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https://www.readbyqxmd.com/read/28646685/a-highly-adhesive-and-naturally-derived-sealant
#1
Alexander Assmann, Andrea Vegh, Mohammad Ghasemi-Rad, Sara Bagherifard, George Cheng, Ehsan Shirzaei Sani, Guillermo U Ruiz-Esparza, Iman Noshadi, Antonio D Lassaletta, Sidhu Gangadharan, Ali Tamayol, Ali Khademhosseini, Nasim Annabi
Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, biocompatible, and biodegradable sealant based on a modified and naturally derived biopolymer, gelatin methacryloyl (GelMA). We tuned the degree of gelatin modification, prepolymer concentration, photoinitiator concentration, and crosslinking conditions to optimize the physical properties and adhesion of the photocrosslinked GelMA sealants...
June 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28643920/analysis-of-polycaprolactone-scaffolds-fabricated-via-precision-extrusion-deposition-for-control-of-craniofacial-tissue-mineralization
#2
C W Fedore, L Y L Tse, H K Nam, K L Barton, N E Hatch
OBJECTIVES: Recurrence of cranial bone fusion following surgical resection in craniosynostosis patients commonly requires additional surgical procedures. Surgical implantation of engineered 3D scaffolds that control tissue mineralization could be utilized to diminish recurrence of fusion. This study investigated the ability of composite scaffolds to control tissue mineralization when cultured in vitro. SETTING AND SAMPLE POPULATION: Precision-engineered scaffolds with calvarial cells were cultured in vitro at the Department of Orthodontics and Pediatric Dentistry, University of Michigan...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643153/a-3e8-scfv-cys-ir800-conjugate-targeting-tag-72-in-an-orthotopic-colorectal-cancer-model
#3
Li Gong, Haiming Ding, Nicholas E Long, Brandon J Sullivan, Edward W Martin, Thomas J Magliery, Michael F Tweedle
PURPOSE: Optical surgical navigation (OSN) will be a potent tool to help surgeons more accurately and efficiently remove tumors. The purpose of this study was to evaluate a novel humanized 3E8 antibody (3E8 MAb) fragment site-specifically conjugated with IR800, 3E8.scFv.Cys-IR800, as a potential OSN agent to target colorectal adenocarcinoma. PROCEDURES: An engineered single-chain variable fragment of 3E8 MAb (targeted to TAG-72), appending a C-terminal cysteine residue (3E8...
June 22, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28621834/from-intricate-to-integrated-biofabrication-of-articulating-joints
#4
Wilhelmina Margaretha Groen, Paweena Diloksumpan, Paul René van Weeren, Riccardo Levato, Jos Malda
Articulating joints owe their function to the specialized architecture and the complex interplay between multiple tissues including cartilage, bone and synovium. Especially the cartilage component has limited self-healing capacity and damage often leads to the onset of osteoarthritis, eventually resulting in failure of the joint as an organ. Although in its infancy, biofabrication has emerged as a promising technology to reproduce the intricate organization of the joint, thus enabling the introduction of novel surgical treatments, regenerative therapies, and new sets of tools to enhance our understanding of joint physiology and pathology...
June 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28617405/-orthotopic-bone-implants-for-bone-regeneration
#5
A A Muraev, S Yu Ivanov, S G Ivashkevich, V N Gorshenev, A T Teleshev, A V Kibardin, K K Kobets, V K Dubrovin
Biotechnology industry is rapidly developing. The elaboration of new biomaterials for bone reconstruction is one of the most perspective directions in tissue engineering. There are millions of surgical operations associated with use of bone graft materials every year. In this article we tried to analyze and systematize data about advanced technologies and modern trends in the preparation of bio-composite bone graft materials. Special attention is given to 3D-prototyping that allows making bone implants with individual form...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28616751/roles-of-amino-acids-in-preventing-and-treating-intestinal-diseases-recent-studies-with-pig-models
#6
REVIEW
Yulan Liu, Xiuying Wang, Yongqing Hou, Yulong Yin, Yinsheng Qiu, Guoyao Wu, Chien-An Andy Hu
Animal models are needed to study and understand a human complex disease. Because of their similarities in anatomy, structure, physiology, and pathophysiology, the pig has proven its usefulness in studying human gastrointestinal diseases, such as inflammatory bowel disease, ischemia/reperfusion injury, diarrhea, and cancer. To understand the pathogenesis of these diseases, a number of experimental models generated in pigs are available, for example, through surgical manipulation, chemical induction, microbial infection, and genetic engineering...
June 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/28614127/a-hospital-is-not-just-a-factory-but-a-complex-adaptive-system-implications-for-perioperative-care
#7
Aman Mahajan, Salim D Islam, Michael J Schwartz, Maxime Cannesson
Many methods used to improve hospital and perioperative services productivity and quality of care have assumed that the hospital is essentially a factory, and therefore, that industrial engineering and manufacturing-derived redesign approaches such as Six Sigma and Lean can be applied to hospitals and perioperative services just as they have been applied in factories. However, a hospital is not merely a factory but also a complex adaptive system (CAS). The hospital CAS has many subsystems, with perioperative care being an important one for which concepts of factory redesign are frequently advocated...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28608799/in-vitro-and-in-vivo-studies-of-alar-nasal-cartilage-using-autologous-micro-grafts-the-use-of-the-rigenera-%C3%A2-protocol-in-the-treatment-of-an-osteochondral-lesion-of-the-nose
#8
Gabriele Ceccarelli, Pietro Gentile, Marco Marcarelli, Martina Balli, Flavio Lorenzo Ronzoni, Laura Benedetti, Maria Gabriella Cusella De Angelis
Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue. Regarding the nose, nasal valve collapse is associated with nasal blockage and persistent airway obstruction associated with a significant drop in the quality of life for patients. In addition to surgical techniques, several cell-based tissue-engineering strategies are studied to improve cartilage support in the nasal wall, that is, to ameliorate wall insufficiency. Nevertheless, there are no congruent data available on the benefit for patients during the follow-up time...
June 13, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28608618/bench-to-bedside-bridge-enhanced-anterior-cruciate-ligament-repair
#9
REVIEW
Gabriel S Perrone, Benedikt L Proffen, Ata M Kiapour, Jakob T Sieker, Braden C Fleming, Martha M Murray
Anterior cruciate ligament (ACL) injuries are one of the most well-known orthopaedic injuries and are treated with one of the most common orthopaedic procedures performed in the United States. This surgical procedure, ACL reconstruction, is successful at restoring the gross stability of the knee. However, the outcomes of ACL reconstruction can be limited by short and long term complications, including muscle weakness, graft rupture and premature osteoarthritis. Thus, new methods of treating this injury are being explored...
June 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28606777/the-clinical-outcomes-of-vaginoplasty-using-tissue-engineered-biomaterial-mesh-in-patients-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#10
Xiaoli Zhang, Zhongyu Liu, Yizhuo Yang, Yuanqing Yao, Ye Tao
OBJECTIVE: The aim of the study is to evaluate the clinical outcomes of vaginoplasty using tissue-engineered biomaterial mesh in the patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. PATIENTS AND METHODS: Patients with MRKH syndrome underwent the vaginoplasty using tissue-engineered biomaterial mesh between January 2006 and August 2014 in PLA general hospital. We analyzed the anatomic results and collected the standardized FSFI (Female Sexual Function Index) questionnaire from each patient...
June 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28604885/developing-a-tissue-glue-by-engineering-the-adhesive-and-hemostatic-properties-of-metal-oxide-nanoparticles
#11
Martin T Matter, Fabian Starsich, Marco Galli, Markus Hilber, Andrea A Schlegel, Sergio Bertazzo, Sotiris E Pratsinis, Inge K Herrmann
Despite decades of research, wound complications remain a major cause of postoperative mortality, especially in the face of multiple comorbidities. Addressing the issue of anastomotic leakages and impaired wound healing from a new angle is of great interest with the prospect of having direct impact on patient outcome. Recently, aqueous suspensions of silica and iron oxide nanoparticles have been employed to connect biological tissue by serving as an adhesive layer eventually leading to macroscopic gluing of tissue...
June 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28594312/warning-about-the-use-of-critical-size-defects-for-the-translational-study-of-bone-repair-analysis-of-a-sheep-tibial-model
#12
Johan Lammens, Marina Maréchal, Liesbet Geris, Joshua Vanderaa, Hadewych Van Hauwermeiren, Frank P Luyten, Hendrik Delport
The repair of large long bone defects requires complex surgical procedures as the bone loss cannot simply be replaced by autologous grafts due to an insufficient bone stock of the human body. Tissue engineering strategies and the use of Advanced Therapy Medicinal Products (ATMPs) for these reconstructions remain a considerable challenge, in particular since robust outcomes in well-defined large animal models are lacking. To be suitable as a model for treatment of human sized bone defects we developed a large animal model in both skeletally immature and mature sheep and made close observations on the spontaneous healing of defects...
June 8, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28589561/computer-assisted-orthopaedic-surgery
#13
REVIEW
David Hernandez, Roja Garimella, Adam E M Eltorai, Alan H Daniels
Nowadays, operating rooms can be inefficient and overcrowded. Patient data and images are at times not well integrated and displayed in a timely fashion. This lack of coordination may cause further reductions in efficiency, jeopardize patient safety, and increase costs. Fortunately, technology has much to offer the surgical disciplines and the ongoing and recent operating room innovations have advanced preoperative planning and surgical procedures by providing visual, navigational, and mechanical computerized assistance...
June 7, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28589401/tissue-preservation-techniques-at-the-time-of-urethroplasty-for-urethral-stricture-disease
#14
REVIEW
Robert Caleb Kovell, Alexander J Skokan
Reconstructive surgery for urethral stricture disease seeks to re-establish long-lasting urethral patency while minimizing associated adverse effects. In recent years, genitourinary reconstructive surgeons have developed and refined a number of techniques that seek to decrease the impact of urethroplasty on local tissues including blood supply and innervation. This review presents an outline of recent advances in urethral reconstructive techniques that seek to minimize surgical impact, including tissue preservation, tissue engineering, and minimally invasive approaches and reviews the current state of the literature related to these techniques...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28589037/review-of-small-gauge-vitrectomy-progress-and-innovations
#15
REVIEW
Shaheeda Mohamed, Carl Claes, Chi Wai Tsang
Purpose. To summarise the surgical advances and evolution of small gauge vitrectomy and discuss its principles and application in modern vitreoretinal surgery. The advent of microincisional vitrectomy systems (MIVS) has created a paradigm shift away from twenty-gauge vitrectomy systems, which have been the gold standard in the surgical management of vitreoretinal diseases for over thirty years. Advances in biomedical engineering and surgical techniques have overcome the technical hurdles of shifting to smaller gauge instrumentation and sutureless surgery, improving surgical capabilities and expanding the indications for MIVS...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28586321/treatment-of-ischemia-reperfusion-injury-of-the-skin-flap-using-human-umbilical-cord-mesenchymal-stem-cells-huc-mscs-transfected-with-f-5-gene
#16
Xiangfeng Leng, Yongle Fan, Yating Wang, Jian Sun, Xia Cai, Chunnan Hu, Xiaoying Ding, Xiaoying Hu, Zhengyu Chen
BACKGROUND Recent studies have shown that skin flap transplantation technique plays an important role in surgical procedures. However, there are many problems in the process of skin flap transplantation surgeries, especially ischemia-reperfusion injury, which directly affects the survival rate of the skin flap and patient prognosis after surgeries. MATERIAL AND METHODS In this study, we used a new method of the "stem cells-gene" combination therapy. The "F-5" gene fragment of heat shock protein 90-α (Hsp90-α) was transfected into human umbilical cord mesenchymal stem cells (hUC-MSCs) by genetic engineering technique...
June 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28585216/does-bariatric-surgery-improve-obesity-associated-comorbid-conditions
#17
Atilla Engin
Obesity is a constantly growing health problem which reduces quality of life and life expectancy. Bariatric surgery for obesity is taken into account when all other conservative treatment modalities have failed. Comparison of the multidisciplinary programs with bariatric surgery regarding to weight loss showed that substantial and durable weight reduction have been achieved only with bariatric surgical treatments. However, the benefits of weight loss following bariatric procedures are still debated regarding the pro-inflammatory and metabolic profile of obesity...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28582392/mechanical-characterization-of-human-brain-tumors-from-patients-and-comparison-to-potential-surgical-phantoms
#18
Daniel C Stewart, Andrés Rubiano, Kyle Dyson, Chelsey S Simmons
While mechanical properties of the brain have been investigated thoroughly, the mechanical properties of human brain tumors rarely have been directly quantified due to the complexities of acquiring human tissue. Quantifying the mechanical properties of brain tumors is a necessary prerequisite, though, to identify appropriate materials for surgical tool testing and to define target parameters for cell biology and tissue engineering applications. Since characterization methods vary widely for soft biological and synthetic materials, here, we have developed a characterization method compatible with abnormally shaped human brain tumors, mouse tumors, animal tissue and common hydrogels, which enables direct comparison among samples...
2017: PloS One
https://www.readbyqxmd.com/read/28579539/preparation-of-acellular-scaffold-for-corneal-tissue-engineering-by-supercritical-carbon-dioxide-extraction-technology
#19
Yi-Hsun Huang, Fan-Wei Tseng, Wen-Hsin Chang, I-Chen Peng, Dar-Jen Hsieh, Shu-Wei Wu, Ming-Long Yeh
In this study, we developed a novel method using supercritical carbon dioxide (SCCO2) to prepare acellular porcine cornea (APC). Under gentle extraction conditions using SCCO2 technology, hematoxylin and eosin staining showed that cells were completely lysed, and cell debris, including nuclei, was efficiently removed from the porcine cornea. The SCCO2-treated corneas exhibited intact stromal structures and appropriate mechanical properties. Moreover, no immunological reactions and neovascularization were observed after lamellar keratoplasty in rabbits...
June 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28567563/ros-igtl-bridge-an-open-network-interface-for-image-guided-therapy-using-the-ros-environment
#20
Tobias Frank, Axel Krieger, Simon Leonard, Niravkumar A Patel, Junichi Tokuda
PURPOSE: With the growing interest in advanced image-guidance for surgical robot systems, rapid integration and testing of robotic devices and medical image computing software are becoming essential in the research and development. Maximizing the use of existing engineering resources built on widely accepted platforms in different fields, such as robot operating system (ROS) in robotics and 3D Slicer in medical image computing could simplify these tasks. We propose a new open network bridge interface integrated in ROS to ensure seamless cross-platform data sharing...
May 31, 2017: International Journal of Computer Assisted Radiology and Surgery
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