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The beijing eye study

Allison M McKendrick, Jonathan Denniss, Ya Xing Wang, Jost B Jonas, Andrew Turpin
PURPOSE: Interindividual variance in optic nerve head (ONH) position, axial length, and location of the temporal raphe suggest that customizing mapping between visual field locations and ONH sectors for individuals may be clinically useful. Herein we quantify the proportion of the population predicted to have structure-function mappings that markedly deviate from "average," and thus would benefit from customized mapping. DESIGN: Database study and case report. PARTICIPANTS: Population database of 2836 eyes from the Beijing Eye Study and a single case report of an individual with primary open-angle glaucoma...
February 10, 2017: Ophthalmology
Jing Mo, Anli Duan, Szyyann Chan, Xuefei Wang, Wenbin Wei
OBJECTIVES: To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. DESIGN: A prospective comparative study was conducted from December 2015 to March 2016. SETTING: Participants were recruited in Beijing Tongren Hospital. PARTICIPANTS: A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0...
February 3, 2017: BMJ Open
Y J Huo, L L Yang, W B Wei
Objective: To determine the diagnostic performance of confocal scanning laser ophthalmoscope (cSLO)-based retinal imaging in the epiretinal membrane (ERM) patients. Methods: Prospective case series study. Twenty-six patients (32 eyes) with ERM determined by spectral domain optical coherence tomography (SD-OCT) were recruited from June 2015 to October 2015 in the Beijing Tongren Eye Center. All subjects underwent retinal imaging using the cSLO-based Heidelberg MultiColor (Spectralis HRA-2; Heidelberg Engineering) technology and the traditional color fundus camera...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Y Z Wang, D S Huang, J T Shi, J M Ma, B Li, X L Xu, H M Hu, Y Zhou, H L Gu
Objective: To observe the treatment and prognosis of choroid invasion of retinoblastoma (RB) in children. Method: A total of 149 children who had been diagnosed with unilateral RB and received enucleation disclosing tumor invasion to choroid from January 2006 to December 2013 in Beijing Tongren Hospital were recruited in this study. Choroid involvement was classified as massive choroid invasion and focal choroid invasion. Massive choroid invasion was defined as a maximum diameter of invasive tumor focus of 3 mm or more in diameter that might reach the scleral tissue...
November 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
J J Huang, B Li, Q F Liang, X L Xu, F Gao, Z B Zhang
Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. All the pathology diagnosis results were divided into two categories which were benign and malignant tumors, according to Shields histopathological classification methods and the pathology diagnosis results in our department...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
David Fleischman, Amanda K Bicket, Sandra S Stinnett, John P Berdahl, Jost B Jonas, Ning Li Wang, Michael P Fautsch, R Rand Allingham
Purpose: To evaluate a frequently used regression model and a new, modified regression model to estimate cerebrospinal fluid pressure (CSFP). Methods: Datasets from the Beijing iCOP study from Tongren Hospital, Beijing, China, and the Mayo Clinic, Rochester, Minnesota, were tested in this retrospective, case-control study. An often-used regression model derived from the Beijing iCOP dataset, but without radiographic data, was used to predict CSFP by using demographic and physiologic data...
October 1, 2016: Investigative Ophthalmology & Visual Science
H Li, X H Wang, F Fang, C H Ding, J L Lyu, C H Chen, T L Han, Y Wu, W H Zhang, J W Li, H M Wang, X Y Yang, S Zhang, J Deng, S Gong, X Sun, L F Dai
OBJECTIVE: To study the clinical and electroencephalographic (EEG) characteristics of anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis) in children. METHOD: Retrospective analysis was performed on the clinical and EEG data of 105 patients with anti-NMDAR encephalitis treated in Beijing Children's Hospital (August 2011-March 2015). Of the 105 patients, 38 were male and 67 were female.The age of onset was from 6 months and 26 days to 15 years and 8 months (average (8±4)years)...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Liu Yang, Yuanzhen Qu, Wen Lu, Fengjun Liu
BACKGROUND The aim of this study was to compare the differences in macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) in child and adult patients with primary craniopharyngioma by Fourier-domain optical coherence tomography (FD-OCT) and to evaluate their significance in the diagnosis of primary craniopharyngioma. MATERIAL AND METHODS Ninety-six participants were divided into 3 groups: 32 in the child craniopharyngioma group (CCG) and 32 in the adult craniopharyngioma group (ACG) who were treated in Beijing Tiantan Hospital between November 2013 and October 2014, and 32 in the normal group (NG)...
July 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Xue Li, Shaoya Zhang, Qingfeng Liang, Mei Wang, Ailian Hu, Xiuyuan Li, Benshan Yang, Mingxin Zhang, Ningli Wang, Xinxin Lu
To study the molecular characteristics of Chlamydia trachomatis, the major outer membrane protein gene (ompA) of C. trachomatis from primary school students with trachoma residing in the Qinghai Tibetan area was sequenced and compared with the same serotype in GenBank. In Jianshetang Primary School and Galeng Central Primary School in the Galeng Tibetan Township of Qinghai Haidong Sala Autonomous County, scraped samples were collected from the upper tarsal conjunctiva and lower conjunctival sac of both eyes of 45 students with trachoma, stored at 4°C, and transported to Beijing Tongren Hospital by air within 24 h...
June 2016: Science China. Life Sciences
Jinqiong Zhou, Wenbin Wei, Qisheng You, Ying Tu
OBJECTIVE: To investigate the characteristics of bilateral rhegmatogenous retinal detachment (RRD) in a hospital-based population. METHODS: Six hundred and three patients diagnosed with bilateral RRD in the Beijing Tongren Hospital between January 2000 and January 2014 were identified and included into the study. The clinical features including the age when retinal detachment occurrence, time interval between the occurrence of the bilateral RRDs, predisposing characteristics such as myopia, trauma, et al...
May 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Jost B Jonas, Liang Xu, Ya Xing Wang, Hong Sheng Bi, Jian Feng Wu, Wen Jun Jiang, Vinay Nangia, Ajit Sinha, Dan Zhu, Yong Tao, Yin Guo, Qi Sheng You, Li Juan Wu, Li Xin Tao, Xiu Hua Guo, Kyoko Ohno-Matsui, Songhomitra Panda-Jonas
PURPOSE: Since high myopia in the younger generation may differ etiologically from high myopia in older generations, we examined whether education-related parameters differ between high myopia in today´s school children and high pathological myopia in today´s elderly generation. METHODS: The investigation included the adult populations of the population-based Beijing Eye Study (BES) (3468 adults;mean age:64.6±9.8years;range:50-93years) and Central India Eye and Medical Study (CIEMS) (4711 adults;age:49...
2016: PloS One
Jost B Jonas, Hong Sheng Bi, Jian Feng Wu, Liang Xu, Ya Xing Wang, Wen Bin Wei, Vinay Nangia, Ajit Sinha, Yin Guo, Qi Sheng You, Kyoko Ohno-Matsui, Songhomitra Panda-Jonas
PURPOSE: To assess whether anterior corneal curvature radius (CCR) is associated with the increased prevalence of myopia in Asia. METHODS: The investigation included the adult populations of the Central India Eye and Medical Study (CIEMS; 4711 adults) and Beijing Eye Study (BES; 3468 adults) and the children and teenager populations of the Shandong Children Eye Study (6026 children; age: 9.7 ± 3.3 years; range: 4-18 years) and Beijing Pediatric Eye Study (681 children; age: 7...
October 2016: Cornea
Jost B Jonas, Liang Xu, Wen Bin Wei, Zhe Pan, Hua Yang, Leonard Holbach, Songhomitra Panda-Jonas, Ya Xing Wang
PURPOSE: To examine the relationships between axial length and foveal and peripheral retinal thickness. METHODS: Using optical coherence tomography, foveal retinal thickness was measured in participants of the population-based Beijing Eye Study without optic nerve or macula diseases. Inner and outer nuclear layer thickness as surrogate for retinal thickness was assessed in the fundus periphery in human globes enucleated due to malignant uveal melanoma or painful glaucoma...
April 2016: Investigative Ophthalmology & Visual Science
Jing Li, Yiquan Yang, Diya Yang, Xiangxiang Liu, Yunxiao Sun, Shifei Wei, Ningli Wang
OBJECTIVE: To study the normal values of the retinal oxygen saturation in Rhesus monkeys and to evaluated repeatability and reproducibility of retinal oxygen saturation measurements. METHODS: Eighteen adult Rhesus macaque monkeys were included in this experimental study. An Oxymap T1 retinal oximeter (Oxymap, Reykjavik, Iceland) was used to perform oximetry on all subjects. Global arterial (SaO2) and venous oxygen saturation (SvO2), arteriovenous difference in SO2 were measured...
2016: PloS One
Yang Li, Qi Sheng You, Wen Bin Wei, Jie Xu, Chang Xi Chen, Ya Xing Wang, Liang Xu, Jost B Jonas
PURPOSE: To determine the prevalence and associations of central serous chorioretinopathy (CSC) in elderly Chinese. METHODS: The population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals (age: 64.6 ± 9.8 years; range: 50-93 years), who underwent enhanced depth imaging of spectral-domain optical coherence tomography (SD-OCT). CSC was defined as serous detachment of the retina in the macular region without signs of haemorrhages or signs of polypoidal choroidal vasculopathy, exudative age-related macular degeneration or other retinal vascular disorders, both on fundus photographs and on optical coherence tomography (OCT) images...
June 2016: Acta Ophthalmologica
Ruowu Hou, Zheng Zhang, Diya Yang, Huaizhou Wang, Weiwei Chen, Zhen Li, Jinghong Sang, Sumeng Liu, Yiwen Cao, Xiaobin Xie, Ruojing Ren, Yazhuo Zhang, Bernhard A Sabel, Ningli Wang
To determine the interdependence of intracranial pressure (ICP) and intraocular pressure (IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure (LCP), optic nerve subarachnoid space pressure (ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP (via shunting cerebrospinal fluid (CSF) from the ventricle) were recorded...
May 2016: Science China. Life Sciences
Qingchen Li, Feifei Dai, Liping Zhu, Jiawei Wang, Yun Jing
OBJECTIVE: To investigate the clinical features of ocular syndromes in patients with neurobrucellosis. METHOD: This is a retrospective series case study. The clinical data of 5 patients with neurobrucellosis, who were treated in Department of Neurology, Beijing Tongren Hospital, Captical Medical Uinversity, from May 2009 to January 2015, were collected. Their epidemiological information, clinical manifestation, laboratory and radiologic examination, therapy and prognosis were analyzed...
December 2015: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Tong Wu, Lei Sun, Ying Wu, Rong Xiang, Yuwei Li, Weining Rong, Fengyuan Sun, Ningli Wang
The present study aimed to assess the expression of legumain in uveal melanoma (UM) cell lines and primary UM specimens, and to determine the possible association between legumain expression and clinical as well as pathological characteristics to reveal its impact on the prognosis of patients with UM. Records of primary UM cases treated at Beijing Tongren Hospital and Tianjin Eye Hospital between 1996 and 2005 were retrieved for analysis and a total of 82 patients with uveal melanoma were included in the study...
March 2016: Molecular Medicine Reports
Jost B Jonas, Ya Xing Wang, Qi Zhang, Yuan Yuan Fan, Liang Xu, Wen Bin Wei, Rahul A Jonas
PURPOSE: The parapapillary gamma zone has been defined as the parapapillary region without Bruch's membrane. We examined which morphologic parameters are associated with the presence and size of the parapapillary gamma zone. METHODS: Using fundus photographs and spectral-domain optical coherence tomographic images of the optic nerve head in the population-based Beijing Eye Study, we determined parapapillary gamma zone width, macular Bruch's membrane length, optic disc-fovea distance, the angle of horizontal optic disc rotation, the angle of vertical optic disc rotation, and the ratio of the vertical-to-horizontal disc diameter...
February 2016: Investigative Ophthalmology & Visual Science
Xiufen Yang, Yu Deng, Hong Gu, Xuetao Ren, Apiradee Lim, Torkel Snellingen, Xipu Liu, Ningli Wang, Jeong Won Pak, Ningpu Liu, Ronald P Danis
AIMS: To describe the relationship of retinal arteriolar and venular calibre with diabetic retinopathy (DR) and related risk factors, including glucose levels and other biomarkers in a Chinese population with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study. Patients with T2DM were recruited from a local community in urban Beijing. Seven fields 30° colour fundus photographs were taken and examined for the presence and severity of DR using a standardised grading system...
October 2016: British Journal of Ophthalmology
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