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https://www.readbyqxmd.com/read/29775757/molecular-characterization-of-physis-tissue-by-rna-sequencing
#1
Christopher R Paradise, Catalina Galeano-Garces, Daniela Galeano-Garces, Amel Dudakovic, Todd A Milbrandt, Daniel B F Saris, Aaron J Krych, Marcel Karperien, Gabriel B Ferguson, Denis Evseenko, Scott M Riester, Andre J van Wijnen, A Noelle Larson
The physis is a well-established and anatomically distinct cartilaginous structure that is crucial for normal long-bone development and growth. Abnormalities in physis function are linked to growth plate disorders and other pediatric musculoskeletal diseases. Understanding the molecular pathways operative in the physis may permit development of regenerative therapies to complement surgically-based procedures that are the current standard of care for growth plate disorders. Here, we performed next generation RNA sequencing on mRNA isolated from human physis and other skeletal tissues (e...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29773449/primary-bone-tumors-and-tumor-like-lesions-of-the-ulna
#2
Osman Emre Aycan, Sami Sökücü, Devrim Özer, Engin Çetinkaya, Yavuz Arıkan, Yavuz Selim Kabukçuoğlu
OBJECTIVE: The aim of this study was to discuss the diagnosis and surgical management and their results according to stage of primary bone tumors at ulna and to share our experience on this exceptional location for bone tumors. METHODS: We have retrospectively reviewed our clinics database and identified 23 cases (14 males and 9 females, mean age was 28.9 (range 4-77)) with primary bone tumors and tumor like lesion involvement of ulna. The patients were evaluated according to complaints, type and grade of tumor, treatment, recurrence and functional status...
May 14, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29772691/periodontal-tissues-maxillary-jaw-bone-and-tooth-regeneration-approaches-from-animal-models-analyses-to-clinical-applications
#3
REVIEW
Fareeha Batool, Marion Strub, Catherine Petit, Isaac Maximiliano Bugueno, Fabien Bornert, François Clauss, Olivier Huck, Sabine Kuchler-Bopp, Nadia Benkirane-Jessel
This review encompasses different pre-clinical bioengineering approaches for periodontal tissues, maxillary jaw bone, and the entire tooth. Moreover, it sheds light on their potential clinical therapeutic applications in the field of regenerative medicine. Herein, the electrospinning method for the synthesis of polycaprolactone (PCL) membranes, that are capable of mimicking the extracellular matrix (ECM), has been described. Furthermore, their functionalization with cyclosporine A (CsA), bone morphogenetic protein-2 (BMP-2), or anti-inflammatory drugs' nanoreservoirs has been demonstrated to induce a localized and targeted action of these molecules after implantation in the maxillary jaw bone...
May 16, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29770300/tissue-engineered-vascular-grafts-for-pediatric-cardiac-surgery
#4
REVIEW
Toshihiro Shoji, Toshiharu Shinoka
New technologies and science have contributed to improved surgical outcomes in patients with congenital cardiovascular diseases. However, current materials display shortcomings, such as risk of infection and lack of growth capacity when applied to the pediatric patient population. Tissue engineering has the potential to address these limitations as the ideal tissue engineered vascular graft (TEVG) would be durable, biocompatible, nonthrombogenic, and ultimately remodel into native tissue. The traditional TEVG paradigm consists of a scaffold, cell source, and the integration of the scaffold and cells via seeding...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29769541/modchimera-a-novel-murine-closed-head-model-of-moderate-traumatic-brain-injury
#5
A D Sauerbeck, C Fanizzi, J H Kim, M Gangolli, P V Bayly, C L Wellington, D L Brody, T T Kummer
Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation. We report a tunable, monitored model of murine non-surgical, diffuse closed-head injury-modCHIMERA-characterized by impact as well as linear and rotational acceleration. modCHIMERA is based on the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) platform. We tested this model at 2 energy levels: 1.7 and 2.1 Joules-substantially higher than previously reported for this system...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769537/a-co-culture-system-of-rat-synovial-stem-cells-and-meniscus-cells-promotes-cell-proliferation-and-differentiation-as-compared-to-mono-culture
#6
Xing Xie, Jingxian Zhu, Xiaoqing Hu, Linghui Dai, Xin Fu, Jiying Zhang, Xiaoning Duan, Yingfang Ao
A meniscus tear often happens during active sports. It needs to be repaired or replaced surgically to avoid further damage to the articular cartilage. To address the shortage of autologous meniscal cells, we designed a co-culture system of synovial stem cells (SMSCs) and meniscal cells (MCs) to produce a large cell number and to maintain characteristics of MCs. Different ratios of SMSCs and MCs at 3:1, 1:1, and 1:3 were tested. Mono-culture of SMSCs or MCs served as control groups. Proliferation and differentiation abilities were compared...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765427/adipose-derived-mesenchymal-stem-cells-in-the-use-of-cartilage-tissue-engineering-the-need-for-a-rapid-isolation-procedure
#7
REVIEW
Sam L Francis, Serena Duchi, Carmine Onofrillo, Claudia Di Bella, Peter F M Choong
Mesenchymal stem cells (MSCs) have shown much promise with respect to their use in cartilage tissue engineering. MSCs can be obtained from many different tissue sources. Among these, adipose tissue can provide an abundant source of adipose-derived mesenchymal stem cells (ADMSCs). The infrapatellar fat pad (IFP) is a promising source of ADMSCs with respect to producing a cartilage lineage. Cell isolation protocols to date are time-consuming and follow conservative approaches that rely on a long incubation period of 24-48 hours...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29763517/novel-engineered-tendon-fibrocartilage-bone-composite-with-cyclic-tension-for-rotator-cuff-repair
#8
Qian Liu, Taku Hatta, Jun Qi, Haoyu Liu, Andrew R Thoreson, Peter C Amadio, Steven L Moran, Scott P Steinmann, Anne Gingery, Chunfeng Zhao
Surgical repair of rotator cuff tears presents a significant clinical challenge with high failure rates and inferior functional outcomes. Graft augmentation improves repair outcomes, however currently available grafting materials have limitations. While cell-seeded decellularized tendon slices may facilitate cell infiltration, promote tendon incorporation and preserve original mechanical strength, the unique fibrocartilage zone is yet to be successfully reestablished. In this study, we investigated the biological and mechanical properties of an engineered tendon-fibrocartilage-bone composite (TFBC) with cyclic tension (3% strain, 0...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29763386/trends-in-polymeric-electrospun-fibers-and-their-use-as-oral-biomaterials
#9
Agnes B Meireles, Daniella K Corrêa, João Vw da Silveira, Ana Lg Millás, Edison Bittencourt, Gustavo Ea de Brito-Melo, Libardo A González-Torres
Electrospinning is one of the techniques to produce structured polymeric fibers in the micro or nano scale and to generate novel materials for biomedical proposes. Electrospinning versatility provides fibers that could support different surgical and rehabilitation treatments. However, its diversity in equipment assembly, polymeric materials, and functional molecules to be incorporated in fibers result in profusion of recent biomaterials that are not fully explored, even though the recognized relevance of the technique...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29760099/hydrogel-delivery-of-lysostaphin-eliminates-orthopedic-implant-infection-by-staphylococcus-aureus-and-supports-fracture-healing
#10
Christopher T Johnson, James A Wroe, Rachit Agarwal, Karen E Martin, Robert E Guldberg, Rodney M Donlan, Lars F Westblade, Andrés J García
Orthopedic implant infections are a significant clinical problem, with current therapies limited to surgical debridement and systemic antibiotic regimens. Lysostaphin is a bacteriolytic enzyme with high antistaphylococcal activity. We engineered a lysostaphin-delivering injectable PEG hydrogel to treat Staphylococcus aureus infections in bone fractures. The injectable hydrogel formulation adheres to exposed tissue and fracture surfaces, ensuring efficient, local delivery of lysostaphin. Lysostaphin encapsulation within this synthetic hydrogel maintained enzyme stability and activity...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29756600/the-development-of-neural-stimulators-a-review-of-preclinical-safety-and-efficacy-studies
#11
Robert K Shepherd, Joel Villalobos, Owen Burns, David Nayagam
OBJECTIVE: Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technology. APPROACH: The present review examines basic design principles associated with the development of a safe neural stimulator and describes the suite of preclinical safety studies that need to be considered when taking a device to clinical trial...
May 14, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#12
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29756099/can-volumetric-measurement-be-used-in-the-selection-of-treatment-for-inguinoscrotal-hernias
#13
Metin Ertem, Hakan Gök, Volkan Özben, Engin Hatipoğlu, Erdem Yıldız
Objective: Inguinoscrotal hernias are often qualified subjectively as big, giant, scrotal, etc. In order to classify this type of hernia, objective criteria are needed. For this purpose, we aimed to introduce a scrotal volume measurement-based classification system and propose a corresponding surgical plan (open or laparoscopic surgery, anterior or posterior repair) based on volumetric data. Material and Methods: Between October 2012 and October 2013, 30 consecutive male patients with a mean age of 59...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29753132/prevention-of-eskape-pathogen-biofilm-formation-by-antimicrobial-peptides-wlbu2-and-ll37
#14
Qiao Lin, Berthony Deslouches, Ronald C Montelaro, Y Peter Di
OBJECTIVES: Bacterial biofilm-dependent infections (e.g., cystic fibrosis, surgical sites, and medical implants) are associated with enhanced drug-resistance and thus difficult to eradicate. The goal of this study was to systematically compare three distinct classes of antimicrobial peptides (AMPs) that include the clinically used antibiotic colistin, the natural AMP LL37, the engineered cationic-AMP WLBU2, and four commonly used antibiotics with different bactericidal mechanisms (tobramycin, ciprofloxacin, ceftazidime and vancomycin) for biofilm prevention properties...
May 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29752426/protein-engineering-on-human-recombinant-follistatin-enhancing-pharmacokinetic-characteristics-for-therapeutic-application
#15
Chuan Shen, Andrea Iskenderian, Dianna Lundberg, Tao He, Kathleen Palmieri, Robert Crooker, Qingwei Deng, Matthew Traylor, Sheng Gu, Haojing Rong, David Ehmann, Brian Pescatore, Bettina Strack-Logue, Alla Romashko, George Baviello, John Gill, Bohong Zhang, Muthuraman Meiyappan, Clark Pan, Angela W Norton
Follistatin (FS) is an important regulatory protein, a natural antagonist for transforming growth factor beta family members activin and myostatin. The diverse biological roles of the activin and myostatin signaling pathways make FS a promising therapeutic target for treating human diseases exhibiting inflammation, fibrosis and muscle disorders, such as Duchenne muscular dystrophy. However, rapid heparin-mediated hepatic clearance of FS limits its therapeutic potential. We targeted the heparin binding loop of FS for site-directed mutagenesis to improve clearance parameters...
May 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29746554/effects-of-collagen-matrix-and-bioreactor-cultivation-on-cartilage-regeneration-of-a-full-thickness-critical-size-knee-joint-cartilage-defects-with-subchondral-bone-damage-in-a-rabbit-model
#16
Kuo-Hwa Wang, Richard Wan, Li-Hsuan Chiu, Yu-Hui Tsai, Chia-Lang Fang, John F Bowley, Kuan-Chou Chen, Hsin-Nung Shih, Wen-Fu Thomas Lai
Cartilage has limited self-repair ability. The purpose of this study was to investigate the effects of different species of collagen-engineered neocartilage for the treatment of critical-size defects in the articular joint in a rabbit model. Type II and I collagen obtained from rabbits and rats was mixed to form a scaffold. The type II/I collagen scaffold was then mixed with rabbit chondrocytes to biofabricate neocartilage constructs using a rotating cell culture system [three-dimensional (3D)-bioreactor]. The rabbit chondrocytes were mixed with rabbit collagen scaffold and rat collagen scaffold to form neoRBT (neo-rabbit cartilage) and neoRAT (neo-rat cartilage) constructs, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29746144/effects-of-allogenic-dermal-fibroblasts-on-rotator-cuff-healing-in-a-rabbit-model-of-chronic-tear
#17
Jieun Kwon, Yun Hee Kim, Sung-Min Rhee, Tae In Kim, Jimin Lee, Saewha Jeon, Joo Han Oh
BACKGROUND: The failure of rotator cuffs to heal after repair is an unresolved surgical issue. There have been substantial efforts, including the use of biological supplements, to enhance tendon healing. Dermal fibroblasts are a good candidate for tendon tissue engineering because they are similar to the tenocytes used for collagen synthesis. In addition, they are easily accessible because autologous dermal fibroblasts can be obtained from individual skin without major skin defects and allogenic dermal fibroblasts (ADFs) have already been commercialized in the field of skin engineering...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29745340/problems-in-stem-cell-therapy-for-cardiac-repair-and-tissue-engineering-approaches-based-on-graphene-and-its-derivatives
#18
Ayca Aslan, Adil Allahverdiyev, Melahat Bagirova, Emrah Abamor
BACKGROUND: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair...
May 9, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29744436/lipid-polymer-hybrid-nanoparticles-development-statistical-optimization-of-norfloxacin-for-topical-drug-delivery-system
#19
Vivek Dave, Renu Bala Yadav, Kriti Kushwaha, Sachdev Yadav, Swapnil Sharma, Udita Agrawal
Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceutical preparations such as controlled release formulations, parenteral preparations, surgical treatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticles for topical and site targeting delivery of Norfloxacin by emulsification solvent evaporation method (ESE). The design of experiment (DOE) was done by using software to optimize the result, and then a surface plot was generated to compare with the practical results...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29743810/auricular-cartilage-regeneration-with-adipose-derived-stem-cells-in-rabbits
#20
Se-Joon Oh, Hee-Young Park, Kyung-Un Choi, Sung-Won Choi, Sung-Dong Kim, Soo-Keun Kong, Kyu-Sup Cho
Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investigate whether ASCs can promote the auricular cartilage regeneration in the rabbit. In order to assess their differentiation ability, ASCs were injected into the midportion of a surgically created auricular cartilage defect in the rabbit...
2018: Mediators of Inflammation
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