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https://www.readbyqxmd.com/read/28431341/eco-friendly-synthesis-of-novel-cyanopyridine-derivatives-and-their-anticancer-and-pim-1-kinase-inhibitory-activities
#1
Khaled A M Abouzid, Ghada H Al-Ansary, Abeer M El-Naggar
Targeting Pim-1 kinase recently proved to be profitable for conquering cancer proliferation. In the current study, we report the design, synthesis and biological evaluation of two novel series of 2-amino cyanopyridine series (5a-g) and 2-oxocyanopyridine series (6a-g) targeting Pim-1 kinase. All of the newly synthesized compounds were evaluated for their in vitro anticancer activity against a panel of three cell lines, namely, the liver cancer cell line (HepG2), the colon cancer cell line (HCT-116) and the breast cancer cell line (MCF-7)...
April 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28429634/migration-of-oligomers-from-pet-determination-of-diffusion-coefficients-and-comparison-of-experimental-versus-modelled-migration
#2
Maria Hoppe, Roberta Fornari, Pim de Voogt, Roland Franz
Polyethylene terephthalate is increasingly used as food contact material for example in containers for beverage such as bottles for soft drinks, mineral water, juices and beer. Mass transport of substances present in packaging materials into the packed food and beverages is monitored to verify the food law compliance of the materials. PET is known to contain or give rise to migrants that are oligomers derived from the polymeric material. Until now their actual migration potential has been investigated only poorly...
April 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28426480/the-hiba-index-for-alpps-preliminary-results-to-interpret-with-caution
#3
Pim B Olthof, Thomas M van Gulik, Roelof J Bennink
No abstract text is available yet for this article.
April 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28426190/robust-polymer-electrolyte-membranes-with-high-ambient-temperature-lithium-ion-conductivity-via-polymerization-induced-microphase-separation
#4
Sujay A Chopade, Jesus G Au, Ziang Li, Peter W Schmidt, Marc A Hillmyer, Timothy P Lodge
Mechanically robust polymer electrolyte membranes (PEMs) exhibiting high ionic conductivity at ambient temperature are a prerequisite for next-generation electrochemical devices. We utilized a polymerization-induced microphase separation (PIMS) strategy to prepare nanostructured materials comprising continuous conducting nanochannels intertwined with a mechanically and thermally robust cross-linked polymeric framework. Addition of succinonitrile (SN) rendered the poly(ethylene oxide)/lithium (Li) salt conducting domains completely amorphous, resulting in outstanding conductivities (∼0...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425234/alpha-1-antitrypsin-levels-and-polymorphisms-in-interstitial-lung-diseases
#5
Nalan Demir, Özlem Erçen Diken, Halil Gürhan Karabulut, Demet Karnak, Oya Kayacan
BACKGROUND/AIM: Alpha-1 antitrypsin deficiency may be a potential predisposing factor for interstitial lung fibrosis. We investigated alpha-1 antitrypsin levels and its polymorphisms in patients with interstitial lung disease. MATERIALS AND METHODS: A total of 103 interstitial lung disease patients were compared. RESULTS: The mean alpha-1 antitrypsin level in idiopathic interstitial pneumonia patients was 1.67 ± 0.33 g/L, and it was 1.54 ± 0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424361/computed-tomographic-findings-in-subjects-who-died-from-respiratory-disease-in-the-national-lung-screening-trial
#6
Esther Pompe, Pim A de Jong, David A Lynch, Nikolas Lessmann, Ivana Išgum, Bram van Ginneken, Jan-Willem J Lammers, Firdaus A A Mohamed Hoesein
We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28423857/the-association-between-the-stopp-start-criteria-and-gastro-intestinal-track-bleedings-in-elderly-patients
#7
Anouk Veldhuis, Danielle Sent, Linette Bruin-Huisman, Erna Beers, Ameen Abu-Hanna
Potentially inappropriate prescribing is a common problem, especially in elderly care. To tackle this problem, Irish medical experts have developed a list of criteria when medication should be added or omitted based upon the patient's physical condition and medication use, known as the STOPP and START criteria. The STOPP and START criteria have been formulated to identify the prescribing of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs). One of the most common problems of inappropriate prescribing is gastro-intestinal track bleedings...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423192/systematic-review-of-the-safety-and-efficacy-of-palivizumab-among-infants-and-young-children-with-cystic-fibrosis
#8
Kok Pim Kua, Shaun Wen Huey Lee
BACKGROUND: Respiratory syncytial virus (RSV) is a common pathogen in infants with cystic fibrosis (CF). The use of palivizumab prophylaxis for RSV infection as the standard of care for infants with CF remains controversial. OBJECTIVE: To evaluate the efficacy of palivizumab in reducing the incidence of RSV hospitalization in children with CF who are younger than 2 years of age. METHODS: Four electronic databases (PubMed, Embase, CINAHL, and CENTRAL) were searched from inception until January 31, 2017 for clinical studies investigating the use of palivizumab in infants with CF aged less than 2 years...
April 19, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28421030/cluster-analysis-to-identify-possible-subgroups-in-tinnitus-patients
#9
Minke J C van den Berge, Rolien H Free, Rosemarie Arnold, Emile de Kleine, Rutger Hofman, J Marc C van Dijk, Pim van Dijk
INTRODUCTION: In tinnitus treatment, there is a tendency to shift from a "one size fits all" to a more individual, patient-tailored approach. Insight in the heterogeneity of the tinnitus spectrum might improve the management of tinnitus patients in terms of choice of treatment and identification of patients with severe mental distress. The goal of this study was to identify subgroups in a large group of tinnitus patients. METHODS: Data were collected from patients with severe tinnitus complaints visiting our tertiary referral tinnitus care group at the University Medical Center Groningen...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28419203/selective-cutoff-reporting-in-studies-of-diagnostic-test-accuracy-a-comparison-of-conventional-and-individual-patient-data-meta-analyses-of-the-patient-health-questionnaire-9-depression-screening-tool
#10
Brooke Levis, Andrea Benedetti, Alexander W Levis, John P A Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A Kloda, Dean McMillan, Scott B Patten, Russell J Steele, Roy C Ziegelstein, Charles H Bombardier, Flavia de Lima Osório, Jesse R Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C P M van Weert, Mary A Whooley, Linda S Williams, Karin A Wittkampf, Albert S Yeung, Brett D Thombs
In studies of diagnostic test accuracy, authors sometimes report results only for a range of cutoff points around data-driven "optimal" cutoffs. We assessed selective cutoff reporting in studies of the diagnostic accuracy of the Patient Health Questionnaire-9 (PHQ-9) depression screening tool. We compared conventional meta-analysis of published results only with individual-patient-data meta-analysis of results derived from all cutoff points, using data from 13 of 16 studies published during 2004-2009 that were included in a published conventional meta-analysis...
April 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28415816/targeting-the-pim-protein-kinases-for-the-treatment-of-a-t-cell-acute-lymphoblastic-leukemia-subset
#11
Sathish K R Padi, Libia A Luevano, Ningfei An, Ritu Pandey, Neha Singh, Jin H Song, Jon C Aster, Xue-Zhong Yu, Shikhar Mehrotra, Andrew S Kraft
New approaches are needed for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission with chemotherapy. Analysis of the effects of pan-PIM protein kinase inhibitors on human T-ALL cell lines demonstrated that the sensitive cell lines expressed higher PIM1 protein kinase levels, whereas T-ALL cell lines with NOTCH mutations tended to have lower levels of PIM1 kinase and were insensitive to these inhibitors. NOTCH-mutant cells selected for resistance to gamma secretase inhibitors developed elevated PIM1 kinase levels and increased sensitivity to PIM inhibitors...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413737/amino-acid-leucine-chromatography-a-study-of-branched-chain-aminoaciduria-in-type-2-diabetes
#12
Bhagavan Reddy Kolanu, Venugopal Boddula, Sabitha Vadakedath, Venkataramana Kandi
INTRODUCTION: Diabetes is a disease characterized by insulin deficiency resulting in glucose intolerance and in abnormalities of other metabolic fuels including protein. Recently, a number of studies have revealed that branched-chain amino acids (BCAAs) (leucine, isoleucine, and valine) play an important role in the regulation of protein synthesis by activating mammalian target of rapamycin (mTOR) in pancreatic β cells. BCAAs have positive effects on the regulation of glucose homeostasis...
March 12, 2017: Curēus
https://www.readbyqxmd.com/read/28410386/radiation-dose-reduction-in-pediatric-great-vessel-stent-computed-tomography-using-iterative-reconstruction-a-phantom-study
#13
Annemarie M den Harder, Dominika Suchá, Pieter J van Doormaal, Ricardo P J Budde, Pim A de Jong, Arnold M R Schilham, Johannes M P J Breur, Tim Leiner
BACKGROUND: To study dose reduction using iterative reconstruction (IR) for pediatric great vessel stent computed tomography (CT). METHODS: Five different great vessel stents were separately placed in a gel-containing plastic holder within an anthropomorphic chest phantom. The stent lumen was filled with diluted contrast gel. CT acquisitions were performed at routine dose, 52% and 81% reduced dose and reconstructed with filtered back projection (FBP) and IR. Objective image quality in terms of noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) as well as subjective image quality were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28405697/potentially-inappropriate-medicines-in-elderly-hospitalised-patients-according-to-the-eu-7-pim-list-stopp-version-2-criteria-and-comprehensive-protocol
#14
Iva Mucalo, Maja Ortner Hadžiabdić, Andrea Brajković, Sonja Lukić, Patricia Marić, Ivana Marinović, Vesna Bačić-Vrca
PURPOSE: The aim of this study was to measure the prevalence of potentially inappropriate medications (PIMs) by using the EU(7)-PIM list, STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) version 2 criteria and the new comprehensive protocol. METHODS: This prospective study involved a sample of 276 consecutive elderly patients discharged from the university teaching hospital. Age, gender, diagnoses, medication history and medicines at discharge were recorded...
April 12, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28401901/missing-heritability-is-the-gap-closing-an-analysis-of-32-complex-traits-in-the-lifelines-cohort-study
#15
Ilja M Nolte, Peter J van der Most, Behrooz Z Alizadeh, Paul Iw de Bakker, H Marike Boezen, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Dirkje S Postma, Marianne G Rots, Ronald P Stolk, Morris A Swertz, Bruce Hr Wolffenbuttel, Cisca Wijmenga, Harold Snieder
Despite the recent explosive rise in number of genetic markers for complex disease traits identified in genome-wide association studies, there is still a large gap between the known heritability of these traits and the part explained by these markers. To gauge whether this 'heritability gap' is closing, we first identified genome-wide significant SNPs from the literature and performed replication analyses for 32 highly relevant traits from five broad disease areas in 13 436 subjects of the Lifelines Cohort...
April 12, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28401374/does-early-resection-of-presumed-low-grade-glioma-improve-survival-a-clinical-perspective
#16
Maarten M J Wijnenga, Tariq Mattni, Pim J French, Geert-Jan Rutten, Sieger Leenstra, Fred Kloet, Martin J B Taphoorn, Martin J van den Bent, Clemens M F Dirven, Marie-Lise van Veelen, Arnaud J P E Vincent
Early resection is standard of care for presumed low-grade gliomas. This is based on studies including only tumors that were post-surgically confirmed as low-grade glioma. Unfortunately this does not represent the clinicians' situation wherein he/she has to deal with a lesion on MRI that is suspect for low-grade glioma (i.e. without prior knowledge on the histological diagnosis). We therefore aimed to determine the optimal initial strategy for patients with a lesion suspect for low-grade glioma, but not histologically proven yet...
April 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28399836/cost-effectiveness-of-response-evaluation-after-chemoradiation-in-patients-with-advanced-oropharyngeal-cancer-using-18-f-fdg-pet-ct-and-or-diffusion-weighted-mri
#17
Marjolein Je Greuter, Charlotte S Schouten, Jonas A Castelijns, Pim de Graaf, Emile Fi Comans, Otto S Hoekstra, Remco de Bree, Veerle Mh Coupé
BACKGROUND: Considerable variation exists in diagnostic tests used for local response evaluation after chemoradiation in patients with advanced oropharyngeal cancer. The yield of invasive examination under general anesthesia (EUA) with biopsies in all patients is low and it may induce substantial morbidity. We explored four response evaluation strategies to detect local residual disease in terms of diagnostic accuracy and cost-effectiveness. METHODS: We built a decision-analytic model using trial data of forty-six patients and scientific literature...
April 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28399319/factors-associated-with-potentially-inappropriate-medication-use-in-rural-community-dwelling-older-adults
#18
Marcia Y Shade, Ann M Berger, Claudia Chaperon, Gleb Haynatzki, Linda Sobeski, Bernice Yates
Potentially inappropriate medication (PIM) use is a serious public health problem in older adults because it may lead to adverse events. The purpose of the current study was to explore PIM use in rural, community-dwelling older adults. Participants (N = 138) underwent one-on-one medication reviews. Approximately one half (49%) of the sample used prescribed and over-the-counter (OTC) PIM. Prescribed and OTC nonsteroidal anti-inflammatory drugs (33%) and anticholinergic medications (28%) were the most frequently used PIM...
April 11, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28392168/cognitive-and-behavioral-therapies-in-the-treatment-of-insomnia-a-meta-analysis
#19
REVIEW
Annemieke van Straten, Tanja van der Zweerde, Annet Kleiboer, Pim Cuijpers, Charles M Morin, Jaap Lancee
Insomnia is a major public health problem considering its high prevalence, impact on daily life, co-morbidity with other disorders and societal costs. Cognitive behavioral treatment for insomnia (CBTI) is currently considered to be the preferred treatment. However, no meta-analysis exists of all studies using at least one component of CBTI for insomnia, which also uses modern techniques to pool data and to analyze subgroups of patients. We included 87 randomized controlled trials, comparing 118 treatments (3724 patients) to non-treated controls (2579 patients)...
February 9, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28389968/predictors-of-left-ventricular-remodeling-after-st-elevation-myocardial-infarction
#20
Tom Hendriks, Minke H T Hartman, Pieter J J Vlaar, Niek H J Prakken, Yldau M Y van der Ende, Chris P H Lexis, Dirk J van Veldhuisen, Iwan C C van der Horst, Erik Lipsic, Robin Nijveldt, Pim van der Harst
Adverse left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is associated with morbidity and mortality. We studied clinical, biochemical and angiographic determinants of LV end diastolic volume index (LVEDVi), end systolic volume index (LVESVi) and mass index (LVMi) as global LV remodeling parameters 4 months after STEMI, as well as end diastolic wall thickness (EDWT) and end systolic wall thickness (ESWT) of the non-infarcted myocardium, as compensatory remote LV remodeling parameters...
April 7, 2017: International Journal of Cardiovascular Imaging
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