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https://www.readbyqxmd.com/read/28743020/animal-communication-when-i-m-calling-you-will-you-answer-too
#1
Neil J Vickers
Male moths compete to arrive first at a female releasing pheromone. A new study reveals that additional pheromone cues released only by younger females may prompt males to avoid them in favor of older but more fecund females.
July 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28743005/xenopus-laevis-m18bp1-directly-binds-existing-cenp-a-nucleosomes-to-promote-centromeric-chromatin-assembly
#2
Bradley T French, Frederick G Westhorpe, Charles Limouse, Aaron F Straight
Vertebrate centromeres are epigenetically defined by nucleosomes containing the histone H3 variant, CENP-A. CENP-A nucleosome assembly requires the three-protein Mis18 complex (Mis18α, Mis18β, and M18BP1) that recruits the CENP-A chaperone HJURP to centromeres, but how the Mis18 complex recognizes centromeric chromatin is unknown. Using Xenopus egg extract, we show that direct, cell-cycle-regulated binding of M18BP1 to CENP-A nucleosomes recruits the Mis18 complex to interphase centromeres to promote new CENP-A nucleosome assembly...
July 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28742830/regulatory-effects-of-zinc-on-cadmium-induced-cytotoxicity-in-chronic-inflammation
#3
Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre Miossec
OBJECTIVES: Zinc (Zn) has major effects on immune system activation while Cadmium (Cd) has anti-inflammatory and anti-proliferative effects in several chronic inflammatory contexts. The aim of this work was to investigate by which mechanisms Zn could compete with Cd and eventually counteract its deleterious effects. Rheumatoid arthritis (RA) synoviocytes exposed to cytokines were used as a model of chronic inflammation; osteoarthritis (OA) synoviocytes were used as control. METHODS: Cell/medium fractionation constants were analyzed for different metals by inductively-coupled-plasma mass-spectrometry by comparison to the 70Zn spike...
2017: PloS One
https://www.readbyqxmd.com/read/28742763/implementation-of-a-national-workplace-wellness-program-for-health-workers-in-botswana
#4
Jenny H Ledikwe, Bazghina-Werq Semo, Miram Sebego, Maureen Mpho, Heather Mothibedi, Shreshth Mawandia, Gabrielle O'Malley
: The Botswana workplace wellness program (WWP) for health care workers (HCWs) was initiated in 2007. WWP implementation was assessed using a sequential, explanatory, mixed methods design including a national implementation assessment (27 health districts) and in-depth interviews (n = 38). Level of implementation varied across districts with health screening, therapeutic recreation, and health promotion implemented more frequently than occupational health activities and psychosocial services. Facilitators to WWP implementation included establishment of a dedicated, diverse WWP committee; provision of administrative support, and integration of activities into organizational culture...
July 24, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28742717/integrating-an-interprofessional-education-experience-into-a-human-physiology-course
#5
Scott Edwards, Patricia E Molina, Kathleen H McDonough, Donald E Mercante, Tina P Gunaldo
PURPOSE: To obtain physician assistant (PA) student perceptions about an interprofessional education (IPE) training experience embedded in a multidisciplinary science course. METHODS: An IPE training experience was integrated into a graduate human physiology course offered to PA, physical therapy, and graduate studies students. The focus of the activity related to the Interprofessional Education Collaborative (IPEC) competency domains of (1) roles and responsibilities and (2) teams and teamwork...
July 20, 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28742711/readiness-of-us-general-surgery-residents-for-independent-practice
#6
Brian C George, Jordan D Bohnen, Reed G Williams, Shari L Meyerson, Mary C Schuller, Michael J Clark, Andreas H Meier, Laura Torbeck, Samuel P Mandell, John T Mullen, Douglas S Smink, Rebecca E Scully, Jeffrey G Chipman, Edward D Auyang, Kyla P Terhune, Paul E Wise, Jennifer N Choi, Eugene F Foley, Justin B Dimick, Michael A Choti, Nathaniel J Soper, Keith D Lillemoe, Joseph B Zwischenberger, Gary L Dunnington, Debra A DaRosa, Jonathan P Fryer
OBJECTIVE: This study evaluates the current state of the General Surgery (GS) residency training model by investigating resident operative performance and autonomy. BACKGROUND: The American Board of Surgery has designated 132 procedures as being "Core" to the practice of GS. GS residents are expected to be able to safely and independently perform those procedures by the time they graduate. There is growing concern that not all residents achieve that standard. Lack of operative autonomy may play a role...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742408/risk-competence-in-dealing-with-alcohol-and-other-drugs-in-adolescence
#7
Ede Nagy, Rolf Verres, Dennis Grevenstein
BACKGROUND: Adolescence is a critical phase for the development substance use patterns. We propose that individual competence in dealing with psychoactive substances is crucial for the development of healthy substance use behavior and prevention of substance misuse or addiction. OBJECTIVES: We present a new concept of health related skills in dealing with alcohol and other drugs in adolescence, its operationalization and validation. Our conception of risk competence (RICO) consists of the four major factors being Reflective, Informed, Self-Controlled and Life-Oriented, and their sub-facets...
July 25, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28742130/association-between-complicated-liver-cirrhosis-and-the-risk-of-hepatocellular-carcinoma-in-taiwan
#8
Tsung-Hsing Hung, Chih-Ming Liang, Chien-Ning Hsu, Wei-Chen Tai, Kai-Lung Tsai, Ming-Kun Ku, Jiunn-Wei Wang, Kuo-Lun Tseng, Lan-Ting Yuan, Seng-Howe Nguang, Shih-Cheng Yang, Cheng-Kun Wu, Pin-I Hsu, Deng-Chyang Wu, Seng-Kee Chuah
Hepatic encephalopathy, ascites, and variceal bleeding are the three major complications of cirrhosis. It is well known that cirrhosis is the most important risk factor of hepatocellular carcinoma (HCC). However, little is known about whether the severity of liver cirrhosis has an effect on the incidence of HCC. This population-based cohort study aimed to explore the association between complicated cirrhosis and HCC, and identify the risk factors of HCC in patients with complicated cirrhosis. Data of the years 1997-2011 were extracted from the National Health Insurance Research Database of Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28742100/a-multifactor-approach-to-forecasting-romanian-gross-domestic-product-gdp-in-the-short-run
#9
Daniel Armeanu, Jean Vasile Andrei, Leonard Lache, Mirela Panait
The purpose of this paper is to investigate the application of a generalized dynamic factor model (GDFM) based on dynamic principal components analysis to forecasting short-term economic growth in Romania. We have used a generalized principal components approach to estimate a dynamic model based on a dataset comprising 86 economic and non-economic variables that are linked to economic output. The model exploits the dynamic correlations between these variables and uses three common components that account for roughly 72% of the information contained in the original space...
2017: PloS One
https://www.readbyqxmd.com/read/28742023/genome-wide-identification-of-lineage-and-locus-specific-variation-associated-with-pneumococcal-carriage-duration
#10
John A Lees, Nicholas J Croucher, David Goldblatt, François Nosten, Julian Parkhill, Claudia Turner, Paul Turner, Stephen D Bentley
Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for disease, but variability in its duration is currently only understood at the serotype level. Here we developed a model to calculate the duration of carriage episodes from longitudinal swab data, and combined these results with whole genome sequence data. We estimated that pneumococcal genomic variation accounted for 63% of the phenotype variation, whereas the host traits considered here (age and previous carriage) accounted for less than 5%...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28741969/the-importance-of-research-literacy-for-yoga-therapists
#11
Steffany Moonaz, Pamela Jeter, Laura Schmalzl
Evidence-Informed Practice (EIP) utilizes the three components of expert opinion, research evidence, and client values. It is a recommended training competency for integrative health practitioners in diverse fields, such as acupuncture and massage therapy. Research Literacy (RL) is a necessary pre-requisite to EIP. Many yoga therapists have limited training in these skills, which negatively impacts inter-professional communication and collaboration, as well as further advancement of yoga therapy research and practice...
July 25, 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/28741943/reductive-etherification-via-anion-binding-catalysis
#12
Chenfei Zhao, Christopher A Sojdak, Wazo Myint, Daniel Seidel
Reductive condensations of alcohols with aldehydes/ketones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates in combination with HCl. 1,1,3,3-tetramethyldisiloxane serves as a convenient reducing reagent. This strategy is applicable to challenging substrate combinations and exhibits functional group tolerance. Competing reductive homocoupling of the carbonyl component is suppressed.
July 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28741934/mixed-spin-diamond-chain-cu2fepo4f4-h2o-4-with-a-noncollinear-spin-order-and-possible-successive-phase-transitions
#13
Hongcheng Lu, Naoaki Hayashi, Yuki Matsumoto, Hiroshi Takatsu, Hiroshi Kageyama
A diamond spin chain system, one of the one-dimensional frustrated lattices, is known to exhibit novel properties, but experimental studies have been exclusively confined to materials with a single spin component. Here, we report on the synthesis, structure, and magnetic properties of a new diamond chain compound Cu2FePO4F4(H2O)4 1 composed of mixed-spins of Cu(2+) (S = 1/2 × 2) and Fe(3+) (S = 5/2). Compound 1 crystallizes in the space group C2/c of the monoclinic crystal system with a = 7.7546(4) Å, b = 12...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28741875/depression-and-anxiety-among-emergency-department-patients-utilization-and-barriers-to-care
#14
Beau Abar, Ashley Holub, Joseph Lee, Vincent DeRienzo, Flavia Nobay
BACKGROUND: Anxiety and depression rates among ED patients are substantially higher than in the general population. Additionally, those with mental health issues often have difficulty accessing care. Unfortunately, issues of anxiety and depression are frequently not addressed in the ED due to competing care priorities. This may lead to increased burden and overcrowding in EDs. OBJECTIVE: This study related anxiety and depression with ED utilization and perceived barriers to care...
July 25, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28741801/attitudes-toward-suicidal-behavior-and-associated-factors-among-nursing-professionals-a-quantitative-study
#15
Kelly Graziani Giacchero Vedana, Daniel Fernando Magrini, Ana Carolina Guidorizzi Zanetti, Adriana Inocenti Miasso, Tatiana Longo Borges, Manoel Antônio Dos Santos
BACKGROUND: The attitudes toward suicide of emergency nurses may affect the care provided. However, the factors associated with these attitudes remain unclear. OBJECTIVE: To investigate attitudes toward suicidal behavior and associated factors among nursing professionals working in emergency settings. METHODS: A cross-sectional observational study including 28 nurses and 118 were nursing assistants employed at two emergency services in Brazil was conducted...
July 25, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28741649/the-effect-of-metrics-based-feedback-on-acquisition-of-sonographic-skills-relevant-to-performance-of-ultrasound-guided-axillary-brachial-plexus-block
#16
O M A Ahmed, T Niessen, B D O'Donnell, A G Gallagher, D S Breslin, A DunnGalvin, G D Shorten
The objective of this study was to examine the effect of metrics-based vs. non-metrics-based feedback on novices learning predefined competencies for acquisition and interpretation of sonographic images relevant to performance of ultrasound-guided axillary brachial plexus block. Twelve anaesthetic trainees were randomly assigned to either metrics-based-feedback or non-metrics-based feedback groups. After a common learning phase, all participants attempted to perform a predefined task that involved scanning the left axilla of a single volunteer...
July 25, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28741600/coverage-based-constraints-for-imrt-optimization
#17
Henning Mescher, Silke Ulrich, Mark Bangert
Radiation therapy treatment planning requires an incorporation of uncertainties in order to guarantee an adequate irradiation of the tumor volumes. In current clinical practice, uncertainties are accounted for implicitly with an expansion of the target volume according to generic margin recipes. Alternatively, it is possible to account for uncertainties by explicit minimization of objectives that describe worst case treatment scenarios, the expectation value of the treatment, or the coverage probability of the target volumes during treatment planning...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28741274/cyclin-dependent-kinase-4-6-inhibitors-in-breast-cancer-palbociclib-ribociclib-and-abemaciclib
#18
REVIEW
Dorota Kwapisz
PURPOSE: The cyclin D-cyclin dependent kinase (CDK) 4/6-inhibitor of CDK4 (INK4)-retinoblastoma (Rb) pathway plays a crucial role in cell cycle progression and its dysregulation is an important contributor to endocrine therapy resistance. CDK4/6 inhibitors trigger cell cycle arrest in Rb protein (pRb)-competent cells. Recent years have seen the development of selective CDK4/6 inhibitors, which have delivered promising results of efficacy and manageable safety profiles. The main objective of this review is to discuss preclinical and clinical data to date, and ongoing clinical trials with palbociclib, ribociclib, and abemaciclib in breast cancer...
July 24, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28741127/wing-morphology-winter-ecology-and-fecundity-selection-evidence-for-sex-dependence-in-barn-swallows-hirundo-rustica
#19
Nicola Saino, Roberto Ambrosini, Manuela Caprioli, Felix Liechti, Andrea Romano, Diego Rubolini, Chiara Scandolara
Variation in wing morphology results from the combination of diverse selection pressures. Wing feather morphology within species varies with sex and ontogenetic effects, and also with ecological factors. Yet, the direction of causation for the wing morphology-ecology association remains to be elucidated. Under the 'ecology-dependence' hypothesis, wing morphology covaries with ecological conditions, because the latter affect feather molt. Alternatively, the 'habitat choice' hypothesis posits that individuals with different wing morphology choose different habitats because of the habitat-dependent advantages of a specific wing morphology...
July 25, 2017: Oecologia
https://www.readbyqxmd.com/read/28740789/a-unique-lymphaticovenous-supermicrosurgery-training-curriculum-reflections-on-validation-and-competency-thresholds
#20
Georgios Pafitanis, Mitsunaga Narushima, Mitsunobu Harima, Ali Ghanem, Simon Myers, Isao Koshima
Supermicrosurgery is becoming a commonly used technique in various subspecialties of reconstructive surgery. However, there is a lack of standardization and validation in novel supermicrosurgical training. Current simulation training programs are not adequately focused on the challenges encountered during clinical supermicrosurgery practice. This article describes the authors' experience utilizing a supermicrosurgery competency-based training curriculum, in a simulation-based environment, toward safe clinical practice for lymphatic submillimeter supermicrovascular surgery...
June 2017: Plastic and Reconstructive Surgery. Global Open
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