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Angina pectoris

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https://www.readbyqxmd.com/read/29132649/doppler-versus-thermodilution-derived-coronary-microvascular-resistance-to-predict-coronary-microvascular-dysfunction-in-patients-with-acute-myocardial-infarction-or-stable-angina-pectoris
#1
Rupert P Williams, Guus A de Waard, Kalpa De Silva, Matthew Lumley, Kaleab Asrress, Satpal Arri, Howard Ellis, Awais Mir, Brian Clapp, Amedeo Chiribiri, Sven Plein, Paul F Teunissen, Maurits R Hollander, Michael Marber, Simon Redwood, Niels van Royen, Divaka Perera
Coronary microvascular resistance is increasingly measured as a predictor of clinical outcomes, but there is no accepted gold-standard measurement. We compared the diagnostic accuracy of 2 invasive indices of microvascular resistance, Doppler-derived hyperemic microvascular resistance (hMR) and thermodilution-derived index of microcirculatory resistance (IMR), at predicting microvascular dysfunction. A total of 54 patients (61 ± 10 years) who underwent cardiac catheterization for stable coronary artery disease (n = 10) or acute myocardial infarction (n = 44) had simultaneous intracoronary pressure, Doppler flow velocity and thermodilution flow data acquired from 74 unobstructed vessels, at rest and during hyperemia...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29131250/effects-of-remote-ischemic-preconditioning-on-myocardial-injury-and-endothelial-function-and-prognosis-after-percutaneous-coronary-intervention-in-patients-with-acute-coronary-syndrome
#2
F-Z Zhou, W Song, L-H Yin, Z-F Song, S Yang, F-B Yang, J-F Liu, Y-G Song, H-Y Zhang, Z-M Zhang
OBJECTIVE: To explore the effects of remote ischemic preconditioning on myocardial injury and prognosis after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome. PATIENTS AND METHODS: The study was a single center, prospective, randomized, controlled study. A total of 184 patients with unstable angina undergoing elective PCI were randomly assigned to remote ischemic preconditioning group (induced by four times of 5-min inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion at 1 h before PCI therapy) or control group (an uninflated cuff around the arm)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29126583/effect-of-changes-in-physical-activity-on-risk-for-cardiac-death-in-patients-with-coronary-artery-disease
#3
Minna Lahtinen, Tomi Toukola, M Juhani Junttila, Olli-Pekka Piira, Samuli Lepojärvi, Maria Kääriäinen, Heikki V Huikuri, Mikko P Tulppo, Antti M Kiviniemi
Leisure-time physical activity (LTPA) is associated with longevity in patients with coronary artery disease (CAD). However, less is known about prognostic significance of longitudinally assessed LTPA in patients with stable CAD. The present study assessed the relationship between changes in LTPA and cardiac mortality in patients with CAD. Patients with angiographically documented CAD (n = 1,746) underwent clinical examination and echocardiography at the baseline. Lifestyle factors, including LTPA (inactive, irregularly active, active, highly active), were surveyed at baseline and after 2 years' follow-up...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29122526/extracorporeal-myocardial-shockwave-therapy-a-precious-blast-for-refractory-angina-patients
#4
Massimo Slavich, Giuseppe Pizzetti, Anna Maria Vella, Claudia Carlucci, Davide Margonato, Roberto Spoladore, Gabriele Fragasso, Alberto Margonato
INTRODUCTION: Refractory Angina Pectoris (RAP) dramatically affects patients' life quality and medical costs. External Shockwave Myocardial Revascularization (ESMR) improves the cardiac blood flow thanks to its pro-angiogenetic action on ischaemic tissues. We hereby describe our experience of ESMR in RAP patients. MATERIALS AND METHODS: This is a retrospective study encompassing all patients referred to OSR for RAP treatment. Efficacy of ESMR was assessed considering the difference between pre and post therapy data in SAQ score and CCS, stress test performance, 24h ECG monitoring, NT-proBNP and echocardiographic measures...
October 3, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29116618/treatment-of-stable-angina-with-a-new-fixed-dose-combination-of-ivabradine-and-metoprolol-effectiveness-and-tolerability-in-routine-clinical-practice
#5
Dimitar Divchev, Georg Stöckl
INTRODUCTION: In this prospective, multicenter, observational cohort study, the effectiveness and tolerability of the first fixed-dose combination (FDC) formulation of the selective heart rate reducing agent ivabradine and the beta-blocker metoprolol was evaluated in stable angina pectoris (AP) patients in a clinical practice setting. METHODS: Stable AP outpatients received a FDC of ivabradine and metoprolol (b.i.d.) for 4 months, in addition to cardiovascular standard therapy...
November 7, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/29113786/pulmonary-dysfunction-and-development-of-different-cardiovascular-outcomes-in-the-general-population
#6
Inken Padberg, Alice Schneider, Ulrike Grittner, Manuel C Olma, Thomas Liman, Bob Siegerink
BACKGROUND: Pulmonary dysfunction and cardiovascular disease are major causes of impaired health status in later life, and co-development of these diseases has been reported. AIM: To better understand the pathobiology involved in the co-development of these diseases. METHODS: We investigated the impact of pulmonary dysfunction on the development of cardiovascular disease among people aged≥50 years in the English longitudinal study of ageing (ELSA)...
November 4, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29108790/the-association-between-electrocardiographic-r-wave-peak-time-and-coronary-artery-disease-severity-in-patients-with-non-st-segment-elevation-myocardial-infarction-and-unstable-angina-pectoris
#7
İbrahim Rencüzoğulları, Metin Çağdaş, Süleyman Karakoyun, Yavuz Karabağ, Mahmut Yesin, İnanç Artaç, Doğan İliş, Murat Selçuk, Mesut Öterkuş, Halil İbrahim Tanboğa
BACKGROUND: We aimed to evaluate possible association between QRS duration (QRSD), R wave peak time (RWPT), and coronary artery disease severity identified using the SYNTAX score (SS) in patients with unstable angina pectoris (USAP) or non-ST segment elevation myocardial infarction (NSTEMI). METHOD: A total of 176 USAP/NSTEMI patients were enrolled in the study. RESULTS: The high SS group (>22, n:45) patients had a higher prevalence of diabetes mellitus (DM); presence of ST segment depression ≥0...
September 27, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29103734/relationship-between-optical-coherence-tomography-derived-morphological-criteria-and-functional-relevance-as-determined-by-fractional-flow-reserve
#8
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Tadashi Fukuda, Hiroaki Ohya, Yohei Sumino, Rikuta Hamaya, Yoshinori Kanno, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: Although several previous studies have indicated that optical coherence tomography (OCT)-derived minimal lumen area (MLA) correlates with fractional flow reserve (FFR) severity, other morphologic criteria for functionally significant coronary stenosis assessed by FFR have not been fully elucidated. This study aimed to identify OCT-based morphological predictors of physiologically significant ischemia assessed by FFR in angiographically intermediate coronary lesions. METHODS: We investigated 194 de novo intermediate coronary lesions in 178 patients with stable angina pectoris who underwent OCT imaging and FFR measurement...
November 2, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29097387/neopterin-as-an-effect-modifier-of-the-cardiovascular-risk-predicted-by-total-homocysteine-a-prospective-2-cohort-study
#9
Espen Ø Bjørnestad, Robert A Borsholm, Gard F T Svingen, Eva R Pedersen, Reinhard Seifert, Øivind Midttun, Per M Ueland, Grethe S Tell, Kaare H Bønaa, Ottar Nygård
BACKGROUND: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon-γ-mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the association between tHcy and subsequent risk of acute myocardial infarction (AMI) was modified by systemic concentrations of neopterin and C-reactive protein among patients with coronary heart disease. METHODS AND RESULTS: By Cox modeling, we explored the association between tHcy and risk of AMI in 4164 patients with suspected stable angina pectoris...
November 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29096811/the-role-of-nitroglycerin-and-other-nitrogen-oxides-in-cardiovascular-therapeutics
#10
REVIEW
Sanjay Divakaran, Joseph Loscalzo
The use of nitroglycerin in the treatment of angina pectoris began not long after its original synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better understanding of its roles in vasodilation, cell permeability, platelet function, inflammation, and other vascular processes have advanced our knowledge of the hemodynamic (mostly mediated through vasodilation of capacitance and conductance arteries) and nonhemodynamic effects of organic nitrate therapy, via both nitric oxide-dependent and -independent mechanisms...
November 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29093154/evolution-of-risk-factors-for-atherosclerotic-cardiovascular-events-in-systemic-lupus-erythematosus-a-longterm-prospective-study
#11
Konstantinos Tselios, Dafna D Gladman, Jiandong Su, Olga Ace, Murray B Urowitz
OBJECTIVE: We previously reported the effect of certain factors on cardiovascular disease (CVD) in 250 women with systemic lupus erythematosus (SLE) followed for 8 years. The aim of this study was to delineate their evolution after 15 years of followup. METHODS: There were 210 women with SLE and 138 age-matched healthy women available for analysis after 15 years. Cardiovascular events (CVE) included angina pectoris, myocardial infarction (fatal and nonfatal), transient ischemic attack, and stroke (fatal and nonfatal)...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29081147/-clinical-characteristics-and-prognosis-in-the-patients-of-stroke-after-percutaneous-coronary-intervention
#12
X F Tang, Z Gao, J J Xu, Y Song, Y L Ma, H H Wang, L Jiang, P Jiang, R Liu, L J Gao, Y Zhang, L Song, J Chen, Y J Yang, R L Gao, B Xu, J Q Yuan
Objective: To investigate the clinical characteristics and prognosis in patients with stroke after percutaneous coronary intervention (PCI). Methods: From January 2013 to December 2013, 10 724 consecutive patients undergoing PCI including acute coronary syndrome and stable angina pectoris were enrolled.A two years' follow up was conducted among these patients to investigate the clinical characteristics and prognosis of patients with stroke and of those without. A comparison was done between the two groups. Results: One hundred and forty-five patients had stroke (1...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29070468/-screening-and-verification-of-plasma-biomarkers-for-stable-angina-pectoris-a-differential-proteomic-analysis
#13
An-Na Shen, Shui-Wang Hu, Jing Huang, De-Zhong Zheng, Zhao-Ting Hu
OBJECTIVE: To compare and analyze the differentially expressed plasma proteome between patients with stable angina pectoris (SAP) and healthy donors to identify the biomarkers for early diagnosis of SAP. METHODS: Plasma samples from 60 patients with SAP and 60 healthy controls were collected. Twenty samples (100 mL each) randomly selected from each group were pooled and after removing high-abundance proteins from the pooled plasma, two-dimensional gel electrophoresis (2DE) was performed to isolate the total proteins...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29064792/anti-inflammatory-and-endothelium-protective-effect-of-long-term-pioglitazone-intake-in-patients-suffering-from-bronchial-asthma-concurrent-with-ischemic-heart-disease
#14
Oksana V Byelan, Tetiana V Mamontova, Liudmyla E Vesnina, Oksana A Borzykh, Igor P Kaidashev
INTRODUCTION: Treatment of co-morbidities, including bronchial asthma (BA) and coronary heart disease (CHD), is a relevant issue of modern therapy. The aim of the research is to study the impact of long-term intake of pioglitazone on the development of inflammation and ED in patients with BA concurrent with CHD. MATERIAL AND METHODS: The clinical study involved 50 people aged 40-75 who suffered from asthma concurrent with CHD. On the first day of the study, blood samples were collected and clinical examinations were performed, after which patients were randomized and divided into the control group who continued to receive only the standard therapy, and the study group, who received pioglitazone (Pioglar, Ranbaxy, India) 15 mg once a day along with comprehensive therapy...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29064791/effect-of-quercetin-on-parameters-of-central-hemodynamics-and-myocardial-ischemia-in-patients-with-stable-coronary-heart-disease
#15
Natalia I Chekalina, Svitlana V Shut, Tetiana A Trybrat, Yurii H Burmak, Yeuhen Ye Petrov, Yulia I Manusha, Yurii M Kazakov
THE AIM: The aim of our research was to study the effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD). MATERIAL AND METHODS: The research involved 85 patients with CHD: stable angina pectoris, FC II, and 30 healthy individuals made up the control group. After 1.5 months of stabilizing therapy (ß-blockers, statins, aspirin) patients with CHD were randomized into 2 groups - the research group (30 people) and the comparison group (55 people)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29062343/expression-of-mir-126-and-its-potential-function-in-coronary-artery-disease
#16
Xiaoyan Wang, Yajun Lian, Xin Wen, Jing Guo, Zhiping Wang, Sheng Jiang, Yaodong Hu
OBJECTIVE: This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis. METHODOLOGY: A total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29059644/resveratrol-has-a-positive-effect-on-parameters-of-central-hemodynamics-and-myocardial-ischemia-in-patients-with-stable-coronary-heart-disease
#17
Nataliya I Chekalina
INTRODUCTION: Cardiovascular diseases, and primarily coronary heart disease (CHD), are the leading cause of mortality in the developing countries, including Ukraine. Prognosis for patients with CHD depends mainly on progression of coronary atherosclerosis (ASVD). Molecular mechanisms of atherogenesis are studied in detail in order to find new targets of pharmacological intervention. THE AIM: to study the effect of resveratrol on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29049018/prevalence-of-single-and-multiple-leading-causes-of-death-by-race-ethnicity-among-us-adults-aged-60-to-79-years
#18
James Davis, Janell Penha, Omar Mbowe, Deborah A Taira
INTRODUCTION: Diabetes, cancer, cardiovascular disease (CVD) (coronary artery disease, heart attack, and angina pectoris), and chronic lung disease (emphysema, chronic bronchitis, and chronic obstructive pulmonary disease) are major causes of death in the United States. The objective of this study was to assess racial/ethnic differences in the prevalence of these conditions as cause of death among people aged 60 to 79 years with one or more of these conditions. METHODS: We used data on the prevalence of major chronic conditions from the National Health Interview Survey on 56,290 adults aged 60 to 79 years who reported having any of the chronic conditions assessed in the National Health Interview Survey for 2006 through 2014...
October 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29047360/comparison-of-circulating-dendritic-cell-and-monocyte-subsets-at-different-stages-of-atherosclerosis-insights-from-optical-coherence-tomography
#19
Jianhui Zhuang, Yang Han, Dachun Xu, Guofu Zhu, Shekhar Singh, Luoman Chen, Mengyun Zhu, Wei Chen, Yawei Xu, Xiankai Li
BACKGROUND: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear. METHODS: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography...
October 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29046002/-optimal-diagnostics-and-therapy-for-microvascular-angina-pectoris
#20
Peter Ong, Udo Sechtem
Patients with microvascular angina are characterized by angina pectoris with proof of myocardial ischemia in the absence of any relevant epicardial stenosis and without myocardial disease (type 1 coronary microvascular dysfunction according to Crea and Camici). Structural and functional alterations of the coronary microvessels (diameter < 500 µm) are the reason for this phenomenon. Frequently such alterations are associated with cardiovascular risk factors. Patients with angina pectoris without epicardial stenoses represent for 10 - 50 % of all patients undergoing coronary angiography depending on the clinical presentation...
October 2017: Deutsche Medizinische Wochenschrift
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