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Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W Schafer, Denis Wirtz, Dong-Hwee Kim
In the original version of this Article, the affiliation details for Arghavan Louhghalam were incorrectly given as 'Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, 21218, USA', and it should have been given as 'Department of Civil and Environmental Engineering, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA'. Furthermore, an incorrect grant number, R1610512, was acknowledged. The correct grant number is NRF-2016R1C1B2015018. These errors have now been corrected in both the PDF and HTML versions of the Article...
March 13, 2018: Nature Communications
Meredith A Ray, Nicholas R Faris, Matthew P Smeltzer, Carrie Fehnel, Cheryl Houston-Harris, Paul Levy, Lynn Wiggins, Vishal Sachdev, Todd Robbins, David Spencer, Raymond U Osarogiagbon
BACKGROUND: Accurate pathologic nodal staging improves early-stage non-small-cell lung cancer survival. In an ongoing implementation study, we measured the impact of a surgical lymph node specimen collection kit and a more thorough pathologic gross dissection method, on attainment of guideline-recommended pathologic nodal staging quality. METHODS: We prospectively collected data on curative-intent non-small cell lung cancer resections from 2009-2016 from 11 hospitals in 4 contiguous Dartmouth Hospital Referral Regions...
March 10, 2018: Annals of Thoracic Surgery
Weixiu Li, Michikazu Sekine, Masaaki Yamada, Yuko Fujimura, Takashi Tatsuse
BACKGROUND: To investigate the relationship between lifestyle and overall health in high school children. METHODS: Subjects were from the Toyama Birth Cohort Study, a prospective, longitudinal study of children who were born between 1989 and 1990, lived in Toyama Prefecture, Japan, at the time of the survey. This investigation used data from Phase 5 of the Birth Cohort Study, which was conducted in 2005, when the children were in high school. Participants included 4966 children (2449 boys and 2517 girls) aged 15-16 years old...
March 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Jim Bartley, Jeff Garrett, Carlos A Camargo, Robert Scragg, Alain Vandal, Rose Sisk, David Milne, Ray Tai, Gene Jeon, Ray Cursons, Conroy Wong
Vitamin D supplementation prevents acute respiratory infections and, through modulating innate and adaptive immunity, could have a potential role in bronchiectasis management. The primary aims of this pilot study were to assess serum 25-hydroxyvitamin D (25(OH)D) levels in New Zealand adults with bronchiectasis, and their 25(OH)D levels after vitamin D3 supplementation. Adults with bronchiectasis received an initial 2.5 mg vitamin D3 oral loading dose and 0.625 mg vitamin D3 weekly for 24 weeks. The primary outcome was serum 25(OH)D levels before and after vitamin D3 supplementation...
January 1, 2018: Chronic Respiratory Disease
Katherine A Ornstein, Melissa M Garrido, Albert L Siu, Evan Bollens-Lund, Kenneth M Langa, Amy S Kelley
OBJECTIVE: To examine how patients' location of death relates to health care utilization and spending for surviving spouses. DATA SOURCES/STUDY SETTING: Health and Retirement Study (HRS) 2000-2012 linked to the Dartmouth Atlas and Medicare claims data. STUDY DESIGN: This was an observational study. We matched bereaved spouses whose spouses died in a hospital to those whose spouses died outside the hospital using propensity scores based on decedent and spouse demographic and clinical characteristics, care preferences, and regional practice patterns...
February 28, 2018: Health Services Research
Joanne Nicholson, Spenser M Wright, Alyssa M Carlisle
INTRODUCTION: Successful competitive employment has been found to be related to enhanced self-esteem, higher quality of life and reduced mental health service use for individuals living with serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression. The effectiveness of the individual placement and support model has been demonstrated in multiple randomised controlled trials in many countries. The management of stress, depression and anxiety in the workplace may be effectively enhanced through digital mental health interventions...
February 6, 2018: BMJ Open
Wei Gao, Qiu Shen, Yuehua Zhou, Xin Li
Floods are among the most expensive natural hazards experienced in many places of the world and can result in heavy losses of life and economic damages. The objective of this study is to analyze flood inundation in ungauged basins by performing near-real-time detection with flood extent and depth based on multi-source remote sensing data. Via spatial distribution analysis of flood extent and depth in a time series, the inundation condition and the characteristics of flood disaster can be reflected. The results show that the multi-source remote sensing data can make up the lack of hydrological data in ungauged basins, which is helpful to reconstruct hydrological sequence; the combination of MODIS (moderate-resolution imaging spectroradiometer) surface reflectance productions and the DFO (Dartmouth Flood Observatory) flood database can achieve the macro-dynamic monitoring of the flood inundation in ungauged basins, and then the differential technique of high-resolution optical and microwave images before and after floods can be used to calculate flood extent to reflect spatial changes of inundation; the monitoring algorithm for the flood depth combining RS and GIS is simple and easy and can quickly calculate the depth with a known flood extent that is obtained from remote sensing images in ungauged basins...
February 9, 2018: Environmental Monitoring and Assessment
Tiffany Brazile, Glenda Hostetter Shoop, Christine M McDonough, Douglas W Van Citters
PURPOSE: Addressing current healthcare challenges requires innovation and collaboration. Current literature provides limited guidance in promoting these skills in medical school. One approach involves transdisciplinary training in which students from different disciplines work together toward a shared goal. We assessed the need for such a curriculum at Dartmouth College. METHODS: We surveyed medical and engineering students' educational values; learning experiences; professional goals; and interest in transdisciplinary education and innovation...
January 30, 2018: Medical Teacher
Arjun K Venkatesh, Leila Agha, Jason Abaluck, Craig Rothenberg, Christopher Kabrhel, Ali S Raja
OBJECTIVE: The purpose of this study is to assess trends and variation in chest CT utilization in the emergency department (ED) and its diagnostic yield for suspected pulmonary embolism (PE) among a national sample of Medicare beneficiaries. The relationship between hospital and provider characteristics is also discussed. MATERIALS AND METHODS: We conducted an observational analysis of Medicare beneficiaries evaluated in the ED for suspected PE from 2000 to 2009...
January 24, 2018: AJR. American Journal of Roentgenology
Jennifer M Franks, Guoshuai Cai, Michael L Whitfield
Motivation: Molecular subtypes of cancers and autoimmune disease, defined by transcriptomic profiling, have provided insight into disease pathogenesis, molecular heterogeneity, and therapeutic responses. However, technical biases inherent to different gene expression profiling platforms present a unique problem when analyzing data generated from different studies. Currently, there is a lack of effective methods designed to eliminate platform-based bias. We present a method to normalize and classify RNA-seq data using machine learning classifiers trained on DNA microarray data and molecular subtypes in two datasets: breast invasive carcinoma (BRCA) and colorectal cancer (CRC)...
January 17, 2018: Bioinformatics
Lauren E Birmingham, Willie H Oglesby
BACKGROUND: The Patient Protection and Affordable Care Act established the Hospital Readmission Reduction Program (HRRP) to penalize hospitals with excessive 30-day hospital readmissions of Medicare enrollees for specific conditions. This policy was aimed at increasing the quality of care delivered to patients and decreasing the amount of money paid for potentially preventable hospital readmissions. While it has been established that the number of 30-day hospital readmissions decreased after program implementation, it is unknown whether this effect occurred equally between not-for-profit and proprietary hospitals...
January 19, 2018: BMC Health Services Research
Soowhan Lah, Emily L Wilson, Sarah Beesley, Iftach Sagy, James Orme, Victor Novack, Samuel M Brown
BACKGROUND: The Center for Medicare and Medicaid Services (CMS) and the Hospital Quality Alliance began collecting and reporting United States hospital performance in the treatment of pneumonia and heart failure in 2008. Whether the utilization of hospice might affect CMS-reported mortality and readmission rates is not known. METHODS: Hospice utilization (mean days on hospice per decedent) for 2012 from the Dartmouth Atlas (a project of the Dartmouth Institute that reports a variety of public health and policy-related statistics) was merged with hospital-level 30-day mortality and readmission rates for pneumonia and heart failure from CMS...
January 9, 2018: BMC Health Services Research
Eva H DuGoff, Juhee Cho, Yajuan Si, Craig Evan Pollack
Care coordination may be more challenging when the specific physicians with whom primary care physicians (PCPs) are expected to coordinate care change over time. Using Medicare data on physician patient-sharing relationships and the Dartmouth Atlas, we explored the extent to which PCPs tend to share patients with other physicians over time. We found that 70.7% of ties between PCPs and other physicians that were present in 2012 persisted in 2013, and additional shared patients in 2012 increased the odds of being connected in 2013...
March 1, 2017: Medical Care Research and Review: MCRR
Glen P Mays, Cezar B Mamaril
OBJECTIVE: To examine whether local expenditures for public health activities influence area-level medical spending for Medicare beneficiaries. DATA SOURCES AND SETTING: Six census surveys of the nation's 2,900 local public health agencies were conducted between 1993 and 2013, linked with contemporaneous information on population demographics, socioeconomic characteristics, and area-level Medicare spending estimates from the Dartmouth Atlas of Health Care. DATA COLLECTION/EXTRACTION: Measures derive from agency survey data and aggregated Medicare claims...
December 2017: Health Services Research
Jeffrey M Trujillo, Mary E Logue, Ryan Kunkel, Christopher P Demas
Surgical site infections account for about 17% of all nosocomial infections, second only to urinary tract infections. Antibiotic beads deliver high local antibiotic concentrations and maintain low systemic levels. The authors assessed the efficacy of calcium sulfate absorbable antibiotic beads (CSAAB) in the prevention of surgical site infections (SSIs) for complex wound closures. Patient records from the University of New Mexico Hospital (UNMH; Albuquerque, NM) and Dartmouth-Hitchcock Medical Center (DHMC; Lebanon, NH) were retrospectively analyzed from 2004 to 2015...
October 2017: Wounds: a Compendium of Clinical Research and Practice
Katja Koeppen, Bruce A Stanton, Thomas H Hampton
Summary: Current options to mine publicly available gene expression data deposited in NCBI's gene expression omnibus (GEO), such as the GEO web portal and related applications, are optimized to reanalyze a single study, or search for a single gene, and therefore require manual intervention to reanalyze multiple studies for user-specified gene sets. ScanGEO is a simple, user-friendly Shiny web application designed to identify differentially expressed genes across all GEO studies matching user-specified criteria, for a flexible set of genes, visualize results and provide summary statistics and other reports using a single command...
November 1, 2017: Bioinformatics
Matthew P Smeltzer, Nicholas R Faris, Meredith A Ray, Raymond U Osarogiagbon
Importance: Pathologic nodal stage is the most significant prognostic factor in resectable non-small cell lung cancer (NSCLC). The International Association for the Study of Lung Cancer NSCLC staging project revealed intercontinental differences in N category-stratified survival. These differences may indicate differences not only in cancer biology but also in the thoroughness of the nodal examination. Objective: To determine whether survival was affected by sequentially more stringent definitions of pN staging quality in a cohort of patients with NSCLC after resection with curative intent...
September 28, 2017: JAMA Oncology
Kazuaki Takabe
Surgeons in the US are trained to be leaders during their surgical residencies as part of their postgraduate education. Leadership is considered to be essential, since the surgeon directs the medical team. Every surgeon is expected to gain leadership skills. I would like to introduce the leadership training that I received as an ASCO Leadership Development Program graduate and as a Scholarship recipient of Geisel Leadership Course at Dartmouth in addition to General Surgery Residency at University of California San Diego...
2017: Keio Journal of Medicine
William A Nelson, Rachel C Forcino, Glyn Elwyn
Health care organizations have embraced the concept of patient-centered care, but there is concern that the mere inclusion of those words in mission and value statements does not equate to implementation at the health care delivery level. Despite initiatives to align the patient-clinician encounter with broader patient-centered values, there have been mixed results, often creating a gap between practice and the organization's stated position. This preliminary study aims to assess the extent to which patient-centered values are reflected in actual patient care...
October 2017: Health Care Manager
David Bligh, Dylan Dingwell
A water recycling system was installed at the Nova Scotia Hospital Central Laundry in Dartmouth, Nova Scotia in the spring of 2014. The consequent reductions in the consumption of water and steam at this facility have been measured over a 20-month period and are presented here in nominal units and as a financial analysis. Cumulative savings over this period have been calculated to be $351,567, representing a 53% annual return on investment after accounting for annual operating and maintenance costs.
March 2017: Healthcare Management Forum
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