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https://www.readbyqxmd.com/read/28093423/medical-and-psychosocial-factors-associated-with-antibiotic-prescribing-in-primary-care-survey-questionnaire-and-factor-analysis
#1
Tau-Hong Lee, Joshua Gx Wong, David Cb Lye, Mark Ic Chen, Victor Wk Loh, Yee-Sin Leo, Linda K Lee, Angela Lp Chow
BACKGROUND: Acute upper respiratory infections (AURI) are the leading causes of antibiotic prescribing in primary care although antibiotics are often not indicated. AIM: To gain an understanding of the knowledge, attitudes, and practices (KAP) of GPs in Singapore and the associated latent factors to guide the implementation of an effective programme to reduce antibiotic use in primary care. DESIGN AND SETTING: An anonymous survey on the KAP of antibiotic use in AURI of GPs in Singapore...
January 16, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28081476/electron-spin-relaxation-of-a-boron-containing-heterocyclic-radical
#2
Sandra S Eaton, Kirby Huber, Hanan Elajaili, Joseph McPeak, Gareth R Eaton, Lauren E Longobardi, Douglas W Stephan
Preparation of the stable boron-containing heterocyclic phenanthrenedione radical, (C6F5)2B(O2C14H8), by frustrated Lewis pair chemistry has been reported recently. Electron paramagnetic resonance measurements of this radical were made at X-band in toluene:dichloromethane (9:1) from 10 to 293K, in toluene from 180 to 293K and at Q-band at 80K. In well-deoxygenated 0.1mM toluene solution at room temperature hyperfine splittings from (11)B, four pairs of (1)H, and 5 pairs of (19)F contribute to an EPR spectrum with many resolved lines...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28028556/effect-of-intravenous-gadoxetate-disodium-and-flip-angle-on-hepatic-proton-density-fat-fraction-estimation-with-six-echo-gradient-recalled-echo-magnitude-based-mr-imaging-at-3t
#3
Charlie C Park, Gavin Hamilton, Ajinkya Desai, Kevin A Zand, Tanya Wolfson, Jonathan C Hooker, Eduardo Costa, Elhamy Heba, Lisa Clark, Anthony Gamst, Rohit Loomba, Michael S Middleton, Claude B Sirlin
PURPOSE: The aim of the study was to determine in patients undergoing gadoxetate disodium (Gx)-enhanced MR exams whether proton density fat fraction (PDFF) estimation accuracy of magnitude-based multi-gradient-echo MRI (MRI-M) could be improved by using high flip angle (FA) on post-contrast images. MATERIALS AND METHODS: Thirty-one adults with known or suspected hepatic steatosis undergoing 3T clinical Gx-enhanced liver MRI were enrolled prospectively. MR spectroscopy (MRS), the reference standard, was performed before Gx to measure MRS-PDFF...
December 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27995869/evaluation-of-xpert-mrsa-gen-3-and-bd-max-mrsa-xt-for-meticillin-resistant-staphylococcusaureus-screening-in-a-routine-diagnostic-setting-in-a-low-prevalence-area
#4
Xiaohui Chen Nielsen, Tina Vasehus Madsen, Jørgen Engberg
Screening and pre-emptive isolation of at-risk patients are important aspects of the Danish approach to the prevention of meticillin-resistant Staphylococcusaureus (MRSA) infection, but screening with conventional culture can take up to 3 days for results to become available with attendant costs and disadvantages of prolonged isolation. We sought to evaluate the accuracy, time to availability of results and potential economic benefits of two next-generation MRSA screening assays, Xpert MRSA Gen 3 (GX MRSA) and BD MAX MRSA XT, in a setting of a consolidated laboratory serving a number of hospitals with a low prevalence of MRSA and using enrichment culture as a reference method...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27957647/dosimetry-in-micro-computed-tomography-a-review-of-the-measurement-methods-impacts-and-characterization-of-the-quantum-gx-imaging-system
#5
Jeffrey A Meganck, Bob Liu
PURPOSE: X-ray micro-computed tomography (μCT) is a widely used imaging modality in preclinical research with applications in many areas including orthopedics, pulmonology, oncology, cardiology, and infectious disease. X-rays are a form of ionizing radiation and, therefore, can potentially induce damage and cause detrimental effects. Previous reviews have touched on these effects but have not comprehensively covered the possible implications on study results. Furthermore, interpreting data across these studies is difficult because there is no widely accepted dose characterization methodology for preclinical μCT...
December 12, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27936002/the-significance-of-prolonged-and-saddleback-fever-in-hospitalised-adult-dengue
#6
Deborah Hl Ng, Joshua Gx Wong, Tun-Linn Thein, Yee-Sin Leo, David C Lye
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in dengue. This study aims to examine the prevalence of prolonged and saddleback fever in dengue as well as their associations with dengue severity. A total of 2843 polymerase-chain reaction (PCR) confirmed dengue patients admitted to Tan Tock Seng Hospital from 2004 to 2008 were included in the study...
2016: PloS One
https://www.readbyqxmd.com/read/27900175/free-fall-acrobatics-to-reduce-neck-loads-during-parachute-opening-shock-evaluation-of-an-intervention-acropose
#7
Anton Westman, Björn O Äng
INTRODUCTION: Neck pain is a widespread health problem in the skydiver athlete population, epidemiologically linked to repeated exposure to parachute opening shock (POS). During POS, a parachutist is subjected to considerable deceleration forces. This study aims to evaluate the use of preventive free fall acrobatics to reduce the biomechanical load on the neck of parachutists during parachute opening. METHODS AND ANALYSIS: Interventional study with a cross-over, within-subject, repeated measures design...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27879019/screening-for-alk-abnormalities-in-central-nervous-system-metastases-of-non-small-cell-lung-cancer-alk-abnormalities-in-cns-metastases-of-nsclc
#8
Marcin Nicoś, Bożena Jarosz, Paweł Krawczyk, Kamila Wojas-Krawczyk, Tomasz Kucharczyk, Marek Sawicki, Juliusz Pankowski, Tomasz Trojanowski, Janusz Milanowski
Anaplastic lymphoma kinase (ALK) gene rearrangement was reported in 3-7% of primary non-small-cell lung cancer (NSCLC) and its presence is commonly associated with adenocarcinoma (AD) type and non-smoking history. ALK tyrosine kinase inhibitors (TKIs) such as crizotinib, alectinib and ceritinib showed efficiency in patients with primary NSCLC harboring ALK gene rearrangement. Moreover, response to ALK TKIs was observed in central nervous system (CNS) metastatic lesions of NSCLC. However, there are no reports concerning the frequency of ALK rearrangement in CNS metastases...
November 23, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27824867/microrna-expression-patterns-of-cd8-t-cells-in-acute-and-chronic-brucellosis
#9
Ferah Budak, S Haldun Bal, Gulcin Tezcan, Furkan Guvenc, E Halis Akalin, Guher Goral, Gunnur Deniz, H Barbaros Oral
Although our knowledge about Brucella virulence factors and the host response increase rapidly, the mechanisms of immune evasion by the pathogen and causes of chronic disease are still unknown. Here, we aimed to investigate the immunological factors which belong to CD8+ T cells and their roles in the transition of brucellosis from acute to chronic infection. Using miRNA microarray, more than 2000 miRNAs were screened in CD8+ T cells of patients with acute or chronic brucellosis and healthy controls that were sorted from peripheral blood with flow cytometry and validated through qRT-PCR...
2016: PloS One
https://www.readbyqxmd.com/read/27802032/uncovering-the-role-of-oxygen-atom-transfer-in-ru-based-catalytic-water-oxidation
#10
Dooshaye Moonshiram, Yuliana Pineda-Galvan, Darren Erdman, Mark Palenik, Ruifa Zong, Randolph Thummel, Yulia Pushkar
The realization of artificial photosynthesis carries the promise of cheap and abundant energy, however, significant advances in the rational design of water oxidation catalysts are required. Detailed information on the structure of the catalyst under reaction conditions and mechanisms of O-O bond formation should be obtained. Here, we used a combination of electron paramagnetic resonance (EPR), stopped flow freeze quench on a millisecond-second time scale, X-ray absorption (XAS), resonance Raman (RR) spectroscopy, and density functional theory (DFT) to follow the dynamics of the Ru-based single site catalyst, [Ru(II)(NPM)(4-pic)2(H2O)](2+) (NPM = 4-t-butyl-2,6-di(1',8'-naphthyrid-2'-yl)pyridine, pic = 4-picoline), under the water oxidation conditions...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27722424/determination-of-physical-emulsion-stabilization-mechanisms-of-wood-hemicelluloses-via-rheological-and-interfacial-characterization
#11
K S Mikkonen, D Merger, P Kilpeläinen, L Murtomäki, U S Schmidt, M Wilhelm
Materials manufacturing industries seek efficient, economic, and sustainable compounds for stabilizing dispersed systems such as emulsions. In this study, novel, abundant biobased hydrocolloids spruce galactoglucomannans (GGM) and birch glucuronoxylans (GX) were obtained from a forestry biorefining process and characterized as versatile stabilizers of rapeseed oil-in-water emulsions. For the first time, GGM and GX isolated by pressurized hot water extraction (PHWE) of spruce and birch saw meal, respectively, were studied in emulsions...
September 27, 2016: Soft Matter
https://www.readbyqxmd.com/read/27722176/altered-expressions-of-mir-1238-3p-mir-494-mir-6069-and-mir-139-3p-in-the-formation-of-chronic-brucellosis
#12
Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Halis Akalın, Guher Goral, Haluk Barbaros Oral
Brucellosis is a zoonotic disease that is still endemic in developing countries. Despite early diagnosis and treatment of patients, chronic infections are seen in 10-30% of patients. In this study, we aimed to investigate the immunological factors that play roles in the transition of brucellosis from acute infection into chronic infection. Here, more than 2000 miRNAs were screened in peripheral blood mononuclear cells (PBMCs) of patients with acute or chronic brucellosis and healthy controls by using miRNA array, and the results of the miRNA array were validated through qRT-PCR...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27706792/retraction-of-articles-with-plagiarism-in-common-with-other-publications
#13
(no author information available yet)
The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract these articles. The authors and their institutions were advised of this serious breach of ethics...
September 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27687221/kinetic-of-orange-pigment-production-from-monascus-ruber-on-submerged-fermentation
#14
Francielo Vendruscolo, Willibaldo Schmidell, Débora de Oliveira, Jorge Luiz Ninow
Pigments produced by species of Monascus have been used to coloring rice, meat, sauces, wines and beers in East Asian countries. Monascus can produce orange (precursor), yellow and red pigments. Orange pigments have low solubility in culture media and when react with amino groups they become red and largely soluble. The orange pigments are an alternative to industrial pigment production because the low solubility facilitates the downstream operations. The aim of this work was to study the kinetic on the production of orange pigments by Monascus ruber CCT 3802...
January 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27672211/epr-studies-of-wild-type-and-mutant-dre2-identify-essential-2fe-2s-and-4fe-4s-clusters-and-their-cysteine-ligands
#15
Yan Zhang, Chunyu Yang, Andrew Dancis, Eiko Nakamaru-Ogiso
Yeast Dre2 (anamorsin or CIAPIN1) is an essential component for cytosolic Fe/S cluster biosynthesis. The C-terminal domain contains eight evolutionarily conserved cysteine residues, and we previously demonstrated that the yeast Dre2 overexpressed in Escherichia coli contains one binuclear ([2Fe-2S]) cluster and one tetranuclear ([4Fe-4S]) cluster. In this study, we replaced each conserved cysteine with alanine and analyzed the effects by Electron Paramagnetic Resonance. Although the C311A mutant lacked both signals, our data clearly suggest that the [2Fe-2S] cluster is ligated to Cys252, Cys263, Cys266 and Cys268, whereas the [4Fe-4S] cluster is ligated to Cys311, Cys314, Cys322 and Cys325...
January 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/27652357/evaluation-of-genexpert-mtb-rif-assay-for-direct-diagnosis-of-pulmonary-tuberculosis
#16
Husseiny Sh Moussa, Faten S Bayoumi, Ahmed M Ali
OBJECTIVES: To evaluate the performance of GeneXpert MTB/RIF assay for direct diagnosis of pulmonary tuberculosis (PTB).   METHODS: This is a cross-sectional study conducted between October 2013 and February 2016 at Abbassaia Chest Hospital and Ain Shams University Hospital, Cairo, Egypt. Inclusion criteria were adults between 18 and 60 years with suspected PTB and classified into 5 clinical categories based on their clinical, radiological, and laboratory findings:  confirmed TB, probable TB, possible TB, unlikely TB, and not TB...
October 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27634299/observation-of-re-entrant-spin-reorientation-in-tbfe1-xmnxo3
#17
Yifei Fang, Ya Yang, Xinzhi Liu, Jian Kang, Lijie Hao, Xiping Chen, Lei Xie, Guangai Sun, Venkatesh Chandragiri, Chin-Wei Wang, Yiming Cao, Fei Chen, Yuntao Liu, Dongfeng Chen, Shixun Cao, Chengtian Lin, Wei Ren, Jincang Zhang
We report a spin reorientation from Γ4(Gx, Ay, Fz) to Γ1(Ax, Gy, Cz) magnetic configuration near room temperature and a re-entrant transition from Γ1(Ax, Gy, Cz) to Γ4(Gx, Ay, Fz) at low temperature in TbFe1-xMnxO3 single crystals by performing both magnetization and neutron diffraction measurements. The Γ4 - Γ1 spin reorientation temperature can be enhanced to room temperature when x is around 0.5 ~ 0.6. These new transitions are distinct from the well-known Γ4 - Γ2 transition observed in TbFeO3, and the sinusoidal antiferromagnetism to complex spiral magnetism transition observed in multiferroic TbMnO3...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27595702/growth-modelling-of-nitrosomonas-europaea-atcc%C3%A2-19718-and-nitrobacter-winogradskyi-atcc%C3%A2-25391-a-new-online-indicator-of-the-partial-nitrification
#18
Nelly Cruvellier, Laurent Poughon, Catherine Creuly, C-Gilles Dussap, Christophe Lasseur
The aim of the present work was to study the growth of two nitrifying bacteria. For modelling the nitrifying subsystem of the MELiSSA loop, Nitrosomonas europaea ATCC® 19718 and Nitrobacter winogradskyi ATCC® 25931 were grown separately and in cocultures. The kinetic parameters of a stoichiometric mass balanced Pirt model were identified: μmax=0.054h(-1), decay rate b=0.003h(-1) and maintenance rate m=0.135gN-NH4(+)·gX(-1)·h(-1) for Nitrosomonas europaea; μmax=0.024h(-1), b=0.001h(-1) and m=0.467gN-NO2(-)·gX(-1)·h(-1) for Nitrobacter winogradskyi...
November 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27594784/dysregulation-of-protein-kinase-gene-expression-in-nk-cells-from-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients
#19
Anu Chacko, Donald R Staines, Samantha C Johnston, Sonya M Marshall-Gradisnik
BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes in intracellular mitogen-activated protein kinase pathways from isolated NK cells. The purpose of this present investigation was to examine whether protein kinase genes have a role in abnormal NK cell intracellular signaling in CFS/ME...
2016: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/27503240/genetic-and-phylogenetic-analysis-of-a-novel-parvovirus-isolated-from-chickens-in-guangxi-china
#20
Bin Feng, Zhixun Xie, Xianwen Deng, Liji Xie, Zhiqin Xie, Li Huang, Qin Fan, Sisi Luo, Jiaoling Huang, Yanfang Zhang, Tingting Zeng, Sheng Wang, Leyi Wang
A previously unidentified chicken parvovirus (ChPV) strain, associated with runting-stunting syndrome (RSS), is now endemic among chickens in China. To explore the genetic diversity of ChPV strains, we determined the first complete genome sequence of a novel ChPV isolate (GX-CH-PV-7) identified in chickens in Guang Xi, China, and showed moderate genome sequence similarity to reference strains. Analysis showed that the viral genome sequence is 86.4 %-93.9 % identical to those of other ChPVs. Genetic and phylogenetic analyses showed that this newly emergent GX-CH-PV-7 is closely related to Gallus gallus enteric parvovirus isolate ChPV 798 from the USA, indicating that they may share a common ancestor...
November 2016: Archives of Virology
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