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Dongqiang Hu, Yingying Fan, Yanglan Tan, Ye Tian, Na Liu, Lan Wang, Duoyong Zhao, Cheng Wang, Aibo Wu
Xinjiang jujubes (zizyphus rhamnaceae) are important agro-economically foods with the highest planting area and yields in China, however, black spot disease and contaminated Alternaria toxins have unfortunately caused decline or loss of jujubes nutritional quality in recent years. In this study, we used ultra-high performance liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-Orbitrap HRMS) to profile both Alternaria toxins and components in three representative Xinjiang jujubes, Hami Huang (HM), Hetian Jun (HT) and Ruoqiang Hui (RQ)...
September 7, 2017: Journal of Agricultural and Food Chemistry
Yohei Mitsuhashi, Yukihiro Furusawa, Tadashi Aradate, Qing-Li Zhao, Rohan Moniruzzaman, Masahiko Kanamori, Kyo Noguchi, Takashi Kondo
3-O-trans-p-coumaroyl-alphitolic acid (3OTPCA), a triterpenoid isolated from the plant Zizyphus jujuba (ZJ), is known to be cytotoxic to cancer cells; however, the molecular mechanism underlying 3OTPCA-induced cell death remains unknown. Here, we provide novel evidence that 3OTPCA induces apoptotic cell death in human leukemia cells. We found that 3OPTCA induces DNA fragmentation within 24 h after treatment in U937 cells, which was also observed in other leukemia cell lines, including Molt-4 and Jurkat cells...
2017: PloS One
Yuqing Cai, Xinping Zhou, Aizhi Han, Peng Chen, Hongjin Bai
Two homogenous biological macromolecules, designated as JJC1 and JJC2 were extracted from Zizyphus jujube cv. Jinchangzao. Their molecular weights were determined to be 56.03 and 112.11kDa by high performance gel permeation chromatography (HPGPC), respectively. Chemical and spectral analysis indicated that both JJC1 and JJC2 mainly consisted of lignin, along with carbohydrates (∼18%). Both JJC1 and JJC2 could stimulate the proliferation of spleen lymphocytes, and enhance phagocytosis and NO production of RAW264...
July 8, 2017: International Journal of Biological Macromolecules
Pu Yunfeng, Tian Ding, Wang Wenjun, Xiang Yanju, Xingqian Ye, Li Mei, Donghong Liu
BACKGROUND: The taste of dried jujube fruit when compared with fresh one is less palatable, as it developed bitterness during drying and storage. Therefore, the revelation of bitterness formation is essential for developing strategies for processing and storage. RESULTS: Bitterness in fresh jujube fruit was negligible, however, increased by 0.9, 1.5 and 1.8 folds during drying and storage over 6 and 12 months. The moisture significantly decreased during harvesting and drying...
June 30, 2017: Journal of the Science of Food and Agriculture
Fenjuan Shao, Qiang Lu, Iain W Wilson, Deyou Qiu
SQUAMOSA Promoter-Binding Protein-Likes (SPLs) are plant specific transcription factors playing important roles in plant growth and development. The SPL gene family has been studied in various plant species; however, there is no report about SPLs in Zizyphus jujuba. In this study, we identified 18 putative ZjSPL genes in Z. jujuba using a genome-wide analysis. Sequence features, gene structures, conserved domains and motifs were analyzed. The phylogenetic relationships of SPLs in Z. jujuba and A. thaliana were revealed...
June 23, 2017: Gene
Md Manowwar Alam, Abuzer Ali, Mohammad Ali, Showkat R Mir
BACKGROUND: The seeds of Zizyphus jujuba Mill. (Rhamnaceae) are astringent, aphrodisiac, tonic; used to cure cough, asthma, vomiting, burning sensation, biliousness, leucorrhoea, and eye infections in traditional systems of medicine. MATERIALS AND METHODS: The methanol extract of seeds of Z. jujuba was partitioned into petroleum ether and water soluble fractions. Isolation of compounds was performed by silica gel column chromatography. The structures of isolated compounds were established on the basis of spectral studies and chemical reactions...
January 2017: Journal of Pharmacy & Bioallied Sciences
Fernanda Carolina Sousa Fonseca, Letícia Caribé Batista Reis, Jener David Gonçalves Dos Santos, Carla Rodrigues Cardoso Branco, Sergio Luis da Costa Ferreira, Jorge Mauricio David, Alexsandro Branco
BACKGROUND: The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. MATERIALS AND METHODS: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA...
April 2017: Pharmacognosy Magazine
Babar Murtaza, Meryem Berrichi, Chahid Bennamar, Thierry Tordjmann, Fatima Z Djeziri, Aziz Hichami, Julia Leemput, Meriem Belarbi, Hakan Ozdener, Naim A Khan
Zizyphin, isolated from Zizyphus sps. leaf extracts, has been shown to modulate sugar taste perception, and the palatability of a sweet solution is increased by the addition of fatty acids. We, therefore, studied whether zizyphin also modulates fat taste perception. Zizyphin was purified from edible fruit of Zizyphus lotus L. Zizyphin-induced increases in [Ca(2+) ]i in human taste bud cells (hTBC). Zizyphin shared the endoplasmic reticulum Ca(2+) pool and also recruited, in part, Ca(2+) from extracellular environment via the opening of store-operated Ca(2+) channels...
April 2, 2017: Fundamental & Clinical Pharmacology
Murad A Mubaraki, Taghreed A Hafiz, Saleh Al-Quraishy, Mohamed A Dkhil
The development and spread of multidrug-resistant strains of malarial parasites have led to an overwhelming increase in the resistance to current antimalarial drugs. The urgent need for alternative antimalarial drugs has directed some of the current studies toward folkloric medicine approaches. Interestingly, the Zizyphus spina Cristi leaf extract (ZLE) has been found to exhibit antiplasmodial activity. This study evaluated the protective effect of ZLE against Plasmodium berghei-induced cerebral tissue injuries in mice...
March 21, 2017: Microbial Pathogenesis
Jirapast Sichaem, Thammarat Aree, Kiattisak Lugsanangarm, Santi Tip-Pyang
CONTEXT: Previous studies have shown that extracts of Zizyphus rugosa Lam. (Rhamnaceae) bark contained phytoconstituents with antidiabetic potential to lower blood glucose levels in diabetic rats. However, there has been no report on the active compounds in this plant as potential antidiabetic inhibitors. OBJECTIVE: We evaluated the α-glucosidase inhibitory and antioxidant activities of Z. rugosa extract. Moreover, the active phytochemical constituents were isolated and characterized...
December 2017: Pharmaceutical Biology
Kyo Bin Kang, Hyun Woo Kim, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Three unprecedented ceanothane-type triterpenoids, ent-epicatechinoceanothic acid A (1), ent-epicatechinoceanothic acid B (2), and epicatechino-3-deoxyceanothetric acid A (3), containing C-C bond linkages with catechin moieties, were isolated from the roots of Zizyphus jujuba. Their chemical structures, including absolute configurations, were established by spectroscopic analysis and calculation of their ECD spectra. A possible biogenetic pathway for C-C bond formation between the catechin and the triterpenoid moieties is presented...
April 28, 2017: Journal of Natural Products
Andrew Scholey, Sarah Benson, Amy Gibbs, Naomi Perry, Jerome Sarris, Greg Murray
Acute, non-clinical insomnia is not uncommon. Sufferers commonly turn to short-term use of herbal supplements to alleviate the symptoms. This placebo-controlled, double-blind study investigated the efficacy of LZComplex3 (lactium™, Zizyphus, Humulus lupulus, magnesium and vitamin B6), in otherwise healthy adults with mild insomnia. After a 7-day single-blind placebo run-in, eligible volunteers (n = 171) were randomized (1:1) to receive daily treatment for 2 weeks with LZComplex3 or placebo. Results revealed that sleep quality measured by change in Pittsburgh Sleep Quality Index (PSQI) score improved in both the LZComplex3 and placebo groups...
February 17, 2017: Nutrients
So Yeon Jo, In Ho Jung, Jee Hyun Yi, Tae Joon Choi, Seungheon Lee, Ji Wook Jung, Jeanho Yun, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
ETHNOPHARMACOLOGICAL RELEVANCE: As the seed of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) has been used to sleep disturbances in traditional Chinese and Korean medicine, many previous studies have focused on its sedative effect. AIM OF THE STUDY: Recently, we reported the neuroprotective effect of the effect of Z. jujuba var. spinosa. However, its effects on synaptic function have not yet been studied. In this project, we examined the action of ethanol extract of the seed of Z...
March 22, 2017: Journal of Ethnopharmacology
Li Zhang, Xinquan Liu, Yongjie Wang, Guangpu Liu, Zhen Zhang, Zhongxi Zhao, Huiling Cheng
Zizyphus jujuba has been used as a traditional Chinese medicinal herb since ancient time. Polysaccharides have been found to be important bioactive compounds in the jujube. This work was designed to investigate the physicochemical characteristics and bioactivities of polysaccharides purified from Zizyphus jujuba cv. Muzao. Water-soluble polysaccharides were extracted using an ultrasonically assisted extraction method. The purified polysaccharides (HJP) were obtained by deproteinization and decoloration. Three main fractions (HJP1, HJP2 and HJP3) were isolated using DEAE-Sepharose fast flow ion-exchange chromatography...
February 2017: International Journal of Biological Macromolecules
Danilo Cavalcanti Gomes, Hélimar Gonçalves de Lima, Ariádne Vieira Vaz, Nathália Silva Santos, Francianne Oliveira Santos, Êuder Reis Dias, Mariana Borges Botura, Alexsandro Branco, Maria José Moreira Batatinha
This study examined the in vitro effect of the Zizyphus joazeiro bark against gastrointestinal nematodes of goats and its cytotoxicity on Vero cells. The ovicidal activity of the crude hydroethanolic extract (CE), its partitioned hexane (HE) and aqueous extract (AE) and saponins fraction (SF), including betulinic acid (BA), a biogenetic compound from this plant found in HE, were investigated using the inhibition of egg hatch assay (EHA). Thereafter, the extracts and the SF were evaluated through the larval motility assay (LMA) and larval migration inhibition assay (LMIA)...
August 15, 2016: Veterinary Parasitology
Sangeetha Gupta, Yogendra Kumar Gupta
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, Zizyphus jujuba is used for anticonvulsant, hypnotic-sedative, anxiolytic, tranquilizer, antioxidant and anti-inflammatory properties. Likewise silymarin is popularly used for its potent antioxidant and hepatoprotective effects. Stroke being a multifactorial disease with unsatisfactory treatment outcomes, necessitates development of multimodal therapeutic interventions. Thus, we evaluated the therapeutic benefits of herbal combination of Z...
February 2, 2017: Journal of Ethnopharmacology
Somaye Alvani, Esmat Mahdikhani-Moghadam, Hamid Rouhani, Abbas Mohammadi, Gerrit Karssen
In order to identify plant-parasitic nematodes (family Tylenchidae Örley 1880) associated with Ziziphus zizyphus in Iran, 360 soil and root samples were collected from South Khorasan province during 2012-2014. Herein, a new species of Basiria and several known members of the family Tylenchidae are reported. B. birjandiensis n. sp. is characterized by short body length (584-748 µm [660.6±72.3]), lip region with flat apex, stylet 11-12 µm (11.3±0.5), excretory pore position varying from isthmus level to the middle of the basal bulb (78-91 µm from the anterior end of the body), post-vulval uterine sac 8-14 µm (10...
March 3, 2016: Zootaxa
Khaoula Mkadmini Hammi, Majdi Hammami, Christophe Rihouey, Didier Le Cerf, Riadh Ksouri, Hatem Majdoub
Response surface methodology using a Box-Behnken design was employed to optimize extraction temperature, extraction time and ratio of water to material to obtain a maximum polysaccharide yield with high uronic acid content and antioxidant property from edible Zizyphus lotus fruit. The optimal conditions were: extraction time of 3h 15min, extraction temperature of 91.2°C and water to solid ratio of 39mL/g. Under these conditions, the experimental extraction yield, uronic acid content and 2,2-diphenyl-1-picrylhydrazyl scavenging ability (IC50) were 18...
December 1, 2016: Food Chemistry
Mohamed Abdulraheem Shaheen, Fathy Saad El-Nakhlawy, Fahd Mosallam Almehmadi, Muhammad Zahid Ihsan, Abdulmohsin Rajeh Al-Shareef
A field study was carried out near Jeddah Industrial Zone to estimate the leaf impairment, physiological disorders, and air pollutant accumulation potential of Ziziphus tree. The experiment was triplicated in RCBD design with factorial arrangement having seasonality as the main plot and washing as subplot treatments along with the control. Accumulation of heavy metals and micronutrients in plant foliage varied significantly under the influence of seasons and washing treatments. The maximum accumulation of cadmium, chromium, nickel, and lead were perceived in summer season while the minimum was observed in winter...
June 2016: Environmental Monitoring and Assessment
Shihao Sun, Hui Wang, Jianping Xie, Yue Su
BACKGROUND: Jujube extract is commonly used as a food additive and flavoring. The sensory properties of the extract, especially sweetness, are a critical factor determining the product quality and therefore affecting consumer acceptability. Small molecular carbohydrates make major contribution to the sweetness of the jujube extract, and their types and contents in the extract have direct influence on quality of the product. So, an appropriate qualitative and quantitative method for determination of the carbohydrates is vitally important for quality control of the product...
2016: Chemistry Central Journal
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