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Jing Zhang, Jing Li, Li Yang, Chen Yuan, Yi-Quan Zhang, You Song
A family of trigonal antiprismatic Co(II) complexes was synthesized, which exhibited field-induced Raman process dominated single-molecule magnet behavior. Despite the coordination environment of Co(II) being of similar symmetry, the four complexes exhibit distinct dynamic magnetic properties owing to their packing arrangements and dipole-dipole interactions. On the basis of computational results we have demonstrated that the gz and giso values follow a cosine relation with respect to the rotated angle φ (twist angle φ defined as the rotation angle of one coordination square away from the eclipse conformation to the other)...
March 12, 2018: Inorganic Chemistry
Emiel Cracco, Lara Bardi, Charlotte Desmet, Oliver Genschow, Davide Rigoni, Lize De Coster, Ina Radkova, Eliane Deschrijver, Marcel Brass
Automatic imitation is the finding that movement execution is facilitated by compatible and impeded by incompatible observed movements. In the past 15 years, automatic imitation has been studied to understand the relation between perception and action in social interaction. Although research on this topic started in cognitive science, interest quickly spread to related disciplines such as social psychology, clinical psychology, and neuroscience. However, important theoretical questions have remained unanswered...
March 8, 2018: Psychological Bulletin
Rachel J Fenske, Michelle E Kimple
Since its discovery and purification by Frederick Banting in 1921, exogenous insulin has remained almost the sole therapy for type 1 diabetes mellitus. While insulin alleviates the primary dysfunction of the disease, many other aspects of the pathophysiology of type 1 diabetes mellitus are unaffected. Research aimed towards the discovery of novel type 1 diabetes mellitus therapeutics targeting different cell signaling pathways is gaining momentum. The focus of these efforts has been almost entirely on the impact of immunomodulatory drugs, particularly those that have already received FDA-approval for other autoimmune diseases...
January 1, 2018: Experimental Biology and Medicine
Xian-Rong Shen, Xiu-Li Chen, Hai-Xia Xie, Ying He, Wei Chen, Qun Luo, Wei-Hong Yuan, Xue Tang, Deng-Yong Hou, Ding-Wen Jiang, Qing-Rong Wang
BACKGROUND: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound healing...
October 27, 2017: Military Medical Research
Silvia Gregori, Maria Grazia Roncarolo
T regulatory cells, a specialized subset of T cells, are key players in modulating antigen (Ag)-specific immune responses in vivo . Inducible T regulatory type 1 (Tr1) cells are characterized by the co-expression of CD49b and lymphocyte-activation gene 3 (LAG-3) and the ability to secrete IL-10, TGF-β, and granzyme (Gz) B, in the absence of IL-4 and IL-17. The chief mechanisms by which Tr1 cells control immune responses are secretion of IL-10 and TGF-β and killing of myeloid cells via GzB. Tr1 cells, first described in peripheral blood of patients who developed tolerance after HLA-mismatched fetal liver hematopoietic stem cell transplantation, have been proven to modulate inflammatory and effector T cell responses in several immune-mediated diseases...
2018: Frontiers in Immunology
Hesham Haffez, David R Chisholm, Natalie J Tatum, Roy Valentine, Christopher Redfern, Ehmke Pohl, Andrew Whiting, Stefan Przyborski
Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ). Polar interactions between receptor and ligand are important for binding and facilitating the non-polar interactions and conformational changes necessary for RAR-mediated transcriptional regulation. The constraints on activity and RAR-type specificity with respect to the structural link between the polar and non-polar functions of synthetic retinoids are poorly understood...
February 10, 2018: Bioorganic & Medicinal Chemistry
Bai-Jun Li, Jie-Yu Wang, Zhong-Jian Liu, Xue-Ying Zhuang, Jiu-Xiang Huang
BACKGROUND: Loropetalum subcordatum is an endangered species endemic to China that is characterized by narrow distribution, small population size, and delayed fertilization. However, the genetic diversity of the entire extant natural and ex situ populations has not been assessed to date. In this study, we evaluated the genetic diversity and structure of six natural populations and a single ex situ population (the only known ex situ population of L. subcordatum) using sequence-related amplified polymorphism data...
February 13, 2018: BMC Genetics
Na-Ra Lee, Guangrong Zheng, Peter A Crooks, Michael T Bardo, Linda P Dwoskin
Despite increased methamphetamine use worldwide, pharmacotherapies are not available to treat methamphetamine use disorder. The vesicular monoamine transporter-2 (VMAT2) is an important pharmacological target for discovery of treatments for methamphetamine use disorder. VMAT2 inhibition by the natural product, lobeline, reduced methamphetamine-evoked dopamine release, methamphetamine-induced hyperlocomotion, and methamphetamine self-administration in rats. Compared to lobeline, lobelane exhibited improved affinity and selectivity for VMAT2 over nicotinic acetylcholine receptors...
February 9, 2018: AAPS Journal
Sung Hwa Song, Ji Eun Kim, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong, Dae Youn Hwang
PURPOSE: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. MATERIALS AND METHODS: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. RESULTS: SCTF showed high tensile strength (1...
February 7, 2018: Journal of Dermatological Treatment
Mariusz Kubus, Arianna Lanza, Rebecca Scatena, Leonardo H R Dos Santos, Björn Wehinger, Nicola Casati, Christoph Fiolka, Lukas Keller, Piero Macchi, Christian Rüegg, Karl W Krämer
Two Cu2+ coordination polymers [CuCl(pyz)2](BF4) 1 and [CuBr(pyz)2](BF4) 2 (pyz = pyrazine) were synthesized in the family of quasi two-dimensional (2D) [Cu(pyz)2]2+ magnetic networks. The layer connectivity by monatomic halide ligands results in significantly shorter interlayer distances. Structures were determined by single-crystal X-ray diffraction. Temperature-dependent X-ray diffraction of 1 revealed rigid [Cu(pyz)2]2+ layers that do not expand between 5 K and room temperature, whereas the expansion along the c-axis amounts to 2%...
February 1, 2018: Inorganic Chemistry
Shihao Song, Shuna Fu, Xiuyun Sun, Peng Li, Ji'en Wu, Tingyan Dong, Fei He, Yinyue Deng
Ralstonia solanacearum is a causative agent of bacterial wilt in many important crops throughout the world. How to control bacterial wilt caused by R. solanacearum is a major problem in agriculture. In this study, we aim to isolate the biocontrol agents that have high efficacy in the control of bacterial wilt. Three new bacterial strains with high antimicrobial activity against R. solanacearum GMI1000 were isolated and identified. Our results demonstrated that these bacteria could remarkably inhibit the disease index of host plant infected by R...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute in vitro epilepsy model induced in hippocampal brain slice preparations by exposure to the GABAA receptor blocker gabazine (GZ), the AHP was previously shown to be significantly decreased. Here, we asked the question whether KCa2...
January 9, 2018: Neurobiology of Disease
Xiaohua Douglas Zhang, Zhaozhi Zhang, Dandan Wang
Summary: The R package CGManalyzer contains functions for analyzing data from a continuous glucose monitoring (CGM) study. It covers a wide and comprehensive range of data analysis methods including reading a series of datasets, obtaining summary statistics of glucose levels, plotting data, transforming the time stamp format, fixing missing values, evaluating the mean of daily difference (MODD) and continuous overlapping net glycemic action (CONGA), calculating multiscale sample entropy (MSE), conducting pairwise comparison, displaying results using various plots including a new type of plot called an antenna plot, etc...
January 5, 2018: Bioinformatics
Gang Yu, Benli Jia, Yunsheng Cheng, Lianbang Zhou, Bo Qian, Zhining Liu, Yong Wang
One of the features for pancreatic cancer is that it is often resistant to chemotherapy treatment, which is one of the major hindrances in the treatment of this malignancy. Previous studies indicated that the microRNAs (miRNAs) could mediate resistance of tumor cells to chemotherapy drug in the cancer progression. In the present study, we are aimed to examine whether microRNA-429 was involved in mediating the chemo-resistance of pancreatic cancer cells to gemcitabine. Firstly, a gemcitabine-resistant pancreatic cancer cell line (SW1990/GZ) derived from cell line (SW1990) was constructed and found to possess a decreased expression of miR-429 when it is compared to the original cell line...
2017: American Journal of Translational Research
Deepika Delsa Dean, Sarita Agarwal, Deepa Kapoor, Kuldeep Singh, Chandra Vati
BACKGROUND: Fragile X syndrome is caused by CGG repeat expansion mutation in the FMR1 gene. Normal alleles have 5-44 CGG repeats with AGG interruptions. The expanded gray zone (GZ) (45-54 repeats) and premutation (PM) (55-200 repeats) alleles are often uninterrupted and are unstably inherited in subsequent generations. The prevalence of PM and GZ carriers is high in the female population, at 1/66 and 1/113, respectively, and PM is associated with fertility problems in 20% of cases. OBJECTIVE: Our objective was to molecularly characterize CGG repeats and AGG interruption sequences in the FMR1 gene in women of reproductive age and in women with premature ovarian insufficiency (POI)...
February 2018: Molecular Diagnosis & Therapy
Xing-Xing Shi, Yuexing Zhang, Qiu-Jie Chen, Zheng Yin, Xue-Li Chen, Zhenxing Wang, Zhong-Wen Ouyang, Mohamedally Kurmoo, Ming-Hua Zeng
Herein, quasi-square planar CuII (Hmbm)Cl2 (CBC, Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol) was arranged in a pseudo orthogonal way to form Cl-bridged chains, and further ππ interactions resulted in distorted hexagonal layers. DFT calculations reveal a bond strength order of Cu-Cl > Cu-O/N ≫ CuCl. ESI-MS data reveal several small fragments from CBC, but oligomeric [Cu], [Cu], and [Cu] for non-zero in-source energies; MS data indicates the occurrence of several chemical processes, viz. splitting of the ligand, oligomerization, and redox reaction of alcohol to aldehyde and CuII to CuI ...
December 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Di Wu, Chao Zheng, Ji Wu, Rongrong Huang, Xuanyu Chen, Tong Zhang, Lili Zhang
INTRODUCTION: The rate of intervertebral disc degeneration (IVDD) is influenced by environmental factors. Extracellular matrix (ECM) destruction and apoptosis of intervertebral disc cells are major characteristics of IVDD. ECM degradation is closely linked to up-regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMP). This study aimed to elucidate the molecular biological changes during IVDD under conditions of weightlessness and hypergravity. METHODS: A total of 120 rabbits were divided randomly into four groups: control group, weightlessness group, hypergravity group, and mixed (hypergravity + weightlessness) group...
December 1, 2017: Aerospace Medicine and Human Performance
Sethuraman Muthuramalingam, Themmila Khamrang, Marappan Velusamy, Ramasamy Mayilmurugan
New copper(ii) complexes, [Cu(L1)2 (H2 O)](ClO4 )2 , 1 [L1 = 2-pyridin-2-yl-quinoline], [Cu(L2)2 (H2 O)](ClO4 )2 , 2 [L2 = 2-pyridin-2-yl-quinoxaline], [Cu(L3)2 (H2 O)](ClO4 )2 , 3 [L3 = 6,7-dimethyl-2-pyridin-2-yl-quinoxaline], [Cu(L4)2 (H2 O)](ClO4 )2 , 4 [L4 = 4-phenyl-2-pyridin-2-yl-quinoline] and [Cu(L5)2 (H2 O)](ClO4 )2 , 5 [L5 = 4-phenyl-2-pyridin-2-yl-quinazoline], were synthesized and characterized as catalysts for selective fixation of atmospheric CO2 . The molecular structure of 2 was determined by single-crystal X-ray studies and shown to have an unusual trigonal bipyramid geometry (τ, 0...
November 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian, Yuehua Huang
BACKGROUND: There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK cell immunity. METHODS: A total of 237 eligible CHB patients and 22 healthy controls were enrolled in our study. Demographic and clinical data were collected, and the CHB phases (immune active-IA, immune tolerant phase-IT, inactive CHB-IC, and grey zone-GZ) were classified according to the latest American Association for the Study of Liver Disease guidelines...
October 31, 2017: Journal of Translational Medicine
Arne Tribukait, Ola Eiken
BACKGROUND: An aircraft's orientation relative to the ground cannot be perceived via the sense of balance or the somatosensory system. When devoid of external visual references, the pilot must rely on instruments. A sudden unexpected instrument indication is a challenge to the pilot, who might have to question the instrument instead of responding with the controls. In this case report we analyze, from a human-factors perspective, how a limited instrument failure led to a fatal accident...
November 1, 2017: Aerospace Medicine and Human Performance
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