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Huilin Jiang, Yunmei Li, Junrong Mo, Xiaohui Chen, Min Li, Peiyi Lin, Kevin K C Hung, Timothy H Rainer, Colin A Graham
BACKGROUND: Hong Kong (HK) and Guangzhou (GZ) are cities in China with different healthcare systems. This study aimed to compare 30-day and 6-month mortality and characteristics of patients with suspected cardiac chest pain admitted to two emergency departments (ED) in HK and GZ. METHODS: A prospective observational study enrolled patients with suspected cardiac chest pain presenting to EDs in the Prince of Wales Hospital (PWH), HK and the Second Affiliated Hospital of Guangzhou Medical University (AHGZMU),GZ...
May 16, 2018: BMC Cardiovascular Disorders
Gustavo Z Schaun, Stephanie S Pinto, Mariana R Silva, Davi B Dolinski, Cristine L Alberton
Schaun, GZ, Pinto, SS, Silva, MR, Dolinski, DB, and Alberton, CL. Sixteen weeks of whole-body high-intensity interval training induce similar cardiorespiratory responses compared with traditional high-intensity interval training and moderate-intensity continuous training in healthy men. J Strength Cond Res XX(X): 000-000, 2018-Low-volume high-intensity interval training (HIIT) protocols that use the body weight as resistance could be an interesting and inexpensive alternative to traditional ergometer-based high-intensity interval training (HIIT-T) and moderate-intensity continuous training (MICT)...
May 7, 2018: Journal of Strength and Conditioning Research
Tuomas Honkanen, Matti Mäntysaari, Janne Avela, Heikki Kyröläinen, Tuomo Leino
Introduction: The high acceleration (Gz) exposure among military pilots flying fighter aircraft has been associated with an increased risk for cervical and lumbar disorders. It has been suggested that an adequate level of physical performance could reduce the risk of experiencing these disorders. The Finnish Air Force has for several years used aerobic (bicycle ergometer) and muscular fitness tests (battery of five tests) in the selection process of military pilot candidates in order to evaluate their physical fitness level...
May 8, 2018: Military Medicine
Ivan Potočňák, Oleksandr Bukrynov, Andrii Kliuikov, Erik Čiǽmár, Svitlana Vitushkina, Lucia Váhovská, Michal Dušek
The complex (2,2'-biquinoline-κ2 N,N')(carbamoylcyanonitrosomethanide-κ2 N,O)chloridocopper(II) acetonitrile monosolvate, [Cu(C3 H2 N3 O2 )Cl(C18 H12 N2 )]·CH3 CN or [Cu(ccnm)Cl(biq)]·acn (acn is acetonitrile, biq is 2,2'-biquinoline and ccnm is carbamoylcyanonitrosomethanide), (I), was prepared as a result of nucleophilic addition of water to the dicyanonitrosomethanide ion in the presence of CuII and biq. IR spectroscopy confirmed the presence of ccnm, biq and acn in (I). The solid-state structure consists of the neutral complex containing ccnm and biq ligands, coordinated to the CuII atom in a bidendate chelating manner, and a chloride ligand, resulting in a distorted tetragonal pyramidal coordination of CuII ...
May 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Paula Beck, Jens Tank, Peter Gauger, Luis E J Beck, Hubert Zirngibl, Jens Jordan, Ulrich Limper
PURPOSE: Since manned missions to the Moon and Mars are planned, we conducted active standing tests with lunar, Martian, terrestrial, and 1.8 loads of inertial resistance (+Gz ) modeled through defined parabolic flight maneuvers. We hypothesized that the cardiovascular response to active standing is proportional to the +Gz load. METHODS: During partial-+Gz parabolic flights, 14 healthy test subjects performed active stand-up maneuvers under 1 +Gz , lunar (0.16 +Gz ), Martian (0...
April 26, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
David St-Pierre, Jérôme Cabana, Brian J Holleran, Élie Besserer-Offroy, Emanuel Escher, Gaétan Guillemette, Pierre Lavigne, Richard Leduc
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be significantly investigated. However, an important but often overlooked aspect of functional selectivity is the capability of ligands such as angiotensin II (AngII) to adopt specific conformations that may preferentially bind to selective GPCRs structures...
April 20, 2018: Biochemical Pharmacology
Guoqiang Zhao, Yanqing Sheng, Chuanyuan Wang, Jian Yang, Qiaoning Wang, Lingxin Chen
Marine oil spill pollution is an important environmental problem in the world, especially crude oil-soaked marine sediments, because they are difficult to be remediated. In this study, in situ bioremediation of oil-soaked sediment was performed in the middle of the Bohai Sea. Oil-degrading bacteria were adsorbed on powdery zeolite (PZ)/granular zeolites (GZ) surfaces and then wrapped with poly-γ glutamic acid (γ-PGA). Settling column and wave flume experiments were conducted to model marine conditions and to select appropriate biological reagents...
April 2018: Marine Pollution Bulletin
Keishi Mizuguchi, Toshihide Horiike, Naoyuki Matsumoto, Yoshie Ichikawa, Yohei Shinmyo, Hiroshi Kawasaki
Microglia have been attracting much attention because of their fundamental importance in both the mature brain and the developing brain. Though important roles of microglia in the developing cerebral cortex of mice have been uncovered, their distribution and roles in the developing cerebral cortex in gyrencephalic higher mammals have remained elusive. Here we examined the distribution and morphology of microglia in the developing cerebral cortex of gyrencephalic carnivore ferrets. We found that a number of microglia were accumulated in the germinal zones (GZs), especially in the outer subventricular zone (OSVZ), which is a GZ found in higher mammals...
April 3, 2018: Neurochemical Research
Claudine M Kraan, Quang M Bui, Mike Field, Alison D Archibald, Sylvia A Metcalfe, Louise M Christie, Bruce H Bennetts, Ralph Oertel, Melanie J Smith, Desiree du Sart, Damien Bruno, Tiffany L Wotton, David J Amor, David Francis, David E Godler
PurposeDevelopmental delay phenotypes have been associated with FMR1 premutation (PM: 55-200 CGG repeats) and "gray zone" (GZ: 45-54 CGG repeats) alleles. However, these associations have not been confirmed by larger studies to be useful in pediatric diagnostic or screening settings.MethodsThis study determined the prevalence of PM and GZ alleles in two independent cohorts of 19,076 pediatric referrals to developmental delay diagnostic testing through Victorian Clinical Genetics Service (cohort 1: N = 10,235; cohort 2: N = 8841), compared with two independent general population cohorts (newborn screening N = 1997; carrier screening by the Victorian Clinical Genetics Service prepair program N = 14,249)...
March 29, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
M Bonacci, S Lens, Z Mariño, M-C Londoño, S Rodríguez-Tajes, A Mas, M García-López, S Pérez-Del-Pulgar, J M Sánchez-Tapias, X Forns
BACKGROUND: Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS: We assessed the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS: Retrospective analysis of 287 IC and GZ HBeAg-negative patients. Patients were classified into 4 groups at baseline: HBV-DNA <2000 IU/mL and ALT <40 U/L (IC), HBV-DNA <2000 IU/mL and ALT 40-80 U/L (GZ-1), HBV-DNA 2000-20 000 IU/mL and ALT <40 U/L (GZ-2) or ALT 40-80 U/L (GZ-3)...
March 25, 2018: Alimentary Pharmacology & Therapeutics
Jing Zhang, Jing Li, Li Yang, Chen Yuan, Yi-Quan Zhang, You Song
A family of trigonal antiprismatic Co(II) complexes was synthesized, which exhibited field-induced Raman process dominated single-molecule magnet behavior. Despite the coordination environment of Co(II) being of similar symmetry, the four complexes exhibit distinct dynamic magnetic properties owing to their packing arrangements and dipole-dipole interactions. On the basis of computational results we have demonstrated that the g z and giso values follow a cosine relation with respect to the rotated angle φ (twist angle φ defined as the rotation angle of one coordination square away from the eclipse conformation to the other)...
April 2, 2018: Inorganic Chemistry
Emiel Cracco, Lara Bardi, Charlotte Desmet, Oliver Genschow, Davide Rigoni, Lize De Coster, Ina Radkova, Eliane Deschrijver, Marcel Brass
Automatic imitation is the finding that movement execution is facilitated by compatible and impeded by incompatible observed movements. In the past 15 years, automatic imitation has been studied to understand the relation between perception and action in social interaction. Although research on this topic started in cognitive science, interest quickly spread to related disciplines such as social psychology, clinical psychology, and neuroscience. However, important theoretical questions have remained unanswered...
May 2018: Psychological Bulletin
Rachel J Fenske, Michelle E Kimple
Since its discovery and purification by Frederick Banting in 1921, exogenous insulin has remained almost the sole therapy for type 1 diabetes mellitus. While insulin alleviates the primary dysfunction of the disease, many other aspects of the pathophysiology of type 1 diabetes mellitus are unaffected. Research aimed towards the discovery of novel type 1 diabetes mellitus therapeutics targeting different cell signaling pathways is gaining momentum. The focus of these efforts has been almost entirely on the impact of immunomodulatory drugs, particularly those that have already received FDA-approval for other autoimmune diseases...
March 2018: Experimental Biology and Medicine
Xian-Rong Shen, Xiu-Li Chen, Hai-Xia Xie, Ying He, Wei Chen, Qun Luo, Wei-Hong Yuan, Xue Tang, Deng-Yong Hou, Ding-Wen Jiang, Qing-Rong Wang
BACKGROUND: Wounded personnel who work at sea often encounter a plethora of difficulties. The most important of these difficulties is seawater immersion. Common medical dressings have little effect when the affected area is immersed in seawater, and only rarely dressings have been reported for the treatment of seawater-immersed wounds. The objective of this study is to develop a new dressing which should be suitable to prevent the wound from seawater immersion and to promote the wound healing...
October 27, 2017: Military Medical Research
Silvia Gregori, Maria Grazia Roncarolo
T regulatory cells, a specialized subset of T cells, are key players in modulating antigen (Ag)-specific immune responses in vivo . Inducible T regulatory type 1 (Tr1) cells are characterized by the co-expression of CD49b and lymphocyte-activation gene 3 (LAG-3) and the ability to secrete IL-10, TGF-β, and granzyme (Gz) B, in the absence of IL-4 and IL-17. The chief mechanisms by which Tr1 cells control immune responses are secretion of IL-10 and TGF-β and killing of myeloid cells via GzB. Tr1 cells, first described in peripheral blood of patients who developed tolerance after HLA-mismatched fetal liver hematopoietic stem cell transplantation, have been proven to modulate inflammatory and effector T cell responses in several immune-mediated diseases...
2018: Frontiers in Immunology
Hesham Haffez, David R Chisholm, Natalie J Tatum, Roy Valentine, Christopher Redfern, Ehmke Pohl, Andrew Whiting, Stefan Przyborski
Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ). Polar interactions between receptor and ligand are important for binding and facilitating the non-polar interactions and conformational changes necessary for RAR-mediated transcriptional regulation. The constraints on activity and RAR-type specificity with respect to the structural link between the polar and non-polar functions of synthetic retinoids are poorly understood...
May 1, 2018: Bioorganic & Medicinal Chemistry
Bai-Jun Li, Jie-Yu Wang, Zhong-Jian Liu, Xue-Ying Zhuang, Jiu-Xiang Huang
BACKGROUND: Loropetalum subcordatum is an endangered species endemic to China that is characterized by narrow distribution, small population size, and delayed fertilization. However, the genetic diversity of the entire extant natural and ex situ populations has not been assessed to date. In this study, we evaluated the genetic diversity and structure of six natural populations and a single ex situ population (the only known ex situ population of L. subcordatum) using sequence-related amplified polymorphism data...
February 13, 2018: BMC Genetics
Na-Ra Lee, Guangrong Zheng, Peter A Crooks, Michael T Bardo, Linda P Dwoskin
Despite increased methamphetamine use worldwide, pharmacotherapies are not available to treat methamphetamine use disorder. The vesicular monoamine transporter-2 (VMAT2) is an important pharmacological target for discovery of treatments for methamphetamine use disorder. VMAT2 inhibition by the natural product, lobeline, reduced methamphetamine-evoked dopamine release, methamphetamine-induced hyperlocomotion, and methamphetamine self-administration in rats. Compared to lobeline, lobelane exhibited improved affinity and selectivity for VMAT2 over nicotinic acetylcholine receptors...
February 9, 2018: AAPS Journal
Sung Hwa Song, Ji Eun Kim, Eun Kyoung Koh, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong, Dae Youn Hwang
PURPOSE: Aims of this study is to evaluate the therapeutic effects and toxicity of Se-loaded cellulose film originated from Styela clava tunic (SeSCTF) on cutaneous wounds during diabetic conditions. MATERIALS AND METHODS: Alterations in skin regeneration, angiogenesis and toxicity were examined using streptozotocine (STZ)-induced diabetic Sprague Dawley® (SD) rats with surgical skin wounds after application of SeSCTF for 12 days. RESULTS: SCTF showed high tensile strength (1...
February 7, 2018: Journal of Dermatological Treatment
Mariusz Kubus, Arianna Lanza, Rebecca Scatena, Leonardo H R Dos Santos, Björn Wehinger, Nicola Casati, Christoph Fiolka, Lukas Keller, Piero Macchi, Christian Rüegg, Karl W Krämer
Two Cu2+ coordination polymers [CuCl(pyz)2 ](BF4 ) 1 and [CuBr(pyz)2 ](BF4 ) 2 (pyz = pyrazine) were synthesized in the family of quasi two-dimensional (2D) [Cu(pyz)2 ]2+ magnetic networks. The layer connectivity by monatomic halide ligands results in significantly shorter interlayer distances. Structures were determined by single-crystal X-ray diffraction. Temperature-dependent X-ray diffraction of 1 revealed rigid [Cu(pyz)2 ]2+ layers that do not expand between 5 K and room temperature, whereas the expansion along the c-axis amounts to 2%...
February 1, 2018: Inorganic Chemistry
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