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Mei Sun, Ningze Xu, Chengyue Li, Dan Wu, Jiatong Zou, Ying Wang, Li Luo, Mingzhu Yu, Yu Zhang, Hua Wang, Peiwu Shi, Zheng Chen, Jian Wang, Yueliang Lu, Qi Li, Xinhua Wang, Zhenqiang Bi, Ming Fan, Liping Fu, Jingjin Yu, Mo Hao
BACKGROUND: Public health emergencies have challenged the public health emergency management systems (PHEMSs) of many countries critically and frequently since this century. As the world's most populated country and the second biggest economy in the world, China used to have a fragile PHEMS; however, the government took forceful actions to build PHEMS after the 2003 SARS outbreak. After more than one decade's efforts, we tried to assess the improvements and problems of China's PHEMS between 2002 and 2012...
April 11, 2018: BMC Public Health
Buranee Kanchanatawan, Supaksorn Thika, Sunee Sirivichayakul, André F Carvalho, Michel Geffard, Michael Maes
The depression, anxiety and physiosomatic symptoms (DAPS) of schizophrenia are associated with negative symptoms and changes in tryptophan catabolite (TRYCAT) patterning. The aim of this study is to delineate the associations between DAPS and psychosis, hostility, excitation, and mannerism (PHEM) symptoms, cognitive tests as measured using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) and IgA/IgM responses to TRYCATs. We included 40 healthy controls and 80 participants with schizophrenia...
April 2018: Neurotoxicity Research
Caiyun Deng, Chang Xu, Xiaomin Zhang, J U Yao, Yingxin Zhang, B O Yu, Robert J Lee, Chengjun Jiang
BACKGROUND/AIM: Polymeric micelles are promising vehicles for paclitaxel delivery. Further improvement in the stability of the micelle formulation is desirable. MATERIALS AND METHODS: Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactide)-9-fluorenylmethoxycarbonyl-L-phenylalanine (mPEG-PDLLA-Phe(Fmoc)) was synthesized through a classical esterification reaction. Paclitaxel-loaded mPEG-PDLLA-Phe(Fmoc) micelles (PTX-PheMs) were prepared by the self-assembly method...
January 2018: Anticancer Research
Daniel J Brencic, Meredith Pinto, Adrienne Gill, Michael H Kinzer, Luis Hernandez, Omer G Pasi
Recent pandemics and rapidly spreading outbreaks of infectious diseases have illustrated the interconnectedness of the world and the importance of improving the international community's ability to effectively respond. The Centers for Disease Control and Prevention (CDC), building on a strong foundation of lessons learned through previous emergencies, international recognition, and human and technical expertise, has aspired to support nations around the world to strengthen their public health emergency management (PHEM) capacity...
December 2017: Emerging Infectious Diseases
Dale A Rose, Shivani Murthy, Jennifer Brooks, Jeffrey Bryant
The health impacts of recent global infectious disease outbreaks and other disasters have demonstrated the importance of strengthening public health systems to better protect communities from naturally occurring and human-caused threats. Public health emergency management (PHEM) is an emergent field of practice that draws on specific sets of knowledge, techniques, and organizing principles necessary for the effective management of complex health events. We highlight how the nascent field of PHEM has evolved in recent years...
September 2017: American Journal of Public Health
Ji Young Kim, Hemin Lee, Eun Jung Lee, Mikyoung Kim, Tae-Gyun Kim, Hyoung-Pyo Kim, Sang Ho Oh
BACKGROUND: Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. Yet in recent works, its role in melanogenesis together with cell protection functions against oxidative stress has been gaining interest. However, its effect on melanogenesis still has contradictory results from different studies. OBJECTIVE: The aims of our study were to investigate the effect of Keap1 silencing in melanocyte on melanogenesis and its associated mechanism. METHODS: Primary human epidermal melanocytes and melan-a cell line were used for this experiment...
October 2017: Journal of Dermatological Science
V A Kuttappan, C M Owens, C Coon, B M Hargis, M Vazquez-Añon
White striping (WS) and woody breast (WB) are 2 poultry meat quality defects that affect the acceptance of raw breast fillets as well as properties of cooked and further processed products. The present study was intended to evaluate the incidence of these conditions in broilers at different ages and to compare the properties of fillets with different degrees of WS and WB. For this study, 1,920 birds were processed, at 6 and 9 wk of age, in a standard commercial inline processing system. After chilling, carcasses were deboned and butterfly fillets were collected and weighed...
August 1, 2017: Poultry Science
A Vyas, V C Rodrigues, R Ayres, P R Myles, E J Hothersall, H Thomas
BACKGROUND: Public health faces the paradox of being increasingly emphasized by the key health and social care regulators and stakeholders, while remaining a largely under-represented discipline in the context of medical curricula. Enhancing medical student engagement in public health teaching is one way to address this concern. METHODS: We discuss four key solutions to the challenges faced by public health educators in medical schools, and present five case studies which demonstrate innovative approaches to engaging medical students in our discipline...
April 2017: Medical Teacher
Arshid Hussain Ganie, Altaf Ahmad, Peerzada Yasir Yousuf, Renu Pandey, Sayeed Ahmad, Ibrahim M Aref, Muhammad Iqbal
Sustainable development of cellular organisms depends on a precise coordination between the carbon and nitrogen metabolisms within the living system. Inorganic N is assimilated into amino acids which serve as an important N source for various regulatory metabolic pathways in plants. This study investigates the role of amino acids in C/N balance by examining changes in amino acid profile in the leaves and roots of low-N-tolerant (PHEM-2) and low-N-sensitive (HM-4) maize genotypes grown hydroponically under N-sufficient (4...
November 2017: Protoplasma
Gina C Gordon, Jeffrey C Cameron, Brian F Pfleger
Ribonucleases facilitate rapid turnover of RNA, providing cells with another mechanism to adjust transcript and protein levels in response to environmental conditions. While many examples have been documented, a comprehensive list of RNase targets is not available. To address this knowledge gap, we compared levels of RNA sequencing coverage of Escherichia coli and a corresponding RNase III mutant to expand the list of known RNase III targets. RNase III is a widespread endoribonuclease that binds and cleaves double-stranded RNA in many critical transcripts...
March 28, 2017: MBio
Jacqueline Montanaro, Daniela Gruber, Nikolaus Leisch
Many marine biology studies depend on field work on ships or remote sampling locations where sophisticated sample preservation techniques (e.g., high-pressure freezing) are often limited or unavailable. Our aim was to optimize the ultrastructural preservation of marine invertebrates, especially when working in the field. To achieve chemically-fixed material of the highest quality, we compared the resulting ultrastructure of gill tissue of the mussel Mytilus edulis when fixed with differently buffered EM fixatives for marine specimens (seawater, cacodylate and phosphate buffer) and a new fixative formulation with the non-toxic PHEM buffer (PIPES, HEPES, EGTA and MgCl2)...
2016: PeerJ
William H Seligman, Sameer Ganatra, David England, John J M Black
Prehospital emergency medicine (PHEM) is a recently recognised subspecialty of emergency medicine, and anaesthetics, intensive care and acute medicine, in the UK, and yet it receives little to no mention in many undergraduate medical curricula. However, there is growing interest in PHEM among medical students and junior doctors. Several programmes are in existence across the UK that serve to provide teaching and exposure of prehospital care to medical students and junior doctors. However, relatively few students are able to gain significant first-hand experience of treating patients in the prehospital phase...
February 2016: Emergency Medicine Journal: EMJ
Leila Bassir, Linda Dykes, Rob Perry
INTRODUCTION: We noticed that COPD patients travelling long distances to our rural ED arrived in a worse condition than those living nearby. We suspected this might be due to oxygen-driven nebulisers en route: high-flow oxygen during transfer is known to increase COPD mortality. METHODS: We conducted a retrospective chart review of ED patients who arrived by ambulance and were admitted with exacerbations of COPD December 2010-March 2011. ▸ 42/114 lacked ambulance records, leaving 72 cases for analysis...
May 2015: Emergency Medicine Journal: EMJ
Vinicio Carias, Jing Wang, Ryan Toomey
A series of terpolymers were synthesized comprising the following monomers: N-isopropylacrylamide (NIPAAm), a stimuli-responsive structural unit that swells and collapses in response to temperature; methacryloxybenzophenone (MaBP), a photo-cross-linking unit that is activated at a wavelength of 365 nm; and phenacyl methacrylate (PHEm), a photolabile protected carboxyl group that can be deprotected at a wavelength of 254 nm. It is shown that the terpolymers can be photo-cross-linked at long UV wavelength light (λ = 365 nm) to establish surface-attached, cross-linked coatings and subsequently photochemically cleaved at short UV wavelength light (λ = 254 nm), which is found to be consistent with first-order kinetics...
April 15, 2014: Langmuir: the ACS Journal of Surfaces and Colloids
Tzipora Strauss, Naomi Rozenzweig, Nurit Rosenberg, Boris Shenkman, Tami Livnat, Iris Morag, Yariv Fruchtman, Uri Martinowitz, Gili Kenet
BACKGROUND: Pulmonary hemorrhage (PHEM) complicates the hospital course of 3-5% of preterm infants with respiratory distress syndrome (RDS), and bears a high mortality rate. Impaired thrombin generation and poor clot formation in premature neonates affect PHEM severity. OBJECTIVES: We evaluated the impact of surfactant upon in-vitro clot formation in order to assess the role of surfactant in the pathogenesis of PHEM. METHODS: Blood samples were obtained from healthy volunteers for measuring complete blood count, PT, PTT, and platelet function...
November 2013: Thrombosis Research
A Booth, A Steel, J Klein
Major trauma is a leading cause of death and disability in the UK, particularly in the young. Pre-hospital emergency medicine (PHEM) involves provision of immediate medical care to critically ill and injured patients, across all age ranges, often in environments that may be remote and are not only physically challenging but also limited in terms of time and resources. PHEM is now a GMC-recognised subspecialty of anaesthesia or emergency medicine and the first recognised training program in the UK commenced in August 2012...
January 2013: Anaesthesia
Dimitris Platis, Nikolaos E Labrou
Plant molecular pharming is a technology that uses plants as bioreactors to produce recombinant molecules of medical and veterinary importance. In the present study, we evaluated the ability of histamine (HIM), tryptamine (TRM), phenylamine (PHEM) and tyramine (TYRM) coupled to Sepharose CL-4B via a 1,4-butanediol diglycidyl ether spacer to bind and purify human monoclonal anti-HIV antibody 2F5 (mAb 2F5) from spiked maize seed and tobacco leaf extracts. Detailed studies were carried out to determine the factors that affect the chromatographic behaviour of mAb 2F5 and also maize seed and tobacco leaf proteins...
March 2008: Journal of Separation Science
Nobuko Koshiba, Joji Ando, Xian Chen, Toshiaki Hisada
Atherosclerosis localizes at a bend andor bifurcation of an artery, and low density lipoproteins (LDL) accumulate in the intima. Hemodynamic factors are known to affect this localization and LDL accumulation, but the details of the process remain unknown. It is thought that the LDL concentration will be affected by the filtration flow, and that the velocity of this flow will be affected by deformation of the arterial wall. Thus, a coupled model of a blood flow and a deformable arterial wall with filtration flow would be invaluable for simulation of the flow field and concentration field in sequence...
June 2007: Journal of Biomechanical Engineering
A T Barnett, W Segree, A Matthews
A Pre-hospital Emergency Medical Service (PHEMS) is a vital component of a country's health service because it provides early medical care to critically ill and injured persons in the field There is evidence to show that early care reduces mortality and morbidity and offers the patient the best chance of survival and improved quality of life. Caribbean territories have been developing their PHEMS as part of a programme of health sector reform. In a study of PHEMS in 12 Caribbean countries, the Pan American Health Organization reported that there were no clear guidelines with respect to the roles and responsibilities of the physician in PHEMS in the majority of countries...
January 2006: West Indian Medical Journal
Toshihiro Nagai, Hiroaki Yokomori, Kazunori Yoshimura, Kayo Fujimaki, Masahiko Nomura, Toshifumi Hibi, Masaya Oda
The presence of microfilaments in the vicinity of sinusoidal endothelial fenestrae (SEF) suggests that the cytoskeleton of liver sinusoidal endothelial cells (LSEC) plays an important role in the modulation of SEF. In this study, we investigated actin filaments around SEF in LSECs. Monolayers of LSEC culture were established by infusing a rat liver with collagenase for 30 min and then culturing in RMPI medium for 24 h. Cells were reacted with 0.1% Triton X for 5 s and 15% glycerinated PHEM buffer (60 mM PIPES, 25 mM HEPES, 10 mM EGTA, 2 mM MgCl, pH 6...
December 2004: Medical Electron Microscopy: Official Journal of the Clinical Electron Microscopy Society of Japan
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