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https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#1
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade PC. It's possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of PC. Pioglitazone, a ligand of PPARγ is used to treat diabetes and possesses anti-inflammatory properties...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29221142/d-4f-increases-microrna-124a-and-reduces-neuroinflammation-in-diabetic-stroke-rats
#2
Ruizhuo Ning, Poornima Venkat, Michael Chopp, Alex Zacharek, Tao Yan, Xu Cui, Don Seyfried, Jieli Chen
D-4F is an apolipoprotein-A1 mimetic peptide that promotes anti-inflammatory effects. MicroRNA-124 is the most abundant brain-specific microRNA and has anti-inflammatory effects. In this study, we investigated the therapeutic efficacy and mechanisms of D-4F treatment of stroke in type one diabetes mellitus (T1DM) rats. Male Wistar rats were induced with T1DM, subjected to embolic middle cerebral artery occlusion and treated with PBS or D-4F (1 mg/kg i.p.) at 2, 24 and 48 hours after stroke (n=8/group). A battery of function tests, brain blood barrier (BBB) integrity, white matter changes and microRNA expression were evaluated in vivo and in vitro...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215791/protective-effects-of-carbonyl-iron-against-multiple-low-dose-streptozotocin-induced-diabetes-in-rodents
#3
Milica Vujicic, Tamara Saksida, Marija Mostarica Stojkovic, Neda Djedovic, Ivana Stojanovic, Stanislava Stosic-Grujicic
Particulate adjuvants have shown increasing promise as effective, safe and durable agents for the stimulation of immunity, or alternatively, the suppression of autoimmunity. Here we examined the potential of the adjuvant carbonyl iron (CI) for the modulation of organ-specific autoimmune disease - type 1 diabetes (T1D). T1D was induced by multiple low doses of streptozotocin (MLDS) that initiates beta cell death and triggers immune cell infiltration into the pancreatic islets. The results of this study indicate that the single in vivo application of CI to MLDS-treated DA rats, CBA/H mice, or C57BL/6 mice successfully counteracted the development of insulitis and hyperglycemia...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29213335/liraglutide-attenuates-atherosclerosis-via-inhibiting-er-induced-macrophage-derived-microvesicles-production-in-t2dm-rats
#4
Jinjin Li, Xiaojuan Liu, Qianhua Fang, Min Ding, Chunjun Li
Background: We investigated the effects of liraglutide on the formation and progression of atherosclerosis in type 2 diabetes mellitus (T2DM) rats. Methods: Sprague-Dawley rats were divided into control group, diabetes group and liraglutide treated group. The T2DM rats model with atherosclerosis were induced by high fat diet followed small dosage streptozotocin injection. Body weight and blood glucose levels were monitored once a week for 3 months and then the rats were sacrificed...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29212268/comp-angiopoietin-1-mitigates-changes-in-lipid-droplet-size-macrophage-infiltration-of-adipose-tissue-and-renal-inflammation-in-streptozotocin-induced-diabetic-mice
#5
Yu Jin Jung, Woong Park, Tung Nguyen-Thanh, Kyung Pyo Kang, Heung Young Jin, Suhn Hee Kim, Wonhee Suh, Won Kim
Adipose tissue is considered to be an endocrine organ, and adipocyte size correlates with insulin resistance and metabolic parameters in obesity. There is little data on the effects of angiopoietin-1 in adipose tissue and kidney in streptozotocin (STZ)-induced diabetes. In this study, we investigated the protective effect of COMP-angiopoietin-1 (COMP-Ang1), a potent variant of angiopoietin-1, on vascular endothelial cells in epididymal adipose tissue and its regulatory effect on other metabolic parameters, such as lipid droplet diameter, macrophage infiltration, and renal inflammation in STZ-treated mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208701/interleukin-23-regulates-interleukin-17-expression-in-wounds-and-its-inhibition-accelerates-diabetic-wound-healing-through-the-alteration-of-macrophage-polarization
#6
James Lee, Mathieu Paul Rodero, Jatin Patel, Davide Moi, Roberta Mazzieri, Kiarash Khosrotehrani
Inflammation is a critical phase in the healing of skin wounds. Excessive inflammation and inflammatory macrophages are known to cause impaired wound closure and outcome. This prompted us to test the role of IL-23 in IL-17 expression and in modulating wound inflammation and macrophage polarization. Full-thickness wounds (4 × 6 mm) were created on the dorsal surface of multiple genetically modified mouse models. Obese diabetic mouse wounds were treated with anti-IL-17A, anti-IL-23, or isotype-matched antibodies...
December 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29195137/the-nadph-organizers-noxo1-and-p47phox-are-both-mediators-of-diabetes-induced-vascular-dysfunction-in-mice
#7
Flávia Rezende, Franziska Moll, Maria Walter, Valeska Helfinger, Fabian Hahner, Patrick Janetzko, Christian Ringel, Andreas Weigert, Ingrid Fleming, Norbert Weissmann, Carsten Kuenne, Mario Looso, Michael A Rieger, Peter Nawroth, Thomas Fleming, Ralf P Brandes, Katrin Schröder
AIM: NADPH oxidases are important sources of reactive oxygen species (ROS). Several Nox homologues are present together in the vascular system but whether they exhibit crosstalk at the activity level is unknown. To address this, vessel function of knockout mice for the cytosolic Nox organizer proteins p47phox, NoxO1 and a p47phox-NoxO1-double knockout were studied under normal condition and during streptozotocin-induced diabetes. RESULTS: In the mouse aorta, mRNA expression for NoxO1 was predominant in smooth muscle and endothelial cells, whereas p47phox was markedly expressed in adventitial cells comprising leukocytes and tissue resident macrophages...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29190959/effect-of-ampk-signal-pathway-on-pathogenesis-of-abdominal-aortic-aneurysms
#8
Le Yang, Lin Shen, Peixian Gao, Gang Li, Yuxiang He, Maohua Wang, Hua Zhou, Hai Yuan, Xing Jin, Xuejun Wu
Background and aims: Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm). Methods: AAA was induced in ApoE-/- mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely used anti-diabetic drug which could activate AMPK signal pathway, on the pathogenesis of aneurysm...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29184392/paeoniflorin-attenuates-incipient-diabetic-nephropathy-in-streptozotocin-induced-mice-by-the-suppression-of-the-toll-like-receptor-2-signaling-pathway
#9
Yun-Xia Shao, Xing-Xin Xu, Kun Wang, Xiang-Ming Qi, Yong-Gui Wu
Toll-like receptors (TLRs) may be involved in diabetic nephropathy (DN). Paeoniflorin (PF) is an effective Chinese traditional medicine with anti-inflammatory and immunoregulatory effects that may inhibit the TLR2 signaling pathway. In this study, we investigated the effects of PF on the kidneys of mice with streptozotocin-induced type 1 diabetes mellitus using TLR2 knockout mice (TLR2-/-) and wild-type littermates (C57BL/6J-WT). After 12 weeks of intraperitoneal injection of PF at doses of 25, 50, and 100 mg/kg once a day, diabetic mice had significantly reduced albuminuria and attenuated renal histopathology...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29179278/-expression-of-macrophage-migration-inhibitory-factor-gene-in-placenta-tissue-and-its-correlation-with-gestational-diabetes-mellitus
#10
L Zheng, C Li, W H Qi, B L Qiao, H Zhao, Y B Zhou, C X Lu
Objective: To investigate the relationship between the expression of macrophage migration inhibitory factor (MIF) gene and the incidence of gestational diabetes mellitus (GDM) in Chinese Han population in northern China. Method: This study was consisted of 126 GDM women and 150 cases of healthy subjects who came from the obstetrics department of Maternity Hospital of Qingdao University and Maternity and Child Care Hospital of Donggang District of Rizhao. The protein expression of MIF in placenta tissue was detected by Western blot method...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29177841/xanthogranulomatous-pyelonephritis-a-case-with-rare-adhesion-to-pancreas
#11
Tuba Devrim, Pınar Atasoy, Devrim Tuğlu
Xanthogranulomatous pyelonephritis (XGP) is a rare benign condition with unknown aetiology and chronic infection of kidney. Commonly, most cases are related with urinary tract obstruction, nephrolithiasis, infection, diabetes, and/or immune compromise. XGP is associated with destruction of the renal parenchyma and granulomatous inflammation with foamy lipid-laden macrophages resulting from obstructive uropathy. It closely mimics a malignancy, exhibiting local tissue invasion and destruction. Adjacent organs especially duodenum as well as very rarely pancreas or spleen may be involved...
November 25, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29176006/gpr120-mechanism-of-action-role-and-potential-for-medical-applications
#12
Hanna Karakuła-Juchnowicz, Joanna Róg, Dariusz Juchnowicz, Justyna Morylowska-Topolska
G protein-coupled receptors (GPCRs) constitute a family of transmembrane proteins that mediate many cellular processes. GPR120/FFAR4, a receptor from this family that is activated by fatty acids, has received considerable attention recently. This paper presents a literature review concerning the role of GPR120 and its mechanism of action in animal and human studies as well as the potential use of GPR120 for the treatment of chronic diseases. Two electronic databases - Medline and Google Scholar - were searched for available studies addressing the review topic that were written in English and published from 2000 to June 2017...
November 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29175142/flaxseed-oil-rich-in-omega-3-protects-aorta-against-inflammation-and-endoplasmic-reticulum-stress-partially-mediated-by-gpr120-receptor-in-obese-diabetic-and-dyslipidemic-mice-models
#13
Alexandre Moura-Assis, Milessa Silva Afonso, Vanessa de Oliveira, Joseane Morari, Gustavo Aparecido Dos Santos, Marcia Koike, Ana Maria Lottenberg, Rodrigo Ramos Catharino, Licio Augusto Velloso, Adelino Sanchez Ramos da Silva, L P de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli, Dennys Esper Corrêa Cintra
The "first hit" to atherogenesis is driven by toll-like receptor 4, endoplasmic reticulum stress and ultimately metabolic dysfunction. In this study, we hypothesized that a flaxseed oil-enriched diet (FS) abolishes these inflammatory signaling pathway and restore metabolic homeostasis by activating the fatty acid receptor GPR120 in aorta of obese mice. Glucose homeostasis was assessed by GTT and ITT; lipidomics was performed using a Hybrid Ion Trap-Orbitrap Mass Spectrometer; serum lipids were measured using colorimetric assays; GPR120 and infiltrating macrophages were analyzed by immunofluorescence; protein immunoprecipitation and gene expression were evaluated by Western blot and RT-PCR, respectively...
October 18, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29171836/crig-a-tissue-resident-macrophage-specific-immune-checkpoint-molecule-promotes-immunological-tolerance-in-nod-mice-via-a-dual-role-in-effector-and-regulatory-t-cells
#14
Xiaomei Yuan, Bi-Huei Yang, Yi Dong, Asami Yamamura, Wenxian Fu
How tissue-resident macrophages (TRM) impact adaptive immune responses remains poorly understood. We report a novel mechanism by which TRMs regulate T cell activities at tissue sites. This mechanism was mediated by the complement receptor of immunoglobulin family (CRIg). Using animal models for autoimmune type 1 diabetes (T1D), we found that CRIg+ TRMs form a protective barrier surrounding pancreatic islets. Genetic ablation of CRIg exacerbated islet inflammation and local T cell activation. CRIg exhibited a dual function of attenuating early T cell activation and promoting the differentiation of Foxp3+ regulatory (Treg) cells...
November 24, 2017: ELife
https://www.readbyqxmd.com/read/29170525/advanced-glycation-endproducts-link-inflammatory-cues-to-upregulation-of-galectin-1-in-diabetic-retinopathy
#15
Atsuhiro Kanda, Yoko Dong, Kousuke Noda, Wataru Saito, Susumu Ishida
Diabetic retinopathy (DR) is an inflammatory and progressive vaso-occlusive disease resulting in angiogenesis. Galectin-1 is a hypoxia-induced angiogenic factor associated with cancer and proliferative DR. Here we reveal a significant upregulation of galectin-1 in eyes of DR patients along with progression of clinical stages beginning from the pre-ischemic, inflammatory stage with diabetic macular edema, but not in eyes with non-diabetic retinal vascular occlusions. As for its regulatory mechanism unrelated to hypoxia but selective to DR, in vitro galectin-1/LGALS1 expression was shown to increase after application to Müller glial cells with interleukin (IL)-1β, which was induced in monocyte-derived macrophages and microglial cells via toll-like receptor (TLR) 4 signaling stimulated by advanced glycation endproducts (AGE)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166590/interleukin-33-activated-islet-resident-innate-lymphoid-cells-promote-insulin-secretion-through-myeloid-cell-retinoic-acid-production
#16
Elise Dalmas, Frank M Lehmann, Erez Dror, Stephan Wueest, Constanze Thienel, Marcela Borsigova, Marc Stawiski, Emmanuel Traunecker, Fabrizio C Lucchini, Dianne H Dapito, Sandra M Kallert, Bruno Guigas, Francois Pattou, Julie Kerr-Conte, Pierre Maechler, Jean-Philippe Girard, Daniel Konrad, Christian Wolfrum, Marianne Böni-Schnetzler, Daniela Finke, Marc Y Donath
Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retinoic acid (RA)-producing capacities in macrophages and dendritic cells via the secretion of IL-13 and colony-stimulating factor 2...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29163205/localization-and-interaction-between-kinin-b1-receptor-and-nadph-oxidase-in-the-vascular-system-of-diabetic-rats
#17
Youssef Haddad, Réjean Couture
Kinin B1 receptor (B1R) enhanced superoxide anion ([Formula: see text]) production in the vasculature of diabetic rats. This study investigates the induction and distribution of B1R in diabetic blood vessels and addresses the hypothesis that B1R is co-localized with NADPH oxidase (NOX1 and NOX2) and produces its activation via protein kinase C (PKC). Diabetes was induced in rats with streptozotocin (STZ 65 mg.kg(-1), i.p.). Two weeks later, the production of [Formula: see text] was measured in aorta rings in response to the B1R agonist (Sar[D-Phe(8)]-des-Arg(9)-BK, 20 μM) by the method of lucigenin-enhanced chemiluminescence...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162603/exogenous-insulin-infusion-can-decrease-atherosclerosis-in-diabetic-rodents-by-improving-lipids-inflammation-and-endothelial-function
#18
Kyoungmin Park, Qian Li, Net Daş Evcimen, Christian Rask-Madsen, Yasutaka Maeda, Ernesto Maddaloni, Hisashi Yokomizo, Takanori Shinjo, Ronald St-Louis, Jialin Fu, Daniel Gordin, Mogher Khamaisi, David Pober, Hillary Keenan, George L King
OBJECTIVE: The objective of this study is to evaluate whether exogenously induced hyperinsulinemia may increase the development of atherosclerosis. APPROACH AND RESULTS: Hyperinsulinemia, induced by exogenous insulin implantation in high-fat fed (60% fat HFD) apolipoprotein E-deficient mice (ApoE-/-) mice, exhibited insulin resistance, hyperglycemia, and hyperinsulinemia. Atherosclerosis was measured by the accumulation of fat, macrophage, and extracellular matrix in the aorta...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29159716/rotula-aquatica-lour-attenuates-secretion-of-proinflammatory-mediators-and-cytokines-in-lipopolysaccharide-induced-inflammatory-responses-in-murine-raw-264-7-macrophages
#19
A Vysakh, Prasad Gopika, Kuriakose Jayesh, Raj Karishma, M S Latha
Rotula aquatica belongs to the family Boraginaceae, and is reported to contain baunerol, steroids and alkaloids. In Ayurveda, R. aquatica has been used for the treatment of various diseases such as diabetes, treatment of piles, venereal disease, and cancer. The current study aims to investigate the anti-inflammatory effect of methanolic extract of R. aquatica (MERA) in RAW 264.7 cells. The cytotoxicity of MERA was analyzed by MTT assay. The total cyclooxygenase (COX) activity, 5-lipoxygenase (5-LOX) activity, myeloperoxidase activity, inducible nitric oxide synthase activity, nitrate level and reactive oxygen species production were studied in LPS-stimulated RAW 264...
November 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29158465/tonicity-responsive-enhancer-binding-protein-mediates-hyperglycemia-induced-inflammation-and-vascular-and-renal-injury
#20
Soo Youn Choi, Sun Woo Lim, Shabnam Salimi, Eun Jin Yoo, Whaseon Lee-Kwon, Hwan Hee Lee, Jun Ho Lee, Braxton D Mitchell, Satoru Sanada, Afshin Parsa, Hyug Moo Kwon
Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD, novel targets for treatment are sorely needed. We previously reported that increased activity of tonicity-responsive enhancer-binding protein (TonEBP) in monocytes was associated with early DN in humans. We now extend these findings by testing the hypotheses that TonEBP in macrophages promotes hyperglycemia-mediated proinflammatory activation and chronic renal inflammation leading to DN and CKD, and TonEBP genetic variability in humans is associated with inflammatory, renal, and vascular function-related phenotypes...
November 20, 2017: Journal of the American Society of Nephrology: JASN
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