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https://www.readbyqxmd.com/read/29333729/immunoengineering-with-biomaterials-for-enhanced-cancer-immunotherapy
#1
REVIEW
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#2
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29329407/transplant-buccaneers-p-k-sen-and-india-s-first-heart-transplant-february-1968
#3
David S Jones, Kavita Sivaramakrishnan
On 17 February 1968, Bombay surgeon Prafulla Kumar Sen transplanted a human heart, becoming the fourth surgeon in the world to attempt the feat. Even though the patient survived just three hours, the feat won Sen worldwide acclaim. The ability of Sen's team to join the ranks of the world's surgical pioneers raises interesting questions. How was Sen able to transplant so quickly? He had to train a team of collaborators, import or reverse engineer technologies and techniques that had been developed largely in the United States, and begin conversations with Indian political authorities about the contested concept of brain death...
January 10, 2018: Journal of the History of Medicine and Allied Sciences
https://www.readbyqxmd.com/read/29327564/neo-pulmonary-valve-fabrication-using-tissue-engineered-pericardium-a-new-surgical-technique
#4
Jaroslav Benedik, Sharaf-Eldin Shehada, Fanar Mourad, Yacine Elhmidi, Juri Lubarski, Konstantinos Tsagakis, Heinz Jakob
No abstract text is available yet for this article.
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29327490/fetal-subcutaneous-cells-have-potential-for-autologous-tissue-engineering
#5
Åsa Ekblad, Magnus Westgren, Magdalena Fossum, Cecilia Götherström
BACKGROUND: Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells (fSC) as cellular source for tissue engineering. METHODS: Fetal subcutaneous biopsies were collected from elective terminations at gestational week 20-21. Cells were isolated, expanded and characterized in vitro...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29321630/engineered-mesenchymal-stem-cell-sheets-patches-prevents-postoperative-pancreatic-leakage-in-a-rat-model
#6
Seong-Ryong Kim, Hye-Jin Yi, Yu Na Lee, Ji Yoon Park, Robert M Hoffman, Teruo Okano, In Kyong Shim, Song Cheol Kim
Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of the preventative ability for pancreatic leakage in a rat model. Both rat adipose-derived stem cell (rADSC) and bone marrow-derived stem cell (rBMSC) sheets were transplanted. Those rADSC and rBMSC sheets are created without enzymes and thus maintained their cell-cell junctions and adhesion proteins with intact fibronectin on the basal side, as well as characteristics of MSCs...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313454/a-multicenter-experience-with-a-new-fenestrated-branched-device-for-endovascular-repair-of-thoracoabdominal-aortic-aneurysms
#7
Marwan Youssef, Sebastien Deglise, Piotr Szopinski, Schäfer Jost-Philipp, Amer Jomha, Christian F Vahl, Ahmed Koshty
PURPOSE: To investigate the outcomes of patients who were treated for thoracoabdominal aortic aneurysms (TAAAs) using custom-made fenestrated-branched stent-grafts. METHODS: A consecutive series of 108 patients (mean age 73.5 years; 73 men) with TAAA were treated with E-xtra Design Engineering customized fenestrated-branched stent-grafts between November 2011 and January 2017. Data on baseline characteristics, procedures, and clinical follow-up were collected from 6 regional European surgical centers for retrospective analysis of endoleaks, reinterventions, and target vessel patency...
January 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29303407/vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#8
Zhi Wang, Jiuzuo Huang, Ang Zeng, Ming Wu, Xiaojun Wang
Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29300390/a-surgical-orthotopic-organoid-transplantation-approach-in-mice-to-visualize-and-study-colorectal-cancer-progression
#9
Arianna Fumagalli, Saskia J E Suijkerbuijk, Harry Begthel, Evelyne Beerling, Koen C Oost, Hugo J Snippert, Jacco van Rheenen, Jarno Drost
Most currently available colorectal cancer (CRC) mouse models are not suitable for studying progression toward the metastatic stage. Recently, establishment of tumor organoid lines, either from murine CRC models or patients, and the possibility of engineering them with genome-editing technologies, have provided a large collection of tumor material faithfully recapitulating phenotypic and genetic heterogeneity of native tumors. To study tumor progression in the natural in vivo environment, we developed an orthotopic approach based on transplantation of CRC organoids into the cecal epithelium...
February 2018: Nature Protocols
https://www.readbyqxmd.com/read/29299496/effects-of-human-adipose-derived-stem-cells-and-platelet-rich-plasma-on-healing-response-of-canine-alveolar-surgical-bone-defects
#10
Reihaneh Shafieian, Maryam Moghaddam Matin, Amin Rahpeyma, Alireza Fazel, Hamideh Salari Sedigh, Ariane Sadr Nabavi, Halimeh Hassanzadeh, Alireza Ebrahimzadeh-Bideskan
Background: Due to the known disadvantages of autologous bone grafting, tissue engineering approaches have become an attractive method for ridge augmentation in dentistry. To the best of our knowledge, this is the first study conducted to evaluate the potential therapeutic capacity of PRP-assisted hADSCs seeded on HA/TCP granules on regenerative healing response of canine alveolar surgical bone defects. This could offer a great advantage to alternative approaches of bone tissue healing-induced therapies at clinically chair-side procedures...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29298526/comparison-of-radiofrequency-and-transoral-robotic-surgery-in-obstructive-sleep-apnea-syndrome-treatment
#11
Engin Aynacı, Murat Karaman, Burak Kerşin, Mahmut Ozan Fındık
INTRODUCTION: Radiofrequency tissue ablation (RFTA) and transoral robotic surgery (TORS) are the methods used in OSAS surgery. We also aimed to compare the advantages and disadvantages of RF and TORS as treatment methods applied in OSAS patients in terms of many parameters, especially apnea hypopnea index (AHI). MATERIALS AND METHODS: Patients were classified by performing a detailed examination and evaluation before surgery. 20 patients treated with anterior palatoplasty and uvulectomy -/+ tonsillectomy + RFTA (17 males, 3 females) and 20 patients treated with anterior palatoplasty and uvulectomy -/+  tonsillectomy + TORS (16 males, 4 females) were included in the study...
January 3, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29290537/assessment-of-variability-in-turkish-spine-surgeons-trauma-practices
#12
Engin Çetin, Alpaslan Şenköylü, Emre Acaroğlu
OBJECTIVES: The aim of this study was to analyse the variability among Turkish spinal surgeons in the management of thoracolumbar fractures by carrying out a web survey. METHODS: An invitation text and web-link of the survey were sent to the members of the Turkish Spine Society mail group. A fictitious spine trauma vignette, a 23 year-old male with a L1 burst fracture, was presented and 25 questions were asked to participants. Variability of answers in a given question was assessed with the Index of Qualitative Variation (IQV)...
December 28, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29286120/influence-of-static-magnetic-fields-on-human-myoblast-mesenchymal-stem-cell-co%C3%A2-cultures
#13
Cornelia Emika Mueller, Richard Birk, Benedikt Kramer, Angela Wenzel, J Ulrich Sommer, Karl Hörmann, Jens Stern-Straeter, Christian Weilbach
The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defect closure. Despite intensive research efforts, the goal of stable induction of myogenic differentiation in expanded human stem cells by using clinically feasible stimuli, has not yet been reached to a sufficient extent...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29280323/biomimetic-tissue-engineered-bone-substitutes-for-maxillofacial-and-craniofacial-repair-the-potential-of-cell-sheet-technologies
#14
REVIEW
Fabien Kawecki, William P Clafshenkel, Michel Fortin, François A Auger, Julie Fradette
Maxillofacial defects are complex lesions stemming from various etiologies: accidental, congenital, pathological, or surgical. A bone graft may be required when the normal regenerative capacity of the bone is exceeded or insufficient. Surgeons have many options available for bone grafting including the "gold standard" autologous bone graft. However, this approach is not without drawbacks such as the morbidity associated with harvesting bone from a donor site, pain, infection, or a poor quantity and quality of bone in some patient populations...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29278578/situation-dependent-medical-device-risk-estimation-design-and-evaluation-of-an-equipment-management-center-for-vendor-independent-integrated-operating-rooms
#15
Marianne Maktabi, Thomas Neumuth
OBJECTIVES: The complexity of surgical interventions and the number of technologies involved are constantly rising. Hospital staff has to learn how to handle new medical devices efficiently. However, if medical device-related incidents occur, the patient treatment is delayed. Patient safety could therefore be supported by an optimized assistance system that helps improve the management of technical equipment by nonmedical hospital staff. METHODS: We developed a system for the optimal monitoring of networked medical device activity and maintenance requirements, which works in conjunction with a vendor-independent integrated operating room and an accurate surgical intervention Time And Resource Management System...
December 22, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29277756/pacifastin-derived-peptides-target-tumors-for-use-in-in-vivo-imaging
#16
Theo L Sottero, Emily J Girard, Carrie Myers, Gene Hopping, Andrew J Mhyre, James M Olson
BACKGROUND/AIM: Developments in imaging have improved cancer diagnosis, but identification of malignant cells during surgical resection remains a challenge. The aim of this study was to investigate the pacifastin family of peptides for novel activity targeting tumor cells and the delivery of either imaging or therapeutic agents. MATERIALS AND METHODS: Variants of pacifastin family peptides were generated, chemically modified and tested in human tumor xenografts...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277753/managing-focal-nodular-hyperplasia-of-the-liver-surgery-or-minimally-invasive-approaches-a-review-of-the-preferable-treatment-options
#17
REVIEW
Edoardo Virgilio, Marco Cavallini
BACKGROUND/AIM: Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver. As of 2017, many clinical, radiological and surgical features have been largely documented. On the other hand, little is still known about the correlation of FNH with hepatocellular carcinoma, nor the preferable modality of treatment. Our aim was to elucidate the latter topic. MATERIALS AND METHODS: We investigated the pertinent literature available as of 2017 through four popular search engines (PubMed, Science Direct, Scopus and Google Scholar)...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29276625/epicardial-delivery-of-autologous-atrial-appendage-micrografts-during-coronary-artery-bypass-surgery-safety-and-feasibility-study
#18
Annu Nummi, Tuomo Nieminen, Tommi Pätilä, Milla Lampinen, Miia L Lehtinen, Sari Kivistö, Miia Holmström, Erika Wilkman, Kari Teittinen, Mika Laine, Juha Sinisalo, Markku Kupari, Esko Kankuri, Tatu Juvonen, Antti Vento, Raili Suojaranta, Ari Harjula
Background: The atrial appendages are a tissue reservoir for cardiac stem cells. During on-pump coronary artery bypass graft (CABG) surgery, part of the right atrial appendage can be excised upon insertion of the right atrial cannula of the heart-lung machine. In the operating room, the removed tissue can be easily cut into micrografts for transplantation. This trial aims to assess the safety and feasibility of epicardial transplantation of atrial appendage micrografts in patients undergoing CABG surgery...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29276039/diagnosis-and-treatment-of-osteochondritis-dissecans-of-the-humeral-capitellum
#19
Masahiro Maruyama, Masatoshi Takahara, Hiroshi Satake
Osteochondritis dissecans (OCD) of the humeral capitellum is a critical elbow injury in adolescent overhead throwing athletes. However, its etiology remains unknown. Medical examinations using ultrasonography found that the prevalence of capitellar OCD among adolescent baseball players was approximately from 1% to 3%. A plain anteroposterior radiograph with the elbow in 45° of flexion is essential for the diagnosis of an OCD lesion. The stability of OCD lesions is evaluated on plain radiographs, computed tomography, and magnetic resonance imaging (MRI)...
December 21, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29273750/elimination-of-antibiotic-resistant-surgical-implant-biofilms-using-an-engineered-cationic-amphipathic-peptide-wlbu2
#20
Jonathan B Mandell, Berthony Deslouches, Ronald C Montelaro, Robert M Q Shanks, Yohei Doi, Kenneth L Urish
Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state. WLBU2 is an engineered cationic amphipathic peptide designed to maximize antimicrobial activity with minimal mammalian cell toxicity. The objective of this study was to test the ability of WLBU2 to remove Staphylococcus aureus surgical implant biofilms. WLBU2 effectively treated S...
December 22, 2017: Scientific Reports
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