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https://www.readbyqxmd.com/read/29115535/jujuboside-a-attenuates-norepinephrine-induced-apoptosis-of-h9c2-cardiomyocytes-by-modulating-mapk-and-akt-signaling-pathways
#1
Chang-Rong Wan, Dan-Dan Han, Jian-Qin Xu, Peng Yin, Xiao-Long Xu, Chen Mei, Feng-Hua Liu, Zhao-Fei Xia
Cardiomyocyte apoptosis is closely associated with the pathogenesis of heart failure. Jujuboside A (JUA) is a type of saponin isolated from the seeds of Zizyphus jujuba. In traditional Chinese medicine, it is believed that JUA possesses multiple biological effects, including antianxiety, antioxidant and anti‑inflammatory activities. The present study aimed to evaluate the effects of JUA on norepinephrine (NE)‑induced apoptosis of H9c2 cells and to investigate its underlying mechanisms. Rat H9c2 cardiomyocytes were pretreated with JUA and were then exposed to NE as an in vitro model of myocardial apoptosis...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29017403/protective-effect-of-zizyphus-lotus-jujube-fruits-against-cypermethrin-induced-oxidative-stress-and-neurotoxicity-in-mice
#2
Khazri Abdelhafidh, Lazher Mhadhbi, Ali Mezni, Sellami Badreddine, Hamouda Beyrem, Ezzeddine Mahmoudi
CONTEXT: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms Objective: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice. MATERIALS AND METHODS: Mice were divided into four groups of six each: groups I and II were used as control and CYP control (20mg/kg body weight)...
October 11, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28948417/vegetation-ecology-and-carbon-sequestration-potential-of-shrubs-in-tropics-of-chhattisgarh-india
#3
Manoj Kumar Jhariya
Tropical forests are well known to have great species diversity and contribute substantial share in terrestrial carbon (C) stocks worldwide. Shrubs are long-neglected life form in the forest ecosystem, playing many roles in the forest and human life. Shrub has great impact on vegetation attributes which in turn modify the C storage and capture. In the present investigation, an attempt has been made to explore the dynamics of shrub species in four fire regimes, viz. high, medium, low, and no fire zones of Bhoramdeo Wildlife Sanctuary of Kawardha forest division (Chhattisgarh), India...
September 25, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28882039/metabolic-profiling-on-alternaria-toxins-and-components-of-xinjiang-jujubes-incubated-with-pathogenic-alternaria-alternata-and-alternaria-tenuissima-via-orbitrap-high-resolution-mass-spectrometry
#4
Dongqiang Hu, Yingying Fan, Yanglan Tan, Ye Tian, Na Liu, Lan Wang, Duoyong Zhao, Cheng Wang, Aibo Wu
Xinjiang jujubes (Zizyphus rhamnaceae) are important agro-economical foods with the highest planting area and yields in China; however, black spot disease and contaminated Alternaria toxins have unfortunately caused a decline or loss of jujube nutritional quality in recent years. In this study, we used ultrahigh-performance liquid chromatography coupled to Orbitrap high-resolution mass spectrometry to profile both Alternaria toxins and components in three representative Xinjiang jujubes, Hami Huang, Hetian Jun, and Ruoqiang Hui...
September 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28832644/3-o-trans-p-coumaroyl-alphitolic-acid-a-triterpenoid-from-zizyphus-jujuba-leads-to-apoptotic-cell-death-in-human-leukemia-cells-through-reactive-oxygen-species-production-and-activation-of-the-unfolded-protein-response
#5
Yohei Mitsuhashi, Yukihiro Furusawa, Tadashi Aradate, Qing-Li Zhao, Rohan Moniruzzaman, Masahiko Kanamori, Kyo Noguchi, Takashi Kondo
3-O-trans-p-coumaroyl-alphitolic acid (3OTPCA), a triterpenoid isolated from the plant Zizyphus jujuba (ZJ), is known to be cytotoxic to cancer cells; however, the molecular mechanism underlying 3OTPCA-induced cell death remains unknown. Here, we provide novel evidence that 3OTPCA induces apoptotic cell death in human leukemia cells. We found that 3OPTCA induces DNA fragmentation within 24 h after treatment in U937 cells, which was also observed in other leukemia cell lines, including Molt-4 and Jurkat cells...
2017: PloS One
https://www.readbyqxmd.com/read/28698081/in-vitro-immunological-and-anti-complementary-activities-of-two-water-soluble-lignins-from-zizyphus-jujube-cv-jinchangzao
#6
Yuqing Cai, Xinping Zhou, Aizhi Han, Peng Chen, Hongjin Bai
Two homogenous biological macromolecules, designated as JJC1 and JJC2 were extracted from Zizyphus jujube cv. Jinchangzao. Their molecular weights were determined to be 56.03 and 112.11kDa by high performance gel permeation chromatography (HPGPC), respectively. Chemical and spectral analysis indicated that both JJC1 and JJC2 mainly consisted of lignin, along with carbohydrates (∼18%). Both JJC1 and JJC2 could stimulate the proliferation of spleen lymphocytes, and enhance phagocytosis and NO production of RAW264...
December 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28665515/effect-of-harvest-drying-and-storage-on-the-bitterness-moisture-sugars-free-amino-acids-and-phenolic-compounds-of-jujube-fruit-zizyphus-jujuba-cv-junzao
#7
Pu Yunfeng, Tian Ding, Wang Wenjun, Xiang Yanju, Xingqian Ye, Li Mei, Donghong Liu
BACKGROUND: The taste of dried jujube fruit when compared with fresh one is less palatable, as it developed bitterness during drying and storage. Therefore, the revelation of bitterness formation is essential for developing strategies for processing and storage. RESULTS: Bitterness in fresh jujube fruit was negligible, however, increased by 0.9, 1.5 and 1.8 folds during drying and storage over 6 and 12 months. The moisture significantly decreased during harvesting and drying...
June 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28652183/genome-wide-identification-and-characterization-of-the-spl-gene-family-in-ziziphus-jujuba
#8
Fenjuan Shao, Qiang Lu, Iain W Wilson, Deyou Qiu
SQUAMOSA Promoter-Binding Protein-Likes (SPLs) are plant specific transcription factors playing important roles in plant growth and development. The SPL gene family has been studied in various plant species; however, there is no report about SPLs in Zizyphus jujuba. In this study, we identified 18 putative ZjSPL genes in Z. jujuba using a genome-wide analysis. Sequence features, gene structures, conserved domains and motifs were analyzed. The phylogenetic relationships of SPLs in Z. jujuba and A. thaliana were revealed...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28584490/chromatographic-isolation-and-spectroscopic-identification-of-phytoconstituents-of-jujuba-seeds-zizyphus-jujuba-mill
#9
Md Manowwar Alam, Abuzer Ali, Mohammad Ali, Showkat R Mir
BACKGROUND: The seeds of Zizyphus jujuba Mill. (Rhamnaceae) are astringent, aphrodisiac, tonic; used to cure cough, asthma, vomiting, burning sensation, biliousness, leucorrhoea, and eye infections in traditional systems of medicine. MATERIALS AND METHODS: The methanol extract of seeds of Z. jujuba was partitioned into petroleum ether and water soluble fractions. Isolation of compounds was performed by silica gel column chromatography. The structures of isolated compounds were established on the basis of spectral studies and chemical reactions...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28539712/betulinic-acid-from-zizyphus-joazeiro-bark-using-focused-microwave-assisted-extraction-and-response-surface-methodology
#10
Fernanda Carolina Sousa Fonseca, Letícia Caribé Batista Reis, Jener David Gonçalves Dos Santos, Carla Rodrigues Cardoso Branco, Sergio Luis da Costa Ferreira, Jorge Mauricio David, Alexsandro Branco
BACKGROUND: The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. MATERIALS AND METHODS: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28370265/zizyphin-modulates-calcium-signalling-in-human-taste-bud-cells-and-fat-taste-perception-in-the-mouse
#11
Babar Murtaza, Meryem Berrichi, Chahid Bennamar, Thierry Tordjmann, Fatima Z Djeziri, Aziz Hichami, Julia Leemput, Meriem Belarbi, Hakan Ozdener, Naim A Khan
Zizyphin, isolated from Zizyphus sps. leaf extracts, has been shown to modulate sugar taste perception, and the palatability of a sweet solution is increased by the addition of fatty acids. We, therefore, studied whether zizyphin also modulates fat taste perception. Zizyphin was purified from edible fruit of Zizyphus lotus L. Zizyphin-induced increases in [Ca(2+) ]i in human taste bud cells (hTBC). Zizyphin shared the endoplasmic reticulum Ca(2+) pool and also recruited, in part, Ca(2+) from extracellular environment via the opening of store-operated Ca(2+) channels...
April 2, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28336326/oxidative-stress-and-genes-regulation-of-cerebral-malaria-upon-zizyphus-spina-christi-treatment-in-a-murine-model
#12
Murad A Mubaraki, Taghreed A Hafiz, Saleh Al-Quraishy, Mohamed A Dkhil
The development and spread of multidrug-resistant strains of malarial parasites have led to an overwhelming increase in the resistance to current antimalarial drugs. The urgent need for alternative antimalarial drugs has directed some of the current studies toward folkloric medicine approaches. Interestingly, the Zizyphus spina Cristi leaf extract (ZLE) has been found to exhibit antiplasmodial activity. This study evaluated the protective effect of ZLE against Plasmodium berghei-induced cerebral tissue injuries in mice...
March 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28320255/identification-of-highly-potent-%C3%AE-glucosidase-inhibitory-and-antioxidant-constituents-from-zizyphus-rugosa-bark-enzyme-kinetic-and-molecular-docking-studies-with-active-metabolites
#13
COMPARATIVE STUDY
Jirapast Sichaem, Thammarat Aree, Kiattisak Lugsanangarm, Santi Tip-Pyang
CONTEXT: Previous studies have shown that extracts of Zizyphus rugosa Lam. (Rhamnaceae) bark contained phytoconstituents with antidiabetic potential to lower blood glucose levels in diabetic rats. However, there has been no report on the active compounds in this plant as potential antidiabetic inhibitors. OBJECTIVE: We evaluated the α-glucosidase inhibitory and antioxidant activities of Z. rugosa extract. Moreover, the active phytochemical constituents were isolated and characterized...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28257196/catechin-bound-ceanothane-type-triterpenoid-derivatives-from-the-roots-of-zizyphus-jujuba
#14
Kyo Bin Kang, Hyun Woo Kim, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Three unprecedented ceanothane-type triterpenoids, ent-epicatechinoceanothic acid A (1), ent-epicatechinoceanothic acid B (2), and epicatechino-3-deoxyceanothetric acid A (3), containing C-C bond linkages with catechin moieties, were isolated from the roots of Zizyphus jujuba. Their chemical structures, including absolute configurations, were established by spectroscopic analysis and calculation of their ECD spectra. A possible biogenetic pathway for C-C bond formation between the catechin and the triterpenoid moieties is presented...
April 28, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28218661/exploring-the-effect-of-lactium%C3%A2-and-zizyphus-complex-on-sleep-quality-a-double-blind-randomized-placebo-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Andrew Scholey, Sarah Benson, Amy Gibbs, Naomi Perry, Jerome Sarris, Greg Murray
Acute, non-clinical insomnia is not uncommon. Sufferers commonly turn to short-term use of herbal supplements to alleviate the symptoms. This placebo-controlled, double-blind study investigated the efficacy of LZComplex3 (lactium™, Zizyphus, Humulus lupulus, magnesium and vitamin B6), in otherwise healthy adults with mild insomnia. After a 7-day single-blind placebo run-in, eligible volunteers (n = 171) were randomized (1:1) to receive daily treatment for 2 weeks with LZComplex3 or placebo. Results revealed that sleep quality measured by change in Pittsburgh Sleep Quality Index (PSQI) score improved in both the LZComplex3 and placebo groups...
February 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28167293/ethanol-extract-of-the-seed-of-zizyphus-jujuba-var-spinosa-potentiates-hippocampal-synaptic-transmission-through-mitogen-activated-protein-kinase-adenylyl-cyclase-and-protein-kinase-a-pathways
#16
So Yeon Jo, In Ho Jung, Jee Hyun Yi, Tae Joon Choi, Seungheon Lee, Ji Wook Jung, Jeanho Yun, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
ETHNOPHARMACOLOGICAL RELEVANCE: As the seed of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) has been used to sleep disturbances in traditional Chinese and Korean medicine, many previous studies have focused on its sedative effect. AIM OF THE STUDY: Recently, we reported the neuroprotective effect of the effect of Z. jujuba var. spinosa. However, its effects on synaptic function have not yet been studied. In this project, we examined the action of ethanol extract of the seed of Z...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27815124/in-vitro-antioxidative-and-immunological-activities-of-polysaccharides-from-zizyphus-jujuba-cv-muzao
#17
Li Zhang, Xinquan Liu, Yongjie Wang, Guangpu Liu, Zhen Zhang, Zhongxi Zhao, Huiling Cheng
Zizyphus jujuba has been used as a traditional Chinese medicinal herb since ancient time. Polysaccharides have been found to be important bioactive compounds in the jujube. This work was designed to investigate the physicochemical characteristics and bioactivities of polysaccharides purified from Zizyphus jujuba cv. Muzao. Water-soluble polysaccharides were extracted using an ultrasonically assisted extraction method. The purified polysaccharides (HJP) were obtained by deproteinization and decoloration. Three main fractions (HJP1, HJP2 and HJP3) were isolated using DEAE-Sepharose fast flow ion-exchange chromatography...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27514875/in-vitro-anthelmintic-activity-of-the-zizyphus-joazeiro-bark-against-gastrointestinal-nematodes-of-goats-and-its-cytotoxicity-on-vero-cells
#18
Danilo Cavalcanti Gomes, Hélimar Gonçalves de Lima, Ariádne Vieira Vaz, Nathália Silva Santos, Francianne Oliveira Santos, Êuder Reis Dias, Mariana Borges Botura, Alexsandro Branco, Maria José Moreira Batatinha
This study examined the in vitro effect of the Zizyphus joazeiro bark against gastrointestinal nematodes of goats and its cytotoxicity on Vero cells. The ovicidal activity of the crude hydroethanolic extract (CE), its partitioned hexane (HE) and aqueous extract (AE) and saponins fraction (SF), including betulinic acid (BA), a biogenetic compound from this plant found in HE, were investigated using the inhibition of egg hatch assay (EHA). Thereafter, the extracts and the SF were evaluated through the larval motility assay (LMA) and larval migration inhibition assay (LMIA)...
August 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27452658/combination-of-zizyphus-jujuba-and-silymarin-showed-better-neuroprotective-effect-as-compared-to-single-agent-in-mcao-induced-focal-cerebral-ischemia-in-rats
#19
Sangeetha Gupta, Yogendra Kumar Gupta
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, Zizyphus jujuba is used for anticonvulsant, hypnotic-sedative, anxiolytic, tranquilizer, antioxidant and anti-inflammatory properties. Likewise silymarin is popularly used for its potent antioxidant and hepatoprotective effects. Stroke being a multifactorial disease with unsatisfactory treatment outcomes, necessitates development of multimodal therapeutic interventions. Thus, we evaluated the therapeutic benefits of herbal combination of Z...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27394308/description-of-basiria-birjandiensis-n-sp-nematoda-tylenchidae-%C3%A2-from-south-khorasan-province-with-a-checklist-of-the-family-tylenchidae-%C3%A3-rley-1880-from-iran
#20
Somaye Alvani, Esmat Mahdikhani-Moghadam, Hamid Rouhani, Abbas Mohammadi, Gerrit Karssen
In order to identify plant-parasitic nematodes (family Tylenchidae Örley 1880) associated with Ziziphus zizyphus in Iran, 360 soil and root samples were collected from South Khorasan province during 2012-2014. Herein, a new species of Basiria and several known members of the family Tylenchidae are reported. B. birjandiensis n. sp. is characterized by short body length (584-748 µm [660.6±72.3]), lip region with flat apex, stylet 11-12 µm (11.3±0.5), excretory pore position varying from isthmus level to the middle of the basal bulb (78-91 µm from the anterior end of the body), post-vulval uterine sac 8-14 µm (10...
March 3, 2016: Zootaxa
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