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https://www.readbyqxmd.com/read/28109199/functional-magnetic-resonance-imaging-in-dermatology-the-skin-the-brain-and-the-invisible
#1
REVIEW
Simon M Mueller, Samuel Hogg, Jannis Mueller, Shane McKie, Peter Itin, Julia Reinhardt, Christopher E M Griffiths, C Elise Kleyn
The skin and brain have a close bi-directional anatomical and functional connection. Historically, the skin-brain axis and the brain-skin axis have been well described. However, brain function in this context has only recently been demystified with the introduction of functional neuroimaging in dermatology. Functional neuroimaging, especially functional magnetic resonance imaging (fMRI), allows indirect visualisation of brain function. This review looks back to the beginnings of functional neuroimaging in dermatology, summarises the currently available dermatology-related fMRI-studies and discusses the potential future role of fMRI as a stratifying tool in clinical dermatology and in the development of novel therapies...
January 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28109167/cell-cycle-tailored-targeting-of-metastatic-melanoma-challenges-opportunities
#2
Nikolas K Haass, Brian Gabrielli
The advent of targeted therapies of metastatic melanoma, such as MAPK pathway inhibitors and immune checkpoint antagonists, has turned dermato-oncology from the 'bad guy' to the 'poster child' in oncology. Current targeted therapies are effective; although here is a clear need to develop combination therapies to delay the onset of resistance. Many anti-melanoma drugs impact on the cell cycle but are also dependent on certain cell cycle phases resulting in cell cycle phase-specific drug insensitivity. Here, we raise the question: Have combination trials been abandoned prematurely as ineffective possibly only because drug scheduling was not optimized? Firstly, if both drugs of a combination hit targets in the same melanoma cell, cell cycle-mediated drug insensitivity should be taken into account when planning combination therapies, timing of dosing schedules and choice of drug therapies in solid tumors...
January 21, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28109137/color-vision-abnormality-as-the-sole-manifestation-of-posterior-reversible-encephalopathy-due-to-post-partum-hellp-syndrome
#3
Hironori Takahashi, Teppei Matsubara, Shinji Makino, Kenji Horie, Shigeki Matsubara
Posterior reversible encephalopathy syndrome (PRES) is associated with several symptoms; of those, visual acuity loss, light oversensitivity (photophobia), and light flashes (photopsia) are known as PRES-related eye symptoms. We report a post-partum woman with PRES associated with hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP), in whom color vision abnormality (achromatopsia) was the sole manifestation. Cesarean section was performed at 28 weeks due to headache, epigastralgia, and severe hypertension...
January 21, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28109134/a-novel-mitochondria-targeting-fluorescent-probe-as-the-monitor-of-hydrogen-sulfide-in-living-cells
#4
Wei Shi, Miaobo Pan, Hao Qiang, Qianqian Qiu, Wenlong Huang, Haiyan Lin, Hai Qian, Liang Ge
A novel mitochondria targeting fluorescent probe compound S-N3 as the monitor of Hydrogen Sulfide (H2 S) in living cells has been designed and synthesized in this paper. This article contained the chemosynthesis and some studies on bioactivity of the target compound in living cells. Compound S-N3 is easy to synthesize and can remain stable under the effect of pH, system and photo. In additional, it shows low cytotoxicity in cell imaging. And it can react with H2 S highly selective in PBS or FBS solution, which would cause the obvious increase of fluorescence intensity...
January 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28109132/echocardiographic-assessment-of-left-ventricular-function-in-healthy-horses-and-in-horses-with-heart-disease-using-pulsed-wave-tissue-doppler-imaging
#5
T R Koenig, K J Mitchell, C C Schwarzwald
BACKGROUND: Assessment of left ventricular (LV) function by tissue Doppler imaging (TDI) is not well established in horses with heart disease. OBJECTIVES: To describe the use of pulsed-wave (PW) TDI for the assessment of LV function, establish reference intervals, investigate effects of mitral regurgitation (MR), aortic regurgitation (AR), and primary myocardial disease (MD), and provide proof of concept for the use of PW TDI in Warmblood horses with heart disease...
January 21, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28109122/bleeding-in-the-retroperitoneal-space-under-the-broad-ligament-as-a-result-of-uterine-perforation-after-dilatation-and-curettage-report-of-a-case
#6
Hisato Tokuda, Satoshi Nakago, Hiroki Kato, Tetsuya Oishi, Fumikazu Kotsuji
Uterine perforation, a complication of dilation and curettage, is typically recognized immediately after the procedure by clinical symptoms of peritoneal irritation resulting from intraperitoneal bleeding. Our patient complained of having an uncomfortable feeling, slight dizziness, palpitation in the sitting position and abdominal discomfort but did not show signs of peritoneal irritation 24 h after dilation and curettage. However, she suddenly complained of abdominal pain. Tenderness and rebound tenderness were detected at the lower abdominal wall...
January 21, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28109112/-targeted-imaging-ability-of-a-biotinylated-imaging-probe-biotin-s-s-rhodol-for-breast-cancer-cells-in-vitro
#7
Bi-Juan Wu, Xing-Zi Zhou, Jing-Wen Sun, Cui-Wen Tan, Xin-Rong Wu
OBJECTIVE: To investigate performance of a biotinylated imaging probe 3a for targeted imaging of breast cancer cells. METHODS: Ultraviolet absorption spectrum and fluorescence spectrum were employed to analyze the spectral characteristics of 3a. The fluorescence spectrums of 3a treated with different concentrations of glutathione (GSH) were obtained to determine the sensibility of 3a to GSH. Flow cytometry was used to determine the cellular uptake of 3a by MCF-7 cells, MDA-MB-231 cells and Hs 578Bst cells in the presence or absence of biotin, and the imaging performance of 3a in the 3 cell lines was assessed under an inverted fluorescent microscope...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109103/-value-of-diffusion-weighted-imaging-1-h-magnetic-resonance-spectroscopy-and-3d-whole-brain-arterial-spin-labeling-in-the-diagnosis-of-medulloblastoma
#8
Dong-Liang Cheng, Wen-Sheng Wang, Yi-Xin Hu, Meng-Lin Chen, Ge Wen, Li-Na Cheng, Jing Wu, Liu-Qing Yan
OBJECTIVE: To explore the value of diffusion-weighted imaging (DWI), (1)H-magnetic resonance spectroscopy (1H-MRS) and 3D whole-brain arterial spin labeling (3D ASL) in the diagnosis of medulloblastoma in the posterior cranial fossa. METHODS: The magnetic resonance imaging (MRI) findings of 16 patients with pathologically confirmed medulloblastoma in the posterior cranial fossa were analyzed retrospectively. All the patients were examined with plane and enhanced brain MRI scans; 5 patients also underwent examinations with DWI, 12 with MRS, and 5 with 3D ASL...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109090/-three-dimensional-versus-two-dimensional-imaging-systems-in-laparoscopic-radical-prostatectomy-for-prostate-cancer-a-retrospective-cohort-study
#9
Kai-Qiang Tang, Shi-Yu Pang, Ji-Ming Bao, Cheng-Yong Lei, Wan-Long Tan
OBJECTIVE: To compare the perioperative, functional and oncologic outcomes of patients with prostate cancer receiving laparoscopic radical prostatectomy (LRP) using three-dimensional (3D) versus two-dimensional (2D) imaging systems. METHODS: From February, 2014 to January 2016, 72 consecutive patients with clinically localized prostate cancer underwent LRP with 2D or 3D imaging systems performed by a single experienced surgeon. The baseline characteristics, perioperative data, and functional and oncologic outcomes of the patients were collected and analyzed...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109081/shope-fibroma-in-the-external-ear-canal-of-a-domestic-rabbit
#10
Shawna J
A 5-y-old, intact, 2.5-kg female domestic rabbit was presented because of blood spatter on the wall of its cage and thetoenailsof its right hind limb. Physical examination revealed a red, gelatinous mass that spanned the width of the right vertical ear canal. Radiographic images revealed a soft-tissue opacity at the base of the right ear, which was superimposed over the tympanic bulla and extended to the pinna. A CT scan revealed that the soft-tissue mass was within the vertical and horizontal portions of the right external ear canal and extended to the level of the tympanic membrane, with no bony involvement...
January 20, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28109054/intracoronary-optical-coherence-tomography-clinical-and-research-applications-and-intravascular-imaging-software-overview
#11
Erhan Tenekecioglu, Felipe N Albuquerque, Yohei Sotomi, Yaping Zeng, Pannipa Suwannasom, Hiroki Tateishi, Rafael Cavalcante, Yuki Ishibashi, Shimpei Nakatani, Mohammad Abdelghani, Jouke Dijkstra, Christos Bourantas, Carlos Collet, Antonios Karanasos, Maria Radu, Ancong Wang, Takashi Muramatsu, Ulf Landmesser, Takayuki Okamura, Evelyn Regar, Lorenz Räber, Giulio Guagliumi, Robert T Pyo, Yoshinobu Onuma, Patrick W Serruys
By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research applications...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109049/production-of-the-antibiotic-secondary-metabolite-solanapyrone-a-by-the-fungal-plant-pathogen-ascochyta-rabiei-during-fruiting-body-formation-in-saprobic-growth
#12
Wonyong Kim, Jeong-Jin Park, Frank M Dugan, Tobin L Peever, David R Gang, George Vandemark, Weidong Chen
Fungi are noted producers of a diverse array of secondary metabolites, many of which are of pharmacological importance. However, the biological roles of the vast majority of these molecules during the fungal life cycle in nature remain elusive. Solanapyrones are polyketide-derived secondary metabolites produced by diverse fungal species including the plant pathogen Ascochyta rabiei. This molecule was originally thought to function as a phytotoxin facilitating pathogenesis of A. rabiei. Chemical profiling and gene expression studies showed that solanapyrone A was specifically produced during saprobic, but not parasitic growth of A...
January 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28109009/using-flow-characteristics-in-three-dimensional-power-doppler-ultrasound-imaging-to-predict-complete-responses-in-patients-undergoing-neoadjuvant-chemotherapy
#13
Wei-Chung Shia, Yu-Len Huang, Hwa-Koon Wu, Dar-Ren Chen
OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108994/magnetic-resonance-imaging-directed-ultrasound-imaging-of-non-mass-enhancement-in-the-breast-outcomes-and-frequency-of-malignancy
#14
Adrienne R Newburg, Chloe M Chhor, Leng Leng Young Lin, Samantha L Heller, Jennifer Gillman, Hildegard K Toth, Linda Moy
OBJECTIVES: This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. METHODS: From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non-mass enhancing lesions for which follow-up or biopsy was recommended. Retrospective review of the images identified 879 of 918 lesions (96%) meeting criteria for non-mass enhancement...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108988/blood-brain-barrier-closure-time-after-controlled-ultrasound-induced-opening-is-independent-of-opening-volume
#15
Meaghan A O'Reilly, Olivia Hough, Kullervo Hynynen
OBJECTIVES: Microbubble-mediated focused ultrasound (US) opening of the blood-brain barrier (BBB) has shown promising results for the treatment of brain tumors and conditions such as Alzheimer disease. Practical clinical implementation of focused US treatments would aim to treat a substantial portion of the brain; thus, the safety of opening large volumes must be investigated. This study investigated whether the opened volume affects the time for the BBB to be restored after treatment...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108983/shear-wave-elastography-is-a-reliable-and-repeatable-method-for-measuring-the-elastic-modulus-of-the-rectus-femoris-muscle-and-patellar-tendon
#16
Serkan Taş, Mehmet Ruhi Onur, Seval Yılmaz, Abdullah Ruhi Soylu, Feza Korkusuz
OBJECTIVES: The purpose of this study was to determine intraobserver, interobserver, and inter-day reliability levels for stiffness measurements of the patellar tendon and rectus femoris muscle using shear wave elastography (SWE). METHODS: This study was conducted on 12 healthy male individuals. Two examiners measured mean shear wave velocity values of the patellar tendons and rectus femoris muscles of both extremities using a 9L4 (4-9 MHz) transducer and an Acuson S3000 ultrasound system (Siemens Medical Solutions, Mountain View, CA)...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108979/analysis-of-stress-only-imaging-comparing-upright-and-supine-czt-camera-acquisition-to-conventional-gamma-camera-images-with-and-without-attenuation-correction-with-coronary-angiography-as-a-reference
#17
Zenith A Jameria, Mouhamad Abdallah, Mariano Fernandez-Ulloa, Robert O'Donnell, Alok K Dwivedi, Erica Washburn, Naseer Khan, Mahyar Khaleghi, Nischelle Kalakota, Myron C Gerson
BACKGROUND: Diagnostic performance of stress-only imaging using a Cadmium-Zinc-Telluride (CZT) camera has not been directly compared in the same patients to stress-only attenuation-corrected conventional Anger camera images. METHODS: 112 subjects with correlative coronary angiographic data and 40 subjects with <5% pre-test likelihood of coronary disease completed attenuation-corrected stress-only images on a conventional Anger camera and uncorrected upright and supine stress images on a CZT camera...
January 20, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28108975/3d-printed-soft-tissue-physical-models-of-renal-malignancies-for-individualized-surgical-simulation-a-feasibility-study
#18
Michael M Maddox, Allison Feibus, James Liu, Julie Wang, Raju Thomas, Jonathan L Silberstein
To construct patient-specific physical three-dimensional (3D) models of renal units with materials that approximates the properties of renal tissue to allow pre-operative and robotic training surgical simulation, 3D physical kidney models were created (3DSystems, Rock Hill, SC) using computerized tomography to segment structures of interest (parenchyma, vasculature, collection system, and tumor). Images were converted to a 3D surface mesh file for fabrication using a multi-jet 3D printer. A novel construction technique was employed to approximate normal renal tissue texture, printers selectively deposited photopolymer material forming the outer shell of the kidney, and subsequently, an agarose gel solution was injected into the inner cavity recreating the spongier renal parenchyma...
January 20, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28108958/biocompatibility-study-of-three-distinct-carbon-pastes-for-application-as-electrode-material-in-neural-stimulations-and-recordings
#19
Melinda Varga, Paul Wolff, Klaus-Juergen Wolter
Neural interfaces hold great promise for research and treatment of a wide variety of neurological diseases. Medical electrodes are designed to interface with the nervous system and provide control signals for neural prostheses. We fabricated previously a hook-up neural electrode. Here we investigate the in vitro cytotoxicity of three commercial carbon pastes used for printing the conductor tracks of this electrode. At first, the carbon pastes were characterized with respect to their microstructure and chemical composition...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28108955/-unforgettable-a-pictorial-essay-on-anatomy-and-pathology-of-the-hippocampus
#20
REVIEW
Sven Dekeyzer, Isabelle De Kock, Omid Nikoubashman, Stephanie Vanden Bossche, Ruth Van Eetvelde, Jeroen De Groote, Marjan Acou, Martin Wiesmann, Karel Deblaere, Eric Achten
: The hippocampus is a small but complex anatomical structure that plays an important role in spatial and episodic memory. The hippocampus can be affected by a wide range of congenital variants and degenerative, inflammatory, vascular, tumoral and toxic-metabolic pathologies. Magnetic resonance imaging is the preferred imaging technique for evaluating the hippocampus. The main indications requiring tailored imaging sequences of the hippocampus are medically refractory epilepsy and dementia...
January 20, 2017: Insights Into Imaging
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