keyword
https://read.qxmd.com/read/37602347/orbital-liposarcoma-a-retrospective-single-center-study-of-thirteen-patients
#21
JOURNAL ARTICLE
Ning Gao, Xin Ge, Cheng Pei, Jian-Min Ma, Ya-Guang Hu
AIM: To explore the clinical and pathological characteristics of thirteen patients with orbital liposarcoma. METHODS: The clinical history data of thirteen patients diagnosed as orbital liposarcoma at Beijing Tongren Hospital, from 2006 to 2021 were collected and analyzed. The data includes age, gender, affected orbital side, course of disease, status of disease (primary or recurrent), clinical manifestations, preoperative visual acuity, operative treatment, the relations between liposarcoma and surrounding tissue, longest diameter of liposarcoma, histological subtype, immunohistochemical indicators, follow-up treatment and prognosis...
2023: International Journal of Ophthalmology
https://read.qxmd.com/read/37550974/-clinical-analysis-of-corneal-interface-infection
#22
JOURNAL ARTICLE
Y Zhang, Z Q Wang, S J Deng, K X Chen, X G Sun
Objective: To analyze the clinical features of corneal interface infection. Methods: A retrospective case series study was conducted to explore the clinical features of interstitial corneal infection. The data of eight patients (eight eyes) who were diagnosed with interstitial corneal infection after undergoing corneal transplant or corneal refractive surgery and visited Beijing Tongren Eye Center from January to December 2018 were collected, including two male and six female patients aged between 18 and 55 years (median age, 27 years)...
August 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/37534663/-carbamazepine-induced-stevens-johnson-syndrome-in-han-chinese-with-positive-hla-a-3101-gene-a-case-report
#23
JOURNAL ARTICLE
Y Y Xu, Z L Sun, X L Zhang, Z L Liu, W Liu, X Guan
Stevens-Johnson syndrome is a type of severe drug eruption, which is characterized by rapid onset and rapid progress. If not treated in time, it can develop into toxic epidermal necrolysis, even life-threatening. Common sensitizing drugs include sulfa, carbamazepine, etc. In China, reports and studies of carbamazepine causing Stevens-Johnson syndrome mainly focus on the HLA-B * 1502 gene, and there are no reports of HLA-A * 3101 gene positive. We reported a patient who got Stevens-Johnson syndrome with HLA-A * 3101 gene positive caused by carbamazepine...
August 18, 2023: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/37448746/collapsin-response-mediator-protein-5-associated-optic-neuropathy-clinical-characteristics-radiologic-clues-and-outcomes
#24
JOURNAL ARTICLE
Rong Yan, Yu Mao, Huiyang Zeng, Qian Liu, Hanqiu Jiang, Jingting Peng, Qingling Yang, Shilei Cui, Lei Liu, Yanjun Guo, Jiawei Wang
OBJECTIVE: Collapsin response mediator protein 5-associated optic neuropathy (CRMP5-ON) is a rare entity of autoimmune optic neuropathy. This study aimed to review the neuro-ophthalmic findings and outcomes in a series of patients with CRMP5-ON to further characterize its clinical phenotype, radiologic clues, and outcomes. METHODS: This was a retrospective case series and a single-center medical chart review of all patients with CRPM5-seropositive ON at the Department of Neurology, Beijing Tongren Hospital, from December 1, 2020, to March 31, 2023...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37420223/exploration-on-surgery-of-malignant-glaucoma-with-prolonged-absence-of-the-anterior-chamber-a-retrospective-consecutive-case-series
#25
JOURNAL ARTICLE
Yan Liu, Tao Wang
OBJECTIVE: To evaluate the surgical outcomes of anterior chamber restoration in patients with malignant glaucoma and a prolonged absence of the anterior chamber. METHODS: Five patients with malignant glaucoma and a long-term absence of the anterior chamber underwent a combination of anterior pars plana vitrectomy (aPPV), phacoemulsification cataract excision, intraocular lens implantation, peripheral iridotomy (PI), goniosynechialysis (GSL) (referred to aPPV + P + I + PI + GSL) at Beijing Tongren Hospital from October 2018 to June 2021...
July 7, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37416799/relationships-between-quantitative-retinal-microvascular-characteristics-and-cognitive-function-based-on-automated-artificial-intelligence-measurements
#26
JOURNAL ARTICLE
Xu Han Shi, Li Dong, Rui Heng Zhang, Deng Ji Zhou, Sai Guang Ling, Lei Shao, Yan Ni Yan, Ya Xing Wang, Wen Bin Wei
Introduction: The purpose of this study is to assess the relationship between retinal vascular characteristics and cognitive function using artificial intelligence techniques to obtain fully automated quantitative measurements of retinal vascular morphological parameters. Methods: A deep learning-based semantic segmentation network ResNet101-UNet was used to construct a vascular segmentation model for fully automated quantitative measurement of retinal vascular parameters on fundus photographs. Retinal photographs centered on the optic disc of 3107 participants (aged 50-93 years) from the Beijing Eye Study 2011, a population-based cross-sectional study, were analyzed...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37408426/-analysis-of-the-correlation-between-peripapillary-retinal-nerve-fiber-layer-cross-sectional-area-and-myopia-in-individuals-aged-50-years-and-above
#27
JOURNAL ARTICLE
Y N Yan, W B Wei
Objective: To measure the peripapillary retinal nerve fiber layer (RNFL) cross-sectional area in individuals aged 50 years and above with different refractive errors, and analyze its correlation with axial length and refractive error. Methods: This was a cross-sectional study conducted as part of the "Beijing Eye Study". The study was population-based and longitudinally designed. In 2001, a cohort of individuals aged 40 years and above from five urban communities in Haidian District and three rural communities in Daxing District, Beijing, were surveyed...
July 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/37344582/automatic-retinoblastoma-screening-and-surveillance-using-deep-learning
#28
JOURNAL ARTICLE
Ruiheng Zhang, Li Dong, Ruyue Li, Kai Zhang, Yitong Li, Hongshu Zhao, Jitong Shi, Xin Ge, Xiaolin Xu, Libin Jiang, Xuhan Shi, Chuan Zhang, Wenda Zhou, Liangyuan Xu, Haotian Wu, Heyan Li, Chuyao Yu, Jing Li, Jianmin Ma, Wenbin Wei
BACKGROUND: Retinoblastoma is the most common intraocular malignancy in childhood. With the advanced management strategy, the globe salvage and overall survival have significantly improved, which proposes subsequent challenges regarding long-term surveillance and offspring screening. This study aimed to apply a deep learning algorithm to reduce the burden of follow-up and offspring screening. METHODS: This cohort study includes retinoblastoma patients who visited Beijing Tongren Hospital from March 2018 to January 2022 for deep learning algorism development...
June 21, 2023: British Journal of Cancer
https://read.qxmd.com/read/37305940/-the-clinical-characteristics-of-parkinson-s-disease-patients-with-concomitant-periodic-limb-movements-in-sleep
#29
JOURNAL ARTICLE
H Q Zhao, J Ma, N Zhang, T Feng
The current study aimed to investigate the clinical characteristics of Parkinson's disease (PD) patients with concomitant periodic limb movements in sleep (PLMS). The clinical data of 36 PD patients who underwent polysomnography (PSG) in Beijing Tiantan Hospital from October 2018 to July 2022 were collected. Unified Parkinson's Disease Rating Scale 3.0 and Hoehn & Yahr (H-Y) stage were used to evaluate the disease severity. Patients were divided into two groups: the PLMS+group periodic limb movements in sleep index [(PLMSI)≥15 times/h] and the PLMS-group (PLMSI<15 times/h), using the PLMSI 15 times/h as the cut-off value...
June 20, 2023: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/37269495/clinical-analysis-of-2790-children-with-retinoblastoma-a-single-center-experience-in-china
#30
JOURNAL ARTICLE
Yi Zhang, Yi-Zhuo Wang, Ji-Tong Shi, Jian-Min Ma, Bin Li, Wei-Ling Zhang, Hua-Li Gu, Yan Zhou, Yan-Yan Mei, Song Li, Ting-Ting Liu, Li-Bin Jiang, Hong-Shu Zhao, Xin Ge, Hui-Min Hu, Tian Zhi, Dong-Sheng Huang
BACKGROUND: In this study, we aimed to analyze the clinical characteristics and prognosis of children with retinoblastoma (RB) in a single center in China with a large sample collection spanning 17 years. METHODS: The clinical data of 2790 children with RB treated in Beijing Tongren Hospital from 2005 to 2021 were collected, and a retrospective analysis was conducted. RESULTS: The median age of the participants was 28.3 months. There were 3624 affected eyes, 12...
June 3, 2023: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/37234156/low-dose-post-transplant-cyclophosphamide-with-g-csf-atg-based-haploidentical-protocol-provides-favorable-outcomes-for-saa-patients
#31
JOURNAL ARTICLE
Xiaodi Ma, Zhengli Xu, Tingting Han, Yuanyuan Zhang, Wei Han, Haixia Fu, Xiaohui Zhang, Fan Lin, Xiaojun Huang, Lanping Xu
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT), as one of the life-saving treatments for severe aplastic anemia (SAA), is widely used because of its great donor availability. Over decades, granulocyte colony-stimulating factor (G-CSF)/antithymocyte globulin (ATG)-based protocol (the so-called Beijing Protocol) has achieved favorable engraftment and survival outcomes. In this study, we modified the conventional Beijing Protocol: the full-dose Cyclophosphamide (Cy) (200 mg/kg in total) was divided into 42...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37176786/clinical-analysis-of-repeat-penetrating-keratoplasty-in-children
#32
JOURNAL ARTICLE
Yajie Sun, Qi Lin, Peng Song, Xu Li, Zhiqiang Pan
(1) Background: To analyze the indications, graft survival, and graft failure-related risk factors of repeat penetrating keratoplasty (RPK) in children. (2) Methods: In this case series, children younger than 12 years who received RPK at Beijing Tongren Hospital were reviewed. The indications for RPK, postoperative complications, and graft survival were analyzed. The analysis of the potential variables associated with graft survival was performed using Cox proportional hazards regression. (3) Results: A total of 30 RPK eyes of 29 children were included in this study...
May 8, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37155126/electroencephalographic-slowdowns-during-sleep%C3%A2-are-associated-with-cognitive-impairment-in-patients-who-have-obstructive-sleep-apnea%C3%A2-but-no-dementia
#33
JOURNAL ARTICLE
Yibing Qin, Chao Sun, Hairong Sun, Mengfan Li, Bing Leng, Ran Yao, Zhenguang Li, Jinbiao Zhang
OBJECTIVES: To research the relationship between quantitative electroencephalogram (qEEG) and impaired cognitive function patients who have obstructive sleep apnea (OSA) but no dementia. METHODS: Subjects who complained of snoring between March 2020 and April 2021 in the Sleep Medicine Center of Weihai Municipal Hospital were included. All subjects underwent overnight in-laboratory polysomnography (PSG) and were assessed using a neuropsychological scale. Standard fast fourier transform (FFT) was used to obtain the electroencephalogram (EEG) power spectral density curve, and to calculate the delta, theta, alpha, and beta relative power and the ratio between slow and fast frequencies...
May 8, 2023: Sleep & Breathing
https://read.qxmd.com/read/37151009/-efficacy-and-safety-of-intravitreal-dexamethasone-implant-in-diabetic-macular-edema-patients-with-and-without-prior-vitrectomy-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
L Y Li, J Li, Y Li, W Zhang, D Y Wang, W L Wang, B Y Liang, W Gu
Objective: To evaluate the effectiveness and safety of intravitreal dexamethasone implant (IDI) in diabetic macular edema (DME) patients with and without prior vitrectomy. Methods: A retrospective cohort study was conducted on DME patients who received IDI treatment at the Aier Eye Hospital, Beijing from March 2018 to August 2020. Patients were divided into two groups according to whether they had undergone vitrectomy or not. Clinical and follow-up data, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), occurrence of ocular and systemic complications, and time to DME recurrence and retreatment, were collected before and after IDI injection at 15 days, 1, 2, 3, and 6 months...
May 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/37151006/-characteristics-of-primary-ocular-symptoms-in-children-with-optic-pathway-glioma-at-different-ages
#35
JOURNAL ARTICLE
Gulina Mijiti, W Shi, L Li, J F Yu, M Ge, H G Yan, C X Peng
Objective: To investigate the characteristics of initial ocular symptoms in children with optic pathway glioma (OPG) at different age stages. Methods: A retrospective case series study was conducted. Clinical data of 16 children with OPG who were diagnosed and treated in the Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University from April 2017 to July 2021 were collected. The initial ocular symptoms, clinical manifestations of the eyes and nervous system, imaging and histopathological features were analyzed, and the differences in initial ocular symptoms between infants and young children aged≤36 months and older children aged>36 months were compared...
May 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/37148291/comparative-analysis-of-ultrasonic-elastosonography-and-contrast-enhanced-ultrasonography-in-the-diagnosis-of-benign-and-malignant-intraocular-tumors
#36
JOURNAL ARTICLE
Wei Chen, Wenli Yang, Dongjun Li, Ziyang Wang, Qi Zhao, Yifeng Li, Rui Cui, Lin Shen
PURPOSE: To compare the diagnostic value of ultrasonic elastosonography (UE) and contrast-enhanced ultrasonography (CEUS) for benign and malignant intraocular tumors. METHODS: This retrospective study enrolled patients with intraocular tumors at Beijing Tongren Hospital, Capital Medical University (August 2016 to January 2020). The strain rate ratio (strain rate of tumor tissue divided by strain rate of surrounding normal tissue) was measured by UE. CEUS was performed using SonoVue® contrast agent...
May 6, 2023: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/37101204/isolated-optic-neuritis-with-positive-glial-fibrillary-acidic-protein-antibody
#37
JOURNAL ARTICLE
Nan Jia, Jiawei Wang, Yuhong He, Zhong Li, Chuntao Lai
BACKGROUND AND OBJECTIVES: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) has been reported as a spectrum of autoimmune, inflammatory central nervous system disorders. Linear perivascular radial gadolinium enhancement patterns on brain magnetic resonance imaging (MRI) are a hallmark of these disorders. GFAP-A is associated with cerebrospinal fluid (CSF) GFAP antibody (GFAP-Ab), while the association with serum GFAP-Ab is less clear. This study aimed to observe the clinical characteristic and MRI changes of GFAP-Ab-positive optic neuritis (ON)...
April 26, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37085809/clinical-outcomes-of-implantation-of-posterior-chamber-phakic-intraocular-lens-for-pathologic-and-non-pathologic-myopia
#38
JOURNAL ARTICLE
Lin Caixia, Bai Yawen, Fang Yuxin, Li Xiaoxia, Wang Yuhan, Yang Ke, Qiao Liya
BACKGROUND: To compare the clinical outcomes of posterior chamber phakic intraocular lens (pIOL) implantation for non-pathological myopia and pathological myopia. METHODS: This retrospective case series study which were conducted in Beijing Tongren Eye Center between July 2017 and Oct 2021 comprised 192 eyes of 100 consecutive patients undergoing pIOL implantation. Eyes were divided into two groups based on having pathological myopia or not. Predictability, efficacy, safety, and adverse events were compared at 6 months after pIOL implantation...
April 21, 2023: BMC Ophthalmology
https://read.qxmd.com/read/37059320/detection-of-keratoconus-with-a-new-corvis-biomechanical-index-optimized-for-chinese-population-ccbi
#39
JOURNAL ARTICLE
Riccardo Vinciguerra, Renato Ambrosio, Yan Wang, Fengju Zhang, Xingtao Zhou, Ji Bai, Keming Yu, Shihao Chen, Xuejun Fang, Paolo Vinciguerra
PURPOSE: The aim of this study was to introduce an optimized version of the Corvis Biomechanical Index for Chinese population (cCBI). DESIGN: Retrospective, multicenter clinical validity-enhancement study. METHODS: Patients were included from seven clinics (Beijing, Shenyang, Guangzhou, Shanghai, Wenzhou, Chongqing and Tianjin). Logistic regression was employed to optimize the values of the constants of the CBI, based on Database 1 as the development dataset (six out of 7 clinics), to create a new version of the index named cCBI...
April 12, 2023: American Journal of Ophthalmology
https://read.qxmd.com/read/37012591/-analysis-of-clinical-manifestations-and-imaging-characteristics-of-in-vivo-confocal-microscopy-for-nocardia-keratitis
#40
JOURNAL ARTICLE
X Y Guo, Z Q Wang, K X Chen, Y Zhang, Z Y Wei, Q F Liang
Objective: To analyze the clinical manifestations and imaging characteristics of in vivo confocal microscopy (IVCM) for Nocardia keratitis. Methods: It was a retrospective case series study. Medical records of 16 consecutive patients (16 eyes) with Nocardia keratitis were collected from the Department of Ophthalmology at Beijing Tongren Hospital, Capital Medical University between 2018 and 2022. The group consisted of 11 males and 5 females. The inclusion criteria for the study were the presence of typical clinical manifestations of Nocardia keratitis and at least one positive pathogenic test (corneal scraping or microbial culture) indicating Nocardia infection...
April 11, 2023: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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