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Danilo Cavalcanti Gomes, Hélimar Gonçalves de Lima, Ariádne Vieira Vaz, Nathália Silva Santos, Francianne Oliveira Santos, Êuder Reis Dias, Mariana Borges Botura, Alexsandro Branco, Maria José Moreira Batatinha
This study examined the in vitro effect of the Zizyphus joazeiro bark against gastrointestinal nematodes of goats and its cytotoxicity on Vero cells. The ovicidal activity of the crude hydroethanolic extract (CE), its partitioned hexane (HE) and aqueous extract (AE) and saponins fraction (SF), including betulinic acid (BA), a biogenetic compound from this plant found in HE, were investigated using the inhibition of egg hatch assay (EHA). Thereafter, the extracts and the SF were evaluated through the larval motility assay (LMA) and larval migration inhibition assay (LMIA)...
August 15, 2016: Veterinary Parasitology
Sangeetha Gupta, Yogendra Kumar Gupta
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, Zizyphus jujuba is used for anticonvulsant, hypnotic-sedative, anxiolytic, tranquilizer, antioxidant and anti-inflammatory properties. Likewise silymarin is popularly used for its potent antioxidant and hepatoprotective effects. Stroke being a multifactorial disease with unsatisfactory treatment outcomes, necessitates development of multimodal therapeutic interventions. Thus, we evaluated the therapeutic benefits of herbal combination of Zizyphus jujuba and silymarin in a focal cerebral ischemia model...
July 21, 2016: Journal of Ethnopharmacology
Somaye Alvani, Esmat Mahdikhani-Moghadam, Hamid Rouhani, Abbas Mohammadi, Gerrit Karssen
In order to identify plant-parasitic nematodes (family Tylenchidae Örley 1880) associated with Ziziphus zizyphus in Iran, 360 soil and root samples were collected from South Khorasan province during 2012-2014. Herein, a new species of Basiria and several known members of the family Tylenchidae are reported. B. birjandiensis n. sp. is characterized by short body length (584-748 µm [660.6±72.3]), lip region with flat apex, stylet 11-12 µm (11.3±0.5), excretory pore position varying from isthmus level to the middle of the basal bulb (78-91 µm from the anterior end of the body), post-vulval uterine sac 8-14 µm (10...
2016: Zootaxa
Khaoula Mkadmini Hammi, Majdi Hammami, Christophe Rihouey, Didier Le Cerf, Riadh Ksouri, Hatem Majdoub
Response surface methodology using a Box-Behnken design was employed to optimize extraction temperature, extraction time and ratio of water to material to obtain a maximum polysaccharide yield with high uronic acid content and antioxidant property from edible Zizyphus lotus fruit. The optimal conditions were: extraction time of 3h 15min, extraction temperature of 91.2°C and water to solid ratio of 39mL/g. Under these conditions, the experimental extraction yield, uronic acid content and 2,2-diphenyl-1-picrylhydrazyl scavenging ability (IC50) were 18...
December 1, 2016: Food Chemistry
Mohamed Abdulraheem Shaheen, Fathy Saad El-Nakhlawy, Fahd Mosallam Almehmadi, Muhammad Zahid Ihsan, Abdulmohsin Rajeh Al-Shareef
A field study was carried out near Jeddah Industrial Zone to estimate the leaf impairment, physiological disorders, and air pollutant accumulation potential of Ziziphus tree. The experiment was triplicated in RCBD design with factorial arrangement having seasonality as the main plot and washing as subplot treatments along with the control. Accumulation of heavy metals and micronutrients in plant foliage varied significantly under the influence of seasons and washing treatments. The maximum accumulation of cadmium, chromium, nickel, and lead were perceived in summer season while the minimum was observed in winter...
June 2016: Environmental Monitoring and Assessment
Shihao Sun, Hui Wang, Jianping Xie, Yue Su
BACKGROUND: Jujube extract is commonly used as a food additive and flavoring. The sensory properties of the extract, especially sweetness, are a critical factor determining the product quality and therefore affecting consumer acceptability. Small molecular carbohydrates make major contribution to the sweetness of the jujube extract, and their types and contents in the extract have direct influence on quality of the product. So, an appropriate qualitative and quantitative method for determination of the carbohydrates is vitally important for quality control of the product...
2016: Chemistry Central Journal
Rui Jiao, Yingxia Liu, Hao Gao, Jia Xiao, Kwok Fai So
Oxidative stress has been increasingly recognized as a major contributing factor in a variety of human diseases, from inflammation to cancer. Although certain parts of signaling pathways are still under investigation, detailed molecular mechanisms for the induction of diseases have been elucidated, especially the link between excessive oxygen reactive species (ROS) damage and tumorigenesis. Emerging evidence suggests anti-oxidant therapy can play a key role in treating those diseases. Among potential drug resources, plant polysaccharides are natural anti-oxidant constituents important for human health because of their long history in ethnopharmacology, wide availability and few side effects upon consumption...
2016: American Journal of Chinese Medicine
Younghwan Lee, Se Jin Jeon, Hyung Eun Lee, In Ho Jung, Yeong-Woo Jo, Sunhee Lee, Jae Hoon Cheong, Dae Sik Jang, Jong Hoon Ryu
Adult neurogenesis has received much attention due to its potential role in neurological or psychiatric disorders such as Alzheimer's disease. In the present study, we examined whether spinosin, a C-glycoside flavonoid from the seeds of Zizyphus jujuba var. spinosa, affects cognitive performance and adult hippocampal neurogenesis in normal naïve mice. The subchronic administration of spinosin (5mg/kg) for 14days significantly increased the latency time in the passive avoidance task. Doublecortin and 5-bromo-2-deoxyuridine immunostaining revealed that the subchronic administration of spinosin (5mg/kg) significantly increased the proliferation and survival of neuronal cells and the number of immature neurons in the hippocampal dentate gyrus region...
June 2016: Pharmacology, Biochemistry, and Behavior
Zhuo-ping Yu, Dong-dong Xu, Lai-feng Lu, Xiao-dong Zheng, Wei Chen
BACKGROUND: American ginseng (Panax quinquefolius L.) and Chinese jujube (Zizyphus jujuba Mill.) are commonly used in traditional Chinese medicine to enhance immune function. OBJECTIVE: The present study aimed to develop one Chinese prescription, Shenzao Cha (SZC), consisting of American ginseng and Chinese jujube, and systematically investigate its immunomodulation in healthy ICR mice. METHODS: Normal ICR mice received intragastric administration of SZC (1...
February 2016: Journal of Zhejiang University. Science. B
Farhana Mazhar, Raisa Khanum, Muhammad Ajaib, Muhammad Jahangir
The purpose of this study was to assess the antioxidant potential and enzyme inhibition of various fractions of Zizyphus oxyphylla. The plant metabolites were extracted in methanol and partitioned with n-hexane, chloroform, ethyl acetate and n-butanol successively. Phytochemical screening showed presence of alkaloids, terpenoids and flavonoids in ethyl acetate and n-butanol fractions. The antioxidant potential and acetylcholine esterase assay of all these fractions and remaining aqueous fraction was evaluated by using reported methods...
November 2015: Pakistan Journal of Pharmaceutical Sciences
Cancan Wang, Chuanrong Li, Charles A Leslie, Qingrong Sun, Xianfeng Guo, Keqiang Yang
Tocopherol cyclase (VTE1) plays a key role in promoting the production of γ-tocopherol and improving total tocopherol content in photosynthetic organisms. Walnut is an important source of tocopherols in the human diet, and γ-tocopherol is the major tocopherol compound in walnut kernels. In this study, a full-length cDNA of the VTE1 gene was isolated from walnut using RT-PCR and RACE, and designated as JrVTE1. The full-length cDNA of the JrVTE1 gene contained a 1353-bp open-reading frame encoding a 451-amino-acid protein with a calculated molecular weight of 49...
2015: Molecular Breeding: New Strategies in Plant Improvement
Sarbani Dey Ray, Supratim Ray, Muhammad Zia-Ul-Haq, Vincenzo De Feo, Saikat Dewanjee
BACKGROUND: The root bark of Zizyphus nummularia (Rhamnaceae) is traditionally used as an anti-inflammatory agent. The current study aimed to explore the anti-inflammatory activity (in vivo) of a crude ethanolic extract (EE) and the pure identified octadecahydro-picene-2,3,14,15-tetranone (IC) in the root bark of Z. nummularia. IC was further subjected to suitable in vitro and in silico studies to find out the mechanistic pharmacology. METHODS: EE (100 and 200 mg/kg, p...
2015: BMC Complementary and Alternative Medicine
Ying Guo, Yongnian Ni, Serge Kokot
Near-infrared spectroscopy (NIRS) calibrations were developed for the discrimination of spectra of the jujube (Zizyphus jujuba Mill.) fruit samples from four geographical regions. Prediction models were developed for the quantitative prediction of the contents of jujube fruit, i.e., total sugar, total acid, total phenolic content, and total antioxidant activity. Four pattern recognition methods, principal component analysis (PCA), linear discriminant analysis (LDA), least squares-support vector machines (LS-SVM), and back propagation-artificial neural networks (BP-ANN), were used for the geographical origin classification...
January 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Suhas Talmale, Arti Bhujade, Mandakini Patil
An allergy may sometimes be very dangerous and one of the main factors responsible for allergy is the complement system which can lead to a life-threatening reaction called anaphylaxis. Cycloxygenase-1 (COX-1), Cycloxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) trigger allergic and inflammatory reactions. A number of anti-allergic synthetic drugs are available but are costly and show many side effects. Hence, the ancient traditional system of medication mentioned in Ayurveda finds an edge over various synthetic drugs...
September 2015: Food & Function
Eun-Hye Hong, Jae Hyoung Song, Kyo Bin Kang, Sang Hyun Sung, Hyun-Jeong Ko, Heejung Yang
Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on influenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-influenza viral activity at a concentration of 50 μM without a significant cytotoxicity in influenza A/PR/8 virus infected A549 cells...
July 2015: Biomolecules & Therapeutics
Omid Koohi-Hosseinabadi, Azadeh Andisheh-Tadbir, Parisa Bahadori, Masood Sepehrimanesh, Maryam Mardani, Nader Tanideh
BACKGROUND: Oral mucositis (OM) is a common inflammatory complication among cancerous patients as an adverse effect of chemotherapy and radiotherapy. The aim of this study was to evaluate the effects and identify the appropriate route of administration of extract of Zizyphus jujuba in 5-flurouracile induced OM induction in golden hamster. MATERIAL AND METHODS: In a prospective randomized double blind animal study, OM was induced in 56 male golden hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study...
April 2015: Journal of Clinical and Experimental Dentistry
Ayat Kaeidi, Majid Taati, Zahra Hajializadeh, Faranak Jahandari, Marzieh Rashidipour
OBJECTIVES: The neuroprotective effect of fruit aqueous extract of Ziziphus jujuba Lam on glucose-induced neurotoxicity in PC12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. MATERIALS AND METHODS: Cell viability was determined by the MTT assay. Cellular reactive oxygen species (ROS) generation was measured by DCFH-DA analysis. Cleaved caspase-3, a biochemical parameter of cellular apoptosis, was measured by western blot analysis...
March 2015: Iranian Journal of Basic Medical Sciences
C Kavitha, Aparna Kuna, T Supraja, S Blessy Sagar, T V N Padmavathi, Neeraja Prabhakar
Effect of gamma irradiation (0.25 to 1.0kGy) on antioxidant properties of ber fruit was studied. Antioxidant properties of ber fruits were determined by Scavenging DPPH radical activity, reducing power assay, super oxide anion radical activity, TBARS, total phenolic content and total flavonoid content. Gamma irradiation treatment up to 1.0kGy elevated the Scavenging DPPH radical activity (9 %), super oxide anion radical activity (26 %) and total flavonoid content (208 %) compared to fresh ber fruit. On the other hand it brought down the reducing power activity (65 %) and total phenolic content (18 %) as compared to raw fruit...
May 2015: Journal of Food Science and Technology
Khaoula Mkadmini Hammi, Ahmed Jdey, Chedly Abdelly, Hatem Majdoub, Riadh Ksouri
The optimization of antioxidant extraction conditions from a ripe edible fruits of Zizyphus lotus (L.) with an ultrasound-assisted system was achieved by response surface methodology. The central composite rotatable design was employed for optimization of extraction parameters in terms of total phenolic content and antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and phosphomolybdenum assay. The optimum operating conditions for extraction were as follows: ethanol concentration, 50%; extraction time, 25 min; extraction temperature, 63°C and ratio of solvent to solid, 67 mL/g...
October 1, 2015: Food Chemistry
Sang Yoon Ko, Hyung Eun Lee, Se Jin Park, Se Jin Jeon, Boseong Kim, Qingtao Gao, Dae Sik Jang, Jong Hoon Ryu
Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var...
March 2015: Biomolecules & Therapeutics
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