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cod liver oil

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https://www.readbyqxmd.com/read/29118465/antioxidant-and-anti-inflammatory-activities-in-extracts-from-minke-whale-balaenoptera-acutorostrata-blubber
#1
Mari Johannessen Walquist, Svein Kristian Stormo, Ida-Johanne Jensen, Bjarne Østerud, Karl-Erik Eilertsen
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory and CVD risk markers compared to CLO. In the present study, we prepared virtually lipid-free extracts from CWO and CLO and evaluated the antioxidative capacity (AOC) and anti-inflammatory effects...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29113061/effects-of-marine-oils-digested-with-human-fluids-on-cellular-viability-and-stress-protein-expression-in-human-intestinal-caco-2-cells
#2
Cecilia Tullberg, Gerd Vegarud, Ingrid Undeland, Nathalie Scheers
In vitro digestion of marine oils has been reported to promote lipid oxidation, including the formation of reactive aldehydes (e.g., malondialdehyde (MDA) and 4-hydroxy-2-hexenal (HHE)). We aimed to investigate if human in vitro digestion of supplemental levels of oils from algae, cod liver, and krill, in addition to pure MDA and HHE, affect intestinal Caco-2 cell survival and oxidative stress. Cell viability was not significantly affected by the digests of marine oils or by pure MDA and HHE (0-90 μM). Cellular levels of HSP-70, a chaperone involved in the prevention of stress-induced protein unfolding was significantly decreased (14%, 28%, and 14% of control for algae, cod and krill oil, respectively; p ≤ 0...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29048366/lipase-catalyzed-transesterification-of-egg-yolk-phophatidylcholine-with-concentrate-of-n-3-polyunsaturated-fatty-acids-from-cod-liver-oil
#3
Anna Chojnacka, Witold Gładkowski, Aleksandra Grudniewska
Phospholipids containing PUFAs are important vehicles for their delivering to the targeted tissues. In our research project we established enzymatic methods for the enrichment of natural egg-yolk PC with n-3 PUFAs. Instead of synthetic PUFA ethyl esters, the new strategy was developed using polyunsaturated fatty acids enriched fraction (PUFA-EF) from cod liver oil as the natural acyl donors. PUFA-EF was produced by urea-complexation and contained 86.9% PUFA including 8.5% stearidonic acid (SDA; 18:4(n-3)), 26...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29030414/longitudinal-associations-between-marine-omega-3-supplement-users-and-coronary-heart-disease-in-a-uk-population-based-cohort
#4
Marleen A H Lentjes, Ruth H Keogh, Ailsa A Welch, Angela A Mulligan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw
OBJECTIVES: Assess the association between marine omega-3 polyunsaturated fatty acid (n-3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. DESIGN: Prospective cohort study, with three exposure measurements over 22 years. SETTING: Norfolk-based European Prospective Investigation into Cancer (EPIC-Norfolk, UK). PARTICIPANTS: 22 035 men and women from the general population, 39-79 years at recruitment...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28763949/physical-and-oxidative-stability-of-fish-oil-in-water-emulsions-fortified-with-enzymatic-hydrolysates-from-common-carp-cyprinus-carpio-roe
#5
Sakhi Ghelichi, Ann-Dorit Moltke Sørensen, Pedro J García-Moreno, Mona Hajfathalian, Charlotte Jacobsen
Physical and oxidative stability of 5% (by weight) cod liver oil-in-water emulsions fortified with common carp (C. carpio) roe protein hydrolysate (CRPH) were examined. CRPH was obtained by enzymatic hydrolysis of discarded roe by using Alcalase 2.4L for 30, 60, 90, and 120min to yield different degrees of hydrolysis (DH). All the hydrolysates showed in vitro antioxidant activity in terms of radical scavenging and chelating properties. CRPH-containing emulsions had significantly smaller droplets than control (p<0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28756294/vitamin-d-cod-liver-oil-sunshine-and-phototherapy-safe-effective-and-forgotten-tools-for-treating-and-curing-tuberculosis-infections-a-comprehensive-review
#6
REVIEW
Patrick J McCullough, Douglas S Lehrer
Tuberculosis remains an epidemic throughout the world, with over 2 billion people, or more than one third of the world's population, infected with TB. In 2015, there were an estimated 10.4 million new cases of tuberculosis, and 1.8 million deaths, making TB one of the top ten causes of death worldwide. Approximately 95% of new TB cases occur in developing countries, where the costs of treatment force many patients and their families into poverty. The United Nations and the World Health Organization are working to end this global epidemic...
July 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28571624/reprint-of-cyp1a-protein-expression-and-catalytic-activity-in-double-crested-cormorants-experimentally-exposed-to-deepwater-horizon-mississippi-canyon-252-oil
#7
Courtney R Alexander, Michael J Hooper, Dave Cacela, Kim D Smelker, Caleshia S Calvin, Karen M Dean, Steve J Bursian, Fred L Cunningham, Katie C Hanson-Dorr, Katherine E Horak, John P Isanhart, Jane Link, Susan A Shriner, Céline A J Godard-Codding
Double-crested cormorants (Phalacrocorax auritus, DCCO) were orally exposed to Deepwater Horizon Mississippi Canyon 252 (DWH) oil to investigate oil-induced toxicological impacts. Livers were collected for multiple analyses including cytochrome P4501A (CYP1A) enzymatic activity and protein expression. CYP1A enzymatic activity was measured by alkoxyresorufin O-dealkylase (AROD) assays. Activities specific to the O-dealkylation of four resorufin ethers are reported: benzyloxyresorufin O-debenzylase (BROD), ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and pentoxyresorufin O-depentylase (PROD)...
December 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28492305/monitoring-interfacial-lipid-oxidation-in-oil-in-water-emulsions-using-spatially-resolved-optical-techniques
#8
Chiranjib Banerjee, Michael Westberg, Thomas Breitenbach, Mikkel Bregnhøj, Peter R Ogilby
The oxidation of lipids is an important phenomenon with ramifications for disciplines that range from food science to cell biology. The development and characterization of tools and techniques to monitor lipid oxidation are thus relevant. Of particular significance in this regard are tools that facilitate the study of oxidations at interfaces in heterogeneous samples (e.g., oil-in-water emulsions, cell membranes). In this article, we establish a proof-of-principle for methods to initiate and then monitor such oxidations with high spatial resolution...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28490135/polyunsaturated-lipids-and-vitamin-a-oxidation-during-cod-liver-oil-in-vitro-gastrointestinal-digestion-antioxidant-effect-of-added-bht
#9
Bárbara Nieva-Echevarría, Encarnación Goicoechea, María D Guillén
The extent of cod liver oil hydrolysis and oxidation during in vitro gastrointestinal digestion was investigated by Proton Nuclear Magnetic Resonance ((1)H NMR) and Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS). These techniques evidenced the degradation of polyunsaturated ω-3 and ω-6 lipids and, for the first time, that of vitamin A, naturally present in cod liver oil. Cis,trans-conjugated dienes associated with hydroperoxides, as well as monoepoxides, cis,trans-2,4-alkadienals, 4-hydroperoxy- and 4-hydroxy-2-alkenals, and several vitamin A derived metabolites were generated...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28390242/cyp1a-protein-expression-and-catalytic-activity-in-double-crested-cormorants-experimentally-exposed-to-deepwater-horizon-mississippi-canyon-252-oil
#10
Courtney R Alexander, Michael J Hooper, Dave Cacela, Kim D Smelker, Caleshia S Calvin, Karen M Dean, Steve J Bursian, Fred L Cunningham, Katie C Hanson-Dorr, Katherine E Horak, John P Isanhart, Jane Link, Susan A Shriner, Céline A J Godard-Codding
Double-crested cormorants (Phalacrocorax auritus, DCCO) were orally exposed to Deepwater Horizon Mississippi Canyon 252 (DWH) oil to investigate oil-induced toxicological impacts. Livers were collected for multiple analyses including cytochrome P4501A (CYP1A) enzymatic activity and protein expression. CYP1A enzymatic activity was measured by alkoxyresorufin O-dealkylase (AROD) assays. Activities specific to the O-dealkylation of four resorufin ethers are reported: benzyloxyresorufin O-debenzylase (BROD), ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and pentoxyresorufin O-depentylase (PROD)...
April 5, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27892584/a-short-history-of-phototherapy-vitamin-d-and-skin-disease
#11
Paul Jarrett, Robert Scragg
The earliest record between sun exposure and skin disease goes back five millennia to the ancient Egyptians. The modern scientific era of medical light therapy and skin diseases started in 1877 when Downs and Blunt reported that exposure to light inhibited fungal growth in test tubes. Continuing research generated a growing medical interest in the potential the effects of light to treat and cure skin diseases considered as parasitic. This culminated in the awarding of the 1903 Nobel Prize in Medicine to Niels Finsen for his pioneering work showing that light could successfully treat cutaneous mycobacterium tuberculosis (lupus vulgaris), a disfiguring disorder common at the time...
March 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27630989/lack-of-effects-of-a-single-high-fat-meal-enriched-with-vegetable-n-3-or-a-combination-of-vegetable-and-marine-n-3-fatty-acids-on-intestinal-peptide-release-and-adipokines-in-healthy-female-subjects
#12
Ingunn Narverud, Mari C W Myhrstad, Karl-Heinz Herzig, Toni Karhu, Tuva B Dahl, Bente Halvorsen, Stine M Ulven, Kirsten B Holven
Peptides released from the small intestine and colon regulate short-term food intake by suppressing appetite and inducing satiety. Intake of marine omega-3 (n-3) fatty acids (FAs) from fish and fish oils is associated with beneficial health effects, whereas the relation between intake of the vegetable n-3 fatty acid α-linolenic acid and diseases is less clear. The aim of the present study was to investigate the postprandial effects of a single high-fat meal enriched with vegetable n-3 or a combination of vegetable and marine n-3 FAs with their different unsaturated fatty acid composition on intestinal peptide release and the adipose tissue...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27534845/plasma-phospholipid-pentadecanoic-acid-epa-and-dha-and-the-frequency-of-dairy-and-fish-product-intake-in-young-children
#13
Nicolai A Lund-Blix, Kjersti S Rønningen, Håkon Bøås, German Tapia, Lene F Andersen
BACKGROUND: There is a lack of studies comparing dietary assessment methods with the biomarkers of fatty acids in children. OBJECTIVE: The objective was to evaluate the suitability of a food frequency questionnaire (FFQ) to rank young children according to their intake of dairy and fish products by comparing food frequency estimates to the plasma phospholipid fatty acids pentadecanoic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). DESIGN: Cross-sectional data for the present study were derived from the prospective cohort 'Environmental Triggers of Type 1 Diabetes Study'...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27396605/malondialdehyde-and-4-hydroxy-2-hexenal-are-formed-during-dynamic-gastrointestinal-in-vitro-digestion-of-cod-liver-oils
#14
Karin Larsson, Cecilia Tullberg, Marie Alminger, Robert Havenaar, Ingrid Undeland
Marine long-chain polyunsaturated fatty acids (LC n-3 PUFA) are associated with reduced risk for inflammatory diseases, such as cardiovascular diseases and rheumatoid arthritis. These fatty acids, however, are rapidly oxidized, generating highly reactive malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE) and 4-hydroxy-2-nonenal (HNE). These oxidation products may interact with DNA and proteins, thus possibly leading to impaired cell functions. Little is known about the formation of MDA, HHE and HNE in fish oil in the gastrointestinal (GI) tract...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27258290/topical-formulation-comprising-fatty-acid-extract-from-cod-liver-oil-development-evaluation-and-stability-studies
#15
Biljana Ilievska, Thorsteinn Loftsson, Martha Asdis Hjalmarsdottir, Gudrun Marta Asgrimsdottir
The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia...
June 1, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27208797/detoxification-of-hg-ii-from-aqueous-and-enzyme-media-pristine-vs-tailored-calcium-alginate-hydrogels
#16
Kangkana Sarkar, Zarina Ansari, Kamalika Sen
Calcium alginate (CA) hydrogels were tailored using phenolic compounds (PC) like, thymol, morin, catechin, hesperidin, during their preparation. The PC incorporated gels show modified surface features as indicated by scanning electron microscopic images (SEM). The rheological studies show that excepting the hesperidin incorporated gels all the other kinds including calcium alginate pristine have similar mechanical strength. The hesperidine incorporated CA gels had the maximum capacity to adsorb Hg. The Freundlich adsorption isotherms show higher values of adsorption capacity for all PC incorporated CA beads than the pristine CA (PCA)...
October 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27155918/intake-of-a-western-diet-containing-cod-instead-of-pork-alters-fatty-acid-composition-in-tissue-phospholipids-and-attenuates-obesity-and-hepatic-lipid-accumulation-in-mice
#17
Ulrike Liisberg, Kristin Røen Fauske, Ondrej Kuda, Even Fjære, Lene Secher Myrmel, Nina Norberg, Livar Frøyland, Ingvild Eide Graff, Bjørn Liaset, Karsten Kristiansen, Jan Kopecky, Lise Madsen
The content of the marine n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is far lower in lean than in fatty seafood. Cod filets contain less than 2g fat per kg, whereof approximately 50% is EPA and DHA. However, a large fraction of these n-3 PUFAs is present in the phospholipid (PL) fraction and may have high bioavailability and capacity to change the endocannabinoid profile. Here we investigated whether exchanging meat from a lean terrestrial animal with cod in a background Western diet would alter the endocannabinoid tone in mice and thereby attenuate obesity development and hepatic lipid accumulation...
July 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27114101/vitamin-d-deficiency-and-oxidative-stress-in-type-2-diabetic-population-of-india
#18
REVIEW
Yogita Dhas, Neetu Mishra, Joyita Banerjee
Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence of vitamin D deficiency is 70%-100% in the adult population. The main identified reason for vitamin D deficiency is the lack of appropriate sunlight exposure and no consumption (in case of vegetarian population) or less consumption of vitamin D containing diet (e...
2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27007804/various-acylglycerols-from-common-oils-exert-different-antitumor-activities-on-colorectal-cancer-cells
#19
Rebeca P Ramos-Bueno, María J González-Fernández, José L Guil-Guerrero
Colorectal cancer is one of the leading causes of death in Western countries; therefore, the implementation of healthy dietary habits in order to prevent its occurrence is a desirable action. We show here that both free fatty acids (FFAs) and some acylglycerols induce antitumoral actions in the colorectal cancer cell line HT-29. We tested several C18 polyunsaturated fatty acid-enriched oils (e.g., sunflower and Echium) as well as other oils, such as arachidonic acid-enriched (Arasco®) and docosahexaenoic acid-enriched (Marinol® and cod liver oil), in addition to coconut and olive oils...
2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/26999859/-the-detection-of-content-of-diagnostically-significant-fatty-acids-and-individual-triglycerides-in-biological-mediums-based-on-infrared-spectrometry
#20
A V Kalinin, V N Krasheninnikov, A P Sviridov, V N Titov
The content of clinically important fatty acids and individual triglycerides in food and biological mediums are traditionally detected by gas and fluid chromatography in various methodical modifications. The techniques are hard-to-get in laboratories of clinical biochemistry. The study was carried out to develop procedures and equipment for operative quantitative detection of concentration of fatty acids, primarily palmitic saturated fatty acid and oleic mono unsaturated fatty acid. Also detection was applied to sums ofpolyenoic (eicosapentaenoic and docosahexaenoic acid) fatty acids in biological mediums (cod-liver oil, tissues, blood plasma) using spectrometers of short-range infrared band of different types: with Fourier transform, diffraction and combined scattering...
November 2015: Klinicheskaia Laboratornaia Diagnostika
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