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https://www.readbyqxmd.com/read/28906326/tissue-engineering-strategies-for-auricular-reconstruction
#1
Michael J Schroeder, Mark S Lloyd
Simulating natural characteristics and aesthetics in reconstructed ears has provided a complex 3-dimensional puzzle for those treating patients with microtia. Costochondral grafts remain the gold standard for autologous reconstruction. However, other options such as Medpor and prosthetics are indicated depending on patient circumstances and personal choice. Research into tissue engineering offers an alternative method to a traditional surgical approach that may reduce donor-site morbidity. However, tissue engineering for microtia reconstruction brings new challenges such as cell sourcing, promotion of chondrogenesis, scaffold vascularization, and prevention of scaffold contraction...
September 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28858277/-bone-anchored-auricular-prosthesis-for-patients-with-grade-iii-microtia
#2
T Z Chkadua, S V Abramyan, I I Sukharskiy, A R Arsenidze, T D Cholokava
The aim of the study was to assess the effectivity of auricular prosthesis on intraosseous implants in patient with grade III microtia. The study included 7 patients (5 males and 2 females) aged 18 to 45 years with hemifacial microsomia and grade III microtia operated in Central Research Institute of Dentistry and Maxillofacial Surgery in 2013-2016. Number and position of intraosseous implants was determined by reverse planning based on CT representing hard and soft facial structures. Patients were followed-up for 6-36 months...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28857620/active-transcutaneous-bone-conduction-implant-audiological-results-in-paediatric-patients-with-bilateral-microtia-associated-with-external-auditory-canal-atresia
#3
Sofía Bravo-Torres, Carolina Der-Mussa, Eduardo Fuentes-López
OBJECTIVE: To describe, in terms of functional gain and word recognition, the audiological results of patients under 18 years of age implanted with the active bone conduction implant, Bonebridge™. DESIGN: Retrospective case studies conducted by reviewing the medical records of patients receiving implants between 2014 and 2016 in the public health sector in Chile. STUDY SAMPLE: All patients implanted with the Bonebridge were included (N = 15)...
August 31, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28841618/intelligence-and-academic-achievement-of-adolescents-with-craniofacial-microsomia
#4
Matthew L Speltz, Erin R Wallace, Brent R Collett, Carrie L Heike, Daniela V Luquetti, Martha M Werler
BACKGROUND: The authors compared the IQ and academic achievement of adolescents with craniofacial microsomia (cases) and unaffected children (controls). Among cases, the authors analyzed cognitive functioning by facial phenotype. METHODS: The authors administered standardized tests of intelligence, reading, spelling, writing, and mathematics to 142 cases and 316 controls recruited from 26 cities across the United States and Canada. Phenotypic classification was based on integrated data from photographic images, health history, and medical chart reviews...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28798549/autologous-ear-reconstruction
#5
REVIEW
Asaf Olshinka, Matthew Louis, Tuan A Truong
Since the pioneering use of autologous rib cartilage for the reconstruction of microtia, there have been significant advances in surgical technique that have helped to ameliorate the psychological burden of microtia. To date, the use of rib cartilage for auricular reconstruction is one of the most enduring and ubiquitous techniques for microtia reconstruction as it provides excellent aesthetic results with lasting durability. In this review, the authors outline the most common methods of microtia reconstruction with a comparison of each technique and illustrative case examples...
August 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28798546/otologic-and-audiology-concerns-of-microtia-repair
#6
REVIEW
Kausar Ali, Kriti Mohan, Yi-Chun Liu
Microtia is a congenital auricular deformity that commonly presents with associated congenital aural atresia. The most acute concern in these patients is concomitant hearing loss at birth. A team-based approach by plastic surgeons and otologists is necessary to address both the otologic and audiologic concerns of microtia and atresia. Hearing rehabilitation is imperative; yet it should not compromise the aesthetic components of reconstruction and vice versa. Here, the authors propose a framework to evaluate and manage patients with microtia and atresia with the goal of optimizing functional and cosmetic outcomes...
August 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28764250/microtia-in-all-the-siblings-of-a-family-a-rare-case
#7
Somashekar Gejje, Brijesh Mishra, Amrita Anandkumar Hongal
No abstract text is available yet for this article.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28734754/cost-analysis-of-microtia-treatment-in-the-netherlands
#8
M N Kolodzynski, C V A van Hövell Tot Westerflier, M Kon, C C Breugem
INTRODUCTION: Ear reconstruction for microtia is a challenging procedure. Although analyzing esthetic outcome is crucial, there is a paucity of information with regard to financial aspects of microtia reconstruction. This study was conducted to analyze the costs associated with ear reconstruction with costal cartilage in patients with microtia. METHODS: Ten consecutive children with autologous ear reconstruction of a unilateral microtia were included in this analysis...
September 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28692518/costal-cartilage-assessment-in-surgical-timing-of-microtia-reconstruction
#9
Zhongyang Sun, Xiaobo Yu, Weiwei Chen, Qinghua Yang, Yupeng Song, Jiayu Zhou, Haiyue Jiang
BACKGROUND: Rib cartilage growth is closely related to age and determines the feasibility and outcomes of auricular reconstruction. Ear reconstruction is performed as early as age 6 in efforts to treat children before school matriculation while allowing for sufficient rib growth. But there is controversy over the optimal timing of microtia reconstruction. This study employs CT imaging and surface scanning to guide the timing of auricular reconstruction in children. METHODS: A retrospective analysis was performed on 6-year-old microtia patients between January 2016 and June 2016...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28688561/uncovering-the-pathogenesis-of-microtia-using-bioinformatics-approach
#10
Liu Lei, Liu Zhenzhong, Lin Lin, Pan Bo
OBJECTIVE: Bioinformatics is widely used in the field of cancer research, but in the research of pathogenesis of congenital malformations the situation is different. The aim of this study was to explore the underlying mechanism using bioinformatics approach. METHODS: The data were available from Mouse Genome Informatics and Pubmed. Protein-protein interaction (PPI) network of pathogenic genes was conducted using STRING. Gene ontology and pathway enrichment analyses were also performed to pathogenic genes...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28687022/target-sequencing-of-307-deafness-genes-identifies-candidate-genes-implicated-in-microtia
#11
Pu Wang, Xinmiao Fan, Yibei Wang, Yue Fan, Yaping Liu, Shuyang Zhang, Xiaowei Chen
Microtia is a congenital malformation of the external ear caused by genetic and/or environmental factors. However, no causal genetic mutations have been identified in isolated microtia patients. In this study, we utilized targeted genomic capturing combined with next-generation sequencing to screen for mutations in 307 deafness genes in 32 microtia patients. Forty-two rare heterozygous mutations in 25 genes, including 22 novel mutations in 24 isolated unilateral microtia cases were identified. Pathway analysis found five pathways especially focal adhesion pathway and ECM-receptor interaction pathway were significantly associated with microtia...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28664390/clinical-application-of-intense-pulsed-light-depilation-technology-in-total-auricular-reconstruction
#12
Ying Guo, Jing Shan, Tianyu Zhang
Although ear reconstruction technology has been highly developed in recent years, hair growth on the reconstructed ear has plagued both surgeons and patients. In this paper, the authors introduce a clinical application of intense pulsed light depilation in total auricular reconstruction. From August 2012 to August 2013, 27 patients (28 ears) suffering from congenital microtia were treated by intense pulsed light depilation (650-950-nm filter, initial fluence of 14-16 J/cm(2) and gradually increased, pulse width of 30-50 ms, spot size of 20 × 30 mm(2), intervals of 6-8 weeks, a total of four sessions) either before or after auricular reconstruction...
August 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28643009/patient-satisfaction-and-its-influencing-factors-of-microtia-reconstruction-using-autologous-cartilage
#13
Chunxiao Cui, Shim Yoon Hoon, Ruhong Zhang, Qun Zhang, Zhicheng Xu, Feng Xu, Datao Li, Yiyuan Li
BACKGROUND: This study aimed to investigate patient perceptions of and satisfaction with surgical outcomes of microtia reconstruction using autologous cartilage. It also analyzes associations between patient background characteristics and their evaluation. METHODS: Lobule-type microtia patients who had received first-stage surgery were interviewed using a questionnaire, which included assessment of nine auricle substructures, superior and inferior parts and overall impression...
June 22, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28636731/correlation-among-external-auditory-canal-anomaly-temporal-bone-malformation-and-hearing-levels-in-patients-with-microtia
#14
Kun Chen, Liu Liu, Runjie Shi, Peihua Wang, Dong Chen, Hua Xiao
We conducted a retrospective study to evaluate the relationship between external auditory canal (EAC) anomaly, temporal bone abnormality, and hearing levels using objective scoring systems in Chinese patients with microtia. The study population consisted of 106 ears of 94 Chinese patients (67 male and 27 female) aged 5 to 45 years (mean: 12.6) with microtia. The EAC abnormalities were classified into 4 types according to Schuknecht's criteria: type A, type B, type C, and type D. Developmental anomalies of the temporal bone were evaluated by Jahrsdoerfer computed tomography (CT) scoring system using high-resolution CT scans of the temporal bone...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28636124/the-ips-scale-a-new-soft-tissue-assessment-scale-for-percutaneous-and-transcutaneous-implants-for-bone-conduction-devices
#15
Ivo J Kruyt, Rik C Nelissen, Martin L Johansson, Emmanuel A M Mylanus, Myrthe K S Hol
Percutaneous titanium implants for bone conduction devices (BCDs) have offered, since 1977, a solution for patients with hearing loss not treatable by conventional hearing aids, such as patients with chronic ear infections or microtia and/or ear canal atresia. Percutaneous implants imply a continuous breach in the mechanical defensive barrier of the skin. To compensate for this breach, immunological mechanisms in the subcutaneous tissue surrounding the implant become more active. This article is protected by copyright...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28625897/differential-expression-of-long-noncoding-rnas-in-congenital-microtia
#16
Ling Zhang, Lin Lin, Yu-Peng Song, Bo Pan, Qing-Hua Yang, Hai-Yue Jiang
OBJECTIVE: To analyse lncRNA expression profiles in microtia using bioinformatics analysis. METHODS: We examined lncRNA expression profiles in residual ear cartilage and normal ear cartilage from individual congenital microtia patients. RESULTS: The gene chips used in this study included 30586 lncRNAs and 26109 mRNA probes. Intotal, 180 lncRNAs with differential expression weredetected in the residual ear cartilage compared with the normal cartilage, including 74 up-regulated and 106down-regulated lncRNAs...
June 15, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28538573/pursuing-mirror-image-reconstruction-in-unilateral-microtia-customizing-auricular-framework-by-application-of-three-dimensional-imaging-and-three-dimensional-printing
#17
Hsin-Yu Chen, Li-Shia Ng, Chun-Shin Chang, Ting-Chen Lu, Ning-Hung Chen, Zung-Chung Chen
BACKGROUND: Advances in three-dimensional imaging and three-dimensional printing technology have expanded the frontier of presurgical design for microtia reconstruction from two-dimensional curved lines to three-dimensional perspectives. This study presents an algorithm for combining three-dimensional surface imaging, computer-assisted design, and three-dimensional printing to create patient-specific auricular frameworks in unilateral microtia reconstruction. METHODS: Between January of 2015 and January of 2016, six patients with unilateral microtia were enrolled...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28473682/bilateral-microtia-canal-atresia-and-aplasia-of-cochleovestibular-nerve
#18
A Asma, A R Roslenda, I Fadzilah, A Mazita, M B Marina, A Ab Aziz
A six-month-old baby with congenital patent ductus arteriosus (PDA), bilateral microtia and canal atresia was referred for hearing assessment. The audiology assessment revealed bilateral profound hearing loss, which is atypical for a case of pure canal atresia. Imaging was performed much earlier than usual and, as suspected, the patient also had bilateral severe inner ear anomaly. It is extremely rare for a person to have both external and inner ear anomaly because of the different embryological origin. The only suitable hearing rehabilitation option for this kind of patients is brainstem implant...
April 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28468140/microtia-and-social-media-patient-versus-physician-perspective-of-quality-of-information
#19
Sarvnaz Sepehripour, Ann Louise McDermott, Mark Sheldon Lloyd
INTRODUCTION: Previous research demonstrates that patients seek high-quality information on the World Wide Web, especially in rare conditions such as microtia. Social media has overtaken other sources of patient information but quality remains untested. This study quantifies the quality of information for patients with Microtia on social media compared with nonsocial media websites and compares physician and patient scoring on quality using the DISCERN tool. METHODS: In phase 1, quality of the top 100 websites featuring information "Microtia" was ranked according to quality score and position on Google showing the position of social media websites among other nonsocial media websites...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28465028/the-technique-for-3d-printing-patient-specific-models-for-auricular-reconstruction
#20
Roberto L Flores, Hannah Liss, Samuel Raffaelli, Aiza Humayun, Kimberly S Khouri, Paulo G Coelho, Lukasz Witek
PURPOSE: Currently, surgeons approach autogenous microtia repair by creating a two-dimensional (2D) tracing of the unaffected ear to approximate a three-dimensional (3D) construct, a difficult process. To address these shortcomings, this study introduces the fabrication of patient-specific, sterilizable 3D printed auricular model for autogenous auricular reconstruction. METHODS: A high-resolution 3D digital photograph was captured of the patient's unaffected ear and surrounding anatomic structures...
April 6, 2017: Journal of Cranio-maxillo-facial Surgery
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