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respiratory papillomatosis

M Formánek, D Jančatová, P Komínek, P Matoušek, K Zeleník
OBJECTIVE: The human papillomavirus causes recurrent respiratory papillomatosis. Although human papillomavirus prevalence is high, the incidence of papillomatosis is low. Thus, factors other than human papillomavirus infection probably contribute to recurrent respiratory papillomatosis. This study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis and whether laryngopharyngeal reflux occurs in this group of patients more often...
October 19, 2016: Clinical Otolaryngology
Weixin Cui, Wen Xu, Qingwen Yang, Rong Hu
Juvenile onset current respiratory papillomatosis (JORRP), which is the commonest benign laryngeal disease in children, has not been well investigated. This study aimed at further evaluating the clinical features and surgery for such children with JORRP. Patients diagnosed as JORRP in our department from January 2011 to June 2014 were enrolled, and the demographic and clinical data were collected. All the patients were followed up after surgery, and the recurrences were recorded. A total of 124 patients were included and categorized into low recurrence (<4/year, n = 97) and high recurrence (≥4/year, n = 27) groups based on the recurrence at diagnosis, respectively...
September 14, 2016: European Archives of Oto-rhino-laryngology
Michel R M San Giorgi, Leena-Maija Aaltonen, Heikki Rihkanen, Robin E A Tjon Pian Gi, Bernard F A M van der Laan, Josette E H M Hoekstra-Weebers, Frederik G Dikkers
OBJECTIVE: There is no specific clinical tool for physicians to detect psychosocial and physical distress or health care need in patients with recurrent respiratory papillomatosis (RRP). The main aim of this study is to validate the RRP-adapted Distress Thermometer and Problem List (DT&PL). STUDY DESIGN: Prospective cross-sectional questionnaire research. SETTING: Academic tertiary care medical centers in Groningen, Netherlands, and Helsinki, Finland...
September 6, 2016: Otolaryngology—Head and Neck Surgery
Takeyuki Kono, Haruna Yabe, Kosuke Uno, Koichiro Saito, Kaoru Ogawa
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a benign epithelial tumor that exhibits a high frequency of recurrence. This study assesses the vocal function after laser treatment for RRP, particularly in relation to the frequency of surgery. STUDY DESIGN: Retrospective study. METHODS: Thirty RRP patients who underwent laser surgery that controlled the tumor were included. Preoperative and postoperative Grade, Roughness, Breathiness, Asthenia, and Strain Scale, videostroboscopic findings, aerodynamic and acoustic parameters, and self-assessment questionnaires were measured and compared with an age- and sex-matched control group...
August 12, 2016: Laryngoscope
O M Kolesnikova
We undertook the analysis of genetic polymorphism of the HLADQA1 and DQB1 genes in the patients presenting with recurrent respiratory papillomatosis (n=21) with the use of the multiprimer polymerase chain reaction. The results of the study give evidence that the identification of DQ 2.5 and DQ 7.5 haplotypes encoded by the DQA1 *0501, DQB1 *0201, DQA1 *0505, and DQB1 *0301 alleles as well as the carriage of type 16 human papilloma virus (HPV) in combination with these haplotypes in the patients with recurrent respiratory papillomatosis can be used for the prognostication of the severity of this disease...
2016: Vestnik Otorinolaringologii
Ajay Lall, Kamal Gera, Jaya Kumar
No abstract text is available yet for this article.
September 2016: Journal of Pediatrics
Sok Yan Tay, Abhilash Balakrishnan
BACKGROUND: This case report is interesting as cases of children with laryngeal inflammatory myofibroblastic tumor are not common and previously had been presented as isolated case reports. This is the first case report in Asia describing a laryngeal inflammatory myofibroblastic tumor and its removal using an endoscopic approach. CASE PRESENTATION: Our patient is a 12-year-old Malay girl from Singapore who presented with hoarseness without respiratory distress. The initial impression was that of a granuloma or a papilloma...
2016: Journal of Medical Case Reports
Kevin M Motz, Alexander T Hillel
This review will highlight the indications and benefits of office-based therapy for recurrent respiratory papillomatosis (RRP) and discuss the utilization of photo-dynamic lasers and adjuvant medical therapy in office-based settings. Office-based management of RRP allows for more timely interventions, is preferred by the majority of patients, and negates the risk of general anesthesia. Current literature argues for the utilization of KTP laser over CO2 laser for office-based treatment of RRP. Medical therapies for RRP are limited, but agents such as bevacizumab are promising and have been shown to reduce disease burden...
June 2016: Current Otorhinolaryngology Reports
Ana Gameiro, João Alves, Irene Santo, Jacinta Azevedo
INTRODUCTION: Human papillomavirus infection is the most common sexual transmitted infection in the world, being associated with different diseases, namely anogenital warts, recurrent respiratory papillomatosis and anal, cervical, and oropharyngeal cancers. Among sexually active people, approximately 1% has anogenital warts, 90% of cases resulting from genotypes 6 and 11. MATERIAL AND METHODS: Patients diagnosed with first episode of anogenital warts from 2008 to 2014 in Lisbon's major venereology clinic were identified, and characterized according to sex, sexual orientation, age, warts location, and number of sexual partners...
February 2016: Acta Médica Portuguesa
Zoon Wangu, Katherine K Hsu
Human papillomavirus (HPV), the most common sexually transmitted infection in the US and worldwide, can cause cancers, anogenital warts (AGW), and recurrent respiratory papillomatosis (RRP) in men, women, and children. Global incidence of AGW ranges from 160-289 cases per 100,000 person-years and peaks in young men and women in the third decade of life. RRP has an estimated incidence of 3 per 1 million person-years in children. Pre-licensure trial efficacy, modeling and time-trend ecological studies have shown a significant short-term impact of 4vHPV vaccine...
June 2, 2016: Human Vaccines & Immunotherapeutics
Adam Donne, Kim Keltie, Helen Cole, Andrew Sims, Hannah Patrick, Steve Powell
OBJECTIVES: To estimate the number of patients with recurrent respiratory papillomatosis (RRP) currently managed in secondary and tertiary health care in the UK and the frequency of its treatment with Coblation(™) . DESIGN: Cross-sectional survey of ENT consultants in the UK with validation using Hospital Episode Statistics (HES) inpatient data SETTING: Online survey. PARTICIPANTS: ENT CONSULTANTS IN THE UK: MAIN OUTCOME MEASURES: Number of RRP patients currently managed in acute care in the UK and frequency of use of Coblation...
May 21, 2016: Clinical Otolaryngology
Robin E A Tjon Pian Gi, Michel R M San Giorgi, Michael Pawlita, Angelika Michel, Bettien M van Hemel, Ed M D Schuuring, Edwin R van den Heuvel, Bernard F A M van der Laan, Frederik G Dikkers
Aim of this study was to explore influence of the quadrivalent HPV vaccine (Gardasil(®)) on the immune status of recurrent respiratory papillomatosis (RRP) patients. In retrospective observational study, six RRP patients who received the quadrivalent HPV vaccine and whose HPV seroreactivity was measured were included. Multiplex HPV Serology was used to determine HPV-specific antibodies pre- and post-vaccination. Surgical interventions and patient records were analyzed. Five HPV6 and 1 HPV11 infected patient were included...
October 2016: European Archives of Oto-rhino-laryngology
Michel R M San Giorgi, Herman M Helder, Robbert-Jan S Lindeman, Geertruida H de Bock, Frederik G Dikkers
OBJECTIVES/HYPOTHESIS: Antireflux therapy is incorporated in many treatment protocols for recurrent respiratory papillomatosis (RRP) because gastroesophageal reflux (GERD) is thought to worsen the disease course of RRP. It is unclear if GERD really aggravates the disease course. The aims of this systematic review were to 1) evaluate incidence of GERD among RRP patients and 2) report if GERD changes the clinical course or tissue properties of RRP. STUDY DESIGN: A search was conducted in PubMed, Embase, and Google Scholar, following the methods of Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
October 2016: Laryngoscope
Daniel Novakovic, Alan T L Cheng, Katherine Baguley, Paul Walker, Henley Harrison, Marlene Soma, Michael Malloy, Julia M L Brotherton
OBJECTIVES/HYPOTHESIS: To estimate the prevalence of juvenile onset recurrent respiratory papillomatosis (RRP) in Australia, describe its epidemiological profile, and assess the positive predictive value of International Classification of Disease, 10th revision (ICD-10) code D14.1 (benign neoplasm of larynx) in children for hospitalization due to RRP. STUDY DESIGN: Retrospective case series. METHODS: Retrospective case review undertaken at the three tertiary pediatric hospitals in New South Wales (Australia's largest state), by reviewing medical records of patients aged 0 to 16 years admitted during 2000-2009 containing the ICD-10 Australian modification code D14...
April 14, 2016: Laryngoscope
Carmen S García-Romero, Matsuharu Akaki-Caballero, Ana G Saavedra-Mendoza, Ana K Guzmán-Romero, Patricia Canto, Ramón M Coral-Vázquez
No abstract text is available yet for this article.
June 2016: Auris, Nasus, Larynx
Karen Onyirioha, Luis Seguias
No abstract text is available yet for this article.
March 2016: Pediatric Annals
E S Korovkina, O O Magarshak
A thorough collection of complaints and history data, physical examination, and lung function tests are necessary to confirm the diagnosis of asthma. The latter must be differentiated from different diseases in the majority of patients according to age. Recurrent respiratory papillomatosis is caused by human papillomavirus and involves mainly the upper respiratory tract. The paper describes a case of tracheal papillomatosis concurrent with atopic asthma.
2016: Terapevticheskiĭ Arkhiv
Sharon H Gnagi, Forrest T Gnagi, Scott A Schraff, Michael L Hinni
OBJECTIVE: Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. STUDY DESIGN: Survey. SETTING: Tertiary care academic children's hospital. SUBJECTS: Pediatric residents, fellows, and staff. METHODS: An online survey was made available regarding HPV education and vaccination...
July 2016: Otolaryngology—Head and Neck Surgery
Juliana Sato Hermann, Lily Yin Weckx, Jussimara Monteiro Nürmberger, Gildo Francisco Dos Santos Junior, Antonio Carlos Campos Pignatari, Shirley Shizue Nagata Pignatari
OBJECTIVE: To evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of juvenile-onset recurrent respiratory papillomatosis (RRP) when administered to a group of patients with this condition. METHODS: Uncontrolled intervention study of patients with juvenile-onset RRP examined at the Pediatric Otorhinolaryngology Clinic, Federal University of São Paulo, where nine patients between the ages of nine and 17 received three doses of the prophylactic quadrivalent HPV vaccine (Gardasil(®)) and were followed for one year...
April 2016: International Journal of Pediatric Otorhinolaryngology
R Y Seedat, C E Combrinck, P A Bester, J-Y Lee, F J Burt
Human papillomavirus (HPV) types 6 and 11 are the aetiological agent of recurrent respiratory papillomatosis (RRP). The complete genome of an HPV6 isolate with a 170 base pair (bp) duplication identified within the long control region (LCR) from a patient with aggressive recurrent respiratory papillomatosis was determined. The promoter sequence from the HPV LCR including the 170 bp duplication was placed upstream of a heterologous reporter gene and the activity of the reporter gene product determined using transfected cells...
July 2016: Epidemiology and Infection
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