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https://www.readbyqxmd.com/read/29748757/solid-phase-extraction-of-phospholipids-using-mesoporous-silica-nanoparticles-application-to-human-milk-samples
#1
Héctor Martínez Pérez-Cejuela, Isabel Ten-Doménech, Jamal El Haskouri, Pedro Amorós, Ernesto F Simó-Alfonso, José Manuel Herrero-Martínez
In this study, mesoporous silica materials (MSMs) with bimodal pore systems (namely, UVM-7), MCM-41 silica, and a commercial silica-based material were evaluated as solid-phase extraction (SPE) sorbents for the isolation of phospholipids (PLs) using phosphatidylcholine as a test compound. Morphological characterization (including TEM, surface, and size pore measurements) of these materials was carried out. The mechanism of interaction of the target analyte with the MSMs was also studied. With regard to the SPE process, several experimental parameters that affect the extraction performance (e...
May 11, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29746711/a-monte-carlo-simulation-approach-for-beta-lactam-dosing-in-critically-ill-patients-receiving-prolonged-intermittent-renal-replacement-therapy
#2
Soo Min Jang, Katherine N Gharibian, Susan J Lewis, William H Fissell, Ashita J Tolwani, Bruce A Mueller
Cefepime, ceftazidime, and piperacillin/tazobactam are commonly used beta-lactam antibiotics in the critical care setting. For critically ill patients receiving prolonged intermittent renal replacement therapy (PIRRT), limited pharmacokinetic data are available to inform clinicians on the dosing of these agents. Monte Carlo simulations (MCS) can be used to guide drug dosing when pharmacokinetic trials are not feasible. For each antibiotic, MCS using previously published pharmacokinetic data derived from critically ill patients was used to evaluate multiple dosing regimens in 4 different prolonged intermittent renal replacement therapy effluent rates and prolonged intermittent renal replacement therapy duration combinations (4 L/h × 10 hours or 5 L/h × 8 hours in hemodialysis and hemofiltration modes)...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29713307/fetal-neuroprotection-by-magnesium-sulfate-from-translational-research-to-clinical-application
#3
REVIEW
Clément Chollat, Loïc Sentilhes, Stéphane Marret
Despite improvements in perinatal care, preterm birth still occurs regularly and the associated brain injury and adverse neurological outcomes remain a persistent challenge. Antenatal magnesium sulfate administration is an intervention with demonstrated neuroprotective effects for preterm births before 32 weeks of gestation (WG). Owing to its biological properties, including its action as an N -methyl-d-aspartate receptor blocker and its anti-inflammatory effects, magnesium is a good candidate for neuroprotection...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29430102/comparative-evaluation-of-remineralizing-potential-of-fluoride-using-three-different-remineralizing-protocols-an-in-vitro-study
#4
Rahul Rao, Ashish Jain, Meenakshi Verma, Deepak Langade, Amol Patil
Background: Remineralization of noncavitated enamel is dependent on the bioavailability of calcium, phosphate, and hydroxyl ions in saliva. However, it is enhanced by the presence of fluoride. This study compared the remineralizing potential of three different topical fluoride agents. Materials and Methods: Fifteen extracted premolars were selected for the study. The crown of each tooth was longitudinally sectioned buccolingually and mesiodistally using a diamond disc so as to obtain sixty specimens which were embedded in acrylic molds...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29372439/antioxidant-activity-of-polyphenolic-compounds-isolated-from-ethyl-acetate-fraction-of-acacia-hydaspica-r-parker
#5
Tayyaba Afsar, Suhail Razak, Maria Shabbir, Muhammad Rashid Khan
BACKGROUND: Acacia hydaspica belongs to family leguminosae possess antioxidant, anti-inflammatory and anticancer activities. During our search for antioxidant compounds from A. hydaspica, we carried out bioassay guided fractionation and obtained antioxidant compounds with free radical scavenging activity. MATERIALS AND METHODS: The polyphenol compounds in the plant extract of A. hydaspica were isolated by combination of different chromatographic techniques involving vacuum liquid chromatography and medium pressure liquid chromatography...
January 25, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29364057/gas-phase-elemental-mercury-removal-using-ammonium-chloride-impregnated-sargassum-chars
#6
Wei Yang, Ye Shan, Shuai Ding, Xuan Han, Yangxian Liu, Jianfeng Pan
In this article, pyrolyzed bio-chars derived from a kind of macroalgae, sargassum, were modified by ammonium chloride (NH4 Cl) impregnation, and were applied to remove Hg0 from flue gas. The characteristics of sorbents were investigated by the Brunauer-Emmett-Teller, X-ray photoelectron spectroscopy, scanning electron microscopy and ultimate and proximate analysis. The key parameters (e.g. loading value, reaction temperature and concentration of O2 , NO, SO2 and water vapor), kinetics analysis and reaction mechanism of Hg0 removal were investigated...
February 7, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29332795/polymer-based-materials-modified-with-magnetite-nanoparticles-for-enrichment-of-phospholipids
#7
I Ten-Doménech, H Martínez-Pérez-Cejuela, E F Simó-Alfonso, S Torres-Cartas, S Meseguer-Lloret, J M Herrero-Martínez
A polymeric material modified with magnetic nanoparticles (MNPs) has been synthesized and evaluated as sorbent both for solid-phase extraction (SPE) and dispersive magnetic solid-phase extraction (MSPE) of phospholipids (PLs) in human milk samples. The synthesized sorbent was characterized by scanning electron microscopy and its iron content was also determined. Several experimental variables that affect the extraction performance (e.g. loading solvent, breakthrough volume and loading capacity) were investigated and a comparison between conventional SPE and MSPE modalities was done...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29303753/the-effect-of-home-bleaching-carbamide-peroxide-concentration-on-the-microhardness-of-dental-composite-resins
#8
Behnaz Esmaeili, Faezeh Abolghasemzadeh, Atefeh Gholampor, Ghazaleh Daryakenari
Bleaching is a conservative treatment for discolored teeth, but the effect of this treatment on newer, silorane-based composite resins is unclear. This study evaluated the effect of at-home bleaching on the microhardness of methacrylate- and silorane-based composites. Forty blocks each of a methacrylate-based composite and a silorane-based composite were prepared. The 80 specimens were tested in 8 groups (n = 10): 2 composites, each exposed to 3 different carbamide peroxide concentrations (10%, 16%, or 22%) as well as distilled water (control)...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29073465/mechanical-stability-corrosion-resistance-of-superhydrophobic-steel-and-repairable-durability-of-its-slippery-surface
#9
Xiaoyu Gao, Zhiguang Guo
A simple way of chemical etching with H2 SO4 and H2 O2 was employed to prepare a superhydrophobic steel surface with a water contact angle of 163.5° and a sliding angle of about 0°, in addition to modification with 1H,1H,2H,2H-perfluoroalkyltriethoxysilane (FAS-13). On the basis of perfluropolyethers (PFPE) infusion, a slippery liquid-infused porous surface (SLIPS) was fabricated that had a water contact angle of 115.6° and a sliding angle of 2.27°. The prepared sample can still maintain superhydrophobicity after moving 100 cm on 1000 # sandpaper under 100 g loading via an abrasion test, while its corrosion resistance was exhibited via more positive corrosion potentials (Ecorr ) and lower corrosion current densities (Icorr ) in electrochemical corrosion tests with various solutions...
February 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29056408/effect-of-gravitational-gradients-on-cardiac-filling-and-performance
#10
Kazuaki Negishi, Allen G Borowski, Zoran B Popović, Neil L Greenberg, David S Martin, Michael W Bungo, Benjamin D Levine, James D Thomas
BACKGROUND: Gravity affects every aspect of cardiac performance. When gravitational gradients are at their greatest on Earth (i.e., during upright posture), orthostatic intolerance may ensue and is a common clinical problem that appears to be exacerbated by the adaptation to spaceflight. We sought to elucidate the alterations in cardiac performance during preload reduction with progressive upright tilt that are relevant both for space exploration and the upright posture, particularly the preload dependence of various parameters of cardiovascular performance...
December 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28993331/evaluation-of-pharmacokinetic-pharmacodynamic-model-based-optimized-combination-regimens-against-multidrug-resistant-pseudomonas-aeruginosa-in-a-murine-thigh-infection-model-by-using-humanized-dosing-schemes
#11
Rajbharan Yadav, Jürgen B Bulitta, Jiping Wang, Roger L Nation, Cornelia B Landersdorfer
We previously optimized imipenem and tobramycin combination regimens against a double-resistant clinical Pseudomonas aeruginosa isolate by using in vitro infection models, mechanism-based pharmacokinetic/pharmacodynamic modeling (MBM), and Monte Carlo simulations. The current study aimed to evaluate these regimens in a neutropenic murine thigh infection model and to characterize the time course of bacterial killing and regrowth via MBM. We studied monotherapies and combinations of imipenem with tobramycin in vivo against the double-resistant clinical P...
December 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28884429/effects-of-hypergravity-on-gene-levels-in-anti-gravity-muscle-and-bone-through-the-vestibular-system-in-mice
#12
Naoyuki Kawao, Hironobu Morita, Kazuaki Nishida, Koji Obata, Kohei Tatsumi, Hiroshi Kaji
We recently reported that hypergravity with 3 g for 4 weeks affects muscle and bone through the vestibular system in mice. The purpose of this study was to investigate the effects of hypergravity with 2 g, which had no influence on circulating glucocorticoid level, on the gene levels in muscle and bone, as well as the roles of the vestibular system in those changes using vestibular lesioned (VL) mice. Hypergravity for 2 and 8 weeks or VL exerted little effects on the mRNA levels of muscle differentiation factors and myokines in the soleus muscle...
September 7, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28805973/experimental-and-clinical-evidence-of-differential-effects-of-magnesium-sulfate-on-neuroprotection-and-angiogenesis-in-the-fetal-brain
#13
Matthieu Lecuyer, Marina Rubio, Clément Chollat, Maryline Lecointre, Sylvie Jégou, Philippe Leroux, Carine Cleren, Isabelle Leroux-Nicollet, Loic Marpeau, Denis Vivien, Stéphane Marret, Bruno J Gonzalez
Clinical studies showed beneficial effects of magnesium sulfate regarding the risk of cerebral palsy. However, regimen protocols fluctuate worldwide and risks of adverse effects impacting the vascular system have been reported for human neonates, keeping open the question of the optimal dosing. Using clinically relevant concentrations and doses of magnesium sulfate, experiments consisted of characterizing, respectively, ex vivo and in vivo, the effects of magnesium sulfate on the nervous and vascular systems of mouse neonates by targeting neuroprotection, angiogenesis, and hemodynamic factors and in measuring, in human fetuses, the impact of a 4-g neuroprotective loading dose of magnesium sulfate on brain hemodynamic parameters...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28748713/qbd-for-pediatric-oral-lyophilisates-development-risk-assessment-followed-by-screening-and-optimization
#14
Tibor Casian, Sonia Iurian, Catalina Bogdan, Lucia Rus, Mirela Moldovan, Ioan Tomuta
OBJECTIVE: This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. METHODS: Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodology related parameters. Failure Mode Effect Analysis was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance...
December 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28746995/desorption-of-radioactive-cesium-by-seawater-from-the-suspended-particles-in-river-water
#15
Masaki Onodera, Akira Kirishima, Seiya Nagao, Kouichi Takamiya, Tsutomu Ohtsuki, Daisuke Akiyama, Nobuaki Sato
In 2011, the accident at the Fukushima-Daiichi nuclear power plant dispersed radioactive cesium throughout the environment, contaminating the land, rivers, and sea. Suspended particles containing clay minerals are the transportation medium for radioactive cesium from rivers to the ocean because cesium is strongly adsorbed between the layers of clay minerals, forming inner sphere complexes. In this study, the adsorption and desorption behaviors of radioactive cesium from suspended clay particles in river water have been investigated...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28642926/the-combined-effect-of-food-simulating-solutions-brushing-and-staining-on-color-stability-of-composite-resins
#16
Tânia Mara Da Silva, Ana Luísa Leme Simões Sales, Cesar Rogerio Pucci, Alessandra Bühler Borges, Carlos Rocha Gomes Torres
Objective: This study evaluated the effect of food-simulating media associated with brushing and coffee staining on color stability of different composite resins. Materials and methods: Eighty specimens were prepared for each composite: Grandio SO (Voco), Amaris (Voco), Filtek Z350XT (3M/ESPE), Filtek P90 (3M/ESPE). They were divided into four groups according to food-simulating media for 7 days: artificial saliva (control), heptane, citric acid and ethanol. The composite surface was submitted to 10,950 brushing cycles (200 g load) in an automatic toothbrushing machine...
January 2017: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28580400/replacement-of-daily-load-attenuates-but-does-not-prevent-changes-to-the-musculoskeletal-system-during-bed-rest
#17
Peter R Cavanagh, Andrea J Rice, Sara C Novotny, Kerim O Genc, Ricki K Englehaupt, Tammy M Owings, Bryan Comstock, Tamre Cardoso, Hakan Ilaslan, Scott M Smith, Angelo A Licata
The dose-response effects of exercise in reduced gravity on musculoskeletal health have not been well documented. It is not known whether or not individualized exercise prescriptions can be effective in preventing the substantial loss in bone mineral density and muscle function that have been observed in space flight and in bed rest. In this study, typical daily loads to the lower extremities were quantified in free-living subjects who were then randomly assigned to control or exercise groups. Subjects were confined to 6-degree head-down bed rest for 84 days...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28574173/interaction-between-toothpaste-abrasivity-and-toothbrush-filament-stiffness-on-the-development-of-erosive-abrasive-lesions-in-vitro
#18
Frank Lippert, Mona A Arrageg, George J Eckert, Anderson T Hara
OBJECTIVES: To investigate the loss of enamel and dentin surface caused by the interaction between abrasives in toothpaste and toothbrush filament stiffness. METHODS: The study followed a 2 (high-level or low-level abrasive; silica) × 3 (filament stiffness; soft, medium or hard) × 2 (cycling time; 3 or 5 days) factorial design. Polished bovine enamel and dentin specimens (n = 8 each per group) were subjected to 5 days of erosion/abrasion cycling: erosion (5 minutes, four times daily, 0...
June 2, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28572567/ultrasensitive-multi-functional-flexible-sensors-based-on-organic-field-effect-transistors-with-polymer-dispersed-liquid-crystal-sensing-layers
#19
Myeonghun Song, Jooyeok Seo, Hwajeong Kim, Youngkyoo Kim
Ultrasensitive flexible sensors with multi-sensing functions are required for various applications in flexible electronics era. Here we demonstrate flexible polymer-dispersed liquid crystal (PDLC)-integrated-organic field-effect transistors (OFETs) (PDLC-i-OFETs), which sensitively respond to various stimulations including weak gas (air) flow, direct physical touch, light, and heat. The flexible PDLC-i-OFETs were fabricated by spin-coating the poly(methyl methacrylate) (PMMA)-dispersed 4,4'-pentyl-cyanobiphenyl (5CB) layers on the poly(3-hexylthiophene) (P3HT) channel layers of OFETs with 200 μm-thick poly(ethylene naphthalate) (PEN) substrates...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279430/coupled-disturbance-observer-based-position-tracking-control-for-a-cascade-electro-hydraulic-system
#20
Qing Guo, Jing-Min Yin, Tian Yu, Dan Jiang
The disturbance suppression is one of the most common control problems in electro-hydraulic systems. especially largely an unknown disturbance often obviously degrades the dynamic performance by biasing the desired actuator outputs (e.g., load forces or torques). In order to reject the dynamic disturbances in some multi-degree-of-freedom manipulators driven by electro-hydraulic actuators, this paper proposes a state feedback control of the cascade electro-hydraulic system based on a coupled disturbance observer with backstepping...
May 2017: ISA Transactions
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