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https://www.readbyqxmd.com/read/29351264/identification-of-cyclic-dipeptides-from-escherichia-coli-as-new-antimicrobial-agents-against-ralstonia-solanacearum
#1
Shihao Song, Shuna Fu, Xiuyun Sun, Peng Li, Ji'en Wu, Tingyan Dong, Fei He, Yinyue Deng
Ralstonia solanacearum is a causative agent of bacterial wilt in many important crops throughout the world. How to control bacterial wilt caused by R. solanacearum is a major problem in agriculture. In this study, we aim to isolate the biocontrol agents that have high efficacy in the control of bacterial wilt. Three new bacterial strains with high antimicrobial activity against R. solanacearum GMI1000 were isolated and identified. Our results demonstrated that these bacteria could remarkably inhibit the disease index of host plant infected by R...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29330041/acute-epileptiform-activity-induced-by-gabazine-involves-proteasomal-rather-than-lysosomal-degradation-of-kca2-2-channels
#2
Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute in vitro epilepsy model induced in hippocampal brain slice preparations by exposure to the GABAA receptor blocker gabazine (GZ), the AHP was previously shown to be significantly decreased. Here, we asked the question whether KCa2...
January 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29315360/cgmanalyzer-an-r-package-for-analyzing-continuous-glucose-monitoring-studies
#3
Xiaohua Douglas Zhang, Zhaozhi Zhang, Dandan Wang
Summary: The R package CGManalyzer contains functions for analyzing data from a continuous glucose monitoring (CGM) study. It covers a wide and comprehensive range of data analysis methods including reading a series of datasets, obtaining summary statistics of glucose levels, plotting data, transforming the time stamp format, fixing missing values, evaluating the mean of daily difference (MODD) and continuous overlapping net glycemic action (CONGA), calculating multiscale sample entropy (MSE), conducting pairwise comparison, displaying results using various plots including a new type of plot called an antenna plot, etc...
January 5, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29218103/microrna-429-sensitizes-pancreatic-cancer-cells-to-gemcitabine-through-regulation-of-pdcd4
#4
Gang Yu, Benli Jia, Yunsheng Cheng, Lianbang Zhou, Bo Qian, Zhining Liu, Yong Wang
One of the features for pancreatic cancer is that it is often resistant to chemotherapy treatment, which is one of the major hindrances in the treatment of this malignancy. Previous studies indicated that the microRNAs (miRNAs) could mediate resistance of tumor cells to chemotherapy drug in the cancer progression. In the present study, we are aimed to examine whether microRNA-429 was involved in mediating the chemo-resistance of pancreatic cancer cells to gemcitabine. Firstly, a gemcitabine-resistant pancreatic cancer cell line (SW1990/GZ) derived from cell line (SW1990) was constructed and found to possess a decreased expression of miR-429 when it is compared to the original cell line...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29188551/molecular-characterization-of-fmr1-gene-by-tp-pcr-in-women-of-reproductive-age-and-women-with-premature-ovarian-insufficiency
#5
Deepika Delsa Dean, Sarita Agarwal, Deepa Kapoor, Kuldeep Singh, Chandra Vati
BACKGROUND: Fragile X syndrome is caused by CGG repeat expansion mutation in the FMR1 gene. Normal alleles have 5-44 CGG repeats with AGG interruptions. The expanded gray zone (GZ) (45-54 repeats) and premutation (PM) (55-200 repeats) alleles are often uninterrupted and are unstably inherited in subsequent generations. The prevalence of PM and GZ carriers is high in the female population, at 1/66 and 1/113, respectively, and PM is associated with fertility problems in 20% of cases. OBJECTIVE: Our objective was to molecularly characterize CGG repeats and AGG interruption sequences in the FMR1 gene in women of reproductive age and in women with premature ovarian insufficiency (POI)...
November 29, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29168858/ferromagnetic-coupling-in-copper-benzimidazole-chloride-structural-mass-spectrometry-magnetism-and-dft-studies
#6
Xing-Xing Shi, Yuexing Zhang, Qiu-Jie Chen, Zheng Yin, Xue-Li Chen, Zhenxing Wang, Zhong-Wen Ouyang, Mohamedally Kurmoo, Ming-Hua Zeng
Herein, quasi-square planar Cu(II)(Hmbm)Cl2 (CBC, Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol) was arranged in a pseudo orthogonal way to form Cl-bridged chains, and further ππ interactions resulted in distorted hexagonal layers. DFT calculations reveal a bond strength order of Cu-Cl > Cu-O/N ≫ CuCl. ESI-MS data reveal several small fragments from CBC, but oligomeric [Cu], [Cu], and [Cu] for non-zero in-source energies; MS data indicates the occurrence of several chemical processes, viz. splitting of the ligand, oligomerization, and redox reaction of alcohol to aldehyde and Cu(II) to Cu(I)...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29157342/molecular-biological-effects-of-weightlessness-and-hypergravity-on-intervertebral-disc-degeneration
#7
Di Wu, Chao Zheng, Ji Wu, Rongrong Huang, Xuanyu Chen, Tong Zhang, Lili Zhang
INTRODUCTION: The rate of intervertebral disc degeneration (IVDD) is influenced by environmental factors. Extracellular matrix (ECM) destruction and apoptosis of intervertebral disc cells are major characteristics of IVDD. ECM degradation is closely linked to up-regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMP). This study aimed to elucidate the molecular biological changes during IVDD under conditions of weightlessness and hypergravity. METHODS: A total of 120 rabbits were divided randomly into four groups: control group, weightlessness group, hypergravity group, and mixed (hypergravity + weightlessness) group...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29119984/catalytic-fixation-of-atmospheric-carbon-dioxide-by-copper-ii-complexes-of-bidentate-ligands
#8
Sethuraman Muthuramalingam, Themmila Khamrang, Marappan Velusamy, Ramasamy Mayilmurugan
New copper(ii) complexes, [Cu(L1)2(H2O)](ClO4)2, 1 [L1 = 2-pyridin-2-yl-quinoline], [Cu(L2)2(H2O)](ClO4)2, 2 [L2 = 2-pyridin-2-yl-quinoxaline], [Cu(L3)2(H2O)](ClO4)2, 3 [L3 = 6,7-dimethyl-2-pyridin-2-yl-quinoxaline], [Cu(L4)2(H2O)](ClO4)2, 4 [L4 = 4-phenyl-2-pyridin-2-yl-quinoline] and [Cu(L5)2(H2O)](ClO4)2, 5 [L5 = 4-phenyl-2-pyridin-2-yl-quinazoline], were synthesized and characterized as catalysts for selective fixation of atmospheric CO2. The molecular structure of 2 was determined by single-crystal X-ray studies and shown to have an unusual trigonal bipyramid geometry (τ, 0...
November 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29089040/veritable-antiviral-capacity-of-natural-killer-cells-in-chronic-hbv-infection-an-argument-for-an-earlier-anti-virus-treatment
#9
Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian, Yuehua Huang
BACKGROUND: There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK cell immunity. METHODS: A total of 237 eligible CHB patients and 22 healthy controls were enrolled in our study. Demographic and clinical data were collected, and the CHB phases (immune active-IA, immune tolerant phase-IT, inactive CHB-IC, and grey zone-GZ) were classified according to the latest American Association for the Study of Liver Disease guidelines...
October 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29046181/instrument-failure-stress-and-spatial-disorientation-leading-to-a-fatal-crash-with-a-large-aircraft
#10
Arne Tribukait, Ola Eiken
BACKGROUND: An aircraft's orientation relative to the ground cannot be perceived via the sense of balance or the somatosensory system. When devoid of external visual references, the pilot must rely on instruments. A sudden unexpected instrument indication is a challenge to the pilot, who might have to question the instrument instead of responding with the controls. In this case report we analyze, from a human-factors perspective, how a limited instrument failure led to a fatal accident...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29046179/coping-and-changes-in-arousal-after-exposure-to-gz-load
#11
Marcin Piotr Biernacki, Rafal Lewkowicz, Piotr Zieliński, Mieczyslaw Wojtkowiak
BACKGROUND: Acceleration load causes several physiological changes that play important roles in pilot performance. One of the problems is determining individual factors responsible for the differences in changes in the level of central nervous system (CNS) arousal after exposure to acceleration loads. We were interested in whether the coping style and anxiety as a trait might differentiate the subjects in terms of reactions of the CNS to +Gz load-related stress. METHODS: Examined were 31 male volunteers with ages between 23 and 30 yr...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29046176/dysrhythmias-in-laypersons-during-centrifuge-simulated-suborbital-spaceflight
#12
Rahul Suresh, Rebecca S Blue, Charles H Mathers, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: There are limited data on cardiac dysrhythmias in laypersons during hypergravity exposure. We report layperson electrocardiograph (ECG) findings and tolerance of dysrhythmias during centrifuge-simulated suborbital spaceflight. METHODS: Volunteers participated in varied-length centrifuge training programs of 2-7 centrifuge runs over 0.5-2 d, culminating in two simulated suborbital spaceflights of combined +Gz and +Gx (peak +4.0 Gz, +6.0 Gx, duration 5 s)...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29046175/risk-factors-for-cervical-pain-in-f-15c-pilots
#13
Eric M Chumbley, Adrienne Stolfi, James C McEachen
INTRODUCTION: Many fighter pilots report cervical pain during their careers. Etiology likely relates to +Gz exposure, physical positioning with maneuvers, and varying load associated with headgear. We evaluated whether selected risk factors predicted cervical pain in this population. METHODS: An Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant, controlled crossover study of the use of home cervical traction was undertaken with 20 male F-15C pilots...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28952860/sport-for-adults-aged-50-years-participation-benefits-and-barriers
#14
Claire R Jenkin, Rochelle M Eime, Hans Westerbeek, Jannique Gz van Uffelen
Despite the health benefits of sport, the proportion of people participating in sport decreases with age. This qualitative study explored the benefits and barriers regarding older adult community sport participation, from the perspective of National Sporting Organizations, in addition to older adult sport club and non-sport club members, across eight focus group interviews (n = 49). Seven benefits were discussed, primarily social and physical health and intergenerational opportunities. Ten barriers were also discussed, including physical health, time constraints and lack of appropriate playing opportunities...
September 27, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28933714/hr-%C3%AC-v-775-o-8322-and-rpe-relationships-in-an-aquatic-incremental-maximum-test-performed-by-young-women
#15
Gabriela B David, Luana S Andrade, Gustavo Z Schaun, Cristine L Alberton
David, GB, Andrade, LS, Schaun, GZ, and Alberton, CL. HR, V̇O₂, and RPE relationships in an aquatic incremental maximum test performed by young women. J Strength Cond Res 31(10): 2852-2858, 2017-The purpose of the study was to verify the relationship between oxygen uptake (V̇O₂), heart rate (HR), rate of perceived exertion (RPE), and cadence (CAD) in an aquatic incremental maximum test performed during a water-based stationary running exercise. The study also verified the best adjustments for these relationships (linear or polynomial)...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28931073/bacterial-and-diazotrophic-diversities-of-endophytes-in-dendrobium-catenatum-determined-through-barcoded-pyrosequencing
#16
Ou Li, Rong Xiao, Lihua Sun, Chenglin Guan, Dedong Kong, Xiufang Hu
As an epiphyte orchid, Dendrobium catenatum relies on microorganisms for requisite nutrients. Metagenome pyrosequencing based on 16S rRNA and nifH genes was used to characterize the bacterial and diazotrophic communities associated with D. catenatum collected from 5 districts in China. Based on Meta-16S rRNA sequencing, 22 bacterial phyla and 699 genera were identified, distributed as 125 genera from 8 phyla and 319 genera from 10 phyla shared by all the planting bases and all the tissues, respectively. The predominant Proteobacteria varied from 71...
2017: PloS One
https://www.readbyqxmd.com/read/28875542/analysis-on-the-local-structures-for-3d-1-impurities-ti-3-and-v-4-in-ktipo4
#17
C C Ding, S Y Wu, L J Zhang, Y Q Xu, Z H Zhang, M H Wu, B H Teng
Making use of the perturbation formulae for 3d(1) ions (Ti(3+) and V(4+) ) under orthorhombically compressed octahedra, the spin Hamiltonian parameters (SHPs) (g factors: gx , gy , gz and hyperfine structure constants: Ax , Ay , Az ) and local structures of the 3d(1) impurity centres C1 , C2 and C3 in KTP crystals are theoretically analyzed in a consistent way. The remarkable local distortions (i.e., the relative axial compression ratios 11.2%, 7.0% and 5.5% along Z axis and the relative planar bond length variation ratios 15...
September 6, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28863003/varenicline-and-gz-793a-differentially-decrease-methamphetamine-self-administration-under-a-multiple-schedule-of-reinforcement-in-rats
#18
Megan M Kangiser, Linda P Dwoskin, Guangrong Zheng, Peter A Crooks, Dustin J Stairs
Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction. Ideally, a pharmacotherapy should selectively decrease methamphetamine self-administration without affecting responding for other reinforcers. One way to test this is with the use of a multiple schedule of reinforcement, in which drug and food are available in alternating components within a session. The present study evaluated GZ-793A, a vesicular monoamine transporter-2 inhibitor, and varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic acetylcholine receptors, for their ability to decrease methamphetamine and food self-administration using a multiple schedule of reinforcement...
August 31, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28800146/the-relationship-between-open-versus-normal-contact-point-and-inter-proximal-papilla-dimensions-in-periodontally-healthy-young-adults-a-controlled-clinical-trial
#19
Ronaldo Barcellos de Santana, Jose Luis Carneiro de Miranda, Carolina Miller Mattos de Santana
AIM: The gingival architecture is determined by the spatial orientation of the gingival zenith (GZ) and the inter-dental papillae (IP). Among the factors commonly associated with the presence and morphology of the IP, the contact point (CP) and the inter-dental distance relationships have been considered the most important. The objective of the present controlled clinical trial was to evaluate the role of the CP in determining the clinical and morphometric parameters of the inter-dental papilla...
November 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28755076/comparative-pharmacokinetics-of-three-phenylpropanoids-in-rat-plasma-after-oral-administration-of-ramulus-cinnamomi-and-ramulus-cinnamomi-ephedrae-herba-herb-couple-extract
#20
Ping Wei, Qing-Fa Tang, Hui-Ling Huo, Fei-Long Chen, Shuai Song, Xue-Feng Xing, Jia-Bo Luo
OBJECTIVE: To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH). METHODS: Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study...
July 28, 2017: Chinese Journal of Integrative Medicine
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