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https://www.readbyqxmd.com/read/28641681/the-effects-of-training-on-anxiety-and-task-performance-in-simulated-suborbital-spaceflight
#1
Rebecca S Blue, Frederick Bonato, Kimberly Seaton, Andrea Bubka, Johnené L Vardiman, Charles Mathers, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: In commercial spaceflight, anxiety could become mission-impacting, causing negative experiences or endangering the flight itself. We studied layperson response to four varied-length training programs (ranging from 1 h-2 d of preparation) prior to centrifuge simulation of launch and re-entry acceleration profiles expected during suborbital spaceflight. We examined subject task execution, evaluating performance in high-stress conditions. We sought to identify any trends in demographics, hemodynamics, or similar factors in subjects with the highest anxiety or poorest tolerance of the experience...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28555125/determinants-of-motion-sickness-in-tilting-trains-coriolis-cross-coupling-stimuli-and-tilt-delay
#2
Giovanni Bertolini, Meek Angela Durmaz, Kim Ferrari, Alexander Küffer, Charlotte Lambert, Dominik Straumann
Faster trains require tilting of the cars to counterbalance the centrifugal forces during curves. Motion sensitive passengers, however, complain of discomfort and overt motion sickness. A recent study comparing different control systems in a tilting train, suggested that the delay of car tilts relative to the curve of the track contributes to motion sickness. Other aspects of the motion stimuli, like the lateral accelerations and the car jitters, differed between the tested conditions and prevented a final conclusion on the role of tilt delay...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28539143/incidence-of-g-induced-loss-of-consciousness-and-almost-loss-of-consciousness-in-the-royal-air-force
#3
Ellen Slungaard, Judith McLeod, Nicholas D C Green, Amit Kiran, Di J Newham, Stephen D R Harridge
INTRODUCTION: Exposure to sustained +Gz acceleration with inadequate G protection can result in G-induced loss of consciousness (G-LOC) or almost loss of consciousness (A-LOC). The UK Royal Air Force (RAF) last conducted a survey of G-LOC within their military aircrew in 2005 with interventions subsequently introduced. The aim of this study was to repeat the 2005 survey in order to evaluate the impact of those interventions. METHODS: An anonymous questionnaire requesting details of G-LOC and A-LOC events was mailed to all RAF pilots (N = 1878) and weapons systems operators (WSOs) (N = 473), irrespective of aircraft currently flown...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28459050/assessing-volumetric-absorptive-microsampling-coupled-with-stable-isotope-dilution-assay-and-liquid-chromatography-tandem-mass-spectrometry-as-potential-diagnostic-tool-for-whole-blood-5-methyltetrahydrofolic-acid
#4
Markus Kopp, Michael Rychlik
Volumetric absorptive microsamplers (VAMS) have been developed recently as a promising tool for clinical blood sampling. Compared to dried blood spot samples analyzed by accurate stable isotope dilution assays (SIDAs), the new technique could provide further substantial miniaturizing of folate assays by eliminating hematocrit effects and uneven analyte distribution within the sample. Herein, we present a miniaturized SIDA coupled with LC-MS/MS measurement of 5-methyltetrahydrofolic acid as main folate vitamer in whole blood (WB) using [(13)C5]-5-methyltetrahydrofolic acid as internal standard...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28262856/resting-serum-concentration-of-high-sensitivity-c-reactive-protein-hs-crp-in-sportsmen-and-untrained-male-adults
#5
COMPARATIVE STUDY
F A Niyi-Odumosu, O A Bello, S A Biliaminu, B V Owoyele, T O Abu, O L Dominic
There is an inverse relationship between regular physical activity and concentration of serum inflammatory markers, with variations in resting CRP in trained and untrained subjects. The effect of acute and prolonged exercises has been studied on inflammatory markers with dearth of information and controversies on the resting serum values of high sensitivity CRP (hs-CRP). Therefore, this study sought to identify and compare variations that occur in serum levels of high sensitivity CRP in groups of sportsmen (6) and physically active untrained subjects...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28182858/effect-of-exercise-induced-dehydration-on-circulatory-markers-of-oxidative-damage-and-antioxidant-capacity
#6
Vincent P Georgescu, Tacito P de Souza Junior, Christian Behrens, Marcelo P Barros, Carlos Alves Bueno, Alan C Utter, Lisa S McAnulty, Steven R McAnulty
Dehydration is a common event associated with exercise. However, few studies have examined the effects of dehydration on plasma redox status in humans. Eighty-two athletes were recruited and baseline anthropometrics and blood samples were obtained. Athletes then engaged in a dehydration protocol, training until 3% of preweight body mass was lost. Athletes returned to the lab and had postdehydration blood collected. Athletes then consumed an isotonic drink until pre-exercise body weight was reestablished. Blood was then recollected (1 h post full rehydration (PFR))...
February 9, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28107395/prevalence-of-pre-analytical-errors-in-clinical-chemistry-diagnostic-labs-in-sulaimani-city-of-iraqi-kurdistan
#7
Dereen Najat
BACKGROUND: Laboratory testing is roughly divided into three phases: a pre-analytical phase, an analytical phase and a post-analytical phase. Most analytical errors have been attributed to the analytical phase. However, recent studies have shown that up to 70% of analytical errors reflect the pre-analytical phase. The pre-analytical phase comprises all processes from the time a laboratory request is made by a physician until the specimen is analyzed at the lab. Generally, the pre-analytical phase includes patient preparation, specimen transportation, specimen collection and storage...
2017: PloS One
https://www.readbyqxmd.com/read/28095952/neck-and-shoulder-muscle-activation-among-experienced-and-inexperienced-pilots-in-gz-exposure
#8
Tuomas Honkanen, Juha Oksa, Matti J Mäntysaari, Heikki Kyröläinen, Janne Avela
BACKGROUND: The aim of the present study was to compare differences in electromyography (EMG) activation of the neck and shoulder muscles between groups of inexperienced and experienced pilots during controlled +Gz exposure in a centrifuge. METHODS: The subjects were volunteer cadets (inexperienced group) and lieutenants (experienced group) undergoing their first centrifuge training. The first group did not have any high performance aircraft (HPA) experience, while the latter one had a 1-yr experience of intense flying of HPA...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28064225/influence-of-mechanical-force-on-bone-matrix-proteins-in-ovariectomised-mice-and-osteoblast-like-mc3t3-e1-cells
#9
Meng Zhang, Shintaro Ishikawa, Tomoko Inagawa, Hideshi Ikemoto, Shiyu Guo, Masataka Sunagawa, Tadashi Hisamitsu
AIM: To investigate the effect of mechanical stress on periostin and semaphorin-3A expression in a murine model of postmenopausal osteoporosis and in osteoblast-like MC3T3-E1 cells. MATERIALS AND METHODS: Female mice were divided into three groups and treated with a sham operation, ovariectomy (OVX) or OVX plus treadmill training (OVX+Run). After 10 weeks, tibias were used for histological analysis. MC3T3-E1 cells were burdened by mechanical stress using a centrifuge or were treated with periostin, and the production of biologically-active semaphorin-3A was examined in vitro...
January 2, 2017: In Vivo
https://www.readbyqxmd.com/read/27956775/relationship-between-hepcidin-and-oxidant-antioxidant-status-in-calves-with-suspected-neonatal-septicemia
#10
E E Erkilic, H M Erdogan, M Ogun, A H Kirmizigul, E Gokce, M Kuru, A Kukurt
AIM: This study has been conducted for the purpose of determining serum hepcidin, total antioxidant status (TAS), total oxidant status (TOS), and Fe levels in calves with suspected neonatal septicemia before and after treatment and the clinical significance of hepcidin in calves with suspected neonatal septicemia. MATERIALS AND METHODS: The study material consisted of 15 calves of different ages and sexes brought to the Training, Research and Application Center at the Kafkas University Faculty of Veterinary Medicine with suspected neonatal septicemia...
November 2016: Veterinary World
https://www.readbyqxmd.com/read/27901267/binge-alcohol-intake-after-hypergravity-stress-sustainably-decreases-ampk-and-transcription-factors-necessary-for-hepatocyte-survival
#11
Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung, Sang Geon Kim
BACKGROUND: Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#12
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27713998/diagnosis-of-iron-deficiency-anemia-using-density-based-fractionation-of-red-blood-cells
#13
Jonathan W Hennek, Ashok A Kumar, Alex B Wiltschko, Matthew R Patton, Si Yi Ryan Lee, Carlo Brugnara, Ryan P Adams, George M Whitesides
Iron deficiency anemia (IDA) is a nutritional disorder that impacts over one billion people worldwide; it may cause permanent cognitive impairment in children, fatigue in adults, and suboptimal outcomes in pregnancy. IDA can be diagnosed by detection of red blood cells (RBCs) that are characteristically small (microcytic) and deficient in hemoglobin (hypochromic), typically by examining the results of a complete blood count performed by a hematology analyzer. These instruments are expensive, not portable, and require trained personnel; they are, therefore, unavailable in many low-resource settings...
October 5, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27662351/screening-and-mitigation-of-layperson-anxiety-in-aerospace-environments
#14
REVIEW
Robert A Mulcahy, Rebecca S Blue, Johnené L Vardiman, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: Anxiety may present challenges for commercial spaceflight operations, as little is known regarding the psychological effects of spaceflight on laypersons. A recent investigation evaluated measures of anxiety during centrifuge-simulated suborbital commercial spaceflight, highlighting the potential for severe anxiousness to interrupt spaceflight operations. METHODS: To pave the way for future research, an extensive literature review identified existing knowledge that may contribute to formation of interventions for anxiety in commercial spaceflight...
2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27503047/a-report-of-transverse-process-fractures-secondary-to-the-centrifuge-in-a-healthy-aviator
#15
Matthew A Puderbaugh
BACKGROUND: Centrifuge training, while an integral component in pilot training, is not without risks. To date there has never been a reported case of isolated transverse process fractures associated with centrifuge training. CASE REPORT: A 32-yr-old Flight Surgeon underwent centrifuge training as part of an educational course. She had increasing back pain after exposure to the centrifuge. Follow-up studies showed left L2 and bilateral L3 transverse process fractures...
July 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27383135/an-artificial-neural-network-based-analysis-of-factors-controlling-particle-size-in-a-virgin-coconut-oil-based-nanoemulsion-system-containing-copper-peptide
#16
Shazwani Samson, Mahiran Basri, Hamid Reza Fard Masoumi, Emilia Abdul Malek, Roghayeh Abedi Karjiban
A predictive model of a virgin coconut oil (VCO) nanoemulsion system for the topical delivery of copper peptide (an anti-aging compound) was developed using an artificial neural network (ANN) to investigate the factors that influence particle size. Four independent variables including the amount of VCO, Tween 80: Pluronic F68 (T80:PF68), xanthan gum and water were the inputs whereas particle size was taken as the response for the trained network. Genetic algorithms (GA) were used to model the data which were divided into training sets, testing sets and validation sets...
2016: PloS One
https://www.readbyqxmd.com/read/27272509/a-single-center-s-conversion-from-roller-pump-to-centrifugal-pump-technology-in-extracorporeal-membrane-oxygenation
#17
Brandon C Shade, Kellie Schiavo, Tami Rosenthal, James T Connelly, Richard W Melchior
OVERVIEW: Recent advances in blood pump technology have led to an increased use of centrifugal pumps for prolonged extracorporeal membrane oxygenation (ECMO). Data from the Extracorporeal Life Support Organization confirms that many institutions have converted to centrifugal pumps after prior experience with roller pump technology. Centrifugal pump technology is more compact and may generate less heat and hemolysis than a conventional roller pump. Based on the potential advantages of centrifugal pumps, a decision was made institution-wide to convert to centrifugal pump technology in pediatric implementation of ECMO...
June 5, 2016: Perfusion
https://www.readbyqxmd.com/read/27260813/diagnosing-feline-immunodeficiency-virus-fiv-infection-in-fiv-vaccinated-and-fiv-unvaccinated-cats-using-saliva
#18
Mark E Westman, Richard Malik, Evelyn Hall, Jacqueline M Norris
We recently showed that two immunochromatography point-of-care FIV antibody test kits (Witness FeLV/FIV and Anigen Rapid FIV/FeLV) were able to correctly assign FIV infection status, irrespective of FIV vaccination history, using whole blood as the diagnostic specimen. A third FIV antibody test kit, SNAP FIV/FeLV Combo (an enzyme-linked immunosorbent assay [ELISA]), was unable to differentiate antibodies produced in response to FIV vaccination from those incited by FIV infection. The aim of this study was to determine if saliva is a suitable diagnostic specimen using the same well characterized feline cohort...
June 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27130139/postnatal-training-of-129-sv-mice-confirms-the-long-term-influence-of-early-exercising-on-the-motor-properties-of-mice
#19
Najet Serradj, Marc Jamon
A previous study showed that motor experiences during critical periods of development durably affect the motor properties of adult C57BL/6J mice. However, dependence on early environmental features may vary with the genetic profile. To evaluate the contribution of the genetic background on external influences to motricity, we performed the same experiment in a 129/Sv mouse strain that show a strongly different motor profile. Mice were subjected to endurance training (enriched environment or forced treadmill), hypergravity (chronic centrifugation), or simulated microgravity (hindlimb unloading) between postnatal days 10 and 30...
September 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27099085/g-protection-when-adding-pressurized-sleeves-and-gloves-to-a-representative-g-suit-ensemble
#20
Thomas R Morgan, Ulf Balldin, Joseph R Fischer
BACKGROUND: In a previous study, pressurized sleeves and gloves were found to substantially diminish or eliminate G-induced arm pain. Since this equipment presumably acts similarly to a G suit for the arms and hands, it was hypothesized that higher inflation pressures might provide an additional increment of G protection. METHODS: In a human-rated centrifuge, 15 well trained subjects using Combat Edge and ATAGS G-protective equipment were exposed to gradual and rapid onset relaxed G exposures as well as rapid onset straining and simulated aerial combat maneuver G exposures up to + 9 Gz with and without pressurized sleeves and gloves...
May 2016: Aerospace Medicine and Human Performance
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