Zheng-Kun Song, Li Zhao, De-Shen Liu, Ling-Na Zhao, Qin-Bao Peng, Zi-Yao Li, Jia-Yong Wu, Si-Kai Chen, Fang-Ze Huang, Xing Chen, Tian-Xiao Lin, Li Guan, Wei-Peng Meng, Jia-Wei Guo, Yue-Nian Su, Xiao-Xia He, Si-Jia Liang, Peng Zhu, Shao-Yi Zheng, Song-Lin Du, Xiu Liu
BACKGROUND: Macrophage-derived foam cells are a hallmark of atherosclerosis. Scavenger receptors, including lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (OLR-1), are the principal receptors responsible for the uptake and modification of LDL, facilitating macrophage lipid load and the uptake of oxidized LDL by arterial wall cells. Krüppel-like factor 15 (KLF15) is a transcription factor that regulates the expression of genes by binding to the promoter during transcription...
November 18, 2023: Journal of Molecular and Cellular Cardiology