keyword
MENU ▼
Read by QxMD icon Read
search

competency

keyword
https://www.readbyqxmd.com/read/28636205/progressive-scar14-with-unclear-speech-developmental-delay-tremor-and-behavioral-problems-caused-by-a-homozygous-deletion-of-the-sptbn2-pleckstrin-homology-domain
#1
Esra Yıldız Bölükbaşı, Muhammad Afzal, Sara Mumtaz, Nafees Ahmad, Sajid Malik, Aslıhan Tolun
We report on nine members of a consanguineous Pakistani family with primary presentation of intellectual disability, developmental delay, limb and gait ataxia, behavioral and speech problems, and tremor. By linkage mapping and exome sequencing we identified novel homozygous splicing variant c.6375-1G>C in SPTBN2. To date, only two other SPTBN2 mutations with recessive pattern of inheritance causing SCAR14 (spinocerebellar ataxia, autosomal recessive 14) that manifest with developmental ataxia and cognitive impairment, or cerebellar ataxia, mental retardation, and pyramidal signs have been reported...
June 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28636162/cobalt-catalyzed-ortho-c-h-functionalization-alkyne-annulation-of-benzylamine-derivatives-access-to-dihydroisoquinolines
#2
Angel Manu Martínez, Nuria Rodríguez, Ramon Gomez-Arrayas, Juan C Carretero
A practical picolinamide-directed C-H functionalization/alkyne annulation of benzylamine derivatives enabling the access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O2 as the sole oxidant and Co(OAc)2 as precatalyst. The method is compatible with both internal and terminal alkynes and shows high versatility and functional-group tolerance. Furthermore, full preservation of enantiopurity is observed when using non-racemic alpha-substituted benzylamine derivatives...
June 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28636081/cell-size-and-wall-dimensions-drive-distinct-variability-of-earlywood-and-latewood-density-in-northern-hemisphere-conifers
#3
Jesper Björklund, Kristina Seftigen, Fritz Schweingruber, Patrick Fonti, Georg von Arx, Marina V Bryukhanova, Henri E Cuny, Marco Carrer, Daniele Castagneri, David C Frank
Interannual variability of wood density - an important plant functional trait and environmental proxy - in conifers is poorly understood. We therefore explored the anatomical basis of density. We hypothesized that earlywood density is determined by tracheid size and latewood density by wall dimensions, reflecting their different functional tasks. To determine general patterns of variability, density parameters from 27 species and 349 sites across the Northern Hemisphere were correlated to tree-ring width parameters and local climate...
June 21, 2017: New Phytologist
https://www.readbyqxmd.com/read/28635315/age-stereotypes-flexible-goal-adjustment-and-well-being-among-chinese-older-adults
#4
Jinfeng Zhang, Yu Nancy Xiaonan, Jianxin Zhang, Mingjie Zhou
Previous studies have examined the independent roles of positive age stereotypes (PAS) and negative age stereotypes (NAS) in successful aging. This study aimed to examine the joint effect of PAS and NAS on the well-being of Chinese older adults, and to further examine whether this effect was moderated by flexible goal adjustment (FGA). Using a cross-sectional design, 279 Chinese older adults (age range 60‒97 years) completed measures related to age stereotypes, FGA, and well-being. The results showed that PAS interacted with NAS to predict well-being...
June 21, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28634765/a-450-year-old-turkish-poem-on-medical-ethics
#5
REVIEW
Halil Tekiner
The Ottoman physician-poet Nidai of Ankara (1509 to post-1567) studied medicine in Crimea and served as a court physician in Istanbul during the reign of Sultan Selim II. Nidai marked the classical period of Ottoman medicine particularly with his acclaimed works and translations in Turkish, among which Manafi al-Nas (Benefits of People, 1566) became widely known. The final chapter of Manafi al-Nas also is known independently under the name Vasiyyetname (Last Will), which is a remarkable guide on medical ethics...
June 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28634714/microbial-community-shift-in-a-suspended-stuffing-biological-reactor-with-pre-attached-aerobic-denitrifier
#6
Cong Du, Chongwei Cui, Shan Qiu, Shanwen Xu, Shengnan Shi, Thangavel Sangeetha, Fang Ma
Bioaugmentation is substantially determined by pre-attached communities in biological stuffing systems. However, the inevitable changes of microbial community shift occurred between pre-attached microorganisms on stuffing material and other existing communities in wastewater. Targeting at nitrogen removal in aerobic denitrification reactors, biological augmentation was built by polyurethane supporting material and aerobic denitrification bacteria of Pseudomonas stutzeri strains were primarily colonized. The total nitrogen removal reached a high efficiency of 77 ± 6%, resulting from a relative high nitrate removal (90%) and a low nitrite production of 24 mg l(-1)...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28634707/parent-support-of-preschool-peer-relationships-in-younger-siblings-of-children-with-autism-spectrum-disorder
#7
Annette Estes, Jeffrey Munson, Tanya St John, Stephen R Dager, Amy Rodda, Kelly Botteron, Heather Hazlett, Robert T Schultz, Lonnie Zwaigenbaum, Joseph Piven, Michael J Guralnick
Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal peer competence and friendships in children with ASD. We describe differences in peer relationships among three groups of preschool-aged children (15 HR-ASD, 53 HR-NonASD, 40 low-risk, LR), and examine parent support activities at home and arranging community-based peer activities...
June 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28634384/alternative-splicing-regulates-distinct-subcellular-localization-of-epithelial-splicing-regulatory-protein-1-esrp1-isoforms
#8
Yueqin Yang, Russ P Carstens
Epithelial-Splicing-Regulatory-Protein 1 (Esrp1) is a cell-type specific RNA-binding protein (RBP) that is essential for mammalian development through maintenance of epithelial cell properties including barrier function. Esrp1 also regulates splicing during the epithelial to mesenchymal transition (EMT). It contains three highly conserved RNA recognition motifs (RRMs) in the absence of other clearly defined protein domains. Esrp1 itself is also alternatively spliced to produce multiple protein isoforms. Here we determined that two competing alternative 5' splice sites in exon 12 yield Esrp1 isoforms with differential nucleocytoplasmic localization...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634231/hyperactivity-of-the-arabidopsis-cryptochrome-cry1-l407f-mutant-is-caused-by-a-structural-alteration-close-to-the-cry1-atp-binding-sit
#9
Christian Orth, Nils Niemann, Lars Hennig, Lars-Oliver Essen, Alfred Batschauer
Plant cryptochromes (cry) act as UV-A/blue light receptors. The prototype, Arabidopsis thaliana cry1, regulates several light responses during the life cycle, including de-etiolation, and is also involved in regulating flowering time. The cry1 photocycle is initiated by light absorption by its FAD chromophore, which is most likely fully oxidized (FADox) in the dark state and photoreduced to the neutral flavin semiquinone (FADH(o)) in its lit state. Cryptochromes lack the DNA-repair activity of the closely related DNA photolyases, but retain the ability to bind nucleotides such as ATP...
June 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28634129/state-of-the-art-review-of-biofuels-production-from-lignocellulose-by-thermophilic-bacteria
#10
REVIEW
Yujia Jiang, Fengxue Xin, Jiasheng Lu, Weiliang Dong, Wenming Zhang, Min Zhang, Hao Wu, Jiangfeng Ma, Min Jiang
Biofuels, including ethanol and butanol, are mainly produced by mesophilic solventogenic yeasts and Clostridium species. However, these microorganisms cannot directly utilize lignocellulosic materials, which are abundant, renewable and non-compete with human demand. More recently, thermophilic bacteria show great potential for biofuels production, which could efficiently degrade lignocellulose through the cost effective consolidated bioprocessing. Especially, it could avoid contamination in the whole process owing to its relatively high fermentation temperature...
June 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28633933/trajectories-of-self-evaluation-bias-in-primary-and-secondary-school-parental-antecedents-and-academic-consequences
#11
Arielle Bonneville-Roussy, Thérèse Bouffard, Carole Vezeau
Using a longitudinal approach spanning nine years of children's formal education, this study investigated the developmental trajectories of self-evaluation bias of academic competence. The study also examined how parenting styles were associated with the trajectories of bias in mid-primary school, and how those trajectories predicted academic outcomes at the end of secondary school and the beginning of college. A total of 711 children in 4th and 5th grades (mean age=10.71years old; 358 girls) participated in this study...
August 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28633750/evaluating-cultural-competency-and-patient-satisfaction-in-an-urban-dermatology-clinic
#12
Jordan V Wang, Nicholas Ross, Matthew Keller
Cultural competency continues to gain increased attention in medicine. Not only does it play a significant role in the delivery of health care and patient outcomes, but it also remains a major determinant of patient satisfaction. This study investigated how patients in an urban dermatology clinic rated their satisfaction with cultural competency. Compared to White patients, satisfaction scores were greater for Hispanic or Latino patients and less for Asian patients, while there was no significant difference for Black or African American patients...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633742/cutaneous-varicella-zoster-virus-infection-following-zoster-vaccination-report-of-post-vaccination-herpes-zoster-skin-infection-and-literature-review-of-zoster-vaccination-efficacy-and-guidelines
#13
Katherine M Stiff, Philip R Cohen
BackgroundHerpes zoster vaccine is currently recommended in the United States for immune competent individuals ≥60 years. The efficacy of the herpes zoster vaccine decreases with age and with time following vaccination.PurposeAn elderly man with herpes zoster following vaccination is described. The guidelines for vaccination and issues regarding re-vaccination are reviewed. METHODS: PubMed was used to search the following terms: efficacy, elderly, herpes zoster, herpes zoster incidence, herpes zoster recurrence, and vaccination...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633679/multistate-modeling-to-analyze-nosocomial-infection-data-an-introduction-and-demonstration
#14
Martin Wolkewitz, Maja von Cube, Martin Schumacher
OBJECTIVE Multistate and competing risks models have become an established and adequate tool with which to quantify determinants and consequences of nosocomial infections. In this tutorial article, we explain and demonstrate the basics of these models to a broader audience of professionals in health care, infection control, and hospital epidemiology. METHODS Using a publicly available data set from a cohort study of intensive care unit patients, we show how hospital infection data can be displayed and explored graphically and how simple formulas are derived under some simplified assumptions for illustrating the basic ideas behind multistate models...
June 21, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28633424/three-dimensional-3d-heparg-spheroid-model-with-physiologically-relevant-xenobiotic-metabolism-competence-and-hepatocyte-functionality-for-liver-toxicity-screening
#15
Sreenivasa C Ramaiahgari, Suramya Waidyanatha, Darlene Dixon, Michael J DeVito, Richard S Paules, Stephen S Ferguson
Effective prediction of human responses to chemical and drug exposure is of critical importance in environmental toxicology research and drug development. While significant progress has been made to address this challenge using in vitro liver models, these approaches often fail due to inadequate tissue model functionality. Herein, we describe the development, optimization, and characterization of a novel three-dimensional (3D) spheroid model using differentiated HepaRG cells that achieve and maintain physiologically-relevant levels of xenobiotic metabolism (CYP1A2, CYP2B6, and CYP3A4/5)...
June 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28633287/genetic-diseases-and-aneuploidies-can-be-detected-with-a-single-blastocyst-biopsy-a-successful-clinical-approach
#16
Maria Giulia Minasi, Francesco Fiorentino, Alessandra Ruberti, Anil Biricik, Elisabetta Cursio, Ettore Cotroneo, Maria Teresa Varricchio, Matteo Surdo, Francesca Spinella, Ermanno Greco
STUDY QUESTION: Can simultaneous detection of aneuploidies and genetic diseases or chromosomal aberrations in blastocysts reduce the chance of transferring embryos with low implantation potential, guaranteeing good clinical outcomes? SUMMARY ANSWER: The screening for chromosomal aneuploidies revealed that 50.6% of blastocysts diagnosed free of genetic disease or balanced, were aneuploid, therefore avoiding the transfer of blastocysts potentially resulting in implantation failures, miscarriages, or in some cases, in health affected live births...
June 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28633170/teaching-primary-care-genetics-a-randomized-controlled-trial-comparison
#17
Deanna Telner, June C Carroll, Glenn Regehr, Diana Tabak, Kara Semotiuk, Risa Freeman
BACKGROUND AND OBJECTIVE: Given the increasing discussions of the impact of genetic medicine within family medicine, it is important to determine the most effective way of teaching this material to family medicine residents (FMRs). The objective of this study was to evaluate and compare the impact of three methods of delivering primary care genetic content to FMRs. METHODS: Curriculum materials and assessment tools were created to teach and evaluate knowledge, skills, and attitudes around four core competencies in primary care genetics, with a focus on hereditary colorectal cancer (CRC)...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28632885/restoring-facial-symmetry-through-non-surgical-cosmetic-procedures-after-permanent-facial-paralxsis-a-case-report
#18
Ali Sahan, Funda Tamer
Facial nerve paralysis can occur due to infection, inflammation, trauma, surgery, and tumors. It leads to facial asymmetry, impaired oral competence, articulation deficits, and psychological problems. Treatment options include physical therapy, static slings, nerve and muscle transfers, blepharoplasty, brow lift, and chemodenervation with botulinum toxin. We report the case of a 66-year-old Caucasian female with permanent facial paralysis following middle ear surgery. The facial asymmetry was treated successfully with botulinum toxin A injection, hyaluronic acid dermal filler injection, and a thread-lift procedure...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28632670/competency-assessment-in-regional-anesthesia-quantity-today-quality-tomorrow
#19
Brian F S Allen, Matthew D McEvoy
No abstract text is available yet for this article.
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28632537/platelet-counts-and-postoperative-stroke-after-coronary-artery-bypass-grafting-surgery
#20
Jörn A Karhausen, Alan M Smeltz, Igor Akushevich, Mary Cooter, Mihai V Podgoreanu, Mark Stafford-Smith, Susan M Martinelli, Manuel L Fontes, Miklos D Kertai
BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated with stroke. METHODS: We evaluated 6 130 adult CABG surgery patients. Postoperative platelet counts were evaluated as continuous and categorical (mild versus moderate to severe) predictors of stroke. Extended Cox proportional hazard regression analysis with a time-varying covariate for daily minimum postoperative platelet count assessed the association of day-to-day variations in postoperative platelet count with time to stroke...
June 17, 2017: Anesthesia and Analgesia
keyword
keyword
372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"