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https://www.readbyqxmd.com/read/29745284/regional-and-temporal-variations-in-comorbidity-among-us-dialysis-patients-a-longitudinal-study-of-medicare-claims-data
#1
Yi Mu, Andrew I Chin, Abhijit V Kshirsagar, Yi Zhang, Heejung Bang
Medicare claims data are commonly used to query comorbidities for case-mix adjustment in research of patients with end-stage renal disease (ESRD) in the United States. These adjustments may affect reimbursement and quality rating through comparative profiling and ranking of dialysis facilities. We studied regional and temporal variations in comorbidity from claims data in the United States Renal Data System. Patients with a previous 1-year Medicare history who initiated dialysis therapy between 2006 and 2009 were examined with a follow-up period until 2012...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29717956/smiles-turnout-candidates-and-the-winning-of-district-seats
#2
Masahiko Asano, Dennis P Patterson
Research has shown that a candidate's appearance affects the support he or she receives in elections. We extend this research in this article in three ways. First, we examine this relationship further in a non-Western context using 2015 local elections in Japan. Next, we show that this positive relationship is more complicated depending on the characteristics of the election under consideration. Specifically, we distinguished election contests by levels of turnout and found that despite a positive relationship between turnout and the extent to which smiling increases a candidate's support levels, the marginal increase in support declined as turnout increased and, in fact, became negative when some high-turnout threshold was crossed...
2018: Politics and the Life Sciences: the Journal of the Association for Politics and the Life Sciences
https://www.readbyqxmd.com/read/29670762/rolling-refresher-simulation-improves-performance-and-retention-of-paediatric-intensive-care-unit-nurse-code-cart-management
#3
Marcy N Singleton, Kimberly F Allen, Zhongze Li, Kevin McNerney, Urs H Naber, Matthew S Braga
Introduction: Paediatric Intensive Care Unit Nurses (PICU RNs) manage the code cart during paediatric emergencies at the Children's Hospital at Dartmouth-Hitchcock. These are low -frequency, high-stakes events. Methods: An uncontrolled intervention study with 6-month follow-up. A collaboration of physician and nursing experts developed a rolling-refresher training programme consisting of five simulated scenarios, including 22 code cart skills, to establish nursing code cart competency...
April 2018: BMJ simulation & technology enhanced learning
https://www.readbyqxmd.com/read/29662506/patterns-of-in-hospital-mortality-and-bleeding-complications-following-pci-for-very-elderly-patients-insights-from-the-dartmouth-dynamic-registry
#4
Shawn X Li, Hannah I Chaudry, Jiyong Lee, Theodore B Curran, Vishesh Kumar, Kendrew K Wong, Bruce W Andrus, James T DeVries
Background: Very elderly patients (age ≥ 85 years) are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention (PCI). However, the relationship between bleeding and mortality in the very elderly is unknown. Methods: Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29659714/computation-and-application-of-tissue-specific-gene-set-weights
#5
H Robert Frost
Motivation: Gene set testing, or pathway analysis, has become a critical tool for the analysis of highdimensional genomic data. Although the function and activity of many genes and higher-level processes is tissue-specific, gene set testing is typically performed in a tissue agnostic fashion, which impacts statistical power and the interpretation and replication of results. Results: To address this challenge, we have developed a bioinformatics approach to compute tissuespecific weights for individual gene sets using information on tissue-specific gene activity from the Human Protein Atlas (HPA)...
April 6, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29606286/referral-regions-for-time-sensitive-acute-care-conditions-in-the-united-states
#6
David J Wallace, Deepika Mohan, Derek C Angus, Julia R Driessen, Christopher M Seymour, Donald M Yealy, Mark M Roberts, Kristen S Kurland, Jeremy M Kahn
STUDY OBJECTIVE: Regional, coordinated care for time-sensitive and high-risk medical conditions is a priority in the United States. A necessary precursor to coordinated regional care is regions that are actionable from clinical and policy standpoints. The Dartmouth Atlas of Health Care, the major health care referral construct in the United States, uses regions that cross state and county boundaries, limiting fiscal or political ownership by key governmental stakeholders in positions to create incentive and regulate regional care coordination...
March 24, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29550466/a-spontaneous-metastatic-mathematical-model-in-mice-for-screening-anti-metastatic-agents
#7
Yao Li, Zhiqiang Yue, Hua Yu, Xiaojian Liu, Li Tao, Zhijie Zhu, Fangtian Fan, Cunsi Shen, Aiyun Wang, Wenxing Chen, Yin Lu
PURPOSE: A computational model based on clinical data from pancreatic cancer patients has been successfully created and used for predicting tumor sizes in primary and metastasis sites and survival time from kinetics of tumor cells, such as growth rate, metastasis rate and mutation rate, etc. Whether this computational model could be fitted or necessary modification of some parameters for fitting in mice is unknown. Here, we developed a computational model in mice for spontaneous metastasis to simulate the process of tumor metastasis based on the mathematical frameworks...
March 14, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29550212/urinary-incontinence-among-adolescent-female-athletes
#8
Bridget Linehan Logan, Lynn Foster-Johnson, Eleni Zotos
BACKGROUND: A collection of studies have demonstrated that approximately one-third of female nulliparous athletes experience urinary incontinence during their athletic activities. Contributing factors of incontinence that have thus far been the focus of study include type of sport, duration and intensity of athletic activity, use of hormonal contraception, and weight. There has, as yet, been a notable underemphasis on several other factors which influence incontinence, including bowel pattern, urinary habits, and menstrual status...
February 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29535303/author-correction-nuclear-lamin-a-c-harnesses-the-perinuclear-apical-actin-cables-to-protect-nuclear-morphology
#9
Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W Schafer, Denis Wirtz, Dong-Hwee Kim
In the original version of this Article, the affiliation details for Arghavan Louhghalam were incorrectly given as 'Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, 21218, USA', and it should have been given as 'Department of Civil and Environmental Engineering, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA'. Furthermore, an incorrect grant number, R1610512, was acknowledged. The correct grant number is NRF-2016R1C1B2015018. These errors have now been corrected in both the PDF and HTML versions of the Article...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29534956/effectiveness-of-implemented-interventions-on-pathologic-nodal-staging-of-non-small-cell-lung-cancer
#10
Meredith A Ray, Nicholas R Faris, Matthew P Smeltzer, Carrie Fehnel, Cheryl Houston-Harris, Paul Levy, Lynn Wiggins, Vishal Sachdev, Todd Robbins, David Spencer, Raymond U Osarogiagbon
BACKGROUND: Accurate pathologic nodal staging improves early-stage non-small-cell lung cancer survival. In an ongoing implementation study, we measured the impact of a surgical lymph node specimen collection kit and a more thorough pathologic gross dissection method, on attainment of guideline-recommended pathologic nodal staging quality. METHODS: We prospectively collected data on curative-intent non-small cell lung cancer resections from 2009-2016 from 11 hospitals in 4 contiguous Dartmouth Hospital Referral Regions...
March 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29513391/association-between-lifestyle-and-overall-health-in-high-school-children-results-from-the-toyama-birth-cohort-study-japan
#11
Weixiu Li, Michikazu Sekine, Masaaki Yamada, Yuko Fujimura, Takashi Tatsuse
BACKGROUND: To investigate the relationship between lifestyle and overall health in high school children. METHODS: Subjects were from the Toyama Birth Cohort Study, a prospective, longitudinal study of children who were born between 1989 and 1990, lived in Toyama Prefecture, Japan, at the time of the survey. This investigation used data from Phase 5 of the Birth Cohort Study, which was conducted in 2005, when the children were in high school. Participants included 4966 children (2449 boys and 2517 girls) aged 15-16 years old...
March 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29490469/vitamin-d-3-supplementation-in-adults-with-bronchiectasis-a-pilot-study
#12
Jim Bartley, Jeff Garrett, Carlos A Camargo, Robert Scragg, Alain Vandal, Rose Sisk, David Milne, Ray Tai, Gene Jeon, Ray Cursons, Conroy Wong
Vitamin D supplementation prevents acute respiratory infections and, through modulating innate and adaptive immunity, could have a potential role in bronchiectasis management. The primary aims of this pilot study were to assess serum 25-hydroxyvitamin D (25(OH)D) levels in New Zealand adults with bronchiectasis, and their 25(OH)D levels after vitamin D3 supplementation. Adults with bronchiectasis received an initial 2.5 mg vitamin D3 oral loading dose and 0.625 mg vitamin D3 weekly for 24 weeks. The primary outcome was serum 25(OH)D levels before and after vitamin D3 supplementation...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29488621/impact-of-in-hospital-death-on-spending-for-bereaved-spouses
#13
Katherine A Ornstein, Melissa M Garrido, Albert L Siu, Evan Bollens-Lund, Kenneth M Langa, Amy S Kelley
OBJECTIVE: To examine how patients' location of death relates to health care utilization and spending for surviving spouses. DATA SOURCES/STUDY SETTING: Health and Retirement Study (HRS) 2000-2012 linked to the Dartmouth Atlas and Medicare claims data. STUDY DESIGN: This was an observational study. We matched bereaved spouses whose spouses died in a hospital to those whose spouses died outside the hospital using propensity scores based on decedent and spouse demographic and clinical characteristics, care preferences, and regional practice patterns...
February 28, 2018: Health Services Research
https://www.readbyqxmd.com/read/29437756/pre-post-mixed-methods-feasibility-study-of-the-workingwell-mobile-support-tool-for-individuals-with-serious-mental-illness-in-the-usa-a-pilot-study-protocol
#14
Joanne Nicholson, Spenser M Wright, Alyssa M Carlisle
INTRODUCTION: Successful competitive employment has been found to be related to enhanced self-esteem, higher quality of life and reduced mental health service use for individuals living with serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression. The effectiveness of the individual placement and support model has been demonstrated in multiple randomised controlled trials in many countries. The management of stress, depression and anxiety in the workplace may be effectively enhanced through digital mental health interventions...
February 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29427207/analysis-of-flood-inundation-in-ungauged-basins-based-on-multi-source-remote-sensing-data
#15
Wei Gao, Qiu Shen, Yuehua Zhou, Xin Li
Floods are among the most expensive natural hazards experienced in many places of the world and can result in heavy losses of life and economic damages. The objective of this study is to analyze flood inundation in ungauged basins by performing near-real-time detection with flood extent and depth based on multi-source remote sensing data. Via spatial distribution analysis of flood extent and depth in a time series, the inundation condition and the characteristics of flood disaster can be reflected. The results show that the multi-source remote sensing data can make up the lack of hydrological data in ungauged basins, which is helpful to reconstruct hydrological sequence; the combination of MODIS (moderate-resolution imaging spectroradiometer) surface reflectance productions and the DFO (Dartmouth Flood Observatory) flood database can achieve the macro-dynamic monitoring of the flood inundation in ungauged basins, and then the differential technique of high-resolution optical and microwave images before and after floods can be used to calculate flood extent to reflect spatial changes of inundation; the monitoring algorithm for the flood depth combining RS and GIS is simple and easy and can quickly calculate the depth with a known flood extent that is obtained from remote sensing images in ungauged basins...
February 9, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29382270/promoting-innovation-enhancing-transdisciplinary-opportunities-for-medical-and-engineering-students
#16
Tiffany Brazile, Glenda Hostetter Shoop, Christine M McDonough, Douglas W Van Citters
PURPOSE: Addressing current healthcare challenges requires innovation and collaboration. Current literature provides limited guidance in promoting these skills in medical school. One approach involves transdisciplinary training in which students from different disciplines work together toward a shared goal. We assessed the need for such a curriculum at Dartmouth College. METHODS: We surveyed medical and engineering students' educational values; learning experiences; professional goals; and interest in transdisciplinary education and innovation...
January 30, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29364724/trends-and-variation-in-the-utilization-and-diagnostic-yield-of-chest-imaging-for-medicare-patients-with-suspected-pulmonary-embolism-in-the-emergency-department
#17
Arjun K Venkatesh, Leila Agha, Jason Abaluck, Craig Rothenberg, Christopher Kabrhel, Ali S Raja
OBJECTIVE: The purpose of this study is to assess trends and variation in chest CT utilization in the emergency department (ED) and its diagnostic yield for suspected pulmonary embolism (PE) among a national sample of Medicare beneficiaries. The relationship between hospital and provider characteristics is also discussed. MATERIALS AND METHODS: We conducted an observational analysis of Medicare beneficiaries evaluated in the ED for suspected PE from 2000 to 2009...
March 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29360996/feature-specific-quantile-normalization-enables-cross-platform-classification-of-molecular-subtypes-using-gene-expression-data
#18
Jennifer M Franks, Guoshuai Cai, Michael L Whitfield
Motivation: Molecular subtypes of cancers and autoimmune disease, defined by transcriptomic profiling, have provided insight into disease pathogenesis, molecular heterogeneity, and therapeutic responses. However, technical biases inherent to different gene expression profiling platforms present a unique problem when analyzing data generated from different studies. Currently, there is a lack of effective methods designed to eliminate platform-based bias. We present a method to normalize and classify RNA-seq data using machine learning classifiers trained on DNA microarray data and molecular subtypes in two datasets: breast invasive carcinoma (BRCA) and colorectal cancer (CRC)...
January 17, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29351776/readmission-rates-in-not-for-profit-vs-proprietary-hospitals-before-and-after-the-hospital-readmission-reduction-program-implementation
#19
Lauren E Birmingham, Willie H Oglesby
BACKGROUND: The Patient Protection and Affordable Care Act established the Hospital Readmission Reduction Program (HRRP) to penalize hospitals with excessive 30-day hospital readmissions of Medicare enrollees for specific conditions. This policy was aimed at increasing the quality of care delivered to patients and decreasing the amount of money paid for potentially preventable hospital readmissions. While it has been established that the number of 30-day hospital readmissions decreased after program implementation, it is unknown whether this effect occurred equally between not-for-profit and proprietary hospitals...
January 19, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29316924/association-of-hospice-utilization-and-publicly-reported-outcomes-following-hospitalization-for-pneumonia-or-heart-failure-a-retrospective-cohort-study
#20
Soowhan Lah, Emily L Wilson, Sarah Beesley, Iftach Sagy, James Orme, Victor Novack, Samuel M Brown
BACKGROUND: The Center for Medicare and Medicaid Services (CMS) and the Hospital Quality Alliance began collecting and reporting United States hospital performance in the treatment of pneumonia and heart failure in 2008. Whether the utilization of hospice might affect CMS-reported mortality and readmission rates is not known. METHODS: Hospice utilization (mean days on hospice per decedent) for 2012 from the Dartmouth Atlas (a project of the Dartmouth Institute that reports a variety of public health and policy-related statistics) was merged with hospital-level 30-day mortality and readmission rates for pneumonia and heart failure from CMS...
January 9, 2018: BMC Health Services Research
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