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IOTA ultrasound

Sudha Sundar, Caroline Rick, Francis Dowling, Pui Au, Kym Snell, Nirmala Rai, Rita Champaneria, Hilary Stobart, Richard Neal, Clare Davenport, Susan Mallett, Andrew Sutton, Sean Kehoe, Dirk Timmerman, Tom Bourne, Ben Van Calster, Aleksandra Gentry-Maharaj, Usha Menon, Jon Deeks
INTRODUCTION: Ovarian cancer (OC) is associated with non-specific symptoms such as bloating, making accurate diagnosis challenging: only 1 in 3 women with OC presents through primary care referral. National Institute for Health and Care Excellence guidelines recommends sequential testing with CA125 and routine ultrasound in primary care. However, these diagnostic tests have limited sensitivity or specificity. Improving accurate triage in women with vague symptoms is likely to improve mortality by streamlining referral and care pathways...
2016: BMJ Open
Juan Luis Alcázar
No abstract text is available yet for this article.
October 2016: Evidence-based Medicine
F Mascilini, L Savelli, M C Scifo, C Exacoustos, I Timor-Tritsch, I De Blasis, M C Moruzzi, T Pasciuto, G Scambia, L Valentin, A C Testa
OBJECTIVES: To elucidate if there are any ultrasound features that can be used to discriminate between benign and malignant cysts with papillary projections but no other solid components in pregnant women. METHODS: Thirty-four women with an ultrasound diagnosis of an ovarian cyst with papillary projections but no other solid components that had been surgically removed during pregnancy were identified from the databases of four ultrasound units. Some clinical and ultrasound information had been collected prospectively...
August 3, 2016: Ultrasound in Obstetrics & Gynecology
Stefano Guerriero, Ben Van Calster, Edgardo Somigliana, Silvia Ajossa, Wouter Froyman, Bavo De Cock, An Coosemans, Daniela Fischerová, Caroline Van Holsbeke, Juan Luis Alcazar, Antonia C Testa, Lil Valentin, Tom Bourne, Dirk Timmerman
STUDY QUESTION: Do sonographic characteristics of ovarian endometriomas vary with age in premenopausal women? SUMMARY ANSWER: With increasing age, multilocular cysts and cysts with papillations and other solid components become more common whereas ground glass echogenicity of cyst fluid becomes less common. WHAT IS KNOWN ALREADY: Expectant or medical management of women with endometriomas is now accepted. Therefore, the accuracy of non-invasive diagnosis of these cysts is pivotal...
August 2016: Human Reproduction
E M J Meys, J Kaijser, R F P M Kruitwagen, B F M Slangen, B Van Calster, B Aertgeerts, J Y Verbakel, D Timmerman, T Van Gorp
INTRODUCTION: Many national guidelines concerning the management of ovarian cancer currently advocate the risk of malignancy index (RMI) to characterise ovarian pathology. However, other methods, such as subjective assessment, International Ovarian Tumour Analysis (IOTA) simple ultrasound-based rules (simple rules) and IOTA logistic regression model 2 (LR2) seem to be superior to the RMI. Our objective was to compare the diagnostic accuracy of subjective assessment, simple rules, LR2 and RMI for differentiating benign from malignant adnexal masses prior to surgery...
May 2016: European Journal of Cancer
Dirk Timmerman, Ben Van Calster, Antonia Testa, Luca Savelli, Daniela Fischerova, Wouter Froyman, Laure Wynants, Caroline Van Holsbeke, Elisabeth Epstein, Dorella Franchi, Jeroen Kaijser, Artur Czekierdowski, Stefano Guerriero, Robert Fruscio, Francesco P G Leone, Alberto Rossi, Chiara Landolfo, Ignace Vergote, Tom Bourne, Lil Valentin
BACKGROUND: Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent metaanalysis concluded that the International Ovarian Tumor Analysis algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. OBJECTIVE: We sought to develop and validate a model to predict the risk of malignancy in adnexal masses using the ultrasound features in the Simple Rules...
April 2016: American Journal of Obstetrics and Gynecology
Almudena Peces Rama, María Carmen Llanos Llanos, María Luisa Sánchez Ferrer, Juan Luis Alcázar Zambrano, Antonio Martínez Mendoza, Aníbal Nieto Díaz
OBJECTIVE: External validation of the IOTA group's three-step diagnostic model (Strategy 1) and comparison with assessment by an expert sonographer (Strategy 2). STUDY DESIGN: Prospective study in patients with persistent adnexal masses, in which an inexperienced sonographer performed transvaginal ultrasound applying simple descriptors (SD) and rules (SR) for classifying as benign or malignant. Any non-classifiable mass was then submitted to an expert examiner for subjective assessment (SA)...
December 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Liliane Silvestre, Wellington P Martins, Francisco J Candido-Dos-Reis
BACKGROUND: This study describes the accuracy of three-dimensional power Doppler (3D-PD) angiography as secondary method for differential diagnosis of ovarian tumors. METHOD: Seventy-five women scheduled for surgical removal of adnexal masses were assessed by transvaginal ultrasound. Ovarian tumors were classified by IOTA simple rules and two three-dimensional blocks were recorded. In a second step analyses, a 4 cm(3) spherical sample was obtained from the highest vascularized solid area of each stored block...
2015: Journal of Ovarian Research
A Knafel, T Banas, A Nocun, M Wiechec, R Jach, A Ludwin, M Kabzinska-Turek, M Pietrus, K Pitynski
Objective: To externally validate the International Ovarian Tumor Analysis (IOTA) Simple Rules (SR) by examiners with different levels of sonographic experience defined by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) and to assess the morphological ultrasound features of the adnexal tumors classified as inconclusive based on IOTA SR. Materials and Methods: In the two-year prospective study adnexal tumors were assessed preoperatively with transvaginal ultrasound by examiners with different levels of experience (level 1- IOTA SR1, level 2-IOTA SR2)...
June 30, 2015: Ultraschall in der Medizin
Dangcheewan Tinnangwattana, Linlada Vichak-Ururote, Paponrad Tontivuthikul, Cholaros Charoenratana, Thitikarn Lerthiranwong, Theera Tongsong
OBJECTIVE: To evaluate the diagnostic performance of IOTA simple rules in predicting malignant adnexal tumors by non-expert examiners. MATERIALS AND METHODS: Five obstetric/gynecologic residents, who had never performed gynecologic ultrasound examination by themselves before, were trained for IOTA simple rules by an experienced examiner. One trained resident performed ultrasound examinations including IOTA simple rules on 100 women, who were scheduled for surgery due to ovarian masses, within 24 hours of surgery...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
J Kaijser
Whilst the outcomes for patients with ovarian cancer clearly benefit from centralised, comprehensive care in dedicated cancer centres, unfortunately the majority of patients still do not receive appropriate specialist treatment. Any improvement in the accuracy of current triaging and referral pathways whether using new imaging tests or biomarkers would therefore be of value in order to optimise the appropriate selection of patients for such care. An analysis of current evidence shows that such tests are now available, but still await recognition, acceptance and widespread adoption...
2015: Facts, Views & Vision in ObGyn
D Fischerová
Transvaginal ultrasonography is the first-line and best imaging technique for characterising adnexal masses preoperatively. The optimal approach is the subjective assessment of ultrasound images by experts. An alternative evidence-based approach to the pre-surgical diagnosis of adnexal tumours is to use simple ultrasound rules or logistic regression model LR2 developed by the International Ovarian Tumor Analysis (IOTA) group. Their test performance matches subjective assessment by experienced examiners and should be adopted as the principal test to characterize masses as benign or malignant...
December 2014: Ceská Gynekologie
Povilas Sladkevicius, Lil Valentin
PURPOSE: To estimate interobserver agreement with regard to describing adnexal masses using the International Ovarian Tumor Analysis (IOTA) terminology and the risk of malignancy calculated using IOTA logistic regression models LR1 and LR2, and to elucidate what explained the largest interobserver differences in calculated risk of malignancy. EXPERIMENTAL DESIGN: One hundred and seventeen women with adnexal masses were examined with transvaginal gray scale and power Doppler ultrasound by two independent experienced sonologists who described the masses using IOTA terminology...
February 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ben Van Calster, Kirsten Van Hoorde, Lil Valentin, Antonia C Testa, Daniela Fischerova, Caroline Van Holsbeke, Luca Savelli, Dorella Franchi, Elisabeth Epstein, Jeroen Kaijser, Vanya Van Belle, Artur Czekierdowski, Stefano Guerriero, Robert Fruscio, Chiara Lanzani, Felice Scala, Tom Bourne, Dirk Timmerman
OBJECTIVES: To develop a risk prediction model to preoperatively discriminate between benign, borderline, stage I invasive, stage II-IV invasive, and secondary metastatic ovarian tumours. DESIGN: Observational diagnostic study using prospectively collected clinical and ultrasound data. SETTING: 24 ultrasound centres in 10 countries. PARTICIPANTS: Women with an ovarian (including para-ovarian and tubal) mass and who underwent a standardised ultrasound examination before surgery...
2014: BMJ: British Medical Journal
A Sayasneh, J Kaijser, J Preisler, A A Smith, F Raslan, S Johnson, R Husicka, L Ferrara, C Stalder, S Ghaem-Maghami, D Timmerman, T Bourne
OBJECTIVES: To assess the diagnostic performance of subjective assessment by Level II ultrasound examiners in predicting the specific histology of adnexal masses. METHODS: The women included in this prospective multicenter cross-sectional study were older than 16 years of age and had at least one adnexal mass. They underwent transvaginal sonography (TVS) performed by Level II examiners, all of whom were familiar with the International Ovarian Tumor Analysis (IOTA) group definitions of ultrasound features of ovarian masses...
May 2015: Ultrasound in Obstetrics & Gynecology
Charuwan Tantipalakorn, Chanane Wanapirak, Surapan Khunamornpong, Kornkanok Sukpan, Theera Tongsong
BACKGROUND: To evaluate the diagnostic performance of IOTA simple rules in differentiating between benign and malignant ovarian tumors. MATERIALS AND METHODS: A study of diagnostic performance was conducted on women scheduled for elective surgery due to ovarian masses between March 2007 and March 2012. All patients underwent ultrasound examination for IOTA simple rules within 24 hours of surgery. All examinations were performed by the authors, who had no any clinical information of the patients, to differentiate between benign and malignant adnexal masses using IOTA simple rules...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
A Testa, J Kaijser, L Wynants, D Fischerova, C Van Holsbeke, D Franchi, L Savelli, E Epstein, A Czekierdowski, S Guerriero, R Fruscio, F P G Leone, I Vergote, T Bourne, L Valentin, B Van Calster, D Timmerman
BACKGROUND: To compare different ultrasound-based international ovarian tumour analysis (IOTA) strategies and risk of malignancy index (RMI) for ovarian cancer diagnosis using a meta-analysis approach of centre-specific data from IOTA3. METHODS: This prospective multicentre diagnostic accuracy study included 2403 patients with 1423 benign and 980 malignant adnexal masses from 2009 until 2012. All patients underwent standardised transvaginal ultrasonography. Test performance of RMI, subjective assessment (SA) of ultrasound findings, two IOTA risk models (LR1 and LR2), and strategies involving combinations of IOTA simple rules (SRs), simple descriptors (SDs) and LR2 with and without SA was estimated using a meta-analysis approach...
August 12, 2014: British Journal of Cancer
N Nunes, G Ambler, X Foo, J Naftalin, M Widschwendter, D Jurkovic
OBJECTIVES: To present data on prospective evaluation of the International Ovarian Tumor Analysis (IOTA) 'simple-rules' tool for the diagnosis of ovarian cancer and to perform a meta-analysis of studies that utilized the same diagnostic method. METHODS: In the present study a level-II ultrasound operator systematically assessed the tumors of women with an ultrasound diagnosis of adnexal tumor(s) according to the IOTA simple-rules protocol to determine the risk of the tumor being malignant...
November 2014: Ultrasound in Obstetrics & Gynecology
E Jansen, S Fransis, S Ahmad, D Timmerman, C Van Holsbeke
The aim of this pictorial essay is to describe the ultrasound characteristics of the mucocele of the appendix (MA) by transvaginal ultrasound. The databases of the pathology and gynaecology departments of two Belgian hospitals were retrospectively searched for all cases of MA. Only patients who received a pre-operative transvaginal ultrasound scan by an experienced ultrasound examiner following the IOTA protocol were included. Ultrasound -characteristics were described and pattern recognition was applied in order to find morphological characteristics typical for MA...
2013: Facts, Views & Vision in ObGyn
F Mascilini, C Moruzzi, C Giansiracusa, F Guastafierro, L Savelli, L De Meis, E Epstein, I E Timor-Tritsch, M Mailath-Pokorny, A Ercoli, C Exacoustos, B R Benacerraf, L Valentin, A C Testa
OBJECTIVES: To describe the clinical history and ultrasound findings in women with decidualized endometriomas surgically removed during pregnancy. METHODS: In this retrospective study, women with a histological diagnosis of decidualized endometrioma during pregnancy who had undergone preoperative ultrasound examination were identified from the databases of seven ultrasound centers. The ultrasound appearance of the tumors was described on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) by one author from each center using the terms and definitions of the International Ovarian Tumor Analysis (IOTA) group...
September 2014: Ultrasound in Obstetrics & Gynecology
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