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https://www.readbyqxmd.com/read/28502923/g-protein-coupled-receptor-signaling-through-gpr176-gz-and-rgs16-tunes-time-in-the-center-of-the-circadian-clock-review
#1
Kaoru Goto, Masao Doi, Tianyu Wang, Sumihiro Kunisue, Iori Murai, Hitoshi Okamura
G-protein-coupled receptors (GPCRs) constitute an immensely important class of drug targets with diverse clinical applications. There are still more than 120 orphan GPCRs whose cognate ligands and physiological functions are not known. A set of circadian pacemaker neurons that governs daily rhythms in behavior and physiology resides in the suprachiasmatic nucleus (SCN) in the brain. Malfunction of the circadian clock has been linked to a multitude of diseases, such as sleeping disorders, obesity, diabetes, cardiovascular diseases, and cancer, which makes the clock an attractive target for drug development...
May 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28440282/understanding-the-rising-phase-of-the-pm2-5-concentration-evolution-in-large-china-cities
#2
Baolei Lv, Jun Cai, Bing Xu, Yuqi Bai
Long-term air quality observations are seldom analyzed from a dynamic view. This study analyzed fine particulate matter (PM2.5) pollution processes using long-term PM2.5 observations in three Chinese cities. Pollution processes were defined as linearly growing PM2.5 concentrations following the criteria of coefficient of determination R(2) > 0.8 and duration time T ≥ 18 hrs. The linear slopes quantitatively measured pollution levels by PM2.5 concentrations rising rates (PMRR, μg/(m(3)·hr))...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430608/adrenalectomy-abolishes-hypergravity-induced-gastric-acid-hyposecretion
#3
Kiyong Na, Hyun-Soo Kim
Jet fighter pilots experience high gravitational acceleration forces in the cephalocaudal direction (+Gz), causing severe stress. Stress affects different physiological functions of the gastrointestinal tract. Although the effects of exposure to hypergravity on cardiovascular and cerebral functions have been the subject of numerous studies, crucial information regarding potential pathophysiological alterations following hypergravity exposure in the gastrointestinal tract is lacking. We recently documented a significant decrease in gastric secretory activity in rats after acute exposure to hypergravity...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419290/svmqa-support-vector-machine-based-protein-single-model-quality-assessment
#4
Balachandran Manavalan, Jooyoung Lee
Motivation: The accurate ranking of predicted structural models and selecting the best model from a given candidate pool remain as open problems in the field of structural bioinformatics. The quality assessment (QA) methods used to address these problems can be grouped into two categories: consensus methods and single-model methods. Consensus methods in general perform better and attain higher correlation between predicted and true quality measures. However, these methods frequently fail to generate proper quality scores for native-like structures which are distinct from the rest of the pool...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28419211/the-inhibitory-g-protein-%C3%AE-subunit-g%C3%AE-z-promotes-type-1-diabetes-like-pathophysiology-in-nod-mice
#5
Rachel J Fenske, Mark T Cadena, Quincy E Harenda, Haley N Wienkes, Kathryn Carbajal, Michael D Schaid, Erin Laundre, Allison L Brill, Nathan A Truchan, Harpreet Brar, Jaclyn Wisinski, Jinjin Cai, Timothy E Graham, Feyza Engin, Michelle E Kimple
The alpha subunit of the heterotrimeric Gz protein, Gαz, promotes beta-cell death and inhibits beta-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gαz protein would preserve functional beta-cell mass in the non-obese diabetic (NOD) model, protecting from overt diabetes. We saw that protection from diabetes was robust and durable up to 35 weeks of age in Gαz knockout mice. By 17 weeks of age, Gαz-null NOD mice had significantly higher diabetes-free survival than wild-type littermates...
April 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28400494/uv-b-inhibits-leaf-growth-through-changes-in-growth-regulating-factors-and-gibberellin-levels
#6
Julieta Fina, Romina Casadevall, Hamada AbdElgawad, Els Prinsen, Marios Nektarios Markakis, Gerrit T S Beemster, Paula Casati
UV-B radiation affects leaf growth in a wide range of species. In this work, we demonstrate that UV-B levels present in solar radiation inhibits maize leaf growth without causing any other visible stress symptoms, including accumulation of DNA damage. We conducted kinematic analyses of cell division and expansion to understand the impact of UV-B radiation on these cellular processes. Our results demonstrate that the decrease in leaf growth in UV-B irradiated leaves is a consequence of a reduction in cell production, and a shortened growth zone (GZ)...
April 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28377193/anthropogenic-mercury-emissions-from-1980-to-2012-in-china
#7
Ying Huang, Meihua Deng, Tingqiang Li, Jan Japenga, Qianqian Chen, Xiaoe Yang, Zhenli He
China was considered the biggest contributor for airborne mercury in the world but the amount of mercury emission in effluents and solid wastes has not been documented. In this study, total national and regional mercury emission to the environment via exhaust gases, effluents and solid wastes were accounted with updated emission factors and the amount of goods produced and/or consumed. The national mercury emission in China increased from 448 to 2151 tons during the 1980-2012 period. Nearly all of the emissions were ended up as exhaust gases and solid wastes...
April 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28341935/a-natural-triterpenoid-saponin-as-multifunctional-stabilizer-for-drug-nanosuspension-powder
#8
Yingchong Chen, Yang Liu, Junnan Xu, Yuanbiao Xie, Qin Zheng, Pengfei Yue, Ming Yang
The objective of this study is to prepare a novel drug nanosuspension modified by a natural triterpenoid saponin (glycyrrhizin (GZ)) and evaluate its stability and redispersibility. A poorly soluble drug (andrographolide (AGE)) was used as a model drug. AGE nanosuspensions (AGE-NS) using GZ as natural stabilizer with mean particle size of 487 nm were firstly prepared by homogenization and converted into dried AGE nanosuspension powder (AGE-NP) by freeze-drying. It was found that GZ was able to prevent the aggregation of AGE nanocrystals and the freeze-dried AGE-NP could easily redisperse back to AGE-NS...
March 24, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28339010/effects-of-different-cellulose-membranes-regenerated-from-styela-clava-tunics-on-wound-healing
#9
Sung Hwa Song, Keum Yong Seong, Ji Eun Kim, Jun Go, Eun Kyoung Koh, Ji Eun Sung, Hong Joo Son, Young Jin Jung, Hye Sung Kim, Jin Tae Hong, Dae Youn Hwang
The aim of this study was to investigate the therapeutic effects of three different cellulose membranes (CMs) manufactured from Styela clava tunics (SCTs) on the healing of cutaneous wounds. We examined the physical properties and therapeutic effects of three CMs regenerated from SCTs (referred to as SCT‑ CMs), including normal CM (SCT‑CM), freeze-dried SCT‑CM (FSCT‑CM) and sodium alginate-supplemented SCT‑CM (ASCT‑CM) on skin regeneration and angiogenesis using Sprague-Dawley (SD) rats. FSCT‑CM exhibited an outstanding interlayered structure, a high tensile strength (1...
May 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28323584/evidence-for-gz-adaptation-observed-with-wearable-biosensors-during-high-performance-jet-flight
#10
G Merrill Rice, Dallas Snider, Jeffrey L Moore, J Timothy Lavan, Rich Folga, Thomas B VanBrunt
INTRODUCTION: Few studies have evaluated physiological responses to high acceleration forces during actual flight and to our knowledge no normative data has been acquired by technologies such as wearable biosensors during high performance jet aircraft operations. METHODS: In-flight physiological data from an FDA cleared portable triaxial accelerometer and bio-sensor were observed from five active duty F-18 pilots of the Naval Flight Demonstration Squadron (Blue Angels)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28301141/reconstitution-and-substrate-specificity-of-the-radical-s-adenosyl-methionine-thiazole-c-methyltransferase-in-thiomuracin-biosynthesis
#11
Nilkamal Mahanta, Zhengan Zhang, Graham A Hudson, Wilfred A van der Donk, Douglas A Mitchell
Thiomuracin is a thiopeptide antibiotic with potent activity toward Gram-positive drug-resistant bacteria. Thiomuracin is biosynthesized from a precursor peptide, TbtA, by a complex array of posttranslational modifications. One of several intriguing transformations is the C-methylation of thiazole, occurring at an unactivated sp(2) carbon. Herein, we report the in vitro reconstitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which catalyzes the formation of 5-methylthiazole at a single site...
March 29, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28289129/helios-expression-coordinates-the-development-of-a-subset-of-striatopallidal-medium-spiny-neurons
#12
Raquel Martín-Ibáñez, Mónica Pardo, Albert Giralt, Andrés Miguez, Inés Guardia, Lucile Marion-Poll, Cristina Herranz, Miriam Esgleas, Gerardo Garcia-Díaz Barriga, Michael J Edel, Carlos Vicario-Abejón, Jordi Alberch, Jean-Antoine Girault, Susan Chan, Philippe Kastner, Josep M Canals
Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons, which express dopamine 2 receptor and enkephalin. To exert this effect, He is expressed in neural progenitor cells (NPCs) keeping them in the G1/G0 phase of the cell cycle. Thus, a lack of He results in an increase of S-phase entry and S-phase length of NPCs, which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ), which end up dying at postnatal stages...
April 15, 2017: Development
https://www.readbyqxmd.com/read/28274441/preparation-of-glycosylated-zein-and-retarding-effect-on-lipid-oxidation-of-ground-pork
#13
Xiao-Jie Wang, Xi-Qun Zheng, Xiao-Lan Liu, Narasimha-Kumar Kopparapu, Wan-Suo Cong, Yong-Ping Deng
The focus of the present work was to investigate the glycosylation of zein, partial properties of the glycosylated zein (GZ) and its retarding effect on lipid oxidation of ground pork. Zein was glycosylated with chitosan (MW 1500Da) by microbial transglutaminase, the reaction was verified by FT-IR. Under the optimized conditions, 97.48mg of glucosamine was covalently conjugated to 1g of zein, determined by HPLC. The solubility and the surface hydrophobicity of GZ were significantly improved. In vitro studies of GZ showed a dose-dependent scavenging activity against free radicals of DPPH, superoxide and hydroxyl radical, and the EC50 value for DPPH radical was 1...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28271884/electrostatic-potential-determined-magnetic-dynamics-observed-in-two-mononuclear-%C3%AE-diketone-dysprosium-iii-single-molecule-magnets
#14
Pei-Pei Cen, Sheng Zhang, Xiang-Yu Liu, Wei-Ming Song, Yi-Quan Zhang, Gang Xie, San-Ping Chen
Two β-diketone mononuclear Dy(III) compounds, formulated as Dy(BTFA)3(H2O)2 (1) and Dy(BTFA)3(bpy) (2) (BTFA = 3-benzoyl-1,1,1-trifluoroacetone, bpy = 2,2'-bipyridine), were prepared. Compound 1 can be identified to transform to 2 in the attendance of bpy coligand, when the local geometry symmetry of eight-coordinated Dy(III) ion changes from a dodecahedron (D2d) in 1 to a square antiprism (D4d) in 2. Fine-tuning structure aroused by auxiliary ligand has dramatical impact on magnetic properties of compounds 1 and 2...
March 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28268313/alterations-in-cardiovascular-system-under-artificially-simulated-microgravity-preliminary-study
#15
Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova
The main goal of this work is to study the alterations occurred in human cardiovascular system under artificially simulated microgravity by using special short-arm centrifuge. We have used arterial blood pressure, ankle-brachial pressure index and accelerated photoplethysmography approach to determine the effects of artificially simulated microgravity on vascular system. The group of 30 healthy male volunteers was studied in a short-arm human centrifuge at two levels of gravity gradients along head-to-foot direction (Gz): normal gravity gradient of 1 Gz and so called microgravity mode of 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28252967/hyperfine-sublevel-correlation-spectroscopy-studies-of-iron-sulfur-cluster-in-rieske-protein-from-green-sulfur-bacterium-chlorobaculum-tepidum
#16
Hiroki Nagashima, Hiraku Kishimoto, Risa Mutoh, Naotaka Terashima, Hirozo Oh-Oka, Genji Kurisu, Hiroyuki Mino
The magnetic properties of the Rieske protein purified from Chlorobaculum tepidum were investigated using electron paramagnetic resonance and hyperfine sublevel correlation spectroscopy (HYSCORE). The g-values of the Fe2S2 center were gx = 1.81, gy = 1.90, and gz = 2.03. Four classes of nitrogen signals were obtained by HYSCORE. Nitrogens 1 and 2 had relatively strong magnetic hyperfine couplings and were assigned as the nitrogen directly ligated to Fe. Nitrogens 3 and 4 had relatively weak magnetic hyperfine couplings and were assigned as the other nitrogen of the His ligands and peptide nitrogen connected to the sulfur atom via hydrogen bonding, respectively...
March 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28226473/alterations-in-cardiovascular-system-under-artificially-simulated-microgravity-preliminary-study
#17
Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova, Aleksandr A Fedotov, Sergey A Akulov, Anna S Akulova, Aleksandr A Fedotov, Anna S Akulova, Sergey A Akulov
The main goal of this work is to study the alterations occurred in human cardiovascular system under artificially simulated microgravity by using special short-arm centrifuge. We have used arterial blood pressure, ankle-brachial pressure index and accelerated photoplethysmography approach to determine the effects of artificially simulated microgravity on vascular system. The group of 30 healthy male volunteers was studied in a short-arm human centrifuge at two levels of gravity gradients along head-to-foot direction (Gz): normal gravity gradient of 1 Gz and so called microgravity mode of 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28163357/tube-side-mass-transfer-for-hollow-fibre-membrane-contactors-operated-in-the-low-graetz-range
#18
C Y Wang, E Mercer, F Kamranvand, L Williams, A Kolios, A Parker, S Tyrrel, E Cartmell, E J McAdam
Transformation of the tube-side mass transfer coefficient derived in hollow fibre membrane contactors (HFMC) of different characteristic length scales (equivalent diameter and fibre length) has been studied when operated in the low Graetz range (Gz<10). Within the low Gz range, mass transfer is generally described by the Graetz problem (Sh=3.67) which assumes that the concentration profile comprises a constant shape over the fibre radius. In this study, it is experimentally evidenced that this assumption over predicts mass transfer within the low Graetz range...
February 1, 2017: Journal of Membrane Science
https://www.readbyqxmd.com/read/28130775/delphiforce-a-tool-for-electrostatic-force-calculations-applications-to-macromolecular-binding
#19
Lin Li, Arghya Chakravorty, Emil Alexov
Long-range electrostatic forces play an important role in molecular biology, particularly in macromolecular interactions. However, calculating the electrostatic forces for irregularly shaped molecules immersed in water is a difficult task. Here, we report a new tool, DelPhiForce, which is a tool in the DelPhi package that calculates and visualizes the electrostatic forces in biomolecular systems. In parallel, the DelPhi algorithm for modeling electrostatic potential at user-defined positions has been enhanced to include triquadratic and tricubic interpolation methods...
April 5, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28103202/erratum-for-the-paper-cytology-of-pericardial-effusion-due-to-malignancy-kalogeraki-a-lazopoulos-g-papadakis-gz-tamiolakis-d-karvela-kalogeraki-i-karvelas-kalogerakis-m-segredakis-j-papadakis-m-moustou-e-datseri-g-chalkiadakis-ge-tzardi-m-rom-j-intern-med-2016
#20
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