Caroline Andrique, Anne Laure Bonnet, Julien Dang, Julie Lesieur, A Michaela Krautzberger, Brigitte Baroukh, Coralie Torrens, Jeremy Sadoine, Alain Schmitt, Gael Y Rochefort, Claire Bardet, Isabelle Six, Pascal Houillier, Pierre Louis Tharaux, Heinrich Schrewe, Celine Gaucher, Catherine Chaussain
Bone diseases are increasing with aging populations and it is important to identify clues to develop innovative treatments. Vasn, which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, is expressed during the development in intramembranous and endochondral ossification zones. Here, we studied the impact of Vasn deletion on the osteoblast and osteoclast dialog through a cell Coculture model. In addition, we explored the bone phenotype of Vasn KO mice, either constitutive or tamoxifen-inducible, or with an osteoclast-specific deletion...
March 19, 2024: Journal of Cellular Physiology