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https://www.readbyqxmd.com/read/28323584/evidence-for-gz-adaptation-observed-with-wearable-biosensors-during-high-performance-jet-flight
#1
G Merrill Rice, Dallas Snider, Jeffrey L Moore, J Timothy Lavan, Rich Folga, Thomas B VanBrunt
INTRODUCTION: Few studies have evaluated physiological responses to high acceleration forces during actual flight and to our knowledge no normative data has been acquired by technologies such as wearable biosensors during high performance jet aircraft operations. METHODS: In-flight physiological data from an FDA cleared portable triaxial accelerometer and bio-sensor were observed from five active duty F-18 pilots of the Naval Flight Demonstration Squadron (Blue Angels)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28301141/reconstitution-and-substrate-specificity-of-the-radical-sam-thiazole-c-methyltransferase-in-thiomuracin-biosynthesis
#2
Nilkamal Mahanta, Zhengan Zhang, Graham A Hudson, Wilfred A van der Donk, Douglas A Mitchell
Thiomuracin is a thiopeptide antibiotic with potent activity towards Gram-positive drug-resistant bacteria. Thiomuracin is biosynthesized from a precursor peptide, TbtA, by a complex array of posttranslational modifications. One of several intriguing transformations is the C-methylation of thiazole, occurring at an unactivated sp2 carbon. Herein, we report the in vitro reconstitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which catalyzes the formation of 5-methylthiazole at a single site...
March 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28289129/helios-expression-coordinates-the-development-of-a-subset-of-striatopallidal-medium-spiny-neurons
#3
Raquel Martín-Ibáñez, Mónica Pardo, Albert Giralt, Andrés Miguez, Inés Guardia, Lucile Marion-Poll, Cristina Herranz, Miriam Esgleas, Gerardo Garcia-Díaz Barriga, Michael J Edel, Carlos Vicario-Abejón, Jordi Alberch, Jean-Antoine Girault, Susan Chan, Philippe Kastner, Josep M Canals
Here we unravel the mechanism of action of Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons that express dopamine 2 receptor (D2R) and enkephalin (ENK). To exert this effect He is expressed in neural progenitor cells (NPCs) retaining them into the G1/G0 phase of the cell cycle. Thus, the lack of He produces an increase of S-phase entry and S-phase length of NPCs which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ) that end up dying at postnatal stages...
March 13, 2017: Development
https://www.readbyqxmd.com/read/28274441/preparation-of-glycosylated-zein-and-retarding-effect-on-lipid-oxidation-of-ground-pork
#4
Xiao-Jie Wang, Xi-Qun Zheng, Xiao-Lan Liu, Narasimha-Kumar Kopparapu, Wan-Suo Cong, Yong-Ping Deng
The focus of the present work was to investigate the glycosylation of zein, partial properties of the glycosylated zein (GZ) and its retarding effect on lipid oxidation of ground pork. Zein was glycosylated with chitosan (MW 1500Da) by microbial transglutaminase, the reaction was verified by FT-IR. Under the optimized conditions, 97.48mg of glucosamine was covalently conjugated to 1g of zein, determined by HPLC. The solubility and the surface hydrophobicity of GZ were significantly improved. In vitro studies of GZ showed a dose-dependent scavenging activity against free radicals of DPPH, superoxide and hydroxyl radical, and the EC50 value for DPPH radical was 1...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28271884/electrostatic-potential-determined-magnetic-dynamics-observed-in-two-mononuclear-%C3%AE-diketone-dysprosium-iii-single-molecule-magnets
#5
Pei-Pei Cen, Sheng Zhang, Xiang-Yu Liu, Wei-Ming Song, Yi-Quan Zhang, Gang Xie, San-Ping Chen
Two β-diketone mononuclear Dy(III) compounds, formulated as Dy(BTFA)3(H2O)2 (1) and Dy(BTFA)3(bpy) (2) (BTFA = 3-benzoyl-1,1,1-trifluoroacetone, bpy = 2,2'-bipyridine), were prepared. Compound 1 can be identified to transform to 2 in the attendance of bpy coligand, when the local geometry symmetry of eight-coordinated Dy(III) ion changes from a dodecahedron (D2d) in 1 to a square antiprism (D4d) in 2. Fine-tuning structure aroused by auxiliary ligand has dramatical impact on magnetic properties of compounds 1 and 2...
March 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28268313/alterations-in-cardiovascular-system-under-artificially-simulated-microgravity-preliminary-study
#6
Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova
The main goal of this work is to study the alterations occurred in human cardiovascular system under artificially simulated microgravity by using special short-arm centrifuge. We have used arterial blood pressure, ankle-brachial pressure index and accelerated photoplethysmography approach to determine the effects of artificially simulated microgravity on vascular system. The group of 30 healthy male volunteers was studied in a short-arm human centrifuge at two levels of gravity gradients along head-to-foot direction (Gz): normal gravity gradient of 1 Gz and so called microgravity mode of 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28252967/hyperfine-sublevel-correlation-spectroscopy-studies-of-iron-sulfur-cluster-in-rieske-protein-from-green-sulfur-bacterium-chlorobaculum-tepidum
#7
Hiroki Nagashima, Hiraku Kishimoto, Risa Mutoh, Naotaka Terashima, Hirozo Oh-Oka, Genji Kurisu, Hiroyuki Mino
The magnetic properties of the Rieske protein purified from Chlorobaculum tepidum were investigated using electron paramagnetic resonance and hyperfine sublevel correlation spectroscopy (HYSCORE). The g-values of the Fe2S2 center were gx = 1.81, gy = 1.90, and gz = 2.03. Four classes of nitrogen signals were obtained by HYSCORE. Nitrogens 1 and 2 had relatively strong magnetic hyperfine couplings and were assigned as the nitrogen directly ligated to Fe. Nitrogens 3 and 4 had relatively weak magnetic hyperfine couplings and were assigned as the other nitrogen of the His ligands and peptide nitrogen connected to the sulfur atom via hydrogen bonding, respectively...
March 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28226473/alterations-in-cardiovascular-system-under-artificially-simulated-microgravity-preliminary-study
#8
Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova, Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova, Aleksandr A Fedotov, Anna S Akulova, Sergey A Akulov
The main goal of this work is to study the alterations occurred in human cardiovascular system under artificially simulated microgravity by using special short-arm centrifuge. We have used arterial blood pressure, ankle-brachial pressure index and accelerated photoplethysmography approach to determine the effects of artificially simulated microgravity on vascular system. The group of 30 healthy male volunteers was studied in a short-arm human centrifuge at two levels of gravity gradients along head-to-foot direction (Gz): normal gravity gradient of 1 Gz and so called microgravity mode of 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28163357/tube-side-mass-transfer-for-hollow-fibre-membrane-contactors-operated-in-the-low-graetz-range
#9
C Y Wang, E Mercer, F Kamranvand, L Williams, A Kolios, A Parker, S Tyrrel, E Cartmell, E J McAdam
Transformation of the tube-side mass transfer coefficient derived in hollow fibre membrane contactors (HFMC) of different characteristic length scales (equivalent diameter and fibre length) has been studied when operated in the low Graetz range (Gz<10). Within the low Gz range, mass transfer is generally described by the Graetz problem (Sh=3.67) which assumes that the concentration profile comprises a constant shape over the fibre radius. In this study, it is experimentally evidenced that this assumption over predicts mass transfer within the low Graetz range...
February 1, 2017: Journal of Membrane Science
https://www.readbyqxmd.com/read/28130775/delphiforce-a-tool-for-electrostatic-force-calculations-applications-to-macromolecular-binding
#10
Lin Li, Arghya Chakravorty, Emil Alexov
Long-range electrostatic forces play an important role in molecular biology, particularly in macromolecular interactions. However, calculating the electrostatic forces for irregularly shaped molecules immersed in water is a difficult task. Here, we report a new tool, DelPhiForce, which is a tool in the DelPhi package that calculates and visualizes the electrostatic forces in biomolecular systems. In parallel, the DelPhi algorithm for modeling electrostatic potential at user-defined positions has been enhanced to include triquadratic and tricubic interpolation methods...
April 5, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28103202/erratum-for-the-paper-cytology-of-pericardial-effusion-due-to-malignancy-kalogeraki-a-lazopoulos-g-papadakis-gz-tamiolakis-d-karvela-kalogeraki-i-karvelas-kalogerakis-m-segredakis-j-papadakis-m-moustou-e-datseri-g-chalkiadakis-ge-tzardi-m-rom-j-intern-med-2016
#11
https://www.readbyqxmd.com/read/28095952/neck-and-shoulder-muscle-activation-among-experienced-and-inexperienced-pilots-in-gz-exposure
#12
Tuomas Honkanen, Juha Oksa, Matti J Mäntysaari, Heikki Kyröläinen, Janne Avela
BACKGROUND: The aim of the present study was to compare differences in electromyography (EMG) activation of the neck and shoulder muscles between groups of inexperienced and experienced pilots during controlled +Gz exposure in a centrifuge. METHODS: The subjects were volunteer cadets (inexperienced group) and lieutenants (experienced group) undergoing their first centrifuge training. The first group did not have any high performance aircraft (HPA) experience, while the latter one had a 1-yr experience of intense flying of HPA...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28081476/electron-spin-relaxation-of-a-boron-containing-heterocyclic-radical
#13
Sandra S Eaton, Kirby Huber, Hanan Elajaili, Joseph McPeak, Gareth R Eaton, Lauren E Longobardi, Douglas W Stephan
Preparation of the stable boron-containing heterocyclic phenanthrenedione radical, (C6F5)2B(O2C14H8), by frustrated Lewis pair chemistry has been reported recently. Electron paramagnetic resonance measurements of this radical were made at X-band in toluene:dichloromethane (9:1) from 10 to 293K, in toluene from 180 to 293K and at Q-band at 80K. In well-deoxygenated 0.1mM toluene solution at room temperature hyperfine splittings from (11)B, four pairs of (1)H, and 5 pairs of (19)F contribute to an EPR spectrum with many resolved lines...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27986625/gz-793a-inhibits-the-neurochemical-effects-of-methamphetamine-via-a-selective-interaction-with-the-vesicular-monoamine-transporter-2
#14
Justin R Nickell, Kiran B Siripurapu, David B Horton, Guangrong Zheng, Peter A Crooks, Linda P Dwoskin
Lobeline and lobelane inhibit the behavioral and neurochemical effects of methamphetamine via an interaction with the vesicular monoamine transporter-2 (VMAT2). However, lobeline has high affinity for nicotinic receptors, and tolerance develops to the behavioral effects of lobelane. A water-soluble analog of lobelane, R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxyphenethyl)piperidine hydrochloride (GZ-793A), also interacts selectively with VMAT2 to inhibit the effects of methamphetamine, but does not produce behavioral tolerance...
December 13, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27934923/timosaponin-aiii-induces-antiplatelet-and-antithrombotic-activity-via-gq-mediated-signaling-by-the-thromboxane-a2-receptor
#15
Yue Cong, Limei Wang, Renjun Peng, Yang Zhao, Fan Bai, Chao Yang, Xiaolan Liu, Daqian Wang, Baiping Ma, Yuwen Cong
The thromboxane (Tx) A2 pathway is a major contributor to the amplification of initial platelet activation and is therefore a key drug target. To identify potent small-molecule inhibitors of the thromboxane prostaglandin (TP) receptor, we screened a small steroidal saponin library using U46619-induced rat platelet aggregation assays. Timosaponin AIII (TAIII) was identified as a potent inhibitor of U46619-induced rat platelet aggregation and exhibited superior selectivity for the TP receptor versus other G protein-coupled receptors and a PKC activator...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27930489/screening-and-preliminary-verification-of-a-phage-display-single-chain-antibody-library-against-coal-workers-pneumoconiosis
#16
Guang-Hui Zhang, Li Li, Changfu Hao, Jing-Chao Ren, Hongyi Zhang, Jie Jiao, Liyun Gao, Shibin Ding, Sanqiao Yao, Wu Yao, Weidong Wu
OBJECTIVES: To construct a phage display human antibody library (PDHAL) against pneumoconiosis for the diagnosis and treatment of coal worker pneumoconiosis (CWP). METHODS: The PDHAL was established via CWP blood and six positive antibodies were discovered. 867 coal workers (558 CWP and 309 without CWP) and 393 controls were recruited to validate the results. RESULTS: A PDHAL against CWP was established, from which six strong positive clones were selected, sequenced and identified as VEGF, interleukin-18, HSP70, HER3, Gz-B and RF...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27901267/binge-alcohol-intake-after-hypergravity-stress-sustainably-decreases-ampk-and-transcription-factors-necessary-for-hepatocyte-survival
#17
Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung, Sang Geon Kim
BACKGROUND: Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27882299/application-of-target-capture-sequencing-of-exons-and-conserved-non-coding-sequences-to-20-inbred-rat-strains
#18
Minako Yoshihara, Tetsuya Sato, Daisuke Saito, Osamu Ohara, Takashi Kuramoto, Mikita Suyama
We report sequence data obtained by our recently devised target capture method TargetEC applied to 20 inbred rat strains. This method encompasses not only all annotated exons but also highly conserved non-coding sequences shared among vertebrates. The total length of the target regions covers 146.8 Mb. On an average, we obtained 31.7 × depth of target coverage and identified 154,330 SNVs and 24,368 INDELs for each strain. This corresponds to 470,037 unique SNVs and 68,652 unique INDELs among the 20 strains...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27864074/clinically-isolated-enterovirus-a71-subgenogroup-c4-strain-with-lethal-pathogenicity-in-14-day-old-mice-and-the-application-as-an-ev-a71-mouse-infection-model
#19
Yi Xu, Shuzhi Ma, Limeng Zhu, Zhiqiu Huang, Liyun Chen, Yuhua Xu, Haibin Yin, Tao Peng, Yi Wang
The Enterovirus A71 (EV-A71) subgenogroup C4 is prevalent in China. EV-A71 causes hand, foot and mouth disease (HFMD) in children and may lead to severe neurological diseases. The development of antiviral and protective vaccines against EV-A71 is significantly hindered by the lack of suitable animal models to recapitulate human neurological symptoms. In this study, GZ-CII, a highly virulent EV-A71 subgenogroup C4 strain, was isolated from hospitalized children with HFMD. Intraperitoneal infections of GZ-CII resulted in progressive neurological disease in mice as old as 14 days...
January 2017: Antiviral Research
https://www.readbyqxmd.com/read/27855637/protein-ligand-specific-binding-residue-predictions-by-an-ensemble-classifier
#20
Xiuzhen Hu, Kai Wang, Qiwen Dong
BACKGROUND: Prediction of ligand binding sites is important to elucidate protein functions and is helpful for drug design. Although much progress has been made, many challenges still need to be addressed. Prediction methods need to be carefully developed to account for chemical and structural differences between ligands. RESULTS: In this study, we present ligand-specific methods to predict the binding sites of protein-ligand interactions. First, a sequence-based method is proposed that only extracts features from protein sequence information, including evolutionary conservation scores and predicted structure properties...
November 17, 2016: BMC Bioinformatics
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