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https://www.readbyqxmd.com/read/27936472/relaxant-effect-of-sodium-tanshinone-iia-sulphonate-on-mouse-tracheal-smooth-muscle
#1
Yi-Lin Zhang, Jia-Wen Xu, Xiong-Hao Wu, Peng-Xiao Chen, Fang Wei, Dong-Dong Gao, Xiao-Wen Chen, Yu-Li Luo, Yun-Xin Zhu, Jiehong Huang, Ya-Xia Tan, Lei Zhao, Wen-Liang Zhou
Sodium tanshinone IIA sulphonate, a water-soluble derivative of tanshinone IIA, has been proven to possess versatile biological properties, but its pharmacological effect on tracheal smooth muscle remains elusive. This paper presents a study on the relaxant effect and underlying mechanisms of sodium tanshinone IIA sulphonate on mouse tracheal smooth muscle. The relaxant effect of sodium tanshinone IIA sulphonate was evaluated in mouse tracheal rings using a mechanical recording system. Intracellular Ca(2+) concentration was measured in primary cultured tracheal smooth muscle cells using confocal imaging system...
December 9, 2016: Planta Medica
https://www.readbyqxmd.com/read/27936454/white-matter-volumes-in-youth-offspring-of-bipolar-parents
#2
Fabiano G Nery, Matthew Norris, James C Eliassen, Wade A Weber, Thomas J Blom, Jeffrey A Welge, Drew A Barzman, Jeffrey R Strawn, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello
BACKGROUND: Studying youth at high risk of developing bipolar disorder may clarify neurobiological factors associated with vulnerability to this illness. We present here a baseline characterization of brain structure in youth at-risk for bipolar disorder. METHODS: Magnetic resonance images were obtained from 115 child and adolescent offspring of bipolar disorder type I subjects and 57 healthy child and adolescent offspring of healthy parents (healthy control offspring)...
November 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936420/myofibroblastoma-of-the-male-breast-a-rare-entity-with-radiologic-pathologic-correlation
#3
John D Comer, Xiaoyan Cui, Carolyn Sharyn Eisen, Genevieve Abbey, Elizabeth Kagan Arleo
A 73-year old man with a history of multiple genitourinary malignancies was found to have a left retroareolar soft tissue mass on CT assessment of disease, and dedicated breast imaging was recommended. Diagnostic mammography and ultrasonography confirmed a solid mass, for which biopsy was recommended. Pathologic analysis demonstrated a spindle cell neoplasm with an immunoreactivity pattern consistent with myofibroblastoma. While this entity is benign, nonspecific imaging features necessitate tissue sampling for pathologic diagnosis, and, given pathologic rarity, open communication between the radiologist and pathologist is important to establish the correct diagnosis and to recommend appropriate management...
November 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27936417/mesoporous-silica-based-versatile-theranostic-nanoplatform-constructed-by-layer-by-layer-assembly-for-excellent-photodynamic-chemo-therapy
#4
Wei-Hai Chen, Guo-Feng Luo, Wen-Xiu Qiu, Qi Lei, Li-Han Liu, Shi-Bo Wang, Xian-Zheng Zhang
Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd(3+)) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd(3+)...
December 1, 2016: Biomaterials
https://www.readbyqxmd.com/read/27936413/interactive-registration-between-supine-and-prone-scans-in-computed-tomography-colonography-using-band-height-images
#5
Youngchan Song, Hyunna Lee, Ho Chul Kang, Juneseuk Shin, Gil-Sun Hong, Seong Ho Park, Jeongjin Lee, Yeong-Gil Shin
In computed tomographic colonography (CTC), a patient is commonly scanned twice including supine and prone scans to improve the sensitivity of polyp detection. Typically, a radiologist must manually match the corresponding areas in the supine and prone CT scans, which is a difficult and time-consuming task, even for experienced scan readers. In this paper, we propose a method of supine-prone registration utilizing band-height images, which are directly constructed from the CT scans using a ray-casting algorithm containing neighboring shape information...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27936410/body-image-and-emotional-distress-in-newly-diagnosed-cancer-patients-the-mediating-role-of-dysfunctional-attitudes-and-rumination
#6
Jianlin Liu, Chao Xu Peh, Rathi Mahendran
Body image concerns (BIC) has been reported to be associated with emotional distress for cancers across various sites. This study sought to examine two cognitive vulnerability mechanisms: dysfunctional attitudes and rumination, and their combined effects on the relationship between BIC and emotional distress in newly diagnosed Asian cancer patients. Participants were 221 newly diagnosed adult cancer patients who were assessed on BIC, rumination, dysfunctional attitudes, and emotional distress. Path analysis was used to examine the hypothesized mediation model...
December 6, 2016: Body Image
https://www.readbyqxmd.com/read/27936385/interrater-reliability-in-pediatric-urodynamic-tracings-a-pilot-study
#7
Anne G Dudley, Daniel P Casella, Chelsea J Lauderdale, Shilin Zhao, Heidi Chen, Stacy T Tanaka, John C Thomas, John C Pope, Mark C Adams, John W Brock, Chevis N Shannon, Douglass B Clayton
PURPOSE: Urodynamic studies are crucial to neuropathic bladder management and they often determine surgical intervention. However, current evidence indicates that interpretations show poor agreement across physicians. We sought to determine the interrater reliability of urodynamic interpretation in our practice. We hypothesized that there would be strong correlation among pediatric urologists of similar training in a single academic practice. MATERIALS AND METHODS: We retrospectively identified patients with neuropathic bladder who underwent urodynamics at our institution between 2014 and 2015...
December 6, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27936369/the-association-between-body-image-and-behavioral-misperception-bibm-and-alcohol-use-among-high-school-girls-results-from-the-2013-youth-risk-behavioral-survey
#8
Anna C Schlissel, Taylort T Schwartz, Margie R Skeer
OBJECTIVE: The need to be thin is pervasive in adolescent culture and is associated with increased risk outcomes among adolescent girls. Body image and behavioral misperception (BIBM) exists when there is a disconnect between body weight perception and actions taken related to perceived weight status. To understand this further, we examined the relationship between BIBM and alcohol use among high school girls in the United States. METHOD: Using 2013 Youth Risk Behavior Survey data, we ran survey-weighted multivariable logistic regression analyses to examine BIBM and (a) lifetime alcohol use, (b) current alcohol use, and (c) current heavy episodic drinking (≥5 drinks in a few hours) among female high school students (N = 6,579)...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936275/what-is-learned-when-learning-to-point-at-invisible-targets
#9
Derek H Arnold, Vivien Yuen
Binocular masking is a particularly interesting means of suppressing human visual awareness, as images rendered subjectively "invisible" via binocular masking nonetheless excite robust activity in human visual cortex. Recently, binocular masking has been leveraged to show that people can be trained to better interact with inputs that, subjectively, remain invisible. Here we ask what is learned in such circumstances. Do people become more adept at using weak encoded signals to guide hand movements, or is signal encoding enhanced, resulting in heightened objective sensitivity? To assess these possibilities, we had people train on five consecutive days, to reach toward and point at a target presented in one of three masked locations...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936272/uncertainty-of-sensory-signal-explains-variation-of-color-constancy
#10
Christoph Witzel, Carlijn van Alphen, Christoph Godau, J Kevin O'Regan
Color constancy is the ability to recognize the color of an object (or more generally of a surface) under different illuminations. Without color constancy, surface color as a perceptual attribute would not be meaningful in the visual environment, where illumination changes all the time. Nevertheless, it is not obvious how color constancy is possible in the light of metamer mismatching. Surfaces that produce exactly the same sensory color signal under one illumination (metamerism) may produce utterly different sensory signals under another illumination (metamer mismatching)...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936271/multiple-stage-ambiguity-in-motion-perception-reveals-global-computation-of-local-motion-directions
#11
Andrew T Rider, Shin'ya Nishida, Alan Johnston
The motion of a 1D image feature, such as a line, seen through a small aperture, or the small receptive field of a neural motion sensor, is underconstrained, and it is not possible to derive the true motion direction from a single local measurement. This is referred to as the aperture problem. How the visual system solves the aperture problem is a fundamental question in visual motion research. In the estimation of motion vectors through integration of ambiguous local motion measurements at different positions, conventional theories assume that the object motion is a rigid translation, with motion signals sharing a common motion vector within the spatial region over which the aperture problem is solved...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27936268/fast-spectral-surface-plasmon-resonance-imaging-sensor-for-real-time-high-throughput-detection-of-biomolecular-interactions
#12
Kaiqiang Chen, Youjun Zeng, Lei Wang, Dayong Gu, Jianan He, Shu-Yuen Wu, Ho-Pui Ho, Xuejin Li, Junle Qu, Bruce Zhi Gao, Yonghong Shao
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27936264/4d-graph-based-segmentation-for-reproducible-and-sensitive-choroid-quantification-from-longitudinal-oct-scans
#13
Ipek Oguz, Michael D Abramoff, Li Zhang, Kyungmoo Lee, Ellen Ziyi Zhang, Milan Sonka
Purpose: Longitudinal imaging is becoming more commonplace for studies of disease progression, response to treatment, and healthy maturation. Accurate and reproducible quantification methods are desirable to fully mine the wealth of data in such datasets. However, most current retinal OCT segmentation methods are cross-sectional and fail to leverage the inherent context present in longitudinal sequences of images. Methods: We propose a novel graph-based method for segmentation of multiple three-dimensional (3D) scans over time (termed 3D + time or 4D)...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27936246/diagnostic-accuracy-of-clinical-examination-and-imaging-findings-for-identifying-subacromial-pain
#14
Angela Cadogan, Peter J McNair, Mark Laslett, Wayne A Hing
BACKGROUND: The diagnosis of subacromial pathology is limited by the poor accuracy of clinical tests for specific pathologies. The aim of this study was to estimate the diagnostic accuracy of clinical examination and imaging features for identifying subacromial pain (SAP) defined by a positive response to diagnostic injection, and to evaluate the influence of imaging findings on the clinical diagnosis of SAP. METHODS AND FINDINGS: In a prospective, diagnostic accuracy design, 208 consecutive patients presenting to their primary healthcare practitioner for the first time with a new episode of shoulder pain were recruited...
2016: PloS One
https://www.readbyqxmd.com/read/27936213/radiologic-histopathologic-correlation-of-cerebral-microbleeds-using-pre-mortem-and-post-mortem-mri
#15
Sven Haller, Marie-Louise Montandon, François Lazeyras, Max Scheffler, Stephan Meckel, Francois R Herrmann, Panteleimon Giannakopoulos, Enikö Kövari
INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation...
2016: PloS One
https://www.readbyqxmd.com/read/27936206/abdominal-adiposity-not-cardiorespiratory-fitness-mediates-the-exercise-induced-change-in-insulin-sensitivity-in-older-adults
#16
Gifferd Ko, Lance E Davidson, Andrea M Brennan, Miu Lam, Robert Ross
Abdominal obesity and low cardiorespiratory fitness (CRF) are associated with insulin resistance in older adults. Exercise is associated with improvement in insulin sensitivity. Whether this association is mediated by change in CRF and/or abdominal obesity is unclear. The current study is a secondary analysis of data from a randomized controlled trial in Kingston, Ontario. Sedentary older adults (60-80 years) (N = 80) who completed the exercise (N = 59) or control (N = 21) conditions for 6 months were included...
2016: PloS One
https://www.readbyqxmd.com/read/27936162/discovery-of-a-novel-isothiazolonaphthoquinone-based-small-molecule-activator-of-foxo-nuclear-cytoplasmic-shuttling
#17
Bastien Cautain, Francisco Castillo, Loana Musso, Bibiana I Ferreira, Nuria de Pedro, Lorena Rodriguez Quesada, Susana Machado, Francisca Vicente, Sabrina Dallavalle, Wolfgang Link
FOXO factors are tumour suppressor proteins commonly inactivated in human tumours by posttranslational modifications. Furthermore, genetic variation within the FOXO3a gene is consistently associated with human longevity. Therefore, the pharmacological activation of FOXO proteins is considered as an attractive therapeutic approach to treat cancer and age-related diseases. In order to identify agents capable of activating FOXOs, we tested a collection of small chemical compounds using image-based high content screening technology...
2016: PloS One
https://www.readbyqxmd.com/read/27936122/association-of-odor-thresholds-and-responses-in-cerebral-blood-flow-of-the-prefrontal-area-during-olfactory-stimulation-in-patients-with-multiple-chemical-sensitivity
#18
Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Bamba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe
Multiple chemical sensitivity (MCS) is a disorder characterized by nonspecific and recurrent symptoms from various organ systems associated with exposure to low levels of chemicals. Patients with MCS process odors differently than controls do. Previously, we suggested that this odor processing was associated with increased regional cerebral blood flow (rCBF) in the prefrontal area during olfactory stimulation using near-infrared spectroscopic (NIRS) imaging. The aim of this study was to investigate the association of odor thresholds and changes in rCBF during olfactory stimulation at odor threshold levels in patients with MCS...
2016: PloS One
https://www.readbyqxmd.com/read/27936106/feasibility-of-10-minute-delayed-hepatocyte-phase-imaging-using-a-30%C3%A2-flip-angle-in-gd-eob-dtpa-enhanced-liver-mri-for-the-detection-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-or-cirrhosis
#19
Inhwan Jeon, Eun-Suk Cho, Joo Hee Kim, Dae Jung Kim, Jeong-Sik Yu, Jae-Joon Chung
OBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27936069/multimodal-imaging-of-photoreceptor-structure-in-choroideremia
#20
Lynn W Sun, Ryan D Johnson, Vesper Williams, Phyllis Summerfelt, Alfredo Dubra, David V Weinberg, Kimberly E Stepien, Gerald A Fishman, Joseph Carroll
PURPOSE: Choroideremia is a progressive X-linked recessive dystrophy, characterized by degeneration of the retinal pigment epithelium (RPE), choroid, choriocapillaris, and photoreceptors. We examined photoreceptor structure in a series of subjects with choroideremia with particular attention to areas bordering atrophic lesions. METHODS: Twelve males with clinically-diagnosed choroideremia and confirmed hemizygous mutations in the CHM gene were examined. High-resolution images of the retina were obtained using spectral domain optical coherence tomography (SD-OCT) and both confocal and non-confocal split-detector adaptive optics scanning light ophthalmoscope (AOSLO) techniques...
2016: PloS One
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