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https://www.readbyqxmd.com/read/28550684/long-noncoding-rna-ccat2-knockdown-suppresses-tumorous-progression-by-sponging-mir-424-in-epithelial-ovarian-vancer
#1
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Epithelial ovarian cancer (EOC) is the one of most common gynecological malignant tumor with highest mortality, meanwhile, series of lncRNAs have been validated to play vital role in EOC tumorigenesis. Colon cancer-associated transcript 2 (CCAT2) has been verified as oncogenic lncRNA in multiple tumors, however, the role of CCAT2 in EOC genesis is still unclear. The purpose of present study is to probe the function of CCAT2 on EOC. Preliminary experiments found that CCAT2 expression was significantly up-regulated in EOC tissue and cell lines compared to noncancerous tissue and cells...
May 21, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550487/model-to-predict-cause-specific-mortality-in-patients-with-head-and-neck-adenoid-cystic-carcinoma-a-competing-risk-analysis
#2
EDITORIAL
Matin Imanguli, Baran D Sumer
No abstract text is available yet for this article.
May 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28550380/barriers-motivators-and-facilitators-to-engagement-in-hiv-care-among-hiv-infected-ghanaian-men-who-have-sex-with-men-msm
#3
Adedotun Ogunbajo, Trace Kershaw, Sameer Kushwaha, Francis Boakye, Nii-Dromo Wallace-Atiapah, LaRon E Nelson
In Ghana, men who have sex with men (MSM) bear a high burden of HIV. Identifying factors that influence engagement in HIV care among HIV-infected Ghanaian MSM is critical to devising novel interventions and strengthening existing programs aimed at improving outcomes across the HIV care continuum. Consequently, we conducted an exploratory qualitative research study with 30 HIV-infected Ghanaian MSM between May 2015 and July 2015. Common barriers were fear of being seen in HIV-related health facility, financial difficulties, and health system challenges...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550379/a-mixed-methods-exploration-of-the-needs-of-people-living-with-hiv-plwh-enrolled-in-access-to-care-a-national-hiv-linkage-retention-and-re-engagement-in-medical-care-program
#4
C Maulsby, B Enobun, D S Batey, K M Jain, M Riordan, M Werner, D R Holtgrave
Competing needs pose barriers to engagement in HIV medical care. Mixed methods were used to explore and describe the needs of participants enrolled in Access to Care, a national HIV linkage, retention and re-engagement in care (LRC) program that served people living with HIV who knew their status but were not engaged in care. When asked to prioritize their most urgent needs, participants reported housing or shelter (31%), HIV medical services (24%), and employment (8%). When we assessed the HIV continuum of care by needs status, we found no significant differences in linkage, retention, or viral suppression between participants with and without basic needs...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550157/competence-consent-and-complexity
#5
EDITORIAL
Ken Boyd
No abstract text is available yet for this article.
June 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28549819/rivaroxaban-for-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-and-active-cancer
#6
Eva S Laube, Anthony Yu, Dipti Gupta, Yimei Miao, Patrick Samedy, Jonathan Wills, Stephen Harnicar, Gerald A Soff, Simon Mantha
Rivaroxaban is broadly used for the primary prevention of stroke and systemic embolism in the general population with nonvalvular atrial fibrillation (AF). However, there is little published evidence on the safety and efficacy of rivaroxaban for AF in patients with active cancer. The aim of this study was to assess the safety and efficacy of rivaroxaban in patients with active cancer and AF. The use of rivaroxaban in patients with cancer at the Memorial Sloan Kettering Cancer Center is monitored in the setting of a Quality Assessment Initiative...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28549712/assessment-of-competence-in-evar-procedures-a-novel-rating-scale-developed-by-the-delphi-technique
#7
M Strøm, L Lönn, B Bech, T V Schroeder, L Konge
OBJECTIVE/BACKGROUND: To develop a procedure specific global rating scale for assessment of operator competence in endovascular aortic repair (EVAR). METHODS: A Delphi approach was used to achieve expert consensus. A panel of 32 international experts (median 300 EVAR procedures, range 200-3000) from vascular surgery (n = 21) and radiology (n = 11) was established. The first Delphi round was based on a review of endovascular skills assessment papers, stent graft instructions for use, and structured interviews...
May 23, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28549625/a-matter-of-maturity-the-impact-of-pre-mrna-processing-in-gene-expression-and-antigen-presentation
#8
Rodrigo Prado Martins, Robin Fåhraeus
RNA processing plays a pivotal role in the diversification of high eukaryotes transcriptome and proteome. The expression of gene products controlling a variety of cellular and physiological processes depends largely on a complex maturation process undergone by pre-mRNAs to become translation-competent mRNAs. Here we review the different mechanisms involved in the pre-mRNA processing and disclose their impact in the gene regulation process in eukaryotic cells. We describe some viral strategies targeting pre-mRNA processing to control gene expression and host immune response and discuss their relevance as tools for a better understanding of cell biology...
May 23, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28549577/-child-behaviour-problems-and-parenting-skills-of-mothers-in-environments-of-intimate-partner-violence
#9
Ana Rosser Limiñana, Raquel Suriá Martínez, Miguel Ángel Mateo Pérez
OBJECTIVE: To assess the behavioural problems of children who have been exposed to intimate partner violence situations, and the moderating effect of mother parenting. METHOD: We analysed, using the Child Behavior CheckList, behavioural problems of 46 children between 6 and 16 years, and the relationship between the detected problems and parenting skills shown in the mother-child interaction in shelters. RESULTS: Increased behavioural problems were detected in children, compared with normative population...
May 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28549513/assessment-of-the-accuracy-and-consistency-in-the-application-of-standardized-surveillance-definitions-a-summary-of-the-american-journal-of-infection-control-and-national-healthcare-safety-network-case-studies-2010-2016
#10
Marc-Oliver Wright, Katherine Allen-Bridson, Joan N Hebden
BACKGROUND: The Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) surveillance definitions are the most widely used criteria for health care-associated infection (HAI) surveillance. NHSN participants agree to conduct surveillance in accordance with the NHSN protocol and criteria. To assess the application of these standardized surveillance specifications and offer infection preventionists (IPs) opportunities for ongoing education, a series of case studies, with questions related to NHSN definitions and criteria were published...
June 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549510/understanding-the-current-state-of-infection-preventionists-through-competency-role-and-activity-self-assessment
#11
Ericka L Kalp, James F Marx, James Davis
BACKGROUND: The Association for Professionals in Infection Control and Epidemiology (APIC) MegaSurvey, administered in 2015, was completed by approximately 4,079 APIC members. The survey sought to gain a better understanding the current state of 4 components of infection prevention practice: demographic characteristics, compensation, organizational structure, and practice and competency. METHODS: The data for this analysis come from the APIC MegaSurvey Practice and Competency domain...
June 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549463/factors-associated-with-length-of-stay-following-trans-catheter-aortic-valve-replacement-a-multicenter-study
#12
Yaron Arbel, Nevena Zivkovic, Dhruven Mehta, Sam Radhakrishnan, Stephen E Fremes, Effat Rezaei, Asim N Cheema, Sami Al-Nasser, Ariel Finkelstein, Harindra C Wijeysundera
BACKGROUND: Most patients undergoing Transcatheter aortic valve implantation (TAVR) are elderly with significant co-morbidities and there is limited information available regarding factors that influence length of stay (LOS) post-procedure. The aim of this study was to identify the patient, and procedural factors that affect post-TAVR LOS using a contemporary multinational registry. METHODS: We conducted a retrospective cohort study, with patients recruited from three high volume tertiary institutions...
May 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28549461/the-effect-of-white-coats-and-gender-on-medical-students-perceptions-of-physicians
#13
Malika Ladha, Aleem Bharwani, Kevin McLaughlin, Henry T Stelfox, Adam Bass
BACKGROUND: Despite the fact that medical schools spend a considerable effort to rate clinical instructors, there is limited evidence regarding the effect of physical characteristics on instructor ratings. White coats have been shown to alter patients' perceptions of physicians although it has not been determined if preceptors who wear white coats are rated differently than their colleagues. METHODS: Second year medical students were administered a questionnaire with four clinical scenarios depicting medical errors accompanied by a picture of a physician of different sexes and ethnicities...
May 26, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28549459/-a-steep-learning-curve-junior-doctor-perspectives-on-the-transition-from-medical-student-to-the-health-care-workplace
#14
Nancy Sturman, Zachary Tan, Jane Turner
BACKGROUND: The transition from medical student to hospital-based first year junior doctor (termed "intern" in Australia) is known to be challenging, and recent changes in clinical learning environments may reduce graduate preparedness for the intern workplace. Although manageable challenges and transitions are a stimulus to learning, levels of burnout in junior medical colleagues are concerning. In order to prepare and support medical graduates, educators need to understand contemporary junior doctor perspectives on this transition...
May 26, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28549443/quantitative-analysis-of-cryptic-splicing-associated-with-tdp-43-depletion
#15
Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian M Isaacs, Vincent Plagnol
BACKGROUND: Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the aberrant inclusion of cryptic exons into a range of transcripts, but their extent, relevance to disease pathogenesis and whether they are caused by other RNA-binding proteins implicated in ALS/FTD are unknown...
May 26, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28549427/developing-an-australian-first-recovery-model-for-parents-in-victorian-mental-health-and-family-services-a-study-protocol-for-a-randomised-controlled-trial
#16
Darryl Maybery, Melinda Goodyear, Andrea Reupert, Jade Sheen, Warren Cann, Kim Dalziel, Phillip Tchernagovski, Brendan O'Hanlon, Henry von Doussa
BACKGROUND: A considerable number of people with a mental illness are parents caring for dependent children. For those with a mental illness, parenting can provide a sense of competence, belonging, identity and hope and hence is well aligned to the concept of personal recovery. However, little research has focused on the recovery journey of those who are parents and have a mental illness. This randomised controlled trial aims to (i) evaluate the effectiveness of an intervention model of recovery for parents (Let's Talk about Children) in three different mental health service sectors and (ii) examine the economic value of a larger roll out (longer term) of the parent recovery model...
May 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28549409/a-qualitative-study-of-immigrant-women-on-long-term-sick-leave-and-their-experience-of-dignity
#17
Line Nortvedt, Bernadette Nirmal Kumar, Vibeke Lohne
PURPOSE: The purpose of this study was to explore if and how immigrant women suffering from chronic pain experience and maintain their dignity, during rehabilitation. METHODS: The study was designed as a field study, with participant observation and in-depth interviews. Participant observations were carried out during a rehabilitation course for 14 immigrant women on an outpatient clinic at a rehabilitation hospital in southern Norway. In-depth interviews were performed after the rehabilitation period...
May 26, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28549405/twelve-tips-for-the-implementation-of-epas-for-assessment-and-entrustment-decisions
#18
Harm Peters, Ylva Holzhausen, Christy Boscardin, Olle Ten Cate, H Carrie Chen
The concept of entrustable professional activities (EPAs) reframes the approach to assessment in competency-based medical education. Key to this concept is the linking of assessment to decision making about entrusting learners with clinical responsibilities. Based on recent literature and the authors' experiences with implementing EPAs, this article provides practical recommendations for how to implement EPAs for assessment and entrustment decisions in the workplace. Tips for supervising clinicians include talking to learners about trust, using EPA descriptions to guide learning and teaching, providing learners with greater ad hoc responsibilities, using EPAs to identify/create opportunities for assessment and feedback, including case-based discussions and acknowledging gut feelings about learner readiness for more autonomy...
May 26, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28549120/dementia-capable-care-coordination-in-duals-demonstration-programs-workforce-needs-promising-practices-and-policy
#19
Brooke Hollister, Jason D Flatt, Susan A Chapman
Background and Objectives: This study describes the program requirements, workforce competencies, and barriers for dementia capable care coordination within health plans from seven states participating in the Center for Medicare and Medicaid Services demonstration programs for dually-eligible Medicare and Medicaid beneficiaries. Research Design and Methods: Data came from contracts, policy documents, and 24 semistructured key informant interviews with national experts and leaders from community-based organizations, advocacy organizations, researchers, federal and state government, and health plans in the seven states...
May 25, 2017: Gerontologist
https://www.readbyqxmd.com/read/28549113/restrictive-enlargement-of-the-pulmonary-annulus-at-repair-of-tetralogy-of-fallot-a-comparative-10-year-follow-up-study%C3%A2
#20
Jana Logoteta, Lars Dullin, Jan Hinnerk Hansen, Carsten Rickers, Mona Salehi Ravesh, Abdullah Al Bulushi, Ines Kristo, Philip Wegner, Michael Schumacher, Tim Attmann, Jens Scheewe, Hans-Heiner Kramer
OBJECTIVES: Since 1996, our centre performs restrictive enlargement of the pulmonary annulus at surgical repair of tetralogy of Fallot. A transannular patch is only used if the z-score of the pulmonary annulus is smaller than -2. We sought to determine whether this strategy reduces pulmonary insufficiency (PI) and reoperation rate compared to a nationwide contemporary cohort that has not been operated using a uniform strategy. METHODS: Eighty-seven tetralogy of Fallot patients were included in the study (Group 1)...
May 26, 2017: European Journal of Cardio-thoracic Surgery
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