achimas-Cadariu, Daniel David
BACKGROUND: Smartphones and mobile devices have become ubiquitous, and with the rapid advance of technology, the number of health applications (apps) that are available for consumers on these devices is constantly growing. In particular, there has been a recent proliferation of anxiety apps. However, there has been no review of the quality or content of these anxiety apps and little is known about their purpose, the features they contain, and their empirical support. The goal of this systematic review was to assess the commercially available anxiety apps...
May 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28497096/patient-complaints-emphasize-non-technical-aspects-of-care-at-a-tertiary-referral-hospital
#18
John D King, Pim A D van Dijk, Celeste L Overbeek, Michiel G J S Hageman, David Ring
BACKGROUND: Patient concerns represent opportunities for improvement in orthopaedic care. This study's objective is to identify the nature and prevalence of unsolicited patient complaints regarding orthopaedic care at a tertiary referral hospital. The primary null hypothesis that there are no demographic factors associated with complaint types was tested. Secondarily we determined if the overall complaint number and types differed by year. METHODS: Complaints to the hospital ombudsperson by orthopaedic patients between January 1997 and June 2013 were reviewed...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28496072/improvement-of-chromium-vi-extraction-from-acidic-solutions-using-a-poly-vinyl-chloride-based-polymer-inclusion-membrane-with-aliquat-336-as-the-carrier
#19
Shigehiro Kagaya, Tomonori Maeno, Kazuma Ito, Makoto Gemmei-Ide, Robert W Cattrall, Spas D Kolev
An important reason for the inefficient extraction of Cr(VI) from its acidic solutions into polymer inclusion membranes (PIMs), consisting of poly(vinyl chloride) as the base-polymer and Aliquat 336 as the carrier, was found to be associated with the leaching of Aliquat 336 from the PIMs into the solutions, where it subsequently reduced the anionic Cr(VI) species to cationic Cr(III) species. The PIM extraction efficiency for Cr(VI) was significantly improved by the addition of NaNO3 to the solutions, which suppressed the leaching of Aliquat 336 and the reduction of Cr(VI) to Cr(III)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28495388/recognizing-and-differentiating-uncommon-body-fluids-considerations-and-tools-for-a-proper-practical-approach
#20
REVIEW
Pim M W Janssens
Clinical laboratories are regularly requested to inspect uncommon body fluids obtained from patients because clinicians are uncertain as to the origin of the collected material. They may need this information for the actual diagnosis, to confirm a supposition, or for guiding treatment and invasive operations like draining and puncturing. Often there is also a need to know more precisely what is going on in the cavity that gave rise to the fluid, for instance a local infection or metastasis, or whether the cavity is connected to organs or fluid compartments nearby etcetera...
May 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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