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https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#1
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29678798/analysis-of-college-students-personal-health-information-activities-online-survey
#2
Sujin Kim, Donghee Sinn, Sue Yeon Syn
BACKGROUND: With abundant personal health information at hand, individuals are faced with a critical challenge in evaluating the informational value of health care records to keep useful information and discard that which is determined useless. Young, healthy college students who were previously dependents of adult parents or caregivers are less likely to be concerned with disease management. Personal health information management (PHIM) is a special case of personal information management (PIM) that is associated with multiple interactions among varying stakeholders and systems...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29678071/ready-for-hit-innovations-developing-a-tool-to-assess-the-professionalism-of-information-management-in-hospitals
#3
Jan-David Liebe, Moritz Esdar, Franziska Jahn, Ursula Hübner
Current frameworks postulate the success of health IT innovations to be determined by the professionalism of the information management (PIM). Still, empirical knowledge about PIM is scarce up until today. This study seeks to answer three research questions: (1.) How can PIM be measured in a reliable and valid way, (2.) how pronounced is PIM in German hospitals and (3.) do hospital characteristics have an impact on the degree of PIM? Based on the results of an expert workshop and frameworks for information management (IM) items for a PIM inventory were developed and the inventory sent to 1349 chief information officers of German hospitals...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29674846/costs-of-medication-in-older-patients-before-and-after-comprehensive-geriatric-assessment
#4
Gulcin Done Unutmaz, Pinar Soysal, Busra Tuven, Ahmet Turan Isik
Background: Polypharmacy and inappropriate drug use cause numerous complications, such as cognitive impairment, frailty, falls, and functional dependence. The present study aimed to determine the effect of the comprehensive geriatric assessment (CGA) on polypharmacy, potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs), and to evaluate the economic reflections of medication changes. Methods: One thousand five hundred and seventy-nine older patients, who had undergone CGA, were retrospectively evaluated...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29673364/colorectal-dysplasia-and-adenocarcinoma-in-patients-with-ulcerative-colitis-an-experience-from-a-tertiary-care-hospital
#5
Naila Younus, Mariam Abid, Atif Ali Hashmi, Saher Aijaz, Muhammad Muzzammil Edhi, Ahmareen Khalid Sheikh, Amir Khan
BACKGROUND: The rationale behind this study was to find out the frequency of dysplasia and colorectal cancer (CRC) in young patients with ulcerative colitis (UC) using histopathological examination. This facilitated early detection of dysplasia and CRC by regular endoscopic biopsies and also guided physicians on appropriate surveillance and management, thus improved outcome. METHODS: It was a prospective cross-sectional study conducted at the Department of Pathology, PIMS, Islamabad...
April 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29670058/effective-conversion-of-amide-to-carboxylic-acid-on-polymers-of-intrinsic-microporosity-pim-1-with-nitrous-acid
#6
Wei-Hsuan Wu, Paul Thomas, Paul Hume, Jianyong Jin
Carboxylate-functionalised polymers of intrinsic microporosity (C-PIMs) are highly desirable materials for membrane separation applications. The recently reported method to afford C-PIMs was via an extensive base hydrolysis process requiring 360 h. Herein, a novel and effective method to convert PIM-CONH₂ to C-PIM using nitrous acid was studied. The chemical structure of C-PIM was characterised by ¹H NMR, 13 C NMR, FTIR, elemental analysis, UV-Vis, TGA and TGA-MS. Complete conversion from amide to carboxylic acid groups was confirmed...
April 18, 2018: Membranes
https://www.readbyqxmd.com/read/29670044/improving-color-accuracy-of-colorimetric-sensors
#7
Eric Kirchner, Pim Koeckhoven, Keshav Sivakumar
Accurate measurements of reflectance and color require spectrophotometers with prices often exceeding $3000. Recently, new “color instruments” became available with much lower prices, thanks to the availability of inexpensive colorimetric sensors. We investigated the Node+ChromaPro and the Color Muse, launched in 2015 and 2016 by Variable Inc. Both instruments are colorimeters, combining a colorimetric sensor with LED lighting. We investigated color accuracy compared to a high-end spectrophotometer from BYK Gardner...
April 18, 2018: Sensors
https://www.readbyqxmd.com/read/29667228/the-anterior-longitudinal-ligament-in-diffuse-idiopathic-skeletal-hyperostosis-ossified-or-displaced
#8
Jonneke S Kuperus, Esther Jm Smit, Behdad Pouran, Robbert W van Hamersvelt, Marijn van Stralen, Peter R Seevinck, Constantinus F Buckens, Ronald Law Bleys, Harrie H Weinans, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four human cadaveric spines diagnosed with DISH using CT imaging were frozen and sectioned using a cryomacrotome. Photographs were obtained of the specimen at 125µm intervals...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29665778/characteristics-of-elderly-patients-with-polypharmacy-who-refuse-to-participate-in-an-in-hospital-deprescribing-intervention-a-retrospective-cross-sectional-study
#9
Junpei Komagamine, Kenichi Sugawara, Kazuhiko Hagane
BACKGROUND: Few studies have evaluated the characteristics of elderly patients with polypharmacy refusing deprescribing. The aim of this study was to evaluate the prevalence of potentially inappropriate medication (PIM) use in elderly patients accepting and refusing a deprescribing intervention and to investigate factors associated with deprescribing refusal. METHODS: We conducted a retrospective cross-sectional study by analyzing the electronic medical records from a single hospital...
April 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29665636/formation-mechanism-of-secondary-organic-aerosol-from-ozonolysis-of-gasoline-vehicle-exhaust
#10
Bo Yang, Pengkun Ma, Jinian Shu, Peng Zhang, Jingyun Huang, Haixu Zhang
Gasoline vehicles are a major source of anthropogenic secondary organic aerosols (SOAs). However, current models based on known precursors fail to explain the substantial SOAs from vehicle emissions due to the inadequate understanding of the formation mechanism. To provide more information on this issue, the formation of SOAs from ozonolysis of four light-duty gasoline vehicle exhaust systems was investigated with a vacuum ultraviolet photoionization mass spectrometer (VUV-PIMS). Remarkable SOAs formation was observed and the SOAs were primarily aliphatic alkenes...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29665270/european-repository-of-explicit-criteria-of-potentially-inappropriate-medications-in-old-age
#11
Ivana Ivanova, Monique Elseviers, Maarten Wauters, Thierry Christiaens, Robert Vander Stichele
AIM: Lack of electronic assessment of medication lists in electronic health records is a barrier for more generalized use of potentially inappropriate medications (PIM) lists, designed for older adults. The aim was to construct a European repository of explicit criteria on PIM, suitable for electronic assessment. METHODS: PIM description, medication information, clinical information and level of evidence was entered. Criteria with unclear medication specifications were excluded...
April 17, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29665227/microenvironment-induced-pim-kinases-promote-cxcr4-triggered-mtor-pathway-required-for-chronic-lymphocytic-leukaemia-cell-migration
#12
Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska-Kania, Bartosz Puła, Hanna Makuch-Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech-Marańda, Bożena K Budziszewska, Maja Wasylecka-Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka, Przemysław Juszczyński
Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimulation, and coculture with stromal cells increases PIMs expression in CLL cells, indicating microenvironment-dependent PIMs regulation. PIM1 and PIM2 expression at diagnosis was higher in patients with advanced disease (Binet C vs...
April 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29664506/continuous-venovenous-hemofiltration-in-neonates-with-hyperammonemia-a-case-series
#13
Felipe Cavagnaro Santa María, Jorge Roque Espinosa, Pamela Guerra Hernández
INTRODUCTION: Neonatal hyperammonemia secondary due to inborn errors of metabolism is a rare condition with a high rate of neurological sequelae and mortality. Initial medical management is often insufficient to stop the progressive increase of ammonia, with the consequent deterioration of the patient. For this reason, depurative techniques have been implemented, including peritoneal dialysis, intermittent hemodialysis and continuous renal replacement therapy (CRRT). OBJECTIVE: To describe our experience with continuous extracorporeal dialysis in severely ill neonates with hyperammonemia...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664339/general-practitioners-referring-adults-to-mr-imaging-for-knee-pain-a-randomized-controlled-trial-to-assess-cost-effectiveness
#14
Kim van Oudenaarde, Nynke M Swart, Johan L Bloem, Sita M A Bierma-Zeinstra, Paul R Algra, Patrick J E Bindels, Bart W Koes, Rob G H H Nelissen, Jan A N Verhaar, Pim A J Luijsterburg, Monique Reijnierse, Wilbert B van den Hout
Purpose To determine the cost-effectiveness of early referral by the general practitioner for magnetic resonance (MR) imaging compared with usual care alone in patients aged 18-45 years with traumatic knee symptoms. Materials and Methods Cost-utility analysis was performed parallel to a prospective multicenter randomized controlled trial in Dutch general practice. A total of 356 patients with traumatic knee symptoms were included from November 2012 to December 2015 (mean age, 33 years ± 8 [standard deviation]; 222 men [62%])...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29663314/prediction-models-for-the-risk-of-spontaneous-preterm-birth-based-on-maternal-characteristics-a-systematic-review-and-independent-external-validation
#15
Linda Je Meertens, Pim van Montfort, Hubertina Cj Scheepers, Sander Mj van Kuijk, Robert Aardenburg, Josje Langenveld, Ivo Ma van Dooren, Iris M Zwaan, Marc Ea Spaanderman, Luc Jm Smits
INTRODUCTION: Prediction models may contribute to personalized risk-based management of women at high risk of spontaneous preterm delivery. Although prediction models are published frequently, often with promising results, external validation generally lacks. We performed a systematic review of prediction models for the risk of spontaneous preterm birth based on routine clinical parameters. Additionally, we externally validated and evaluated the clinical potential of the models. MATERIAL AND METHODS: Prediction models based on routinely collected maternal parameters obtainable during first 16 weeks of gestation were eligible for selection...
April 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29663172/individual-changes-in-neurocognitive-functioning-and-health-related-quality-of-life-in-patients-with-brain-oligometastases-treated-with-stereotactic-radiotherapy
#16
Pim B van der Meer, Esther J J Habets, Ruud G Wiggenraad, Antoinette Verbeek-de Kanter, Geert J Lycklama À Nijeholt, Hanneke Zwinkels, Martin Klein, Linda Dirven, Martin J B Taphoorn
BACKGROUND: Recently, it has been shown that at group level, patients with limited brain metastases treated with stereotactic radiotherapy (SRT) maintain their pre-treatment levels of neurocognitive functioning (NCF) and health-related quality of life (HRQoL). The aim of this study was to evaluate NCF and HRQoL changes over time at the individual patient level. METHODS: NCF (seven domains assessed with a standardized test battery) and HRQoL (eight predetermined scales assessed with the EORTC QLQ-C30 and BN20 questionnaires) were measured prior to SRT and at 3 and/or 6 months follow-up...
April 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29663171/prognostic-relevance-of-mutations-and-copy-number-alterations-assessed-with-targeted-next-generation-sequencing-in-idh-mutant-grade-ii-glioma
#17
Maarten M J Wijnenga, Pim J French, Hendrikus J Dubbink, Winand N M Dinjens, Peggy N Atmodimedjo, Johan M Kros, Ruth Fleischeuer, Clemens M F Dirven, Arnaud J P E Vincent, Martin J van den Bent
BACKGROUND: At current prognostication of low grade glioma remains suboptimal and might be improved with additional markers. These may guide treatment decisions, in particular on early adjuvant therapy versus wait and see after surgery. METHODS: We used a targeted Next-Generation Sequencing panel to assess mutational and copy number status of selected genes and chromosomes in a consecutive series of adult grade II supratentorial glioma, and assessed the impact of molecular markers of interest on overall survival...
April 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29658183/determining-the-accuracy-and-reliability-of-indirect-calorimeters-utilizing-the-methanol-combustion-technique
#18
Sepideh Kaviani, Dale A Schoeller, Eric Ravussin, Edward L Melanson, Sarah T Henes, Lara R Dugas, Ronald E Dechert, George Mitri, Paul F M Schoffelen, Pim Gubbels, Asa Tornberg, Stephen Garland, Marco Akkermans, Jamie A Cooper
BACKGROUND: Several indirect calorimetry (IC) instruments are commercially available, but comparative validity and reliability data are lacking. Existing data are limited by inconsistencies in protocols, subject characteristics, or single-instrument validation comparisons. The aim of this study was to compare accuracy and reliability of metabolic carts using methanol combustion as the cross-laboratory criterion. METHODS: Eight 20-minute methanol burn trials were completed on 12 metabolic carts...
April 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29657887/supramolecular-approaches-to-control-activity-and-selectivity-in-hydroformylation-catalysis
#19
REVIEW
Sandra S Nurttila, Pim R Linnebank, Tetiana Krachko, Joost N H Reek
The hydroformylation reaction is one of the most intensively explored reactions in the field of homogeneous transition metal catalysis, and many industrial applications are known. However, this atom economical reaction has not been used to its full potential, as many selectivity issues have not been solved. Traditionally, the selectivity is controlled by the ligand that is coordinated to the active metal center. Recently, supramolecular strategies have been demonstrated to provide powerful complementary tools to control activity and selectivity in hydroformylation reactions...
April 6, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29657149/the-natural-course-of-diffuse-idiopathic-skeletal-hyperostosis-in-the-thoracic-spine-of-adult-males
#20
Jonneke S Kuperus, Constantinus F Buckens, Jurica Šprem, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by flowing bony bridges on the right side of the spine. Knowledge of the development of these spinal bridges is limited. The current longitudinal computed tomography (CT) study was designed to bridge this gap. METHODS: Chest CT scans from elderly males with 2 scans (interval ≥ 2.5 yrs) were retrospectively included. Using the Resnick criteria, a pre-DISH group and a definite DISH group were identified...
April 15, 2018: Journal of Rheumatology
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