keyword
MENU ▼
Read by QxMD icon Read
search

intestinal metaplasia stomach

keyword
https://www.readbyqxmd.com/read/28455161/outcomes-of-screening-gastroscopy-in-first-degree-relatives-of-patients-fulfilling-hereditary-diffuse-gastric-cancer-criteria
#1
Rachel S van der Post, Jolanda van Dieren, Anna Grelack, Nicoline Hoogerbrugge, Lizet E van der Kolk, Petur Snaebjornsson, Iris Lansdorp-Vogelaar, J Han van Krieken, Tanya M Bisseling, Annemieke Cats
BACKGROUND AND AIMS: The aim of this study was to determine the yield of endoscopic screening in first-degree relatives (FDR) of CDH1-negative hereditary diffuse gastric cancer (HDGC) patients. METHODS: Retrospective observational cohort study. In 2 expert centers in the Netherlands data were collected on FDR from families fulfilling the international HDGC criteria that underwent endoscopic screening. Extensive inspection of the stomach was performed by gastroscopy, taking random and/or targeted stomach biopsy specimens to identify diffuse-type gastric cancer...
April 25, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28451845/reflux-esophagitis-and-its-role-in-the-pathogenesis-of-barrett-s-metaplasia
#2
REVIEW
Rhonda Frances Souza
Reflux esophagitis damages the squamous epithelium that normally lines the esophagus, and promotes replacement of the damaged squamous lining by the intestinal metaplasia of Barrett's esophagus, the precursor of esophageal adenocarcinoma. Therefore, to prevent the development of Barrett's metaplasia and esophageal adenocarcinoma, the pathogenesis of reflux esophagitis must be understood. We have reported that reflux esophagitis, both in a rat model and in humans, develops as a cytokine-mediated inflammatory injury (i...
April 27, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28395383/extending-magnifying-nbi-diagnosis-of-intestinal-metaplasia-in-the-stomach-the-white-opaque-substance-marker
#3
Takao Kanemitsu, Kenshi Yao, Takashi Nagahama, Kentaro Imamura, Shoko Fujiwara, Toshiharu Ueki, Kenta Chuman, Hiroshi Tanabe, Ota Atsuko, Akinori Iwashita, Toshio Shimokawa, Kunihisa Uchita, Takashi Kanesaka
Light-blue crests and white opaque substance are two features of intestinal metaplasia in the stomach that can be observed with magnifying narrow-band imaging. In a prospective pilot trial, Kanemitsu et al. show that combining these two findings significantly improves the sensitivity for detecting intestinal metaplasia. Background and aims Intestinal metaplasia (IM) of the stomach is associated with an increased risk of differentiated gastric cancer. While it is important to diagnose IM endoscopically, it can be difficult to observe by white-light endoscopy...
April 10, 2017: Endoscopy
https://www.readbyqxmd.com/read/28322295/alterations-in-gastric-microbiota-after-h-pylori-eradication-and-in-different-histological-stages-of-gastric-carcinogenesis
#4
Tung Hiu Li, Youwen Qin, Pak Chung Sham, K S Lau, Kent-Man Chu, Wai K Leung
The role of bacteria other than Helicobacter pylori (HP) in the stomach remains elusive. We characterized the gastric microbiota in individuals with different histological stages of gastric carcinogenesis and after receiving HP eradication therapy. Endoscopic gastric biopsies were obtained from subjects with HP gastritis, gastric intestinal metaplasia (IM), gastric cancer (GC) and HP negative controls. Gastric microbiota was characterized by Illumina MiSeq platform targeting the 16 S rDNA. Apart from dominant H...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275687/hedgehog-signaling-links-chronic-inflammation-to-gastric-cancer-precursor-lesions
#5
REVIEW
Juanita L Merchant, Lin Ding
Since its initial discovery in Drosophila, Hedgehog (HH) signaling has long been associated with foregut development. The mammalian genome expresses 3 HH ligands, with sonic hedgehog (SHH) levels highest in the mucosa of the embryonic foregut. More recently, interest in the pathway has shifted to improving our understanding of its role in gastrointestinal cancers. The use of reporter mice proved instrumental in our ability to probe the expression pattern of SHH ligand and the cell types responding to canonical HH signaling during homeostasis, inflammation, and neoplastic transformation...
March 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28260713/a-case-of-gastric-type-adenoma-with-chief-cell-and-parietal-cell-differentiation-surrounded-by-complete-intestinal-metaplasia
#6
Ryutaro Furukawa, Tsuneo Oyama, Akiko Takahashi, Nobukazu Yorimitsu, Tadakazu Shimoda, Hiroyoshi Ota, Satoshi Shiozawa
A man in his 70s received Helicobacter pylori eradication therapy after endoscopic submucosal dissection (ESD) of the stomach. A small, yellowish, protuberant lesion was later observed on the anterior wall of the lower body of the stomach on surveillance esophagogastroduodenoscopy. Narrow band imaging-magnified endoscopy showed an irregular pit and net-like vascular pattern, with the background mucosa having a light blue crest pattern. A biopsy was performed, which led to a diagnosis of adenoma with a gastric phenotype, so repeat ESD was performed...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28229187/-precursors-of-gastric-cancer-dysplasia-and-adenoma
#7
C Langner
Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines...
February 22, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28206938/a-review-of-sleeve-gastrectomy-specimen-histopathology
#8
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28206729/gut-microbiota-and-gastric-disease
#9
Dolores Sgambato, Agnese Miranda, Lorenzo Romano, Marco Romano
The gut microbiota may be considered a crucial "organ" of human body because of its role in the maintenance of the balance between health as well as disease. It is mainly located in the small bowel and colon, while, the stomach was long thought to be sterile in particular for its high acid production. In particular, stomach was considered "an hostile place" for bacterial growth until the identification of Helicobacter pylori (HP). Now, the stomach and its microbiota can be considered as two different "organs" that share the same place and they have an impact on each other...
February 15, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28174755/murine-models-of-gastric-corpus-preneoplasia
#10
REVIEW
Christine P Petersen, Jason C Mills, James R Goldenring
Intestinal-type gastric adenocarcinoma evolves in a field of pre-existing metaplasia. Over the past 20 years, a number of murine models have been developed to address aspects of the physiology and pathophysiology of metaplasia induction. Although none of these models has achieved true recapitulation of the induction of adenocarcinoma, they have led to important insights into the factors that influence the induction and progression of metaplasia. Here, we review the pathologic definitions relevant to alterations in gastric corpus lineages and classification of metaplasia by specific lineage markers...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28135297/acetic-acid-enhanced-narrow-band-imaging-for-the-diagnosis-of-gastric-intestinal-metaplasia
#11
Jie Sha, Pin Wang, Bingliang Zhu, Minghui Zhu, Xueliang Li, Feng Gao
Gastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach. The detection of GIM using conventional white-light endoscopy (WLE) is difficult. In this study, we determined whether acetic acid-enhanced narrow band imaging (AA-NBI) improves the detection of GIM. A consecutive cohort of 132 individuals aged 40 years or older was subjected to upper gastrointestinal endoscopy using WLE, NBI and AA-NBI. The ability of the three methods to diagnose GIM in patients was compared. Histological assessment (per-patient and per-biopsy) was used for the accuracy assessment...
2017: PloS One
https://www.readbyqxmd.com/read/28124157/impact-of-the-microbiota-and-gastric-disease-development-by-helicobacter-pylori
#12
Teresa Alarcón, Laura Llorca, Guillermo Perez-Perez
Microorganisms in humans form complex communities with important functions and differences in each part of the body. The stomach was considered to be a sterile organ until the discovery of Helicobacter pylori, but nowadays, it is possible to demonstrate that other microorganisms beyond H. pylori can colonize the gastric mucosa and that the diverse microbiota ecosystem of the stomach is different from the mouth and the esophagus, and also from the small intestine and large intestine. H. pylori seems to be the most important member of the gastric microbiota with the highest relative abundance when present, but when it is absent, the stomach has a diverse microbiota...
2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28053963/expression-of-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd44-potential-implications-for-gastric-cancer-stem-cell-marker
#13
Yoon Jin Choi, Nayoung Kim, Hye Seung Lee, Seon Mee Park, Ji Hyun Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The human leucine-rich repeat-containing G-protein coupled receptor (LGR) 5 and CD44 are one of the candidates for the marker of gastric cancer stem cells. We compared the expressions of two genes among control, dysplasia and cancer groups. METHODS: We compared the mRNA expression of LGR5, CD44 and CD44v8-10 and immunohistochemistry (IHC) of LGR5 and CD44 in gastric antral mucosa of 45 controls, 36 patients with gastric dysplasia, and 39 patients with early gastric cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28003849/conifer-green-needle-complex-in-patients-with-precancerous-gastric-lesions-an-observational-pilot-study
#14
Vladimir Bespalov, Alexander Sherbakov, Viktor Novik, Valentin Kalinovsky, Kamran Shamsi, Vagif Soultanov
Objectives. Helicobacter pylori infection is common and can lead to precancerous gastric lesions. Standard antibiotic therapy has a failure rate of more than 25% from antibiotic resistance. The primary aim of this observational pilot study was to test the feasibility of a large-scale clinical trial of Conifer Green Needle Complex (CGNC) to treat precancerous gastric lesions. Secondary aims were to investigate H. pylori infection, stomach function, and histopathology of the gastric mucosa. Methods. A tablet form of CGNC (extracted from Pinus sylvestris and Picea abies (L) Karst) was prescribed to 26 patients with precancerous gastric lesions (two tablets, 100 mg CGNC/tablet, three times per day for six months)...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27771376/clinicopathological-characteristics-of-invasive-gastric-helicobacter-pylori
#15
Jonathan Dudley, Tad Wieczorek, Martin Selig, Hoiwan Cheung, Jeanne Shen, Robert Odze, Vikram Deshpande, Lawrence Zukerberg
Helicobacter pylori organisms have been observed deep within the stomach mucosa with an "intracellular" appearance, although the clinicopathological characteristics of such cases remain poorly understood. We analyzed 18 cases of deep mucosal H pylori and associated clinical (sex, age, history of H pylori infection, or proton pump inhibitor [PPI] use, medications, smoking, alcohol use, comorbidities, treatment response) and pathological (presence of lymphoid aggregates, intestinal metaplasia, PPI effect, active and/or chronic inflammation, quantity of invasive versus surface H pylori) characteristics...
March 2017: Human Pathology
https://www.readbyqxmd.com/read/27738541/metastatic-gastrointestinal-adenocarcinoma-with-osteoblastic-activity-a-case-report-of-esophageal-and-colonic-primaries
#16
Brett Matthew Lowenthal, Ahmed S Shabaik, Mark A Valasek
Adenocarcinoma with osteoblastic metastases is classically seen in prostate, breast, and lung primaries. Less common primary sites include thyroid, kidney, and stomach. We present two cases of primary gastrointestinal adenocarcinoma with metastatic osteoblastic activity from two previously unreported sites. The first case represents an esophageal adenocarcinoma arising in a background of intestinal metaplasia that metastasized with osteoblastic activity to the deltoid muscle. The second case demonstrates a Stage IV sigmoid colon adenocarcinoma with osteoblastic metastases to the liver and lymph nodes...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27729732/impact-of-homeobox-genes-in-gastrointestinal-cancer
#17
REVIEW
Moon Kyung Joo, Jong-Jae Park, Hoon Jai Chun
Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal (GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1 (CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett's esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27609464/loss-of-mesenchymal-bone-morphogenetic-protein-signaling-leads-to-development-of-reactive-stroma-and-initiation-of-the-gastric-neoplastic-cascade
#18
Sébastien A B Roy, Joannie M Allaire, Camille Ouellet, Faiza Maloum-Rami, Véronique Pomerleau, Étienne Lemieux, Jean-Philippe Babeu, Jasmin Rousseau, Marilène Paquet, Perrine Garde-Granger, François Boudreau, Nathalie Perreault
Bmps are morphogens involved in various gastric cellular functions. Studies in genetically-modified mice have shown that Bmp disruption in gastric epithelial and stromal cell compartments leads to the development of tumorigenesis. Our studies have demonstrated that abrogation of gastric epithelial Bmp signaling alone was not sufficient to recapitulate the neoplastic features associated with total gastric loss of Bmp signaling. Thus, epithelial Bmp signaling does not appear to be a key player in gastric tumorigenesis initiation...
September 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27604361/gastric-microbiota-and-carcinogenesis-the-role-of-non-helicobacter-pylori-bacteria-a-systematic-review
#19
Emanuel Dias-Jácome, Diogo Libânio, Marta Borges-Canha, Ana Galaghar, Pedro Pimentel-Nunes
BACKGROUND AND AIM: Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis. METHODS: A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed...
September 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27573783/helicobacter-pylori-and-gastric-cancer-timing-and-impact-of-preventive-measures
#20
REVIEW
Marino Venerito, Riccardo Vasapolli, Peter Malfertheiner
Helicobacter pylori (H. pylori) is a Gram negative spiraliform bacterium that is commonly found in the stomach. H. pylori infection is still one of the world's most frequent infections, present in the stomachs of approximately one-half of the world's people. H. pylori infection is etiologically linked to histologic chronic active gastritis, peptic ulcer disease, and primary B-cell gastric lymphoma (gastric MALT lymphoma) and represents the major risk factor for the development of sporadic non-cardia gastric cancer (GC) of both intestinal and diffuse type...
2016: Advances in Experimental Medicine and Biology
keyword
keyword
37178
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"