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The beijing eye study

Yin Guo, Li Juan Liu, Ping Tang, Yi Feng, Yan Yun Lv, Min Wu, Liang Xu, Jost B Jonas
Purpose: To assess the development and enlargement of the parapapillary gamma zone in school children. Methods: This school-based prospective longitudinal study included Chinese children attending grade 1 in 2011 and returning for yearly follow-up examinations until 2016. These examinations consisted of a comprehensive ocular examination with biometry and color fundus photographs. The parents underwent a standardized interview. The parapapillary gamma zone was defined as the area with visible sclera at the temporal optic disc margin, and the optic disc itself was measured on fundus photographs...
March 1, 2018: Investigative Ophthalmology & Visual Science
Yan Ni Yan, Ya Xing Wang, Yan Yang, Liang Xu, Jie Xu, Qian Wang, Jing Yan Yang, Xuan Yang, Wen Jia Zhou, Kyoko Ohno-Matsui, Wen Bin Wei, Jost B Jonas
PURPOSE: To investigate the progression pattern of myopic maculopathy and associated factors in a population-based study. DESIGN: Population-based longitudinal study. PARTICIPANTS: The Beijing Eye Study including 4439 participants in 2001 was repeated in 2011, with 2695 individuals (66.4%) being re-examined in 2011. METHODS: The study participants underwent detailed ophthalmic and general examinations. Using fundus photographs obtained in 2001 and 2011, we assessed the progression of myopic maculopathy in highly myopic eyes with a refractive error ≥-6 diopters in 2001...
March 27, 2018: Ophthalmology
Yun-Yun Li, Xiu-Fen Yang, Hong Gu, Torkel Snellingen, Xi-Pu Liu, Ning-Pu Liu
AIM: To investigate the relationship between insulin resistance (IR)/β-cell dysfunction and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes mellitus (T2DM), and to explore further whether there were differences in the relationship among diabetic patients with higher and lower body mass index (BMI). METHODS: Cross-sectional study. A total of 1466 subjects with T2DM were recruited in a local Desheng Community of urban Beijing from November 2009 to June 2012 for the cohort of Beijing Desheng Diabetic Eye Study...
2018: International Journal of Ophthalmology
Yin Guo, Li Juan Liu, Ping Tang, Yi Feng, Min Wu, Yan Yun Lv, Liang Xu, Jost B Jonas
PURPOSE: To assess changes in the optic disc-fovea distance (DFD) with progressing myopia in school children. METHODS: The school-based, prospective, longitudinal study included grade-1 children in 2011 who were yearly re-examined until 2016. We measured DFD, optic disc diameters and width of parapapillary gamma zone (parapapillary region without Bruch's membrane (BM)) on fundus photographs. RESULTS: Of 382 grade-1 children examined in 2011, 294 (77...
March 25, 2018: Acta Ophthalmologica
Jost B Jonas, Wen Bin Wei, Li Ping Zhu, Liang Xu, Ya Xing Wang
To examine associations between cognitive function and ophthalmological parameters, the population-based Beijing Eye Study examined ophthalmologically and physically 3127 individuals (mean age: 64.2 ± 9.8 years). Using the mini-mental state examination, cognitive function was assessed as cognitive function score (CFS). Mean CFS was 26.3 ± 3.7 (median: 27; range: 2-30). Prevalence of mild (CFS: 23-19), moderate (CFS: 18-10) and severe cognitive dysfunction was 9.6% (95% confidence interval (CI): 8...
March 19, 2018: Scientific Reports
Jing Zhao, Ya Xing Wang, Qi Zhang, Wen Bin Wei, Liang Xu, Jost B Jonas
To study macular choroidal layer thickness, 3187 study participants from the population-based Beijing Eye Study underwent spectral-domain optical coherence tomography with enhanced depth imaging for thickness measurements of the macular small-vessel layer, including the choriocapillaris, medium-sized choroidal vessel layer (Sattler's layer) and large choroidal vessel layer (Haller's layer). In multivariate analysis, greater thickness of all three choroidal layers was associated (all P < 0.05) with higher prevalence of age-related macular degeneration (AMD) (except for geographic atrophy), while it was not significantly (all P > 0...
March 13, 2018: Scientific Reports
Jin Qiong Zhou, Ya Xing Wang, Liang Xu, Liang Zhao, Shuang Wang, Jie Xu, Qi Sheng You, Hua Yang, Wen Bin Wei, Jost B Jonas
PURPOSE: To examine frequency and associations of retinal hemorrhages. METHODS: The population-based Beijing Eye Study included 3,468 individuals. Monoscopic fundus photographs were examined for hemorrhages. RESULTS: Retinal hemorrhages were detected in 515 eyes (429 individuals) (prevalence: 7.6%; 95% confidence interval [CI]: 7.0-8.0 per eye; 12.7%; 95% CI: 11.7-13.7 per person). Higher prevalence of retinal hemorrhages was correlated (multivariate analysis) with higher systolic blood pressure (P < 0...
March 12, 2018: Retina
Y Zhang, Q L Chang, Y Zhou, Z J Hou, D M Li
Objective: To observe computed tomography (CT) imaging parameters of congenitally blind microphthalmia in Chinese patients and to provide clinical reference data for the Chinese population. Methods: It was a retrospective study for a consecutive case series of congenitally blind microphthalmia from July 2011 to July 2013. All of the patients were diagnosed in the Ocular Plastic Department, Tongren Eye Center, Beijing Tongren Hospital. We employed multi-section helical CT imaging with a computer-aided design system to observe and measure the imaging features in 82 Chinese patients (85 eyes)...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
D J Li, W L Yang, Z Y Wang, W Chen, Q Zhao, Y F Li, R Cui, L Shen, W B Wei
Objective: To compare the significance of contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the diagnosis of uveal melanoma. Methods: It was a retrospective case series study. Sixty-three cases (63 eyes) of uveal melanoma patients (confirmed by histopathology) who underwent CEUS and DCE-MRI examination at Beijing Tongren Hospital during January 2010 and May 2014 were collected, including 30 males and 33 females, with average age of 47 years (ranged from 27 to 69 years)...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Yifan Meng, Hongfei Lou, Yang Wang, Chengshuo Wang, Luo Zhang
OBJECTIVE: Although local specific immunoglobulin (sIgE) has been employed as a diagnostic criterion for allergic rhinitis (AR), the use of local sIgE has not been fully evaluated in the diagnosis of allergic rhinitis. The aim of this study was to evaluate the use of nasal secretion sIgE in the diagnosis of allergic rhinitis. METHODS: A total of 51 patients (27 males and 24 females, mean age = 33.3 years) with rhinitis symptoms were enrolled consecutively from the allergy-rhinology clinic of Beijing TongRen Hospital (Beijing, People's Republic of China)...
February 8, 2018: Laryngoscope
Yun-Yun Li, Xiu-Fen Yang, Hong Gu, Xi-Pu Liu, Torkel Snellingen, Ning-Pu Liu
AIM: To present the rationale, design, methodology, and the baseline data of the Beijing Desheng Diabetic Eye Study (BDDES), and to determine the prevalence of diabetic retinopathy (DR) and possible risk factors in patients with type 2 diabetes mellitus (T2DM) in an urban community of Beijing, China. METHODS: Community-based prospective cohort study of persons diagnosed with T2DM aged 30y or older. The main variables of interest are the presence and progression of DR as determined by the standardized ETDRS grading of seven fields fundus photographs...
2018: International Journal of Ophthalmology
Yang Liu, Yingnan Zhang, Jing Zhang, Jin Yu, Qingfeng Liang, Zhiqiang Pan
Compared with evident cornea donors (ECDs), deceased potential cornea donors (DPCDs) have no obvious donor identifications to reference, which causes many eligible cornea tissues to be wasted. The demographic characteristics of DPCDs might be different from those of ECDs owing to the following different features: donation consent provided by relatives and willingness to donate before death. Thus, the aim of this study is to reveal the demographic characteristics of DPCDs by comparing DPCDs and ECDs.The demographic factors of 138 donors (both DPCDs and ECDs) were collected from the Beijing Tongren Hospital Eye Bank database and analyzed...
December 2017: Medicine (Baltimore)
Y F Li, D J Li, Z Y Wang, W Chen, Q Zhao, R Cui, L Shen, W L Yang
Objective: To examine the features and values of ultrasonic diagnosis for retinal detachment in eyes with silicone oil tamponade (SOT). Methods: A prospective study. A total of 257 eyes (257 patients) were filled with silicone oil between December 1, 2015 and August 1, 2016 in the Department of Ophthalmology at a hospital in Beijing. All of the patients underwent a color Doppler ultrasound examination in the supine and sitting positions a week prior to surgery. The pre-surgery conditions were compared with the subsequent observations during the surgery to analyze the features and values of ultrasonic diagnosis for retinal detachment in eyes with SOT...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Yin Guo, Jia Li Duan, Li Juan Liu, Ying Sun, Ping Tang, Yan Yun Lv, Liang Xu, Jost B Jonas
PURPOSE: To assess prevalence and associated factors of myopia and high myopia in schoolchildren in Greater Beijing. METHODS: The school-based, cross-sectional Greater Beijing School Children Myopia study was carried out in the year 2016 in 54 schools randomly selected from 15 districts in Beijing. Non-cycloplegic auto-refractometry of the right eyes was performed. RESULTS: The study included 35,745 (99.4%) out of 35,968 eligible pupils with a mean age of 12...
2017: PloS One
Jialiang Zhao, Xiao Xu, Leon B Ellwein, Ning Cai, Huaijin Guan, Mingguang He, Ping Liu, Jianhua Lv, Xunlun Sheng, Peizeng Yang, Jinglin Yi, Mei Yang, Rui Zhang, Xiaohu Ding, Liping Du, Fengrong Li, Hong Lu, Wenqiang Shao, Junwei Wang, Yuansheng Yuan, Rui Zhou, Wenjuan Zhuang, Lei An
PURPOSE: To estimate the prevalence of vision impairment and blindness in 2014 among older adults in rural China with comparisons with the 2006 Nine-Province Survey. DESIGN: Population-based, cross-sectional study. METHODS: Geographical cluster sampling was used in randomly selecting residents from a rural county or semi-rural district within 9 provinces: Beijing, Jiangsu, Guangdong, Heilongjiang, Jiangxi, Hebei, Ningxia, Chongqing, and Yunnan...
January 2018: American Journal of Ophthalmology
W J Kong, C G Guo, L Y Xie, W B Wei, H W Dong, C Chen, K F Du
Objective: To explore the Cytokine of aqueous humor in AIDS patients with different eye diseases. Methods: A case-control study including 38 patients who was diagnosed as acquired immunodeficiency syndrome(AIDS) at Infectious Center and Department of Ophthalmology in Beijing You'an Hospital, Capital Medical University. And 16 cases of 38 patients were cytomegalovirus retinitis (CMVR), 14 cases were HIV-related retinal disease, and 8 cases presented as normal. A series of tests were performed including vision acuity check, intraocular pressure, fundus photography, blood cell count of CD4+ T lymphocyte and the content of cytokines in aqueous humor by Luminex 200(TM) liquid chip analyzer...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Y Zhang, Z Q Wang, X G Sun
Objective: To analyze the etiology and drug sensitivity of bacterial keratitis and their changes, and to provide evidence for treatment and drug selection of bacterial keratitis. Methods: Retrospective case series study. From January 2006 to December 2015, corneal specimens suspected of bacterial infection were collected and cultured in Beijing Tongren Eye Center. General information of patients, etiological results and drug sensitivity test results were summarized and analyzed. The Chi-square test and Spearman correlation analysis were performed using SPSS 20...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Y Liu, Y N Zhang, Y Liu, J Zhang, A P Li, Q F Liang, Z Q Pan
BACKGROUND: Lack of willingness to pledge eyes among the general population is the main cause for the shortage of cornea tissue in China. A few studies have implied that general-population adults with specific demographics showed more willingness to donate their eyes. METHODS: In this study, we analyzed the demographic characteristics of 918 voluntary donors registered in Beijing Tongren Hospital Eye Bank in the past 10 years for possible predictors that might help us to identify potential donors in Beijing and increase the donation rate...
October 2017: Transplantation Proceedings
Jing Cui, Ji-Ping Ren, Dong-Ning Chen, Zhong Xin, Ming-Xia Yuan, Jie Xu, Qi-Sheng You, Jin-Kui Yang
OBJECTIVES: The study aimed to determine the exact risk factors for diabetic retinopathy (DR) in the Chinese population using a cohort of 17  985 individuals from Beijing, China. DESIGN: Cross-sectional study. SETTING: A hospital. PARTICIPANTS: 17  985 individuals from Beijing, China. PRIMARY AND SECONDARY OUTCOME MEASURES: This was a cross-sectional study of permanent residents from the Changping area (Beijing, China) recruited from July 2010 to March 2011 and from March 2014 to February 2015 during a routine health examination at the Tongren Hospital of Beijing...
August 30, 2017: BMJ Open
Ling Xiao Zhou, Lei Shao, Liang Xu, Wen Bin Wei, Ya Xing Wang, Qi Sheng You
Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. OCT images were obtained in 103 highly myopic eyes (≤-6.00 diopters) and 227 normal eyes. The mean SFCT in highly myopic eyes was 110.6 ± 85.2 μm (range, 3 to 395 μm). The SFCT of high myopia without posterior scleral staphyloma(55 eyes) was 157...
August 29, 2017: Scientific Reports
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