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https://www.readbyqxmd.com/read/28521490/transcript-levels-of-ten-eleven-translocation-type-1-3-in-cervical-cancer-and-non-cancerous-cervical-tissues
#1
Dorota Ewa Bronowicka-Kłys, Andrzej Roszak, Piotr Pawlik, Stefan Sajdak, Anna Sowińska, Paweł Piotr Jagodziński
Decreased expression of ten-eleven translocation (TET1, TET2 and TET3) proteins has been reported in various types of cancer. However, the expression levels of TET proteins in cervical cancer (CC) remain to be elucidated. The present study determined the levels of TET1, TET2 and TET3 transcripts in cancerous (n=80) and non-cancerous cervical tissues (n=41). The results revealed a significant reduction in TET1 transcripts (P=0.0000001) in cervical tissue samples from patients with primary CC compared with samples from control patients...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28508481/a-comparison-of-identity-by-descent-and-identity-by-state-matrices-that-are-used-for-genetic-evaluation-and-estimation-of-variance-components
#2
R L Fernando, H Cheng, X Sun, D J Garrick
The genetic covariance matrix conditional on pedigree is proportional to the pedigree-based additive relationship matrix (PARM), which is twice the matrix of identity-by-descent (IBD) probabilities. In genomic prediction, IBD probabilities in the PARM, which are expected genetic similarities between relatives that are derived from the pedigree, are substituted by realized similarities that are derived from genotypes to obtain a genomic additive relationship matrix (GARM). Different definitions of similarity lead to different GARMs, and two commonly used GARMS are the matrix G, which is based on an allele substitution effect model, and the matrix T, which is based on an allele effect model...
June 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28459004/immobilization-of-calb-on-activated-chitosan-application-to-enzymatic-synthesis-in-supercritical-and-near-critical-carbon-dioxide
#3
José C S Dos Santos, Horacio L Bonazza, Leonardo J B L de Matos, Elizabete A Carneiro, Oveimar Barbosa, Roberto Fernandez-Lafuente, Luciana R B Gonçalves, Hosiberto B de Sant' Ana, Rílvia S Santiago-Aguiar
The objective of this new paper was to evaluate the enzymatic esterification reaction conducted in supercritical or near-critical CO2, catalyzed by immobilized lipase B from Candida antarctica (CALB). The biocatalyst was prepared through the immobilization of CALB by covalent attachment using chitosan sequentially activated with Glycidol, ethylenediamine (EDA) and glutaraldehyde as support. In order to determine the best operational conditions of the esterification reaction (1: 1 (alcohol-acid); biocatalyst content, 10% (by substrate mass); 45 °C), an experimental design (2(3)) was conducted to evaluate the effects of the following parameters: alcohol to oil molar ratios, reaction time and temperature...
March 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28452738/development-of-lc-ms-ms-method-for-determination-of-the-olanzapine-in-human-plasma
#4
K Sivsivadze, M Jokhadze, P Tushurashvili, T Murtazashvili, N Imnadze
The study aim was to develop a validated selective, reproducible and sensitive Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) method for qualitative and quantitative determination of olanzapin (OLZ ) in human plasma. For isolation was used solid phase extraction with the Gilson GX-271 ASPEC Solid phase extraction system, cartridge Supelclean LC-18 SPE 500mg. Elution solvent contained 40mL of isopropanol, 4mL of concentrated ammonium hydroxide and 156mL of freshly prepared methylene chloride. Samples containing OLZ and IS were chromatographed on AGILENT TECHNOLOGIES 1290 Infinity AGILENT TECHNOLOGIES 6460 Triple quad LC-MS/MS system...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28335440/profile-of-polyphenol-compounds-of-five-muscadine-grapes-cultivated-in-the-united-states-and-in-newly-adapted-locations-in-china
#5
Zheng Wei, Jianming Luo, Yu Huang, Wenfeng Guo, Yali Zhang, Huan Guan, Changmou Xu, Jiang Lu
Polyphenol compositions and concentrations in skins and seeds of five muscadine grapes (cv. "Noble", "Alachua", "Carlos", "Fry", and "Granny Val") cultivated in the United States (Tallahassee-Florida, TA-FL) and South China (Nanning-Guangxi, NN-GX and Pu'er-Yunnan, PE-YN) were investigated, using ultra performance liquid chromatography tandem triple quadrupole time-of-flight mass spectrometry (UPLC Triple TOF MS/MS). Fourteen ellagitannins were newly identified in these muscadine grapes. The grapes grown in NN-GX accumulated higher levels of ellagic acid, methyl brevifolin carboxylate, and ellagic acid glucoside in skins, and penta-O-galloyl-glucose in seeds...
March 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28300877/mast-cell-concentration-and-skin-wound-contraction-in-rats-treated-with-ximenia-americana-l
#6
José de Castro Souza Junior Neto, Lígia Reis de Moura Estevão, Liriane Baratella-Evêncio, Marcela Gabriela Feitosa Vieira, Ricardo Santos Simões, Rinaldo Florencio-Silva, Luís Evêncio-Luz, Joaquim Evêncio-Neto
PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. METHODS: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia americana), GP (wounds that received vehicle), and GC (wounds without product application)...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28273352/multifactorial-study-and-kinetics-of-signal-development-in-ferrous-methylthymol-blue-gelatin-gel-dosimeters
#7
Kalin I Penev, Kibret Mequanint
PURPOSE: To develop and characterize a ferrous-methylthymol blue-gelatin gel dosimeter with low optical background and appropriate additives for reduced rate of auto-oxidation and diffusion. METHODS: A mixed-level multifactorial design of experiments was used to test the effects of the concentrations of sulfuric acid, 5-nitro-1,10-phenanthroline (Nn), and glyoxal (Gx) on the background absorbance, dose sensitivity, and auto-oxidation of the tested gel dosimeter...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28260382/fast-separation-and-sensitive-quantitation-of-polymethoxylated-flavonoids-in-the-peels-of-citrus-using-uplc-q-tof-ms
#8
Tian Tian Xing, Xi Juan Zhao, Yi Dan Zhang, Yuan Fang Li
A rapid, sensitive, and efficient ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) method has been developed to analyze polymethoxylated flavonoids (PMFs) in 14 Citrus peels, including 7 Citrus reticulata (C. reticulata) and 7 Citrus sinensis (C. sinensis). In this study, fast separation can be achieved within 12 min and 42 PMFs have been identified including 33 flavones and 9 flavanones. Most C. reticulata were shown to contain more than 20 PMFs, except Guangxihongpisuanju (GX) containing only 12 PMFs, while most C...
March 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28252967/hyperfine-sublevel-correlation-spectroscopy-studies-of-iron-sulfur-cluster-in-rieske-protein-from-green-sulfur-bacterium-chlorobaculum-tepidum
#9
Hiroki Nagashima, Hiraku Kishimoto, Risa Mutoh, Naotaka Terashima, Hirozo Oh-Oka, Genji Kurisu, Hiroyuki Mino
The magnetic properties of the Rieske protein purified from Chlorobaculum tepidum were investigated using electron paramagnetic resonance and hyperfine sublevel correlation spectroscopy (HYSCORE). The g-values of the Fe2S2 center were gx = 1.81, gy = 1.90, and gz = 2.03. Four classes of nitrogen signals were obtained by HYSCORE. Nitrogens 1 and 2 had relatively strong magnetic hyperfine couplings and were assigned as the nitrogen directly ligated to Fe. Nitrogens 3 and 4 had relatively weak magnetic hyperfine couplings and were assigned as the other nitrogen of the His ligands and peptide nitrogen connected to the sulfur atom via hydrogen bonding, respectively...
March 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28093423/medical-and-psychosocial-factors-associated-with-antibiotic-prescribing-in-primary-care-survey-questionnaire-and-factor-analysis
#10
Tau-Hong Lee, Joshua Gx Wong, David Cb Lye, Mark Ic Chen, Victor Wk Loh, Yee-Sin Leo, Linda K Lee, Angela Lp Chow
BACKGROUND: Acute upper respiratory infections (AURI) are the leading causes of antibiotic prescribing in primary care although antibiotics are often not indicated. AIM: To gain an understanding of the knowledge, attitudes, and practices (KAP) of GPs in Singapore and the associated latent factors to guide the implementation of an effective programme to reduce antibiotic use in primary care. DESIGN AND SETTING: An anonymous survey on the KAP of antibiotic use in AURI of GPs in Singapore...
March 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28081476/electron-spin-relaxation-of-a-boron-containing-heterocyclic-radical
#11
Sandra S Eaton, Kirby Huber, Hanan Elajaili, Joseph McPeak, Gareth R Eaton, Lauren E Longobardi, Douglas W Stephan
Preparation of the stable boron-containing heterocyclic phenanthrenedione radical, (C6F5)2B(O2C14H8), by frustrated Lewis pair chemistry has been reported recently. Electron paramagnetic resonance measurements of this radical were made at X-band in toluene:dichloromethane (9:1) from 10 to 293K, in toluene from 180 to 293K and at Q-band at 80K. In well-deoxygenated 0.1mM toluene solution at room temperature hyperfine splittings from (11)B, four pairs of (1)H, and 5 pairs of (19)F contribute to an EPR spectrum with many resolved lines...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28028556/effect-of-intravenous-gadoxetate-disodium-and-flip-angle-on-hepatic-proton-density-fat-fraction-estimation-with-six-echo-gradient-recalled-echo-magnitude-based-mr-imaging-at-3t
#12
Charlie C Park, Gavin Hamilton, Ajinkya Desai, Kevin A Zand, Tanya Wolfson, Jonathan C Hooker, Eduardo Costa, Elhamy Heba, Lisa Clark, Anthony Gamst, Rohit Loomba, Michael S Middleton, Claude B Sirlin
PURPOSE: The aim of the study was to determine in patients undergoing gadoxetate disodium (Gx)-enhanced MR exams whether proton density fat fraction (PDFF) estimation accuracy of magnitude-based multi-gradient-echo MRI (MRI-M) could be improved by using high flip angle (FA) on post-contrast images. MATERIALS AND METHODS: Thirty-one adults with known or suspected hepatic steatosis undergoing 3T clinical Gx-enhanced liver MRI were enrolled prospectively. MR spectroscopy (MRS), the reference standard, was performed before Gx to measure MRS-PDFF...
December 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27995869/evaluation-of-xpert-mrsa-gen-3-and-bd-max-mrsa-xt-for-meticillin-resistant-staphylococcusaureus-screening-in-a-routine-diagnostic-setting-in-a-low-prevalence-area
#13
Xiaohui Chen Nielsen, Tina Vasehus Madsen, Jørgen Engberg
Screening and pre-emptive isolation of at-risk patients are important aspects of the Danish approach to the prevention of meticillin-resistant Staphylococcusaureus (MRSA) infection, but screening with conventional culture can take up to 3 days for results to become available with attendant costs and disadvantages of prolonged isolation. We sought to evaluate the accuracy, time to availability of results and potential economic benefits of two next-generation MRSA screening assays, Xpert MRSA Gen 3 (GX MRSA) and BD MAX MRSA XT, in a setting of a consolidated laboratory serving a number of hospitals with a low prevalence of MRSA and using enrichment culture as a reference method...
January 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27957647/dosimetry-in-micro-computed-tomography-a-review-of-the-measurement-methods-impacts-and-characterization-of-the-quantum-gx-imaging-system
#14
Jeffrey A Meganck, Bob Liu
PURPOSE: X-ray micro-computed tomography (μCT) is a widely used imaging modality in preclinical research with applications in many areas including orthopedics, pulmonology, oncology, cardiology, and infectious disease. X-rays are a form of ionizing radiation and, therefore, can potentially induce damage and cause detrimental effects. Previous reviews have touched on these effects but have not comprehensively covered the possible implications on study results. Furthermore, interpreting data across these studies is difficult because there is no widely accepted dose characterization methodology for preclinical μCT...
December 12, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27936002/the-significance-of-prolonged-and-saddleback-fever-in-hospitalised-adult-dengue
#15
Deborah Hl Ng, Joshua Gx Wong, Tun-Linn Thein, Yee-Sin Leo, David C Lye
Dengue fever is gaining importance in Singapore with an increase in the number of cases and mortality in recent years. Although prolonged and saddleback fever have been reported in dengue fever, there are no specific studies on their significance in dengue. This study aims to examine the prevalence of prolonged and saddleback fever in dengue as well as their associations with dengue severity. A total of 2843 polymerase-chain reaction (PCR) confirmed dengue patients admitted to Tan Tock Seng Hospital from 2004 to 2008 were included in the study...
2016: PloS One
https://www.readbyqxmd.com/read/27900175/free-fall-acrobatics-to-reduce-neck-loads-during-parachute-opening-shock-evaluation-of-an-intervention-acropose
#16
Anton Westman, Björn O Äng
INTRODUCTION: Neck pain is a widespread health problem in the skydiver athlete population, epidemiologically linked to repeated exposure to parachute opening shock (POS). During POS, a parachutist is subjected to considerable deceleration forces. This study aims to evaluate the use of preventive free fall acrobatics to reduce the biomechanical load on the neck of parachutists during parachute opening. METHODS AND ANALYSIS: Interventional study with a cross-over, within-subject, repeated measures design...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27879019/screening-for-alk-abnormalities-in-central-nervous-system-metastases-of-non-small-cell-lung-cancer-alk-abnormalities-in-cns-metastases-of-nsclc
#17
Marcin Nicoś, Bożena Jarosz, Paweł Krawczyk, Kamila Wojas-Krawczyk, Tomasz Kucharczyk, Marek Sawicki, Juliusz Pankowski, Tomasz Trojanowski, Janusz Milanowski
Anaplastic lymphoma kinase (ALK) gene rearrangement was reported in 3-7% of primary non-small-cell lung cancer (NSCLC) and its presence is commonly associated with adenocarcinoma (AD) type and non-smoking history. ALK tyrosine kinase inhibitors (TKIs) such as crizotinib, alectinib and ceritinib showed efficiency in patients with primary NSCLC harboring ALK gene rearrangement. Moreover, response to ALK TKIs was observed in central nervous system (CNS) metastatic lesions of NSCLC. However, there are no reports concerning the frequency of ALK rearrangement in CNS metastases...
November 23, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27824867/microrna-expression-patterns-of-cd8-t-cells-in-acute-and-chronic-brucellosis
#18
Ferah Budak, S Haldun Bal, Gulcin Tezcan, Furkan Guvenc, E Halis Akalin, Guher Goral, Gunnur Deniz, H Barbaros Oral
Although our knowledge about Brucella virulence factors and the host response increase rapidly, the mechanisms of immune evasion by the pathogen and causes of chronic disease are still unknown. Here, we aimed to investigate the immunological factors which belong to CD8+ T cells and their roles in the transition of brucellosis from acute to chronic infection. Using miRNA microarray, more than 2000 miRNAs were screened in CD8+ T cells of patients with acute or chronic brucellosis and healthy controls that were sorted from peripheral blood with flow cytometry and validated through qRT-PCR...
2016: PloS One
https://www.readbyqxmd.com/read/27802032/uncovering-the-role-of-oxygen-atom-transfer-in-ru-based-catalytic-water-oxidation
#19
Dooshaye Moonshiram, Yuliana Pineda-Galvan, Darren Erdman, Mark Palenik, Ruifa Zong, Randolph Thummel, Yulia Pushkar
The realization of artificial photosynthesis carries the promise of cheap and abundant energy, however, significant advances in the rational design of water oxidation catalysts are required. Detailed information on the structure of the catalyst under reaction conditions and mechanisms of O-O bond formation should be obtained. Here, we used a combination of electron paramagnetic resonance (EPR), stopped flow freeze quench on a millisecond-second time scale, X-ray absorption (XAS), resonance Raman (RR) spectroscopy, and density functional theory (DFT) to follow the dynamics of the Ru-based single site catalyst, [Ru(II)(NPM)(4-pic)2(H2O)](2+) (NPM = 4-t-butyl-2,6-di(1',8'-naphthyrid-2'-yl)pyridine, pic = 4-picoline), under the water oxidation conditions...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27722424/determination-of-physical-emulsion-stabilization-mechanisms-of-wood-hemicelluloses-via-rheological-and-interfacial-characterization
#20
K S Mikkonen, D Merger, P Kilpeläinen, L Murtomäki, U S Schmidt, M Wilhelm
Materials manufacturing industries seek efficient, economic, and sustainable compounds for stabilizing dispersed systems such as emulsions. In this study, novel, abundant biobased hydrocolloids spruce galactoglucomannans (GGM) and birch glucuronoxylans (GX) were obtained from a forestry biorefining process and characterized as versatile stabilizers of rapeseed oil-in-water emulsions. For the first time, GGM and GX isolated by pressurized hot water extraction (PHWE) of spruce and birch saw meal, respectively, were studied in emulsions...
September 27, 2016: Soft Matter
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