Read by QxMD icon Read


Sahu Ipshita, Ida G Kurian, Pankaj Dileep, Shatrughan Kumar, Priyanka Singh, Avani R Pradeep
AIM: Alendronate (ALN) has antiresorptive and osteostimulative properties. The major component of aloe vera (AV) gel is acemannan, which has been found to have osteogenic properties. The aim of the present study is to explore the effectiveness of 1% ALN and AV gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients with class II furcation defects. METHODS: Ninety volunteers were randomly assigned to three treatment groups: (a) SRP plus placebo gel; (b) SRP plus 1% ALN gel; and (c) SRP plus AV gel...
May 2, 2018: Journal of Investigative and Clinical Dentistry
Maria Paz Quezada, Carlos Salinas, Martin Gotteland, Liliana Cardemil
The nutraceutical properties of Aloe vera have been attributed to a glucomannan known as acemannan. Recently information has been published about the presence of fructans in Aloe vera but there are no publications about acemannan and fructans as prebiotic compounds. This study investigated in vitro the prebiotic properties of these polysaccharides. Our results demonstrated that fructans from Aloe vera induced bacterial growth better than inulin (commercial FOS). Acemannan stimulated bacterial growth less than fructans, and as much as commercial FOS...
November 22, 2017: Journal of Agricultural and Food Chemistry
Rafael Minjares-Fuentes, Víctor Manuel Rodríguez-González, Rubén Francisco González-Laredo, Valeria Eim, María Reyes González-Centeno, Antoni Femenia
The main effects of different drying procedures: spray-, industrial freeze-, refractance window- and radiant zone-drying, on acemannan, the main bioactive polysaccharide from Aloe vera gel, were investigated. All the drying procedures caused a considerable decrease in the acemannan yield (∼40%). Degradation affected not only the backbone, as indicated by the important losses of (1→4)-linked mannose units, but also the side-chains formed by galactose. In addition, methylation analysis suggested the deacetylation of mannose units (>60%), which was confirmed by1 H NMR analysis...
July 15, 2017: Carbohydrate Polymers
Carlos Salinas, Michael Handford, Markus Pauly, Paul Dupree, Liliana Cardemil
Aloe barbadensis Miller (Aloe vera) has a Crassulaceae acid metabolism which grants the plant great tolerance to water restrictions. Carbohydrates such as acemannans and fructans are among the molecules responsible for tolerating water deficit in other plant species. Nevertheless, fructans, which are prebiotic compounds, have not been described nor studied in Aloe vera, whose leaf gel is known to possess beneficial pharmaceutical, nutritional and cosmetic properties. As Aloe vera is frequently cultivated in semi-arid conditions, like those found in northern Chile, we investigated the effect of water deficit on fructan composition and structure...
2016: PloS One
YoonJung Lee, Daniel H Atchley, Celia A Proctor, Forrest L Smith, SunYoung Yi, Chris M Loftis, Kenneth M Yates
UNLABELLED: New treatments are needed as infection risk associated with diabetic, venous, and pressure ulcers are becoming more prevalent as comorbidities of obesity, aging, and major disease. Postsurgical, burn, and immunocompromised patients are also at an increased risk of wounds and infection. Silver has been utilized in treating various wounds associated with infections and, although highly effective, caution is required for use beyond 2 weeks due to potential silver cytotoxicity...
December 2015: Wounds: a Compendium of Clinical Research and Practice
Angela M Quain, Nancy M Khardori
Wound care is a multidisciplinary specialty requiring many physiologic and immunologic processes as well as physical, social, and societal factors to achieve successful wound closure. Most wounds are treated with combinations of antimicrobials, protective barriers, and topical growth agents, including skin and biologic grafts.The role of nutrition in wound healing may be overlooked in the wound care patient. Like the specialty, it is often multifaceted, with many nutritional components playing a variety of roles in the wound healing process...
December 2015: Wounds: a Compendium of Clinical Research and Practice
Fatemeh Sholehvar, Davood Mehrabani, Parichehr Yaghmaei, Akbar Vahdati
BACKGROUND: Dental pulp stem cells (DPSCs) can play a prominent role in tissue regeneration. Aloe vera L. (Liliaceae) contains the polysaccharide of acemannan that was shown to be a trigger factor for cell proliferation, differentiation, mineralization, and dentin formation. AIM: This study sought to determine the viability of DPSCs in Aloe vera in comparison with Hank's balanced salt solution (HBSS). MATERIALS AND METHOD: Twelve rabbits underwent anesthesia, and their incisor teeth were extracted; the pulp tissue was removed, chopped, treated with collagenase and plated in culture flasks...
October 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Cláudio Rodrigues Rezende Costa, Bruna Rabelo Amorim, Pérola de Magalhães, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra
This systematic review aimed to evaluate the effects of plants on osteogenic differentiation and mineralization of human periodontal ligament cells. The included studies were selected using five different electronic databases. The reference list of the included studies was crosschecked, and a partial gray literature search was undertaken using Google Scholar and ProQuest. The methodology of the selected studies was evaluated using GRADE. After a two-step selection process, eight studies were identified. Six different types of plants were reported in the selected studies, which were Morinda citrifolia, Aloe vera, Fructus cnidii, Zanthoxylum schinifolium, Centella asiatica, and Epimedium species...
April 2016: Phytotherapy Research: PTR
Jaroenporn Chokboribal, Wanpen Tachaboonyakiat, Polkit Sangvanich, Vithaya Ruangpornvisuti, Suwimon Jettanacheawchankit, Pasutha Thunyakitpisal
Acemannan, an acetylated polymannose from Aloe vera, induces tissue repair. We investigated the role of acemannan's acetyl-groups on its physical and biological properties. Deacetylated acemannan (DeAcAM) was prepared and characterized. The physical properties and microscopic structure of DeAcAM were evaluated using water solubility, contact angle, X-ray diffraction, and scanning-electron microscopy. The activity of DeAcAM on cell proliferation and gene expression were assessed. Acemannan and DeAcAM structures were simulated and the acemannan tetramer diad and its completely deacetylated structure were also determined...
November 20, 2015: Carbohydrate Polymers
Siriporn Songsiripradubboon, Wijit Banlunara, Polkit Sangvanich, Chutima Trairatvorakul, Pasutha Thunyakitpisal
Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7-11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide...
September 2016: Odontology
Wei Xing, Wei Guo, Cun-Hua Zou, Ting-Ting Fu, Xiang-Yun Li, Ming Zhu, Jun-Hua Qi, Jiao Song, Chen-Hui Dong, Zhuang Li, Yong Xiao, Pei-Song Yuan, Hong Huang, Xiang Xu
BACKGROUND: Acemannan is a bioactive polysaccharides promoting tissue repair. However, the roles of acemannan in skin wound healing and the underlying molecular mechanisms are largely unclear. OBJECTIVE: The goal of this study is to investigate the positive role of acemannan in cutaneous wound healing and its mechanism. METHODS: Mouse skin wound model and skin primary fibroblasts were used to demonstrate the positive effect of acemannan on cutaneous wound healing...
August 2015: Journal of Dermatological Science
Beatriz Gullón, Patricia Gullón, Freni Tavaria, José Luis Alonso, Manuela Pintado
Aloe vera mucilage is reported to be rich in acemannan that is a polysaccharide with a backbone of β-(1→4)-D-mannose residues acetylated at the C-2 and C-3 positions and contains some side chains of galactose and arabinose attached to the C-6 carbon. The evaluation of the prebiotic potential of Aloe vera mucilage was carried out by in vitro fermentation using intestinal microbiota from six healthy donors as the inoculum. The prebiotic activity was assessed through the quantification of short chain fatty acids (SCFA) and the evaluation of dynamic bacterial population in mixed faecal cultures by fluorescence in situ hybridization (FISH)...
February 2015: Food & Function
Amada Yerén Escobedo-Lozano, Alain Domard, Carlos A Velázquez, Francisco M Goycoolea, Waldo M Argüelles-Monal
The aim of the present study was to investigate the mechanical and thermal properties of mixed chitosan-acemannan (CS-AC) mixed gels and the antibacterial activity of dilute mixed solutions of both polysaccharides. Physical hydrogels of chitosan comprising varying amounts of non-gelling acemannan were prepared by controlled neutralization of chitosan using ammonia. As the overall acemannan concentration in the mixed hydrogel increased while fixing that of CS, the mechanical strength decreased. These results indicate that AC perturbs the formation of elastic junctions and overall connectivity as it occurs in the isolated CS network...
January 22, 2015: Carbohydrate Polymers
Gerardo Daniel Sierra-García, Rocío Castro-Ríos, Azucena González-Horta, Jorge Lara-Arias, Abelardo Chávez-Montes
In this review, the composition, actions, and clinical applications of acemannan in medicine and its effectiveness as an adjunct in the treatment of diseases are presented. An electronic literature search was performed up to January 2014 for studies and research presenting data to validate the efficacy of acemannan. A total of 50 titles, abstracts and full-text studies were selected and reviewed. Acemannan has various medicinal properties like osteogenic, anti-inflammatory, and antibacterial, which accelerate healing of lesions...
August 2014: Natural Product Communications
Joana Simões, Fernando M Nunes, Pedro Domingues, Manuel A Coimbra, M Rosário Domingues
Aloe vera acemannan is a polysaccharide composed by a backbone of β-(1→4)-linked D-mannose residues interspersed by few glucose residues, acetylated in O-2, O-3, and O-6 containing side chains constituted by O-6-linked single α-D-galactose and α-L-arabinose residues. This structural features are rather similar to mannans from other sources, namely coffee and locust bean gum. However, Aloe vera acemannan and coffee mannans present immunostimulatory activity but locust bean gum does not. In order to know more about the structural features of a commercial preparation of Aloe vera presenting comparable immunostimulatory activity to that observed for coffee mannans, this preparation was submitted to sugar and methylation analysis...
September 1, 2012: Carbohydrate Polymers
P Chantarawaratit, P Sangvanich, W Banlunara, K Soontornvipart, P Thunyakitpisal
BACKGROUND AND OBJECTIVE: Periodontal disease is a common infectious disease, found worldwide, causing the destruction of the periodontium. The periodontium is a complex structure composed of both soft and hard tissues, thus an agent applied to regenerate the periodontium must be able to stimulate periodontal ligament, cementum and alveolar bone regeneration. Recent studies demonstrated that acemannan, a polysaccharide extracted from Aloe vera gel, stimulated both soft and hard tissue healing...
April 2014: Journal of Periodontal Research
Sani Boonyagul, Wijit Banlunara, Polkit Sangvanich, Pasutha Thunyakitpisal
Aloe vera is a traditional wound healing medicine. We hypothesized acemannan, a polysaccharide extracted from Aloe vera gel, could affect bone formation. Primary rat bone marrow stromal cells (BMSCs) were treated with various concentrations of acemannan. New DNA synthesis, VEGF, BMP-2, alkaline phosphatase activity, bone sialoprotein, osteopontin expression, and mineralization were determined by [(3)H] thymidine incorporation assay, ELISA, biochemical assay, western blotting, and Alizarin Red staining, respectively...
July 2014: Odontology
Kanokporn Bhalang, Pasutha Thunyakitpisal, Nuttanit Rungsirisatean
OBJECTIVES: The objective of this study was to elucidate the safety and effectiveness of acemannan, a polysaccharide extracted from Aloe vera, in the treatment of oral aphthous ulceration. DESIGN: A skin patch test was performed on 100 healthy subjects, and 0.5% acemannan in Carbopol® 934P NF (Lubrizol Corporation, USA) was applied to the oral mucosa of the lower lip of 50 healthy participants 3 times/day for 7 days. Oral examinations and blood tests measuring liver and kidney function were performed prior to, and following, 7 days of application to assess the side-effects of acemannan when used on oral mucosa...
May 2013: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Avinash S Bidra, Jeffery J Tarrand, Dianna B Roberts, Kenneth V Rolston, Mark S Chambers
OBJECTIVE: A variety of oral topical agents have been used for prevention and management of radiotherapy-induced adverse effects. The antimicrobial nature of some of the commonly used agents is unknown. The purpose of this study was to evaluate antimicrobial efficacies of various oral topical agents on common microorganisms associated with radiated head and neck cancer patients. METHOD AND MATERIALS: Seven commonly used topical oral agents-0.12% chlorhexidine with alcohol, 0...
April 2011: Quintessence International
Göksel Şimşek Kaya, Günay Yapici, Zeynep Savaş, Metin Güngörmüş
PURPOSE: The aim of the present randomized prospective clinical trial was to compare the effects of alvogyl, the SaliCept patch, and low-level laser therapy in the management of alveolar osteitis. PATIENTS AND METHODS: The study population included 104 patients who had been referred to our clinic with a complaint of alveolar osteitis. The patients were randomly assigned to 1 of 4 groups: group 1, curettage and irrigation alone; group 2, curettage and irrigation followed by alvogyl applied directly to the socket; group 3, curettage and irrigation followed by a SaliCept patch applied directly to the socket; and group 4, curettage and irrigation followed by continuous-mode diode laser irradiation (808 nm, 100 mW, 60 seconds, 7...
June 2011: Journal of Oral and Maxillofacial Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"