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https://www.readbyqxmd.com/read/29759030/development-of-human-derived-cell-culture-lines-for-recurrent-respiratory-papillomatosis
#1
James Attra, Li-En Hsieh, Linda Luo, Jun Qin Mo, Matthew Brigger, Yu-Tsueng Liu, Seth Pransky
Recurrent respiratory papillomatosis (RRP) is mainly caused by human papillomavirus (HPV) 6 and 11. While various adjuvant therapies have been reported, no effective therapy has been documented to universally "cure" this disease. In the era of precision medicine, it would be valuable to identify effective intervention based on drug sensitivity testing and/or molecular analysis. It is essential to be able to successfully carry out in vitro culture and expand tumor cells directly from patients to accomplish this goal...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29757556/-clinical-curative-effect-and-changes-of-serum-immunology-of-traditional-chinese-medicine-combined-with-surgical-treatment-on-the-adult-onset-recurrent-respiratory-papillomatosis
#2
Hui Wang, Jun Wang, Yang Xiao
Objective: To observe the outcomes of Traditional Chinese Medicine combined with CO_2 laser surgery on the clinical course and serum immunological indexes of Adult onset Recurrent Respiratory Papillomatosis. Method: 69 cases of adult recurrent respiratory papilloma patients who enrolled in Beijing Tongren Hospital from September 2014 to March 2016 were divided randomly into two groups.The Chinese medicine surgery group were treated with traditional Chinese medicine combined with CO_2 laser surgery and the surgery group were treated with CO_2 laser surgery alone...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29756727/-laryngeal-papillomatosis-a-rare-cause-of-dysphonia-in-the-child-case-series
#3
Giselle Cuestas, Verónica Rodríguez, Flavia Doormann, Patricio Bellia Munzón, Gastón Bellia Munzón
Juvenile laryngeal papillomatosis is an uncommon disease caused by human papilloma virus, mainly types 6 and 11. It is the most common benign laryngeal tumor in children. This condition should be suspected in any children with persistent and progressive dysphonia with or without stridor and respiratory distress. Flexible laryngoscopy under local anesthesia allows to visualize the typical wart-like lesions. The diagnosis is confirmed by pathological anatomy. Existing treatment is palliative and consists mainly of the surgical excision of the papillomas to maintain the airway without obstruction and to improve the quality of the voice, but it has a high rate of relapse...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#4
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29713886/comparison-of-narrow-band-imaging-and-the-storz-professional-image-enhancement-system-for-detection-of-laryngeal-and-hypopharyngeal-pathologies
#5
L Staníková, R Walderová, D Jančatová, M Formánek, K Zeleník, Pavel Komínek
OBJECTIVE: The aim of this study was to compare narrow band imaging (NBI) endoscopy and Storz Professional Image Enhancement System (SPIES) in observing epithelial and/or subepithelial microvascular irregularities and pathologies. METHODS: A total of 73 patients with laryngeal or hypopharyngeal lesions were investigated using high-definition NBI endoscopy preoperatively in local anesthesia and using SPIES system intraoperatively in general anesthesia from August 2016 to October 2017...
April 30, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29605367/clinical-and-sociodemographic-characteristics-associated-with-disease-severity-in-juvenile-recurrent-respiratory-papillomatosis-a-study-of-104-patients-in-a-tertiary-care-pediatric-hospital
#6
Lee Marvin Reyes, Juan León Aguilar, Perla Villamor, Carlos De La Torre, Alicia Álvarez, Edgar Mantilla, Hiram Álvarez-Neri
BACKGROUND: Juvenile recurrent respiratory papillomatosis (JRRP) is generally aggressive and with a high recurrence rate. Currently, there is no definite curative treatment for JRRP. Therefore, a greater understanding of the aspects that influence the severity and prognosis of the disease is required. OBJECTIVE: The aim of this study was to establish the clinical and socioeconomic characteristics of pediatric patients with JRRP and its relationship with the severity of the disease in a tertiary care pediatric hospital...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29594918/squamous-cell-papillomatosis-in-the-setting-of-recurrent-respiratory-papillomatosis
#7
Pasha L Bentley, Michael J Coulter, Brenda L Nelson
A 23 year old male presented to the Otolaryngology clinic with 6 months of hoarseness and poor voice projection without improvement from speech therapy or medical anti-reflux medication. Upon examination he was found to have multiple polypoid lesions emanating from bilateral false vocal folds, left true vocal fold, and the anterior commissure. Biopsy and potassium titanyl phosphate (KTP) laser ablation with bevacizumab injection provided treatment and confirmed the clinical suspicion of squamous cell papilloma...
March 28, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29525139/transoral-robotic-excision-of-laryngeal-papillomas-with-flex%C3%A2-robotic-system-a-novel-surgical-approach
#8
Bernar Tan Wen Sheng, Patrick Wong, Constance Teo Ee Hoon
INTRODUCTION: Recurrent respiratory papillomatosis results in hoarseness, stridor and airway obstruction. Management is surgical, with most surgeons using microdebrider or laser. Transoral robotic surgery (TORS) has been successfully utilised for the excision of oropharyngeal malignancies and paediatric airway surgery. This is the first case report of TORS being used for the excision of laryngeal papillomas. CASE REPORT: A 36 year old Chinese female was diagnosed with juvenile onset recurrent respiratory papillomatosis...
May 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29492465/current-and-future-management-of-recurrent-respiratory-papillomatosis
#9
REVIEW
Ryan Ivancic, Hassan Iqbal, Brad deSilva, Quintin Pan, Laura Matrka
Objectives: Recurrent respiratory papillomatosis (RRP) is a chronic disease of the respiratory tract that occurs in both children and adults. It is caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11, and aggressiveness varies among patients. RRP remains a chronic disease that is difficult to manage. This review provides perspectives on current and future management of RRP. Results: The current standard of care is surgical excision, with adjuvant therapies as needed...
February 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29416764/characterization-of-the-effects-of-defined-multidimensional-culture-conditions-on-conditionally-reprogrammed-primary-human-prostate-cells
#10
Lucas Tricoli, Aisha Naeem, Erika Parasido, John P Mikhaiel, Muhammad Umer Choudhry, Deborah L Berry, Iman A Abdelgawad, Richard J Lee, Adam S Feldman, Chukwuemeka Ihemelandu, Maria Avantaggiati, Deepak Kumar, Stephen Byers, Rosa Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Olga Rodriguez, Chris Albanese
The inability to propagate human prostate epithelial cells indefinitely has historically presented a serious impediment to prostate cancer research. The conditionally reprogrammed cell (CRC) approach uses the combination of irradiated J2 mouse fibroblasts and a Rho kinase inhibitor such as Y27632 to support the continuous culture of cells derived from most epithelial tissues, including the prostate. Due to their rapid establishment and overall ease of use, CRCs are now widely used in a variety of basic and preclinical settings...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29394164/obstructing-respiratory-papillomatosis
#11
Neal S Gerstein, Michael F Spafford
No abstract text is available yet for this article.
February 2, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29380936/a-retrospective-case-control-analysis-of-the-efficacy-of-gardasil-%C3%A2-vaccination-in-28-patients-with-recurrent-respiratory-papillomatosis-of-the-larynx
#12
LETTER
T D Milner, A Harrison, J Montgomery, F B MacGregor, M A Buchanan, K MacKenzie
No abstract text is available yet for this article.
January 30, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29378664/the-prevalence-of-human-papillomavirus-in-pediatric-tonsils-a-systematic-review-of-the-literature
#13
REVIEW
Monika Wojtera, Josee Paradis, Murad Husein, Anthony C Nichols, John W Barrett, Marina I Salvadori, Julie E Strychowsky
BACKGROUND: HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remains poorly defined. The objective of this study was to systematically review and evaluate the prevalence and distribution of HPV in the tonsils of pediatric patients undergoing routine tonsillectomy. METHODS AND RESULTS: The literature was searched using PubMed, EMBASE, Scopus, CINAHL, Cochrane Library, and ProQuest Dissertations & Theses Global databases (inception to December 2017) by two independent review authors...
January 30, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29377990/hpviewer-sensitive-and-specific-genotyping-of-human-papillomavirus-in-metagenomic-dna
#14
Yuhan Hao, Liying Yang, Antonio Galvao Neto, Milan R Amin, Dervla Kelly, Stuart M Brown, Ryan C Branski, Zhiheng Pei
Motivation: Shotgun DNA sequencing provides sensitive detection of all 182 HPV types in tissue and body fluid. However, existing computational methods either produce false positives misidentifying HPV types due to shared sequences among HPV, human, and prokaryotes, or produce false negative since they identify HPV by assembled contigs requiring large abundant of HPV reads. Results: We designed HPViewer with two custom HPV reference databases masking simple repeats and homology sequences respectively and one homology distance matrix to hybridize these two databases...
January 25, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29364999/laryngotracheobronchial-papillomatosis-chest-ct-findings
#15
Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Klaus Loureiro Irion, Carolina Althoff Souza, Edson Marchiori
To evaluate the findings on chest CTs in 16 patients (8 men and 8 women) with laryngotracheobronchial papillomatosis. This was a retrospective study involving patients ranging from 2 to 72 years of age. The evaluation of the CT scans was independently performed by two observers, and discordant results were resolved by consensus. The inclusion criteria were presence of abnormalities on the CT scans, and the diagnosis was confirmed by anatomopathological examination of the papillomatous lesions. The most common symptoms were hoarseness, cough, dyspnea, and recurrent respiratory infections...
July 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29333841/-granular-cell-tumor-of-the-larynx-in-the-child-case-report
#16
Giselle Cuestas, Verónica Rodríguez, Flavia Doormann, Patricio Bellia Munzón, Gastón Bellia Munzón
Laryngeal tumors are uncommon in children, accounting only for 2% of the laryngeal anomalies. Ninety-eight percent are benign; the most frequent ones are recurrent respiratory papillomatosis and haemangioma. Granular cell tumor, also called Abrikossoff tumor, is an unusual benign neoplasm, especially in the larynx. Clinical manifestations depend on the size and location of the tumor. Dysphonia is the main presenting symptom. The diagnosis is confirmed by the biopsy. The treatment of choice is surgery. We present a 9-year-old girl with dysphonia and exertion dyspnea due to a granular cell tumor of the larynx, and we emphasize the importance of considering the endoscopic evaluation of the airway in every child with progressive or persistent dysphonia in order to determine the etiology...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29206094/long-term-follow-up-and-outcome-in-patients-with-recurrent-respiratory-laryngeal-papillomatosis
#17
Eva Rye Rasmussen, Didde T Schnack, Andreas Schjellerup Jørkov, Anna Axelsson Raja, Caroline Holkmann Olsen, Preben Homøe
INTRODUCTION: Recurrent respiratory papillomatosis is characterized by wart-like lesions of the upper airway and is most frequently caused by human papillomavirus (HPV). The disease has significant impact on quality of life due to potential airway obstruction, dysphonia and the need for serial surgeries. The main objective of this study was to describe patient characteristics and long-term follow-up data in a Danish cohort with the disease. METHODS: The study was a longitudinal retrospective cohort-study using data from electronic medical records and a pathology database...
December 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29176357/human-papillomavirus-related-disease-in-pediatrics
#18
Collin Fuller, Eva Hudgins, Nika Finelt
PURPOSE OF REVIEW: Human papillomaviruses (HPVs) account for a number of distinct disease entities in pediatrics, ranging from common warts to the stigmatizing condyloma acuminata to life-threatening respiratory papillomatosis. Although there is still a lack of consensus on treatment for each of these HPV-related diseases, scientific investigation continues to progress. Increasing prevention of HPV-related disease with further vaccination and development of new vaccines continues to be the best medical strategy...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29171656/investigation-of-the-presence-of-hpv-on-ktp-laser-fibers-following-ktp-laser-treatment-of-papilloma
#19
Sonam Dodhia, Peter C Baxter, Fei Ye, Michael J Pitman
OBJECTIVES: Recurrent respiratory papillomatosis is often treated with in-office laser procedures using a potassium titanyl phosphate (KTP) laser transmitted through a laser fiber. Although effective, this procedure has notable downsides, including the possibility of transmitting human papillomavirus (HPV) in the smoke plume and the high cost of these single-use fibers. The objective of this study is to determine if HPV can be detected on a laser fiber after use, with or without sterilization...
November 24, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29136168/a-prospective-study-of-the-incidence-of-juvenile-onset-recurrent-respiratory-papillomatosis-after-implementation-of-a-national-hpv-vaccination-program
#20
Daniel Novakovic, Alan T L Cheng, Yvonne Zurynski, Robert Booy, Paul J Walker, Robert Berkowitz, Henley Harrison, Robert Black, Christopher Perry, Shyan Vijayasekaran, David Wabnitz, Hannah Burns, Sepehr N Tabrizi, Suzanne M Garland, Elizabeth Elliott, Julia M L Brotherton
Background: Recurrent respiratory papillomatosis is a rare but morbid disease caused by human papillomavirus (HPV) types 6 and 11. Infection is preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccination program (females 12-26 years in 2007-2009) in Australia, we established a method to monitor incidence and demographics of juvenile-onset recurrent respiratory papillomatosis (JORRP) cases. Methods: The Australian Paediatric Surveillance Unit undertakes surveillance of rare pediatric diseases by contacting practitioners monthly...
January 4, 2018: Journal of Infectious Diseases
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