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https://www.readbyqxmd.com/read/29227997/normalized-emphysema-scores-on-low-dose-ct-validation-as-an-imaging-biomarker-for-mortality
#1
Leticia Gallardo-Estrella, Esther Pompe, Pim A de Jong, Colin Jacobs, Eva M van Rikxoort, Mathias Prokop, Clara I Sánchez, Bram van Ginneken
The purpose of this study is to develop a computed tomography (CT) biomarker of emphysema that is robust across reconstruction settings, and evaluate its ability to predict mortality in patients at high risk for lung cancer. Data included baseline CT scans acquired between August 2002 and April 2004 from 1737 deceased subjects and 5740 surviving controls taken from the National Lung Screening Trial. Emphysema scores were computed in the original scans (origES) and after applying resampling, normalization and bullae analysis (normES)...
2017: PloS One
https://www.readbyqxmd.com/read/29226491/predictors-and-outcomes-of-heart-failure-with-mid-range-ejection-fraction
#2
Vijeta Bhambhani, Jorge R Kizer, Joao A C Lima, Pim van der Harst, Hossein Bahrami, Matthew Nayor, Christopher R de Filippi, Danielle Enserro, Michael J Blaha, Mary Cushman, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Frank P Brouwers, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Daniel Levy, David M Herrington, Wiek H van Gilst, Alain G Bertoni, Martin G Larson, Rudolf A de Boer, John S Gottdiener, Sanjiv J Shah, Jennifer E Ho
AIMS: While heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid-range ejection fraction (HFmrEF) remain unclear. We sought to examine clinical and biochemical predictors of incident HFmrEF in the community. METHODS AND RESULTS: We pooled data from four community-based longitudinal cohorts, with ascertainment of new heart failure (HF) classified into HFmrEF [ejection fraction (EF) 41-49%], HFpEF (EF ≥50%), and HFrEF (EF ≤40%)...
December 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29220759/polymer-inclusion-membrane-to-access-zn-speciation-comparison-with-root-uptake
#3
Ruben Vera, Clàudia Fontàs, Josep Galceran, Olga Serra, Enriqueta Anticó
Metal speciation studies can be performed with a new technique based on a functionalized membrane. The estimation of not only the total amount of metal, but also the metal available to living organisms is very important. In this context, we have investigated the use of a polymer inclusion membrane (PIM) in a new tool for the determination of free metal ion concentration. In order to check the usefulness of PIM devices in metal speciation studies and metal availability to potato plants (Solanum tuberosum), Zn has been chosen as a case study...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29219298/high-selective-red-emitting-fluorescent-probe-for-imaging-cancer-cells-in-situ-by-targeting-pim-1-kinase
#4
Shigang Guo, Jiangli Fan, Benhua Wang, Ming Xiao, Yueqing Li, Jianjun Du, Xiaojun Peng
Based on the fact that the enzyme-targeting probes were high sensitive and selective, a novel red-emitting probe (NB-BF) for Pim-1 kinase including three parts: fluorophore (NB), linker and inhibitor (BF), was designed for cancer optical imaging. In its free state, NB-BF was folded and the fluorescence was quenched by PET between fluorophore and inhibitor both in PBS buffer and normal cells. Significantly, it emitted strong red fluorescence in Pim-1 over-expressed cancer cells. The specificity of NB-BF for Pim-1 kinase was directly demonstrated by gene silencing analysis...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29216482/enantiomeric-profiling-of-chiral-illicit-drugs-in-a-pan-european-study
#5
Erika Castrignanò, Zhugen Yang, Richard Bade, Jose A Baz-Lomba, Sara Castiglioni, Ana Causanilles, Adrian Covaci, Emma Gracia-Lor, Felix Hernandez, Juliet Kinyua, Ann-Kathrin McCall, Alexander L N van Nuijs, Christoph Ort, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Yeonsuk Ryu, Kevin V Thomas, Pim de Voogt, Ettore Zuccato, Barbara Kasprzyk-Hordern
The aim of this paper is to present the first study on spatial and temporal variation in the enantiomeric profile of chiral drugs in eight European cities. Wastewater-based epidemiology (WBE) and enantioselective analysis were combined to evaluate trends in illicit drug use in the context of their consumption vs direct disposal as well as their synthetic production routes. Spatial variations in amphetamine loads were observed with higher use in Northern European cities. Enantioselective analysis showed a general enrichment of amphetamine with the R-(-)-enantiomer in wastewater indicating its abuse...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29215315/internet-based-vs-face-to-face-cognitive-behavior-therapy-for-psychiatric-and-somatic-disorders-an-updated-systematic-review-and-meta-analysis
#6
Per Carlbring, Gerhard Andersson, Pim Cuijpers, Heleen Riper, Erik Hedman-Lagerlöf
During the last two decades, Internet-delivered cognitive behavior therapy (ICBT) has been tested in hundreds of randomized controlled trials, often with promising results. However, the control groups were often waitlisted, care-as-usual or attention control. Hence, little is known about the relative efficacy of ICBT as compared to face-to-face cognitive behavior therapy (CBT). In the present systematic review and meta-analysis, which included 1418 participants, guided ICBT for psychiatric and somatic conditions were directly compared to face-to-face CBT within the same trial...
December 7, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29212778/the-identification-of-64-novel-genetic-loci-provides-an-expanded-view-on-the-genetic-architecture-of-coronary-artery-disease
#7
Pim van der Harst, Niek Verweij
Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. 97 genetic risk loci have been identified so far, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study (GWAS) in 34,541 CAD cases and 261,984 controls of UK biobank Resource followed by replication in 88,192 cases and 162,544 controls from CARDIoGRAMplusC4D...
December 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/29207322/identification-of-a-vte-rich-population-in-pediatrics-critically-ill-children-with-central-venous-catheters
#8
Minh Tran, Steven L Shein, Xinge Ji, Sanjay P Ahuja
BACKGROUND: The incidence of venous thromboembolism (VTE) is rising among inpatients in US hospitals, especially among kids with central venous catheters (CVCs) in the pediatric intensive care unit (PICU). OBJECTIVES: To identify a sub-group of "VTE-rich" population among PICU children, and to assess the effect of VTE on morbidity and mortality. METHODS: Data was extracted from a multicenter Virtual PICU Database, or VPS, for children with a CVC and presence of a VTE...
November 22, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29203797/the-interfacial-nature-of-proximity-induced-magnetism-and-the-dzyaloshinskii-moriya-interaction-at-the-pt-co-interface
#9
R M Rowan-Robinson, A A Stashkevich, Y Roussigné, M Belmeguenai, S-M Chérif, A Thiaville, T P A Hase, A T Hindmarch, D Atkinson
The Dzyaloshinskii-Moriya interaction has been shown to stabilise Nèel domain walls in magnetic thin films, allowing high domain wall velocities driven by spin current effects. The interfacial Dzyaloshinskii-Moriya interaction (IDMI) occurs at the interface between ferromagnetic and heavy metal layers with strong spin-orbit coupling, but details of the interaction remain to be understood and the role of proximity induced magnetism (PIM) in the heavy metal is unknown. Here IDMI and PIM are reported in Pt determined as a function of Au and Ir spacer layers in Pt/Co/Au,Ir/Pt...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200017/efficacy-of-eight-different-drug-treatments-for-patients-with-trigeminal-neuralgia-a-network-meta-analysis
#10
Fang Yang, Qiang Lin, Lihua Dong, Xiaohui Gao, Su'e Zhang
OBJECTIVES: Frequent trigeminal neuralgia (TN) is commonly seen in older persons and negatively influences a patient's daily life. Although some research on the efficacy of TN drugs has been conducted in the past, the optimal choice still remains uncertain. Therefore, this network meta-analysis evaluates the efficacy and performance of eight drugs with respect to TN. METHODS: All literature was retrieved from the PubMed and Embase electronic databases by jointly searching key terms...
December 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29199905/potentially-inappropriate-medication-in-primary-care-at-the-end-of-life-a-mixed-method-study
#11
Peter Pype, Fien Mertens, Fleur Helewaut, Bert D'Hulster, An De Sutter
CONTEXT: Polypharmacy results in adverse drug interactions, high pill burden, and medication costs. Stopping or diminishing potentially inappropriate medication (PIM), is complex . Data on the use of PIM in a primary care context are scarce and deprescribing barriers for general practitioners (GP) are underexplored. OBJECTIVE: Describing the use of PIM in primary care at the end of life, and exploring the barriers for GPs to deprescribe. METHODS: Retrospective chart review of 210 consecutive patients referred to a palliative home care service and semi-structured interviews with 11 GPs...
December 4, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29199218/uses-of-cyclohexan-1-4-dione-for-the-synthesis-of-2-amino-4-5-dihydrobenzo-b-thiophen-6-7h-one-derivatives-with-anti-proliferative-and-pim-1-kinase-activities
#12
Rafat Milad Mohareb, Nermeen Saeed Abbas, Rehab Ali Ibrahim
The reaction of cyclohexan-1,4-dione with elemental sulfur and any of the 2-cyano-N-arylacetamide derivatives 2a-c gave the 2-amino-4,5-dihydrobenzo[b]thiophen-6(7H)-one derivatives 3a-c to be used in some heterocyclization reactions. The multicomponent reactions of any of compounds 3a-c with aromatic aldehydes 6a-c and either of malononitrile or ethylcyanoacetate gave the 5,9-dihydro-4H-thieno[2,3-f]chromene derivatives 9a-r, respectively. The anti-proliferative evaluation of the newly synthesized compounds against the six cancer cell lines A549, HT-29, MKN-45, U87MG, SMMC-7721 and H460 showed that the nine compounds 3c, 5c, 9e, 9h, 9i, 9j, 9l, 9q, 11e and 13e with highest cytotoxcity...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29196240/the-pathophysiology-of-human-obstructive-cholestasis-is-mimicked-in-cholestatic-gold-syrian-hamsters
#13
Rowan F van Golen, Pim B Olthof, Lianne R de Haan, Robert-Jan Coelen, Alexandros Pechlivanis, Mark J de Keijzer, Ruud Weijer, Dirk R de Waart, André B P van Kuilenburg, Jeroen Roelofsen, Pim W Gilijamse, Martinus A Maas, Matthew R Lewis, Jeremy K Nicholson, Joanne Verheij, Michal Heger
Obstructive cholestasis causes liver injury via accumulation of toxic bile acids (BAs). Therapeutic options for cholestatic liver disease are limited, partially because the available murine disease models lack translational value. Profiling of time-related changes following bile duct ligation (BDL) in Gold Syrian hamsters revealed a biochemical response similar to cholestatic patients in terms of BA pool composition, alterations in hepatocyte BA transport and signaling, and suppression of BA production. Hamsters tolerated cholestasis well for up to 28days and progressed relatively slowly to fibrotic liver injury...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29193569/9-4t-and-17-6t-mri-of-retinoblastoma-ex-vivo-evaluation-of-microstructural-anatomy-and-disease-extent-compared-with-histopathology
#14
Marcus C de Jong, Pim de Graaf, Petra J W Pouwels, Jan-Willem Beenakker, Robin W Jansen, Jeroen J G Geurts, Annette C Moll, Jonas A Castelijns, Paul van der Valk, Louise van der Weerd
BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making. PURPOSE: To demonstrate ultrahigh-field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology. STUDY TYPE: Prospective case series...
November 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29189385/portal-inflow-modulation-by-somatostatin-after-major-liver-resection-a-pilot-study
#15
Rami Rhaiem, Tullio Piardi, Mikael Chetboun, Patrick Pessaux, Thibaut Lestra, Riccardo Memeo, Reza Kianmanesh, Daniele Sommacale
: Major hepatectomy (MH) can lead to an increasing portal vein pressure (PVP) and to lesions of the hepatic parenchyma. Several reports have assessed the deleterious effect of a high posthepatectomy PVP on the postoperative course of MH. Thus, several surgical modalities of portal inflow modulation (PIM) have been described. As for pharmacological modalities, experimental studies showed a potential efficiency of Somatostatin to reduce PVP and flow. To our knowledge, no previous clinical reports of PIM using somatostatin are available...
November 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29185694/the-molecular-mechanism-of-substrate-recognition-and-catalysis-of-the-membrane-acyltransferase-pata-from-mycobacteria
#16
Montse Tersa, Lluís Raich, David Albesa-Jové, Beatriz Trastoy, Jacques Prandi, Martine Gilleron, Carme Rovira, Marcelo E Guerin
Glycolipids play a central role in a variety of important biological processes in all living organisms. PatA is a membrane acyltransferase involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), key structural elements and virulence factors of Mycobacterium tuberculosis. PatA catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of inositol in PIM1/PIM2. We report here the crystal structure of PatA in the presence of 6-O-palmitoyl-α-D-mannopyranoside, unraveling the acceptor binding mechanism...
November 29, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29179437/high-glucose-promotes-vascular-smooth-muscle-cell-proliferation-by-upregulating-proto-oncogene-serine-threonine-protein-kinase-pim-1-expression
#17
Keke Wang, Xiaojiang Deng, Zhihua Shen, Yanan Jia, Ranran Ding, Rujia Li, Xiaomin Liao, Sisi Wang, Yanping Ha, Yueqiong Kong, Yuyou Wu, Junli Guo, Wei Jie
Serine/threonine kinase proviral integration site for Moloney murine leukemia virus 1 (Pim-1) plays an essential role in arterial wall cell proliferation and associated vascular diseases, including pulmonary arterial hypertension and aortic wall neointima formation. Here we tested a role of Pim-1 in high-glucose (HG)-mediated vascular smooth muscle cell (VSMC) proliferation. Pim-1 and proliferating cell nuclear antigen (PCNA) expression levels in arterial samples from streptozotocin-induced hyperglycemia rats were increased, compared with their weak expression in normoglycemic groups...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29178511/neurostimulation-for-refractory-cervicogenic-headache-a-three-year-retrospective-study
#18
Marzieh Eghtesadi, Elizabeth Leroux, Marie-Pierre Fournier-Gosselin, Paul Lespérance, Luc Marchand, Heather Pim, Andreea Adelina Artenie, Line Beaudet, Guy Pierre Boudreau
BACKGROUND: Occipital nerve stimulation (ONS) has been used for the treatment of neuropathic pain conditions and could be a therapeutic approach for refractory cervicogenic headache (CeH). AIM: The aim of this study is to assess the efficacy and safety of unilateral ONS in patients suffering from refractory CeH. METHODS: We conducted a retrospective chart review on patients implanted from 2011 to 2013 at CHUM. The primary outcome was a 50% reduction in headache days per month...
November 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29177646/longitudinal-patterns-of-potentially-inappropriate-prescribing-in-early-old-aged-people
#19
Christina Raae Hansen, Stephen Byrne, Shane Cullinan, Denis O'Mahony, Laura J Sahm, Patricia M Kearney
PURPOSE: It is contentious whether potentially inappropriate prescribing (PIP) is predominantly a phenomenon of late life or whether it has its origins in early old age. This study examined the pattern of PIP in an early old-aged population over 5 years. METHODS: Secondary data analysis of a population-based primary care cohort, of patients aged 60-74 years. Medication data were extracted from electronic patient records in addition to information on comorbidities and demographics...
November 25, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29177579/disagreement-between-splenic-switch-off-and-myocardial-t1-mapping-after-caffeine-intake
#20
Dirkjan Kuijpers, Randy van Dijk, Marly van Assen, Theodorus A M Kaandorp, Paul R M van Dijkman, Rozemarijn Vliegenthart, Pim van der Harst, Matthijs Oudkerk
Caffeine is an adenosine receptor antagonist and a possible cause of inadequate stress perfusion. Splenic switch-off (SSO) and splenic rest-stress T1-mapping have been proposed as indicators of stress adequacy during perfusion cardiac magnetic resonance (CMR). We compared myocardial rest-stress T1-mapping with SSO and splenic rest-stress T1-mapping in patients with and without recent coffee intake. We analyzed 344 consecutive patients suspected of myocardial ischemia with adenosine perfusion CMR. All 146 normal CMR studies with a normal T1-rest of the myocardium, used as standard of reference, were included and divided in two groups...
November 24, 2017: International Journal of Cardiovascular Imaging
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